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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:DLG1-BDH1

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DLG1-BDH1
FusionPDB ID: 23032
FusionGDB2.0 ID: 23032
HgeneTgene
Gene symbol

DLG1

BDH1

Gene ID

1739

622

Gene namediscs large MAGUK scaffold protein 13-hydroxybutyrate dehydrogenase 1
SynonymsDLGH1|SAP-97|SAP97|hdlgBDH|SDR9C1
Cytomap

3q29

3q29

Type of geneprotein-codingprotein-coding
Descriptiondisks large homolog 1dJ1061C18.1.1discs large homolog 1, scribble cell polarity complex componentpresynaptic protein SAP97synapse-associated protein 97D-beta-hydroxybutyrate dehydrogenase, mitochondrial(R)-3-hydroxybutyrate dehydrogenase3-hydroxybutyrate dehydrogenase (heart, mitochondrial)3-hydroxybutyrate dehydrogenase, type 1epididymis secretory sperm binding proteinshort chain dehydrogenase/red
Modification date2020032720200313
UniProtAcc

Q12959

Main function of 5'-partner protein: FUNCTION: Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}.

Q02338

Main function of 5'-partner protein:
Ensembl transtripts involved in fusion geneENST idsENST00000314062, ENST00000346964, 
ENST00000357674, ENST00000392382, 
ENST00000419354, ENST00000422288, 
ENST00000448528, ENST00000450955, 
ENST00000443183, ENST00000452595, 
ENST00000485409, 
ENST00000358186, 
ENST00000392378, ENST00000392379, 
ENST00000441275, ENST00000476764, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score27 X 18 X 14=68048 X 8 X 8=512
# samples 4014
** MAII scorelog2(40/6804*10)=-4.08831123588866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/512*10)=-1.87071698305503
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: DLG1 [Title/Abstract] AND BDH1 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: DLG1 [Title/Abstract] AND BDH1 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DLG1(197009549)-BDH1(197249652), # samples:2
Anticipated loss of major functional domain due to fusion event.DLG1-BDH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DLG1-BDH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DLG1-BDH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DLG1-BDH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DLG1-BDH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DLG1-BDH1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
DLG1-BDH1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDLG1

GO:0001935

endothelial cell proliferation

14699157

HgeneDLG1

GO:0007015

actin filament organization

14699157

HgeneDLG1

GO:0030866

cortical actin cytoskeleton organization

14699157

HgeneDLG1

GO:0042391

regulation of membrane potential

12970345

HgeneDLG1

GO:0043268

positive regulation of potassium ion transport

12970345

HgeneDLG1

GO:0070830

bicellular tight junction assembly

17332497

HgeneDLG1

GO:0098609

cell-cell adhesion

14699157

HgeneDLG1

GO:1902473

regulation of protein localization to synapse

23676497

HgeneDLG1

GO:1903078

positive regulation of protein localization to plasma membrane

12970345



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:197009549/chr3:197249652)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across DLG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BDH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000357674DLG1chr3197009549-ENST00000392379BDH1chr3197249652-33855081901272360
ENST00000357674DLG1chr3197009549-ENST00000392378BDH1chr3197249652-33855081901272360
ENST00000357674DLG1chr3197009549-ENST00000358186BDH1chr3197249652-33855081901272360
ENST00000357674DLG1chr3197009549-ENST00000441275BDH1chr3197249652-15745081901272360
ENST00000314062DLG1chr3197009549-ENST00000392379BDH1chr3197249652-33855081901272360
ENST00000314062DLG1chr3197009549-ENST00000392378BDH1chr3197249652-33855081901272360
ENST00000314062DLG1chr3197009549-ENST00000358186BDH1chr3197249652-33855081901272360
ENST00000314062DLG1chr3197009549-ENST00000441275BDH1chr3197249652-15745081901272360
ENST00000346964DLG1chr3197009549-ENST00000392379BDH1chr3197249652-33855081901272360
ENST00000346964DLG1chr3197009549-ENST00000392378BDH1chr3197249652-33855081901272360
ENST00000346964DLG1chr3197009549-ENST00000358186BDH1chr3197249652-33855081901272360
ENST00000346964DLG1chr3197009549-ENST00000441275BDH1chr3197249652-15745081901272360
ENST00000419354DLG1chr3197009549-ENST00000392379BDH1chr3197249652-34826052871369360
ENST00000419354DLG1chr3197009549-ENST00000392378BDH1chr3197249652-34826052871369360
ENST00000419354DLG1chr3197009549-ENST00000358186BDH1chr3197249652-34826052871369360
ENST00000419354DLG1chr3197009549-ENST00000441275BDH1chr3197249652-16716052871369360
ENST00000422288DLG1chr3197009549-ENST00000392379BDH1chr3197249652-319531801082360
ENST00000422288DLG1chr3197009549-ENST00000392378BDH1chr3197249652-319531801082360
ENST00000422288DLG1chr3197009549-ENST00000358186BDH1chr3197249652-319531801082360
ENST00000422288DLG1chr3197009549-ENST00000441275BDH1chr3197249652-138431801082360
ENST00000448528DLG1chr3197009549-ENST00000392379BDH1chr3197249652-33855081901272360
ENST00000448528DLG1chr3197009549-ENST00000392378BDH1chr3197249652-33855081901272360
ENST00000448528DLG1chr3197009549-ENST00000358186BDH1chr3197249652-33855081901272360
ENST00000448528DLG1chr3197009549-ENST00000441275BDH1chr3197249652-15745081901272360
ENST00000450955DLG1chr3197009549-ENST00000392379BDH1chr3197249652-319531801082360
ENST00000450955DLG1chr3197009549-ENST00000392378BDH1chr3197249652-319531801082360
ENST00000450955DLG1chr3197009549-ENST00000358186BDH1chr3197249652-319531801082360
ENST00000450955DLG1chr3197009549-ENST00000441275BDH1chr3197249652-138431801082360
ENST00000392382DLG1chr3197009549-ENST00000392379BDH1chr3197249652-3269392741156360
ENST00000392382DLG1chr3197009549-ENST00000392378BDH1chr3197249652-3269392741156360
ENST00000392382DLG1chr3197009549-ENST00000358186BDH1chr3197249652-3269392741156360
ENST00000392382DLG1chr3197009549-ENST00000441275BDH1chr3197249652-1458392741156360
ENST00000357674DLG1chr3197023216-ENST00000392379BDH1chr3197241287-3076341190963257
ENST00000357674DLG1chr3197023216-ENST00000392378BDH1chr3197241287-3076341190963257
ENST00000357674DLG1chr3197023216-ENST00000358186BDH1chr3197241287-3076341190963257
ENST00000357674DLG1chr3197023216-ENST00000441275BDH1chr3197241287-1265341190963257
ENST00000314062DLG1chr3197023216-ENST00000392379BDH1chr3197241287-3076341190963257
ENST00000314062DLG1chr3197023216-ENST00000392378BDH1chr3197241287-3076341190963257
ENST00000314062DLG1chr3197023216-ENST00000358186BDH1chr3197241287-3076341190963257
ENST00000314062DLG1chr3197023216-ENST00000441275BDH1chr3197241287-1265341190963257
ENST00000346964DLG1chr3197023216-ENST00000392379BDH1chr3197241287-3076341190963257
ENST00000346964DLG1chr3197023216-ENST00000392378BDH1chr3197241287-3076341190963257
ENST00000346964DLG1chr3197023216-ENST00000358186BDH1chr3197241287-3076341190963257
ENST00000346964DLG1chr3197023216-ENST00000441275BDH1chr3197241287-1265341190963257
ENST00000419354DLG1chr3197023216-ENST00000392379BDH1chr3197241287-31734382871060257
ENST00000419354DLG1chr3197023216-ENST00000392378BDH1chr3197241287-31734382871060257
ENST00000419354DLG1chr3197023216-ENST00000358186BDH1chr3197241287-31734382871060257
ENST00000419354DLG1chr3197023216-ENST00000441275BDH1chr3197241287-13624382871060257
ENST00000422288DLG1chr3197023216-ENST00000392379BDH1chr3197241287-28861510773257
ENST00000422288DLG1chr3197023216-ENST00000392378BDH1chr3197241287-28861510773257
ENST00000422288DLG1chr3197023216-ENST00000358186BDH1chr3197241287-28861510773257
ENST00000422288DLG1chr3197023216-ENST00000441275BDH1chr3197241287-10751510773257
ENST00000448528DLG1chr3197023216-ENST00000392379BDH1chr3197241287-3076341190963257
ENST00000448528DLG1chr3197023216-ENST00000392378BDH1chr3197241287-3076341190963257
ENST00000448528DLG1chr3197023216-ENST00000358186BDH1chr3197241287-3076341190963257
ENST00000448528DLG1chr3197023216-ENST00000441275BDH1chr3197241287-1265341190963257
ENST00000450955DLG1chr3197023216-ENST00000392379BDH1chr3197241287-28861510773257
ENST00000450955DLG1chr3197023216-ENST00000392378BDH1chr3197241287-28861510773257
ENST00000450955DLG1chr3197023216-ENST00000358186BDH1chr3197241287-28861510773257
ENST00000450955DLG1chr3197023216-ENST00000441275BDH1chr3197241287-10751510773257
ENST00000392382DLG1chr3197023216-ENST00000392379BDH1chr3197241287-296022574847257
ENST00000392382DLG1chr3197023216-ENST00000392378BDH1chr3197241287-296022574847257
ENST00000392382DLG1chr3197023216-ENST00000358186BDH1chr3197241287-296022574847257
ENST00000392382DLG1chr3197023216-ENST00000441275BDH1chr3197241287-114922574847257
ENST00000357674DLG1chr3197009550-ENST00000392379BDH1chr3197249652-33855081901272360
ENST00000357674DLG1chr3197009550-ENST00000392378BDH1chr3197249652-33855081901272360
ENST00000357674DLG1chr3197009550-ENST00000358186BDH1chr3197249652-33855081901272360
ENST00000357674DLG1chr3197009550-ENST00000441275BDH1chr3197249652-15745081901272360
ENST00000314062DLG1chr3197009550-ENST00000392379BDH1chr3197249652-33855081901272360
ENST00000314062DLG1chr3197009550-ENST00000392378BDH1chr3197249652-33855081901272360
ENST00000314062DLG1chr3197009550-ENST00000358186BDH1chr3197249652-33855081901272360
ENST00000314062DLG1chr3197009550-ENST00000441275BDH1chr3197249652-15745081901272360
ENST00000346964DLG1chr3197009550-ENST00000392379BDH1chr3197249652-33855081901272360
ENST00000346964DLG1chr3197009550-ENST00000392378BDH1chr3197249652-33855081901272360
ENST00000346964DLG1chr3197009550-ENST00000358186BDH1chr3197249652-33855081901272360
ENST00000346964DLG1chr3197009550-ENST00000441275BDH1chr3197249652-15745081901272360
ENST00000419354DLG1chr3197009550-ENST00000392379BDH1chr3197249652-34826052871369360
ENST00000419354DLG1chr3197009550-ENST00000392378BDH1chr3197249652-34826052871369360
ENST00000419354DLG1chr3197009550-ENST00000358186BDH1chr3197249652-34826052871369360
ENST00000419354DLG1chr3197009550-ENST00000441275BDH1chr3197249652-16716052871369360
ENST00000422288DLG1chr3197009550-ENST00000392379BDH1chr3197249652-319531801082360
ENST00000422288DLG1chr3197009550-ENST00000392378BDH1chr3197249652-319531801082360
ENST00000422288DLG1chr3197009550-ENST00000358186BDH1chr3197249652-319531801082360
ENST00000422288DLG1chr3197009550-ENST00000441275BDH1chr3197249652-138431801082360
ENST00000448528DLG1chr3197009550-ENST00000392379BDH1chr3197249652-33855081901272360
ENST00000448528DLG1chr3197009550-ENST00000392378BDH1chr3197249652-33855081901272360
ENST00000448528DLG1chr3197009550-ENST00000358186BDH1chr3197249652-33855081901272360
ENST00000448528DLG1chr3197009550-ENST00000441275BDH1chr3197249652-15745081901272360
ENST00000450955DLG1chr3197009550-ENST00000392379BDH1chr3197249652-319531801082360
ENST00000450955DLG1chr3197009550-ENST00000392378BDH1chr3197249652-319531801082360
ENST00000450955DLG1chr3197009550-ENST00000358186BDH1chr3197249652-319531801082360
ENST00000450955DLG1chr3197009550-ENST00000441275BDH1chr3197249652-138431801082360
ENST00000392382DLG1chr3197009550-ENST00000392379BDH1chr3197249652-3269392741156360
ENST00000392382DLG1chr3197009550-ENST00000392378BDH1chr3197249652-3269392741156360
ENST00000392382DLG1chr3197009550-ENST00000358186BDH1chr3197249652-3269392741156360
ENST00000392382DLG1chr3197009550-ENST00000441275BDH1chr3197249652-1458392741156360
ENST00000357674DLG1chr3197023217-ENST00000392379BDH1chr3197241287-3076341190963257
ENST00000357674DLG1chr3197023217-ENST00000392378BDH1chr3197241287-3076341190963257
ENST00000357674DLG1chr3197023217-ENST00000358186BDH1chr3197241287-3076341190963257
ENST00000357674DLG1chr3197023217-ENST00000441275BDH1chr3197241287-1265341190963257
ENST00000314062DLG1chr3197023217-ENST00000392379BDH1chr3197241287-3076341190963257
ENST00000314062DLG1chr3197023217-ENST00000392378BDH1chr3197241287-3076341190963257
ENST00000314062DLG1chr3197023217-ENST00000358186BDH1chr3197241287-3076341190963257
ENST00000314062DLG1chr3197023217-ENST00000441275BDH1chr3197241287-1265341190963257
ENST00000346964DLG1chr3197023217-ENST00000392379BDH1chr3197241287-3076341190963257
ENST00000346964DLG1chr3197023217-ENST00000392378BDH1chr3197241287-3076341190963257
ENST00000346964DLG1chr3197023217-ENST00000358186BDH1chr3197241287-3076341190963257
ENST00000346964DLG1chr3197023217-ENST00000441275BDH1chr3197241287-1265341190963257
ENST00000419354DLG1chr3197023217-ENST00000392379BDH1chr3197241287-31734382871060257
ENST00000419354DLG1chr3197023217-ENST00000392378BDH1chr3197241287-31734382871060257
ENST00000419354DLG1chr3197023217-ENST00000358186BDH1chr3197241287-31734382871060257
ENST00000419354DLG1chr3197023217-ENST00000441275BDH1chr3197241287-13624382871060257
ENST00000422288DLG1chr3197023217-ENST00000392379BDH1chr3197241287-28861510773257
ENST00000422288DLG1chr3197023217-ENST00000392378BDH1chr3197241287-28861510773257
ENST00000422288DLG1chr3197023217-ENST00000358186BDH1chr3197241287-28861510773257
ENST00000422288DLG1chr3197023217-ENST00000441275BDH1chr3197241287-10751510773257
ENST00000448528DLG1chr3197023217-ENST00000392379BDH1chr3197241287-3076341190963257
ENST00000448528DLG1chr3197023217-ENST00000392378BDH1chr3197241287-3076341190963257
ENST00000448528DLG1chr3197023217-ENST00000358186BDH1chr3197241287-3076341190963257
ENST00000448528DLG1chr3197023217-ENST00000441275BDH1chr3197241287-1265341190963257
ENST00000450955DLG1chr3197023217-ENST00000392379BDH1chr3197241287-28861510773257
ENST00000450955DLG1chr3197023217-ENST00000392378BDH1chr3197241287-28861510773257
ENST00000450955DLG1chr3197023217-ENST00000358186BDH1chr3197241287-28861510773257
ENST00000450955DLG1chr3197023217-ENST00000441275BDH1chr3197241287-10751510773257
ENST00000392382DLG1chr3197023217-ENST00000392379BDH1chr3197241287-296022574847257
ENST00000392382DLG1chr3197023217-ENST00000392378BDH1chr3197241287-296022574847257
ENST00000392382DLG1chr3197023217-ENST00000358186BDH1chr3197241287-296022574847257
ENST00000392382DLG1chr3197023217-ENST00000441275BDH1chr3197241287-114922574847257
ENST00000357674DLG1chr3196817783-ENST00000358186BDH1chr3197239235-443318511901962590
ENST00000314062DLG1chr3196817783-ENST00000358186BDH1chr3197239235-437917971901908572
ENST00000346964DLG1chr3196817783-ENST00000358186BDH1chr3197239235-453219501902061623
ENST00000419354DLG1chr3196817783-ENST00000358186BDH1chr3197239235-462920472872158623
ENST00000452595DLG1chr3196817783-ENST00000358186BDH1chr3197239235-431717352961846516
ENST00000422288DLG1chr3196817783-ENST00000358186BDH1chr3197239235-4189160701718572
ENST00000448528DLG1chr3196817783-ENST00000358186BDH1chr3197239235-453219501902061623
ENST00000443183DLG1chr3196817783-ENST00000358186BDH1chr3197239235-40441462231573516
ENST00000450955DLG1chr3196817783-ENST00000358186BDH1chr3197239235-4243166101772590
ENST00000392382DLG1chr3196817783-ENST00000358186BDH1chr3197239235-43171735741846590

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357674ENST00000392379DLG1chr3197009549-BDH1chr3197249652-0.0017431580.99825686
ENST00000357674ENST00000392378DLG1chr3197009549-BDH1chr3197249652-0.0017431580.99825686
ENST00000357674ENST00000358186DLG1chr3197009549-BDH1chr3197249652-0.0017431580.99825686
ENST00000357674ENST00000441275DLG1chr3197009549-BDH1chr3197249652-0.0033023410.99669766
ENST00000314062ENST00000392379DLG1chr3197009549-BDH1chr3197249652-0.0017431580.99825686
ENST00000314062ENST00000392378DLG1chr3197009549-BDH1chr3197249652-0.0017431580.99825686
ENST00000314062ENST00000358186DLG1chr3197009549-BDH1chr3197249652-0.0017431580.99825686
ENST00000314062ENST00000441275DLG1chr3197009549-BDH1chr3197249652-0.0033023410.99669766
ENST00000346964ENST00000392379DLG1chr3197009549-BDH1chr3197249652-0.0017431580.99825686
ENST00000346964ENST00000392378DLG1chr3197009549-BDH1chr3197249652-0.0017431580.99825686
ENST00000346964ENST00000358186DLG1chr3197009549-BDH1chr3197249652-0.0017431580.99825686
ENST00000346964ENST00000441275DLG1chr3197009549-BDH1chr3197249652-0.0033023410.99669766
ENST00000419354ENST00000392379DLG1chr3197009549-BDH1chr3197249652-0.0018564270.99814355
ENST00000419354ENST00000392378DLG1chr3197009549-BDH1chr3197249652-0.0018564270.99814355
ENST00000419354ENST00000358186DLG1chr3197009549-BDH1chr3197249652-0.0018564270.99814355
ENST00000419354ENST00000441275DLG1chr3197009549-BDH1chr3197249652-0.0042784070.9957216
ENST00000422288ENST00000392379DLG1chr3197009549-BDH1chr3197249652-0.0020533940.99794656
ENST00000422288ENST00000392378DLG1chr3197009549-BDH1chr3197249652-0.0020533940.99794656
ENST00000422288ENST00000358186DLG1chr3197009549-BDH1chr3197249652-0.0020533940.99794656
ENST00000422288ENST00000441275DLG1chr3197009549-BDH1chr3197249652-0.0046075380.99539244
ENST00000448528ENST00000392379DLG1chr3197009549-BDH1chr3197249652-0.0017431580.99825686
ENST00000448528ENST00000392378DLG1chr3197009549-BDH1chr3197249652-0.0017431580.99825686
ENST00000448528ENST00000358186DLG1chr3197009549-BDH1chr3197249652-0.0017431580.99825686
ENST00000448528ENST00000441275DLG1chr3197009549-BDH1chr3197249652-0.0033023410.99669766
ENST00000450955ENST00000392379DLG1chr3197009549-BDH1chr3197249652-0.0020533940.99794656
ENST00000450955ENST00000392378DLG1chr3197009549-BDH1chr3197249652-0.0020533940.99794656
ENST00000450955ENST00000358186DLG1chr3197009549-BDH1chr3197249652-0.0020533940.99794656
ENST00000450955ENST00000441275DLG1chr3197009549-BDH1chr3197249652-0.0046075380.99539244
ENST00000392382ENST00000392379DLG1chr3197009549-BDH1chr3197249652-0.0019053170.99809474
ENST00000392382ENST00000392378DLG1chr3197009549-BDH1chr3197249652-0.0019053170.99809474
ENST00000392382ENST00000358186DLG1chr3197009549-BDH1chr3197249652-0.0019053170.99809474
ENST00000392382ENST00000441275DLG1chr3197009549-BDH1chr3197249652-0.0039141770.99608576
ENST00000357674ENST00000392379DLG1chr3197023216-BDH1chr3197241287-0.0026353210.9973647
ENST00000357674ENST00000392378DLG1chr3197023216-BDH1chr3197241287-0.0026353210.9973647
ENST00000357674ENST00000358186DLG1chr3197023216-BDH1chr3197241287-0.0026353210.9973647
ENST00000357674ENST00000441275DLG1chr3197023216-BDH1chr3197241287-0.0029679980.99703205
ENST00000314062ENST00000392379DLG1chr3197023216-BDH1chr3197241287-0.0026353210.9973647
ENST00000314062ENST00000392378DLG1chr3197023216-BDH1chr3197241287-0.0026353210.9973647
ENST00000314062ENST00000358186DLG1chr3197023216-BDH1chr3197241287-0.0026353210.9973647
ENST00000314062ENST00000441275DLG1chr3197023216-BDH1chr3197241287-0.0029679980.99703205
ENST00000346964ENST00000392379DLG1chr3197023216-BDH1chr3197241287-0.0026353210.9973647
ENST00000346964ENST00000392378DLG1chr3197023216-BDH1chr3197241287-0.0026353210.9973647
ENST00000346964ENST00000358186DLG1chr3197023216-BDH1chr3197241287-0.0026353210.9973647
ENST00000346964ENST00000441275DLG1chr3197023216-BDH1chr3197241287-0.0029679980.99703205
ENST00000419354ENST00000392379DLG1chr3197023216-BDH1chr3197241287-0.0028801880.9971198
ENST00000419354ENST00000392378DLG1chr3197023216-BDH1chr3197241287-0.0028801880.9971198
ENST00000419354ENST00000358186DLG1chr3197023216-BDH1chr3197241287-0.0028801880.9971198
ENST00000419354ENST00000441275DLG1chr3197023216-BDH1chr3197241287-0.004541440.9954586
ENST00000422288ENST00000392379DLG1chr3197023216-BDH1chr3197241287-0.0025371230.99746287
ENST00000422288ENST00000392378DLG1chr3197023216-BDH1chr3197241287-0.0025371230.99746287
ENST00000422288ENST00000358186DLG1chr3197023216-BDH1chr3197241287-0.0025371230.99746287
ENST00000422288ENST00000441275DLG1chr3197023216-BDH1chr3197241287-0.0044886410.9955114
ENST00000448528ENST00000392379DLG1chr3197023216-BDH1chr3197241287-0.0026353210.9973647
ENST00000448528ENST00000392378DLG1chr3197023216-BDH1chr3197241287-0.0026353210.9973647
ENST00000448528ENST00000358186DLG1chr3197023216-BDH1chr3197241287-0.0026353210.9973647
ENST00000448528ENST00000441275DLG1chr3197023216-BDH1chr3197241287-0.0029679980.99703205
ENST00000450955ENST00000392379DLG1chr3197023216-BDH1chr3197241287-0.0025371230.99746287
ENST00000450955ENST00000392378DLG1chr3197023216-BDH1chr3197241287-0.0025371230.99746287
ENST00000450955ENST00000358186DLG1chr3197023216-BDH1chr3197241287-0.0025371230.99746287
ENST00000450955ENST00000441275DLG1chr3197023216-BDH1chr3197241287-0.0044886410.9955114
ENST00000392382ENST00000392379DLG1chr3197023216-BDH1chr3197241287-0.0025809950.997419
ENST00000392382ENST00000392378DLG1chr3197023216-BDH1chr3197241287-0.0025809950.997419
ENST00000392382ENST00000358186DLG1chr3197023216-BDH1chr3197241287-0.0025809950.997419
ENST00000392382ENST00000441275DLG1chr3197023216-BDH1chr3197241287-0.003696760.9963032
ENST00000357674ENST00000392379DLG1chr3197009550-BDH1chr3197249652-0.0017431580.99825686
ENST00000357674ENST00000392378DLG1chr3197009550-BDH1chr3197249652-0.0017431580.99825686
ENST00000357674ENST00000358186DLG1chr3197009550-BDH1chr3197249652-0.0017431580.99825686
ENST00000357674ENST00000441275DLG1chr3197009550-BDH1chr3197249652-0.0033023410.99669766
ENST00000314062ENST00000392379DLG1chr3197009550-BDH1chr3197249652-0.0017431580.99825686
ENST00000314062ENST00000392378DLG1chr3197009550-BDH1chr3197249652-0.0017431580.99825686
ENST00000314062ENST00000358186DLG1chr3197009550-BDH1chr3197249652-0.0017431580.99825686
ENST00000314062ENST00000441275DLG1chr3197009550-BDH1chr3197249652-0.0033023410.99669766
ENST00000346964ENST00000392379DLG1chr3197009550-BDH1chr3197249652-0.0017431580.99825686
ENST00000346964ENST00000392378DLG1chr3197009550-BDH1chr3197249652-0.0017431580.99825686
ENST00000346964ENST00000358186DLG1chr3197009550-BDH1chr3197249652-0.0017431580.99825686
ENST00000346964ENST00000441275DLG1chr3197009550-BDH1chr3197249652-0.0033023410.99669766
ENST00000419354ENST00000392379DLG1chr3197009550-BDH1chr3197249652-0.0018564270.99814355
ENST00000419354ENST00000392378DLG1chr3197009550-BDH1chr3197249652-0.0018564270.99814355
ENST00000419354ENST00000358186DLG1chr3197009550-BDH1chr3197249652-0.0018564270.99814355
ENST00000419354ENST00000441275DLG1chr3197009550-BDH1chr3197249652-0.0042784070.9957216
ENST00000422288ENST00000392379DLG1chr3197009550-BDH1chr3197249652-0.0020533940.99794656
ENST00000422288ENST00000392378DLG1chr3197009550-BDH1chr3197249652-0.0020533940.99794656
ENST00000422288ENST00000358186DLG1chr3197009550-BDH1chr3197249652-0.0020533940.99794656
ENST00000422288ENST00000441275DLG1chr3197009550-BDH1chr3197249652-0.0046075380.99539244
ENST00000448528ENST00000392379DLG1chr3197009550-BDH1chr3197249652-0.0017431580.99825686
ENST00000448528ENST00000392378DLG1chr3197009550-BDH1chr3197249652-0.0017431580.99825686
ENST00000448528ENST00000358186DLG1chr3197009550-BDH1chr3197249652-0.0017431580.99825686
ENST00000448528ENST00000441275DLG1chr3197009550-BDH1chr3197249652-0.0033023410.99669766
ENST00000450955ENST00000392379DLG1chr3197009550-BDH1chr3197249652-0.0020533940.99794656
ENST00000450955ENST00000392378DLG1chr3197009550-BDH1chr3197249652-0.0020533940.99794656
ENST00000450955ENST00000358186DLG1chr3197009550-BDH1chr3197249652-0.0020533940.99794656
ENST00000450955ENST00000441275DLG1chr3197009550-BDH1chr3197249652-0.0046075380.99539244
ENST00000392382ENST00000392379DLG1chr3197009550-BDH1chr3197249652-0.0019053170.99809474
ENST00000392382ENST00000392378DLG1chr3197009550-BDH1chr3197249652-0.0019053170.99809474
ENST00000392382ENST00000358186DLG1chr3197009550-BDH1chr3197249652-0.0019053170.99809474
ENST00000392382ENST00000441275DLG1chr3197009550-BDH1chr3197249652-0.0039141770.99608576
ENST00000357674ENST00000392379DLG1chr3197023217-BDH1chr3197241287-0.0026353210.9973647
ENST00000357674ENST00000392378DLG1chr3197023217-BDH1chr3197241287-0.0026353210.9973647
ENST00000357674ENST00000358186DLG1chr3197023217-BDH1chr3197241287-0.0026353210.9973647
ENST00000357674ENST00000441275DLG1chr3197023217-BDH1chr3197241287-0.0029679980.99703205
ENST00000314062ENST00000392379DLG1chr3197023217-BDH1chr3197241287-0.0026353210.9973647
ENST00000314062ENST00000392378DLG1chr3197023217-BDH1chr3197241287-0.0026353210.9973647
ENST00000314062ENST00000358186DLG1chr3197023217-BDH1chr3197241287-0.0026353210.9973647
ENST00000314062ENST00000441275DLG1chr3197023217-BDH1chr3197241287-0.0029679980.99703205
ENST00000346964ENST00000392379DLG1chr3197023217-BDH1chr3197241287-0.0026353210.9973647
ENST00000346964ENST00000392378DLG1chr3197023217-BDH1chr3197241287-0.0026353210.9973647
ENST00000346964ENST00000358186DLG1chr3197023217-BDH1chr3197241287-0.0026353210.9973647
ENST00000346964ENST00000441275DLG1chr3197023217-BDH1chr3197241287-0.0029679980.99703205
ENST00000419354ENST00000392379DLG1chr3197023217-BDH1chr3197241287-0.0028801880.9971198
ENST00000419354ENST00000392378DLG1chr3197023217-BDH1chr3197241287-0.0028801880.9971198
ENST00000419354ENST00000358186DLG1chr3197023217-BDH1chr3197241287-0.0028801880.9971198
ENST00000419354ENST00000441275DLG1chr3197023217-BDH1chr3197241287-0.004541440.9954586
ENST00000422288ENST00000392379DLG1chr3197023217-BDH1chr3197241287-0.0025371230.99746287
ENST00000422288ENST00000392378DLG1chr3197023217-BDH1chr3197241287-0.0025371230.99746287
ENST00000422288ENST00000358186DLG1chr3197023217-BDH1chr3197241287-0.0025371230.99746287
ENST00000422288ENST00000441275DLG1chr3197023217-BDH1chr3197241287-0.0044886410.9955114
ENST00000448528ENST00000392379DLG1chr3197023217-BDH1chr3197241287-0.0026353210.9973647
ENST00000448528ENST00000392378DLG1chr3197023217-BDH1chr3197241287-0.0026353210.9973647
ENST00000448528ENST00000358186DLG1chr3197023217-BDH1chr3197241287-0.0026353210.9973647
ENST00000448528ENST00000441275DLG1chr3197023217-BDH1chr3197241287-0.0029679980.99703205
ENST00000450955ENST00000392379DLG1chr3197023217-BDH1chr3197241287-0.0025371230.99746287
ENST00000450955ENST00000392378DLG1chr3197023217-BDH1chr3197241287-0.0025371230.99746287
ENST00000450955ENST00000358186DLG1chr3197023217-BDH1chr3197241287-0.0025371230.99746287
ENST00000450955ENST00000441275DLG1chr3197023217-BDH1chr3197241287-0.0044886410.9955114
ENST00000392382ENST00000392379DLG1chr3197023217-BDH1chr3197241287-0.0025809950.997419
ENST00000392382ENST00000392378DLG1chr3197023217-BDH1chr3197241287-0.0025809950.997419
ENST00000392382ENST00000358186DLG1chr3197023217-BDH1chr3197241287-0.0025809950.997419
ENST00000392382ENST00000441275DLG1chr3197023217-BDH1chr3197241287-0.003696760.9963032
ENST00000357674ENST00000358186DLG1chr3196817783-BDH1chr3197239235-0.0010336420.99896634
ENST00000314062ENST00000358186DLG1chr3196817783-BDH1chr3197239235-0.0010300590.9989699
ENST00000346964ENST00000358186DLG1chr3196817783-BDH1chr3197239235-0.0012539470.99874604
ENST00000419354ENST00000358186DLG1chr3196817783-BDH1chr3197239235-0.0012115080.99878854
ENST00000452595ENST00000358186DLG1chr3196817783-BDH1chr3197239235-0.0019316940.9980683
ENST00000422288ENST00000358186DLG1chr3196817783-BDH1chr3197239235-0.0012209210.9987791
ENST00000448528ENST00000358186DLG1chr3196817783-BDH1chr3197239235-0.0012539470.99874604
ENST00000443183ENST00000358186DLG1chr3196817783-BDH1chr3197239235-0.0020000670.99799997
ENST00000450955ENST00000358186DLG1chr3196817783-BDH1chr3197239235-0.001226020.998774
ENST00000392382ENST00000358186DLG1chr3196817783-BDH1chr3197239235-0.0011087930.9988912

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for DLG1-BDH1

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
DLG1chr3196817783BDH1chr31972392351462479GSLRTSQKRSLYVRPRRQYQQHAGPH
DLG1chr3196817783BDH1chr31972392351607535GSLRTSQKRSLYVRPRRQYQQHAGPH
DLG1chr3196817783BDH1chr31972392351661553GSLRTSQKRSLYVRPRRQYQQHAGPH
DLG1chr3196817783BDH1chr31972392351735479GSLRTSQKRSLYVRPRRQYQQHAGPH
DLG1chr3196817783BDH1chr31972392351735553GSLRTSQKRSLYVRPRRQYQQHAGPH
DLG1chr3196817783BDH1chr31972392351797535GSLRTSQKRSLYVRPRRQYQQHAGPH
DLG1chr3196817783BDH1chr31972392351851553GSLRTSQKRSLYVRPRRQYQQHAGPH
DLG1chr3196817783BDH1chr31972392351950586GSLRTSQKRSLYVRPRRQYQQHAGPH
DLG1chr3196817783BDH1chr31972392352047586GSLRTSQKRSLYVRPRRQYQQHAGPH
DLG1chr3197009549BDH1chr3197249652318106SETLPSSLSPSVEDKGHDGVKELDSL
DLG1chr3197009549BDH1chr3197249652392106SETLPSSLSPSVEDKGHDGVKELDSL
DLG1chr3197009549BDH1chr3197249652508106SETLPSSLSPSVEDKGHDGVKELDSL
DLG1chr3197009549BDH1chr3197249652605106SETLPSSLSPSVEDKGHDGVKELDSL
DLG1chr3197009550BDH1chr3197249652318106SETLPSSLSPSVEDKGHDGVKELDSL
DLG1chr3197009550BDH1chr3197249652392106SETLPSSLSPSVEDKGHDGVKELDSL
DLG1chr3197009550BDH1chr3197249652508106SETLPSSLSPSVEDKGHDGVKELDSL
DLG1chr3197009550BDH1chr3197249652605106SETLPSSLSPSVEDKGHDGVKELDSL
DLG1chr3197023216BDH1chr319724128715150INIFQSNLFQALIGMWGLVNNAGIST
DLG1chr3197023216BDH1chr319724128722550INIFQSNLFQALIGMWGLVNNAGIST
DLG1chr3197023216BDH1chr319724128734150INIFQSNLFQALIGMWGLVNNAGIST
DLG1chr3197023216BDH1chr319724128743850INIFQSNLFQALIGMWGLVNNAGIST
DLG1chr3197023217BDH1chr319724128715150INIFQSNLFQALIGMWGLVNNAGIST
DLG1chr3197023217BDH1chr319724128722550INIFQSNLFQALIGMWGLVNNAGIST
DLG1chr3197023217BDH1chr319724128734150INIFQSNLFQALIGMWGLVNNAGIST
DLG1chr3197023217BDH1chr319724128743850INIFQSNLFQALIGMWGLVNNAGIST

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Potential FusionNeoAntigen Information of DLG1-BDH1 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
DLG1-BDH1_196817783_197239235.msa
DLG1-BDH1_197009549_197249652.msa
DLG1-BDH1_197023216_197241287.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
DLG1-BDH1chr3196817783chr31972392351797HLA-B27:05KRSLYVRPR0.99910.8845716
DLG1-BDH1chr3196817783chr31972392351797HLA-A74:11RSLYVRPRR0.99110.6817
DLG1-BDH1chr3196817783chr31972392351797HLA-A74:03RSLYVRPRR0.99110.6817
DLG1-BDH1chr3196817783chr31972392351797HLA-A74:09RSLYVRPRR0.99110.6817
DLG1-BDH1chr3196817783chr31972392351797HLA-A30:08RSLYVRPRR0.9520.7367817
DLG1-BDH1chr3196817783chr31972392351797HLA-A74:11RTSQKRSLYVR0.99690.511314
DLG1-BDH1chr3196817783chr31972392351797HLA-A74:03RTSQKRSLYVR0.99690.511314
DLG1-BDH1chr3196817783chr31972392351797HLA-A74:09RTSQKRSLYVR0.99690.511314
DLG1-BDH1chr3196817783chr31972392351797HLA-C07:80LYVRPRRQY0.09250.7831019
DLG1-BDH1chr3196817783chr31972392351797HLA-C07:67LYVRPRRQY0.09250.7831019
DLG1-BDH1chr3196817783chr31972392351797HLA-C07:10LYVRPRRQY0.07990.83661019
DLG1-BDH1chr3196817783chr31972392351797HLA-C07:46LYVRPRRQY0.06840.63331019
DLG1-BDH1chr3196817783chr31972392351797HLA-C07:27LYVRPRRQY0.05950.84211019
DLG1-BDH1chr3196817783chr31972392351797HLA-C12:16LYVRPRRQY0.02180.90961019
DLG1-BDH1chr3196817783chr31972392351797HLA-C07:05LYVRPRRQY0.01870.87381019
DLG1-BDH1chr3196817783chr31972392351797HLA-B15:04SLYVRPRRQY0.84110.8141919
DLG1-BDH1chr3196817783chr31972392351797HLA-C12:03YVRPRRQY0.78790.95251119
DLG1-BDH1chr3196817783chr31972392351797HLA-B27:10KRSLYVRPR0.99820.8889716
DLG1-BDH1chr3196817783chr31972392351797HLA-A74:01RSLYVRPRR0.99110.6817
DLG1-BDH1chr3196817783chr31972392351797HLA-A30:01RSLYVRPRR0.96280.8909817
DLG1-BDH1chr3196817783chr31972392351797HLA-C07:17LYVRPRRQY0.1060.91051019
DLG1-BDH1chr3196817783chr31972392351797HLA-C07:02LYVRPRRQY0.09250.7831019
DLG1-BDH1chr3196817783chr31972392351797HLA-C06:06LYVRPRRQY0.00150.97061019
DLG1-BDH1chr3196817783chr31972392351797HLA-C14:02LYVRPRRQY0.00080.90811019
DLG1-BDH1chr3196817783chr31972392351797HLA-C14:03LYVRPRRQY0.00080.90811019
DLG1-BDH1chr3196817783chr31972392351797HLA-B15:35SLYVRPRRQY0.9710.7737919
DLG1-BDH1chr3196817783chr31972392351797HLA-A74:01RTSQKRSLYVR0.99690.511314
DLG1-BDH1chr3196817783chr31972392351797HLA-B58:06RSLYVRPRRQY0.97480.7476819
DLG1-BDH1chr3197009549chr3197249652508HLA-B41:01VEDKGHDGV0.24780.74541120
DLG1-BDH1chr3197009549chr3197249652508HLA-A30:08SSLSPSVEDK0.83340.6035515
DLG1-BDH1chr3197009549chr3197249652508HLA-B39:08VEDKGHDGV0.25330.68971120
DLG1-BDH1chr3197009549chr3197249652508HLA-B41:03VEDKGHDGV0.10270.56391120
DLG1-BDH1chr3197009549chr3197249652508HLA-A30:01SSLSPSVEDK0.82370.7377515
DLG1-BDH1chr3197023216chr3197241287341HLA-A02:04NLFQALIGM0.71840.851615
DLG1-BDH1chr3197023216chr3197241287341HLA-A02:17NLFQALIGM0.69410.6769615
DLG1-BDH1chr3197023216chr3197241287341HLA-B15:24FQALIGMW0.99620.9866816

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Potential FusionNeoAntigen Information of DLG1-BDH1 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
DLG1-BDH1_196817783_197239235.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
DLG1-BDH1chr3196817783chr31972392351797DRB1-1102KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1102QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1102SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1102RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1103KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1103QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1114KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1114QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1116KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1116QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1116SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1116RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1120KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1120QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1121KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1121QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1121SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1121RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1136KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1136QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1148KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1155KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1155QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1159KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1163KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1163QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1165KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1165QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1165SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1165RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1168KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1170KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1170QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1170SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1170RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1176KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1176QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1185KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1185QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1186KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1186QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1301KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1301QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1301SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1301RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1302KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1302QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1304KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1304QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1304SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1308KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1315KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1315QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1315SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1315RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1316KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1316QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1317KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1317QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1319KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1319QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1320KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1320QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1322KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1322QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1322SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1322RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1323KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1323QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1324KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1324QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1327KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1327QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1327SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1329KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1332KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1334KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1334QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1335KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1335QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1335SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1335RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1339KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1339QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1341KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1343KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1343QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1343SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1348KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1351KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1351QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1351SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1351RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1352KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1352QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1352SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1352RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1353KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1353QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1354KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1354QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1357KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1357QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1357SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1357RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1359KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1359QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1359SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1359RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1361KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1361QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1361SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1361RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1364KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1364QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1364SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1364RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1368KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1368QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1368SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1368RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1369KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1369QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1369SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1369RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1370KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1371KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1371QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1372KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1373KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1373QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1374KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1374QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1375KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1375QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1378KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1378QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1379KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1379QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1379SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1379RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1380KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1380QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1380SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1380RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1383KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1383QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1383SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1383RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1384KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1387KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1387QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1387SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1387RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1391KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1391QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1391SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1391RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1392KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1392QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1392SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1392RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1393KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1393QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1393SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1396KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1397KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1397QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1398KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1398QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1398SQKRSLYVRPRRQYQ520
DLG1-BDH1chr3196817783chr31972392351797DRB1-1398RSLYVRPRRQYQQHA823
DLG1-BDH1chr3196817783chr31972392351797DRB1-1399KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1399QKRSLYVRPRRQYQQ621
DLG1-BDH1chr3196817783chr31972392351797DRB1-1416KRSLYVRPRRQYQQH722
DLG1-BDH1chr3196817783chr31972392351797DRB1-1416QKRSLYVRPRRQYQQ621

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Fusion breakpoint peptide structures of DLG1-BDH1

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
6247NLFQALIGMWGLVNDLG1BDH1chr3197023216chr3197241287341
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
7360QKRSLYVRPRRQYQDLG1BDH1chr3196817783chr31972392351797
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
8795SLSPSVEDKGHDGVDLG1BDH1chr3197009549chr3197249652508

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of DLG1-BDH1

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN6247NLFQALIGMWGLVN-7.9962-8.1096
HLA-B14:023BVN6247NLFQALIGMWGLVN-5.70842-6.74372
HLA-B52:013W396247NLFQALIGMWGLVN-6.83737-6.95077
HLA-B52:013W396247NLFQALIGMWGLVN-4.4836-5.5189
HLA-A11:014UQ26247NLFQALIGMWGLVN-10.0067-10.1201
HLA-A11:014UQ26247NLFQALIGMWGLVN-9.03915-10.0745
HLA-A24:025HGA6247NLFQALIGMWGLVN-6.56204-6.67544
HLA-A24:025HGA6247NLFQALIGMWGLVN-5.42271-6.45801
HLA-B44:053DX86247NLFQALIGMWGLVN-7.85648-8.89178
HLA-B44:053DX86247NLFQALIGMWGLVN-5.3978-5.5112
HLA-A02:016TDR6247NLFQALIGMWGLVN-3.37154-4.40684
HLA-B14:023BVN7360QKRSLYVRPRRQYQ-7.15543-7.26883
HLA-B14:023BVN7360QKRSLYVRPRRQYQ-4.77435-5.80965
HLA-B52:013W397360QKRSLYVRPRRQYQ-6.80875-6.92215
HLA-B52:013W397360QKRSLYVRPRRQYQ-4.20386-5.23916
HLA-A11:014UQ27360QKRSLYVRPRRQYQ-7.5194-8.5547
HLA-A11:014UQ27360QKRSLYVRPRRQYQ-6.9601-7.0735
HLA-A24:025HGA7360QKRSLYVRPRRQYQ-7.52403-7.63743
HLA-A24:025HGA7360QKRSLYVRPRRQYQ-5.82433-6.85963
HLA-B27:056PYJ7360QKRSLYVRPRRQYQ-3.28285-4.31815
HLA-B44:053DX87360QKRSLYVRPRRQYQ-5.91172-6.94702
HLA-B44:053DX87360QKRSLYVRPRRQYQ-4.24346-4.35686
HLA-B14:023BVN8795SLSPSVEDKGHDGV-7.15543-7.26883
HLA-B14:023BVN8795SLSPSVEDKGHDGV-4.77435-5.80965
HLA-B52:013W398795SLSPSVEDKGHDGV-6.80875-6.92215
HLA-B52:013W398795SLSPSVEDKGHDGV-4.20386-5.23916
HLA-A11:014UQ28795SLSPSVEDKGHDGV-7.5194-8.5547
HLA-A11:014UQ28795SLSPSVEDKGHDGV-6.9601-7.0735
HLA-A24:025HGA8795SLSPSVEDKGHDGV-7.52403-7.63743
HLA-A24:025HGA8795SLSPSVEDKGHDGV-5.82433-6.85963
HLA-B27:056PYJ8795SLSPSVEDKGHDGV-3.28285-4.31815
HLA-B44:053DX88795SLSPSVEDKGHDGV-5.91172-6.94702
HLA-B44:053DX88795SLSPSVEDKGHDGV-4.24346-4.35686

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Vaccine Design for the FusionNeoAntigens of DLG1-BDH1

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
DLG1-BDH1chr3196817783chr31972392351019LYVRPRRQYCTATGTCAGGCCGCGTCGTCAATATCA
DLG1-BDH1chr3196817783chr31972392351119YVRPRRQYTGTCAGGCCGCGTCGTCAATATCA
DLG1-BDH1chr3196817783chr3197239235314RTSQKRSLYVRAACTAGCCAGAAGCGATCCCTCTATGTCAGGCC
DLG1-BDH1chr3196817783chr3197239235716KRSLYVRPRGCGATCCCTCTATGTCAGGCCGCGTCG
DLG1-BDH1chr3196817783chr3197239235817RSLYVRPRRATCCCTCTATGTCAGGCCGCGTCGTCA
DLG1-BDH1chr3196817783chr3197239235819RSLYVRPRRQYATCCCTCTATGTCAGGCCGCGTCGTCAATATCA
DLG1-BDH1chr3196817783chr3197239235919SLYVRPRRQYCCTCTATGTCAGGCCGCGTCGTCAATATCA
DLG1-BDH1chr3197009549chr31972496521120VEDKGHDGVGTAGAGGACAAAGGCCATGATGGGGTC
DLG1-BDH1chr3197009549chr3197249652515SSLSPSVEDKAGCAGCCTTAGCCCTAGTGTAGAGGACAAA
DLG1-BDH1chr3197023216chr3197241287615NLFQALIGMACCTCTTTCAGGCTTTAATAGGCATGT
DLG1-BDH1chr3197023216chr3197241287816FQALIGMWTTCAGGCTTTAATAGGCATGTGGG

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
DLG1-BDH1chr3196817783chr3197239235520SQKRSLYVRPRRQYQCCAGAAGCGATCCCTCTATGTCAGGCCGCGTCGTCAATATCAGCA
DLG1-BDH1chr3196817783chr3197239235621QKRSLYVRPRRQYQQGAAGCGATCCCTCTATGTCAGGCCGCGTCGTCAATATCAGCAGCA
DLG1-BDH1chr3196817783chr3197239235722KRSLYVRPRRQYQQHGCGATCCCTCTATGTCAGGCCGCGTCGTCAATATCAGCAGCATGC
DLG1-BDH1chr3196817783chr3197239235823RSLYVRPRRQYQQHAATCCCTCTATGTCAGGCCGCGTCGTCAATATCAGCAGCATGCTGG

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Information of the samples that have these potential fusion neoantigens of DLG1-BDH1

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
CESCDLG1-BDH1chr3196817783ENST00000314062chr3197239235ENST00000358186TCGA-VS-A959-01A
ESCADLG1-BDH1chr3197009549ENST00000314062chr3197249652ENST00000358186TCGA-L5-A4OS
HNSCDLG1-BDH1chr3197023216ENST00000314062chr3197241287ENST00000358186TCGA-P3-A5QA

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Potential target of CAR-T therapy development for DLG1-BDH1

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to DLG1-BDH1

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DLG1-BDH1

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource