Home

Download

Statistics

Examples

Help

Contact

Fusion Protein:ERC1-WNK1

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ERC1-WNK1
	FusionPDB ID: 27286
	FusionGDB2.0 ID: 27286
		Hgene	Tgene
	Gene symbol	ERC1	WNK1
	Gene ID	23085	65125
	Gene name	ELKS/RAB6-interacting/CAST family member 1	WNK lysine deficient protein kinase 1
	Synonyms	Cast2\|ELKS\|ERC-1\|RAB6IP2	HSAN2\|HSN2\|KDP\|PPP1R167\|PRKWNK1\|PSK\|p65
	Cytomap	12p13.33	12p13.33
	Type of gene	protein-coding	protein-coding
	Description	ELKS/Rab6-interacting/CAST family member 1RAB6 interacting protein 2	serine/threonine-protein kinase WNK1WNK lysine deficient protein kinase 1 isoformerythrocyte 65 kDa proteinprostate-derived sterile 20-like kinaseprotein kinase with no lysine 1protein phosphatase 1, regulatory subunit 167serine/threonine-protein ki
	Modification date	20200313	20200327
	UniProtAcc	Q8IUD2 Main function of 5'-partner protein: FUNCTION: Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269\|PubMed:15218148}.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000536573, ENST00000355446, ENST00000360905, ENST00000397203, ENST00000543086, ENST00000546231, ENST00000589028,	ENST00000315939, ENST00000535572, ENST00000537687, ENST00000340908, ENST00000447667, ENST00000530271, ENST00000540360, ENST00000574564,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	32 X 23 X 16=11776	13 X 15 X 6=1170
	# samples	38	14
	** MAII score	log2(38/11776*10)=-4.95370634772607 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/1170*10)=-3.0630097975258 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: ERC1 [Title/Abstract] AND WNK1 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: ERC1 [Title/Abstract] AND WNK1 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ERC1(1213990)-WNK1(987377), # samples:2 ERC1(1213990)-WNK1(977032), # samples:2 ERC1(1137738)-WNK1(987378), # samples:2 WNK1(922980)-ERC1(1289705), # samples:2
Anticipated loss of major functional domain due to fusion event.	WNK1-ERC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. WNK1-ERC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ERC1-WNK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ERC1-WNK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ERC1-WNK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ERC1-WNK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. WNK1-ERC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. WNK1-ERC1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. WNK1-ERC1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. WNK1-ERC1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. WNK1-ERC1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ERC1	GO:0007252	I-kappaB phosphorylation	15218148
Tgene	WNK1	GO:0006468	protein phosphorylation	10660600
Tgene	WNK1	GO:0010923	negative regulation of phosphatase activity	19389623
Tgene	WNK1	GO:0023016	signal transduction by trans-phosphorylation	16669787
Tgene	WNK1	GO:0035556	intracellular signal transduction	10660600

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:1213990/chr12:987377)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across ERC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across WNK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000543086	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	987377	+	8122	1432	271	5613	1780
ENST00000543086	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	987377	+	8559	1432	271	5898	1875
ENST00000543086	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	987377	+	9018	1432	271	6357	2028
ENST00000546231	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	987377	+	8379	1689	528	5870	1780
ENST00000546231	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	987377	+	8816	1689	528	6155	1875
ENST00000546231	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	987377	+	9275	1689	528	6614	2028
ENST00000397203	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	987377	+	8257	1567	406	5748	1780
ENST00000397203	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	987377	+	8694	1567	406	6033	1875
ENST00000397203	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	987377	+	9153	1567	406	6492	2028
ENST00000360905	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	987377	+	8032	1342	181	5523	1780
ENST00000360905	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	987377	+	8469	1342	181	5808	1875
ENST00000360905	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	987377	+	8928	1342	181	6267	2028
ENST00000589028	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	987377	+	8008	1318	157	5499	1780
ENST00000589028	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	987377	+	8445	1318	157	5784	1875
ENST00000589028	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	987377	+	8904	1318	157	6243	2028
ENST00000355446	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	987377	+	7983	1293	132	5474	1780
ENST00000355446	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	987377	+	8420	1293	132	5759	1875
ENST00000355446	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	987377	+	8879	1293	132	6218	2028
ENST00000543086	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	987378	+	8122	1432	271	5613	1780
ENST00000543086	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	987378	+	8559	1432	271	5898	1875
ENST00000543086	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	987378	+	9018	1432	271	6357	2028
ENST00000546231	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	987378	+	8379	1689	528	5870	1780
ENST00000546231	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	987378	+	8816	1689	528	6155	1875
ENST00000546231	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	987378	+	9275	1689	528	6614	2028
ENST00000397203	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	987378	+	8257	1567	406	5748	1780
ENST00000397203	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	987378	+	8694	1567	406	6033	1875
ENST00000397203	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	987378	+	9153	1567	406	6492	2028
ENST00000360905	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	987378	+	8032	1342	181	5523	1780
ENST00000360905	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	987378	+	8469	1342	181	5808	1875
ENST00000360905	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	987378	+	8928	1342	181	6267	2028
ENST00000589028	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	987378	+	8008	1318	157	5499	1780
ENST00000589028	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	987378	+	8445	1318	157	5784	1875
ENST00000589028	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	987378	+	8904	1318	157	6243	2028
ENST00000355446	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	987378	+	7983	1293	132	5474	1780
ENST00000355446	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	987378	+	8420	1293	132	5759	1875
ENST00000355446	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	987378	+	8879	1293	132	6218	2028
ENST00000543086	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	980431	+	8206	1432	271	5697	1808
ENST00000543086	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	980431	+	8643	1432	271	5982	1903
ENST00000543086	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	980431	+	9102	1432	271	6441	2056
ENST00000546231	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	980431	+	8463	1689	528	5954	1808
ENST00000546231	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	980431	+	8900	1689	528	6239	1903
ENST00000546231	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	980431	+	9359	1689	528	6698	2056
ENST00000397203	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	980431	+	8341	1567	406	5832	1808
ENST00000397203	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	980431	+	8778	1567	406	6117	1903
ENST00000397203	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	980431	+	9237	1567	406	6576	2056
ENST00000360905	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	980431	+	8116	1342	181	5607	1808
ENST00000360905	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	980431	+	8553	1342	181	5892	1903
ENST00000360905	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	980431	+	9012	1342	181	6351	2056
ENST00000589028	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	980431	+	8092	1318	157	5583	1808
ENST00000589028	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	980431	+	8529	1318	157	5868	1903
ENST00000589028	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	980431	+	8988	1318	157	6327	2056
ENST00000355446	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	980431	+	8067	1293	132	5558	1808
ENST00000355446	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	980431	+	8504	1293	132	5843	1903
ENST00000355446	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	980431	+	8963	1293	132	6302	2056
ENST00000543086	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	987381	+	8122	1432	271	5613	1780
ENST00000543086	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	987381	+	8559	1432	271	5898	1875
ENST00000543086	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	987381	+	9018	1432	271	6357	2028
ENST00000546231	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	987381	+	8379	1689	528	5870	1780
ENST00000546231	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	987381	+	8816	1689	528	6155	1875
ENST00000546231	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	987381	+	9275	1689	528	6614	2028
ENST00000397203	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	987381	+	8257	1567	406	5748	1780
ENST00000397203	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	987381	+	8694	1567	406	6033	1875
ENST00000397203	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	987381	+	9153	1567	406	6492	2028
ENST00000360905	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	987381	+	8032	1342	181	5523	1780
ENST00000360905	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	987381	+	8469	1342	181	5808	1875
ENST00000360905	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	987381	+	8928	1342	181	6267	2028
ENST00000589028	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	987381	+	8008	1318	157	5499	1780
ENST00000589028	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	987381	+	8445	1318	157	5784	1875
ENST00000589028	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	987381	+	8904	1318	157	6243	2028
ENST00000355446	ERC1	chr12	1213990	+	ENST00000535572	WNK1	chr12	987381	+	7983	1293	132	5474	1780
ENST00000355446	ERC1	chr12	1213990	+	ENST00000537687	WNK1	chr12	987381	+	8420	1293	132	5759	1875
ENST00000355446	ERC1	chr12	1213990	+	ENST00000315939	WNK1	chr12	987381	+	8879	1293	132	6218	2028
ENST00000543086	ERC1	chr12	1137738	+	ENST00000535572	WNK1	chr12	987378	+	7630	940	271	5121	1616
ENST00000543086	ERC1	chr12	1137738	+	ENST00000537687	WNK1	chr12	987378	+	8067	940	271	5406	1711
ENST00000543086	ERC1	chr12	1137738	+	ENST00000315939	WNK1	chr12	987378	+	8526	940	271	5865	1864
ENST00000546231	ERC1	chr12	1137738	+	ENST00000535572	WNK1	chr12	987378	+	7887	1197	528	5378	1616
ENST00000546231	ERC1	chr12	1137738	+	ENST00000537687	WNK1	chr12	987378	+	8324	1197	528	5663	1711
ENST00000546231	ERC1	chr12	1137738	+	ENST00000315939	WNK1	chr12	987378	+	8783	1197	528	6122	1864
ENST00000397203	ERC1	chr12	1137738	+	ENST00000535572	WNK1	chr12	987378	+	7765	1075	406	5256	1616
ENST00000397203	ERC1	chr12	1137738	+	ENST00000537687	WNK1	chr12	987378	+	8202	1075	406	5541	1711
ENST00000397203	ERC1	chr12	1137738	+	ENST00000315939	WNK1	chr12	987378	+	8661	1075	406	6000	1864
ENST00000360905	ERC1	chr12	1137738	+	ENST00000535572	WNK1	chr12	987378	+	7540	850	181	5031	1616
ENST00000360905	ERC1	chr12	1137738	+	ENST00000537687	WNK1	chr12	987378	+	7977	850	181	5316	1711
ENST00000360905	ERC1	chr12	1137738	+	ENST00000315939	WNK1	chr12	987378	+	8436	850	181	5775	1864
ENST00000589028	ERC1	chr12	1137738	+	ENST00000535572	WNK1	chr12	987378	+	7516	826	157	5007	1616
ENST00000589028	ERC1	chr12	1137738	+	ENST00000537687	WNK1	chr12	987378	+	7953	826	157	5292	1711
ENST00000589028	ERC1	chr12	1137738	+	ENST00000315939	WNK1	chr12	987378	+	8412	826	157	5751	1864
ENST00000355446	ERC1	chr12	1137738	+	ENST00000535572	WNK1	chr12	987378	+	7491	801	132	4982	1616
ENST00000355446	ERC1	chr12	1137738	+	ENST00000537687	WNK1	chr12	987378	+	7928	801	132	5267	1711
ENST00000355446	ERC1	chr12	1137738	+	ENST00000315939	WNK1	chr12	987378	+	8387	801	132	5726	1864

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000543086	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	987377	+	0.001557155	0.9984428
ENST00000543086	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	987377	+	0.001382491	0.99861753
ENST00000543086	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	987377	+	0.001466111	0.99853384
ENST00000546231	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	987377	+	0.002107788	0.9978922
ENST00000546231	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	987377	+	0.001887879	0.9981121
ENST00000546231	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	987377	+	0.001971904	0.9980281
ENST00000397203	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	987377	+	0.001815082	0.99818486
ENST00000397203	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	987377	+	0.001625688	0.99837434
ENST00000397203	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	987377	+	0.001702041	0.998298
ENST00000360905	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	987377	+	0.001410841	0.9985891
ENST00000360905	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	987377	+	0.001246799	0.9987532
ENST00000360905	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	987377	+	0.001318463	0.9986815
ENST00000589028	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	987377	+	0.001335977	0.998664
ENST00000589028	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	987377	+	0.001182514	0.9988175
ENST00000589028	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	987377	+	0.001249048	0.9987509
ENST00000355446	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	987377	+	0.001328571	0.9986714
ENST00000355446	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	987377	+	0.001172986	0.99882704
ENST00000355446	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	987377	+	0.001236453	0.99876356
ENST00000543086	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	987378	+	0.001557155	0.9984428
ENST00000543086	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	987378	+	0.001382491	0.99861753
ENST00000543086	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	987378	+	0.001466111	0.99853384
ENST00000546231	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	987378	+	0.002107788	0.9978922
ENST00000546231	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	987378	+	0.001887879	0.9981121
ENST00000546231	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	987378	+	0.001971904	0.9980281
ENST00000397203	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	987378	+	0.001815082	0.99818486
ENST00000397203	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	987378	+	0.001625688	0.99837434
ENST00000397203	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	987378	+	0.001702041	0.998298
ENST00000360905	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	987378	+	0.001410841	0.9985891
ENST00000360905	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	987378	+	0.001246799	0.9987532
ENST00000360905	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	987378	+	0.001318463	0.9986815
ENST00000589028	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	987378	+	0.001335977	0.998664
ENST00000589028	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	987378	+	0.001182514	0.9988175
ENST00000589028	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	987378	+	0.001249048	0.9987509
ENST00000355446	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	987378	+	0.001328571	0.9986714
ENST00000355446	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	987378	+	0.001172986	0.99882704
ENST00000355446	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	987378	+	0.001236453	0.99876356
ENST00000543086	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	980431	+	0.001608636	0.99839133
ENST00000543086	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	980431	+	0.001419617	0.99858034
ENST00000543086	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	980431	+	0.001509744	0.9984902
ENST00000546231	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	980431	+	0.002165287	0.99783474
ENST00000546231	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	980431	+	0.001932037	0.99806803
ENST00000546231	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	980431	+	0.002029042	0.997971
ENST00000397203	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	980431	+	0.001864036	0.9981359
ENST00000397203	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	980431	+	0.001664495	0.99833554
ENST00000397203	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	980431	+	0.001750059	0.99824995
ENST00000360905	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	980431	+	0.001460474	0.99853957
ENST00000360905	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	980431	+	0.001285844	0.9987142
ENST00000360905	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	980431	+	0.001354662	0.99864537
ENST00000589028	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	980431	+	0.001379873	0.99862015
ENST00000589028	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	980431	+	0.001218118	0.99878186
ENST00000589028	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	980431	+	0.001283705	0.99871635
ENST00000355446	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	980431	+	0.001372736	0.9986273
ENST00000355446	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	980431	+	0.00120819	0.9987919
ENST00000355446	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	980431	+	0.001270191	0.99872977
ENST00000543086	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	987381	+	0.001557155	0.9984428
ENST00000543086	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	987381	+	0.001382491	0.99861753
ENST00000543086	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	987381	+	0.001466111	0.99853384
ENST00000546231	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	987381	+	0.002107788	0.9978922
ENST00000546231	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	987381	+	0.001887879	0.9981121
ENST00000546231	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	987381	+	0.001971904	0.9980281
ENST00000397203	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	987381	+	0.001815082	0.99818486
ENST00000397203	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	987381	+	0.001625688	0.99837434
ENST00000397203	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	987381	+	0.001702041	0.998298
ENST00000360905	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	987381	+	0.001410841	0.9985891
ENST00000360905	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	987381	+	0.001246799	0.9987532
ENST00000360905	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	987381	+	0.001318463	0.9986815
ENST00000589028	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	987381	+	0.001335977	0.998664
ENST00000589028	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	987381	+	0.001182514	0.9988175
ENST00000589028	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	987381	+	0.001249048	0.9987509
ENST00000355446	ENST00000535572	ERC1	chr12	1213990	+	WNK1	chr12	987381	+	0.001328571	0.9986714
ENST00000355446	ENST00000537687	ERC1	chr12	1213990	+	WNK1	chr12	987381	+	0.001172986	0.99882704
ENST00000355446	ENST00000315939	ERC1	chr12	1213990	+	WNK1	chr12	987381	+	0.001236453	0.99876356
ENST00000543086	ENST00000535572	ERC1	chr12	1137738	+	WNK1	chr12	987378	+	0.00120706	0.9987929
ENST00000543086	ENST00000537687	ERC1	chr12	1137738	+	WNK1	chr12	987378	+	0.001052062	0.9989479
ENST00000543086	ENST00000315939	ERC1	chr12	1137738	+	WNK1	chr12	987378	+	0.00114341	0.99885654
ENST00000546231	ENST00000535572	ERC1	chr12	1137738	+	WNK1	chr12	987378	+	0.001668961	0.998331
ENST00000546231	ENST00000537687	ERC1	chr12	1137738	+	WNK1	chr12	987378	+	0.001457566	0.9985424
ENST00000546231	ENST00000315939	ERC1	chr12	1137738	+	WNK1	chr12	987378	+	0.001573235	0.9984268
ENST00000397203	ENST00000535572	ERC1	chr12	1137738	+	WNK1	chr12	987378	+	0.001435779	0.9985642
ENST00000397203	ENST00000537687	ERC1	chr12	1137738	+	WNK1	chr12	987378	+	0.001254248	0.9987457
ENST00000397203	ENST00000315939	ERC1	chr12	1137738	+	WNK1	chr12	987378	+	0.001351373	0.9986487
ENST00000360905	ENST00000535572	ERC1	chr12	1137738	+	WNK1	chr12	987378	+	0.001095434	0.9989046
ENST00000360905	ENST00000537687	ERC1	chr12	1137738	+	WNK1	chr12	987378	+	0.000951551	0.9990484
ENST00000360905	ENST00000315939	ERC1	chr12	1137738	+	WNK1	chr12	987378	+	0.001031966	0.998968
ENST00000589028	ENST00000535572	ERC1	chr12	1137738	+	WNK1	chr12	987378	+	0.001040279	0.99895966
ENST00000589028	ENST00000537687	ERC1	chr12	1137738	+	WNK1	chr12	987378	+	0.000905418	0.9990946
ENST00000589028	ENST00000315939	ERC1	chr12	1137738	+	WNK1	chr12	987378	+	0.00098233	0.9990177
ENST00000355446	ENST00000535572	ERC1	chr12	1137738	+	WNK1	chr12	987378	+	0.001031404	0.9989686
ENST00000355446	ENST00000537687	ERC1	chr12	1137738	+	WNK1	chr12	987378	+	0.000896114	0.99910384
ENST00000355446	ENST00000315939	ERC1	chr12	1137738	+	WNK1	chr12	987378	+	0.000971684	0.9990283

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

Top

Fusion Protein Breakpoint Sequences for ERC1-WNK1

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
ERC1	chr12	1137738	WNK1	chr12	987378	1075	222	IWKEQYRVVQEENQQGIQQTAPPQQT
ERC1	chr12	1137738	WNK1	chr12	987378	1075	223	WKEQYRVVQEENQQQGIQQTAPPQQT
ERC1	chr12	1137738	WNK1	chr12	987378	1197	222	IWKEQYRVVQEENQQGIQQTAPPQQT
ERC1	chr12	1137738	WNK1	chr12	987378	1197	223	WKEQYRVVQEENQQQGIQQTAPPQQT
ERC1	chr12	1137738	WNK1	chr12	987378	801	222	IWKEQYRVVQEENQQGIQQTAPPQQT
ERC1	chr12	1137738	WNK1	chr12	987378	801	223	WKEQYRVVQEENQQQGIQQTAPPQQT
ERC1	chr12	1137738	WNK1	chr12	987378	826	222	IWKEQYRVVQEENQQGIQQTAPPQQT
ERC1	chr12	1137738	WNK1	chr12	987378	826	223	WKEQYRVVQEENQQQGIQQTAPPQQT
ERC1	chr12	1137738	WNK1	chr12	987378	850	222	IWKEQYRVVQEENQQGIQQTAPPQQT
ERC1	chr12	1137738	WNK1	chr12	987378	850	223	WKEQYRVVQEENQQQGIQQTAPPQQT
ERC1	chr12	1137738	WNK1	chr12	987378	940	222	IWKEQYRVVQEENQQGIQQTAPPQQT
ERC1	chr12	1137738	WNK1	chr12	987378	940	223	WKEQYRVVQEENQQQGIQQTAPPQQT
ERC1	chr12	1213990	WNK1	chr12	980431	1293	387	AKTKALQTVIEMKAQGQSQGQPSSSS
ERC1	chr12	1213990	WNK1	chr12	980431	1318	387	AKTKALQTVIEMKAQGQSQGQPSSSS
ERC1	chr12	1213990	WNK1	chr12	980431	1342	387	AKTKALQTVIEMKAQGQSQGQPSSSS
ERC1	chr12	1213990	WNK1	chr12	980431	1432	387	AKTKALQTVIEMKAQGQSQGQPSSSS
ERC1	chr12	1213990	WNK1	chr12	980431	1567	387	AKTKALQTVIEMKAQGQSQGQPSSSS
ERC1	chr12	1213990	WNK1	chr12	980431	1689	387	AKTKALQTVIEMKAQGQSQGQPSSSS
ERC1	chr12	1213990	WNK1	chr12	987377	1293	387	AKTKALQTVIEMKQGIQQTAPPQQTV
ERC1	chr12	1213990	WNK1	chr12	987377	1293	387	AKTKALQTVIEMKQQGIQQTAPPQQT
ERC1	chr12	1213990	WNK1	chr12	987377	1318	387	AKTKALQTVIEMKQGIQQTAPPQQTV
ERC1	chr12	1213990	WNK1	chr12	987377	1318	387	AKTKALQTVIEMKQQGIQQTAPPQQT
ERC1	chr12	1213990	WNK1	chr12	987377	1342	387	AKTKALQTVIEMKQGIQQTAPPQQTV
ERC1	chr12	1213990	WNK1	chr12	987377	1342	387	AKTKALQTVIEMKQQGIQQTAPPQQT
ERC1	chr12	1213990	WNK1	chr12	987377	1432	387	AKTKALQTVIEMKQGIQQTAPPQQTV
ERC1	chr12	1213990	WNK1	chr12	987377	1432	387	AKTKALQTVIEMKQQGIQQTAPPQQT
ERC1	chr12	1213990	WNK1	chr12	987377	1567	387	AKTKALQTVIEMKQGIQQTAPPQQTV
ERC1	chr12	1213990	WNK1	chr12	987377	1567	387	AKTKALQTVIEMKQQGIQQTAPPQQT
ERC1	chr12	1213990	WNK1	chr12	987377	1689	387	AKTKALQTVIEMKQGIQQTAPPQQTV
ERC1	chr12	1213990	WNK1	chr12	987377	1689	387	AKTKALQTVIEMKQQGIQQTAPPQQT
ERC1	chr12	1213990	WNK1	chr12	987378	1293	387	AKTKALQTVIEMKQGIQQTAPPQQTV
ERC1	chr12	1213990	WNK1	chr12	987378	1293	387	AKTKALQTVIEMKQQGIQQTAPPQQT
ERC1	chr12	1213990	WNK1	chr12	987378	1318	387	AKTKALQTVIEMKQGIQQTAPPQQTV
ERC1	chr12	1213990	WNK1	chr12	987378	1318	387	AKTKALQTVIEMKQQGIQQTAPPQQT
ERC1	chr12	1213990	WNK1	chr12	987378	1342	387	AKTKALQTVIEMKQGIQQTAPPQQTV
ERC1	chr12	1213990	WNK1	chr12	987378	1342	387	AKTKALQTVIEMKQQGIQQTAPPQQT
ERC1	chr12	1213990	WNK1	chr12	987378	1432	387	AKTKALQTVIEMKQGIQQTAPPQQTV
ERC1	chr12	1213990	WNK1	chr12	987378	1432	387	AKTKALQTVIEMKQQGIQQTAPPQQT
ERC1	chr12	1213990	WNK1	chr12	987378	1567	387	AKTKALQTVIEMKQGIQQTAPPQQTV
ERC1	chr12	1213990	WNK1	chr12	987378	1567	387	AKTKALQTVIEMKQQGIQQTAPPQQT
ERC1	chr12	1213990	WNK1	chr12	987378	1689	387	AKTKALQTVIEMKQGIQQTAPPQQTV
ERC1	chr12	1213990	WNK1	chr12	987378	1689	387	AKTKALQTVIEMKQQGIQQTAPPQQT
ERC1	chr12	1213990	WNK1	chr12	987381	1293	387	AKTKALQTVIEMKQGIQQTAPPQQTV
ERC1	chr12	1213990	WNK1	chr12	987381	1293	387	AKTKALQTVIEMKQQGIQQTAPPQQT
ERC1	chr12	1213990	WNK1	chr12	987381	1318	387	AKTKALQTVIEMKQGIQQTAPPQQTV
ERC1	chr12	1213990	WNK1	chr12	987381	1318	387	AKTKALQTVIEMKQQGIQQTAPPQQT
ERC1	chr12	1213990	WNK1	chr12	987381	1342	387	AKTKALQTVIEMKQGIQQTAPPQQTV
ERC1	chr12	1213990	WNK1	chr12	987381	1342	387	AKTKALQTVIEMKQQGIQQTAPPQQT
ERC1	chr12	1213990	WNK1	chr12	987381	1432	387	AKTKALQTVIEMKQGIQQTAPPQQTV
ERC1	chr12	1213990	WNK1	chr12	987381	1432	387	AKTKALQTVIEMKQQGIQQTAPPQQT
ERC1	chr12	1213990	WNK1	chr12	987381	1567	387	AKTKALQTVIEMKQGIQQTAPPQQTV
ERC1	chr12	1213990	WNK1	chr12	987381	1567	387	AKTKALQTVIEMKQQGIQQTAPPQQT
ERC1	chr12	1213990	WNK1	chr12	987381	1689	387	AKTKALQTVIEMKQGIQQTAPPQQTV
ERC1	chr12	1213990	WNK1	chr12	987381	1689	387	AKTKALQTVIEMKQQGIQQTAPPQQT

Top

Potential FusionNeoAntigen Information of ERC1-WNK1 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

ERC1-WNK1_1137738_987378.msa
ERC1-WNK1_1213990_987377.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B45:01	QEENQQQGI	0.9497	0.93	8	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B44:03	QEENQQQGI	0.9355	0.9384	8	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B39:06	NQQGIQQTA	0.7296	0.9656	12	21
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B50:02	QQQGIQQTA	0.7229	0.9397	12	21
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B39:06	QQQGIQQTA	0.6857	0.9483	12	21
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B50:01	NQQGIQQTA	0.5783	0.8297	12	21
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B50:01	QQQGIQQTA	0.5467	0.9726	12	21
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B13:02	VQEENQQGI	0.5379	0.6923	8	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B13:01	VQEENQQGI	0.3921	0.9392	8	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B13:02	QQQGIQQTA	0.3791	0.9868	12	21
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B39:13	QQQGIQQTA	0.2473	0.9913	12	21
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B39:13	VQEENQQGI	0.0828	0.9269	8	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B45:01	EENQQGIQQT	0.8648	0.9284	10	20
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B45:01	EENQQGIQQTA	0.9983	0.9123	10	21
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B50:02	EENQQGIQQTA	0.9949	0.749	10	21
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B41:01	EENQQGIQQTA	0.9425	0.9113	10	21
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B73:01	NQQGIQQTA	0.8089	0.8984	12	21
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B15:04	QQQGIQQTA	0.5319	0.9318	12	21
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B39:08	QEENQQQGI	0.3637	0.9062	8	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B39:08	VQEENQQGI	0.1937	0.8403	8	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B44:07	QEENQQQGI	0.9355	0.9384	8	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B44:13	QEENQQQGI	0.9355	0.9384	8	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B44:26	QEENQQQGI	0.9355	0.9384	8	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B50:05	NQQGIQQTA	0.5783	0.8297	12	21
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B50:04	NQQGIQQTA	0.5783	0.8297	12	21
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B50:04	QQQGIQQTA	0.5467	0.9726	12	21
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B50:05	QQQGIQQTA	0.5467	0.9726	12	21
ERC1-WNK1	chr12	1137738	chr12	987378	801	HLA-B41:03	QEENQQQGI	0.4571	0.7165	8	17
ERC1-WNK1	chr12	1213990	chr12	987377	1293	HLA-B39:06	MKQGIQQTA	0.9948	0.9275	11	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	HLA-B48:01	KQQGIQQTA	0.8673	0.8562	12	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	HLA-B08:09	EMKQGIQQT	0.6614	0.8037	10	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	HLA-B13:02	KQQGIQQTA	0.5234	0.9827	12	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	HLA-B50:01	KQQGIQQTA	0.3707	0.9138	12	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	HLA-B39:13	KQQGIQQTA	0.1776	0.987	12	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	HLA-B50:02	IEMKQGIQQTA	0.9976	0.6492	9	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	HLA-B45:01	IEMKQGIQQTA	0.997	0.8827	9	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	HLA-B41:01	IEMKQGIQQTA	0.9823	0.9801	9	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	HLA-B50:01	IEMKQGIQQTA	0.9803	0.8115	9	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	HLA-B73:01	MKQGIQQTA	0.8833	0.889	11	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	HLA-B15:04	KQQGIQQTA	0.6098	0.9486	12	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	HLA-B40:06	IEMKQGIQQTA	0.9997	0.6277	9	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	HLA-A68:02	TVIEMKQGI	0.992	0.6019	7	16
ERC1-WNK1	chr12	1213990	chr12	987377	1293	HLA-A69:01	TVIEMKQGI	0.9791	0.6737	7	16
ERC1-WNK1	chr12	1213990	chr12	987377	1293	HLA-B15:73	KQQGIQQTA	0.5047	0.9898	12	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	HLA-B50:05	KQQGIQQTA	0.3707	0.9138	12	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	HLA-B50:04	KQQGIQQTA	0.3707	0.9138	12	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	HLA-B39:02	KQQGIQQTA	0.2479	0.9857	12	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	HLA-B50:05	IEMKQGIQQTA	0.9803	0.8115	9	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	HLA-B50:04	IEMKQGIQQTA	0.9803	0.8115	9	20

Top

Potential FusionNeoAntigen Information of ERC1-WNK1 in HLA II

ERC1-WNK1_1137738_987378.msa
ERC1-WNK1_1213990_980431.msa
ERC1-WNK1_1213990_987377.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0401	QYRVVQEENQQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0401	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0401	EQYRVVQEENQQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0401	QYRVVQEENQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0401	EQYRVVQEENQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0407	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0409	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0413	QYRVVQEENQQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0413	EQYRVVQEENQQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0413	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0413	YRVVQEENQQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0413	QYRVVQEENQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0413	EQYRVVQEENQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0413	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0413	YRVVQEENQQGIQQT	5	20
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0422	QYRVVQEENQQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0422	EQYRVVQEENQQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0422	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0422	YRVVQEENQQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0422	QYRVVQEENQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0422	EQYRVVQEENQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0422	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0422	YRVVQEENQQGIQQT	5	20
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0424	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0424	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0424	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0424	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0431	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0433	QYRVVQEENQQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0433	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0433	EQYRVVQEENQQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0433	QYRVVQEENQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0433	EQYRVVQEENQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0434	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0434	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0435	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0435	QYRVVQEENQQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0435	EQYRVVQEENQQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0435	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0435	QYRVVQEENQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0435	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0435	EQYRVVQEENQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0437	QYRVVQEENQQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0437	QYRVVQEENQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0438	QYRVVQEENQQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0438	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0438	QYRVVQEENQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0438	EQYRVVQEENQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0440	QYRVVQEENQQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0440	EQYRVVQEENQQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0440	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0440	QYRVVQEENQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0440	EQYRVVQEENQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0442	QYRVVQEENQQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0442	EQYRVVQEENQQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0442	QYRVVQEENQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0442	EQYRVVQEENQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0443	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0443	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0443	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0444	QYRVVQEENQQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0444	EQYRVVQEENQQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0444	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0444	QYRVVQEENQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0444	EQYRVVQEENQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0444	YRVVQEENQQGIQQT	5	20
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0444	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0447	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0447	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0447	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0447	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0454	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0454	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0454	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0454	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0455	QYRVVQEENQQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0455	QYRVVQEENQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0455	EQYRVVQEENQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0456	QYRVVQEENQQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0456	EQYRVVQEENQQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0456	QYRVVQEENQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0456	EQYRVVQEENQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0459	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0462	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0463	QYRVVQEENQQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0463	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0463	EQYRVVQEENQQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0463	QYRVVQEENQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0463	EQYRVVQEENQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0464	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0464	QYRVVQEENQQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0464	QYRVVQEENQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0464	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0464	EQYRVVQEENQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0466	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0467	QYRVVQEENQQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0468	QYRVVQEENQQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0468	EQYRVVQEENQQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0468	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0468	QYRVVQEENQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0468	EQYRVVQEENQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0469	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0469	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0469	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0469	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0470	QYRVVQEENQQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0470	EQYRVVQEENQQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0470	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0470	QYRVVQEENQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0470	EQYRVVQEENQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0472	QYRVVQEENQQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0472	QYRVVQEENQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0472	EQYRVVQEENQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0473	QYRVVQEENQQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0473	QYRVVQEENQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0475	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0476	QYRVVQEENQQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0476	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0476	EQYRVVQEENQQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0476	QYRVVQEENQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0476	EQYRVVQEENQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0479	QYRVVQEENQQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0479	EQYRVVQEENQQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0479	QYRVVQEENQQGIQQ	4	19
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0479	EQYRVVQEENQQGIQ	3	18
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0480	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0480	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0480	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0480	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0482	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0486	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0486	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0486	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0487	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0801	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0801	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0801	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0801	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0802	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0803	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0803	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0803	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0803	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0805	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0805	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0805	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0805	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0807	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0807	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0807	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0807	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0808	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0808	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0808	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0808	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0809	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0811	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0811	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0811	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0811	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0813	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0814	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0814	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0814	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0814	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0815	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0816	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0816	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0816	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0816	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0818	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0818	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0818	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0818	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0821	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0823	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0823	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0823	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0823	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0824	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0825	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0826	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0826	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0826	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0826	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0827	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0827	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0827	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0827	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0829	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0830	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0832	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0832	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0832	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0832	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0833	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0833	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0833	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0833	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0835	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0835	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0835	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0835	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0836	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0836	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0836	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0836	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0837	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0837	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0837	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0837	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0838	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0838	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0838	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0838	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0839	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0839	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0839	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0839	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0840	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0902	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0902	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0902	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0902	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0903	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0903	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0903	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0903	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0905	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0908	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0908	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0908	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0908	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-0908	IWKEQYRVVQEENQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1105	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1130	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1130	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1130	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1130	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1216	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-13100	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-13100	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-13100	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1313	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1346	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1346	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1346	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1349	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1360	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1422	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1422	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1422	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1422	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1425	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1425	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1425	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1425	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1446	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1446	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1446	KEQYRVVQEENQQGI	2	17
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1446	WKEQYRVVQEENQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1453	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1469	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1469	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1485	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1604	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1609	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1612	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB1-1614	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB5-0112	KEQYRVVQEENQQQG	1	16
ERC1-WNK1	chr12	1137738	chr12	987378	801	DRB5-0112	WKEQYRVVQEENQQQ	0	15
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-0437	LQTVIEMKAQGQSQG	5	20
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-0802	QTVIEMKAQGQSQGQ	6	21
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-0802	LQTVIEMKAQGQSQG	5	20
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-0804	QTVIEMKAQGQSQGQ	6	21
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-0804	LQTVIEMKAQGQSQG	5	20
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-0804	TVIEMKAQGQSQGQP	7	22
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-0804	ALQTVIEMKAQGQSQ	4	19
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-0806	QTVIEMKAQGQSQGQ	6	21
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-0809	QTVIEMKAQGQSQGQ	6	21
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-0809	LQTVIEMKAQGQSQG	5	20
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-0820	QTVIEMKAQGQSQGQ	6	21
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-0820	LQTVIEMKAQGQSQG	5	20
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-0821	QTVIEMKAQGQSQGQ	6	21
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-0821	LQTVIEMKAQGQSQG	5	20
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-0828	QTVIEMKAQGQSQGQ	6	21
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-0828	LQTVIEMKAQGQSQG	5	20
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-0828	TVIEMKAQGQSQGQP	7	22
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-0828	ALQTVIEMKAQGQSQ	4	19
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-0831	QTVIEMKAQGQSQGQ	6	21
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-0831	LQTVIEMKAQGQSQG	5	20
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-1125	QTVIEMKAQGQSQGQ	6	21
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-1125	LQTVIEMKAQGQSQG	5	20
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-1167	QTVIEMKAQGQSQGQ	6	21
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-1167	LQTVIEMKAQGQSQG	5	20
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-1167	TVIEMKAQGQSQGQP	7	22
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-1167	ALQTVIEMKAQGQSQ	4	19
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-1204	LQTVIEMKAQGQSQG	5	20
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-1209	LQTVIEMKAQGQSQG	5	20
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-1318	QTVIEMKAQGQSQGQ	6	21
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-1318	LQTVIEMKAQGQSQG	5	20
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-1412	QTVIEMKAQGQSQGQ	6	21
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-1412	LQTVIEMKAQGQSQG	5	20
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-1415	QTVIEMKAQGQSQGQ	6	21
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-1415	LQTVIEMKAQGQSQG	5	20
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-1415	TVIEMKAQGQSQGQP	7	22
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-1415	ALQTVIEMKAQGQSQ	4	19
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-1484	QTVIEMKAQGQSQGQ	6	21
ERC1-WNK1	chr12	1213990	chr12	980431	1293	DRB1-1484	LQTVIEMKAQGQSQG	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0437	QTVIEMKQGIQQTAP	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0802	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0804	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0804	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0804	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0804	QTVIEMKQGIQQTAP	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0804	LQTVIEMKQGIQQTA	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0806	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0806	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0809	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0810	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0820	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0821	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0822	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0822	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0828	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0828	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0828	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0828	TVIEMKQQGIQQTAP	7	22
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0828	QTVIEMKQGIQQTAP	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0828	LQTVIEMKQGIQQTA	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-0831	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1125	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1125	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1167	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1167	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1167	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1167	TVIEMKQQGIQQTAP	7	22
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1167	QTVIEMKQGIQQTAP	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1167	LQTVIEMKQGIQQTA	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1201	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1201	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1203	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1203	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1205	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1205	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1206	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1206	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1207	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1207	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1208	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1208	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1210	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1210	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1211	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1211	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1212	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1212	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1213	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1213	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1213	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1214	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1214	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1215	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1215	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1215	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1217	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1217	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1218	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1218	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1218	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1219	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1219	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1219	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1220	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1220	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1220	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1221	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1221	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1221	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1223	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1223	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1223	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1318	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1318	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1412	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1412	QTVIEMKQGIQQTAP	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1415	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1415	LQTVIEMKQQGIQQT	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1415	ALQTVIEMKQQGIQQ	4	19
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1415	QTVIEMKQGIQQTAP	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1415	LQTVIEMKQGIQQTA	5	20
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1484	QTVIEMKQQGIQQTA	6	21
ERC1-WNK1	chr12	1213990	chr12	987377	1293	DRB1-1484	QTVIEMKQGIQQTAP	6	21

Top

Fusion breakpoint peptide structures of ERC1-WNK1

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
7607	QTVIEMKQGIQQTA	ERC1	WNK1	chr12	1213990	chr12	987377	1293

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
7608	QTVIEMKQQGIQQT	ERC1	WNK1	chr12	1213990	chr12	987377	1293

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
8335	RVVQEENQQGIQQT	ERC1	WNK1	chr12	1137738	chr12	987378	801

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
10367	VVQEENQQQGIQQT	ERC1	WNK1	chr12	1137738	chr12	987378	801

Top

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ERC1-WNK1

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	7607	QTVIEMKQGIQQTA	-7.9962	-8.1096
HLA-B14:02	3BVN	7607	QTVIEMKQGIQQTA	-5.70842	-6.74372
HLA-B52:01	3W39	7607	QTVIEMKQGIQQTA	-6.83737	-6.95077
HLA-B52:01	3W39	7607	QTVIEMKQGIQQTA	-4.4836	-5.5189
HLA-A11:01	4UQ2	7607	QTVIEMKQGIQQTA	-10.0067	-10.1201
HLA-A11:01	4UQ2	7607	QTVIEMKQGIQQTA	-9.03915	-10.0745
HLA-A24:02	5HGA	7607	QTVIEMKQGIQQTA	-6.56204	-6.67544
HLA-A24:02	5HGA	7607	QTVIEMKQGIQQTA	-5.42271	-6.45801
HLA-B44:05	3DX8	7607	QTVIEMKQGIQQTA	-7.85648	-8.89178
HLA-B44:05	3DX8	7607	QTVIEMKQGIQQTA	-5.3978	-5.5112
HLA-A02:01	6TDR	7607	QTVIEMKQGIQQTA	-3.37154	-4.40684
HLA-B14:02	3BVN	7608	QTVIEMKQQGIQQT	-7.9962	-8.1096
HLA-B14:02	3BVN	7608	QTVIEMKQQGIQQT	-5.70842	-6.74372
HLA-B52:01	3W39	7608	QTVIEMKQQGIQQT	-6.83737	-6.95077
HLA-B52:01	3W39	7608	QTVIEMKQQGIQQT	-4.4836	-5.5189
HLA-A11:01	4UQ2	7608	QTVIEMKQQGIQQT	-10.0067	-10.1201
HLA-A11:01	4UQ2	7608	QTVIEMKQQGIQQT	-9.03915	-10.0745
HLA-A24:02	5HGA	7608	QTVIEMKQQGIQQT	-6.56204	-6.67544
HLA-A24:02	5HGA	7608	QTVIEMKQQGIQQT	-5.42271	-6.45801
HLA-B44:05	3DX8	7608	QTVIEMKQQGIQQT	-7.85648	-8.89178
HLA-B44:05	3DX8	7608	QTVIEMKQQGIQQT	-5.3978	-5.5112
HLA-A02:01	6TDR	7608	QTVIEMKQQGIQQT	-3.37154	-4.40684
HLA-B14:02	3BVN	8335	RVVQEENQQGIQQT	-7.15543	-7.26883
HLA-B14:02	3BVN	8335	RVVQEENQQGIQQT	-4.77435	-5.80965
HLA-B52:01	3W39	8335	RVVQEENQQGIQQT	-6.80875	-6.92215
HLA-B52:01	3W39	8335	RVVQEENQQGIQQT	-4.20386	-5.23916
HLA-A11:01	4UQ2	8335	RVVQEENQQGIQQT	-7.5194	-8.5547
HLA-A11:01	4UQ2	8335	RVVQEENQQGIQQT	-6.9601	-7.0735
HLA-A24:02	5HGA	8335	RVVQEENQQGIQQT	-7.52403	-7.63743
HLA-A24:02	5HGA	8335	RVVQEENQQGIQQT	-5.82433	-6.85963
HLA-B27:05	6PYJ	8335	RVVQEENQQGIQQT	-3.28285	-4.31815
HLA-B44:05	3DX8	8335	RVVQEENQQGIQQT	-5.91172	-6.94702
HLA-B44:05	3DX8	8335	RVVQEENQQGIQQT	-4.24346	-4.35686
HLA-B14:02	3BVN	10367	VVQEENQQQGIQQT	-7.15543	-7.26883
HLA-B14:02	3BVN	10367	VVQEENQQQGIQQT	-4.77435	-5.80965
HLA-B52:01	3W39	10367	VVQEENQQQGIQQT	-6.80875	-6.92215
HLA-B52:01	3W39	10367	VVQEENQQQGIQQT	-4.20386	-5.23916
HLA-A11:01	4UQ2	10367	VVQEENQQQGIQQT	-7.5194	-8.5547
HLA-A11:01	4UQ2	10367	VVQEENQQQGIQQT	-6.9601	-7.0735
HLA-A24:02	5HGA	10367	VVQEENQQQGIQQT	-7.52403	-7.63743
HLA-A24:02	5HGA	10367	VVQEENQQQGIQQT	-5.82433	-6.85963
HLA-B27:05	6PYJ	10367	VVQEENQQQGIQQT	-3.28285	-4.31815
HLA-B44:05	3DX8	10367	VVQEENQQQGIQQT	-5.91172	-6.94702
HLA-B44:05	3DX8	10367	VVQEENQQQGIQQT	-4.24346	-4.35686
HLA-B35:01	1A1N	10367	VVQEENQQQGIQQT	-5.9251	-6.0385
HLA-B35:01	1A1N	10367	VVQEENQQQGIQQT	-4.80237	-5.83767

Top

Vaccine Design for the FusionNeoAntigens of ERC1-WNK1

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
ERC1-WNK1	chr12	1137738	chr12	987378	10	20	EENQQGIQQT	GAAAACCAGCAGGGAATACAGCAGACAGCC
ERC1-WNK1	chr12	1137738	chr12	987378	10	21	EENQQGIQQTA	GAAAACCAGCAGGGAATACAGCAGACAGCCCCT
ERC1-WNK1	chr12	1137738	chr12	987378	12	21	NQQGIQQTA	CAGCAGGGAATACAGCAGACAGCCCCT
ERC1-WNK1	chr12	1137738	chr12	987378	12	21	QQQGIQQTA	CAGCAGCAGGGAATACAGCAGACAGCC
ERC1-WNK1	chr12	1137738	chr12	987378	8	17	QEENQQQGI	CAGGAGGAAAACCAGCAGCAGGGAATA
ERC1-WNK1	chr12	1137738	chr12	987378	8	17	VQEENQQGI	CAGGAGGAAAACCAGCAGGGAATACAG
ERC1-WNK1	chr12	1213990	chr12	987377	10	19	EMKQGIQQT	GAGATGAAGCAGGGAATACAGCAGACA
ERC1-WNK1	chr12	1213990	chr12	987377	11	20	MKQGIQQTA	ATGAAGCAGGGAATACAGCAGACAGCC
ERC1-WNK1	chr12	1213990	chr12	987377	12	21	KQQGIQQTA	AAGCAGCAGGGAATACAGCAGACAGCC
ERC1-WNK1	chr12	1213990	chr12	987377	7	16	TVIEMKQGI	ACTGTTATTGAGATGAAGCAGGGAATA
ERC1-WNK1	chr12	1213990	chr12	987377	9	20	IEMKQGIQQTA	ATTGAGATGAAGCAGGGAATACAGCAGACAGCC

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
ERC1-WNK1	chr12	1137738	chr12	987378	0	15	IWKEQYRVVQEENQQ	TGGAAGGAACAGTACAGAGTTGTACAGGAGGAAAACCAGCAGGGA
ERC1-WNK1	chr12	1137738	chr12	987378	0	15	WKEQYRVVQEENQQQ	TGGAAGGAACAGTACAGAGTTGTACAGGAGGAAAACCAGCAGCAG
ERC1-WNK1	chr12	1137738	chr12	987378	1	16	KEQYRVVQEENQQQG	AAGGAACAGTACAGAGTTGTACAGGAGGAAAACCAGCAGCAGGGA
ERC1-WNK1	chr12	1137738	chr12	987378	1	16	WKEQYRVVQEENQQG	AAGGAACAGTACAGAGTTGTACAGGAGGAAAACCAGCAGGGAATA
ERC1-WNK1	chr12	1137738	chr12	987378	2	17	EQYRVVQEENQQQGI	GAACAGTACAGAGTTGTACAGGAGGAAAACCAGCAGCAGGGAATA
ERC1-WNK1	chr12	1137738	chr12	987378	2	17	KEQYRVVQEENQQGI	GAACAGTACAGAGTTGTACAGGAGGAAAACCAGCAGGGAATACAG
ERC1-WNK1	chr12	1137738	chr12	987378	3	18	EQYRVVQEENQQGIQ	CAGTACAGAGTTGTACAGGAGGAAAACCAGCAGGGAATACAGCAG
ERC1-WNK1	chr12	1137738	chr12	987378	3	18	QYRVVQEENQQQGIQ	CAGTACAGAGTTGTACAGGAGGAAAACCAGCAGCAGGGAATACAG
ERC1-WNK1	chr12	1137738	chr12	987378	4	19	QYRVVQEENQQGIQQ	TACAGAGTTGTACAGGAGGAAAACCAGCAGGGAATACAGCAGACA
ERC1-WNK1	chr12	1137738	chr12	987378	4	19	YRVVQEENQQQGIQQ	TACAGAGTTGTACAGGAGGAAAACCAGCAGCAGGGAATACAGCAG
ERC1-WNK1	chr12	1137738	chr12	987378	5	20	YRVVQEENQQGIQQT	AGAGTTGTACAGGAGGAAAACCAGCAGGGAATACAGCAGACAGCC
ERC1-WNK1	chr12	1213990	chr12	980431	4	19	ALQTVIEMKAQGQSQ	GCTCTGCAAACTGTTATTGAGATGAAGGCACAGGGGCAGAGCCAG
ERC1-WNK1	chr12	1213990	chr12	980431	5	20	LQTVIEMKAQGQSQG	CTGCAAACTGTTATTGAGATGAAGGCACAGGGGCAGAGCCAGGGT
ERC1-WNK1	chr12	1213990	chr12	980431	6	21	QTVIEMKAQGQSQGQ	CAAACTGTTATTGAGATGAAGGCACAGGGGCAGAGCCAGGGTCAG
ERC1-WNK1	chr12	1213990	chr12	980431	7	22	TVIEMKAQGQSQGQP	ACTGTTATTGAGATGAAGGCACAGGGGCAGAGCCAGGGTCAGCCA
ERC1-WNK1	chr12	1213990	chr12	987377	4	19	ALQTVIEMKQQGIQQ	GCTCTGCAAACTGTTATTGAGATGAAGCAGCAGGGAATACAGCAG
ERC1-WNK1	chr12	1213990	chr12	987377	5	20	LQTVIEMKQGIQQTA	CTGCAAACTGTTATTGAGATGAAGCAGGGAATACAGCAGACAGCC
ERC1-WNK1	chr12	1213990	chr12	987377	5	20	LQTVIEMKQQGIQQT	CTGCAAACTGTTATTGAGATGAAGCAGCAGGGAATACAGCAGACA
ERC1-WNK1	chr12	1213990	chr12	987377	6	21	QTVIEMKQGIQQTAP	CAAACTGTTATTGAGATGAAGCAGGGAATACAGCAGACAGCCCCT
ERC1-WNK1	chr12	1213990	chr12	987377	6	21	QTVIEMKQQGIQQTA	CAAACTGTTATTGAGATGAAGCAGCAGGGAATACAGCAGACAGCC
ERC1-WNK1	chr12	1213990	chr12	987377	7	22	TVIEMKQQGIQQTAP	ACTGTTATTGAGATGAAGCAGCAGGGAATACAGCAGACAGCCCCT

Top

Information of the samples that have these potential fusion neoantigens of ERC1-WNK1

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
ESCA	ERC1-WNK1	chr12	1213990	ENST00000355446	chr12	987377	ENST00000315939	TCGA-L5-A8NI
LUAD	ERC1-WNK1	chr12	1137738	ENST00000355446	chr12	987378	ENST00000315939	TCGA-78-8660-01A
ESCA	ERC1-WNK1	chr12	1213990	ENST00000355446	chr12	987377	ENST00000535572	TCGA-L5-A8NI
LUAD	ERC1-WNK1	chr12	1137738	ENST00000355446	chr12	987378	ENST00000535572	TCGA-78-8660-01A

Top

Potential target of CAR-T therapy development for ERC1-WNK1

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

Top

Related Drugs to ERC1-WNK1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ERC1-WNK1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ERC1	C0238463	Papillary thyroid carcinoma	1	ORPHANET
Hgene	ERC1	C4749581	Distal monosomy 12p	1	ORPHANET

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)