Home

Download

Statistics

Examples

Help

Contact

Fusion Protein:ADK-KAT6B

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ADK-KAT6B
	FusionPDB ID: 2468
	FusionGDB2.0 ID: 2468
		Hgene	Tgene
	Gene symbol	ADK	KAT6B
	Gene ID	132	23522
	Gene name	adenosine kinase	lysine acetyltransferase 6B
	Synonyms	AK	GTPTS\|MORF\|MOZ2\|MYST4\|ZC2HC6B\|qkf\|querkopf
	Cytomap	10q22.2\|10q11-q24	10q22.2
	Type of gene	protein-coding	protein-coding
	Description	adenosine kinaseadenosine 5'-phosphotransferasetesticular tissue protein Li 14	histone acetyltransferase KAT6BK(lysine) acetyltransferase 6BMOZ, YBF2/SAS3, SAS2 and TIP60 protein 4MOZ-related factorMYST histone acetyltransferase (monocytic leukemia) 4MYST-4histone acetyltransferase MORFhistone acetyltransferase MOZ2histone a
	Modification date	20200313	20200313
	UniProtAcc	P55263 Main function of 5'-partner protein: FUNCTION: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.	Q8WYB5 Main function of 5'-partner protein: FUNCTION: Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269\|PubMed:10497217, ECO:0000269\|PubMed:11965546, ECO:0000269\|PubMed:16387653}.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000286621, ENST00000372734, ENST00000539909, ENST00000541550, ENST00000467840,	ENST00000287239, ENST00000372724, ENST00000372711, ENST00000372714, ENST00000372725, ENST00000490365,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	19 X 13 X 10=2470	7 X 11 X 4=308
	# samples	26	10
	** MAII score	log2(26/2470*10)=-3.24792751344359 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/308*10)=-1.62293035092018 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: ADK [Title/Abstract] AND KAT6B [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: ADK [Title/Abstract] AND KAT6B [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	KAT6B(76603236)-ADK(76349040), # samples:6 ADK(76074503)-KAT6B(76719728), # samples:2
Anticipated loss of major functional domain due to fusion event.	ADK-KAT6B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADK-KAT6B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADK-KAT6B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ADK-KAT6B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KAT6B-ADK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KAT6B-ADK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KAT6B-ADK seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. KAT6B-ADK seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. KAT6B-ADK seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. KAT6B-ADK seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. KAT6B-ADK seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. KAT6B-ADK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	KAT6B	GO:0016573	histone acetylation	11965546
Tgene	KAT6B	GO:0043966	histone H3 acetylation	16387653
Tgene	KAT6B	GO:0045892	negative regulation of transcription, DNA-templated	10497217
Tgene	KAT6B	GO:0045893	positive regulation of transcription, DNA-templated	10497217\|11965546

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:76603236/chr10:76349040)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across ADK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KAT6B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000539909	ADK	chr10	76074503	+	ENST00000372725	KAT6B	chr10	76719728	+	6322	350	77	5074	1665
ENST00000539909	ADK	chr10	76074503	+	ENST00000372724	KAT6B	chr10	76719728	+	6321	350	77	5074	1665
ENST00000539909	ADK	chr10	76074503	+	ENST00000287239	KAT6B	chr10	76719728	+	7527	350	77	5950	1957
ENST00000539909	ADK	chr10	76074503	+	ENST00000372714	KAT6B	chr10	76719728	+	5219	350	77	5074	1665
ENST00000539909	ADK	chr10	76074503	+	ENST00000372711	KAT6B	chr10	76719728	+	6978	350	77	5401	1774
ENST00000286621	ADK	chr10	76074503	+	ENST00000372725	KAT6B	chr10	76719728	+	6295	323	50	5047	1665
ENST00000286621	ADK	chr10	76074503	+	ENST00000372724	KAT6B	chr10	76719728	+	6294	323	50	5047	1665
ENST00000286621	ADK	chr10	76074503	+	ENST00000287239	KAT6B	chr10	76719728	+	7500	323	50	5923	1957
ENST00000286621	ADK	chr10	76074503	+	ENST00000372714	KAT6B	chr10	76719728	+	5192	323	50	5047	1665
ENST00000286621	ADK	chr10	76074503	+	ENST00000372711	KAT6B	chr10	76719728	+	6951	323	50	5374	1774
ENST00000372734	ADK	chr10	76074503	+	ENST00000372725	KAT6B	chr10	76719728	+	6381	409	187	5133	1648
ENST00000372734	ADK	chr10	76074503	+	ENST00000372724	KAT6B	chr10	76719728	+	6380	409	187	5133	1648
ENST00000372734	ADK	chr10	76074503	+	ENST00000287239	KAT6B	chr10	76719728	+	7586	409	187	6009	1940
ENST00000372734	ADK	chr10	76074503	+	ENST00000372714	KAT6B	chr10	76719728	+	5278	409	187	5133	1648
ENST00000372734	ADK	chr10	76074503	+	ENST00000372711	KAT6B	chr10	76719728	+	7037	409	187	5460	1757
ENST00000541550	ADK	chr10	76074503	+	ENST00000372725	KAT6B	chr10	76719728	+	6250	278	110	5002	1630
ENST00000541550	ADK	chr10	76074503	+	ENST00000372724	KAT6B	chr10	76719728	+	6249	278	110	5002	1630
ENST00000541550	ADK	chr10	76074503	+	ENST00000287239	KAT6B	chr10	76719728	+	7455	278	110	5878	1922
ENST00000541550	ADK	chr10	76074503	+	ENST00000372714	KAT6B	chr10	76719728	+	5147	278	110	5002	1630
ENST00000541550	ADK	chr10	76074503	+	ENST00000372711	KAT6B	chr10	76719728	+	6906	278	110	5329	1739

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000539909	ENST00000372725	ADK	chr10	76074503	+	KAT6B	chr10	76719728	+	0.000859756	0.99914026
ENST00000539909	ENST00000372724	ADK	chr10	76074503	+	KAT6B	chr10	76719728	+	0.000867901	0.9991321
ENST00000539909	ENST00000287239	ADK	chr10	76074503	+	KAT6B	chr10	76719728	+	0.000594304	0.99940574
ENST00000539909	ENST00000372714	ADK	chr10	76074503	+	KAT6B	chr10	76719728	+	0.00270239	0.9972976
ENST00000539909	ENST00000372711	ADK	chr10	76074503	+	KAT6B	chr10	76719728	+	0.000597228	0.99940276
ENST00000286621	ENST00000372725	ADK	chr10	76074503	+	KAT6B	chr10	76719728	+	0.000830194	0.9991698
ENST00000286621	ENST00000372724	ADK	chr10	76074503	+	KAT6B	chr10	76719728	+	0.000838327	0.9991617
ENST00000286621	ENST00000287239	ADK	chr10	76074503	+	KAT6B	chr10	76719728	+	0.000574076	0.999426
ENST00000286621	ENST00000372714	ADK	chr10	76074503	+	KAT6B	chr10	76719728	+	0.002657803	0.99734217
ENST00000286621	ENST00000372711	ADK	chr10	76074503	+	KAT6B	chr10	76719728	+	0.000578203	0.99942183
ENST00000372734	ENST00000372725	ADK	chr10	76074503	+	KAT6B	chr10	76719728	+	0.000967686	0.9990324
ENST00000372734	ENST00000372724	ADK	chr10	76074503	+	KAT6B	chr10	76719728	+	0.000976891	0.9990231
ENST00000372734	ENST00000287239	ADK	chr10	76074503	+	KAT6B	chr10	76719728	+	0.000668161	0.9993318
ENST00000372734	ENST00000372714	ADK	chr10	76074503	+	KAT6B	chr10	76719728	+	0.003057118	0.9969428
ENST00000372734	ENST00000372711	ADK	chr10	76074503	+	KAT6B	chr10	76719728	+	0.000670066	0.9993299
ENST00000541550	ENST00000372725	ADK	chr10	76074503	+	KAT6B	chr10	76719728	+	0.000862701	0.9991373
ENST00000541550	ENST00000372724	ADK	chr10	76074503	+	KAT6B	chr10	76719728	+	0.000870667	0.99912935
ENST00000541550	ENST00000287239	ADK	chr10	76074503	+	KAT6B	chr10	76719728	+	0.000595051	0.9994049
ENST00000541550	ENST00000372714	ADK	chr10	76074503	+	KAT6B	chr10	76719728	+	0.002805825	0.9971942
ENST00000541550	ENST00000372711	ADK	chr10	76074503	+	KAT6B	chr10	76719728	+	0.000594363	0.9994056

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

Top

Fusion Protein Breakpoint Sequences for ADK-KAT6B

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
ADK	chr10	76074503	KAT6B	chr10	76719728	278	30	DISAVVDKDFLDKFDELVKKFKVEYH
ADK	chr10	76074503	KAT6B	chr10	76719728	323	65	NDQILAEDKHKELFDELVKKFKVEYH
ADK	chr10	76074503	KAT6B	chr10	76719728	350	65	NDQILAEDKHKELFDELVKKFKVEYH
ADK	chr10	76074503	KAT6B	chr10	76719728	409	48	NDQILAEDKHKELFDELVKKFKVEYH

Top

Potential FusionNeoAntigen Information of ADK-KAT6B in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

ADK-KAT6B_76074503_76719728.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:60	FLDKFDEL	0.9951	0.7591	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B44:03	AEDKHKELF	0.9984	0.9865	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:24	FLDKFDELV	0.9976	0.8145	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:30	FLDKFDELV	0.9976	0.8145	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:67	FLDKFDELV	0.9976	0.8145	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:60	FLDKFDELV	0.9976	0.7878	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:11	FLDKFDELV	0.9972	0.8409	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:21	FLDKFDELV	0.9962	0.8882	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B39:24	KHKELFDEL	0.9952	0.7372	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B47:01	AEDKHKELF	0.995	0.6337	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B39:01	KHKELFDEL	0.9944	0.987	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:16	FLDKFDELV	0.9941	0.7473	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:22	FLDKFDELV	0.9938	0.8634	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B39:06	KHKELFDEL	0.9925	0.8032	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:27	FLDKFDELV	0.99	0.7823	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B38:02	KHKELFDEL	0.9882	0.9953	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B39:13	KHKELFDEL	0.9879	0.9881	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B38:01	KHKELFDEL	0.9877	0.995	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B13:01	AEDKHKELF	0.9872	0.7737	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:35	FLDKFDELV	0.9843	0.8476	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A32:13	KFDELVKKF	0.9828	0.9477	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-B14:02	DFLDKFDEL	0.9814	0.76	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-B14:01	DFLDKFDEL	0.9814	0.76	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:13	FLDKFDELV	0.9741	0.8175	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:19	FLDKFDELV	0.9739	0.5658	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:38	FLDKFDELV	0.9738	0.6556	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:04	FLDKFDELV	0.963	0.8974	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:17	FLDKFDELV	0.9468	0.6787	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-B58:02	KFDELVKKF	0.9446	0.92	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:29	FLDKFDELV	0.9413	0.8177	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:20	FLDKFDELV	0.9087	0.8221	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B14:01	KHKELFDEL	0.8921	0.8871	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B14:02	KHKELFDEL	0.8921	0.8871	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B18:01	AEDKHKELF	0.8683	0.9092	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B45:01	AEDKHKELF	0.8575	0.9243	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B15:10	KHKELFDEL	0.7507	0.8722	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B15:18	KHKELFDEL	0.5516	0.9139	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-B08:01	DFLDKFDEL	0.3433	0.7844	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B48:01	KHKELFDEL	0.2638	0.5614	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B41:01	AEDKHKELF	0.2636	0.9514	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B08:01	LFDELVKKF	0.1774	0.8089	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B15:37	KHKELFDEL	0.1506	0.8421	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B39:13	AEDKHKELF	0.1322	0.9713	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B07:10	KHKELFDEL	0.0035	0.5225	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B47:01	KELFDELVKK	0.931	0.6589	10	20
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B15:37	DKHKELFDEL	0.8129	0.5182	7	17
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-A74:03	KELFDELVKK	0.6	0.6403	10	20
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-A74:11	KELFDELVKK	0.6	0.6403	10	20
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-A74:09	KELFDELVKK	0.6	0.6403	10	20
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B47:01	KELFDELVKKF	1	0.5447	10	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B44:03	KELFDELVKKF	0.9999	0.9502	10	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C08:15	FLDKFDEL	1	0.9866	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C04:10	FLDKFDEL	1	0.8656	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C05:09	FLDKFDEL	1	0.9771	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C04:07	FLDKFDEL	1	0.8448	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C04:06	FLDKFDEL	0.9987	0.9516	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C04:14	FLDKFDEL	0.9984	0.8786	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:07	FLDKFDEL	0.9954	0.8114	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C08:04	FLDKFDEL	0.9943	0.9857	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C08:13	FLDKFDEL	0.9943	0.9857	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:02	FLDKFDEL	0.9883	0.639	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C08:03	FLDKFDEL	0.9834	0.9938	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C05:09	FLDKFDELV	0.9995	0.9856	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C05:09	KFDELVKKF	0.999	0.9572	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C05:09	LFDELVKKF	0.9987	0.9588	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C04:10	KFDELVKKF	0.9986	0.8376	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C04:07	KFDELVKKF	0.9985	0.8162	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C04:10	LFDELVKKF	0.9983	0.8728	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C04:07	LFDELVKKF	0.998	0.845	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C07:27	LFDELVKKF	0.998	0.9686	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C07:10	LFDELVKKF	0.9978	0.9678	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C07:67	LFDELVKKF	0.9977	0.955	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C07:80	LFDELVKKF	0.9977	0.955	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:01	FLDKFDELV	0.9976	0.8145	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C07:05	LFDELVKKF	0.9976	0.9745	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:07	FLDKFDELV	0.9975	0.8446	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C07:29	LFDELVKKF	0.9973	0.9708	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C07:19	LFDELVKKF	0.9971	0.6649	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C04:10	FLDKFDELV	0.9971	0.9235	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C07:95	LFDELVKKF	0.997	0.7583	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C08:15	LFDELVKKF	0.9966	0.9787	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C07:46	LFDELVKKF	0.9958	0.8883	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C07:13	LFDELVKKF	0.9958	0.9219	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C04:07	FLDKFDELV	0.9957	0.9071	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C08:15	KFDELVKKF	0.9955	0.9752	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C07:19	KFDELVKKF	0.9948	0.766	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C07:10	KFDELVKKF	0.9946	0.9719	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C07:80	KFDELVKKF	0.9946	0.9657	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C07:67	KFDELVKKF	0.9946	0.9657	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:02	FLDKFDELV	0.9935	0.7917	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B39:09	KHKELFDEL	0.9934	0.7853	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C07:27	KFDELVKKF	0.9934	0.9704	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B39:12	KHKELFDEL	0.9932	0.9879	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:05	FLDKFDELV	0.993	0.8801	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C07:05	KFDELVKKF	0.9929	0.9701	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C07:29	KFDELVKKF	0.9919	0.9605	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C07:95	KFDELVKKF	0.9909	0.7788	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C07:46	KFDELVKKF	0.9898	0.9186	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B39:05	KHKELFDEL	0.9884	0.9843	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C08:15	FLDKFDELV	0.9882	0.99	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C07:13	KFDELVKKF	0.9852	0.9492	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B15:21	LFDELVKKF	0.9734	0.9037	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C04:06	LFDELVKKF	0.9686	0.9028	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C04:14	LFDELVKKF	0.9453	0.8652	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C04:06	FLDKFDELV	0.9435	0.9784	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C12:16	LFDELVKKF	0.9326	0.9765	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C07:13	KHKELFDEL	0.9208	0.9833	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C04:06	KFDELVKKF	0.8887	0.924	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C07:29	KHKELFDEL	0.8685	0.9855	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C04:14	KFDELVKKF	0.8464	0.848	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C07:46	KHKELFDEL	0.6144	0.9722	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-B14:03	DFLDKFDEL	0.4954	0.802	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C12:16	KFDELVKKF	0.3024	0.9757	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B39:08	AEDKHKELF	0.2668	0.9182	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B14:03	KHKELFDEL	0.2166	0.9371	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C12:16	KHKELFDEL	0.0406	0.9892	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C04:01	FLDKFDEL	1	0.8448	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C18:01	FLDKFDEL	1	0.8824	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C08:02	FLDKFDEL	1	0.9866	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C05:01	FLDKFDEL	1	0.9771	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C04:03	FLDKFDEL	1	0.8913	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C01:03	FLDKFDEL	0.9999	0.9669	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C04:04	FLDKFDEL	0.998	0.9434	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C07:04	FLDKFDEL	0.993	0.9624	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C08:01	FLDKFDEL	0.9834	0.9938	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-B08:12	FLDKFDEL	0.9545	0.8942	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-B07:13	FLDKFDEL	0.5608	0.89	9	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C04:03	FLDKFDELV	0.9995	0.9082	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C05:01	FLDKFDELV	0.9995	0.9856	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C04:03	KFDELVKKF	0.999	0.8609	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C05:01	KFDELVKKF	0.999	0.9572	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C04:03	LFDELVKKF	0.9988	0.8825	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C05:01	LFDELVKKF	0.9987	0.9588	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C18:01	FLDKFDELV	0.9986	0.9171	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C04:01	KFDELVKKF	0.9985	0.8162	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B44:13	AEDKHKELF	0.9984	0.9865	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B44:26	AEDKHKELF	0.9984	0.9865	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B44:07	AEDKHKELF	0.9984	0.9865	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C18:01	KFDELVKKF	0.9982	0.8761	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C18:01	LFDELVKKF	0.9982	0.8555	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C04:01	LFDELVKKF	0.998	0.845	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C07:17	LFDELVKKF	0.9979	0.9778	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C07:02	LFDELVKKF	0.9977	0.955	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C07:01	LFDELVKKF	0.9976	0.6926	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C08:02	LFDELVKKF	0.9966	0.9787	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:06	FLDKFDELV	0.9962	0.8882	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A02:14	FLDKFDELV	0.9961	0.8582	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C04:01	FLDKFDELV	0.9957	0.9071	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C08:02	KFDELVKKF	0.9955	0.9752	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C14:03	LFDELVKKF	0.9954	0.9702	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C14:02	LFDELVKKF	0.9954	0.9702	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B39:02	KHKELFDEL	0.9949	0.9889	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C07:02	KFDELVKKF	0.9946	0.9657	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C07:01	KFDELVKKF	0.9942	0.7204	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B39:31	KHKELFDEL	0.9942	0.9871	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C03:67	LFDELVKKF	0.9932	0.9788	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C18:01	AEDKHKELF	0.9923	0.89	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C07:17	KFDELVKKF	0.9922	0.9762	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C08:02	FLDKFDELV	0.9882	0.99	9	18
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B38:05	KHKELFDEL	0.9877	0.995	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C07:04	LFDELVKKF	0.9871	0.9382	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B40:04	AEDKHKELF	0.9861	0.6611	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C06:06	LFDELVKKF	0.9856	0.9887	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-A32:01	KFDELVKKF	0.9843	0.9684	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C14:03	KFDELVKKF	0.9841	0.964	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C14:02	KFDELVKKF	0.9841	0.964	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C07:22	KFDELVKKF	0.9728	0.8001	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C04:04	LFDELVKKF	0.9665	0.8658	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C07:04	KFDELVKKF	0.9615	0.956	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C06:06	KFDELVKKF	0.9442	0.9897	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B15:13	LFDELVKKF	0.934	0.5557	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C04:04	KFDELVKKF	0.8709	0.9175	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B18:05	AEDKHKELF	0.8683	0.9092	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B18:08	AEDKHKELF	0.8605	0.8943	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B18:03	AEDKHKELF	0.8251	0.904	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-C03:67	KFDELVKKF	0.817	0.9824	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B18:11	AEDKHKELF	0.7971	0.9563	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B15:09	KHKELFDEL	0.7378	0.6973	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-B15:13	KFDELVKKF	0.7355	0.5983	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B39:11	KHKELFDEL	0.579	0.9636	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-C07:04	KHKELFDEL	0.5469	0.9881	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-B08:12	DFLDKFDEL	0.5385	0.843	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B08:12	LFDELVKKF	0.4621	0.9208	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B48:02	AEDKHKELF	0.3561	0.9362	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-B08:18	DFLDKFDEL	0.3433	0.7844	8	17
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B41:03	AEDKHKELF	0.3292	0.7548	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B39:11	AEDKHKELF	0.2657	0.8764	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B08:18	LFDELVKKF	0.1774	0.8089	12	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B39:02	AEDKHKELF	0.0951	0.9726	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B15:53	AEDKHKELF	0.08	0.9161	5	14
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-A25:01	ELFDELVKKF	0.9894	0.9103	11	21
ADK-KAT6B	chr10	76074503	chr10	76719728	278	HLA-B57:02	VVDKDFLDKF	0.9867	0.8988	4	14
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-A74:01	KELFDELVKK	0.6	0.6403	10	20
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B44:26	KELFDELVKKF	0.9999	0.9502	10	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B44:07	KELFDELVKKF	0.9999	0.9502	10	21
ADK-KAT6B	chr10	76074503	chr10	76719728	323	HLA-B44:13	KELFDELVKKF	0.9999	0.9502	10	21

Top

Potential FusionNeoAntigen Information of ADK-KAT6B in HLA II

ADK-KAT6B_76074503_76719728.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-0307	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-0310	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-0315	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-0324	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-0805	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-0806	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-0810	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-0812	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-0818	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-0822	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-0840	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1107	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1134	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1159	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1179	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1183	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1303	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1304	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1309	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-13101	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-13101	DQILAEDKHKELFDE	1	16
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1310	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1310	DQILAEDKHKELFDE	1	16
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1312	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1313	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1321	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1327	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1330	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1332	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1332	DQILAEDKHKELFDE	1	16
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1333	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1333	DQILAEDKHKELFDE	1	16
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1338	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1343	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1344	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1348	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1348	DQILAEDKHKELFDE	1	16
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1349	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1358	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1358	DQILAEDKHKELFDE	1	16
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1365	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1366	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1371	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1375	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1381	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1381	DQILAEDKHKELFDE	1	16
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1388	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1388	DQILAEDKHKELFDE	1	16
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1389	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1389	DQILAEDKHKELFDE	1	16
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1390	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1393	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1394	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1394	DQILAEDKHKELFDE	1	16
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1395	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1413	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1416	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1417	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1421	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1433	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1437	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1465	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1469	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1474	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1476	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1478	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1479	NDQILAEDKHKELFD	0	15
ADK-KAT6B	chr10	76074503	chr10	76719728	323	DRB1-1480	NDQILAEDKHKELFD	0	15

Top

Fusion breakpoint peptide structures of ADK-KAT6B

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
1168	DKDFLDKFDELVKK	ADK	KAT6B	chr10	76074503	chr10	76719728	278

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
1595	EDKHKELFDELVKK	ADK	KAT6B	chr10	76074503	chr10	76719728	323

Top

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ADK-KAT6B

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	1168	DKDFLDKFDELVKK	-7.9962	-8.1096
HLA-B14:02	3BVN	1168	DKDFLDKFDELVKK	-5.70842	-6.74372
HLA-B52:01	3W39	1168	DKDFLDKFDELVKK	-6.83737	-6.95077
HLA-B52:01	3W39	1168	DKDFLDKFDELVKK	-4.4836	-5.5189
HLA-A11:01	4UQ2	1168	DKDFLDKFDELVKK	-10.0067	-10.1201
HLA-A11:01	4UQ2	1168	DKDFLDKFDELVKK	-9.03915	-10.0745
HLA-A24:02	5HGA	1168	DKDFLDKFDELVKK	-6.56204	-6.67544
HLA-A24:02	5HGA	1168	DKDFLDKFDELVKK	-5.42271	-6.45801
HLA-B44:05	3DX8	1168	DKDFLDKFDELVKK	-7.85648	-8.89178
HLA-B44:05	3DX8	1168	DKDFLDKFDELVKK	-5.3978	-5.5112
HLA-A02:01	6TDR	1168	DKDFLDKFDELVKK	-3.37154	-4.40684
HLA-B14:02	3BVN	1595	EDKHKELFDELVKK	-7.9962	-8.1096
HLA-B14:02	3BVN	1595	EDKHKELFDELVKK	-5.70842	-6.74372
HLA-B52:01	3W39	1595	EDKHKELFDELVKK	-6.83737	-6.95077
HLA-B52:01	3W39	1595	EDKHKELFDELVKK	-4.4836	-5.5189
HLA-A11:01	4UQ2	1595	EDKHKELFDELVKK	-10.0067	-10.1201
HLA-A11:01	4UQ2	1595	EDKHKELFDELVKK	-9.03915	-10.0745
HLA-A24:02	5HGA	1595	EDKHKELFDELVKK	-6.56204	-6.67544
HLA-A24:02	5HGA	1595	EDKHKELFDELVKK	-5.42271	-6.45801
HLA-B44:05	3DX8	1595	EDKHKELFDELVKK	-7.85648	-8.89178
HLA-B44:05	3DX8	1595	EDKHKELFDELVKK	-5.3978	-5.5112
HLA-A02:01	6TDR	1595	EDKHKELFDELVKK	-3.37154	-4.40684

Top

Vaccine Design for the FusionNeoAntigens of ADK-KAT6B

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
ADK-KAT6B	chr10	76074503	chr10	76719728	10	20	KELFDELVKK	GTGGCTCAGCCCCGTGCTGATCCCATTCCA
ADK-KAT6B	chr10	76074503	chr10	76719728	10	21	KELFDELVKKF	GTGGCTCAGCCCCGTGCTGATCCCATTCCAATA
ADK-KAT6B	chr10	76074503	chr10	76719728	11	21	ELFDELVKKF	GCTCAGCCCCGTGCTGATCCCATTCCAATA
ADK-KAT6B	chr10	76074503	chr10	76719728	12	21	KFDELVKKF	CAGCCCCGTGCTGATCCCATTCCAATA
ADK-KAT6B	chr10	76074503	chr10	76719728	12	21	LFDELVKKF	CAGCCCCGTGCTGATCCCATTCCAATA
ADK-KAT6B	chr10	76074503	chr10	76719728	4	14	VVDKDFLDKF	ACCCAGAATTCAATTAAAGTGGCTCAGCCC
ADK-KAT6B	chr10	76074503	chr10	76719728	5	14	AEDKHKELF	CAGAATTCAATTAAAGTGGCTCAGCCC
ADK-KAT6B	chr10	76074503	chr10	76719728	7	17	DKHKELFDEL	TCAATTAAAGTGGCTCAGCCCCGTGCTGAT
ADK-KAT6B	chr10	76074503	chr10	76719728	8	17	DFLDKFDEL	ATTAAAGTGGCTCAGCCCCGTGCTGAT
ADK-KAT6B	chr10	76074503	chr10	76719728	8	17	KHKELFDEL	ATTAAAGTGGCTCAGCCCCGTGCTGAT
ADK-KAT6B	chr10	76074503	chr10	76719728	9	17	FLDKFDEL	AAAGTGGCTCAGCCCCGTGCTGAT
ADK-KAT6B	chr10	76074503	chr10	76719728	9	18	FLDKFDELV	AAAGTGGCTCAGCCCCGTGCTGATCCC

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
ADK-KAT6B	chr10	76074503	chr10	76719728	0	15	NDQILAEDKHKELFD	GCTGGTGGCTCTACCCAGAATTCAATTAAAGTGGCTCAGCCCCGT
ADK-KAT6B	chr10	76074503	chr10	76719728	1	16	DQILAEDKHKELFDE	GGTGGCTCTACCCAGAATTCAATTAAAGTGGCTCAGCCCCGTGCT

Top

Information of the samples that have these potential fusion neoantigens of ADK-KAT6B

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
BRCA	ADK-KAT6B	chr10	76074503	ENST00000286621	chr10	76719728	ENST00000287239	TCGA-D8-A1JC-01A
BRCA	ADK-KAT6B	chr10	76074503	ENST00000541550	chr10	76719728	ENST00000287239	TCGA-D8-A1JC-01A

Top

Potential target of CAR-T therapy development for ADK-KAT6B

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

Top

Related Drugs to ADK-KAT6B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ADK-KAT6B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)