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Fusion Protein:EIF2AK1-PHF14 |
Fusion Gene and Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: EIF2AK1-PHF14 | FusionPDB ID: 25657 | FusionGDB2.0 ID: 25657 | Hgene | Tgene | Gene symbol | EIF2AK1 | PHF14 | Gene ID | 27102 | 9678 |
Gene name | eukaryotic translation initiation factor 2 alpha kinase 1 | PHD finger protein 14 | |
Synonyms | HCR|HRI | - | |
Cytomap | 7p22.1 | 7p21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | eukaryotic translation initiation factor 2-alpha kinase 1heme regulated initiation factor 2 alpha kinaseheme sensitive initiation factor 2a kinaseheme-controlled repressorheme-regulated eukaryotic initiation factor eIF-2-alpha kinaseheme-regulated in | PHD finger protein 14 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q9BQI3 Main function of 5'-partner protein: FUNCTION: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:32132706, PubMed:32132707). Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock (PubMed:32132706, PubMed:32132707). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707). Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity (By similarity). This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR (By similarity). Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions (By similarity). In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties (By similarity). It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (By similarity). Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes (By similarity). May also regulate endoplasmic reticulum (ER) stress during acute heme-deficient conditions (By similarity). Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707). {ECO:0000250|UniProtKB:Q9Z2R9, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:32197074}. | . | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000199389, ENST00000536084, ENST00000495565, | ENST00000469407, ENST00000403050, ENST00000445996, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 11 X 8 X 8=704 | 22 X 10 X 15=3300 |
# samples | 11 | 23 | |
** MAII score | log2(11/704*10)=-2.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(23/3300*10)=-3.8427602581888 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Fusion gene context | PubMed: EIF2AK1 [Title/Abstract] AND PHF14 [Title/Abstract] AND fusion [Title/Abstract] | ||
Fusion neoantigen context | PubMed: EIF2AK1 [Title/Abstract] AND PHF14 [Title/Abstract] AND neoantigen [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | EIF2AK1(6094177)-PHF14(11091239), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | EIF2AK1-PHF14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EIF2AK1-PHF14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EIF2AK1-PHF14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EIF2AK1-PHF14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EIF2AK1-PHF14 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. EIF2AK1-PHF14 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. EIF2AK1-PHF14 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | EIF2AK1 | GO:1990641 | response to iron ion starvation | 11036079 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:6094177/chr7:11091239) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Amino Acid Sequences |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000536084 | EIF2AK1 | chr7 | 6094177 | - | ENST00000403050 | PHF14 | chr7 | 11091239 | + | 1870 | 358 | 12 | 470 | 152 |
ENST00000536084 | EIF2AK1 | chr7 | 6094177 | - | ENST00000445996 | PHF14 | chr7 | 11091239 | + | 893 | 358 | 395 | 892 | 166 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000536084 | ENST00000403050 | EIF2AK1 | chr7 | 6094177 | - | PHF14 | chr7 | 11091239 | + | 0.008570514 | 0.9914295 |
ENST00000536084 | ENST00000445996 | EIF2AK1 | chr7 | 6094177 | - | PHF14 | chr7 | 11091239 | + | 0.00626722 | 0.99373275 |
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Get the fusion protein sequences from here. |
Fusion protein sequence information is available in the fasta format. >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP |
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Fusion Protein Breakpoint Sequences for EIF2AK1-PHF14 |
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Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Length(fusion protein) | BP in fusion protein | Peptide |
EIF2AK1 | chr7 | 6094177 | PHF14 | chr7 | 11091239 | 358 | 116 | EPNPLRSRQVFKRSARNVTRQGAVTW |
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Potential FusionNeoAntigen Information of EIF2AK1-PHF14 in HLA I |
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EIF2AK1-PHF14_6094177_11091239.msa |
![]() * We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5) |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA I | FusionNeoAntigen peptide | Binding score | Immunogenic score | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | HLA-B27:05 | KRSARNVTR | 0.9986 | 0.836 | 11 | 20 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | HLA-B39:06 | SRQVFKRSA | 0.987 | 0.6647 | 6 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | HLA-A30:08 | RSRQVFKRS | 0.985 | 0.5864 | 5 | 14 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | HLA-A30:08 | RSRQVFKRSA | 0.9833 | 0.709 | 5 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | HLA-A31:02 | VFKRSARNVTR | 0.9318 | 0.8546 | 9 | 20 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | HLA-B27:14 | KRSARNVTR | 0.9984 | 0.8602 | 11 | 20 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | HLA-B27:14 | SRQVFKRSA | 0.995 | 0.6079 | 6 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | HLA-B73:01 | SRQVFKRSA | 0.9945 | 0.6619 | 6 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | HLA-B27:03 | KRSARNVTR | 0.96 | 0.8582 | 11 | 20 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | HLA-B27:10 | KRSARNVTR | 0.9974 | 0.8867 | 11 | 20 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | HLA-A30:01 | RSRQVFKRS | 0.987 | 0.7889 | 5 | 14 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | HLA-A30:01 | RSRQVFKRSA | 0.9843 | 0.8394 | 5 | 15 |
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Potential FusionNeoAntigen Information of EIF2AK1-PHF14 in HLA II |
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EIF2AK1-PHF14_6094177_11091239.msa |
![]() * We used NetMHCIIpan v4.1 (%rank<0.5). |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA II | FusionNeoAntigen peptide | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1102 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1102 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1111 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1116 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1116 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1121 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1121 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1127 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1136 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1137 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1148 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1153 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1153 | SRQVFKRSARNVTRQ | 6 | 21 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1155 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1165 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1165 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1169 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1169 | SRQVFKRSARNVTRQ | 6 | 21 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1170 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1170 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1180 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1182 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1186 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1187 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1193 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1193 | SRQVFKRSARNVTRQ | 6 | 21 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1301 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1301 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1307 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1308 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1315 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1315 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1316 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1317 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1317 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1319 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1319 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1320 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1322 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1322 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1326 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1326 | SRQVFKRSARNVTRQ | 6 | 21 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1327 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1335 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1335 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1336 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1337 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1337 | SRQVFKRSARNVTRQ | 6 | 21 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1347 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1351 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1351 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1352 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1352 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1353 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1353 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1357 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1357 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1359 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1359 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1360 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1361 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1361 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1363 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1364 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1364 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1368 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1368 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1369 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1369 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1370 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1371 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1372 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1378 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1379 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1379 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1380 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1380 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1383 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1383 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1384 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1385 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1385 | SRQVFKRSARNVTRQ | 6 | 21 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1387 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1387 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1391 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1391 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1392 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1392 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1398 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1398 | EPNPLRSRQVFKRSA | 0 | 15 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1403 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1407 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1407 | SRQVFKRSARNVTRQ | 6 | 21 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1412 | PNPLRSRQVFKRSAR | 1 | 16 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1414 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1414 | SRQVFKRSARNVTRQ | 6 | 21 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1414 | RSRQVFKRSARNVTR | 5 | 20 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1422 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1424 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1424 | SRQVFKRSARNVTRQ | 6 | 21 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1425 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1427 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1436 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1436 | SRQVFKRSARNVTRQ | 6 | 21 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1436 | RSRQVFKRSARNVTR | 5 | 20 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1440 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1442 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1442 | SRQVFKRSARNVTRQ | 6 | 21 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1444 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1444 | SRQVFKRSARNVTRQ | 6 | 21 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1444 | RSRQVFKRSARNVTR | 5 | 20 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1451 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1451 | SRQVFKRSARNVTRQ | 6 | 21 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1477 | RQVFKRSARNVTRQG | 7 | 22 |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 | DRB1-1498 | RQVFKRSARNVTRQG | 7 | 22 |
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Fusion breakpoint peptide structures of EIF2AK1-PHF14 |
![]() * The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA. |
File name | BPseq | Hgene | Tgene | Hchr | Hbp | Tchr | Tbp | AAlen |
8976 | SRQVFKRSARNVTR | EIF2AK1 | PHF14 | chr7 | 6094177 | chr7 | 11091239 | 358 |
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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of EIF2AK1-PHF14 |
![]() * We used Glide to predict the interaction between HLAs and neoantigens. |
HLA allele | PDB ID | File name | BPseq | Docking score | Glide score |
HLA-B14:02 | 3BVN | 8976 | SRQVFKRSARNVTR | -7.15543 | -7.26883 |
HLA-B14:02 | 3BVN | 8976 | SRQVFKRSARNVTR | -4.77435 | -5.80965 |
HLA-B52:01 | 3W39 | 8976 | SRQVFKRSARNVTR | -6.80875 | -6.92215 |
HLA-B52:01 | 3W39 | 8976 | SRQVFKRSARNVTR | -4.20386 | -5.23916 |
HLA-A11:01 | 4UQ2 | 8976 | SRQVFKRSARNVTR | -7.5194 | -8.5547 |
HLA-A11:01 | 4UQ2 | 8976 | SRQVFKRSARNVTR | -6.9601 | -7.0735 |
HLA-A24:02 | 5HGA | 8976 | SRQVFKRSARNVTR | -7.52403 | -7.63743 |
HLA-A24:02 | 5HGA | 8976 | SRQVFKRSARNVTR | -5.82433 | -6.85963 |
HLA-B27:05 | 6PYJ | 8976 | SRQVFKRSARNVTR | -3.28285 | -4.31815 |
HLA-B44:05 | 3DX8 | 8976 | SRQVFKRSARNVTR | -5.91172 | -6.94702 |
HLA-B44:05 | 3DX8 | 8976 | SRQVFKRSARNVTR | -4.24346 | -4.35686 |
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Vaccine Design for the FusionNeoAntigens of EIF2AK1-PHF14 |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide sequence | FusionNeoAntigen RNA sequence |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 11 | 20 | KRSARNVTR | TTAAGCGCAGTGCTCGGAATGTGACCA |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 5 | 14 | RSRQVFKRS | TTCGTTCAAGACAGGTGTTTAAGCGCA |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 5 | 15 | RSRQVFKRSA | TTCGTTCAAGACAGGTGTTTAAGCGCAGTG |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 6 | 15 | SRQVFKRSA | GTTCAAGACAGGTGTTTAAGCGCAGTG |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 9 | 20 | VFKRSARNVTR | AGGTGTTTAAGCGCAGTGCTCGGAATGTGACCA |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide | FusionNEoAntigen RNA sequence |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 0 | 15 | EPNPLRSRQVFKRSA | ATGAACCAAACCCACTTCGTTCAAGACAGGTGTTTAAGCGCAGTG |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 1 | 16 | PNPLRSRQVFKRSAR | AACCAAACCCACTTCGTTCAAGACAGGTGTTTAAGCGCAGTGCTC |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 5 | 20 | RSRQVFKRSARNVTR | TTCGTTCAAGACAGGTGTTTAAGCGCAGTGCTCGGAATGTGACCA |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 6 | 21 | SRQVFKRSARNVTRQ | GTTCAAGACAGGTGTTTAAGCGCAGTGCTCGGAATGTGACCAGGC |
EIF2AK1-PHF14 | chr7 | 6094177 | chr7 | 11091239 | 7 | 22 | RQVFKRSARNVTRQG | CAAGACAGGTGTTTAAGCGCAGTGCTCGGAATGTGACCAGGCAGG |
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Information of the samples that have these potential fusion neoantigens of EIF2AK1-PHF14 |
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Cancer type | Fusion gene | Hchr | Hbp | Henst | Tchr | Tbp | Tenst | Sample |
SARC | EIF2AK1-PHF14 | chr7 | 6094177 | ENST00000536084 | chr7 | 11091239 | ENST00000403050 | TCGA-JV-A75J-01A |
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Potential target of CAR-T therapy development for EIF2AK1-PHF14 |
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![]() * Minus value of BPloci means that the break point is located before the CDS. |
- In-frame and retained 'Transmembrane'. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
![]() * We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image. |
Hgene | Hchr | Hbp | Henst | Tgene | Tchr | Tbp | Tenst | DeepLoc result |
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Related Drugs to EIF2AK1-PHF14 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to EIF2AK1-PHF14 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |