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Fusion Protein:CDH23-NSD1 |
Fusion Gene and Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: CDH23-NSD1 | FusionPDB ID: 15062 | FusionGDB2.0 ID: 15062 | Hgene | Tgene | Gene symbol | CDH23 | NSD1 | Gene ID | 64072 | 64324 |
Gene name | cadherin related 23 | nuclear receptor binding SET domain protein 1 | |
Synonyms | CDHR23|PITA5|USH1D | ARA267|KMT3B|SOTOS|SOTOS1|STO | |
Cytomap | 10q22.1 | 5q35.3 | |
Type of gene | protein-coding | protein-coding | |
Description | cadherin-23cadherin-like 23cadherin-related family member 23otocadherin | histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificH3-K36-HMTaseH4-K20-HMTaseNR-binding SET domain-containing proteinandrogen receptor coactivator 267 kDa proteinandrogen receptor-associated coregulator 267androgen receptor-as | |
Modification date | 20200320 | 20200321 | |
UniProtAcc | Q9H251 Main function of 5'-partner protein: FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. {ECO:0000269|PubMed:11138009, ECO:0000269|PubMed:16679490}. | . | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000224721, ENST00000299366, ENST00000398788, ENST00000398809, ENST00000398842, ENST00000461841, ENST00000475158, | ENST00000361032, ENST00000511258, ENST00000347982, ENST00000354179, ENST00000439151, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 7 X 7 X 2=98 | 12 X 14 X 7=1176 |
# samples | 7 | 17 | |
** MAII score | log2(7/98*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(17/1176*10)=-2.79028140869866 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Fusion gene context | PubMed: CDH23 [Title/Abstract] AND NSD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Fusion neoantigen context | PubMed: CDH23 [Title/Abstract] AND NSD1 [Title/Abstract] AND neoantigen [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | NSD1(176563031)-CDH23(73434869), # samples:3 CDH23(73501678)-NSD1(176618885), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | CDH23-NSD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CDH23-NSD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CDH23-NSD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CDH23-NSD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | NSD1 | GO:0045893 | positive regulation of transcription, DNA-templated | 11509567 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:176563031/chr5:73434869) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Amino Acid Sequences |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000224721 | CDH23 | chr10 | 73501678 | + | ENST00000354179 | NSD1 | chr5 | 176618885 | + | 16780 | 4865 | 5 | 12028 | 4007 |
ENST00000224721 | CDH23 | chr10 | 73501678 | + | ENST00000439151 | NSD1 | chr5 | 176618885 | + | 16785 | 4865 | 5 | 12028 | 4007 |
ENST00000224721 | CDH23 | chr10 | 73501678 | + | ENST00000347982 | NSD1 | chr5 | 176618885 | + | 12332 | 4865 | 5 | 12028 | 4007 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000224721 | ENST00000354179 | CDH23 | chr10 | 73501678 | + | NSD1 | chr5 | 176618885 | + | 0.000261953 | 0.99973804 |
ENST00000224721 | ENST00000439151 | CDH23 | chr10 | 73501678 | + | NSD1 | chr5 | 176618885 | + | 0.000261996 | 0.99973804 |
ENST00000224721 | ENST00000347982 | CDH23 | chr10 | 73501678 | + | NSD1 | chr5 | 176618885 | + | 0.000503795 | 0.9994962 |
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Get the fusion protein sequences from here. |
Fusion protein sequence information is available in the fasta format. >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP |
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Fusion Protein Breakpoint Sequences for CDH23-NSD1 |
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Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Length(fusion protein) | BP in fusion protein | Peptide |
CDH23 | chr10 | 73501678 | NSD1 | chr5 | 176618885 | 4865 | 1618 | HLVATVEDEGTPTLSCQPKKKSTPLK |
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Potential FusionNeoAntigen Information of CDH23-NSD1 in HLA I |
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CDH23-NSD1_73501678_176618885.msa |
![]() * We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5) |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA I | FusionNeoAntigen peptide | Binding score | Immunogenic score | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B13:01 | VEDEGTPTL | 0.9756 | 0.9535 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B50:02 | VEDEGTPTL | 0.9176 | 0.5541 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B44:03 | VEDEGTPTL | 0.7359 | 0.9527 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B45:01 | VEDEGTPTL | 0.6231 | 0.7338 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B18:01 | VEDEGTPTL | 0.5922 | 0.9596 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:13 | VEDEGTPTL | 0.5823 | 0.9678 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:01 | VEDEGTPTL | 0.5817 | 0.9637 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B38:01 | VEDEGTPTL | 0.5384 | 0.9649 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B38:02 | VEDEGTPTL | 0.5196 | 0.9692 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B15:37 | VEDEGTPTL | 0.4669 | 0.7529 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B15:10 | VEDEGTPTL | 0.3355 | 0.6787 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B41:01 | VEDEGTPTL | 0.3056 | 0.8675 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B50:01 | VEDEGTPTL | 0.2907 | 0.7848 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B35:04 | VEDEGTPTL | 0.2189 | 0.9802 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B35:02 | VEDEGTPTL | 0.2189 | 0.9802 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:13 | TVEDEGTPTL | 0.4899 | 0.9647 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B41:01 | TVEDEGTPTL | 0.2579 | 0.8851 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-A02:21 | TVEDEGTPTL | 0.2301 | 0.6314 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B41:01 | ATVEDEGTPTL | 0.9386 | 0.9059 | 3 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:13 | ATVEDEGTPTL | 0.922 | 0.9581 | 3 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:08 | EDEGTPTL | 0.9435 | 0.7302 | 6 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C05:09 | VEDEGTPTL | 0.9997 | 0.9218 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C04:07 | VEDEGTPTL | 0.9996 | 0.7167 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C04:10 | VEDEGTPTL | 0.9996 | 0.7182 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C08:15 | VEDEGTPTL | 0.9995 | 0.957 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B40:06 | VEDEGTPTL | 0.9986 | 0.7286 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C08:03 | VEDEGTPTL | 0.8884 | 0.971 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C08:13 | VEDEGTPTL | 0.7785 | 0.9669 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C08:04 | VEDEGTPTL | 0.7785 | 0.9669 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C04:14 | VEDEGTPTL | 0.6991 | 0.7441 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:09 | VEDEGTPTL | 0.692 | 0.71 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:08 | VEDEGTPTL | 0.6827 | 0.8017 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B14:03 | VEDEGTPTL | 0.6468 | 0.8914 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:10 | VEDEGTPTL | 0.6037 | 0.9535 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C07:13 | VEDEGTPTL | 0.5824 | 0.961 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C07:29 | VEDEGTPTL | 0.5285 | 0.9604 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:05 | VEDEGTPTL | 0.5055 | 0.9559 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:12 | VEDEGTPTL | 0.4875 | 0.9664 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B35:12 | VEDEGTPTL | 0.2189 | 0.9802 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B51:07 | VEDEGTPTL | 0.025 | 0.9186 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C05:09 | TVEDEGTPTL | 0.9999 | 0.9271 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C04:10 | TVEDEGTPTL | 0.9999 | 0.7434 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C08:15 | TVEDEGTPTL | 0.9999 | 0.9631 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C04:06 | TVEDEGTPTL | 0.9554 | 0.9268 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C08:04 | TVEDEGTPTL | 0.9242 | 0.9748 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C08:13 | TVEDEGTPTL | 0.9242 | 0.9748 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:08 | TVEDEGTPTL | 0.8631 | 0.8565 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C08:03 | TVEDEGTPTL | 0.7895 | 0.9685 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:08 | VEDEGTPTLS | 0.7557 | 0.774 | 5 | 15 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:09 | TVEDEGTPTL | 0.6705 | 0.703 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:05 | TVEDEGTPTL | 0.4544 | 0.9477 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-A02:07 | TVEDEGTPTL | 0.2041 | 0.5168 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C05:09 | ATVEDEGTPTL | 1 | 0.9359 | 3 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C08:15 | ATVEDEGTPTL | 1 | 0.973 | 3 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:08 | ATVEDEGTPTL | 0.9961 | 0.8569 | 3 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B48:03 | ATVEDEGTPTL | 0.9539 | 0.5065 | 3 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B44:10 | ATVEDEGTPTL | 0.8361 | 0.6622 | 3 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:11 | EDEGTPTL | 0.9455 | 0.6807 | 6 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C05:01 | VEDEGTPTL | 0.9997 | 0.9218 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C04:03 | VEDEGTPTL | 0.9997 | 0.7552 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C04:01 | VEDEGTPTL | 0.9996 | 0.7167 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C08:02 | VEDEGTPTL | 0.9995 | 0.957 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C18:01 | VEDEGTPTL | 0.9995 | 0.7087 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B40:04 | VEDEGTPTL | 0.9988 | 0.7607 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C08:01 | VEDEGTPTL | 0.8884 | 0.971 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C04:04 | VEDEGTPTL | 0.7871 | 0.8822 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B44:26 | VEDEGTPTL | 0.7359 | 0.9527 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B44:13 | VEDEGTPTL | 0.7359 | 0.9527 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B44:07 | VEDEGTPTL | 0.7359 | 0.9527 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C03:67 | VEDEGTPTL | 0.6841 | 0.9889 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:02 | VEDEGTPTL | 0.6425 | 0.969 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B18:07 | VEDEGTPTL | 0.6248 | 0.9327 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:11 | VEDEGTPTL | 0.6224 | 0.7472 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B18:05 | VEDEGTPTL | 0.5922 | 0.9596 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:31 | VEDEGTPTL | 0.5922 | 0.9633 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B18:04 | VEDEGTPTL | 0.5922 | 0.9626 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B38:05 | VEDEGTPTL | 0.5384 | 0.9649 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B18:06 | VEDEGTPTL | 0.5293 | 0.9647 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B18:08 | VEDEGTPTL | 0.5258 | 0.9524 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C07:04 | VEDEGTPTL | 0.5186 | 0.8914 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B18:03 | VEDEGTPTL | 0.5086 | 0.9536 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B18:11 | VEDEGTPTL | 0.5011 | 0.9249 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B41:03 | VEDEGTPTL | 0.4893 | 0.5024 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-A02:14 | VEDEGTPTL | 0.3982 | 0.5386 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B48:02 | VEDEGTPTL | 0.3736 | 0.9455 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B35:13 | VEDEGTPTL | 0.3617 | 0.9271 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B50:05 | VEDEGTPTL | 0.2907 | 0.7848 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B50:04 | VEDEGTPTL | 0.2907 | 0.7848 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B35:09 | VEDEGTPTL | 0.2189 | 0.9802 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B15:09 | VEDEGTPTL | 0.2172 | 0.6939 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B35:20 | VEDEGTPTL | 0.1368 | 0.9598 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B07:13 | VEDEGTPTL | 0.0076 | 0.7281 | 5 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C08:02 | TVEDEGTPTL | 0.9999 | 0.9631 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C05:01 | TVEDEGTPTL | 0.9999 | 0.9271 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C04:03 | TVEDEGTPTL | 0.9999 | 0.7865 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C03:06 | TVEDEGTPTL | 0.8566 | 0.9958 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:11 | TVEDEGTPTL | 0.8301 | 0.8124 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C08:01 | TVEDEGTPTL | 0.7895 | 0.9685 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B07:13 | TVEDEGTPTL | 0.7386 | 0.811 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:02 | TVEDEGTPTL | 0.6538 | 0.9661 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B40:04 | TVEDEGTPTL | 0.4334 | 0.7628 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B41:03 | TVEDEGTPTL | 0.3889 | 0.5443 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-A69:01 | TVEDEGTPTL | 0.3008 | 0.6953 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-A02:14 | TVEDEGTPTL | 0.2404 | 0.5205 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-A02:06 | TVEDEGTPTL | 0.2301 | 0.6314 | 4 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C08:02 | ATVEDEGTPTL | 1 | 0.973 | 3 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C04:03 | ATVEDEGTPTL | 1 | 0.8104 | 3 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-C05:01 | ATVEDEGTPTL | 1 | 0.9359 | 3 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:11 | ATVEDEGTPTL | 0.9848 | 0.8143 | 3 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B40:21 | ATVEDEGTPTL | 0.982 | 0.536 | 3 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B40:04 | ATVEDEGTPTL | 0.9812 | 0.765 | 3 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B41:03 | ATVEDEGTPTL | 0.9584 | 0.5682 | 3 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B40:12 | ATVEDEGTPTL | 0.9539 | 0.5065 | 3 | 14 |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 | HLA-B39:02 | ATVEDEGTPTL | 0.9486 | 0.9574 | 3 | 14 |
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Potential FusionNeoAntigen Information of CDH23-NSD1 in HLA II |
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![]() * We used NetMHCIIpan v4.1 (%rank<0.5). |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA II | FusionNeoAntigen peptide | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
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Fusion breakpoint peptide structures of CDH23-NSD1 |
![]() * The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA. |
File name | BPseq | Hgene | Tgene | Hchr | Hbp | Tchr | Tbp | AAlen |
1578 | EDEGTPTLSCQPKK | CDH23 | NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4865 |
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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of CDH23-NSD1 |
![]() * We used Glide to predict the interaction between HLAs and neoantigens. |
HLA allele | PDB ID | File name | BPseq | Docking score | Glide score |
HLA-B14:02 | 3BVN | 1578 | EDEGTPTLSCQPKK | -7.69222 | -7.69942 |
HLA-B52:01 | 3W39 | 1578 | EDEGTPTLSCQPKK | -7.60148 | -7.60868 |
HLA-A11:01 | 4UQ2 | 1578 | EDEGTPTLSCQPKK | -6.66327 | -6.67047 |
HLA-A24:02 | 5HGA | 1578 | EDEGTPTLSCQPKK | -9.4375 | -9.4447 |
HLA-B27:05 | 6PYJ | 1578 | EDEGTPTLSCQPKK | -4.77117 | -4.77837 |
HLA-B44:05 | 3DX8 | 1578 | EDEGTPTLSCQPKK | -6.68497 | -6.69217 |
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Vaccine Design for the FusionNeoAntigens of CDH23-NSD1 |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide sequence | FusionNeoAntigen RNA sequence |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 3 | 14 | ATVEDEGTPTL | GTGGAGGACGAGGGCACCCCAACCCTGTCGTGT |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 4 | 14 | TVEDEGTPTL | GAGGACGAGGGCACCCCAACCCTGTCGTGT |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 5 | 14 | VEDEGTPTL | GACGAGGGCACCCCAACCCTGTCGTGT |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 5 | 15 | VEDEGTPTLS | GACGAGGGCACCCCAACCCTGTCGTGTCAA |
CDH23-NSD1 | chr10 | 73501678 | chr5 | 176618885 | 6 | 14 | EDEGTPTL | GAGGGCACCCCAACCCTGTCGTGT |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide | FusionNEoAntigen RNA sequence |
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Information of the samples that have these potential fusion neoantigens of CDH23-NSD1 |
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Cancer type | Fusion gene | Hchr | Hbp | Henst | Tchr | Tbp | Tenst | Sample |
BRCA | CDH23-NSD1 | chr10 | 73501678 | ENST00000224721 | chr5 | 176618885 | ENST00000347982 | TCGA-AN-A0FJ-01A |
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Potential target of CAR-T therapy development for CDH23-NSD1 |
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![]() * Minus value of BPloci means that the break point is located before the CDS. |
- In-frame and retained 'Transmembrane'. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
![]() * We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image. |
Hgene | Hchr | Hbp | Henst | Tgene | Tchr | Tbp | Tenst | DeepLoc result |
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Related Drugs to CDH23-NSD1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to CDH23-NSD1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |