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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:CDC42BPA-HYOU1

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CDC42BPA-HYOU1
FusionPDB ID: 14837
FusionGDB2.0 ID: 14837
HgeneTgene
Gene symbol

CDC42BPA

HYOU1

Gene ID

8476

10525

Gene nameCDC42 binding protein kinase alphahypoxia up-regulated 1
SynonymsMRCK|MRCKA|PK428GRP-170|Grp170|HSP12A|IMD59|ORP-150|ORP150
Cytomap

1q42.13

11q23.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase MRCK alphaCDC42 binding protein kinase alpha (DMPK-like)CDC42 binding protein kinase betamyotonic dystrophy kinase-related CDC42-binding protein kinase alphamyotonic dystrophy protein kinase-like alphaser-thr protein khypoxia up-regulated protein 1150 kDa oxygen-regulated protein170 kDa glucose-regulated proteinepididymis secretory sperm binding proteinoxygen regulated protein (150kD)
Modification date2020031320200313
UniProtAcc

Q5VT25

Main function of 5'-partner protein: FUNCTION: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9418861, PubMed:9092543). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}.

Q9Y4L1

Main function of 5'-partner protein: FUNCTION: Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. {ECO:0000269|PubMed:10037731}.
Ensembl transtripts involved in fusion geneENST idsENST00000334218, ENST00000366764, 
ENST00000366765, ENST00000366766, 
ENST00000366767, ENST00000366769, 
ENST00000535525, ENST00000488131, 
ENST00000404233, ENST00000525859, 
ENST00000529972, ENST00000543287, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 12 X 9=15128 X 12 X 3=288
# samples 1511
** MAII scorelog2(15/1512*10)=-3.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/288*10)=-1.38856528791765
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: CDC42BPA [Title/Abstract] AND HYOU1 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: CDC42BPA [Title/Abstract] AND HYOU1 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CDC42BPA(227400837)-HYOU1(118920549), # samples:2
Anticipated loss of major functional domain due to fusion event.CDC42BPA-HYOU1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC42BPA-HYOU1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC42BPA-HYOU1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC42BPA-HYOU1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDC42BPA

GO:0006468

protein phosphorylation

9092543

HgeneCDC42BPA

GO:0031532

actin cytoskeleton reorganization

9418861

TgeneHYOU1

GO:0006888

ER to Golgi vesicle-mediated transport

10837345

TgeneHYOU1

GO:0071456

cellular response to hypoxia

10837345

TgeneHYOU1

GO:1903298

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

10037731



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:227400837/chr11:118920549)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across CDC42BPA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HYOU1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000366767CDC42BPAchr1227400837-ENST00000404233HYOU1chr11118920549-309435401688562
ENST00000366767CDC42BPAchr1227400837-ENST00000529972HYOU1chr11118920549-290535401502500
ENST00000366767CDC42BPAchr1227400837-ENST00000525859HYOU1chr11118920549-178535401502500
ENST00000366767CDC42BPAchr1227400837-ENST00000543287HYOU1chr11118920549-11203540629209
ENST00000366769CDC42BPAchr1227400837-ENST00000404233HYOU1chr11118920549-4386164612922980562
ENST00000366769CDC42BPAchr1227400837-ENST00000529972HYOU1chr11118920549-4197164612922794500
ENST00000366769CDC42BPAchr1227400837-ENST00000525859HYOU1chr11118920549-3077164612922794500
ENST00000366769CDC42BPAchr1227400837-ENST00000543287HYOU1chr11118920549-2412164624001405331
ENST00000366764CDC42BPAchr1227400837-ENST00000404233HYOU1chr11118920549-403712979432631562
ENST00000366764CDC42BPAchr1227400837-ENST00000529972HYOU1chr11118920549-384812979432445500
ENST00000366764CDC42BPAchr1227400837-ENST00000525859HYOU1chr11118920549-272812979432445500
ENST00000366764CDC42BPAchr1227400837-ENST00000543287HYOU1chr11118920549-2063129720511056331
ENST00000334218CDC42BPAchr1227400837-ENST00000404233HYOU1chr11118920549-403712979432631562
ENST00000334218CDC42BPAchr1227400837-ENST00000529972HYOU1chr11118920549-384812979432445500
ENST00000334218CDC42BPAchr1227400837-ENST00000525859HYOU1chr11118920549-272812979432445500
ENST00000334218CDC42BPAchr1227400837-ENST00000543287HYOU1chr11118920549-2063129720511056331
ENST00000366766CDC42BPAchr1227400837-ENST00000404233HYOU1chr11118920549-403712979432631562
ENST00000366766CDC42BPAchr1227400837-ENST00000529972HYOU1chr11118920549-384812979432445500
ENST00000366766CDC42BPAchr1227400837-ENST00000525859HYOU1chr11118920549-272812979432445500
ENST00000366766CDC42BPAchr1227400837-ENST00000543287HYOU1chr11118920549-2063129720511056331
ENST00000535525CDC42BPAchr1227400837-ENST00000404233HYOU1chr11118920549-3121381271715562
ENST00000535525CDC42BPAchr1227400837-ENST00000529972HYOU1chr11118920549-2932381271529500
ENST00000535525CDC42BPAchr1227400837-ENST00000525859HYOU1chr11118920549-1812381271529500
ENST00000535525CDC42BPAchr1227400837-ENST00000543287HYOU1chr11118920549-114738127656209
ENST00000366765CDC42BPAchr1227400837-ENST00000404233HYOU1chr11118920549-36268865322220562
ENST00000366765CDC42BPAchr1227400837-ENST00000529972HYOU1chr11118920549-34378865322034500
ENST00000366765CDC42BPAchr1227400837-ENST00000525859HYOU1chr11118920549-23178865322034500
ENST00000366765CDC42BPAchr1227400837-ENST00000543287HYOU1chr11118920549-16528861640645331

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366767ENST00000404233CDC42BPAchr1227400837-HYOU1chr11118920549-0.0030063280.99699366
ENST00000366767ENST00000529972CDC42BPAchr1227400837-HYOU1chr11118920549-0.0022495280.99775046
ENST00000366767ENST00000525859CDC42BPAchr1227400837-HYOU1chr11118920549-0.0034039860.99659604
ENST00000366767ENST00000543287CDC42BPAchr1227400837-HYOU1chr11118920549-0.0084678940.99153215
ENST00000366769ENST00000404233CDC42BPAchr1227400837-HYOU1chr11118920549-0.0025174840.9974826
ENST00000366769ENST00000529972CDC42BPAchr1227400837-HYOU1chr11118920549-0.0019762770.99802375
ENST00000366769ENST00000525859CDC42BPAchr1227400837-HYOU1chr11118920549-0.0021067450.9978933
ENST00000366769ENST00000543287CDC42BPAchr1227400837-HYOU1chr11118920549-0.0046957040.99530435
ENST00000366764ENST00000404233CDC42BPAchr1227400837-HYOU1chr11118920549-0.0021528260.9978472
ENST00000366764ENST00000529972CDC42BPAchr1227400837-HYOU1chr11118920549-0.0016724170.99832755
ENST00000366764ENST00000525859CDC42BPAchr1227400837-HYOU1chr11118920549-0.0016774560.99832255
ENST00000366764ENST00000543287CDC42BPAchr1227400837-HYOU1chr11118920549-0.0038803510.9961196
ENST00000334218ENST00000404233CDC42BPAchr1227400837-HYOU1chr11118920549-0.0021528260.9978472
ENST00000334218ENST00000529972CDC42BPAchr1227400837-HYOU1chr11118920549-0.0016724170.99832755
ENST00000334218ENST00000525859CDC42BPAchr1227400837-HYOU1chr11118920549-0.0016774560.99832255
ENST00000334218ENST00000543287CDC42BPAchr1227400837-HYOU1chr11118920549-0.0038803510.9961196
ENST00000366766ENST00000404233CDC42BPAchr1227400837-HYOU1chr11118920549-0.0021528260.9978472
ENST00000366766ENST00000529972CDC42BPAchr1227400837-HYOU1chr11118920549-0.0016724170.99832755
ENST00000366766ENST00000525859CDC42BPAchr1227400837-HYOU1chr11118920549-0.0016774560.99832255
ENST00000366766ENST00000543287CDC42BPAchr1227400837-HYOU1chr11118920549-0.0038803510.9961196
ENST00000535525ENST00000404233CDC42BPAchr1227400837-HYOU1chr11118920549-0.0031723150.99682766
ENST00000535525ENST00000529972CDC42BPAchr1227400837-HYOU1chr11118920549-0.0023614690.9976386
ENST00000535525ENST00000525859CDC42BPAchr1227400837-HYOU1chr11118920549-0.0037376460.9962624
ENST00000535525ENST00000543287CDC42BPAchr1227400837-HYOU1chr11118920549-0.0091924040.9908076
ENST00000366765ENST00000404233CDC42BPAchr1227400837-HYOU1chr11118920549-0.0019986330.9980014
ENST00000366765ENST00000529972CDC42BPAchr1227400837-HYOU1chr11118920549-0.0014584390.9985416
ENST00000366765ENST00000525859CDC42BPAchr1227400837-HYOU1chr11118920549-0.0014414320.9985586
ENST00000366765ENST00000543287CDC42BPAchr1227400837-HYOU1chr11118920549-0.0037181780.9962818

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for CDC42BPA-HYOU1

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
CDC42BPAchr1227400837HYOU1chr111189205491297118KILNKWEMLKRAEVESVFETLVEDSA
CDC42BPAchr1227400837HYOU1chr111189205491646118KILNKWEMLKRAEVESVFETLVEDSA
CDC42BPAchr1227400837HYOU1chr11118920549354118KILNKWEMLKRAEVESVFETLVEDSA
CDC42BPAchr1227400837HYOU1chr11118920549381118KILNKWEMLKRAEVESVFETLVEDSA
CDC42BPAchr1227400837HYOU1chr11118920549886118KILNKWEMLKRAEVESVFETLVEDSA

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Potential FusionNeoAntigen Information of CDC42BPA-HYOU1 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
CDC42BPA-HYOU1_227400837_118920549.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B08:09EMLKRAEV0.99970.9557614
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B08:01EMLKRAEV0.99950.9198614
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B27:04KRAEVESVF0.99940.8278918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B27:02KRAEVESVF0.99930.611918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B27:05KRAEVESVF0.99920.813918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B27:07KRAEVESVF0.99640.5595918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B45:01AEVESVFET0.99530.9231120
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B50:02AEVESVFET0.98740.71581120
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B41:02WEMLKRAEV0.97420.6368514
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B41:01WEMLKRAEV0.90770.9918514
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B38:02KRAEVESVF0.8220.9017918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B38:01KRAEVESVF0.78160.8983918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B35:04EVESVFETL0.70730.96841221
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B35:02EVESVFETL0.70730.96841221
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B15:03KRAEVESVF0.5810.8671918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B15:18KRAEVESVF0.51440.8363918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B41:01AEVESVFET0.39990.92231120
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B15:10KRAEVESVF0.28110.6784918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B50:01AEVESVFET0.1710.79381120
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B44:03AEVESVFETL0.9980.98791121
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B13:01AEVESVFETL0.99380.9661121
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B47:01AEVESVFETL0.99290.69831121
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B45:01AEVESVFETL0.97510.90761121
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B39:13AEVESVFETL0.88740.96491121
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B41:01AEVESVFETL0.77390.90611121
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B27:02MLKRAEVESVF0.99320.5703718
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B15:18MLKRAEVESVF0.9570.7006718
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B40:06WEMLKRAEV0.99960.8715514
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B27:14KRAEVESVF0.99910.7246918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-C07:95KRAEVESVF0.99790.617918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-C07:05KRAEVESVF0.99430.9501918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-C07:27KRAEVESVF0.98930.9312918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-C07:29KRAEVESVF0.98680.8853918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B40:06AEVESVFET0.98590.75551120
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B27:03KRAEVESVF0.98550.8243918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-C07:46KRAEVESVF0.97340.8706918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-C07:13KRAEVESVF0.96970.8765918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-C07:19KRAEVESVF0.96150.7506918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-C07:67KRAEVESVF0.93310.9287918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-C07:80KRAEVESVF0.93310.9287918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-C07:10KRAEVESVF0.9130.9588918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B39:12KRAEVESVF0.90020.8302918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B35:12EVESVFETL0.70730.96841221
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-C12:16KRAEVESVF0.0910.8908918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B40:06AEVESVFETL0.99940.70081121
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B44:10AEVESVFETL0.99730.60771121
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B40:03AEVESVFETL0.99490.54221121
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B39:08AEVESVFETL0.96430.79261121
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B08:18EMLKRAEV0.99950.9198614
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B27:10KRAEVESVF0.99930.9158918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B27:08KRAEVESVF0.99920.742918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B27:06KRAEVESVF0.99910.8373918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-C07:01KRAEVESVF0.99810.6394918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B27:09KRAEVESVF0.99440.7812918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-A68:02EVESVFETL0.98740.57191221
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-A25:01EVESVFETL0.98670.82951221
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-C07:17KRAEVESVF0.9810.9424918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-A69:01EVESVFETL0.94430.8131221
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-C07:02KRAEVESVF0.93310.9287918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B40:04AEVESVFET0.91970.77881120
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B41:03WEMLKRAEV0.91410.9294514
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-C07:22KRAEVESVF0.88750.5478918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B39:31KRAEVESVF0.88210.8232918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-C07:04KRAEVESVF0.82950.8438918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B38:05KRAEVESVF0.78160.8983918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-C06:08KRAEVESVF0.75720.9809918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B35:09EVESVFETL0.70730.96841221
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B48:02KRAEVESVF0.43490.9262918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-C06:06KRAEVESVF0.23610.974918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B15:68KRAEVESVF0.19460.6672918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B50:05AEVESVFET0.1710.79381120
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B50:04AEVESVFET0.1710.79381120
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B15:54KRAEVESVF0.15350.8677918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-C03:67KRAEVESVF0.12150.9816918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-C06:02KRAEVESVF0.06450.9787918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-C06:17KRAEVESVF0.06450.9787918
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B40:04AEVESVFETL0.99910.75841121
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B44:07AEVESVFETL0.9980.98791121
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B44:26AEVESVFETL0.9980.98791121
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B44:13AEVESVFETL0.9980.98791121
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-A68:02EVESVFETLV0.99480.73431222
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B15:68LKRAEVESVF0.98750.6339818
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B15:54LKRAEVESVF0.98580.8763818
CDC42BPA-HYOU1chr1227400837chr111189205491297HLA-B39:02AEVESVFETL0.89330.96651121

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Potential FusionNeoAntigen Information of CDC42BPA-HYOU1 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
CDC42BPA-HYOU1_227400837_118920549.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0801ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0801LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0802ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0802LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0803ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0803LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0805ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0805LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0807ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0807LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0807KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0807NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0808ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0808LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0808KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0808NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0809ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0809LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0811ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0811LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0811KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0811NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0813LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0813ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0814ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0814LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0815LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0815ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0816ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0816LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0818ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0818LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0819LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0819ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0821ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0821LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0823ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0823LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0824ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0824LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0825ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0825LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0826ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0826LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0827ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0827LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0829ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0829LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0830LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0830ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0832ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0832LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0833ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0833LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0834ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0834LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0835ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0835LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0836ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0836LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0837ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0837LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0838ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0838LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0839ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-0839LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1101ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1101LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1101NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1105ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1105LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1105NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1105KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1108LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1108ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1108NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1108KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1109ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1109LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1109NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1110ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1110LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1110NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1111LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1111ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1112ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1112LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1112NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1115ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1115LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1115NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1119LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1119ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1119NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1119KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1124ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1124LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1124NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1127LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1127ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1127NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1127KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1128ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1128LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1128NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1129ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1129LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1129NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1130LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1131LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1131ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1131NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1131KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1132LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1132ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1132NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1132KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1133ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1133LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1133NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1137ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1137LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1137NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1137KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1139ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1139LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1139NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1145LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1145ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1149ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1149LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1149NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1151ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1151LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1151NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1161ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1161LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1161NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1162ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1162LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1162NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1164LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1164ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1166ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1166LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1166NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1169LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1169ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1172LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1172ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1172NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1172KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1173LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1173ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1174ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1174LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1174NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1175ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1175LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1175NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1180ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1180LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1181ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1181LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1181NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1187ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1187LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1190ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1190LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1190NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1191ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1191LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1193ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1193LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1194ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1194LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1194NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1195ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1195LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1195NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1196ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1196LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1196NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1216ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1216LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1216KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1305ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1305LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1305NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1307ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1307LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1307NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1307KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-13100ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-13100LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-13100KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-13100NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-13101ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-13101LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1310ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1310LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1312ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1312LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1313ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1313LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1314ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1314LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1314NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1321ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1321LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1326LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1326ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1326NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1326KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1330ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1330LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1337ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1337LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1346ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1346LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1346KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1346NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1347LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1347ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1347NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1349ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1349LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1350ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1350LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1350NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1355ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1355LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1356LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1356ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1356NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1356KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1360ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1360LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1362ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1362LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1362NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1363LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1363ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1382LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1382ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1382NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1382KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1385LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1385ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1386LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1386ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1386NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1386KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1402LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1402ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1402NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1403LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1403ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1403NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1407ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1407LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1407KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1407NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1409LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1409ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1413ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1413LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1413KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1413NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1414LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1414ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1414KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1414NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1422ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1422LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1422KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1422NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1425ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1425LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1425KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1425NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1427LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1427ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1427NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1427KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1430LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1430ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1430NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1430KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1436LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1436ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1436KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1436NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1440LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1440ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1440NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1441LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1441ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1441NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1442LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1442ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1442NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1442KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1444LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1444ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1444KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1444NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1448LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1448ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1449LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1449ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1449KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1449NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1451LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1451ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1453ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1453LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1453KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1453NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1463ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1463LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1463KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1463NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1467LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1467ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1468ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1468LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1468KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1468NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1469ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1469LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1469KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1469NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1477LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1477ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1477NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1485ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1485LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1485KILNKWEMLKRAEVE015
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1485NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1489LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1489ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1493ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1493LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1494LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1494ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1494NKWEMLKRAEVESVF318
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1498LNKWEMLKRAEVESV217
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1498ILNKWEMLKRAEVES116
CDC42BPA-HYOU1chr1227400837chr111189205491297DRB1-1523RAEVESVFETLVEDS1025

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Fusion breakpoint peptide structures of CDC42BPA-HYOU1

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
1958EMLKRAEVESVFETCDC42BPAHYOU1chr1227400837chr111189205491297

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of CDC42BPA-HYOU1

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN1958EMLKRAEVESVFET-6.81784-6.93724
HLA-B14:023BVN1958EMLKRAEVESVFET-5.72956-6.77086
HLA-B52:013W391958EMLKRAEVESVFET-7.39683-7.51623
HLA-B52:013W391958EMLKRAEVESVFET-6.35068-7.39198
HLA-A11:014UQ21958EMLKRAEVESVFET-2.93775-3.05715
HLA-A24:025HGA1958EMLKRAEVESVFET-8.28894-8.40834
HLA-A24:025HGA1958EMLKRAEVESVFET-6.60463-7.64593
HLA-B44:053DX81958EMLKRAEVESVFET-6.05305-6.17245
HLA-B44:053DX81958EMLKRAEVESVFET-2.83839-3.87969
HLA-A02:016TDR1958EMLKRAEVESVFET-7.33893-7.45833

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Vaccine Design for the FusionNeoAntigens of CDC42BPA-HYOU1

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
CDC42BPA-HYOU1chr1227400837chr111189205491120AEVESVFETGCTGAGGTGGAGTCTGTATTTGAGACA
CDC42BPA-HYOU1chr1227400837chr111189205491121AEVESVFETLGCTGAGGTGGAGTCTGTATTTGAGACACTG
CDC42BPA-HYOU1chr1227400837chr111189205491221EVESVFETLGAGGTGGAGTCTGTATTTGAGACACTG
CDC42BPA-HYOU1chr1227400837chr111189205491222EVESVFETLVGAGGTGGAGTCTGTATTTGAGACACTGGTA
CDC42BPA-HYOU1chr1227400837chr11118920549514WEMLKRAEVTGGGAAATGCTGAAAAGAGCTGAGGTG
CDC42BPA-HYOU1chr1227400837chr11118920549614EMLKRAEVGAAATGCTGAAAAGAGCTGAGGTG
CDC42BPA-HYOU1chr1227400837chr11118920549718MLKRAEVESVFATGCTGAAAAGAGCTGAGGTGGAGTCTGTATTT
CDC42BPA-HYOU1chr1227400837chr11118920549818LKRAEVESVFCTGAAAAGAGCTGAGGTGGAGTCTGTATTT
CDC42BPA-HYOU1chr1227400837chr11118920549918KRAEVESVFAAAAGAGCTGAGGTGGAGTCTGTATTT

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
CDC42BPA-HYOU1chr1227400837chr11118920549015KILNKWEMLKRAEVEAAAATATTGAATAAATGGGAAATGCTGAAAAGAGCTGAGGTGGAG
CDC42BPA-HYOU1chr1227400837chr11118920549116ILNKWEMLKRAEVESATATTGAATAAATGGGAAATGCTGAAAAGAGCTGAGGTGGAGTCT
CDC42BPA-HYOU1chr1227400837chr111189205491025RAEVESVFETLVEDSAGAGCTGAGGTGGAGTCTGTATTTGAGACACTGGTAGAGGACAGC
CDC42BPA-HYOU1chr1227400837chr11118920549217LNKWEMLKRAEVESVTTGAATAAATGGGAAATGCTGAAAAGAGCTGAGGTGGAGTCTGTA
CDC42BPA-HYOU1chr1227400837chr11118920549318NKWEMLKRAEVESVFAATAAATGGGAAATGCTGAAAAGAGCTGAGGTGGAGTCTGTATTT

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Information of the samples that have these potential fusion neoantigens of CDC42BPA-HYOU1

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
GBMCDC42BPA-HYOU1chr1227400837ENST00000334218chr11118920549ENST00000404233TCGA-32-1982-01A

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Potential target of CAR-T therapy development for CDC42BPA-HYOU1

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to CDC42BPA-HYOU1

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CDC42BPA-HYOU1

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource