FusionNeoAntigen Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine
leaf

Fusion Gene and Fusion Protein Summary

leaf

Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

leaf

Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

leaf

Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

leaf

Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

leaf

Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

leaf

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

leaf

Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

leaf

Potential target of CAR-T therapy development

leaf

Information on the samples that have these potential fusion neoantigens

leaf

Fusion Protein Targeting Drugs - (Manual Curation)

leaf

Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:CHD7-TCF7L2

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CHD7-TCF7L2
FusionPDB ID: 16382
FusionGDB2.0 ID: 16382
HgeneTgene
Gene symbol

CHD7

TCF7L2

Gene ID

55636

6934

Gene namechromodomain helicase DNA binding protein 7transcription factor 7 like 2
SynonymsCRG|HH5|IS3|KAL5TCF-4|TCF4
Cytomap

8q12.2

10q25.2-q25.3

Type of geneprotein-codingprotein-coding
Descriptionchromodomain-helicase-DNA-binding protein 7ATP-dependent helicase CHD7CHARGE associationchromodomain helicase DNA binding protein 7 isoform CRA_etranscription factor 7-like 2HMG box transcription factor 4T-cell factor 4T-cell-specific transcription factor 4hTCF-4transcription factor 7-like 2 (T-cell specific, HMG-box)
Modification date2020032820200315
UniProtAcc

Q9P2D1

Main function of 5'-partner protein: FUNCTION: Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239}.

Q9NQB0

Main function of 5'-partner protein: FUNCTION: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. {ECO:0000269|PubMed:12408868, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:19443654, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:9727977}.
Ensembl transtripts involved in fusion geneENST idsENST00000423902, ENST00000524602, 
ENST00000525508, ENST00000529472, 
ENST00000542695, ENST00000369386, 
ENST00000369389, ENST00000466338, 
ENST00000349937, ENST00000352065, 
ENST00000355717, ENST00000355995, 
ENST00000369395, ENST00000369397, 
ENST00000534894, ENST00000536810, 
ENST00000538897, ENST00000543371, 
ENST00000545257, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 8 X 8=76812 X 11 X 10=1320
# samples 1717
** MAII scorelog2(17/768*10)=-2.17557156458345
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1320*10)=-2.95693127810811
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: CHD7 [Title/Abstract] AND TCF7L2 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: CHD7 [Title/Abstract] AND TCF7L2 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CHD7(61655656)-TCF7L2(114900943), # samples:3
TCF7L2(114799885)-CHD7(61693559), # samples:3
Anticipated loss of major functional domain due to fusion event.CHD7-TCF7L2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHD7-TCF7L2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHD7-TCF7L2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CHD7-TCF7L2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TCF7L2-CHD7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TCF7L2-CHD7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTCF7L2

GO:0000122

negative regulation of transcription by RNA polymerase II

12799378

TgeneTCF7L2

GO:0006357

regulation of transcription by RNA polymerase II

9727977

TgeneTCF7L2

GO:0032092

positive regulation of protein binding

12799378

TgeneTCF7L2

GO:0032350

regulation of hormone metabolic process

15525634

TgeneTCF7L2

GO:0042593

glucose homeostasis

15525634

TgeneTCF7L2

GO:0043433

negative regulation of DNA-binding transcription factor activity

12799378

TgeneTCF7L2

GO:0045444

fat cell differentiation

10937998

TgeneTCF7L2

GO:0045892

negative regulation of transcription, DNA-templated

12799378|15525634

TgeneTCF7L2

GO:0045944

positive regulation of transcription by RNA polymerase II

9065401|19168596

TgeneTCF7L2

GO:0048625

myoblast fate commitment

10937998



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:61655656/chr10:114900943)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across CHD7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TCF7L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000423902CHD7chr861655656+ENST00000534894TCF7L2chr10114900943+307721444463076877
ENST00000423902CHD7chr861655656+ENST00000536810TCF7L2chr10114900943+510721444463400984
ENST00000423902CHD7chr861655656+ENST00000545257TCF7L2chr10114900943+5158214444634511001
ENST00000423902CHD7chr861655656+ENST00000355995TCF7L2chr10114900943+5158214444634511001
ENST00000423902CHD7chr861655656+ENST00000543371TCF7L2chr10114900943+510721444463400984
ENST00000423902CHD7chr861655656+ENST00000355717TCF7L2chr10114900943+503421444462989847
ENST00000423902CHD7chr861655656+ENST00000538897TCF7L2chr10114900943+508521444463040864
ENST00000423902CHD7chr861655656+ENST00000349937TCF7L2chr10114900943+246121444462458670
ENST00000423902CHD7chr861655656+ENST00000369397TCF7L2chr10114900943+5158214444634511001
ENST00000423902CHD7chr861655656+ENST00000352065TCF7L2chr10114900943+311721444463040864
ENST00000423902CHD7chr861655656+ENST00000369395TCF7L2chr10114900943+247321444462470674
ENST00000524602CHD7chr861655656+ENST00000534894TCF7L2chr10114900943+26661733352665877
ENST00000524602CHD7chr861655656+ENST00000536810TCF7L2chr10114900943+46961733352989984
ENST00000524602CHD7chr861655656+ENST00000545257TCF7L2chr10114900943+474717333530401001
ENST00000524602CHD7chr861655656+ENST00000355995TCF7L2chr10114900943+474717333530401001
ENST00000524602CHD7chr861655656+ENST00000543371TCF7L2chr10114900943+46961733352989984
ENST00000524602CHD7chr861655656+ENST00000355717TCF7L2chr10114900943+46231733352578847
ENST00000524602CHD7chr861655656+ENST00000538897TCF7L2chr10114900943+46741733352629864
ENST00000524602CHD7chr861655656+ENST00000349937TCF7L2chr10114900943+20501733352047670
ENST00000524602CHD7chr861655656+ENST00000369397TCF7L2chr10114900943+474717333530401001
ENST00000524602CHD7chr861655656+ENST00000352065TCF7L2chr10114900943+27061733352629864
ENST00000524602CHD7chr861655656+ENST00000369395TCF7L2chr10114900943+20621733352059674
ENST00000525508CHD7chr861655656+ENST00000534894TCF7L2chr10114900943+2598166502597865
ENST00000525508CHD7chr861655656+ENST00000536810TCF7L2chr10114900943+4628166502921973
ENST00000525508CHD7chr861655656+ENST00000545257TCF7L2chr10114900943+4679166502972990
ENST00000525508CHD7chr861655656+ENST00000355995TCF7L2chr10114900943+4679166502972990
ENST00000525508CHD7chr861655656+ENST00000543371TCF7L2chr10114900943+4628166502921973
ENST00000525508CHD7chr861655656+ENST00000355717TCF7L2chr10114900943+4555166502510836
ENST00000525508CHD7chr861655656+ENST00000538897TCF7L2chr10114900943+4606166502561853
ENST00000525508CHD7chr861655656+ENST00000349937TCF7L2chr10114900943+1982166501979659
ENST00000525508CHD7chr861655656+ENST00000369397TCF7L2chr10114900943+4679166502972990
ENST00000525508CHD7chr861655656+ENST00000352065TCF7L2chr10114900943+2638166502561853
ENST00000525508CHD7chr861655656+ENST00000369395TCF7L2chr10114900943+1994166501991663
ENST00000423902CHD7chr861655656+ENST00000534894TCF7L2chr10114900942+307721444463076877
ENST00000423902CHD7chr861655656+ENST00000536810TCF7L2chr10114900942+510721444463400984
ENST00000423902CHD7chr861655656+ENST00000545257TCF7L2chr10114900942+5158214444634511001
ENST00000423902CHD7chr861655656+ENST00000355995TCF7L2chr10114900942+5158214444634511001
ENST00000423902CHD7chr861655656+ENST00000543371TCF7L2chr10114900942+510721444463400984
ENST00000423902CHD7chr861655656+ENST00000355717TCF7L2chr10114900942+503421444462989847
ENST00000423902CHD7chr861655656+ENST00000538897TCF7L2chr10114900942+508521444463040864
ENST00000423902CHD7chr861655656+ENST00000349937TCF7L2chr10114900942+246121444462458670
ENST00000423902CHD7chr861655656+ENST00000369397TCF7L2chr10114900942+5158214444634511001
ENST00000423902CHD7chr861655656+ENST00000352065TCF7L2chr10114900942+311721444463040864
ENST00000423902CHD7chr861655656+ENST00000369395TCF7L2chr10114900942+247321444462470674
ENST00000524602CHD7chr861655656+ENST00000534894TCF7L2chr10114900942+26661733352665877
ENST00000524602CHD7chr861655656+ENST00000536810TCF7L2chr10114900942+46961733352989984
ENST00000524602CHD7chr861655656+ENST00000545257TCF7L2chr10114900942+474717333530401001
ENST00000524602CHD7chr861655656+ENST00000355995TCF7L2chr10114900942+474717333530401001
ENST00000524602CHD7chr861655656+ENST00000543371TCF7L2chr10114900942+46961733352989984
ENST00000524602CHD7chr861655656+ENST00000355717TCF7L2chr10114900942+46231733352578847
ENST00000524602CHD7chr861655656+ENST00000538897TCF7L2chr10114900942+46741733352629864
ENST00000524602CHD7chr861655656+ENST00000349937TCF7L2chr10114900942+20501733352047670
ENST00000524602CHD7chr861655656+ENST00000369397TCF7L2chr10114900942+474717333530401001
ENST00000524602CHD7chr861655656+ENST00000352065TCF7L2chr10114900942+27061733352629864
ENST00000524602CHD7chr861655656+ENST00000369395TCF7L2chr10114900942+20621733352059674
ENST00000525508CHD7chr861655656+ENST00000534894TCF7L2chr10114900942+2598166502597865
ENST00000525508CHD7chr861655656+ENST00000536810TCF7L2chr10114900942+4628166502921973
ENST00000525508CHD7chr861655656+ENST00000545257TCF7L2chr10114900942+4679166502972990
ENST00000525508CHD7chr861655656+ENST00000355995TCF7L2chr10114900942+4679166502972990
ENST00000525508CHD7chr861655656+ENST00000543371TCF7L2chr10114900942+4628166502921973
ENST00000525508CHD7chr861655656+ENST00000355717TCF7L2chr10114900942+4555166502510836
ENST00000525508CHD7chr861655656+ENST00000538897TCF7L2chr10114900942+4606166502561853
ENST00000525508CHD7chr861655656+ENST00000349937TCF7L2chr10114900942+1982166501979659
ENST00000525508CHD7chr861655656+ENST00000369397TCF7L2chr10114900942+4679166502972990
ENST00000525508CHD7chr861655656+ENST00000352065TCF7L2chr10114900942+2638166502561853
ENST00000525508CHD7chr861655656+ENST00000369395TCF7L2chr10114900942+1994166501991663

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000423902ENST00000534894CHD7chr861655656+TCF7L2chr10114900943+0.0094963650.9905036
ENST00000423902ENST00000536810CHD7chr861655656+TCF7L2chr10114900943+0.0008714840.9991285
ENST00000423902ENST00000545257CHD7chr861655656+TCF7L2chr10114900943+0.000956650.9990433
ENST00000423902ENST00000355995CHD7chr861655656+TCF7L2chr10114900943+0.0009793660.9990206
ENST00000423902ENST00000543371CHD7chr861655656+TCF7L2chr10114900943+0.0008761150.9991239
ENST00000423902ENST00000355717CHD7chr861655656+TCF7L2chr10114900943+0.0012323940.9987676
ENST00000423902ENST00000538897CHD7chr861655656+TCF7L2chr10114900943+0.0011514240.99884856
ENST00000423902ENST00000349937CHD7chr861655656+TCF7L2chr10114900943+0.018043310.9819567
ENST00000423902ENST00000369397CHD7chr861655656+TCF7L2chr10114900943+0.0009793660.9990206
ENST00000423902ENST00000352065CHD7chr861655656+TCF7L2chr10114900943+0.009965870.99003416
ENST00000423902ENST00000369395CHD7chr861655656+TCF7L2chr10114900943+0.0176417770.98235816
ENST00000524602ENST00000534894CHD7chr861655656+TCF7L2chr10114900943+0.0095500030.99044997
ENST00000524602ENST00000536810CHD7chr861655656+TCF7L2chr10114900943+0.0005720460.999428
ENST00000524602ENST00000545257CHD7chr861655656+TCF7L2chr10114900943+0.0005298730.9994702
ENST00000524602ENST00000355995CHD7chr861655656+TCF7L2chr10114900943+0.0005386330.99946135
ENST00000524602ENST00000543371CHD7chr861655656+TCF7L2chr10114900943+0.0005789630.999421
ENST00000524602ENST00000355717CHD7chr861655656+TCF7L2chr10114900943+0.0010910780.9989089
ENST00000524602ENST00000538897CHD7chr861655656+TCF7L2chr10114900943+0.0010151150.9989849
ENST00000524602ENST00000349937CHD7chr861655656+TCF7L2chr10114900943+0.0141093340.9858906
ENST00000524602ENST00000369397CHD7chr861655656+TCF7L2chr10114900943+0.0005386330.99946135
ENST00000524602ENST00000352065CHD7chr861655656+TCF7L2chr10114900943+0.010045320.9899547
ENST00000524602ENST00000369395CHD7chr861655656+TCF7L2chr10114900943+0.0139146170.9860854
ENST00000525508ENST00000534894CHD7chr861655656+TCF7L2chr10114900943+0.0090094810.9909905
ENST00000525508ENST00000536810CHD7chr861655656+TCF7L2chr10114900943+0.0005434310.9994566
ENST00000525508ENST00000545257CHD7chr861655656+TCF7L2chr10114900943+0.0005023270.99949765
ENST00000525508ENST00000355995CHD7chr861655656+TCF7L2chr10114900943+0.0005103280.99948967
ENST00000525508ENST00000543371CHD7chr861655656+TCF7L2chr10114900943+0.0005496080.9994504
ENST00000525508ENST00000355717CHD7chr861655656+TCF7L2chr10114900943+0.001033370.9989667
ENST00000525508ENST00000538897CHD7chr861655656+TCF7L2chr10114900943+0.0009604640.9990395
ENST00000525508ENST00000349937CHD7chr861655656+TCF7L2chr10114900943+0.0128631970.98713684
ENST00000525508ENST00000369397CHD7chr861655656+TCF7L2chr10114900943+0.0005103280.99948967
ENST00000525508ENST00000352065CHD7chr861655656+TCF7L2chr10114900943+0.0095107370.99048924
ENST00000525508ENST00000369395CHD7chr861655656+TCF7L2chr10114900943+0.0127282550.9872717
ENST00000423902ENST00000534894CHD7chr861655656+TCF7L2chr10114900942+0.0094963650.9905036
ENST00000423902ENST00000536810CHD7chr861655656+TCF7L2chr10114900942+0.0008714840.9991285
ENST00000423902ENST00000545257CHD7chr861655656+TCF7L2chr10114900942+0.000956650.9990433
ENST00000423902ENST00000355995CHD7chr861655656+TCF7L2chr10114900942+0.0009793660.9990206
ENST00000423902ENST00000543371CHD7chr861655656+TCF7L2chr10114900942+0.0008761150.9991239
ENST00000423902ENST00000355717CHD7chr861655656+TCF7L2chr10114900942+0.0012323940.9987676
ENST00000423902ENST00000538897CHD7chr861655656+TCF7L2chr10114900942+0.0011514240.99884856
ENST00000423902ENST00000349937CHD7chr861655656+TCF7L2chr10114900942+0.018043310.9819567
ENST00000423902ENST00000369397CHD7chr861655656+TCF7L2chr10114900942+0.0009793660.9990206
ENST00000423902ENST00000352065CHD7chr861655656+TCF7L2chr10114900942+0.009965870.99003416
ENST00000423902ENST00000369395CHD7chr861655656+TCF7L2chr10114900942+0.0176417770.98235816
ENST00000524602ENST00000534894CHD7chr861655656+TCF7L2chr10114900942+0.0095500030.99044997
ENST00000524602ENST00000536810CHD7chr861655656+TCF7L2chr10114900942+0.0005720460.999428
ENST00000524602ENST00000545257CHD7chr861655656+TCF7L2chr10114900942+0.0005298730.9994702
ENST00000524602ENST00000355995CHD7chr861655656+TCF7L2chr10114900942+0.0005386330.99946135
ENST00000524602ENST00000543371CHD7chr861655656+TCF7L2chr10114900942+0.0005789630.999421
ENST00000524602ENST00000355717CHD7chr861655656+TCF7L2chr10114900942+0.0010910780.9989089
ENST00000524602ENST00000538897CHD7chr861655656+TCF7L2chr10114900942+0.0010151150.9989849
ENST00000524602ENST00000349937CHD7chr861655656+TCF7L2chr10114900942+0.0141093340.9858906
ENST00000524602ENST00000369397CHD7chr861655656+TCF7L2chr10114900942+0.0005386330.99946135
ENST00000524602ENST00000352065CHD7chr861655656+TCF7L2chr10114900942+0.010045320.9899547
ENST00000524602ENST00000369395CHD7chr861655656+TCF7L2chr10114900942+0.0139146170.9860854
ENST00000525508ENST00000534894CHD7chr861655656+TCF7L2chr10114900942+0.0090094810.9909905
ENST00000525508ENST00000536810CHD7chr861655656+TCF7L2chr10114900942+0.0005434310.9994566
ENST00000525508ENST00000545257CHD7chr861655656+TCF7L2chr10114900942+0.0005023270.99949765
ENST00000525508ENST00000355995CHD7chr861655656+TCF7L2chr10114900942+0.0005103280.99948967
ENST00000525508ENST00000543371CHD7chr861655656+TCF7L2chr10114900942+0.0005496080.9994504
ENST00000525508ENST00000355717CHD7chr861655656+TCF7L2chr10114900942+0.001033370.9989667
ENST00000525508ENST00000538897CHD7chr861655656+TCF7L2chr10114900942+0.0009604640.9990395
ENST00000525508ENST00000349937CHD7chr861655656+TCF7L2chr10114900942+0.0128631970.98713684
ENST00000525508ENST00000369397CHD7chr861655656+TCF7L2chr10114900942+0.0005103280.99948967
ENST00000525508ENST00000352065CHD7chr861655656+TCF7L2chr10114900942+0.0095107370.99048924
ENST00000525508ENST00000369395CHD7chr861655656+TCF7L2chr10114900942+0.0127282550.9872717

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

Top

Fusion Protein Breakpoint Sequences for CHD7-TCF7L2

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
CHD7chr861655656TCF7L2chr101149009421665554PSPQNTPQKVPVHQSNKVPVVQHPHH
CHD7chr861655656TCF7L2chr101149009421733565PSPQNTPQKVPVHQSNKVPVVQHPHH
CHD7chr861655656TCF7L2chr101149009422144565PSPQNTPQKVPVHQSNKVPVVQHPHH
CHD7chr861655656TCF7L2chr101149009431665554PSPQNTPQKVPVHQSNKVPVVQHPHH
CHD7chr861655656TCF7L2chr101149009431733565PSPQNTPQKVPVHQSNKVPVVQHPHH
CHD7chr861655656TCF7L2chr101149009432144565PSPQNTPQKVPVHQSNKVPVVQHPHH

Top

Potential FusionNeoAntigen Information of CHD7-TCF7L2 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
CHD7-TCF7L2_61655656_114900942.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
CHD7-TCF7L2chr861655656chr101149009422144HLA-A30:08KVPVHQSNK0.99380.6546817
CHD7-TCF7L2chr861655656chr101149009422144HLA-B39:24HQSNKVPVV0.99040.72741221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B14:01HQSNKVPVV0.9890.88381221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B14:02HQSNKVPVV0.9890.88381221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B39:06VHQSNKVPV0.98850.67881120
CHD7-TCF7L2chr861655656chr101149009422144HLA-B48:01HQSNKVPVV0.98810.69811221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B39:06HQSNKVPVV0.98410.88621221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B39:01VHQSNKVPV0.97930.71791120
CHD7-TCF7L2chr861655656chr101149009422144HLA-B38:02VHQSNKVPV0.96450.81661120
CHD7-TCF7L2chr861655656chr101149009422144HLA-B38:01VHQSNKVPV0.96350.80351120
CHD7-TCF7L2chr861655656chr101149009422144HLA-B08:09HQSNKVPVV0.92110.59331221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B39:01HQSNKVPVV0.91770.88171221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B13:02HQSNKVPVV0.91020.87961221
CHD7-TCF7L2chr861655656chr101149009422144HLA-A02:21HQSNKVPVV0.90130.61041221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B39:13HQSNKVPVV0.84220.91221221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B35:04VPVHQSNKV0.77530.6976918
CHD7-TCF7L2chr861655656chr101149009422144HLA-B35:02VPVHQSNKV0.77530.6976918
CHD7-TCF7L2chr861655656chr101149009422144HLA-B35:03VPVHQSNKV0.74980.6946918
CHD7-TCF7L2chr861655656chr101149009422144HLA-B13:01HQSNKVPVV0.67730.96061221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B15:37VHQSNKVPV0.50040.52631120
CHD7-TCF7L2chr861655656chr101149009422144HLA-B52:01HQSNKVPVV0.15560.97291221
CHD7-TCF7L2chr861655656chr101149009422144HLA-C06:03HQSNKVPVV0.99040.99091221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B39:09VHQSNKVPV0.97790.63931120
CHD7-TCF7L2chr861655656chr101149009422144HLA-B39:12HQSNKVPVV0.96330.88011221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B39:05VHQSNKVPV0.95640.70761120
CHD7-TCF7L2chr861655656chr101149009422144HLA-B39:09HQSNKVPVV0.91990.83061221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B39:08HQSNKVPVV0.85440.81651221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B15:04HQSNKVPVV0.80890.87111221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B39:05HQSNKVPVV0.80490.87851221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B35:12VPVHQSNKV0.77530.6976918
CHD7-TCF7L2chr861655656chr101149009422144HLA-B48:03HQSNKVPVV0.77010.61061221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B14:03HQSNKVPVV0.73040.82211221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B51:07HQSNKVPVV0.1350.84191221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B39:10VPVHQSNKV0.06610.6807918
CHD7-TCF7L2chr861655656chr101149009422144HLA-A30:01KVPVHQSNK0.99420.7912817
CHD7-TCF7L2chr861655656chr101149009422144HLA-A02:03HQSNKVPVV0.980.52491221
CHD7-TCF7L2chr861655656chr101149009422144HLA-C06:08HQSNKVPVV0.96690.98941221
CHD7-TCF7L2chr861655656chr101149009422144HLA-C06:17HQSNKVPVV0.96580.99021221
CHD7-TCF7L2chr861655656chr101149009422144HLA-C06:02HQSNKVPVV0.96580.99021221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B38:05VHQSNKVPV0.96350.80351120
CHD7-TCF7L2chr861655656chr101149009422144HLA-B15:73HQSNKVPVV0.96110.95251221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B39:02HQSNKVPVV0.94170.9061221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B39:31HQSNKVPVV0.93050.88021221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B15:30HQSNKVPVV0.90810.8871221
CHD7-TCF7L2chr861655656chr101149009422144HLA-A02:14HQSNKVPVV0.90370.53331221
CHD7-TCF7L2chr861655656chr101149009422144HLA-A02:06HQSNKVPVV0.90130.61041221
CHD7-TCF7L2chr861655656chr101149009422144HLA-C07:04HQSNKVPVV0.82160.97021221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B39:11HQSNKVPVV0.81230.74491221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B35:09VPVHQSNKV0.77530.6976918
CHD7-TCF7L2chr861655656chr101149009422144HLA-B15:09VHQSNKVPV0.77460.66231120
CHD7-TCF7L2chr861655656chr101149009422144HLA-B40:12HQSNKVPVV0.77010.61061221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B40:49HQSNKVPVV0.62130.54511221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B40:21HQSNKVPVV0.61670.65291221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B15:09HQSNKVPVV0.59240.86831221
CHD7-TCF7L2chr861655656chr101149009422144HLA-B39:11VHQSNKVPV0.30780.59471120

Top

Potential FusionNeoAntigen Information of CHD7-TCF7L2 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
CHD7-TCF7L2_61655656_114900942.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
CHD7-TCF7L2chr861655656chr101149009422144DRB1-0324KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-0324QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1113KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1113QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1117KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1117QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1117PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1117VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1148KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1152KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1152QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1152PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1152VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1189KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1189QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1189PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1308KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1331KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1331QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1331PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1332KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1332QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1336KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1343KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1343QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1348KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1348QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1354KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1354QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1370KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1372KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1376KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1376QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1377KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1377QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1384KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1396KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1401KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1401QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1401PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1401VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1401TPQKVPVHQSNKVPV520
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1404KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1404QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1404PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1404VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1405KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1405QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1405PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1405VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1407KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1407QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1407PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1407VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1408KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1408QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1408PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1408VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1411KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1411QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1411PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1411VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1414KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1414QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1416KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1416QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1416PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1418KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1418QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1418PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1418VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1421KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1423KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1423QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1423PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1423VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1424KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1426KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1426QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1426PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1426VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1426TPQKVPVHQSNKVPV520
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1428KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1428QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1428PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1428VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1429KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1431KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1431QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1431PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1432KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1432QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1432PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1433KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1433QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1434KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1434QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1435KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1435QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1435PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1435VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1436KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1436QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1437KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1438KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1438QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1438PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1438VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1438TPQKVPVHQSNKVPV520
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1439KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1439QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1439PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1439VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1442KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1442QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1443KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1443QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1443PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1443VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1444KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1444QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1445KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1445QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1445PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1445VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1448KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1449KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1449QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1450KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1450QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1450PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1450VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1451KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1454KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1454QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1454PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1454VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1454TPQKVPVHQSNKVPV520
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1455KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1455QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1455PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1456KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1456QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1456PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1456VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1458KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1458QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1458PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1458VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1458TPQKVPVHQSNKVPV520
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1459KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1459QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1459PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1459VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1460KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1460QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1460PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1460VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1460TPQKVPVHQSNKVPV520
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1461KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1461QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1461PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1461VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1462KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1462QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1462PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1462VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1462TPQKVPVHQSNKVPV520
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1464KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1464QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1464PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1464VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1465KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1465QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1468KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1468QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1468PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1470KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1470QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1470PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1470VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1470TPQKVPVHQSNKVPV520
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1471KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1471QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1471PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1471VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1472KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1472QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1472PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1472VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1473KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1473QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1474KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1474QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1475KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1475QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1475PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1475VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1475TPQKVPVHQSNKVPV520
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1480KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1481KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1481QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1482KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1482QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1482PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1482VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1482TPQKVPVHQSNKVPV520
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1486KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1486QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1486PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1486VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1486TPQKVPVHQSNKVPV520
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1487KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1487QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1487PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1487VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1487TPQKVPVHQSNKVPV520
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1488KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1488QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1488PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1488VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1488TPQKVPVHQSNKVPV520
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1490KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1490QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1490PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1490VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1490TPQKVPVHQSNKVPV520
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1491KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1491QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1491PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1491VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1493KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1493QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1493PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1495KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1495QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1495PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1495VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1496KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1496QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1496PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1496VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1497KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1497QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1497PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1497VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1497TPQKVPVHQSNKVPV520
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1499KVPVHQSNKVPVVQH823
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1499QKVPVHQSNKVPVVQ722
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1499PQKVPVHQSNKVPVV621
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1499VPVHQSNKVPVVQHP924
CHD7-TCF7L2chr861655656chr101149009422144DRB1-1499TPQKVPVHQSNKVPV520

Top

Fusion breakpoint peptide structures of CHD7-TCF7L2

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
6920PQKVPVHQSNKVPVCHD7TCF7L2chr861655656chr101149009422144

Top

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of CHD7-TCF7L2

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN6920PQKVPVHQSNKVPV-7.15543-7.26883
HLA-B14:023BVN6920PQKVPVHQSNKVPV-4.77435-5.80965
HLA-B52:013W396920PQKVPVHQSNKVPV-6.80875-6.92215
HLA-B52:013W396920PQKVPVHQSNKVPV-4.20386-5.23916
HLA-A11:014UQ26920PQKVPVHQSNKVPV-7.5194-8.5547
HLA-A11:014UQ26920PQKVPVHQSNKVPV-6.9601-7.0735
HLA-A24:025HGA6920PQKVPVHQSNKVPV-7.52403-7.63743
HLA-A24:025HGA6920PQKVPVHQSNKVPV-5.82433-6.85963
HLA-B27:056PYJ6920PQKVPVHQSNKVPV-3.28285-4.31815
HLA-B44:053DX86920PQKVPVHQSNKVPV-5.91172-6.94702
HLA-B44:053DX86920PQKVPVHQSNKVPV-4.24346-4.35686

Top

Vaccine Design for the FusionNeoAntigens of CHD7-TCF7L2

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
CHD7-TCF7L2chr861655656chr101149009421120VHQSNKVPVCATCAGTCTAACAAAGTGCCAGTGGTG
CHD7-TCF7L2chr861655656chr101149009421221HQSNKVPVVCAGTCTAACAAAGTGCCAGTGGTGCAG
CHD7-TCF7L2chr861655656chr10114900942817KVPVHQSNKGTGCCTGTGCATCAGTCTAACAAAGTG
CHD7-TCF7L2chr861655656chr10114900942918VPVHQSNKVCCTGTGCATCAGTCTAACAAAGTGCCA

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
CHD7-TCF7L2chr861655656chr10114900942520TPQKVPVHQSNKVPVCCGCAGAAAGTGCCTGTGCATCAGTCTAACAAAGTGCCAGTGGTG
CHD7-TCF7L2chr861655656chr10114900942621PQKVPVHQSNKVPVVCAGAAAGTGCCTGTGCATCAGTCTAACAAAGTGCCAGTGGTGCAG
CHD7-TCF7L2chr861655656chr10114900942722QKVPVHQSNKVPVVQAAAGTGCCTGTGCATCAGTCTAACAAAGTGCCAGTGGTGCAGCAC
CHD7-TCF7L2chr861655656chr10114900942823KVPVHQSNKVPVVQHGTGCCTGTGCATCAGTCTAACAAAGTGCCAGTGGTGCAGCACCCT
CHD7-TCF7L2chr861655656chr10114900942924VPVHQSNKVPVVQHPCCTGTGCATCAGTCTAACAAAGTGCCAGTGGTGCAGCACCCTCAC

Top

Information of the samples that have these potential fusion neoantigens of CHD7-TCF7L2

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
COADCHD7-TCF7L2chr861655656ENST00000423902chr10114900942ENST00000349937TCGA-F4-6807

Top

Potential target of CAR-T therapy development for CHD7-TCF7L2

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

Top

Related Drugs to CHD7-TCF7L2

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to CHD7-TCF7L2

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTCF7L2C0036341Schizophrenia4PSYGENET
TgeneTCF7L2C0011860Diabetes Mellitus, Non-Insulin-Dependent3CTD_human
TgeneTCF7L2C0009402Colorectal Carcinoma2CTD_human;UNIPROT
TgeneTCF7L2C0009404Colorectal Neoplasms2CTD_human
TgeneTCF7L2C0001418Adenocarcinoma1CTD_human
TgeneTCF7L2C0005586Bipolar Disorder1PSYGENET
TgeneTCF7L2C0007102Malignant tumor of colon1CTD_human
TgeneTCF7L2C0007193Cardiomyopathy, Dilated1CTD_human
TgeneTCF7L2C0009375Colonic Neoplasms1CTD_human
TgeneTCF7L2C0010068Coronary heart disease1CTD_human
TgeneTCF7L2C0020507Hyperplasia1CTD_human
TgeneTCF7L2C0036337Schizoaffective Disorder1PSYGENET
TgeneTCF7L2C0087031Juvenile-Onset Still Disease1CTD_human
TgeneTCF7L2C0151744Myocardial Ischemia1CTD_human
TgeneTCF7L2C0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneTCF7L2C0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneTCF7L2C0205643Carcinoma, Cribriform1CTD_human
TgeneTCF7L2C0205644Carcinoma, Granular Cell1CTD_human
TgeneTCF7L2C0205645Adenocarcinoma, Tubular1CTD_human
TgeneTCF7L2C0600519Ventricular Remodeling1CTD_human
TgeneTCF7L2C0600520Left Ventricle Remodeling1CTD_human
TgeneTCF7L2C1449563Cardiomyopathy, Familial Idiopathic1CTD_human
TgeneTCF7L2C1535926Neurodevelopmental Disorders1CTD_human
TgeneTCF7L2C2931456Prostate cancer, familial1CTD_human
TgeneTCF7L2C3495559Juvenile arthritis1CTD_human
TgeneTCF7L2C3714758Juvenile psoriatic arthritis1CTD_human
TgeneTCF7L2C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneTCF7L2C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneTCF7L2C4722327PROSTATE CANCER, HEREDITARY, 11CTD_human