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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:ADCYAP1R1-GHRHR

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ADCYAP1R1-GHRHR
FusionPDB ID: 2281
FusionGDB2.0 ID: 2281
HgeneTgene
Gene symbol

ADCYAP1R1

GHRHR

Gene ID

117

2692

Gene nameADCYAP receptor type Igrowth hormone releasing hormone receptor
SynonymsPAC1|PAC1R|PACAPR|PACAPRIGHRFR|GRFR|IGHD1B|IGHD4
Cytomap

7p14.3

7p14.3

Type of geneprotein-codingprotein-coding
Descriptionpituitary adenylate cyclase-activating polypeptide type I receptorPACAP receptor 1PACAP type I receptorPACAP-R1adenylate cyclase activating polypeptide 1 (pituitary) receptor type Ipituitary adenylate cyclase activating polypeptide 1 receptor type I growth hormone-releasing hormone receptorGHRH receptorGRF receptor
Modification date2020031320200315
UniProtAcc

P41586

Main function of 5'-partner protein: FUNCTION: This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.		.
Ensembl transtripts involved in fusion geneENST idsENST00000304166, ENST00000396211, 
ENST00000409363, ENST00000409489, 
ENST00000461424, ENST00000409316, 
ENST00000326139, ENST00000409904, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 7 X 3=1262 X 2 X 2=8
# samples 72
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Fusion gene context

PubMed: ADCYAP1R1 [Title/Abstract] AND GHRHR [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: ADCYAP1R1 [Title/Abstract] AND GHRHR [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ADCYAP1R1(31139824)-GHRHR(31014586), # samples:2
Anticipated loss of major functional domain due to fusion event.ADCYAP1R1-GHRHR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCYAP1R1-GHRHR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCYAP1R1-GHRHR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCYAP1R1-GHRHR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCYAP1R1-GHRHR seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ADCYAP1R1-GHRHR seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGHRHR

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

1333056|7680413

TgeneGHRHR

GO:0008284

positive regulation of cell proliferation

12867592

TgeneGHRHR

GO:0043627

response to estrogen

9482665

TgeneGHRHR

GO:0051384

response to glucocorticoid

9482665



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:31139824/chr7:31014586)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across ADCYAP1R1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GHRHR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396211ADCYAP1R1chr731139824+ENST00000326139GHRHRchr731014586+19451201231660545
ENST00000396211ADCYAP1R1chr731139824+ENST00000409904GHRHRchr731014586+19361201231660545
ENST00000409489ADCYAP1R1chr731139824+ENST00000326139GHRHRchr731014586+19841240261699557
ENST00000409489ADCYAP1R1chr731139824+ENST00000409904GHRHRchr731014586+19751240261699557
ENST00000304166ADCYAP1R1chr731132349+ENST00000326139GHRHRchr731014586+207913352411794517
ENST00000304166ADCYAP1R1chr731132349+ENST00000409904GHRHRchr731014586+207013352411794517
ENST00000409363ADCYAP1R1chr731132349+ENST00000326139GHRHRchr731014586+195012061751665496
ENST00000409363ADCYAP1R1chr731132349+ENST00000409904GHRHRchr731014586+194112061751665496
ENST00000396211ADCYAP1R1chr731132349+ENST00000326139GHRHRchr731014586+18611117231576517
ENST00000396211ADCYAP1R1chr731132349+ENST00000409904GHRHRchr731014586+18521117231576517
ENST00000409489ADCYAP1R1chr731132349+ENST00000326139GHRHRchr731014586+18161072261531501
ENST00000409489ADCYAP1R1chr731132349+ENST00000409904GHRHRchr731014586+18071072261531501

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396211ENST00000326139ADCYAP1R1chr731139824+GHRHRchr731014586+0.0027581420.99724185
ENST00000396211ENST00000409904ADCYAP1R1chr731139824+GHRHRchr731014586+0.0029177040.9970823
ENST00000409489ENST00000326139ADCYAP1R1chr731139824+GHRHRchr731014586+0.0038271770.99617285
ENST00000409489ENST00000409904ADCYAP1R1chr731139824+GHRHRchr731014586+0.0040482430.9959518
ENST00000304166ENST00000326139ADCYAP1R1chr731132349+GHRHRchr731014586+0.0021074720.99789256
ENST00000304166ENST00000409904ADCYAP1R1chr731132349+GHRHRchr731014586+0.0021893230.99781066
ENST00000409363ENST00000326139ADCYAP1R1chr731132349+GHRHRchr731014586+0.0032764390.9967236
ENST00000409363ENST00000409904ADCYAP1R1chr731132349+GHRHRchr731014586+0.0034623610.9965377
ENST00000396211ENST00000326139ADCYAP1R1chr731132349+GHRHRchr731014586+0.0017775080.99822253
ENST00000396211ENST00000409904ADCYAP1R1chr731132349+GHRHRchr731014586+0.0018762080.9981238
ENST00000409489ENST00000326139ADCYAP1R1chr731132349+GHRHRchr731014586+0.0018802570.9981198
ENST00000409489ENST00000409904ADCYAP1R1chr731132349+GHRHRchr731014586+0.0019860230.998014

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for ADCYAP1R1-GHRHR

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
ADCYAP1R1chr731132349GHRHRchr7310145861072111DFGDSNSLDLSDMGVVSRNCTEDGWS
ADCYAP1R1chr731132349GHRHRchr7310145861117127DFGDSNSLDLSDMGVVSRNCTEDGWS
ADCYAP1R1chr731132349GHRHRchr7310145861206106PELFRIFNPDQDMGVVSRNCTEDGWS
ADCYAP1R1chr731132349GHRHRchr7310145861335127DFGDSNSLDLSDMGVVSRNCTEDGWS
ADCYAP1R1chr731139824GHRHRchr7310145861201127DFGDSNSLDLSDMGVVSRNCTEDGWS
ADCYAP1R1chr731139824GHRHRchr7310145861240111DFGDSNSLDLSDMGVVSRNCTEDGWS

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Potential FusionNeoAntigen Information of ADCYAP1R1-GHRHR in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
ADCYAP1R1-GHRHR_31132349_31014586.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
ADCYAP1R1-GHRHRchr731132349chr7310145861335HLA-A02:16SLDLSDMGV0.97340.7254615
ADCYAP1R1-GHRHRchr731132349chr7310145861335HLA-A02:60SLDLSDMGV0.97150.6189615
ADCYAP1R1-GHRHRchr731132349chr7310145861335HLA-A02:30SLDLSDMGV0.97110.6479615
ADCYAP1R1-GHRHRchr731132349chr7310145861335HLA-A02:24SLDLSDMGV0.97110.6479615
ADCYAP1R1-GHRHRchr731132349chr7310145861335HLA-A02:67SLDLSDMGV0.97110.6479615
ADCYAP1R1-GHRHRchr731132349chr7310145861335HLA-A02:27SLDLSDMGV0.96490.6072615
ADCYAP1R1-GHRHRchr731132349chr7310145861335HLA-A02:38SLDLSDMGV0.96460.7061615
ADCYAP1R1-GHRHRchr731132349chr7310145861335HLA-A02:35SLDLSDMGV0.95150.6762615
ADCYAP1R1-GHRHRchr731132349chr7310145861206HLA-B35:03NPDQDMGVV0.78350.9029716
ADCYAP1R1-GHRHRchr731132349chr7310145861206HLA-B35:04NPDQDMGVV0.77130.9513716
ADCYAP1R1-GHRHRchr731132349chr7310145861206HLA-B35:02NPDQDMGVV0.77130.9513716
ADCYAP1R1-GHRHRchr731132349chr7310145861335HLA-A68:24DLSDMGVVSR0.990.5542818
ADCYAP1R1-GHRHRchr731132349chr7310145861335HLA-A68:03DLSDMGVVSR0.98780.5472818
ADCYAP1R1-GHRHRchr731132349chr7310145861335HLA-A68:05DLSDMGVVSR0.95920.5483818
ADCYAP1R1-GHRHRchr731132349chr7310145861335HLA-A34:05DLSDMGVVSR0.93580.5624818
ADCYAP1R1-GHRHRchr731132349chr7310145861335HLA-A34:01DLSDMGVVSR0.93580.5624818
ADCYAP1R1-GHRHRchr731132349chr7310145861206HLA-A02:20RIFNPDQDMGV0.96410.702415
ADCYAP1R1-GHRHRchr731132349chr7310145861335HLA-C05:09SLDLSDMGV0.99910.9711615
ADCYAP1R1-GHRHRchr731132349chr7310145861335HLA-A02:07SLDLSDMGV0.97190.6492615
ADCYAP1R1-GHRHRchr731132349chr7310145861335HLA-A02:01SLDLSDMGV0.97110.6479615
ADCYAP1R1-GHRHRchr731132349chr7310145861206HLA-B35:12NPDQDMGVV0.77130.9513716
ADCYAP1R1-GHRHRchr731132349chr7310145861206HLA-B39:10NPDQDMGVV0.28820.9675716
ADCYAP1R1-GHRHRchr731132349chr7310145861335HLA-A68:01DLSDMGVVSR0.990.5542818
ADCYAP1R1-GHRHRchr731132349chr7310145861335HLA-C05:01SLDLSDMGV0.99910.9711615
ADCYAP1R1-GHRHRchr731132349chr7310145861335HLA-C04:03SLDLSDMGV0.9990.9092615
ADCYAP1R1-GHRHRchr731132349chr7310145861206HLA-B35:09NPDQDMGVV0.77130.9513716

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Potential FusionNeoAntigen Information of ADCYAP1R1-GHRHR in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
ADCYAP1R1-GHRHR_31132349_31014586.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB1-0405PELFRIFNPDQDMGV015
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB1-0409PELFRIFNPDQDMGV015
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB1-0417PELFRIFNPDQDMGV015
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB1-0424PELFRIFNPDQDMGV015
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB1-0429PELFRIFNPDQDMGV015
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB1-0430PELFRIFNPDQDMGV015
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB1-0445PELFRIFNPDQDMGV015
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB1-0448PELFRIFNPDQDMGV015
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB1-0457PELFRIFNPDQDMGV015
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB1-0477PELFRIFNPDQDMGV015
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB1-0480PELFRIFNPDQDMGV015
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB1-0483PELFRIFNPDQDMGV015
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB1-0484PELFRIFNPDQDMGV015
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB1-0486PELFRIFNPDQDMGV015
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB1-0487PELFRIFNPDQDMGV015
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB1-0489PELFRIFNPDQDMGV015
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB1-0832PELFRIFNPDQDMGV015
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB3-0101FRIFNPDQDMGVVSR318
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB3-0104FRIFNPDQDMGVVSR318
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB3-0108FRIFNPDQDMGVVSR318
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB3-0111FRIFNPDQDMGVVSR318
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB3-0112FRIFNPDQDMGVVSR318
ADCYAP1R1-GHRHRchr731132349chr7310145861206DRB3-0113FRIFNPDQDMGVVSR318

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Fusion breakpoint peptide structures of ADCYAP1R1-GHRHR

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
2482FNPDQDMGVVSRNCADCYAP1R1GHRHRchr731132349chr7310145861206
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
8732SLDLSDMGVVSRNCADCYAP1R1GHRHRchr731132349chr7310145861335

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ADCYAP1R1-GHRHR

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN2482FNPDQDMGVVSRNC-7.02924-7.14264
HLA-B14:023BVN2482FNPDQDMGVVSRNC-3.38077-4.41607
HLA-B52:013W392482FNPDQDMGVVSRNC-6.41355-6.52695
HLA-B52:013W392482FNPDQDMGVVSRNC-4.44188-5.47718
HLA-A24:025HGA2482FNPDQDMGVVSRNC-7.76595-8.80125
HLA-A24:025HGA2482FNPDQDMGVVSRNC-7.30892-7.42232
HLA-B44:053DX82482FNPDQDMGVVSRNC-5.65486-5.76826
HLA-B44:053DX82482FNPDQDMGVVSRNC-2.95775-3.99305
HLA-B14:023BVN8732SLDLSDMGVVSRNC-7.9962-8.1096
HLA-B14:023BVN8732SLDLSDMGVVSRNC-5.70842-6.74372
HLA-B52:013W398732SLDLSDMGVVSRNC-6.83737-6.95077
HLA-B52:013W398732SLDLSDMGVVSRNC-4.4836-5.5189
HLA-A11:014UQ28732SLDLSDMGVVSRNC-10.0067-10.1201
HLA-A11:014UQ28732SLDLSDMGVVSRNC-9.03915-10.0745
HLA-A24:025HGA8732SLDLSDMGVVSRNC-6.56204-6.67544
HLA-A24:025HGA8732SLDLSDMGVVSRNC-5.42271-6.45801
HLA-B44:053DX88732SLDLSDMGVVSRNC-7.85648-8.89178
HLA-B44:053DX88732SLDLSDMGVVSRNC-5.3978-5.5112
HLA-A02:016TDR8732SLDLSDMGVVSRNC-3.37154-4.40684

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Vaccine Design for the FusionNeoAntigens of ADCYAP1R1-GHRHR

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
ADCYAP1R1-GHRHRchr731132349chr731014586415RIFNPDQDMGVGGGAGGCAATGAGTCCAGCATCTACTTGTGCTG
ADCYAP1R1-GHRHRchr731132349chr731014586615SLDLSDMGVCAATGAGTCCAGCATCTACTTGTGCTG
ADCYAP1R1-GHRHRchr731132349chr731014586716NPDQDMGVVTGAGTCCAGCATCTACTTGTGCTGGGA
ADCYAP1R1-GHRHRchr731132349chr731014586818DLSDMGVVSRGTCCAGCATCTACTTGTGCTGGGACCTGGA

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
ADCYAP1R1-GHRHRchr731132349chr731014586015PELFRIFNPDQDMGVGTCTCCAGACATGGGAGGCAATGAGTCCAGCATCTACTTGTGCTG
ADCYAP1R1-GHRHRchr731132349chr731014586318FRIFNPDQDMGVVSRCATGGGAGGCAATGAGTCCAGCATCTACTTGTGCTGGGACCTGGA

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Information of the samples that have these potential fusion neoantigens of ADCYAP1R1-GHRHR

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
PCPGADCYAP1R1-GHRHRchr731132349ENST00000304166chr731014586ENST00000326139TCGA-P8-A5KC-01A
PCPGADCYAP1R1-GHRHRchr731132349ENST00000409363chr731014586ENST00000326139TCGA-P8-A5KC-01A

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Potential target of CAR-T therapy development for ADCYAP1R1-GHRHR

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADCYAP1R1chr7:31132349chr7:31014586ENST00000304166+1316156_178348469.0TransmembraneHelical%3B Name%3D1
HgeneADCYAP1R1chr7:31132349chr7:31014586ENST00000304166+1316187_205348469.0TransmembraneHelical%3B Name%3D2
HgeneADCYAP1R1chr7:31132349chr7:31014586ENST00000304166+1316228_253348469.0TransmembraneHelical%3B Name%3D3
HgeneADCYAP1R1chr7:31132349chr7:31014586ENST00000304166+1316269_291348469.0TransmembraneHelical%3B Name%3D4
HgeneADCYAP1R1chr7:31132349chr7:31014586ENST00000304166+1316310_332348469.0TransmembraneHelical%3B Name%3D5
HgeneADCYAP1R1chr7:31132349chr7:31014586ENST00000396211+1216156_178348497.0TransmembraneHelical%3B Name%3D1
HgeneADCYAP1R1chr7:31132349chr7:31014586ENST00000396211+1216187_205348497.0TransmembraneHelical%3B Name%3D2
HgeneADCYAP1R1chr7:31132349chr7:31014586ENST00000396211+1216228_253348497.0TransmembraneHelical%3B Name%3D3
HgeneADCYAP1R1chr7:31132349chr7:31014586ENST00000396211+1216269_291348497.0TransmembraneHelical%3B Name%3D4
HgeneADCYAP1R1chr7:31132349chr7:31014586ENST00000396211+1216310_332348497.0TransmembraneHelical%3B Name%3D5
HgeneADCYAP1R1chr7:31132349chr7:31014586ENST00000409363+1114156_178327448.0TransmembraneHelical%3B Name%3D1
HgeneADCYAP1R1chr7:31132349chr7:31014586ENST00000409363+1114187_205327448.0TransmembraneHelical%3B Name%3D2
HgeneADCYAP1R1chr7:31132349chr7:31014586ENST00000409363+1114228_253327448.0TransmembraneHelical%3B Name%3D3
HgeneADCYAP1R1chr7:31132349chr7:31014586ENST00000409363+1114269_291327448.0TransmembraneHelical%3B Name%3D4
HgeneADCYAP1R1chr7:31139824chr7:31014586ENST00000396211+1316156_178376497.0TransmembraneHelical%3B Name%3D1
HgeneADCYAP1R1chr7:31139824chr7:31014586ENST00000396211+1316187_205376497.0TransmembraneHelical%3B Name%3D2
HgeneADCYAP1R1chr7:31139824chr7:31014586ENST00000396211+1316228_253376497.0TransmembraneHelical%3B Name%3D3
HgeneADCYAP1R1chr7:31139824chr7:31014586ENST00000396211+1316269_291376497.0TransmembraneHelical%3B Name%3D4
HgeneADCYAP1R1chr7:31139824chr7:31014586ENST00000396211+1316310_332376497.0TransmembraneHelical%3B Name%3D5
HgeneADCYAP1R1chr7:31139824chr7:31014586ENST00000396211+1316351_371376497.0TransmembraneHelical%3B Name%3D6
TgeneGHRHRchr7:31132349chr7:31014586ENST00000326139713281_3040424.0TransmembraneHelical%3B Name%3D5
TgeneGHRHRchr7:31132349chr7:31014586ENST00000326139713330_3480424.0TransmembraneHelical%3B Name%3D6
TgeneGHRHRchr7:31132349chr7:31014586ENST00000326139713362_3810424.0TransmembraneHelical%3B Name%3D7
TgeneGHRHRchr7:31139824chr7:31014586ENST00000326139713281_3040424.0TransmembraneHelical%3B Name%3D5
TgeneGHRHRchr7:31139824chr7:31014586ENST00000326139713330_3480424.0TransmembraneHelical%3B Name%3D6
TgeneGHRHRchr7:31139824chr7:31014586ENST00000326139713362_3810424.0TransmembraneHelical%3B Name%3D7

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to ADCYAP1R1-GHRHR

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ADCYAP1R1-GHRHR

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource