Home

Download

Statistics

Examples

Help

Contact

Fusion Protein:EIF4G3-RAP1GAP

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: EIF4G3-RAP1GAP
	FusionPDB ID: 26060
	FusionGDB2.0 ID: 26060
		Hgene	Tgene
	Gene symbol	EIF4G3	RAP1GAP
	Gene ID	8672	5909
	Gene name	eukaryotic translation initiation factor 4 gamma 3	RAP1 GTPase activating protein
	Synonyms	eIF-4G 3\|eIF4G 3\|eIF4GII	RAP1GA1\|RAP1GAP1\|RAP1GAPII\|RAPGAP
	Cytomap	1p36.12	1p36.12
	Type of gene	protein-coding	protein-coding
	Description	eukaryotic translation initiation factor 4 gamma 3eIF-4-gamma 3eIF-4-gamma II	rap1 GTPase-activating protein 1
	Modification date	20200313	20200313
	UniProtAcc	O43432 Main function of 5'-partner protein: FUNCTION: Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1. {ECO:0000269\|PubMed:9418880}.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000264211, ENST00000356916, ENST00000374927, ENST00000374935, ENST00000374937, ENST00000400422, ENST00000602326, ENST00000374933, ENST00000536266, ENST00000537738, ENST00000544689,	ENST00000374757, ENST00000290101, ENST00000374761, ENST00000374763, ENST00000374765, ENST00000542643,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	22 X 20 X 11=4840	5 X 5 X 5=125
	# samples	32	6
	** MAII score	log2(32/4840*10)=-3.91886323727459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/125*10)=-1.05889368905357 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: EIF4G3 [Title/Abstract] AND RAP1GAP [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: EIF4G3 [Title/Abstract] AND RAP1GAP [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	EIF4G3(21329206)-RAP1GAP(21945565), # samples:2
Anticipated loss of major functional domain due to fusion event.	EIF4G3-RAP1GAP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EIF4G3-RAP1GAP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EIF4G3-RAP1GAP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EIF4G3-RAP1GAP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EIF4G3-RAP1GAP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. EIF4G3-RAP1GAP seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. EIF4G3-RAP1GAP seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	RAP1GAP	GO:0043087	regulation of GTPase activity	18309292
Tgene	RAP1GAP	GO:0043547	positive regulation of GTPase activity	15141215

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:21329206/chr1:21945565)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across EIF4G3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RAP1GAP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000264211	EIF4G3	chr1	21329205	-	ENST00000374761	RAP1GAP	chr1	21945565	-	3283	225	168	2198	676
ENST00000264211	EIF4G3	chr1	21329205	-	ENST00000290101	RAP1GAP	chr1	21945565	-	3283	225	168	2198	676
ENST00000264211	EIF4G3	chr1	21329205	-	ENST00000374763	RAP1GAP	chr1	21945565	-	3532	225	168	2453	761
ENST00000264211	EIF4G3	chr1	21329205	-	ENST00000374765	RAP1GAP	chr1	21945565	-	3277	225	168	2198	676
ENST00000264211	EIF4G3	chr1	21329205	-	ENST00000542643	RAP1GAP	chr1	21945565	-	3330	225	168	2252	694
ENST00000374935	EIF4G3	chr1	21329205	-	ENST00000374761	RAP1GAP	chr1	21945565	-	3191	133	76	2106	676
ENST00000374935	EIF4G3	chr1	21329205	-	ENST00000290101	RAP1GAP	chr1	21945565	-	3191	133	76	2106	676
ENST00000374935	EIF4G3	chr1	21329205	-	ENST00000374763	RAP1GAP	chr1	21945565	-	3440	133	76	2361	761
ENST00000374935	EIF4G3	chr1	21329205	-	ENST00000374765	RAP1GAP	chr1	21945565	-	3185	133	76	2106	676
ENST00000374935	EIF4G3	chr1	21329205	-	ENST00000542643	RAP1GAP	chr1	21945565	-	3238	133	76	2160	694
ENST00000374937	EIF4G3	chr1	21329205	-	ENST00000374761	RAP1GAP	chr1	21945565	-	3249	191	134	2164	676
ENST00000374937	EIF4G3	chr1	21329205	-	ENST00000290101	RAP1GAP	chr1	21945565	-	3249	191	134	2164	676
ENST00000374937	EIF4G3	chr1	21329205	-	ENST00000374763	RAP1GAP	chr1	21945565	-	3498	191	134	2419	761
ENST00000374937	EIF4G3	chr1	21329205	-	ENST00000374765	RAP1GAP	chr1	21945565	-	3243	191	134	2164	676
ENST00000374937	EIF4G3	chr1	21329205	-	ENST00000542643	RAP1GAP	chr1	21945565	-	3296	191	134	2218	694
ENST00000356916	EIF4G3	chr1	21329205	-	ENST00000374761	RAP1GAP	chr1	21945565	-	3585	527	128	2500	790
ENST00000356916	EIF4G3	chr1	21329205	-	ENST00000290101	RAP1GAP	chr1	21945565	-	3585	527	128	2500	790
ENST00000356916	EIF4G3	chr1	21329205	-	ENST00000374763	RAP1GAP	chr1	21945565	-	3834	527	128	2755	875
ENST00000356916	EIF4G3	chr1	21329205	-	ENST00000374765	RAP1GAP	chr1	21945565	-	3579	527	128	2500	790
ENST00000356916	EIF4G3	chr1	21329205	-	ENST00000542643	RAP1GAP	chr1	21945565	-	3632	527	128	2554	808
ENST00000264211	EIF4G3	chr1	21329206	-	ENST00000374761	RAP1GAP	chr1	21945565	-	3283	225	168	2198	676
ENST00000264211	EIF4G3	chr1	21329206	-	ENST00000290101	RAP1GAP	chr1	21945565	-	3283	225	168	2198	676
ENST00000264211	EIF4G3	chr1	21329206	-	ENST00000374763	RAP1GAP	chr1	21945565	-	3532	225	168	2453	761
ENST00000264211	EIF4G3	chr1	21329206	-	ENST00000374765	RAP1GAP	chr1	21945565	-	3277	225	168	2198	676
ENST00000264211	EIF4G3	chr1	21329206	-	ENST00000542643	RAP1GAP	chr1	21945565	-	3330	225	168	2252	694
ENST00000374935	EIF4G3	chr1	21329206	-	ENST00000374761	RAP1GAP	chr1	21945565	-	3191	133	76	2106	676
ENST00000374935	EIF4G3	chr1	21329206	-	ENST00000290101	RAP1GAP	chr1	21945565	-	3191	133	76	2106	676
ENST00000374935	EIF4G3	chr1	21329206	-	ENST00000374763	RAP1GAP	chr1	21945565	-	3440	133	76	2361	761
ENST00000374935	EIF4G3	chr1	21329206	-	ENST00000374765	RAP1GAP	chr1	21945565	-	3185	133	76	2106	676
ENST00000374935	EIF4G3	chr1	21329206	-	ENST00000542643	RAP1GAP	chr1	21945565	-	3238	133	76	2160	694
ENST00000374937	EIF4G3	chr1	21329206	-	ENST00000374761	RAP1GAP	chr1	21945565	-	3249	191	134	2164	676
ENST00000374937	EIF4G3	chr1	21329206	-	ENST00000290101	RAP1GAP	chr1	21945565	-	3249	191	134	2164	676
ENST00000374937	EIF4G3	chr1	21329206	-	ENST00000374763	RAP1GAP	chr1	21945565	-	3498	191	134	2419	761
ENST00000374937	EIF4G3	chr1	21329206	-	ENST00000374765	RAP1GAP	chr1	21945565	-	3243	191	134	2164	676
ENST00000374937	EIF4G3	chr1	21329206	-	ENST00000542643	RAP1GAP	chr1	21945565	-	3296	191	134	2218	694
ENST00000356916	EIF4G3	chr1	21329206	-	ENST00000374761	RAP1GAP	chr1	21945565	-	3585	527	128	2500	790
ENST00000356916	EIF4G3	chr1	21329206	-	ENST00000290101	RAP1GAP	chr1	21945565	-	3585	527	128	2500	790
ENST00000356916	EIF4G3	chr1	21329206	-	ENST00000374763	RAP1GAP	chr1	21945565	-	3834	527	128	2755	875
ENST00000356916	EIF4G3	chr1	21329206	-	ENST00000374765	RAP1GAP	chr1	21945565	-	3579	527	128	2500	790
ENST00000356916	EIF4G3	chr1	21329206	-	ENST00000542643	RAP1GAP	chr1	21945565	-	3632	527	128	2554	808
ENST00000264211	EIF4G3	chr1	21329206	-	ENST00000374761	RAP1GAP	chr1	21940582	-	3010	225	168	1925	585
ENST00000264211	EIF4G3	chr1	21329206	-	ENST00000290101	RAP1GAP	chr1	21940582	-	3010	225	168	1925	585
ENST00000264211	EIF4G3	chr1	21329206	-	ENST00000374763	RAP1GAP	chr1	21940582	-	3259	225	168	2180	670
ENST00000264211	EIF4G3	chr1	21329206	-	ENST00000374765	RAP1GAP	chr1	21940582	-	3004	225	168	1925	585
ENST00000264211	EIF4G3	chr1	21329206	-	ENST00000542643	RAP1GAP	chr1	21940582	-	3057	225	168	1979	603
ENST00000374935	EIF4G3	chr1	21329206	-	ENST00000374761	RAP1GAP	chr1	21940582	-	2918	133	76	1833	585
ENST00000374935	EIF4G3	chr1	21329206	-	ENST00000290101	RAP1GAP	chr1	21940582	-	2918	133	76	1833	585
ENST00000374935	EIF4G3	chr1	21329206	-	ENST00000374763	RAP1GAP	chr1	21940582	-	3167	133	76	2088	670
ENST00000374935	EIF4G3	chr1	21329206	-	ENST00000374765	RAP1GAP	chr1	21940582	-	2912	133	76	1833	585
ENST00000374935	EIF4G3	chr1	21329206	-	ENST00000542643	RAP1GAP	chr1	21940582	-	2965	133	76	1887	603
ENST00000374937	EIF4G3	chr1	21329206	-	ENST00000374761	RAP1GAP	chr1	21940582	-	2976	191	134	1891	585
ENST00000374937	EIF4G3	chr1	21329206	-	ENST00000290101	RAP1GAP	chr1	21940582	-	2976	191	134	1891	585
ENST00000374937	EIF4G3	chr1	21329206	-	ENST00000374763	RAP1GAP	chr1	21940582	-	3225	191	134	2146	670
ENST00000374937	EIF4G3	chr1	21329206	-	ENST00000374765	RAP1GAP	chr1	21940582	-	2970	191	134	1891	585
ENST00000374937	EIF4G3	chr1	21329206	-	ENST00000542643	RAP1GAP	chr1	21940582	-	3023	191	134	1945	603
ENST00000356916	EIF4G3	chr1	21329206	-	ENST00000374761	RAP1GAP	chr1	21940582	-	3312	527	128	2227	699
ENST00000356916	EIF4G3	chr1	21329206	-	ENST00000290101	RAP1GAP	chr1	21940582	-	3312	527	128	2227	699
ENST00000356916	EIF4G3	chr1	21329206	-	ENST00000374763	RAP1GAP	chr1	21940582	-	3561	527	128	2482	784
ENST00000356916	EIF4G3	chr1	21329206	-	ENST00000374765	RAP1GAP	chr1	21940582	-	3306	527	128	2227	699
ENST00000356916	EIF4G3	chr1	21329206	-	ENST00000542643	RAP1GAP	chr1	21940582	-	3359	527	128	2281	717
ENST00000356916	EIF4G3	chr1	21324094	-	ENST00000374761	RAP1GAP	chr1	21945565	-	3618	560	128	2533	801
ENST00000356916	EIF4G3	chr1	21324094	-	ENST00000290101	RAP1GAP	chr1	21945565	-	3618	560	128	2533	801
ENST00000356916	EIF4G3	chr1	21324094	-	ENST00000374763	RAP1GAP	chr1	21945565	-	3867	560	128	2788	886
ENST00000356916	EIF4G3	chr1	21324094	-	ENST00000374765	RAP1GAP	chr1	21945565	-	3612	560	128	2533	801
ENST00000356916	EIF4G3	chr1	21324094	-	ENST00000542643	RAP1GAP	chr1	21945565	-	3665	560	128	2587	819

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264211	ENST00000374761	EIF4G3	chr1	21329205	-	RAP1GAP	chr1	21945565	-	0.01793693	0.98206306
ENST00000264211	ENST00000290101	EIF4G3	chr1	21329205	-	RAP1GAP	chr1	21945565	-	0.01793693	0.98206306
ENST00000264211	ENST00000374763	EIF4G3	chr1	21329205	-	RAP1GAP	chr1	21945565	-	0.016179653	0.9838203
ENST00000264211	ENST00000374765	EIF4G3	chr1	21329205	-	RAP1GAP	chr1	21945565	-	0.01825362	0.98174644
ENST00000264211	ENST00000542643	EIF4G3	chr1	21329205	-	RAP1GAP	chr1	21945565	-	0.017576437	0.98242354
ENST00000374935	ENST00000374761	EIF4G3	chr1	21329205	-	RAP1GAP	chr1	21945565	-	0.017691446	0.9823086
ENST00000374935	ENST00000290101	EIF4G3	chr1	21329205	-	RAP1GAP	chr1	21945565	-	0.017691446	0.9823086
ENST00000374935	ENST00000374763	EIF4G3	chr1	21329205	-	RAP1GAP	chr1	21945565	-	0.015983455	0.98401654
ENST00000374935	ENST00000374765	EIF4G3	chr1	21329205	-	RAP1GAP	chr1	21945565	-	0.01805662	0.9819434
ENST00000374935	ENST00000542643	EIF4G3	chr1	21329205	-	RAP1GAP	chr1	21945565	-	0.017397968	0.982602
ENST00000374937	ENST00000374761	EIF4G3	chr1	21329205	-	RAP1GAP	chr1	21945565	-	0.018059066	0.981941
ENST00000374937	ENST00000290101	EIF4G3	chr1	21329205	-	RAP1GAP	chr1	21945565	-	0.018059066	0.981941
ENST00000374937	ENST00000374763	EIF4G3	chr1	21329205	-	RAP1GAP	chr1	21945565	-	0.016379492	0.9836205
ENST00000374937	ENST00000374765	EIF4G3	chr1	21329205	-	RAP1GAP	chr1	21945565	-	0.01838201	0.981618
ENST00000374937	ENST00000542643	EIF4G3	chr1	21329205	-	RAP1GAP	chr1	21945565	-	0.017742116	0.9822579
ENST00000356916	ENST00000374761	EIF4G3	chr1	21329205	-	RAP1GAP	chr1	21945565	-	0.016012348	0.9839877
ENST00000356916	ENST00000290101	EIF4G3	chr1	21329205	-	RAP1GAP	chr1	21945565	-	0.016012348	0.9839877
ENST00000356916	ENST00000374763	EIF4G3	chr1	21329205	-	RAP1GAP	chr1	21945565	-	0.014662663	0.9853373
ENST00000356916	ENST00000374765	EIF4G3	chr1	21329205	-	RAP1GAP	chr1	21945565	-	0.016283754	0.98371625
ENST00000356916	ENST00000542643	EIF4G3	chr1	21329205	-	RAP1GAP	chr1	21945565	-	0.01565142	0.9843486
ENST00000264211	ENST00000374761	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21945565	-	0.01793693	0.98206306
ENST00000264211	ENST00000290101	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21945565	-	0.01793693	0.98206306
ENST00000264211	ENST00000374763	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21945565	-	0.016179653	0.9838203
ENST00000264211	ENST00000374765	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21945565	-	0.01825362	0.98174644
ENST00000264211	ENST00000542643	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21945565	-	0.017576437	0.98242354
ENST00000374935	ENST00000374761	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21945565	-	0.017691446	0.9823086
ENST00000374935	ENST00000290101	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21945565	-	0.017691446	0.9823086
ENST00000374935	ENST00000374763	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21945565	-	0.015983455	0.98401654
ENST00000374935	ENST00000374765	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21945565	-	0.01805662	0.9819434
ENST00000374935	ENST00000542643	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21945565	-	0.017397968	0.982602
ENST00000374937	ENST00000374761	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21945565	-	0.018059066	0.981941
ENST00000374937	ENST00000290101	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21945565	-	0.018059066	0.981941
ENST00000374937	ENST00000374763	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21945565	-	0.016379492	0.9836205
ENST00000374937	ENST00000374765	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21945565	-	0.01838201	0.981618
ENST00000374937	ENST00000542643	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21945565	-	0.017742116	0.9822579
ENST00000356916	ENST00000374761	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21945565	-	0.016012348	0.9839877
ENST00000356916	ENST00000290101	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21945565	-	0.016012348	0.9839877
ENST00000356916	ENST00000374763	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21945565	-	0.014662663	0.9853373
ENST00000356916	ENST00000374765	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21945565	-	0.016283754	0.98371625
ENST00000356916	ENST00000542643	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21945565	-	0.01565142	0.9843486
ENST00000264211	ENST00000374761	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21940582	-	0.010287888	0.9897121
ENST00000264211	ENST00000290101	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21940582	-	0.010287888	0.9897121
ENST00000264211	ENST00000374763	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21940582	-	0.011439647	0.9885604
ENST00000264211	ENST00000374765	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21940582	-	0.010520604	0.98947936
ENST00000264211	ENST00000542643	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21940582	-	0.010278832	0.9897211
ENST00000374935	ENST00000374761	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21940582	-	0.010049655	0.9899504
ENST00000374935	ENST00000290101	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21940582	-	0.010049655	0.9899504
ENST00000374935	ENST00000374763	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21940582	-	0.011309701	0.9886903
ENST00000374935	ENST00000374765	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21940582	-	0.010297671	0.98970234
ENST00000374935	ENST00000542643	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21940582	-	0.010134022	0.98986596
ENST00000374937	ENST00000374761	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21940582	-	0.010390325	0.9896097
ENST00000374937	ENST00000290101	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21940582	-	0.010390325	0.9896097
ENST00000374937	ENST00000374763	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21940582	-	0.011541313	0.9884587
ENST00000374937	ENST00000374765	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21940582	-	0.010580602	0.98941934
ENST00000374937	ENST00000542643	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21940582	-	0.010401352	0.98959863
ENST00000356916	ENST00000374761	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21940582	-	0.008817287	0.9911827
ENST00000356916	ENST00000290101	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21940582	-	0.008817287	0.9911827
ENST00000356916	ENST00000374763	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21940582	-	0.010225552	0.98977447
ENST00000356916	ENST00000374765	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21940582	-	0.009104556	0.99089545
ENST00000356916	ENST00000542643	EIF4G3	chr1	21329206	-	RAP1GAP	chr1	21940582	-	0.009025127	0.99097484
ENST00000356916	ENST00000374761	EIF4G3	chr1	21324094	-	RAP1GAP	chr1	21945565	-	0.011143599	0.9888564
ENST00000356916	ENST00000290101	EIF4G3	chr1	21324094	-	RAP1GAP	chr1	21945565	-	0.011143599	0.9888564
ENST00000356916	ENST00000374763	EIF4G3	chr1	21324094	-	RAP1GAP	chr1	21945565	-	0.009831999	0.990168
ENST00000356916	ENST00000374765	EIF4G3	chr1	21324094	-	RAP1GAP	chr1	21945565	-	0.011413393	0.9885866
ENST00000356916	ENST00000542643	EIF4G3	chr1	21324094	-	RAP1GAP	chr1	21945565	-	0.011007573	0.9889924

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

Top

Fusion Protein Breakpoint Sequences for EIF4G3-RAP1GAP

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
EIF4G3	chr1	21324094	RAP1GAP	chr1	21945565	560	143	RSPFAAGPRPPHHQGSRMDEQRCSFP
EIF4G3	chr1	21329205	RAP1GAP	chr1	21945565	133	19	PQTMNSQPQTRSPGSRMDEQRCSFPP
EIF4G3	chr1	21329205	RAP1GAP	chr1	21945565	191	19	PQTMNSQPQTRSPGSRMDEQRCSFPP
EIF4G3	chr1	21329205	RAP1GAP	chr1	21945565	225	19	PQTMNSQPQTRSPGSRMDEQRCSFPP
EIF4G3	chr1	21329205	RAP1GAP	chr1	21945565	527	133	PQTMNSQPQTRSPGSRMDEQRCSFPP
EIF4G3	chr1	21329206	RAP1GAP	chr1	21940582	133	19	PQTMNSQPQTRSPEHFNYYSLDAALG
EIF4G3	chr1	21329206	RAP1GAP	chr1	21940582	191	19	PQTMNSQPQTRSPEHFNYYSLDAALG
EIF4G3	chr1	21329206	RAP1GAP	chr1	21940582	225	19	PQTMNSQPQTRSPEHFNYYSLDAALG
EIF4G3	chr1	21329206	RAP1GAP	chr1	21940582	527	133	PQTMNSQPQTRSPEHFNYYSLDAALG
EIF4G3	chr1	21329206	RAP1GAP	chr1	21945565	133	19	PQTMNSQPQTRSPGSRMDEQRCSFPP
EIF4G3	chr1	21329206	RAP1GAP	chr1	21945565	191	19	PQTMNSQPQTRSPGSRMDEQRCSFPP
EIF4G3	chr1	21329206	RAP1GAP	chr1	21945565	225	19	PQTMNSQPQTRSPGSRMDEQRCSFPP
EIF4G3	chr1	21329206	RAP1GAP	chr1	21945565	527	133	PQTMNSQPQTRSPGSRMDEQRCSFPP

Top

Potential FusionNeoAntigen Information of EIF4G3-RAP1GAP in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

EIF4G3-RAP1GAP_21324094_21945565.msa
EIF4G3-RAP1GAP_21329205_21945565.msa
EIF4G3-RAP1GAP_21329206_21940582.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
EIF4G3-RAP1GAP	chr1	21324094	chr1	21945565	560	HLA-B07:02	RPPHHQGSRM	0.9968	0.6038	8	18
EIF4G3-RAP1GAP	chr1	21324094	chr1	21945565	560	HLA-B07:05	RPPHHQGSRM	0.9959	0.508	8	18
EIF4G3-RAP1GAP	chr1	21324094	chr1	21945565	560	HLA-B07:12	RPPHHQGSRM	0.9711	0.7249	8	18
EIF4G3-RAP1GAP	chr1	21324094	chr1	21945565	560	HLA-B07:04	RPPHHQGSRM	0.8186	0.5904	8	18
EIF4G3-RAP1GAP	chr1	21324094	chr1	21945565	560	HLA-B07:09	GPRPPHHQ	0.999	0.6859	6	14
EIF4G3-RAP1GAP	chr1	21324094	chr1	21945565	560	HLA-B07:09	RPPHHQGSRM	0.9968	0.6177	8	18
EIF4G3-RAP1GAP	chr1	21324094	chr1	21945565	560	HLA-B07:22	RPPHHQGSRM	0.9968	0.6038	8	18
EIF4G3-RAP1GAP	chr1	21329205	chr1	21945565	225	HLA-B15:16	QTRSPGSRM	0.8365	0.5872	8	17
EIF4G3-RAP1GAP	chr1	21329205	chr1	21945565	225	HLA-A30:08	QTRSPGSRM	0.7351	0.5685	8	17
EIF4G3-RAP1GAP	chr1	21329205	chr1	21945565	225	HLA-B81:01	QPQTRSPGSRM	0.69	0.5881	6	17
EIF4G3-RAP1GAP	chr1	21329205	chr1	21945565	225	HLA-B82:01	QPQTRSPGSRM	0.6861	0.7608	6	17
EIF4G3-RAP1GAP	chr1	21329205	chr1	21945565	225	HLA-C15:04	QTRSPGSRM	0.933	0.8404	8	17
EIF4G3-RAP1GAP	chr1	21329205	chr1	21945565	225	HLA-C12:12	QTRSPGSRM	0.7941	0.8948	8	17
EIF4G3-RAP1GAP	chr1	21329205	chr1	21945565	225	HLA-B07:12	QPQTRSPGSRM	0.9946	0.5489	6	17
EIF4G3-RAP1GAP	chr1	21329205	chr1	21945565	225	HLA-B42:02	QPQTRSPGSRM	0.9841	0.5681	6	17
EIF4G3-RAP1GAP	chr1	21329205	chr1	21945565	225	HLA-B42:01	QPQTRSPGSRM	0.9822	0.5552	6	17
EIF4G3-RAP1GAP	chr1	21329205	chr1	21945565	225	HLA-C15:09	QTRSPGSRM	0.933	0.8404	8	17
EIF4G3-RAP1GAP	chr1	21329205	chr1	21945565	225	HLA-A30:01	QTRSPGSRM	0.7552	0.7616	8	17
EIF4G3-RAP1GAP	chr1	21329205	chr1	21945565	225	HLA-B82:02	QPQTRSPGSRM	0.6861	0.7608	6	17
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B35:08	SPEHFNYY	0.9845	0.6754	11	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B27:02	TRSPEHFNY	0.999	0.7587	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B27:05	TRSPEHFNY	0.9989	0.9427	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B27:04	TRSPEHFNY	0.9988	0.8691	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:25	RSPEHFNYY	0.9927	0.8918	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:17	RSPEHFNYY	0.9922	0.8845	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B58:02	RSPEHFNYY	0.9805	0.888	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:16	RSPEHFNYY	0.9726	0.5479	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:01	RSPEHFNYY	0.9632	0.9242	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-A30:08	RSPEHFNYY	0.8025	0.7237	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-A32:13	RSPEHFNYY	0.7364	0.91	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:03	RSPEHFNYY	0.6219	0.7572	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B47:01	TRSPEHFNY	0.5576	0.6748	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:03	TRSPEHFNY	0.5339	0.8976	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:18	TRSPEHFNY	0.3523	0.8669	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B27:04	TRSPEHFNYY	0.9999	0.8149	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B27:05	TRSPEHFNYY	0.9999	0.923	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B27:02	TRSPEHFNYY	0.9999	0.6762	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B27:05	QTRSPEHFNY	0.9843	0.7814	8	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B27:04	QTRSPEHFNY	0.9782	0.5769	8	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:18	TRSPEHFNYY	0.9165	0.7873	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:95	TRSPEHFNY	0.9976	0.7466	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B27:14	TRSPEHFNY	0.9933	0.887	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:27	TRSPEHFNY	0.9925	0.9632	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B27:03	TRSPEHFNY	0.9901	0.9553	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:05	TRSPEHFNY	0.9897	0.9685	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:07	RSPEHFNYY	0.9558	0.7452	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:05	RSPEHFNYY	0.9414	0.8393	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:46	TRSPEHFNY	0.9328	0.9097	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:19	TRSPEHFNY	0.9283	0.8157	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:19	RSPEHFNYY	0.908	0.7811	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:80	TRSPEHFNY	0.9074	0.9571	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:67	TRSPEHFNY	0.9074	0.9571	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:95	RSPEHFNYY	0.8844	0.7268	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:10	TRSPEHFNY	0.8736	0.9664	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:10	RSPEHFNYY	0.8691	0.9574	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:27	RSPEHFNYY	0.863	0.9633	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:80	RSPEHFNYY	0.8616	0.9589	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:67	RSPEHFNYY	0.8616	0.9589	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:05	RSPEHFNYY	0.8454	0.9643	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C15:04	RSPEHFNYY	0.8213	0.9016	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:46	RSPEHFNYY	0.7885	0.9133	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:04	RSPEHFNYY	0.7414	0.9306	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C03:14	RSPEHFNYY	0.4687	0.9809	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C12:16	RSPEHFNYY	0.3142	0.9453	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C12:12	RSPEHFNYY	0.0439	0.8962	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C01:17	RSPEHFNYY	0.0337	0.897	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C12:16	TRSPEHFNY	0.0334	0.9472	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C12:04	RSPEHFNYY	0.0123	0.9924	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C06:03	RSPEHFNYY	0.0115	0.9917	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C01:30	RSPEHFNYY	0.0042	0.9118	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:95	TRSPEHFNYY	0.9993	0.7019	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B27:03	TRSPEHFNYY	0.999	0.9384	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:27	TRSPEHFNYY	0.9988	0.954	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:05	TRSPEHFNYY	0.9979	0.9575	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:19	TRSPEHFNYY	0.9956	0.7591	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:46	TRSPEHFNYY	0.9948	0.8838	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:80	TRSPEHFNYY	0.9924	0.9424	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:67	TRSPEHFNYY	0.9924	0.9424	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:10	TRSPEHFNYY	0.9906	0.9523	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B42:02	QPQTRSPEHF	0.9152	0.5406	6	16
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B42:01	QPQTRSPEHF	0.9121	0.5322	6	16
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B27:03	QTRSPEHFNY	0.8694	0.8184	8	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B39:10	SPEHFNYYSL	0.8389	0.8911	11	21
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C12:16	TRSPEHFNYY	0.7351	0.9282	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C01:17	RSPEHFNYYSL	0.9901	0.941	10	21
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C01:30	RSPEHFNYYSL	0.8572	0.9445	10	21
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B35:17	SPEHFNYY	0.9848	0.6095	11	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B35:30	SPEHFNYY	0.9848	0.6095	11	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B35:24	SPEHFNYY	0.9844	0.8641	11	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B35:11	SPEHFNYY	0.9834	0.8238	11	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B18:07	SPEHFNYY	0.837	0.8954	11	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B27:08	TRSPEHFNY	0.999	0.9096	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B27:10	TRSPEHFNY	0.9987	0.9293	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:01	TRSPEHFNY	0.998	0.7228	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:39	RSPEHFNYY	0.9918	0.8203	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:17	TRSPEHFNY	0.9918	0.9644	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B57:04	RSPEHFNYY	0.9888	0.6326	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B58:06	RSPEHFNYY	0.98	0.7701	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:27	RSPEHFNYY	0.9641	0.9254	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:34	RSPEHFNYY	0.9632	0.9242	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:33	RSPEHFNYY	0.9632	0.9242	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:125	RSPEHFNYY	0.9632	0.9242	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:50	RSPEHFNYY	0.9614	0.9046	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:135	RSPEHFNYY	0.9609	0.9145	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B27:09	TRSPEHFNY	0.9554	0.9305	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:35	RSPEHFNYY	0.9476	0.9113	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:20	RSPEHFNYY	0.9442	0.8819	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:22	RSPEHFNYY	0.9318	0.6991	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B35:28	RSPEHFNYY	0.9214	0.8754	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:01	RSPEHFNYY	0.9148	0.6933	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:24	RSPEHFNYY	0.9118	0.8887	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:02	TRSPEHFNY	0.9074	0.9571	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:17	RSPEHFNYY	0.8786	0.9645	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:22	TRSPEHFNY	0.8708	0.7254	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:02	RSPEHFNYY	0.8616	0.9589	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-A32:01	RSPEHFNYY	0.8361	0.9068	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C15:09	RSPEHFNYY	0.8213	0.9016	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B57:02	RSPEHFNYY	0.813	0.7845	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-A30:01	RSPEHFNYY	0.8077	0.8332	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C03:02	RSPEHFNYY	0.6627	0.9777	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B48:02	TRSPEHFNY	0.6301	0.9278	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C06:08	TRSPEHFNY	0.5665	0.9903	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C16:01	RSPEHFNYY	0.4414	0.9679	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C06:06	RSPEHFNYY	0.379	0.9867	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C16:04	RSPEHFNYY	0.3365	0.9672	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:54	RSPEHFNYY	0.29	0.8965	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C16:02	RSPEHFNYY	0.278	0.9895	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-A25:01	RSPEHFNYY	0.2501	0.768	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C14:02	RSPEHFNYY	0.1985	0.9482	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C14:03	RSPEHFNYY	0.1985	0.9482	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C06:06	TRSPEHFNY	0.1377	0.986	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:68	RSPEHFNYY	0.1258	0.6654	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C12:02	RSPEHFNYY	0.1203	0.9567	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C12:03	RSPEHFNYY	0.1191	0.9723	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:54	TRSPEHFNY	0.0285	0.9271	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C01:02	RSPEHFNYY	0.0274	0.8929	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C01:03	RSPEHFNYY	0.0256	0.842	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C06:02	RSPEHFNYY	0.0193	0.9916	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C06:17	RSPEHFNYY	0.0193	0.9916	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B15:68	TRSPEHFNY	0.0115	0.7454	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C02:02	RSPEHFNYY	0.0064	0.983	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C02:10	RSPEHFNYY	0.0064	0.983	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C06:08	RSPEHFNYY	0.0051	0.9919	10	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C06:17	TRSPEHFNY	0.0042	0.9911	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C06:02	TRSPEHFNY	0.0042	0.9911	9	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B27:10	TRSPEHFNYY	0.9999	0.9	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:01	TRSPEHFNYY	0.9992	0.6735	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:17	TRSPEHFNYY	0.9987	0.9532	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B57:04	QTRSPEHFNY	0.9985	0.7173	8	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:02	TRSPEHFNYY	0.9924	0.9424	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:22	QTRSPEHFNY	0.9839	0.6635	8	18
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C07:22	TRSPEHFNYY	0.9832	0.6793	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C06:08	TRSPEHFNYY	0.9613	0.987	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-B67:01	SPEHFNYYSL	0.8407	0.7725	11	21
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C06:17	TRSPEHFNYY	0.6429	0.9886	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C06:02	TRSPEHFNYY	0.6429	0.9886	9	19
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C01:02	RSPEHFNYYSL	0.9913	0.9386	10	21
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	225	HLA-C01:03	RSPEHFNYYSL	0.9911	0.9222	10	21

Top

Potential FusionNeoAntigen Information of EIF4G3-RAP1GAP in HLA II

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene

Hchr

Hbp

Tgene

Tchr

Tbp

HLA II

FusionNeoAntigen peptide

Neoantigen start (at BP 13)

Neoantigen end (at BP 13)

Top

Fusion breakpoint peptide structures of EIF4G3-RAP1GAP

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
3036	GPRPPHHQGSRMDE	EIF4G3	RAP1GAP	chr1	21324094	chr1	21945565	560

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
7475	QPQTRSPEHFNYYS	EIF4G3	RAP1GAP	chr1	21329206	chr1	21940582	225

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
7476	QPQTRSPGSRMDEQ	EIF4G3	RAP1GAP	chr1	21329205	chr1	21945565	225

Top

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of EIF4G3-RAP1GAP

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	3036	GPRPPHHQGSRMDE	-7.9962	-8.1096
HLA-B14:02	3BVN	3036	GPRPPHHQGSRMDE	-5.70842	-6.74372
HLA-B52:01	3W39	3036	GPRPPHHQGSRMDE	-6.83737	-6.95077
HLA-B52:01	3W39	3036	GPRPPHHQGSRMDE	-4.4836	-5.5189
HLA-A11:01	4UQ2	3036	GPRPPHHQGSRMDE	-10.0067	-10.1201
HLA-A11:01	4UQ2	3036	GPRPPHHQGSRMDE	-9.03915	-10.0745
HLA-A24:02	5HGA	3036	GPRPPHHQGSRMDE	-6.56204	-6.67544
HLA-A24:02	5HGA	3036	GPRPPHHQGSRMDE	-5.42271	-6.45801
HLA-B44:05	3DX8	3036	GPRPPHHQGSRMDE	-7.85648	-8.89178
HLA-B44:05	3DX8	3036	GPRPPHHQGSRMDE	-5.3978	-5.5112
HLA-A02:01	6TDR	3036	GPRPPHHQGSRMDE	-3.37154	-4.40684
HLA-B14:02	3BVN	7475	QPQTRSPEHFNYYS	-7.9962	-8.1096
HLA-B14:02	3BVN	7475	QPQTRSPEHFNYYS	-5.70842	-6.74372
HLA-B52:01	3W39	7475	QPQTRSPEHFNYYS	-6.83737	-6.95077
HLA-B52:01	3W39	7475	QPQTRSPEHFNYYS	-4.4836	-5.5189
HLA-A11:01	4UQ2	7475	QPQTRSPEHFNYYS	-10.0067	-10.1201
HLA-A11:01	4UQ2	7475	QPQTRSPEHFNYYS	-9.03915	-10.0745
HLA-A24:02	5HGA	7475	QPQTRSPEHFNYYS	-6.56204	-6.67544
HLA-A24:02	5HGA	7475	QPQTRSPEHFNYYS	-5.42271	-6.45801
HLA-B44:05	3DX8	7475	QPQTRSPEHFNYYS	-7.85648	-8.89178
HLA-B44:05	3DX8	7475	QPQTRSPEHFNYYS	-5.3978	-5.5112
HLA-A02:01	6TDR	7475	QPQTRSPEHFNYYS	-3.37154	-4.40684
HLA-B14:02	3BVN	7476	QPQTRSPGSRMDEQ	-5.6364	-5.6364
HLA-A24:02	5HGA	7476	QPQTRSPGSRMDEQ	-9.18993	-9.18993

Top

Vaccine Design for the FusionNeoAntigens of EIF4G3-RAP1GAP

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
EIF4G3-RAP1GAP	chr1	21324094	chr1	21945565	6	14	GPRPPHHQ	CCTCGACCTCCCCATCATCAGGGA
EIF4G3-RAP1GAP	chr1	21324094	chr1	21945565	8	18	RPPHHQGSRM	CCTCCCCATCATCAGGGAAGCAGGATGGAT
EIF4G3-RAP1GAP	chr1	21329205	chr1	21945565	6	17	QPQTRSPGSRM	CAACCTCAAACCCGTTCTCCGGGAAGCAGGATG
EIF4G3-RAP1GAP	chr1	21329205	chr1	21945565	8	17	QTRSPGSRM	CAAACCCGTTCTCCGGGAAGCAGGATG
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	10	19	RSPEHFNYY	CGTTCTCCGGAGCATTTCAATTACTAC
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	10	21	RSPEHFNYYSL	CGTTCTCCGGAGCATTTCAATTACTACTCACTG
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	11	19	SPEHFNYY	TCTCCGGAGCATTTCAATTACTAC
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	11	21	SPEHFNYYSL	TCTCCGGAGCATTTCAATTACTACTCACTG
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	6	16	QPQTRSPEHF	CAACCTCAAACCCGTTCTCCGGAGCATTTC
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	8	18	QTRSPEHFNY	CAAACCCGTTCTCCGGAGCATTTCAATTAC
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	9	18	TRSPEHFNY	ACCCGTTCTCCGGAGCATTTCAATTAC
EIF4G3-RAP1GAP	chr1	21329206	chr1	21940582	9	19	TRSPEHFNYY	ACCCGTTCTCCGGAGCATTTCAATTACTAC

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene

Hchr

Hbp

Tchr

Tbp

Start in +/-13AA

End in +/-13AA

FusionNeoAntigen peptide

FusionNEoAntigen RNA sequence

Top

Information of the samples that have these potential fusion neoantigens of EIF4G3-RAP1GAP

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
BRCA	EIF4G3-RAP1GAP	chr1	21329206	ENST00000264211	chr1	21940582	ENST00000290101	TCGA-AN-A0FJ-01A
BRCA	EIF4G3-RAP1GAP	chr1	21329205	ENST00000264211	chr1	21945565	ENST00000290101	TCGA-AN-A0FJ
BRCA	EIF4G3-RAP1GAP	chr1	21324094	ENST00000356916	chr1	21945565	ENST00000290101	TCGA-AN-A0FJ-01A

Top

Potential target of CAR-T therapy development for EIF4G3-RAP1GAP

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

Top

Related Drugs to EIF4G3-RAP1GAP

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to EIF4G3-RAP1GAP

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)