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Fusion Protein:CTPS1-NFYC

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CTPS1-NFYC
	FusionPDB ID: 20412
	FusionGDB2.0 ID: 20424
		Hgene	Tgene
	Gene symbol	CTPS1	NFYC
	Gene ID	1503	4802
	Gene name	CTP synthase 1	nuclear transcription factor Y subunit gamma
	Synonyms	CTPS\|GATD5\|IMD24	CBF-C\|CBFC\|H1TF2A\|HAP5\|HSM\|NF-YC
	Cytomap	1p34.2	1p34.2
	Type of gene	protein-coding	protein-coding
	Description	CTP synthase 1CTP synthetase 1UTP--ammonia ligase 1cytidine 5'-triphosphate synthetasecytidine 5-prime triphosphate synthetase	nuclear transcription factor Y subunit gammaCAAT box DNA-binding protein subunit CCCAAT binding factor subunit CCCAAT transcription binding factor subunit gammahistone H1 transcription factor large subunit 2Anuclear transcription factor Y subunit Cn
	Modification date	20200313	20200313
	UniProtAcc	P17812 Main function of 5'-partner protein: FUNCTION: This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity. {ECO:0000269\|PubMed:16179339, ECO:0000269\|PubMed:24870241}.	Q13952 Main function of 5'-partner protein: FUNCTION: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000372616, ENST00000372621, ENST00000541520, ENST00000543104, ENST00000475060,	ENST00000308733, ENST00000372651, ENST00000372652, ENST00000372653, ENST00000372654, ENST00000425457, ENST00000427410, ENST00000440226, ENST00000447388, ENST00000456393, ENST00000483091,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 8 X 6=336	16 X 10 X 7=1120
	# samples	9	18
	** MAII score	log2(9/336*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/1120*10)=-2.63742992061529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: CTPS1 [Title/Abstract] AND NFYC [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: CTPS1 [Title/Abstract] AND NFYC [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CTPS1(41457517)-NFYC(41204508), # samples:2 CTPS1(41474386)-NFYC(41213206), # samples:2 NFYC(41157539)-CTPS1(41466701), # samples:2
Anticipated loss of major functional domain due to fusion event.	CTPS1-NFYC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CTPS1-NFYC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CTPS1	GO:0006241	CTP biosynthetic process	16179339
Tgene	NFYC	GO:0006355	regulation of transcription, DNA-templated	15243141

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:41457517/chr1:41204508)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across CTPS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NFYC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000372621	CTPS1	chr1	41474386	+	ENST00000427410	NFYC	chr1	41213206	+	3044	1957	181	2745	854
ENST00000372621	CTPS1	chr1	41474386	+	ENST00000447388	NFYC	chr1	41213206	+	3635	1957	181	2859	892
ENST00000372621	CTPS1	chr1	41474386	+	ENST00000425457	NFYC	chr1	41213206	+	3228	1957	181	2916	911
ENST00000372621	CTPS1	chr1	41474386	+	ENST00000456393	NFYC	chr1	41213206	+	3630	1957	181	2856	891
ENST00000372621	CTPS1	chr1	41474386	+	ENST00000372654	NFYC	chr1	41213206	+	3134	1957	181	2859	892
ENST00000372621	CTPS1	chr1	41474386	+	ENST00000372653	NFYC	chr1	41213206	+	3036	1957	181	2757	858
ENST00000372621	CTPS1	chr1	41474386	+	ENST00000372652	NFYC	chr1	41213206	+	3947	1957	181	3171	996
ENST00000372621	CTPS1	chr1	41474386	+	ENST00000372651	NFYC	chr1	41213206	+	2972	1957	181	2859	892
ENST00000372621	CTPS1	chr1	41474386	+	ENST00000440226	NFYC	chr1	41213206	+	3125	1957	181	2859	892
ENST00000372621	CTPS1	chr1	41474386	+	ENST00000308733	NFYC	chr1	41213206	+	4004	1957	181	3228	1015
ENST00000541520	CTPS1	chr1	41474386	+	ENST00000427410	NFYC	chr1	41213206	+	2056	969	156	1757	533
ENST00000541520	CTPS1	chr1	41474386	+	ENST00000447388	NFYC	chr1	41213206	+	2647	969	156	1871	571
ENST00000541520	CTPS1	chr1	41474386	+	ENST00000425457	NFYC	chr1	41213206	+	2240	969	156	1928	590
ENST00000541520	CTPS1	chr1	41474386	+	ENST00000456393	NFYC	chr1	41213206	+	2642	969	156	1868	570
ENST00000541520	CTPS1	chr1	41474386	+	ENST00000372654	NFYC	chr1	41213206	+	2146	969	156	1871	571
ENST00000541520	CTPS1	chr1	41474386	+	ENST00000372653	NFYC	chr1	41213206	+	2048	969	156	1769	537
ENST00000541520	CTPS1	chr1	41474386	+	ENST00000372652	NFYC	chr1	41213206	+	2959	969	156	2183	675
ENST00000541520	CTPS1	chr1	41474386	+	ENST00000372651	NFYC	chr1	41213206	+	1984	969	156	1871	571
ENST00000541520	CTPS1	chr1	41474386	+	ENST00000440226	NFYC	chr1	41213206	+	2137	969	156	1871	571
ENST00000541520	CTPS1	chr1	41474386	+	ENST00000308733	NFYC	chr1	41213206	+	3016	969	156	2240	694
ENST00000372616	CTPS1	chr1	41474386	+	ENST00000427410	NFYC	chr1	41213206	+	2666	1579	130	2367	745
ENST00000372616	CTPS1	chr1	41474386	+	ENST00000447388	NFYC	chr1	41213206	+	3257	1579	130	2481	783
ENST00000372616	CTPS1	chr1	41474386	+	ENST00000425457	NFYC	chr1	41213206	+	2850	1579	130	2538	802
ENST00000372616	CTPS1	chr1	41474386	+	ENST00000456393	NFYC	chr1	41213206	+	3252	1579	130	2478	782
ENST00000372616	CTPS1	chr1	41474386	+	ENST00000372654	NFYC	chr1	41213206	+	2756	1579	130	2481	783
ENST00000372616	CTPS1	chr1	41474386	+	ENST00000372653	NFYC	chr1	41213206	+	2658	1579	130	2379	749
ENST00000372616	CTPS1	chr1	41474386	+	ENST00000372652	NFYC	chr1	41213206	+	3569	1579	130	2793	887
ENST00000372616	CTPS1	chr1	41474386	+	ENST00000372651	NFYC	chr1	41213206	+	2594	1579	130	2481	783
ENST00000372616	CTPS1	chr1	41474386	+	ENST00000440226	NFYC	chr1	41213206	+	2747	1579	130	2481	783
ENST00000372616	CTPS1	chr1	41474386	+	ENST00000308733	NFYC	chr1	41213206	+	3626	1579	130	2850	906
ENST00000372621	CTPS1	chr1	41474386	+	ENST00000427410	NFYC	chr1	41213205	+	3044	1957	181	2745	854
ENST00000372621	CTPS1	chr1	41474386	+	ENST00000447388	NFYC	chr1	41213205	+	3635	1957	181	2859	892
ENST00000372621	CTPS1	chr1	41474386	+	ENST00000425457	NFYC	chr1	41213205	+	3228	1957	181	2916	911
ENST00000372621	CTPS1	chr1	41474386	+	ENST00000456393	NFYC	chr1	41213205	+	3630	1957	181	2856	891
ENST00000372621	CTPS1	chr1	41474386	+	ENST00000372654	NFYC	chr1	41213205	+	3134	1957	181	2859	892
ENST00000372621	CTPS1	chr1	41474386	+	ENST00000372653	NFYC	chr1	41213205	+	3036	1957	181	2757	858
ENST00000372621	CTPS1	chr1	41474386	+	ENST00000372652	NFYC	chr1	41213205	+	3947	1957	181	3171	996
ENST00000372621	CTPS1	chr1	41474386	+	ENST00000372651	NFYC	chr1	41213205	+	2972	1957	181	2859	892
ENST00000372621	CTPS1	chr1	41474386	+	ENST00000440226	NFYC	chr1	41213205	+	3125	1957	181	2859	892
ENST00000372621	CTPS1	chr1	41474386	+	ENST00000308733	NFYC	chr1	41213205	+	4004	1957	181	3228	1015
ENST00000541520	CTPS1	chr1	41474386	+	ENST00000427410	NFYC	chr1	41213205	+	2056	969	156	1757	533
ENST00000541520	CTPS1	chr1	41474386	+	ENST00000447388	NFYC	chr1	41213205	+	2647	969	156	1871	571
ENST00000541520	CTPS1	chr1	41474386	+	ENST00000425457	NFYC	chr1	41213205	+	2240	969	156	1928	590
ENST00000541520	CTPS1	chr1	41474386	+	ENST00000456393	NFYC	chr1	41213205	+	2642	969	156	1868	570
ENST00000541520	CTPS1	chr1	41474386	+	ENST00000372654	NFYC	chr1	41213205	+	2146	969	156	1871	571
ENST00000541520	CTPS1	chr1	41474386	+	ENST00000372653	NFYC	chr1	41213205	+	2048	969	156	1769	537
ENST00000541520	CTPS1	chr1	41474386	+	ENST00000372652	NFYC	chr1	41213205	+	2959	969	156	2183	675
ENST00000541520	CTPS1	chr1	41474386	+	ENST00000372651	NFYC	chr1	41213205	+	1984	969	156	1871	571
ENST00000541520	CTPS1	chr1	41474386	+	ENST00000440226	NFYC	chr1	41213205	+	2137	969	156	1871	571
ENST00000541520	CTPS1	chr1	41474386	+	ENST00000308733	NFYC	chr1	41213205	+	3016	969	156	2240	694
ENST00000372616	CTPS1	chr1	41474386	+	ENST00000427410	NFYC	chr1	41213205	+	2666	1579	130	2367	745
ENST00000372616	CTPS1	chr1	41474386	+	ENST00000447388	NFYC	chr1	41213205	+	3257	1579	130	2481	783
ENST00000372616	CTPS1	chr1	41474386	+	ENST00000425457	NFYC	chr1	41213205	+	2850	1579	130	2538	802
ENST00000372616	CTPS1	chr1	41474386	+	ENST00000456393	NFYC	chr1	41213205	+	3252	1579	130	2478	782
ENST00000372616	CTPS1	chr1	41474386	+	ENST00000372654	NFYC	chr1	41213205	+	2756	1579	130	2481	783
ENST00000372616	CTPS1	chr1	41474386	+	ENST00000372653	NFYC	chr1	41213205	+	2658	1579	130	2379	749
ENST00000372616	CTPS1	chr1	41474386	+	ENST00000372652	NFYC	chr1	41213205	+	3569	1579	130	2793	887
ENST00000372616	CTPS1	chr1	41474386	+	ENST00000372651	NFYC	chr1	41213205	+	2594	1579	130	2481	783
ENST00000372616	CTPS1	chr1	41474386	+	ENST00000440226	NFYC	chr1	41213205	+	2747	1579	130	2481	783
ENST00000372616	CTPS1	chr1	41474386	+	ENST00000308733	NFYC	chr1	41213205	+	3626	1579	130	2850	906
ENST00000372621	CTPS1	chr1	41471766	+	ENST00000427410	NFYC	chr1	41213206	+	2891	1804	181	2592	803
ENST00000372621	CTPS1	chr1	41471766	+	ENST00000447388	NFYC	chr1	41213206	+	3482	1804	181	2706	841
ENST00000372621	CTPS1	chr1	41471766	+	ENST00000425457	NFYC	chr1	41213206	+	3075	1804	181	2763	860
ENST00000372621	CTPS1	chr1	41471766	+	ENST00000456393	NFYC	chr1	41213206	+	3477	1804	181	2703	840
ENST00000372621	CTPS1	chr1	41471766	+	ENST00000372654	NFYC	chr1	41213206	+	2981	1804	181	2706	841
ENST00000372621	CTPS1	chr1	41471766	+	ENST00000372653	NFYC	chr1	41213206	+	2883	1804	181	2604	807
ENST00000372621	CTPS1	chr1	41471766	+	ENST00000372652	NFYC	chr1	41213206	+	3794	1804	181	3018	945
ENST00000372621	CTPS1	chr1	41471766	+	ENST00000372651	NFYC	chr1	41213206	+	2819	1804	181	2706	841
ENST00000372621	CTPS1	chr1	41471766	+	ENST00000440226	NFYC	chr1	41213206	+	2972	1804	181	2706	841
ENST00000372621	CTPS1	chr1	41471766	+	ENST00000308733	NFYC	chr1	41213206	+	3851	1804	181	3075	964
ENST00000541520	CTPS1	chr1	41471766	+	ENST00000427410	NFYC	chr1	41213206	+	1903	816	156	1604	482
ENST00000541520	CTPS1	chr1	41471766	+	ENST00000447388	NFYC	chr1	41213206	+	2494	816	156	1718	520
ENST00000541520	CTPS1	chr1	41471766	+	ENST00000425457	NFYC	chr1	41213206	+	2087	816	156	1775	539
ENST00000541520	CTPS1	chr1	41471766	+	ENST00000456393	NFYC	chr1	41213206	+	2489	816	156	1715	519
ENST00000541520	CTPS1	chr1	41471766	+	ENST00000372654	NFYC	chr1	41213206	+	1993	816	156	1718	520
ENST00000541520	CTPS1	chr1	41471766	+	ENST00000372653	NFYC	chr1	41213206	+	1895	816	156	1616	486
ENST00000541520	CTPS1	chr1	41471766	+	ENST00000372652	NFYC	chr1	41213206	+	2806	816	156	2030	624
ENST00000541520	CTPS1	chr1	41471766	+	ENST00000372651	NFYC	chr1	41213206	+	1831	816	156	1718	520
ENST00000541520	CTPS1	chr1	41471766	+	ENST00000440226	NFYC	chr1	41213206	+	1984	816	156	1718	520
ENST00000541520	CTPS1	chr1	41471766	+	ENST00000308733	NFYC	chr1	41213206	+	2863	816	156	2087	643
ENST00000372616	CTPS1	chr1	41471766	+	ENST00000427410	NFYC	chr1	41213206	+	2513	1426	130	2214	694
ENST00000372616	CTPS1	chr1	41471766	+	ENST00000447388	NFYC	chr1	41213206	+	3104	1426	130	2328	732
ENST00000372616	CTPS1	chr1	41471766	+	ENST00000425457	NFYC	chr1	41213206	+	2697	1426	130	2385	751
ENST00000372616	CTPS1	chr1	41471766	+	ENST00000456393	NFYC	chr1	41213206	+	3099	1426	130	2325	731
ENST00000372616	CTPS1	chr1	41471766	+	ENST00000372654	NFYC	chr1	41213206	+	2603	1426	130	2328	732
ENST00000372616	CTPS1	chr1	41471766	+	ENST00000372653	NFYC	chr1	41213206	+	2505	1426	130	2226	698
ENST00000372616	CTPS1	chr1	41471766	+	ENST00000372652	NFYC	chr1	41213206	+	3416	1426	130	2640	836
ENST00000372616	CTPS1	chr1	41471766	+	ENST00000372651	NFYC	chr1	41213206	+	2441	1426	130	2328	732
ENST00000372616	CTPS1	chr1	41471766	+	ENST00000440226	NFYC	chr1	41213206	+	2594	1426	130	2328	732
ENST00000372616	CTPS1	chr1	41471766	+	ENST00000308733	NFYC	chr1	41213206	+	3473	1426	130	2697	855

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000372621	ENST00000427410	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.005039133	0.9949609
ENST00000372621	ENST00000447388	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.003070069	0.99692994
ENST00000372621	ENST00000425457	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.004602046	0.995398
ENST00000372621	ENST00000456393	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.002968655	0.99703133
ENST00000372621	ENST00000372654	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.00553423	0.99446577
ENST00000372621	ENST00000372653	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.004768243	0.9952317
ENST00000372621	ENST00000372652	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.002501316	0.9974987
ENST00000372621	ENST00000372651	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.006696574	0.99330336
ENST00000372621	ENST00000440226	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.005936953	0.9940631
ENST00000372621	ENST00000308733	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.002224599	0.9977754
ENST00000541520	ENST00000427410	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.00707387	0.9929261
ENST00000541520	ENST00000447388	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.00583607	0.99416393
ENST00000541520	ENST00000425457	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.01356906	0.98643094
ENST00000541520	ENST00000456393	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.005750034	0.99424994
ENST00000541520	ENST00000372654	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.011261751	0.9887383
ENST00000541520	ENST00000372653	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.008106308	0.9918937
ENST00000541520	ENST00000372652	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.013219488	0.98678046
ENST00000541520	ENST00000372651	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.012085928	0.98791414
ENST00000541520	ENST00000440226	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.011150005	0.98884994
ENST00000541520	ENST00000308733	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.013357418	0.9866426
ENST00000372616	ENST00000427410	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.003499979	0.9965
ENST00000372616	ENST00000447388	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.002272349	0.9977277
ENST00000372616	ENST00000425457	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.003296871	0.9967031
ENST00000372616	ENST00000456393	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.002194565	0.9978054
ENST00000372616	ENST00000372654	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.003861538	0.9961384
ENST00000372616	ENST00000372653	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.003216201	0.99678373
ENST00000372616	ENST00000372652	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.00190847	0.9980915
ENST00000372616	ENST00000372651	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.0048926	0.9951074
ENST00000372616	ENST00000440226	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.00417583	0.9958242
ENST00000372616	ENST00000308733	CTPS1	chr1	41474386	+	NFYC	chr1	41213206	+	0.001683204	0.99831676
ENST00000372621	ENST00000427410	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.005039133	0.9949609
ENST00000372621	ENST00000447388	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.003070069	0.99692994
ENST00000372621	ENST00000425457	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.004602046	0.995398
ENST00000372621	ENST00000456393	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.002968655	0.99703133
ENST00000372621	ENST00000372654	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.00553423	0.99446577
ENST00000372621	ENST00000372653	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.004768243	0.9952317
ENST00000372621	ENST00000372652	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.002501316	0.9974987
ENST00000372621	ENST00000372651	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.006696574	0.99330336
ENST00000372621	ENST00000440226	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.005936953	0.9940631
ENST00000372621	ENST00000308733	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.002224599	0.9977754
ENST00000541520	ENST00000427410	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.00707387	0.9929261
ENST00000541520	ENST00000447388	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.00583607	0.99416393
ENST00000541520	ENST00000425457	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.01356906	0.98643094
ENST00000541520	ENST00000456393	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.005750034	0.99424994
ENST00000541520	ENST00000372654	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.011261751	0.9887383
ENST00000541520	ENST00000372653	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.008106308	0.9918937
ENST00000541520	ENST00000372652	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.013219488	0.98678046
ENST00000541520	ENST00000372651	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.012085928	0.98791414
ENST00000541520	ENST00000440226	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.011150005	0.98884994
ENST00000541520	ENST00000308733	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.013357418	0.9866426
ENST00000372616	ENST00000427410	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.003499979	0.9965
ENST00000372616	ENST00000447388	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.002272349	0.9977277
ENST00000372616	ENST00000425457	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.003296871	0.9967031
ENST00000372616	ENST00000456393	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.002194565	0.9978054
ENST00000372616	ENST00000372654	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.003861538	0.9961384
ENST00000372616	ENST00000372653	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.003216201	0.99678373
ENST00000372616	ENST00000372652	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.00190847	0.9980915
ENST00000372616	ENST00000372651	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.0048926	0.9951074
ENST00000372616	ENST00000440226	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.00417583	0.9958242
ENST00000372616	ENST00000308733	CTPS1	chr1	41474386	+	NFYC	chr1	41213205	+	0.001683204	0.99831676
ENST00000372621	ENST00000427410	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.003437802	0.9965622
ENST00000372621	ENST00000447388	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.002796997	0.997203
ENST00000372621	ENST00000425457	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.004098292	0.99590176
ENST00000372621	ENST00000456393	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.002669255	0.9973308
ENST00000372621	ENST00000372654	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.004888871	0.99511117
ENST00000372621	ENST00000372653	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.003786575	0.9962134
ENST00000372621	ENST00000372652	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.002252982	0.997747
ENST00000372621	ENST00000372651	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.005914814	0.9940852
ENST00000372621	ENST00000440226	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.005204754	0.99479526
ENST00000372621	ENST00000308733	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.00232618	0.9976738
ENST00000541520	ENST00000427410	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.004400038	0.9956
ENST00000541520	ENST00000447388	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.003551221	0.99644876
ENST00000541520	ENST00000425457	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.007643718	0.9923563
ENST00000541520	ENST00000456393	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.003430186	0.99656975
ENST00000541520	ENST00000372654	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.006699305	0.9933007
ENST00000541520	ENST00000372653	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.004968724	0.99503124
ENST00000541520	ENST00000372652	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.007944943	0.99205506
ENST00000541520	ENST00000372651	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.007233305	0.99276674
ENST00000541520	ENST00000440226	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.006654829	0.99334514
ENST00000541520	ENST00000308733	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.009877598	0.9901224
ENST00000372616	ENST00000427410	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.002291109	0.9977089
ENST00000372616	ENST00000447388	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.001986687	0.99801326
ENST00000372616	ENST00000425457	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.002762664	0.9972373
ENST00000372616	ENST00000456393	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.001895433	0.9981046
ENST00000372616	ENST00000372654	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.003300925	0.99669904
ENST00000372616	ENST00000372653	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.002504783	0.9974953
ENST00000372616	ENST00000372652	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.001699699	0.9983004
ENST00000372616	ENST00000372651	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.00422081	0.99577916
ENST00000372616	ENST00000440226	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.003562133	0.9964379
ENST00000372616	ENST00000308733	CTPS1	chr1	41471766	+	NFYC	chr1	41213206	+	0.001748601	0.9982514

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for CTPS1-NFYC

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
CTPS1	chr1	41471766	NFYC	chr1	41213206	1426	432	NSTEFDPTTSHPVKDFRVQELPLARI
CTPS1	chr1	41471766	NFYC	chr1	41213206	1804	541	NSTEFDPTTSHPVKDFRVQELPLARI
CTPS1	chr1	41471766	NFYC	chr1	41213206	816	220	NSTEFDPTTSHPVKDFRVQELPLARI
CTPS1	chr1	41474386	NFYC	chr1	41213205	1579	481	GDADYLEERHRHRFEKDFRVQELPLA
CTPS1	chr1	41474386	NFYC	chr1	41213205	1957	590	GDADYLEERHRHRFEKDFRVQELPLA
CTPS1	chr1	41474386	NFYC	chr1	41213205	969	269	GDADYLEERHRHRFEKDFRVQELPLA
CTPS1	chr1	41474386	NFYC	chr1	41213206	1579	481	GDADYLEERHRHRFEKDFRVQELPLA
CTPS1	chr1	41474386	NFYC	chr1	41213206	1957	590	GDADYLEERHRHRFEKDFRVQELPLA
CTPS1	chr1	41474386	NFYC	chr1	41213206	969	269	GDADYLEERHRHRFEKDFRVQELPLA

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Potential FusionNeoAntigen Information of CTPS1-NFYC in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

CTPS1-NFYC_41471766_41213206.msa
CTPS1-NFYC_41474386_41213205.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B39:01	VKDFRVQEL	0.9954	0.8744	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B39:24	VKDFRVQEL	0.9954	0.5857	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B14:01	VKDFRVQEL	0.9954	0.8859	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B14:02	VKDFRVQEL	0.9954	0.8859	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B38:02	VKDFRVQEL	0.9904	0.9503	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B39:13	VKDFRVQEL	0.9798	0.9056	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B15:10	VKDFRVQEL	0.9134	0.6473	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B38:02	SHPVKDFRV	0.8341	0.7927	9	18
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B15:37	VKDFRVQEL	0.802	0.738	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B48:01	VKDFRVQEL	0.7573	0.5414	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B07:02	HPVKDFRVQEL	0.9996	0.6105	10	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B08:01	HPVKDFRVQEL	0.9953	0.5945	10	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B35:03	HPVKDFRVQEL	0.9818	0.8482	10	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B81:01	HPVKDFRVQEL	0.9587	0.5847	10	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B35:02	HPVKDFRVQEL	0.9356	0.9431	10	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B35:04	HPVKDFRVQEL	0.9356	0.9431	10	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B82:01	HPVKDFRVQEL	0.8666	0.5267	10	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-C08:15	VKDFRVQEL	0.9994	0.9756	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-C04:10	VKDFRVQEL	0.9989	0.9082	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-C04:07	VKDFRVQEL	0.9983	0.9183	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B39:09	VKDFRVQEL	0.9956	0.6844	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B39:12	VKDFRVQEL	0.9943	0.8802	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-C07:95	VKDFRVQEL	0.9789	0.7245	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B39:05	VKDFRVQEL	0.9742	0.859	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-C07:29	VKDFRVQEL	0.9648	0.9413	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-C07:13	VKDFRVQEL	0.9561	0.9362	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-C07:19	VKDFRVQEL	0.8837	0.7892	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-C08:13	VKDFRVQEL	0.846	0.9841	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-C08:04	VKDFRVQEL	0.846	0.9841	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B14:03	VKDFRVQEL	0.7821	0.8174	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B39:08	VKDFRVQEL	0.7794	0.8146	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-C04:14	VKDFRVQEL	0.5542	0.9308	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-C12:16	VKDFRVQEL	0.1153	0.9703	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B07:04	HPVKDFRVQEL	0.9963	0.5744	10	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B42:02	HPVKDFRVQEL	0.9953	0.605	10	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B42:01	HPVKDFRVQEL	0.995	0.6007	10	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B07:12	HPVKDFRVQEL	0.9892	0.7004	10	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B35:12	HPVKDFRVQEL	0.9356	0.9431	10	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B39:10	HPVKDFRVQEL	0.9038	0.9014	10	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-C08:02	VKDFRVQEL	0.9994	0.9756	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-C18:01	VKDFRVQEL	0.999	0.9343	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-C04:01	VKDFRVQEL	0.9983	0.9183	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B39:02	VKDFRVQEL	0.9958	0.9009	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B39:31	VKDFRVQEL	0.9953	0.8756	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B39:11	VKDFRVQEL	0.9276	0.7549	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-C06:06	VKDFRVQEL	0.9229	0.9905	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-C07:17	VKDFRVQEL	0.9162	0.9634	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-C03:67	VKDFRVQEL	0.8798	0.9872	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B15:09	VKDFRVQEL	0.8395	0.8124	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-C07:04	VKDFRVQEL	0.8226	0.9002	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-C04:04	VKDFRVQEL	0.794	0.9579	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B08:12	VKDFRVQEL	0.5146	0.5523	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-C16:02	TTSHPVKDF	0.0615	0.9888	7	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B07:13	VKDFRVQEL	0.0427	0.8526	12	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B07:22	HPVKDFRVQEL	0.9996	0.6105	10	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B08:18	HPVKDFRVQEL	0.9953	0.5945	10	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B55:04	HPVKDFRVQEL	0.9813	0.5756	10	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B35:13	HPVKDFRVQEL	0.9799	0.8558	10	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B35:22	HPVKDFRVQEL	0.9674	0.537	10	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B08:12	HPVKDFRVQEL	0.9609	0.7151	10	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B35:09	HPVKDFRVQEL	0.9356	0.9431	10	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B67:01	HPVKDFRVQEL	0.9309	0.7952	10	21
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	HLA-B82:02	HPVKDFRVQEL	0.8666	0.5267	10	21
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B18:01	EERHRHRF	0.9859	0.8954	6	14
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:05	HRFEKDFRV	0.9998	0.8999	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:02	HRFEKDFRV	0.9998	0.7549	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:04	HRFEKDFRV	0.9998	0.8271	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B14:01	HRFEKDFRV	0.9977	0.7623	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B14:02	HRFEKDFRV	0.9977	0.7623	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B39:06	HRFEKDFRV	0.9975	0.7995	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:02	HRHRFEKDF	0.9973	0.7254	9	18
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:04	HRHRFEKDF	0.9971	0.8296	9	18
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B39:01	HRFEKDFRV	0.9894	0.8688	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B38:01	HRFEKDFRV	0.9892	0.9376	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B38:02	HRFEKDFRV	0.9864	0.9481	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B18:01	LEERHRHRF	0.9735	0.8872	5	14
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B44:03	LEERHRHRF	0.8184	0.7996	5	14
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B15:37	HRFEKDFRV	0.1855	0.7138	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:05	RHRFEKDFRV	0.9868	0.7169	10	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:07	RHRFEKDFRV	0.9864	0.5303	10	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:04	RHRFEKDFRV	0.9855	0.7332	10	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:14	HRFEKDFRV	0.9998	0.866	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B73:01	HRFEKDFRV	0.9985	0.7738	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B39:12	HRFEKDFRV	0.9896	0.8715	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B39:09	HRFEKDFRV	0.9893	0.6732	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C07:05	HRFEKDFRV	0.9886	0.9751	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:03	HRFEKDFRV	0.9882	0.9096	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C07:27	HRFEKDFRV	0.9847	0.9625	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C07:95	HRFEKDFRV	0.9835	0.8392	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C07:95	HRHRFEKDF	0.9731	0.7024	9	18
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C07:13	HRFEKDFRV	0.973	0.9332	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C07:05	HRHRFEKDF	0.9697	0.948	9	18
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B39:05	HRFEKDFRV	0.9684	0.8531	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C07:29	HRFEKDFRV	0.9538	0.9382	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:03	HRHRFEKDF	0.8634	0.9372	9	18
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C07:46	HRFEKDFRV	0.854	0.9344	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C07:19	HRFEKDFRV	0.8489	0.8703	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C07:10	HRFEKDFRV	0.8362	0.9749	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C07:80	HRFEKDFRV	0.8324	0.9607	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C07:67	HRFEKDFRV	0.8324	0.9607	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C07:46	HRHRFEKDF	0.7628	0.8695	9	18
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B14:03	HRFEKDFRV	0.5347	0.7008	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C12:16	HRHRFEKDF	0.0078	0.941	9	18
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C12:16	HRFEKDFRV	0.0062	0.9309	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:14	RHRFEKDFRV	0.987	0.7245	10	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:03	RHRFEKDFRV	0.7663	0.7355	10	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B18:05	EERHRHRF	0.9859	0.8954	6	14
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B18:03	EERHRHRF	0.9841	0.8873	6	14
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:09	HRFEKDFRV	0.9998	0.8464	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:10	HRFEKDFRV	0.9998	0.8979	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:08	HRFEKDFRV	0.9998	0.8568	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:06	HRFEKDFRV	0.9997	0.8365	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:06	HRHRFEKDF	0.995	0.8338	9	18
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B39:31	HRFEKDFRV	0.9918	0.869	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B38:05	HRFEKDFRV	0.9892	0.9376	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C07:01	HRFEKDFRV	0.9855	0.8306	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C07:01	HRHRFEKDF	0.9847	0.6825	9	18
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C06:08	HRFEKDFRV	0.9764	0.9855	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B18:05	LEERHRHRF	0.9735	0.8872	5	14
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B18:08	LEERHRHRF	0.972	0.6975	5	14
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B18:03	LEERHRHRF	0.9485	0.8783	5	14
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C07:04	HRFEKDFRV	0.9066	0.9274	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C07:17	HRFEKDFRV	0.9041	0.9657	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C07:02	HRFEKDFRV	0.8324	0.9607	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B44:26	LEERHRHRF	0.8184	0.7996	5	14
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B44:07	LEERHRHRF	0.8184	0.7996	5	14
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B44:13	LEERHRHRF	0.8184	0.7996	5	14
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C07:22	HRFEKDFRV	0.6776	0.7652	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C07:22	HRHRFEKDF	0.6608	0.6504	9	18
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B18:11	LEERHRHRF	0.6052	0.7822	5	14
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B15:09	HRFEKDFRV	0.5092	0.6361	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C06:06	HRFEKDFRV	0.3205	0.9791	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C06:17	HRFEKDFRV	0.0807	0.9875	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C06:02	HRFEKDFRV	0.0807	0.9875	11	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B41:03	LEERHRHRF	0.069	0.5385	5	14
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C06:02	HRHRFEKDF	0.027	0.9842	9	18
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-C06:17	HRHRFEKDF	0.027	0.9842	9	18
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:06	RHRFEKDFRV	0.9906	0.7413	10	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:08	RHRFEKDFRV	0.9861	0.6693	10	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:10	RHRFEKDFRV	0.9856	0.8176	10	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B27:09	RHRFEKDFRV	0.9845	0.6876	10	20
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	HLA-B08:12	YLEERHRHRF	0.7676	0.559	4	14

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Potential FusionNeoAntigen Information of CTPS1-NFYC in HLA II

CTPS1-NFYC_41471766_41213206.msa
CTPS1-NFYC_41474386_41213205.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0103	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0103	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0109	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0113	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0113	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0115	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0117	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0117	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0121	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0121	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0469	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0469	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0469	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0482	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0482	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0701	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0701	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0701	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0701	EFDPTTSHPVKDFRV	3	18
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0703	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0703	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0703	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0703	EFDPTTSHPVKDFRV	3	18
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0704	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0704	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0704	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0705	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0705	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0705	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0705	EFDPTTSHPVKDFRV	3	18
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0706	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0706	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0706	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0706	EFDPTTSHPVKDFRV	3	18
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0707	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0707	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0707	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0707	EFDPTTSHPVKDFRV	3	18
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0708	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0708	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0708	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0708	EFDPTTSHPVKDFRV	3	18
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0709	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0709	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0709	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0709	EFDPTTSHPVKDFRV	3	18
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0711	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0711	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0711	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0711	EFDPTTSHPVKDFRV	3	18
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0712	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0712	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0712	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0712	EFDPTTSHPVKDFRV	3	18
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0713	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0713	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0713	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0713	EFDPTTSHPVKDFRV	3	18
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0714	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0714	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0714	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0714	EFDPTTSHPVKDFRV	3	18
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0715	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0715	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0715	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0715	EFDPTTSHPVKDFRV	3	18
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0716	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0716	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0716	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0716	EFDPTTSHPVKDFRV	3	18
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0717	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0717	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0717	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0717	EFDPTTSHPVKDFRV	3	18
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0719	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0719	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0719	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0719	EFDPTTSHPVKDFRV	3	18
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0807	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0807	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0819	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0819	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0819	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0825	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0825	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0825	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0834	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0834	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0834	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0901	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0901	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0901	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0902	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0902	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0902	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0903	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0903	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0903	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0904	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0904	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0904	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0905	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0905	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0905	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0907	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0907	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0907	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0908	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0908	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0908	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0909	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0909	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-0909	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-13100	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-13100	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1331	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1331	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1346	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1346	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1367	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1367	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1407	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1446	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1446	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1448	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1448	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1449	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1449	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1468	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1468	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1493	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1493	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1502	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1508	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1511	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1511	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1514	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1515	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1515	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1519	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1526	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1527	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1527	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1529	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1529	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1529	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1530	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1530	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1531	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1531	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1534	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1534	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1538	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1539	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1544	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1547	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1601	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1601	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1602	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1602	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1602	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1603	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1603	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1604	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1604	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1605	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1605	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1607	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1607	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1608	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1608	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1609	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1609	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1610	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1610	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1611	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1611	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1611	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1612	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1612	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1612	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1614	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1614	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1614	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1616	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1616	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB1-1616	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB3-0209	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB3-0209	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB3-0215	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB3-0215	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB3-0221	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB3-0221	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB4-0101	PVKDFRVQELPLARI	11	26
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB4-0101	HPVKDFRVQELPLAR	10	25
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB4-0103	PVKDFRVQELPLARI	11	26
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB4-0103	HPVKDFRVQELPLAR	10	25
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB4-0104	PVKDFRVQELPLARI	11	26
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB4-0104	HPVKDFRVQELPLAR	10	25
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB4-0106	PVKDFRVQELPLARI	11	26
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB4-0106	HPVKDFRVQELPLAR	10	25
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB4-0107	PVKDFRVQELPLARI	11	26
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB4-0107	HPVKDFRVQELPLAR	10	25
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB4-0108	PVKDFRVQELPLARI	11	26
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB4-0108	HPVKDFRVQELPLAR	10	25
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB5-0112	NSTEFDPTTSHPVKD	0	15
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB5-0112	STEFDPTTSHPVKDF	1	16
CTPS1-NFYC	chr1	41471766	chr1	41213206	1426	DRB5-0112	TEFDPTTSHPVKDFR	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-0305	HRHRFEKDFRVQELP	9	24
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-0305	RHRFEKDFRVQELPL	10	25
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-0305	RHRHRFEKDFRVQEL	8	23
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-0340	HRHRFEKDFRVQELP	9	24
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-0340	RHRFEKDFRVQELPL	10	25
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-0340	RHRHRFEKDFRVQEL	8	23
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-0840	HRHRFEKDFRVQELP	9	24
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-0840	RHRFEKDFRVQELPL	10	25
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-0840	RHRHRFEKDFRVQEL	8	23
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1102	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1102	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1116	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1116	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1121	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1121	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1136	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1136	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1153	HRHRFEKDFRVQELP	9	24
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1153	RHRFEKDFRVQELPL	10	25
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1155	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1165	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1165	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1168	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1170	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1170	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1179	HRHRFEKDFRVQELP	9	24
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1179	RHRFEKDFRVQELPL	10	25
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1186	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1186	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1301	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1301	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1303	HRHRFEKDFRVQELP	9	24
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1303	RHRFEKDFRVQELPL	10	25
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1303	RHRHRFEKDFRVQEL	8	23
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1304	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1304	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-13101	HRHRFEKDFRVQELP	9	24
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-13101	RHRFEKDFRVQELPL	10	25
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-13101	RHRHRFEKDFRVQEL	8	23
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-13101	HRFEKDFRVQELPLA	11	26
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1310	HRHRFEKDFRVQELP	9	24
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1310	RHRFEKDFRVQELPL	10	25
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1310	RHRHRFEKDFRVQEL	8	23
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1310	HRFEKDFRVQELPLA	11	26
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1312	HRHRFEKDFRVQELP	9	24
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1315	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1315	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1316	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1316	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1317	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1320	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1320	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1322	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1322	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1327	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1329	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1333	HRHRFEKDFRVQELP	9	24
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1333	RHRFEKDFRVQELPL	10	25
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1333	RHRHRFEKDFRVQEL	8	23
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1333	HRFEKDFRVQELPLA	11	26
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1335	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1335	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1337	HRHRFEKDFRVQELP	9	24
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1337	RHRFEKDFRVQELPL	10	25
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1338	HRHRFEKDFRVQELP	9	24
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1343	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1343	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1351	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1351	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1352	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1352	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1354	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1357	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1357	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1359	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1359	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1361	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1364	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1364	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1365	HRHRFEKDFRVQELP	9	24
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1366	HRHRFEKDFRVQELP	9	24
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1366	RHRFEKDFRVQELPL	10	25
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1366	RHRHRFEKDFRVQEL	8	23
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1368	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1368	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1369	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1369	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1371	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1375	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1378	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1378	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1379	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1379	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1380	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1380	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1383	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1383	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1387	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1387	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1388	HRHRFEKDFRVQELP	9	24
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1388	RHRFEKDFRVQELPL	10	25
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1388	RHRHRFEKDFRVQEL	8	23
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1390	HRHRFEKDFRVQELP	9	24
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1390	RHRFEKDFRVQELPL	10	25
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1390	RHRHRFEKDFRVQEL	8	23
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1391	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1391	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1392	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1392	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1393	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1393	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1395	HRHRFEKDFRVQELP	9	24
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1395	RHRFEKDFRVQELPL	10	25
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1395	RHRHRFEKDFRVQEL	8	23
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1398	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1398	DADYLEERHRHRFEK	1	16
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1413	HRHRFEKDFRVQELP	9	24
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1413	RHRFEKDFRVQELPL	10	25
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1416	ADYLEERHRHRFEKD	2	17
CTPS1-NFYC	chr1	41474386	chr1	41213205	1579	DRB1-1469	HRHRFEKDFRVQELP	9	24

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Fusion breakpoint peptide structures of CTPS1-NFYC

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
1694	EERHRHRFEKDFRV	CTPS1	NFYC	chr1	41474386	chr1	41213205	1579

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
7058	PTTSHPVKDFRVQE	CTPS1	NFYC	chr1	41471766	chr1	41213206	1426

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of CTPS1-NFYC

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	1694	EERHRHRFEKDFRV	-7.88372	-7.99712
HLA-B14:02	3BVN	1694	EERHRHRFEKDFRV	-5.34165	-6.37695
HLA-B52:01	3W39	1694	EERHRHRFEKDFRV	-6.76573	-6.87913
HLA-B52:01	3W39	1694	EERHRHRFEKDFRV	-5.28832	-6.32362
HLA-A24:02	5HGA	1694	EERHRHRFEKDFRV	-7.78551	-7.89891
HLA-A24:02	5HGA	1694	EERHRHRFEKDFRV	-5.13058	-6.16588
HLA-B44:05	3DX8	1694	EERHRHRFEKDFRV	-6.02716	-6.14056
HLA-B44:05	3DX8	1694	EERHRHRFEKDFRV	-3.54334	-4.57864
HLA-A02:01	6TDR	1694	EERHRHRFEKDFRV	-4.9342	-5.0476
HLA-A02:01	6TDR	1694	EERHRHRFEKDFRV	-1.37769	-2.41299
HLA-B14:02	3BVN	7058	PTTSHPVKDFRVQE	-5.85492	-6.05172
HLA-B52:01	3W39	7058	PTTSHPVKDFRVQE	-6.04328	-6.24008
HLA-A11:01	4UQ2	7058	PTTSHPVKDFRVQE	-6.44511	-6.64191
HLA-A24:02	5HGA	7058	PTTSHPVKDFRVQE	-8.68636	-8.88316
HLA-A24:02	5HGA	7058	PTTSHPVKDFRVQE	-5.74283	-6.49163
HLA-B44:05	3DX8	7058	PTTSHPVKDFRVQE	-6.54023	-6.73703
HLA-B44:05	3DX8	7058	PTTSHPVKDFRVQE	-2.27806	-3.02686

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Vaccine Design for the FusionNeoAntigens of CTPS1-NFYC

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
CTPS1-NFYC	chr1	41471766	chr1	41213206	10	21	HPVKDFRVQEL	CATCCCGTGAAAGACTTCCGAGTGCAGGAACTC
CTPS1-NFYC	chr1	41471766	chr1	41213206	12	21	VKDFRVQEL	GTGAAAGACTTCCGAGTGCAGGAACTC
CTPS1-NFYC	chr1	41471766	chr1	41213206	7	16	TTSHPVKDF	ACGACCAGTCATCCCGTGAAAGACTTC
CTPS1-NFYC	chr1	41471766	chr1	41213206	9	18	SHPVKDFRV	AGTCATCCCGTGAAAGACTTCCGAGTG
CTPS1-NFYC	chr1	41474386	chr1	41213205	10	20	RHRFEKDFRV	CGATTTGAGAAAGACTTCCGAGTGCAGGAA
CTPS1-NFYC	chr1	41474386	chr1	41213205	11	20	HRFEKDFRV	TTTGAGAAAGACTTCCGAGTGCAGGAA
CTPS1-NFYC	chr1	41474386	chr1	41213205	4	14	YLEERHRHRF	GAAGAGAGGCACCGCCACCGATTTGAGAAA
CTPS1-NFYC	chr1	41474386	chr1	41213205	5	14	LEERHRHRF	GAGAGGCACCGCCACCGATTTGAGAAA
CTPS1-NFYC	chr1	41474386	chr1	41213205	6	14	EERHRHRF	AGGCACCGCCACCGATTTGAGAAA
CTPS1-NFYC	chr1	41474386	chr1	41213205	9	18	HRHRFEKDF	CACCGATTTGAGAAAGACTTCCGAGTG

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
CTPS1-NFYC	chr1	41471766	chr1	41213206	0	15	NSTEFDPTTSHPVKD	AATTCTACAGAGTTTGACCCTACGACCAGTCATCCCGTGAAAGAC
CTPS1-NFYC	chr1	41471766	chr1	41213206	1	16	STEFDPTTSHPVKDF	TCTACAGAGTTTGACCCTACGACCAGTCATCCCGTGAAAGACTTC
CTPS1-NFYC	chr1	41471766	chr1	41213206	10	25	HPVKDFRVQELPLAR	CATCCCGTGAAAGACTTCCGAGTGCAGGAACTCCCACTGGCTCGT
CTPS1-NFYC	chr1	41471766	chr1	41213206	11	26	PVKDFRVQELPLARI	CCCGTGAAAGACTTCCGAGTGCAGGAACTCCCACTGGCTCGTATT
CTPS1-NFYC	chr1	41471766	chr1	41213206	2	17	TEFDPTTSHPVKDFR	ACAGAGTTTGACCCTACGACCAGTCATCCCGTGAAAGACTTCCGA
CTPS1-NFYC	chr1	41471766	chr1	41213206	3	18	EFDPTTSHPVKDFRV	GAGTTTGACCCTACGACCAGTCATCCCGTGAAAGACTTCCGAGTG
CTPS1-NFYC	chr1	41474386	chr1	41213205	1	16	DADYLEERHRHRFEK	GACTACTTGGAAGAGAGGCACCGCCACCGATTTGAGAAAGACTTC
CTPS1-NFYC	chr1	41474386	chr1	41213205	10	25	RHRFEKDFRVQELPL	CGATTTGAGAAAGACTTCCGAGTGCAGGAACTCCCACTGGCTCGT
CTPS1-NFYC	chr1	41474386	chr1	41213205	11	26	HRFEKDFRVQELPLA	TTTGAGAAAGACTTCCGAGTGCAGGAACTCCCACTGGCTCGTATT
CTPS1-NFYC	chr1	41474386	chr1	41213205	2	17	ADYLEERHRHRFEKD	TACTTGGAAGAGAGGCACCGCCACCGATTTGAGAAAGACTTCCGA
CTPS1-NFYC	chr1	41474386	chr1	41213205	8	23	RHRHRFEKDFRVQEL	CGCCACCGATTTGAGAAAGACTTCCGAGTGCAGGAACTCCCACTG
CTPS1-NFYC	chr1	41474386	chr1	41213205	9	24	HRHRFEKDFRVQELP	CACCGATTTGAGAAAGACTTCCGAGTGCAGGAACTCCCACTGGCT

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Information of the samples that have these potential fusion neoantigens of CTPS1-NFYC

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
STAD	CTPS1-NFYC	chr1	41471766	ENST00000372616	chr1	41213206	ENST00000308733	TCGA-FP-8631-01A
STAD	CTPS1-NFYC	chr1	41474386	ENST00000372616	chr1	41213205	ENST00000308733	TCGA-FP-8631

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Potential target of CAR-T therapy development for CTPS1-NFYC

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to CTPS1-NFYC

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CTPS1-NFYC

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)