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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:CAPZB-SCEL

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CAPZB-SCEL
FusionPDB ID: 13011
FusionGDB2.0 ID: 13011
HgeneTgene
Gene symbol

CAPZB

SCEL

Gene ID

832

8796

Gene namecapping actin protein of muscle Z-line subunit betasciellin
SynonymsCAPB|CAPPB|CAPZ-
Cytomap

1p36.13

13q22.3

Type of geneprotein-codingprotein-coding
DescriptionF-actin-capping protein subunit betacapZ betacapping actin protein of muscle Z-line beta subunitcapping protein (actin filament) muscle Z-line, betaepididymis secretory sperm binding proteinsciellin
Modification date2020032020200313
UniProtAcc

P47756

Main function of 5'-partner protein: FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}.		.
Ensembl transtripts involved in fusion geneENST idsENST00000264202, ENST00000375142, 
ENST00000375144, ENST00000401084, 
ENST00000433834, ENST00000264203, 
ENST00000482808, 		ENST00000469982, 
ENST00000349847, ENST00000377246, 
ENST00000535157, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score20 X 22 X 11=48407 X 7 X 5=245
# samples 298
** MAII scorelog2(29/4840*10)=-4.06088224214702
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/245*10)=-1.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: CAPZB [Title/Abstract] AND SCEL [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: CAPZB [Title/Abstract] AND SCEL [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CAPZB(19670852)-SCEL(78208514), # samples:3
Anticipated loss of major functional domain due to fusion event.CAPZB-SCEL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CAPZB-SCEL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CAPZB-SCEL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CAPZB-SCEL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSCEL

GO:0030216

keratinocyte differentiation

14632196



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:19670852/chr13:78208514)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across CAPZB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SCEL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000401084CAPZBchr119670852-ENST00000535157SCELchr1378208514+22268651341240368
ENST00000401084CAPZBchr119670852-ENST00000377246SCELchr1378208514+22308651341240368
ENST00000401084CAPZBchr119670852-ENST00000349847SCELchr1378208514+14768651341240368
ENST00000433834CAPZBchr119670852-ENST00000535157SCELchr1378208514+256412033401578412
ENST00000433834CAPZBchr119670852-ENST00000377246SCELchr1378208514+256812033401578412
ENST00000433834CAPZBchr119670852-ENST00000349847SCELchr1378208514+181412033401578412
ENST00000264202CAPZBchr119670852-ENST00000535157SCELchr1378208514+2141780491155368
ENST00000264202CAPZBchr119670852-ENST00000377246SCELchr1378208514+2145780491155368
ENST00000264202CAPZBchr119670852-ENST00000349847SCELchr1378208514+1391780491155368
ENST00000375144CAPZBchr119670852-ENST00000535157SCELchr1378208514+2090729131104363
ENST00000375144CAPZBchr119670852-ENST00000377246SCELchr1378208514+2094729131104363
ENST00000375144CAPZBchr119670852-ENST00000349847SCELchr1378208514+1340729131104363
ENST00000401084CAPZBchr119670851-ENST00000535157SCELchr1378208513+22268651341240368
ENST00000401084CAPZBchr119670851-ENST00000377246SCELchr1378208513+22308651341240368
ENST00000401084CAPZBchr119670851-ENST00000349847SCELchr1378208513+14768651341240368
ENST00000433834CAPZBchr119670851-ENST00000535157SCELchr1378208513+256412033401578412
ENST00000433834CAPZBchr119670851-ENST00000377246SCELchr1378208513+256812033401578412
ENST00000433834CAPZBchr119670851-ENST00000349847SCELchr1378208513+181412033401578412
ENST00000264202CAPZBchr119670851-ENST00000535157SCELchr1378208513+2141780491155368
ENST00000264202CAPZBchr119670851-ENST00000377246SCELchr1378208513+2145780491155368
ENST00000264202CAPZBchr119670851-ENST00000349847SCELchr1378208513+1391780491155368
ENST00000375144CAPZBchr119670851-ENST00000535157SCELchr1378208513+2090729131104363
ENST00000375144CAPZBchr119670851-ENST00000377246SCELchr1378208513+2094729131104363
ENST00000375144CAPZBchr119670851-ENST00000349847SCELchr1378208513+1340729131104363

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000401084ENST00000535157CAPZBchr119670852-SCELchr1378208514+0.0002756720.9997243
ENST00000401084ENST00000377246CAPZBchr119670852-SCELchr1378208514+0.0002786050.99972135
ENST00000401084ENST00000349847CAPZBchr119670852-SCELchr1378208514+0.0009320640.99906796
ENST00000433834ENST00000535157CAPZBchr119670852-SCELchr1378208514+0.000318650.99968135
ENST00000433834ENST00000377246CAPZBchr119670852-SCELchr1378208514+0.0003202530.9996798
ENST00000433834ENST00000349847CAPZBchr119670852-SCELchr1378208514+0.0012773950.9987226
ENST00000264202ENST00000535157CAPZBchr119670852-SCELchr1378208514+0.0002770190.999723
ENST00000264202ENST00000377246CAPZBchr119670852-SCELchr1378208514+0.0002793020.99972063
ENST00000264202ENST00000349847CAPZBchr119670852-SCELchr1378208514+0.0008941340.9991059
ENST00000375144ENST00000535157CAPZBchr119670852-SCELchr1378208514+0.000140650.99985933
ENST00000375144ENST00000377246CAPZBchr119670852-SCELchr1378208514+0.0001412960.99985874
ENST00000375144ENST00000349847CAPZBchr119670852-SCELchr1378208514+0.0003967360.99960333
ENST00000401084ENST00000535157CAPZBchr119670851-SCELchr1378208513+0.0002756720.9997243
ENST00000401084ENST00000377246CAPZBchr119670851-SCELchr1378208513+0.0002786050.99972135
ENST00000401084ENST00000349847CAPZBchr119670851-SCELchr1378208513+0.0009320640.99906796
ENST00000433834ENST00000535157CAPZBchr119670851-SCELchr1378208513+0.000318650.99968135
ENST00000433834ENST00000377246CAPZBchr119670851-SCELchr1378208513+0.0003202530.9996798
ENST00000433834ENST00000349847CAPZBchr119670851-SCELchr1378208513+0.0012773950.9987226
ENST00000264202ENST00000535157CAPZBchr119670851-SCELchr1378208513+0.0002770190.999723
ENST00000264202ENST00000377246CAPZBchr119670851-SCELchr1378208513+0.0002793020.99972063
ENST00000264202ENST00000349847CAPZBchr119670851-SCELchr1378208513+0.0008941340.9991059
ENST00000375144ENST00000535157CAPZBchr119670851-SCELchr1378208513+0.000140650.99985933
ENST00000375144ENST00000377246CAPZBchr119670851-SCELchr1378208513+0.0001412960.99985874
ENST00000375144ENST00000349847CAPZBchr119670851-SCELchr1378208513+0.0003967360.99960333

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for CAPZB-SCEL

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
CAPZBchr119670851SCELchr13782085131203287IYFGKTKDIVNGLSSNTGAKQAGPQD
CAPZBchr119670851SCELchr1378208513729238IYFGKTKDIVNGLSSNTGAKQAGPQD
CAPZBchr119670851SCELchr1378208513780243IYFGKTKDIVNGLSSNTGAKQAGPQD
CAPZBchr119670851SCELchr1378208513865243IYFGKTKDIVNGLSSNTGAKQAGPQD
CAPZBchr119670852SCELchr13782085141203287IYFGKTKDIVNGLSSNTGAKQAGPQD
CAPZBchr119670852SCELchr1378208514729238IYFGKTKDIVNGLSSNTGAKQAGPQD
CAPZBchr119670852SCELchr1378208514780243IYFGKTKDIVNGLSSNTGAKQAGPQD
CAPZBchr119670852SCELchr1378208514865243IYFGKTKDIVNGLSSNTGAKQAGPQD

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Potential FusionNeoAntigen Information of CAPZB-SCEL in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Potential FusionNeoAntigen Information of CAPZB-SCEL in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
CAPZB-SCEL_19670851_78208513.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
CAPZB-SCELchr119670851chr1378208513780DRB1-0413KDIVNGLSSNTGAKQ621
CAPZB-SCELchr119670851chr1378208513780DRB1-0415KDIVNGLSSNTGAKQ621
CAPZB-SCELchr119670851chr1378208513780DRB1-0415TKDIVNGLSSNTGAK520
CAPZB-SCELchr119670851chr1378208513780DRB1-0427KDIVNGLSSNTGAKQ621
CAPZB-SCELchr119670851chr1378208513780DRB1-0436KDIVNGLSSNTGAKQ621
CAPZB-SCELchr119670851chr1378208513780DRB1-0436TKDIVNGLSSNTGAK520
CAPZB-SCELchr119670851chr1378208513780DRB1-0437KDIVNGLSSNTGAKQ621
CAPZB-SCELchr119670851chr1378208513780DRB1-0440KDIVNGLSSNTGAKQ621
CAPZB-SCELchr119670851chr1378208513780DRB1-0440TKDIVNGLSSNTGAK520
CAPZB-SCELchr119670851chr1378208513780DRB1-0442KDIVNGLSSNTGAKQ621
CAPZB-SCELchr119670851chr1378208513780DRB1-0444KDIVNGLSSNTGAKQ621
CAPZB-SCELchr119670851chr1378208513780DRB1-0449KDIVNGLSSNTGAKQ621
CAPZB-SCELchr119670851chr1378208513780DRB1-0451KDIVNGLSSNTGAKQ621
CAPZB-SCELchr119670851chr1378208513780DRB1-0453KDIVNGLSSNTGAKQ621
CAPZB-SCELchr119670851chr1378208513780DRB1-0455KDIVNGLSSNTGAKQ621
CAPZB-SCELchr119670851chr1378208513780DRB1-0455TKDIVNGLSSNTGAK520
CAPZB-SCELchr119670851chr1378208513780DRB1-0456KDIVNGLSSNTGAKQ621
CAPZB-SCELchr119670851chr1378208513780DRB1-0456TKDIVNGLSSNTGAK520
CAPZB-SCELchr119670851chr1378208513780DRB1-0458KDIVNGLSSNTGAKQ621
CAPZB-SCELchr119670851chr1378208513780DRB1-0468KDIVNGLSSNTGAKQ621
CAPZB-SCELchr119670851chr1378208513780DRB1-0468TKDIVNGLSSNTGAK520
CAPZB-SCELchr119670851chr1378208513780DRB1-0470KDIVNGLSSNTGAKQ621
CAPZB-SCELchr119670851chr1378208513780DRB1-0470TKDIVNGLSSNTGAK520
CAPZB-SCELchr119670851chr1378208513780DRB1-0473KDIVNGLSSNTGAKQ621
CAPZB-SCELchr119670851chr1378208513780DRB1-0479KDIVNGLSSNTGAKQ621
CAPZB-SCELchr119670851chr1378208513780DRB1-0479TKDIVNGLSSNTGAK520
CAPZB-SCELchr119670851chr1378208513780DRB3-0201VNGLSSNTGAKQAGP924
CAPZB-SCELchr119670851chr1378208513780DRB3-0201IVNGLSSNTGAKQAG823
CAPZB-SCELchr119670851chr1378208513780DRB3-0201NGLSSNTGAKQAGPQ1025
CAPZB-SCELchr119670851chr1378208513780DRB3-0201DIVNGLSSNTGAKQA722
CAPZB-SCELchr119670851chr1378208513780DRB3-0202VNGLSSNTGAKQAGP924
CAPZB-SCELchr119670851chr1378208513780DRB3-0202IVNGLSSNTGAKQAG823
CAPZB-SCELchr119670851chr1378208513780DRB3-0204VNGLSSNTGAKQAGP924
CAPZB-SCELchr119670851chr1378208513780DRB3-0204IVNGLSSNTGAKQAG823
CAPZB-SCELchr119670851chr1378208513780DRB3-0204NGLSSNTGAKQAGPQ1025
CAPZB-SCELchr119670851chr1378208513780DRB3-0205VNGLSSNTGAKQAGP924
CAPZB-SCELchr119670851chr1378208513780DRB3-0205IVNGLSSNTGAKQAG823
CAPZB-SCELchr119670851chr1378208513780DRB3-0210VNGLSSNTGAKQAGP924
CAPZB-SCELchr119670851chr1378208513780DRB3-0210IVNGLSSNTGAKQAG823
CAPZB-SCELchr119670851chr1378208513780DRB3-0211VNGLSSNTGAKQAGP924
CAPZB-SCELchr119670851chr1378208513780DRB3-0211IVNGLSSNTGAKQAG823
CAPZB-SCELchr119670851chr1378208513780DRB3-0212VNGLSSNTGAKQAGP924
CAPZB-SCELchr119670851chr1378208513780DRB3-0212IVNGLSSNTGAKQAG823
CAPZB-SCELchr119670851chr1378208513780DRB3-0213VNGLSSNTGAKQAGP924
CAPZB-SCELchr119670851chr1378208513780DRB3-0214VNGLSSNTGAKQAGP924
CAPZB-SCELchr119670851chr1378208513780DRB3-0214IVNGLSSNTGAKQAG823
CAPZB-SCELchr119670851chr1378208513780DRB3-0214NGLSSNTGAKQAGPQ1025
CAPZB-SCELchr119670851chr1378208513780DRB3-0215VNGLSSNTGAKQAGP924
CAPZB-SCELchr119670851chr1378208513780DRB3-0215IVNGLSSNTGAKQAG823
CAPZB-SCELchr119670851chr1378208513780DRB3-0216VNGLSSNTGAKQAGP924
CAPZB-SCELchr119670851chr1378208513780DRB3-0217VNGLSSNTGAKQAGP924
CAPZB-SCELchr119670851chr1378208513780DRB3-0217IVNGLSSNTGAKQAG823
CAPZB-SCELchr119670851chr1378208513780DRB3-0218VNGLSSNTGAKQAGP924
CAPZB-SCELchr119670851chr1378208513780DRB3-0218IVNGLSSNTGAKQAG823
CAPZB-SCELchr119670851chr1378208513780DRB3-0219VNGLSSNTGAKQAGP924
CAPZB-SCELchr119670851chr1378208513780DRB3-0220VNGLSSNTGAKQAGP924
CAPZB-SCELchr119670851chr1378208513780DRB3-0220IVNGLSSNTGAKQAG823
CAPZB-SCELchr119670851chr1378208513780DRB3-0222VNGLSSNTGAKQAGP924
CAPZB-SCELchr119670851chr1378208513780DRB3-0223VNGLSSNTGAKQAGP924
CAPZB-SCELchr119670851chr1378208513780DRB3-0223IVNGLSSNTGAKQAG823
CAPZB-SCELchr119670851chr1378208513780DRB3-0224VNGLSSNTGAKQAGP924
CAPZB-SCELchr119670851chr1378208513780DRB3-0224IVNGLSSNTGAKQAG823
CAPZB-SCELchr119670851chr1378208513780DRB3-0224NGLSSNTGAKQAGPQ1025
CAPZB-SCELchr119670851chr1378208513780DRB3-0224DIVNGLSSNTGAKQA722
CAPZB-SCELchr119670851chr1378208513780DRB3-0225VNGLSSNTGAKQAGP924
CAPZB-SCELchr119670851chr1378208513780DRB3-0225IVNGLSSNTGAKQAG823
CAPZB-SCELchr119670851chr1378208513780DRB3-0301VNGLSSNTGAKQAGP924

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Fusion breakpoint peptide structures of CAPZB-SCEL

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of CAPZB-SCEL

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score

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Vaccine Design for the FusionNeoAntigens of CAPZB-SCEL

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
CAPZB-SCELchr119670851chr13782085131025NGLSSNTGAKQAGPQTGGGCTGAGCTCTAACACTGGAGCCAAGCAGGCAGGACCACAGGA
CAPZB-SCELchr119670851chr1378208513520TKDIVNGLSSNTGAKAAAGGATATCGTCAATGGGCTGAGCTCTAACACTGGAGCCAAGCA
CAPZB-SCELchr119670851chr1378208513621KDIVNGLSSNTGAKQGGATATCGTCAATGGGCTGAGCTCTAACACTGGAGCCAAGCAGGC
CAPZB-SCELchr119670851chr1378208513722DIVNGLSSNTGAKQATATCGTCAATGGGCTGAGCTCTAACACTGGAGCCAAGCAGGCAGG
CAPZB-SCELchr119670851chr1378208513823IVNGLSSNTGAKQAGCGTCAATGGGCTGAGCTCTAACACTGGAGCCAAGCAGGCAGGACC
CAPZB-SCELchr119670851chr1378208513924VNGLSSNTGAKQAGPCAATGGGCTGAGCTCTAACACTGGAGCCAAGCAGGCAGGACCACA

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Information of the samples that have these potential fusion neoantigens of CAPZB-SCEL

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample

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Potential target of CAR-T therapy development for CAPZB-SCEL

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to CAPZB-SCEL

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CAPZB-SCEL

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource