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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:ABCC3-DHDH

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ABCC3-DHDH
FusionPDB ID: 256
FusionGDB2.0 ID: 256
HgeneTgene
Gene symbol

ABCC3

DHDH

Gene ID

8714

27294

Gene nameATP binding cassette subfamily C member 3dihydrodiol dehydrogenase
SynonymsABC31|EST90757|MLP2|MOAT-D|MRP3|cMOAT22DD|HUM2DD
Cytomap

17q21.33

19q13.33

Type of geneprotein-codingprotein-coding
Descriptioncanalicular multispecific organic anion transporter 2ATP-binding cassette sub-family C member 3ATP-binding cassette, sub-family C (CFTR/MRP), member 3canicular multispecific organic anion transportermulti-specific organic anion transporter Dmultidrugtrans-1,2-dihydrobenzene-1,2-diol dehydrogenase3-deoxyglucosone reductaseD-xylose 1-dehydrogenaseD-xylose-NADP dehydrogenasedihydrodiol dehydrogenase (dimeric)
Modification date2020031320200313
UniProtAcc

O15438

Main function of 5'-partner protein: FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:11581266, PubMed:15083066, PubMed:10359813). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:15083066, PubMed:11581266). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). Can confers resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:11581266, PubMed:10359813). {ECO:0000250|UniProtKB:O88563, ECO:0000269|PubMed:10359813, ECO:0000269|PubMed:11581266, ECO:0000269|PubMed:15083066}.

Q9UQ10

Main function of 5'-partner protein:
Ensembl transtripts involved in fusion geneENST idsENST00000285238, ENST00000427699, 
ENST00000515707, ENST00000510891, 
ENST00000221403, ENST00000522614, 
ENST00000523250, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 12 X 7=13445 X 4 X 3=60
# samples 186
** MAII scorelog2(18/1344*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/60*10)=0
Fusion gene context

PubMed: ABCC3 [Title/Abstract] AND DHDH [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: ABCC3 [Title/Abstract] AND DHDH [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ABCC3(48712342)-DHDH(49438257), # samples:2
Anticipated loss of major functional domain due to fusion event.ABCC3-DHDH seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC3-DHDH seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABCC3

GO:0042908

xenobiotic transport

18698235|19334674



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:48712342/chr19:49438257)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across ABCC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DHDH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000285238ABCC3chr1748712342+ENST00000221403DHDHchr1949438257+1076125591039326
ENST00000285238ABCC3chr1748712342+ENST00000523250DHDHchr1949438257+64912559622187
ENST00000285238ABCC3chr1748712342+ENST00000522614DHDHchr1949438257+79412559763234
ENST00000515707ABCC3chr1748712342+ENST00000221403DHDHchr1949438257+104594491008319
ENST00000515707ABCC3chr1748712342+ENST00000523250DHDHchr1949438257+6189449591180
ENST00000515707ABCC3chr1748712342+ENST00000522614DHDHchr1949438257+7639449732227
ENST00000427699ABCC3chr1748712342+ENST00000221403DHDHchr1949438257+1076125591039326
ENST00000427699ABCC3chr1748712342+ENST00000523250DHDHchr1949438257+64912559622187
ENST00000427699ABCC3chr1748712342+ENST00000522614DHDHchr1949438257+79412559763234

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000285238ENST00000221403ABCC3chr1748712342+DHDHchr1949438257+0.0046528830.9953471
ENST00000285238ENST00000523250ABCC3chr1748712342+DHDHchr1949438257+0.0175877140.9824123
ENST00000285238ENST00000522614ABCC3chr1748712342+DHDHchr1949438257+0.0041407020.9958593
ENST00000515707ENST00000221403ABCC3chr1748712342+DHDHchr1949438257+0.0038686690.9961313
ENST00000515707ENST00000523250ABCC3chr1748712342+DHDHchr1949438257+0.0248795190.97512054
ENST00000515707ENST00000522614ABCC3chr1748712342+DHDHchr1949438257+0.0041274960.99587256
ENST00000427699ENST00000221403ABCC3chr1748712342+DHDHchr1949438257+0.0046528830.9953471
ENST00000427699ENST00000523250ABCC3chr1748712342+DHDHchr1949438257+0.0175877140.9824123
ENST00000427699ENST00000522614ABCC3chr1748712342+DHDHchr1949438257+0.0041407020.9958593

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for ABCC3-DHDH

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
ABCC3chr1748712342DHDHchr194943825712522ALCGSGELGSKFWVVAVAARDLSRAK
ABCC3chr1748712342DHDHchr19494382579415ALCGSGELGSKFWVVAVAARDLSRAK

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Potential FusionNeoAntigen Information of ABCC3-DHDH in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
ABCC3-DHDH_48712342_49438257.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
ABCC3-DHDHchr1748712342chr1949438257125HLA-B40:02GELGSKFWV0.99790.6828514
ABCC3-DHDHchr1748712342chr1949438257125HLA-B39:06SKFWVVAVA0.99490.9537918
ABCC3-DHDHchr1748712342chr1949438257125HLA-B08:01ELGSKFWVV0.91970.8677615
ABCC3-DHDHchr1748712342chr1949438257125HLA-B08:09ELGSKFWVV0.90910.9408615
ABCC3-DHDHchr1748712342chr1949438257125HLA-A02:19ELGSKFWVV0.85370.6841615
ABCC3-DHDHchr1748712342chr1949438257125HLA-A31:02KFWVVAVAAR0.97820.9261020
ABCC3-DHDHchr1748712342chr1949438257125HLA-B45:01GELGSKFWVVA0.99840.9967516
ABCC3-DHDHchr1748712342chr1949438257125HLA-B50:02GELGSKFWVVA0.99790.9228516
ABCC3-DHDHchr1748712342chr1949438257125HLA-B41:01GELGSKFWVVA0.96950.9944516
ABCC3-DHDHchr1748712342chr1949438257125HLA-B50:01GELGSKFWVVA0.96770.9646516
ABCC3-DHDHchr1748712342chr1949438257125HLA-B40:06GELGSKFWV0.99690.8012514
ABCC3-DHDHchr1748712342chr1949438257125HLA-B73:01SKFWVVAVA0.77120.9412918
ABCC3-DHDHchr1748712342chr1949438257125HLA-B40:06GELGSKFWVVA0.99960.9581516
ABCC3-DHDHchr1748712342chr1949438257125HLA-B08:18ELGSKFWVV0.91970.8677615
ABCC3-DHDHchr1748712342chr1949438257125HLA-B08:12ELGSKFWVV0.5050.9253615
ABCC3-DHDHchr1748712342chr1949438257125HLA-B50:04GELGSKFWVVA0.96770.9646516
ABCC3-DHDHchr1748712342chr1949438257125HLA-B50:05GELGSKFWVVA0.96770.9646516

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Potential FusionNeoAntigen Information of ABCC3-DHDH in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
ABCC3-DHDH_48712342_49438257.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0123KFWVVAVAARDLSRA1025
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0405SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0417SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0424SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0424GSKFWVVAVAARDLS823
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0429SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0430SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0445SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0448SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0454SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0457SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0469SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0469GSKFWVVAVAARDLS823
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0477SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0480SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0482SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0483SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0484SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0486SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0486GSKFWVVAVAARDLS823
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0487SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0489SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0706SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0801SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0803SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0803GSKFWVVAVAARDLS823
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0808SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0811SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0814SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0814GSKFWVVAVAARDLS823
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0816SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0818SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0823SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0823GSKFWVVAVAARDLS823
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0826SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0827SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0827GSKFWVVAVAARDLS823
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0829SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0832SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0832GSKFWVVAVAARDLS823
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0833SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0833GSKFWVVAVAARDLS823
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0835SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0835GSKFWVVAVAARDLS823
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0836SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0836GSKFWVVAVAARDLS823
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0837SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0838SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0838GSKFWVVAVAARDLS823
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0839SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0901SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0902SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0902GSKFWVVAVAARDLS823
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0903SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0904SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0905SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0907SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0908SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0908GSKFWVVAVAARDLS823
ABCC3-DHDHchr1748712342chr1949438257125DRB1-0909SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-1001SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-1003SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-1313SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-1463SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB1-1485SKFWVVAVAARDLSR924
ABCC3-DHDHchr1748712342chr1949438257125DRB5-0112SKFWVVAVAARDLSR924

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Fusion breakpoint peptide structures of ABCC3-DHDH

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
1898ELGSKFWVVAVAARABCC3DHDHchr1748712342chr1949438257125

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ABCC3-DHDH

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN1898ELGSKFWVVAVAAR-7.15543-7.26883
HLA-B14:023BVN1898ELGSKFWVVAVAAR-4.77435-5.80965
HLA-B52:013W391898ELGSKFWVVAVAAR-6.80875-6.92215
HLA-B52:013W391898ELGSKFWVVAVAAR-4.20386-5.23916
HLA-A11:014UQ21898ELGSKFWVVAVAAR-7.5194-8.5547
HLA-A11:014UQ21898ELGSKFWVVAVAAR-6.9601-7.0735
HLA-A24:025HGA1898ELGSKFWVVAVAAR-7.52403-7.63743
HLA-A24:025HGA1898ELGSKFWVVAVAAR-5.82433-6.85963
HLA-B27:056PYJ1898ELGSKFWVVAVAAR-3.28285-4.31815
HLA-B44:053DX81898ELGSKFWVVAVAAR-5.91172-6.94702
HLA-B44:053DX81898ELGSKFWVVAVAAR-4.24346-4.35686

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Vaccine Design for the FusionNeoAntigens of ABCC3-DHDH

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
ABCC3-DHDHchr1748712342chr19494382571020KFWVVAVAARAAGTTCTGGGTGGTGGCGGTGGCGGCCCGC
ABCC3-DHDHchr1748712342chr1949438257514GELGSKFWVGGGGAGCTCGGCTCCAAGTTCTGGGTG
ABCC3-DHDHchr1748712342chr1949438257516GELGSKFWVVAGGGGAGCTCGGCTCCAAGTTCTGGGTGGTGGCG
ABCC3-DHDHchr1748712342chr1949438257615ELGSKFWVVGAGCTCGGCTCCAAGTTCTGGGTGGTG
ABCC3-DHDHchr1748712342chr1949438257918SKFWVVAVATCCAAGTTCTGGGTGGTGGCGGTGGCG

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
ABCC3-DHDHchr1748712342chr19494382571025KFWVVAVAARDLSRAAAGTTCTGGGTGGTGGCGGTGGCGGCCCGCGATCTGAGCCGTGCG
ABCC3-DHDHchr1748712342chr1949438257823GSKFWVVAVAARDLSGGCTCCAAGTTCTGGGTGGTGGCGGTGGCGGCCCGCGATCTGAGC
ABCC3-DHDHchr1748712342chr1949438257924SKFWVVAVAARDLSRTCCAAGTTCTGGGTGGTGGCGGTGGCGGCCCGCGATCTGAGCCGT

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Information of the samples that have these potential fusion neoantigens of ABCC3-DHDH

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
STADABCC3-DHDHchr1748712342ENST00000285238chr1949438257ENST00000221403TCGA-HU-A4HD-01A

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Potential target of CAR-T therapy development for ABCC3-DHDH

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to ABCC3-DHDH

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ABCC3-DHDH

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource