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Fusion Protein:FAM120A-WNK2

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: FAM120A-WNK2
	FusionPDB ID: 28408
	FusionGDB2.0 ID: 28408
		Hgene	Tgene
	Gene symbol	FAM120A	WNK2
	Gene ID	23196	65268
	Gene name	family with sequence similarity 120A	WNK lysine deficient protein kinase 2
	Synonyms	C9orf10\|HBVPTPAP\|OSSA	NY-CO-43\|P/OKcl.13\|PRKWNK2\|SDCCAG43
	Cytomap	9q22.31	9q22.31
	Type of gene	protein-coding	protein-coding
	Description	constitutive coactivator of PPAR-gamma-like protein 1oxidative stess-associated Src activatoroxidative stress-associated Src activator	serine/threonine-protein kinase WNK2antigen NY-CO-43mitogen-activated protein kinase kinase kinaseprotein kinase lysine-deficient 2protein kinase with no lysine 2serologically defined colon cancer antigen 43
	Modification date	20200320	20200313
	UniProtAcc	Q5T036 Main function of 5'-partner protein:	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000277165, ENST00000333936, ENST00000340893, ENST00000375389, ENST00000475933,	ENST00000395475, ENST00000349097, ENST00000356055, ENST00000395477, ENST00000471076, ENST00000297954, ENST00000427277,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 9 X 4=360	10 X 9 X 7=630
	# samples	12	12
	** MAII score	log2(12/360*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/630*10)=-2.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: FAM120A [Title/Abstract] AND WNK2 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: FAM120A [Title/Abstract] AND WNK2 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	FAM120A(96261168)-WNK2(96030909), # samples:3 WNK2(96021896)-FAM120A(96259753), # samples:1 WNK2(96021896)-FAM120A(96259752), # samples:1
Anticipated loss of major functional domain due to fusion event.	FAM120A-WNK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FAM120A-WNK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	WNK2	GO:0006468	protein phosphorylation	21733846
Tgene	WNK2	GO:0046777	protein autophosphorylation	17667937

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:96261168/chr9:96030909)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across FAM120A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across WNK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000277165	FAM120A	chr9	96261168	+	ENST00000427277	WNK2	chr9	96030909	+	3986	1224	194	3985	1264
ENST00000277165	FAM120A	chr9	96261168	+	ENST00000297954	WNK2	chr9	96030909	+	4449	1224	194	4204	1336
ENST00000375389	FAM120A	chr9	96261168	+	ENST00000427277	WNK2	chr9	96030909	+	3817	1055	25	3816	1264
ENST00000375389	FAM120A	chr9	96261168	+	ENST00000297954	WNK2	chr9	96030909	+	4280	1055	25	4035	1336
ENST00000340893	FAM120A	chr9	96261168	+	ENST00000427277	WNK2	chr9	96030909	+	3817	1055	25	3816	1264
ENST00000340893	FAM120A	chr9	96261168	+	ENST00000297954	WNK2	chr9	96030909	+	4280	1055	25	4035	1336
ENST00000333936	FAM120A	chr9	96261168	+	ENST00000427277	WNK2	chr9	96030909	+	3817	1055	25	3816	1264
ENST00000333936	FAM120A	chr9	96261168	+	ENST00000297954	WNK2	chr9	96030909	+	4280	1055	25	4035	1336
ENST00000277165	FAM120A	chr9	96261168	+	ENST00000427277	WNK2	chr9	96030908	+	3986	1224	194	3985	1264
ENST00000277165	FAM120A	chr9	96261168	+	ENST00000297954	WNK2	chr9	96030908	+	4449	1224	194	4204	1336
ENST00000375389	FAM120A	chr9	96261168	+	ENST00000427277	WNK2	chr9	96030908	+	3817	1055	25	3816	1264
ENST00000375389	FAM120A	chr9	96261168	+	ENST00000297954	WNK2	chr9	96030908	+	4280	1055	25	4035	1336
ENST00000340893	FAM120A	chr9	96261168	+	ENST00000427277	WNK2	chr9	96030908	+	3817	1055	25	3816	1264
ENST00000340893	FAM120A	chr9	96261168	+	ENST00000297954	WNK2	chr9	96030908	+	4280	1055	25	4035	1336
ENST00000333936	FAM120A	chr9	96261168	+	ENST00000427277	WNK2	chr9	96030908	+	3817	1055	25	3816	1264
ENST00000333936	FAM120A	chr9	96261168	+	ENST00000297954	WNK2	chr9	96030908	+	4280	1055	25	4035	1336

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000277165	ENST00000427277	FAM120A	chr9	96261168	+	WNK2	chr9	96030909	+	0.013826363	0.9861736
ENST00000277165	ENST00000297954	FAM120A	chr9	96261168	+	WNK2	chr9	96030909	+	0.012265521	0.9877345
ENST00000375389	ENST00000427277	FAM120A	chr9	96261168	+	WNK2	chr9	96030909	+	0.012145756	0.9878542
ENST00000375389	ENST00000297954	FAM120A	chr9	96261168	+	WNK2	chr9	96030909	+	0.010844493	0.9891555
ENST00000340893	ENST00000427277	FAM120A	chr9	96261168	+	WNK2	chr9	96030909	+	0.012145756	0.9878542
ENST00000340893	ENST00000297954	FAM120A	chr9	96261168	+	WNK2	chr9	96030909	+	0.010844493	0.9891555
ENST00000333936	ENST00000427277	FAM120A	chr9	96261168	+	WNK2	chr9	96030909	+	0.012145756	0.9878542
ENST00000333936	ENST00000297954	FAM120A	chr9	96261168	+	WNK2	chr9	96030909	+	0.010844493	0.9891555
ENST00000277165	ENST00000427277	FAM120A	chr9	96261168	+	WNK2	chr9	96030908	+	0.013826363	0.9861736
ENST00000277165	ENST00000297954	FAM120A	chr9	96261168	+	WNK2	chr9	96030908	+	0.012265521	0.9877345
ENST00000375389	ENST00000427277	FAM120A	chr9	96261168	+	WNK2	chr9	96030908	+	0.012145756	0.9878542
ENST00000375389	ENST00000297954	FAM120A	chr9	96261168	+	WNK2	chr9	96030908	+	0.010844493	0.9891555
ENST00000340893	ENST00000427277	FAM120A	chr9	96261168	+	WNK2	chr9	96030908	+	0.012145756	0.9878542
ENST00000340893	ENST00000297954	FAM120A	chr9	96261168	+	WNK2	chr9	96030908	+	0.010844493	0.9891555
ENST00000333936	ENST00000427277	FAM120A	chr9	96261168	+	WNK2	chr9	96030908	+	0.012145756	0.9878542
ENST00000333936	ENST00000297954	FAM120A	chr9	96261168	+	WNK2	chr9	96030908	+	0.010844493	0.9891555

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for FAM120A-WNK2

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
FAM120A	chr9	96261168	WNK2	chr9	96030908	1055	343	TSKPMSFHPPHYLVLHTGKRWFIICP
FAM120A	chr9	96261168	WNK2	chr9	96030908	1224	343	TSKPMSFHPPHYLVLHTGKRWFIICP
FAM120A	chr9	96261168	WNK2	chr9	96030909	1055	343	TSKPMSFHPPHYLVLHTGKRWFIICP
FAM120A	chr9	96261168	WNK2	chr9	96030909	1224	343	TSKPMSFHPPHYLVLHTGKRWFIICP

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Potential FusionNeoAntigen Information of FAM120A-WNK2 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

FAM120A-WNK2_96261168_96030908.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B39:06	FHPPHYLV	0.9993	0.8038	6	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B39:24	FHPPHYLV	0.999	0.5623	6	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B35:03	HPPHYLVL	0.978	0.8074	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B08:01	HPPHYLVL	0.9767	0.6481	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B08:09	HPPHYLVL	0.966	0.6465	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B15:37	FHPPHYLV	0.9592	0.7579	6	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B35:02	HPPHYLVL	0.9241	0.8085	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B35:04	HPPHYLVL	0.9241	0.8085	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B57:01	LVLHTGKRW	0.9962	0.9867	12	21
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B39:06	FHPPHYLVL	0.993	0.7477	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B39:01	FHPPHYLVL	0.9922	0.9204	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B58:01	LVLHTGKRW	0.9912	0.9694	12	21
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B58:02	LVLHTGKRW	0.9909	0.932	12	21
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B15:17	LVLHTGKRW	0.9793	0.9372	12	21
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B15:10	FHPPHYLVL	0.9792	0.5252	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B14:02	FHPPHYLVL	0.9785	0.7072	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B14:01	FHPPHYLVL	0.9785	0.7072	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B39:13	FHPPHYLVL	0.9761	0.9007	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B38:01	FHPPHYLVL	0.9733	0.9046	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B38:02	FHPPHYLVL	0.9721	0.9314	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B57:03	LVLHTGKRW	0.9532	0.9907	12	21
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B15:37	FHPPHYLVL	0.9339	0.5188	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-A31:08	SFHPPHYLV	0.9141	0.5313	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B15:18	FHPPHYLVL	0.8319	0.6474	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-A24:14	SFHPPHYLV	0.7937	0.6176	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-A32:13	LVLHTGKRW	0.7652	0.9758	12	21
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B08:09	FHPPHYLVL	0.3986	0.5811	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B15:16	MSFHPPHYLV	0.9813	0.808	4	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B14:02	SFHPPHYLVL	0.8848	0.8177	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B14:01	SFHPPHYLVL	0.8848	0.8177	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-A24:14	SFHPPHYLVL	0.8214	0.5003	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B15:10	SFHPPHYLVL	0.6533	0.5417	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B15:37	SFHPPHYLVL	0.589	0.6422	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B39:01	SFHPPHYLVL	0.5568	0.9313	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B38:01	SFHPPHYLVL	0.4239	0.9592	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B15:17	MSFHPPHYLVL	0.999	0.887	4	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B57:03	MSFHPPHYLVL	0.999	0.9691	4	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B15:16	MSFHPPHYLVL	0.9984	0.6944	4	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B39:09	FHPPHYLV	0.9988	0.8496	6	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B39:05	FHPPHYLV	0.9947	0.9551	6	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B14:03	HPPHYLVL	0.99	0.7279	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B42:02	HPPHYLVL	0.9863	0.6479	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B42:01	HPPHYLVL	0.9795	0.6432	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:29	FHPPHYLV	0.9665	0.9675	6	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C01:17	HPPHYLVL	0.9505	0.9345	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:13	FHPPHYLV	0.9356	0.9526	6	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C01:30	HPPHYLVL	0.9301	0.9522	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B35:12	HPPHYLVL	0.9241	0.8085	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B14:03	FHPPHYLV	0.9028	0.9295	6	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:29	HPPHYLVL	0.8884	0.876	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B39:09	HPPHYLVL	0.8726	0.5892	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:13	HPPHYLVL	0.8701	0.8287	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B39:10	HPPHYLVL	0.8594	0.8961	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B39:09	FHPPHYLVL	0.9971	0.7031	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B39:12	FHPPHYLVL	0.988	0.9271	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B39:05	FHPPHYLVL	0.9785	0.9037	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C08:03	FHPPHYLVL	0.7364	0.9344	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:05	FHPPHYLVL	0.702	0.9565	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:27	FHPPHYLVL	0.6906	0.9399	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:80	FHPPHYLVL	0.6781	0.9124	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:67	FHPPHYLVL	0.6781	0.9124	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:46	FHPPHYLVL	0.6655	0.8187	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:13	FHPPHYLVL	0.6643	0.8901	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:95	FHPPHYLVL	0.6544	0.6963	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:10	FHPPHYLVL	0.6191	0.9427	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:19	FHPPHYLVL	0.6174	0.711	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:29	FHPPHYLVL	0.6031	0.94	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C04:06	FHPPHYLVL	0.5671	0.8488	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C04:14	SFHPPHYLV	0.5648	0.8872	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B14:03	FHPPHYLVL	0.5395	0.8353	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:05	SFHPPHYLV	0.495	0.9801	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C01:30	FHPPHYLVL	0.4511	0.9639	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C04:14	FHPPHYLVL	0.4114	0.7344	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:19	SFHPPHYLV	0.3997	0.8643	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:80	SFHPPHYLV	0.3355	0.9733	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:67	SFHPPHYLV	0.3355	0.9733	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:29	SFHPPHYLV	0.3351	0.9751	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:10	SFHPPHYLV	0.3199	0.9783	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:46	SFHPPHYLV	0.3083	0.9438	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C01:17	FHPPHYLVL	0.3012	0.9428	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C12:16	FHPPHYLVL	0.2981	0.9666	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:13	SFHPPHYLV	0.2961	0.9778	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:27	SFHPPHYLV	0.2001	0.9794	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:95	SFHPPHYLV	0.1932	0.8656	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C12:16	SFHPPHYLV	0.1622	0.9715	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C04:10	SFHPPHYLV	0.143	0.8462	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C04:07	SFHPPHYLV	0.1417	0.8982	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C04:10	FHPPHYLVL	0.0754	0.748	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C04:07	FHPPHYLVL	0.0723	0.7657	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:29	SFHPPHYLVL	0.872	0.9644	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:10	SFHPPHYLVL	0.8572	0.9539	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:13	SFHPPHYLVL	0.8516	0.941	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:19	SFHPPHYLVL	0.8463	0.7254	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:67	SFHPPHYLVL	0.8419	0.939	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:80	SFHPPHYLVL	0.8419	0.939	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:46	SFHPPHYLVL	0.8348	0.865	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C01:17	SFHPPHYLVL	0.8269	0.9441	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B14:03	SFHPPHYLVL	0.8198	0.903	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C01:30	SFHPPHYLVL	0.8078	0.9707	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:13	FHPPHYLVLH	0.7022	0.8146	6	16
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B39:09	SFHPPHYLVL	0.647	0.7337	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B39:12	SFHPPHYLVL	0.5829	0.9381	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B39:05	SFHPPHYLVL	0.4085	0.9173	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C03:08	MSFHPPHYLVL	0.9997	0.904	4	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C15:06	MSFHPPHYLVL	0.9997	0.9392	4	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:13	MSFHPPHYLVL	0.9789	0.9026	4	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C01:17	MSFHPPHYLVL	0.9739	0.9397	4	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C01:30	MSFHPPHYLVL	0.934	0.9691	4	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B39:09	MSFHPPHYLVL	0.8786	0.7327	4	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B08:18	HPPHYLVL	0.9767	0.6481	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B08:12	HPPHYLVL	0.9531	0.803	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:04	FHPPHYLV	0.951	0.9166	6	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B15:09	FHPPHYLV	0.95	0.5909	6	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B67:01	HPPHYLVL	0.9356	0.6631	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B35:30	HPPHYLVL	0.9328	0.5054	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B35:17	HPPHYLVL	0.9328	0.5054	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C01:02	HPPHYLVL	0.9313	0.9345	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B35:09	HPPHYLVL	0.9241	0.8085	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C01:03	HPPHYLVL	0.7906	0.9102	7	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B57:10	LVLHTGKRW	0.9962	0.9867	12	21
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B39:31	FHPPHYLVL	0.9936	0.918	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B39:02	FHPPHYLVL	0.9913	0.9093	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B57:04	LVLHTGKRW	0.9911	0.6818	12	21
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B58:06	LVLHTGKRW	0.9908	0.8991	12	21
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B38:05	FHPPHYLVL	0.9733	0.9046	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B57:02	LVLHTGKRW	0.9145	0.8872	12	21
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-A32:01	LVLHTGKRW	0.8485	0.9569	12	21
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B15:13	LVLHTGKRW	0.8432	0.7851	12	21
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C03:67	FHPPHYLVL	0.7623	0.9756	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C08:01	FHPPHYLVL	0.7364	0.9344	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:22	FHPPHYLVL	0.7191	0.773	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B39:11	FHPPHYLVL	0.6882	0.8446	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:02	FHPPHYLVL	0.6781	0.9124	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:01	FHPPHYLVL	0.6476	0.6574	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:17	FHPPHYLVL	0.6466	0.9677	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:04	FHPPHYLVL	0.5984	0.8721	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C04:04	SFHPPHYLV	0.58	0.9526	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B08:12	FHPPHYLVL	0.5298	0.7644	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C06:17	SFHPPHYLV	0.5076	0.9951	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C06:02	SFHPPHYLV	0.5076	0.9951	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C04:04	FHPPHYLVL	0.5035	0.8123	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C06:08	SFHPPHYLV	0.4763	0.9917	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B15:24	LVLHTGKRW	0.4285	0.9436	12	21
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:02	SFHPPHYLV	0.3355	0.9733	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C03:67	SFHPPHYLV	0.3165	0.9905	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C01:02	FHPPHYLVL	0.3029	0.941	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:04	SFHPPHYLV	0.2819	0.9455	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:17	SFHPPHYLV	0.2778	0.9804	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C06:06	SFHPPHYLV	0.2686	0.9927	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C06:06	FHPPHYLVL	0.2684	0.9827	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C06:17	FHPPHYLVL	0.261	0.9942	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C06:02	FHPPHYLVL	0.261	0.9942	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C14:02	FHPPHYLVL	0.2512	0.9615	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C14:03	FHPPHYLVL	0.2512	0.9615	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:22	SFHPPHYLV	0.244	0.8712	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:01	SFHPPHYLV	0.2186	0.8709	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C06:08	FHPPHYLVL	0.1775	0.9851	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C01:03	FHPPHYLVL	0.1427	0.9276	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C04:01	SFHPPHYLV	0.1417	0.8982	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C18:01	SFHPPHYLV	0.1221	0.8889	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C18:01	FHPPHYLVL	0.1118	0.7547	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C14:03	SFHPPHYLV	0.1002	0.9713	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C14:02	SFHPPHYLV	0.1002	0.9713	5	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C04:01	FHPPHYLVL	0.0723	0.7657	6	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C15:02	MSFHPPHYLV	0.9995	0.9081	4	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-A68:02	MSFHPPHYLV	0.9953	0.8459	4	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-A69:01	MSFHPPHYLV	0.9917	0.7948	4	14
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C03:67	SFHPPHYLVL	0.937	0.983	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C06:06	SFHPPHYLVL	0.894	0.9874	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:04	SFHPPHYLVL	0.8463	0.9177	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C07:02	SFHPPHYLVL	0.8419	0.939	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C14:03	SFHPPHYLVL	0.8272	0.9635	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C14:02	SFHPPHYLVL	0.8272	0.9635	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C01:03	SFHPPHYLVL	0.8162	0.8844	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C01:02	SFHPPHYLVL	0.8105	0.9426	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B15:09	SFHPPHYLVL	0.4372	0.5558	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-B38:05	SFHPPHYLVL	0.4239	0.9592	5	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C03:05	MSFHPPHYLVL	0.9999	0.9116	4	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C01:03	MSFHPPHYLVL	0.9677	0.862	4	15
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	HLA-C01:02	MSFHPPHYLVL	0.9537	0.9373	4	15

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Potential FusionNeoAntigen Information of FAM120A-WNK2 in HLA II

FAM120A-WNK2_96261168_96030908.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB1-1446	HPPHYLVLHTGKRWF	7	22
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0101	HPPHYLVLHTGKRWF	7	22
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0101	PPHYLVLHTGKRWFI	8	23
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0101	FHPPHYLVLHTGKRW	6	21
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0102	HPPHYLVLHTGKRWF	7	22
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0102	PPHYLVLHTGKRWFI	8	23
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0102	FHPPHYLVLHTGKRW	6	21
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0103	HPPHYLVLHTGKRWF	7	22
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0103	PPHYLVLHTGKRWFI	8	23
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0103	FHPPHYLVLHTGKRW	6	21
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0104	HPPHYLVLHTGKRWF	7	22
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0104	PPHYLVLHTGKRWFI	8	23
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0104	FHPPHYLVLHTGKRW	6	21
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0105	HPPHYLVLHTGKRWF	7	22
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0105	PPHYLVLHTGKRWFI	8	23
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0105	FHPPHYLVLHTGKRW	6	21
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0108N	HPPHYLVLHTGKRWF	7	22
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0108N	PPHYLVLHTGKRWFI	8	23
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0108N	FHPPHYLVLHTGKRW	6	21
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0113	HPPHYLVLHTGKRWF	7	22
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0113	PPHYLVLHTGKRWFI	8	23
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0113	FHPPHYLVLHTGKRW	6	21
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0114	HPPHYLVLHTGKRWF	7	22
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0114	PPHYLVLHTGKRWFI	8	23
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0114	FHPPHYLVLHTGKRW	6	21
FAM120A-WNK2	chr9	96261168	chr9	96030908	1224	DRB5-0203	HPPHYLVLHTGKRWF	7	22

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Fusion breakpoint peptide structures of FAM120A-WNK2

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
2403	FHPPHYLVLHTGKR	FAM120A	WNK2	chr9	96261168	chr9	96030908	1224

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of FAM120A-WNK2

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	2403	FHPPHYLVLHTGKR	-7.9962	-8.1096
HLA-B14:02	3BVN	2403	FHPPHYLVLHTGKR	-5.70842	-6.74372
HLA-B52:01	3W39	2403	FHPPHYLVLHTGKR	-6.83737	-6.95077
HLA-B52:01	3W39	2403	FHPPHYLVLHTGKR	-4.4836	-5.5189
HLA-A11:01	4UQ2	2403	FHPPHYLVLHTGKR	-10.0067	-10.1201
HLA-A11:01	4UQ2	2403	FHPPHYLVLHTGKR	-9.03915	-10.0745
HLA-A24:02	5HGA	2403	FHPPHYLVLHTGKR	-6.56204	-6.67544
HLA-A24:02	5HGA	2403	FHPPHYLVLHTGKR	-5.42271	-6.45801
HLA-B44:05	3DX8	2403	FHPPHYLVLHTGKR	-7.85648	-8.89178
HLA-B44:05	3DX8	2403	FHPPHYLVLHTGKR	-5.3978	-5.5112
HLA-A02:01	6TDR	2403	FHPPHYLVLHTGKR	-3.37154	-4.40684

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Vaccine Design for the FusionNeoAntigens of FAM120A-WNK2

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
FAM120A-WNK2	chr9	96261168	chr9	96030908	12	21	LVLHTGKRW	TAGTCCTGCACACCGGGAAGAGGTGGT
FAM120A-WNK2	chr9	96261168	chr9	96030908	4	14	MSFHPPHYLV	TGTCATTTCATCCACCACATTACTTAGTCC
FAM120A-WNK2	chr9	96261168	chr9	96030908	4	15	MSFHPPHYLVL	TGTCATTTCATCCACCACATTACTTAGTCCTGC
FAM120A-WNK2	chr9	96261168	chr9	96030908	5	14	SFHPPHYLV	CATTTCATCCACCACATTACTTAGTCC
FAM120A-WNK2	chr9	96261168	chr9	96030908	5	15	SFHPPHYLVL	CATTTCATCCACCACATTACTTAGTCCTGC
FAM120A-WNK2	chr9	96261168	chr9	96030908	6	14	FHPPHYLV	TTCATCCACCACATTACTTAGTCC
FAM120A-WNK2	chr9	96261168	chr9	96030908	6	15	FHPPHYLVL	TTCATCCACCACATTACTTAGTCCTGC
FAM120A-WNK2	chr9	96261168	chr9	96030908	6	16	FHPPHYLVLH	TTCATCCACCACATTACTTAGTCCTGCACA
FAM120A-WNK2	chr9	96261168	chr9	96030908	7	15	HPPHYLVL	ATCCACCACATTACTTAGTCCTGC

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
FAM120A-WNK2	chr9	96261168	chr9	96030908	6	21	FHPPHYLVLHTGKRW	TTCATCCACCACATTACTTAGTCCTGCACACCGGGAAGAGGTGGT
FAM120A-WNK2	chr9	96261168	chr9	96030908	7	22	HPPHYLVLHTGKRWF	ATCCACCACATTACTTAGTCCTGCACACCGGGAAGAGGTGGTTCA
FAM120A-WNK2	chr9	96261168	chr9	96030908	8	23	PPHYLVLHTGKRWFI	CACCACATTACTTAGTCCTGCACACCGGGAAGAGGTGGTTCATCA

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Information of the samples that have these potential fusion neoantigens of FAM120A-WNK2

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
STAD	FAM120A-WNK2	chr9	96261168	ENST00000277165	chr9	96030908	ENST00000297954	TCGA-HU-A4GH

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Potential target of CAR-T therapy development for FAM120A-WNK2

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to FAM120A-WNK2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to FAM120A-WNK2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)