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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:DNAJC3-BAZ1B

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DNAJC3-BAZ1B
FusionPDB ID: 23533
FusionGDB2.0 ID: 23533
HgeneTgene
Gene symbol

DNAJC3

BAZ1B

Gene ID

5611

9031

Gene nameDnaJ heat shock protein family (Hsp40) member C3bromodomain adjacent to zinc finger domain 1B
SynonymsACPHD|ERdj6|HP58|P58|P58IPK|PRKRI|p58(IPK)WBSCR10|WBSCR9|WSTF
Cytomap

13q32.1

7q11.23

Type of geneprotein-codingprotein-coding
DescriptiondnaJ homolog subfamily C member 3DnaJ (Hsp40) homolog, subfamily C, member 3ER-resident protein ERdj6endoplasmic reticulum DNA J domain-containing protein 6interferon-induced, double-stranded RNA-activated protein kinase inhibitorprotein kinase inhibtyrosine-protein kinase BAZ1BhWALp2transcription factor WSTFwilliams syndrome transcription factorwilliams-Beuren syndrome chromosomal region 10 proteinwilliams-Beuren syndrome chromosomal region 9 protein
Modification date2020032920200313
UniProtAcc

Q13217

Main function of 5'-partner protein: FUNCTION: Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. {ECO:0000250|UniProtKB:Q27968, ECO:0000250|UniProtKB:Q91YW3, ECO:0000269|PubMed:12601012, ECO:0000269|PubMed:8576172, ECO:0000269|PubMed:9447982, ECO:0000269|PubMed:9920933}.

Q9UIG0

Main function of 5'-partner protein: FUNCTION: Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. {ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442}.
Ensembl transtripts involved in fusion geneENST idsENST00000376795, ENST00000602402, 
ENST00000339594, ENST00000404251, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 14 X 8=168010 X 11 X 5=550
# samples 1813
** MAII scorelog2(18/1680*10)=-3.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/550*10)=-2.08091999538357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: DNAJC3 [Title/Abstract] AND BAZ1B [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: DNAJC3 [Title/Abstract] AND BAZ1B [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DNAJC3(96361591)-BAZ1B(72884813), # samples:1
Anticipated loss of major functional domain due to fusion event.DNAJC3-BAZ1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNAJC3-BAZ1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNAJC3-BAZ1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DNAJC3-BAZ1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBAZ1B

GO:0006974

cellular response to DNA damage stimulus

19092802

TgeneBAZ1B

GO:0016572

histone phosphorylation

19092802



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:96361591/chr7:72884813)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across DNAJC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BAZ1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000602402DNAJC3chr1396361591+ENST00000339594BAZ1Bchr772884813-3480310452168707
ENST00000602402DNAJC3chr1396361591+ENST00000404251BAZ1Bchr772884813-2800310452168707
ENST00000376795DNAJC3chr1396361591+ENST00000339594BAZ1Bchr772884813-3461291262149707
ENST00000376795DNAJC3chr1396361591+ENST00000404251BAZ1Bchr772884813-2781291262149707

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000602402ENST00000339594DNAJC3chr1396361591+BAZ1Bchr772884813-0.0020556550.9979443
ENST00000602402ENST00000404251DNAJC3chr1396361591+BAZ1Bchr772884813-0.0031219640.996878
ENST00000376795ENST00000339594DNAJC3chr1396361591+BAZ1Bchr772884813-0.0019811160.99801886
ENST00000376795ENST00000404251DNAJC3chr1396361591+BAZ1Bchr772884813-0.0030138070.9969862

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for DNAJC3-BAZ1B

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
DNAJC3chr1396361591BAZ1Bchr77288481329188QLADALSQFHAAVVKLERQAEEERIR
DNAJC3chr1396361591BAZ1Bchr77288481331088QLADALSQFHAAVVKLERQAEEERIR

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Potential FusionNeoAntigen Information of DNAJC3-BAZ1B in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
DNAJC3-BAZ1B_96361591_72884813.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B39:06FHAAVVKL0.99970.7575816
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B39:01FHAAVVKL0.99950.9018816
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B38:01FHAAVVKL0.99910.9367816
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B38:02FHAAVVKL0.99910.9365816
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B15:10FHAAVVKL0.99850.6249816
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B13:02SQFHAAVV0.99590.8858614
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B14:02FHAAVVKL0.99560.8356816
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B14:01FHAAVVKL0.99560.8356816
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B15:18FHAAVVKL0.98590.7792816
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B15:37FHAAVVKL0.95710.563816
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B52:01SQFHAAVV0.92670.9891614
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-A30:08SQFHAAVVK0.97960.6503615
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-A31:02HAAVVKLER0.93170.5537918
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-A31:06HAAVVKLER0.90250.5741918
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B48:01SQFHAAVVKL0.95570.5005616
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B13:02SQFHAAVVKL0.77030.7233616
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B13:01SQFHAAVVKL0.65770.9546616
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B39:09FHAAVVKL0.99960.7574816
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B39:12FHAAVVKL0.99930.9004816
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B39:05FHAAVVKL0.99890.8769816
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-C07:13FHAAVVKL0.9790.8626816
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-C07:29FHAAVVKL0.97840.9279816
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-C12:16FHAAVVKL0.8960.9833816
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B51:07SQFHAAVV0.84780.978614
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B14:03FHAAVVKL0.72620.8941816
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-A31:01HAAVVKLER0.9730.556918
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B15:04SQFHAAVVK0.51260.7457615
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-C07:29QFHAAVVKL0.33150.9376716
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-C07:13QFHAAVVKL0.31360.9588716
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-C04:14QFHAAVVKL0.2890.9301716
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B15:04SQFHAAVVKL0.99370.8401616
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B39:31FHAAVVKL0.99940.9013816
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B38:05FHAAVVKL0.99910.9367816
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B15:09FHAAVVKL0.99570.8561816
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B39:11FHAAVVKL0.96140.9062816
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-A30:01SQFHAAVVK0.97730.7876615
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-C03:67QFHAAVVKL0.39440.9802716
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-C04:04QFHAAVVKL0.23740.8998716
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-C14:03QFHAAVVKL0.1120.9782716
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-C14:02QFHAAVVKL0.1120.9782716
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-C06:06QFHAAVVKL0.0520.992716
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B15:73SQFHAAVVKL0.98680.9266616
DNAJC3-BAZ1Bchr1396361591chr772884813291HLA-B15:30SQFHAAVVKL0.95950.8605616

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Potential FusionNeoAntigen Information of DNAJC3-BAZ1B in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
DNAJC3-BAZ1B_96361591_72884813.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0417LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0417ALSQFHAAVVKLERQ419
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0424LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0447LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0454LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0469LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0469ALSQFHAAVVKLERQ419
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0480LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0486LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0486ALSQFHAAVVKLERQ419
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0486SQFHAAVVKLERQAE621
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0801HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0801FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0803LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0803HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0804HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0805HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0805FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0806HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0806FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0806QFHAAVVKLERQAEE722
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0806AAVVKLERQAEEERI1025
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0808HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0810HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0810FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0810QFHAAVVKLERQAEE722
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0810AAVVKLERQAEEERI1025
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0811HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0812HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0812FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0812QFHAAVVKLERQAEE722
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0812AAVVKLERQAEEERI1025
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0814LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0814HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0816HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0816FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0818HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0818FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0820HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0822HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0822FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0822QFHAAVVKLERQAEE722
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0822AAVVKLERQAEEERI1025
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0823LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0823HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0826HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0826FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0827LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0827HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0828HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0829LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0829HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0829ALSQFHAAVVKLERQ419
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0831HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0831FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0832LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0832HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0833LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0833HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0835LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0835HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0836LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0836HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0837HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0838LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0838HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0839HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0839FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0840HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0840FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0901LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0901ALSQFHAAVVKLERQ419
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0901SQFHAAVVKLERQAE621
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0901DALSQFHAAVVKLER318
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0902LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0902ALSQFHAAVVKLERQ419
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0902SQFHAAVVKLERQAE621
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0902DALSQFHAAVVKLER318
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0903LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0903ALSQFHAAVVKLERQ419
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0903SQFHAAVVKLERQAE621
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0903DALSQFHAAVVKLER318
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0904LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0904ALSQFHAAVVKLERQ419
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0904SQFHAAVVKLERQAE621
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0904DALSQFHAAVVKLER318
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0905LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0905ALSQFHAAVVKLERQ419
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0907LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0907ALSQFHAAVVKLERQ419
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0907SQFHAAVVKLERQAE621
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0908LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0908ALSQFHAAVVKLERQ419
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0908SQFHAAVVKLERQAE621
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0908DALSQFHAAVVKLER318
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0909LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0909ALSQFHAAVVKLERQ419
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0909SQFHAAVVKLERQAE621
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-0909DALSQFHAAVVKLER318
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1104HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1104FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1106HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1106FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1113HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1118HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1118FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1125HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1134HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1134FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1135HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1135FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1138HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1138FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1141HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1142HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1142FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1143HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1143FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1144HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1144FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1146HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1146FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1147HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1147FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1150HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1150FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1154HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1154FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1156HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1156FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1157HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1157FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1158HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1158FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1159HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1160HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1160FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1167HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1177HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1177FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1178HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1178FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1183HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1183FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1184HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1188HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1188FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1192HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1192FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1204HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1204FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1209HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1209FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1220HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1303HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1303FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1304HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1304FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1306HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1306FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1309HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-13101HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-13101FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1310HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1310FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1311HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1311FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1312HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1312FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1312QFHAAVVKLERQAEE722
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1313HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1313FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1318HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1321HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1321FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1321QFHAAVVKLERQAEE722
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1330HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1330FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1332HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1332FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1332QFHAAVVKLERQAEE722
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1332AAVVKLERQAEEERI1025
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1338HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1338FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1342HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1342FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1343HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1344HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1344FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1348HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1348FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1348QFHAAVVKLERQAEE722
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1348AAVVKLERQAEEERI1025
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1349HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1349FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1355HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1355FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1358HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1358FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1358QFHAAVVKLERQAEE722
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1358AAVVKLERQAEEERI1025
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1365HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1365FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1366HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1366FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1375HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1375FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1375AAVVKLERQAEEERI1025
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1375QFHAAVVKLERQAEE722
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1377HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1377FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1381HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1381FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1381QFHAAVVKLERQAEE722
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1381AAVVKLERQAEEERI1025
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1388HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1388FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1389HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1389FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1389QFHAAVVKLERQAEE722
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1389AAVVKLERQAEEERI1025
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1390HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1390FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1393HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1393FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1394HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1394FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1394AAVVKLERQAEEERI1025
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1394QFHAAVVKLERQAEE722
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1395HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1395FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1406HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1412HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1413HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1413FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1415HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1416HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1417HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1417FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1420HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1421HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1422HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1422FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1425HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1425FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1429HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1431HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1432HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1433HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1433FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1434HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1437HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1452HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1453HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1453FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1463HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1463LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1465HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1465FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1465QFHAAVVKLERQAEE722
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1465AAVVKLERQAEEERI1025
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1469HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1469FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1473HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1473FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1474HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1474FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1474QFHAAVVKLERQAEE722
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1474AAVVKLERQAEEERI1025
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1478HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1478FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1478AAVVKLERQAEEERI1025
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1478QFHAAVVKLERQAEE722
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1480HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1480FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1483HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1484HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1484FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1485HAAVVKLERQAEEER924
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1485FHAAVVKLERQAEEE823
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB1-1521ADALSQFHAAVVKLE217
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB5-0112LSQFHAAVVKLERQA520
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB5-0112ALSQFHAAVVKLERQ419
DNAJC3-BAZ1Bchr1396361591chr772884813291DRB5-0112SQFHAAVVKLERQAE621

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Fusion breakpoint peptide structures of DNAJC3-BAZ1B

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
8916SQFHAAVVKLERQADNAJC3BAZ1Bchr1396361591chr772884813291

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of DNAJC3-BAZ1B

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN8916SQFHAAVVKLERQA-7.9962-8.1096
HLA-B14:023BVN8916SQFHAAVVKLERQA-5.70842-6.74372
HLA-B52:013W398916SQFHAAVVKLERQA-6.83737-6.95077
HLA-B52:013W398916SQFHAAVVKLERQA-4.4836-5.5189
HLA-A11:014UQ28916SQFHAAVVKLERQA-10.0067-10.1201
HLA-A11:014UQ28916SQFHAAVVKLERQA-9.03915-10.0745
HLA-A24:025HGA8916SQFHAAVVKLERQA-6.56204-6.67544
HLA-A24:025HGA8916SQFHAAVVKLERQA-5.42271-6.45801
HLA-B44:053DX88916SQFHAAVVKLERQA-7.85648-8.89178
HLA-B44:053DX88916SQFHAAVVKLERQA-5.3978-5.5112
HLA-A02:016TDR8916SQFHAAVVKLERQA-3.37154-4.40684

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Vaccine Design for the FusionNeoAntigens of DNAJC3-BAZ1B

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
DNAJC3-BAZ1Bchr1396361591chr772884813614SQFHAAVVCTCAGTTTCATGCTGCCGTAGTGA
DNAJC3-BAZ1Bchr1396361591chr772884813615SQFHAAVVKCTCAGTTTCATGCTGCCGTAGTGAAAC
DNAJC3-BAZ1Bchr1396361591chr772884813616SQFHAAVVKLCTCAGTTTCATGCTGCCGTAGTGAAACTGG
DNAJC3-BAZ1Bchr1396361591chr772884813716QFHAAVVKLAGTTTCATGCTGCCGTAGTGAAACTGG
DNAJC3-BAZ1Bchr1396361591chr772884813816FHAAVVKLTTCATGCTGCCGTAGTGAAACTGG
DNAJC3-BAZ1Bchr1396361591chr772884813918HAAVVKLERATGCTGCCGTAGTGAAACTGGAACGCC

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
DNAJC3-BAZ1Bchr1396361591chr7728848131025AAVVKLERQAEEERICTGCCGTAGTGAAACTGGAACGCCAAGCTGAAGAAGAACGAATAC
DNAJC3-BAZ1Bchr1396361591chr772884813217ADALSQFHAAVVKLECTGATGCTTTATCTCAGTTTCATGCTGCCGTAGTGAAACTGGAAC
DNAJC3-BAZ1Bchr1396361591chr772884813318DALSQFHAAVVKLERATGCTTTATCTCAGTTTCATGCTGCCGTAGTGAAACTGGAACGCC
DNAJC3-BAZ1Bchr1396361591chr772884813419ALSQFHAAVVKLERQCTTTATCTCAGTTTCATGCTGCCGTAGTGAAACTGGAACGCCAAG
DNAJC3-BAZ1Bchr1396361591chr772884813520LSQFHAAVVKLERQATATCTCAGTTTCATGCTGCCGTAGTGAAACTGGAACGCCAAGCTG
DNAJC3-BAZ1Bchr1396361591chr772884813621SQFHAAVVKLERQAECTCAGTTTCATGCTGCCGTAGTGAAACTGGAACGCCAAGCTGAAG
DNAJC3-BAZ1Bchr1396361591chr772884813722QFHAAVVKLERQAEEAGTTTCATGCTGCCGTAGTGAAACTGGAACGCCAAGCTGAAGAAG
DNAJC3-BAZ1Bchr1396361591chr772884813823FHAAVVKLERQAEEETTCATGCTGCCGTAGTGAAACTGGAACGCCAAGCTGAAGAAGAAC
DNAJC3-BAZ1Bchr1396361591chr772884813924HAAVVKLERQAEEERATGCTGCCGTAGTGAAACTGGAACGCCAAGCTGAAGAAGAACGAA

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Information of the samples that have these potential fusion neoantigens of DNAJC3-BAZ1B

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
OVDNAJC3-BAZ1Bchr1396361591ENST00000376795chr772884813ENST00000339594TCGA-04-1514

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Potential target of CAR-T therapy development for DNAJC3-BAZ1B

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to DNAJC3-BAZ1B

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DNAJC3-BAZ1B

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource