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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:AGFG1-SND1

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: AGFG1-SND1
FusionPDB ID: 2873
FusionGDB2.0 ID: 2873
HgeneTgene
Gene symbol

AGFG1

SND1

Gene ID

3267

27044

Gene nameArfGAP with FG repeats 1staphylococcal nuclease and tudor domain containing 1
SynonymsHRB|RAB|RIPTDRD11|Tudor-SN|p100
Cytomap

2q36.3

7q32.1

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP domain and FG repeat-containing protein 1HIV-1 Rev-binding proteinRab, Rev/Rex activation domain-binding proteinarf-GAP domain and FG repeats-containing protein 1hRIP, Rev interacting proteinnucleoporin-like protein RIPrev-interacting proteistaphylococcal nuclease domain-containing protein 1EBNA2 coactivator p100testis tissue sperm-binding protein Li 82Ptudor domain-containing protein 11
Modification date2020031320200313
UniProtAcc

P52594

Main function of 5'-partner protein: FUNCTION: Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. {ECO:0000250, ECO:0000269|PubMed:10613896, ECO:0000269|PubMed:14701878, ECO:0000269|PubMed:15749819}.

Q7KZF4

Main function of 5'-partner protein: FUNCTION: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:28546213, PubMed:18453631). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity). {ECO:0000250|UniProtKB:Q78PY7, ECO:0000269|PubMed:12234934, ECO:0000269|PubMed:18453631, ECO:0000269|PubMed:28546213, ECO:0000269|PubMed:9809063}.; FUNCTION: (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). {ECO:0000269|PubMed:7651391}.
Ensembl transtripts involved in fusion geneENST idsENST00000310078, ENST00000373671, 
ENST00000409171, ENST00000409315, 
ENST00000409979, ENST00000486932, 
ENST00000467238, ENST00000354725, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 9 X 8=93629 X 24 X 11=7656
# samples 1533
** MAII scorelog2(15/936*10)=-2.64154602908752
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(33/7656*10)=-4.53605290024021
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: AGFG1 [Title/Abstract] AND SND1 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: AGFG1 [Title/Abstract] AND SND1 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)AGFG1(228356356)-SND1(127484377), # samples:1
Anticipated loss of major functional domain due to fusion event.AGFG1-SND1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AGFG1-SND1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AGFG1-SND1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AGFG1-SND1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSND1

GO:0010587

miRNA catabolic process

28546213



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:228356356/chr7:127484377)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across AGFG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SND1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000409979AGFG1chr2228356356+ENST00000354725SND1chr7127484377+2571531452021658
ENST00000310078AGFG1chr2228356356+ENST00000354725SND1chr7127484377+2561521352011658
ENST00000409315AGFG1chr2228356356+ENST00000354725SND1chr7127484377+2354314231804593
ENST00000373671AGFG1chr2228356356+ENST00000354725SND1chr7127484377+2351311201801593
ENST00000409171AGFG1chr2228356356+ENST00000354725SND1chr7127484377+2351311201801593

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409979ENST00000354725AGFG1chr2228356356+SND1chr7127484377+0.0041632580.99583673
ENST00000310078ENST00000354725AGFG1chr2228356356+SND1chr7127484377+0.0040918170.99590814
ENST00000409315ENST00000354725AGFG1chr2228356356+SND1chr7127484377+0.0050740280.994926
ENST00000373671ENST00000354725AGFG1chr2228356356+SND1chr7127484377+0.0049292140.9950708
ENST00000409171ENST00000354725AGFG1chr2228356356+SND1chr7127484377+0.0049292140.9950708

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for AGFG1-SND1

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
AGFG1chr2228356356SND1chr712748437731197QQEIEFLQKHGNEVNVTVDYIRPASP
AGFG1chr2228356356SND1chr712748437731497QQEIEFLQKHGNEVNVTVDYIRPASP
AGFG1chr2228356356SND1chr7127484377521162QQEIEFLQKHGNEVNVTVDYIRPASP
AGFG1chr2228356356SND1chr7127484377531162QQEIEFLQKHGNEVNVTVDYIRPASP

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Potential FusionNeoAntigen Information of AGFG1-SND1 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
AGFG1-SND1_228356356_127484377.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
AGFG1-SND1chr2228356356chr7127484377521HLA-B44:03NEVNVTVDY0.99740.82481120
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:22FLQKHGNEV0.99710.7782514
AGFG1-SND1chr2228356356chr7127484377521HLA-B18:01NEVNVTVDY0.99560.5341120
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:60FLQKHGNEV0.99510.7447514
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:11FLQKHGNEV0.99490.7923514
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:67FLQKHGNEV0.99490.7465514
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:30FLQKHGNEV0.99490.7465514
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:24FLQKHGNEV0.99490.7465514
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:21FLQKHGNEV0.99330.8375514
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:27FLQKHGNEV0.99210.7576514
AGFG1-SND1chr2228356356chr7127484377521HLA-B51:02HGNEVNVTV0.99030.8296918
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:13FLQKHGNEV0.9880.8459514
AGFG1-SND1chr2228356356chr7127484377521HLA-B08:09FLQKHGNEV0.98760.8922514
AGFG1-SND1chr2228356356chr7127484377521HLA-B08:01FLQKHGNEV0.98740.8838514
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:04FLQKHGNEV0.98520.9578514
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:16FLQKHGNEV0.98420.6771514
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:35FLQKHGNEV0.97720.7653514
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:17FLQKHGNEV0.97290.8356514
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:19FLQKHGNEV0.96620.6553514
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:38FLQKHGNEV0.95640.8413514
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:29FLQKHGNEV0.92630.7468514
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:20FLQKHGNEV0.89110.7549514
AGFG1-SND1chr2228356356chr7127484377521HLA-B38:01KHGNEVNVTV0.97280.9934818
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:02FLQKHGNEV0.99710.7215514
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:05FLQKHGNEV0.99630.8198514
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:07FLQKHGNEV0.99490.7646514
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:01FLQKHGNEV0.99490.7465514
AGFG1-SND1chr2228356356chr7127484377521HLA-C05:09FLQKHGNEV0.99330.9903514
AGFG1-SND1chr2228356356chr7127484377521HLA-C04:06FLQKHGNEV0.930.9626514
AGFG1-SND1chr2228356356chr7127484377521HLA-C08:03HGNEVNVTV0.77270.9952918
AGFG1-SND1chr2228356356chr7127484377521HLA-C02:06HGNEVNVTV0.64590.986918
AGFG1-SND1chr2228356356chr7127484377521HLA-B51:08HGNEVNVTV0.53860.708918
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:03FLQKHGNEV0.99760.827514
AGFG1-SND1chr2228356356chr7127484377521HLA-B18:04NEVNVTVDY0.99740.56961120
AGFG1-SND1chr2228356356chr7127484377521HLA-B44:07NEVNVTVDY0.99740.82481120
AGFG1-SND1chr2228356356chr7127484377521HLA-B44:26NEVNVTVDY0.99740.82481120
AGFG1-SND1chr2228356356chr7127484377521HLA-B44:13NEVNVTVDY0.99740.82481120
AGFG1-SND1chr2228356356chr7127484377521HLA-B18:07NEVNVTVDY0.99660.54851120
AGFG1-SND1chr2228356356chr7127484377521HLA-B18:05NEVNVTVDY0.99560.5341120
AGFG1-SND1chr2228356356chr7127484377521HLA-B18:06NEVNVTVDY0.99350.51561120
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:06FLQKHGNEV0.99330.8375514
AGFG1-SND1chr2228356356chr7127484377521HLA-C05:01FLQKHGNEV0.99330.9903514
AGFG1-SND1chr2228356356chr7127484377521HLA-A02:14FLQKHGNEV0.99330.8311514
AGFG1-SND1chr2228356356chr7127484377521HLA-C18:01FLQKHGNEV0.99010.9565514
AGFG1-SND1chr2228356356chr7127484377521HLA-B08:18FLQKHGNEV0.98740.8838514
AGFG1-SND1chr2228356356chr7127484377521HLA-B18:03NEVNVTVDY0.98660.52491120
AGFG1-SND1chr2228356356chr7127484377521HLA-B51:05HGNEVNVTV0.96740.6957918
AGFG1-SND1chr2228356356chr7127484377521HLA-B59:01HGNEVNVTV0.92920.6796918
AGFG1-SND1chr2228356356chr7127484377521HLA-B18:11NEVNVTVDY0.89390.53061120
AGFG1-SND1chr2228356356chr7127484377521HLA-C01:03FLQKHGNEV0.88960.9743514
AGFG1-SND1chr2228356356chr7127484377521HLA-C08:01HGNEVNVTV0.77270.9952918
AGFG1-SND1chr2228356356chr7127484377521HLA-B51:09HGNEVNVTV0.74010.7892918
AGFG1-SND1chr2228356356chr7127484377521HLA-B08:12FLQKHGNEV0.60380.9175514
AGFG1-SND1chr2228356356chr7127484377521HLA-B35:20NEVNVTVDY0.41680.7481120
AGFG1-SND1chr2228356356chr7127484377521HLA-C07:04FLQKHGNEV0.2110.9754514
AGFG1-SND1chr2228356356chr7127484377521HLA-B07:13FLQKHGNEV0.18390.8892514
AGFG1-SND1chr2228356356chr7127484377521HLA-B48:02NEVNVTVDY0.05570.68041120
AGFG1-SND1chr2228356356chr7127484377521HLA-B38:05KHGNEVNVTV0.97280.9934818

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Potential FusionNeoAntigen Information of AGFG1-SND1 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
AGFG1-SND1_228356356_127484377.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
AGFG1-SND1chr2228356356chr7127484377521DRB1-0103EIEFLQKHGNEVNVT217
AGFG1-SND1chr2228356356chr7127484377521DRB1-0103QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-0103QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0103IEFLQKHGNEVNVTV318
AGFG1-SND1chr2228356356chr7127484377521DRB1-0109EIEFLQKHGNEVNVT217
AGFG1-SND1chr2228356356chr7127484377521DRB1-0109QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-0115EIEFLQKHGNEVNVT217
AGFG1-SND1chr2228356356chr7127484377521DRB1-0115QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-0422NEVNVTVDYIRPASP1126
AGFG1-SND1chr2228356356chr7127484377521DRB1-0802QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0803QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0804QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0806QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0807QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0807QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-0807EIEFLQKHGNEVNVT217
AGFG1-SND1chr2228356356chr7127484377521DRB1-0808QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0808QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-0809QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0810QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0811QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0811QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-0812QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0813QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0813QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-0814QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0815QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0815QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-0815EIEFLQKHGNEVNVT217
AGFG1-SND1chr2228356356chr7127484377521DRB1-0819EIEFLQKHGNEVNVT217
AGFG1-SND1chr2228356356chr7127484377521DRB1-0819QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-0819QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0820QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0821QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0822QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0823QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0824QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0827QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0828QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0828QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-0830QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0830QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-0830EIEFLQKHGNEVNVT217
AGFG1-SND1chr2228356356chr7127484377521DRB1-0831QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0832QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0832QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-0833QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0834EIEFLQKHGNEVNVT217
AGFG1-SND1chr2228356356chr7127484377521DRB1-0834QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-0834QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0835QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0836QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0837QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-0837QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-0838QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1101QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1102QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1103QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1104QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1105QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1106QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1108QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1109QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1110QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1111QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1112QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1113QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1115QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1116QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1118QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1119QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1124QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1125QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1127QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1128QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1129QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1131QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1132QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1133QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1134QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1135QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1136QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1137QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1138QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1139QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1141QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1142QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1143QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1144QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1145QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1146QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1147QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1148QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1149QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1150QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1151QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1154QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1155QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1156QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1157QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1158QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1159QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1160QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1161QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1162QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1163QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1164QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1165QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1166QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1167QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1167QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-1168QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1169QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1170QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1172QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1174QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1175QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1176QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1177QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1178QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1180QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1181QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1183QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1184QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1185QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1186QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1187QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1188QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1189QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1190QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1191QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1192QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1192QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-1194QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1195QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1196QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1204QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1204QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-1209QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1209QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-1220QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1301QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1304QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1305QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1306QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1307QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1308QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1309QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-13100QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1311QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1314QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1315QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1316QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1317QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1318QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1319QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1320QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1322QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1324QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1326QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1327QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1329QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1331EIEFLQKHGNEVNVT217
AGFG1-SND1chr2228356356chr7127484377521DRB1-1331QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-1331QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1332QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1335QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1336QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1342QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1343QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1344QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1346QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1347QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1348QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1349QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1350QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1351QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1352QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1353QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1354QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1355QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1356QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1357QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1358QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1359QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1362QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1363QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1364QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1367EIEFLQKHGNEVNVT217
AGFG1-SND1chr2228356356chr7127484377521DRB1-1367QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-1367QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1368QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1369QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1370QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1371QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1372QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1375QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1378QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1379QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1380QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1382QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1383QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1384QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1386QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1387QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1391QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1392QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1393QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1398QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1402QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1403QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1403QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-1403EIEFLQKHGNEVNVT217
AGFG1-SND1chr2228356356chr7127484377521DRB1-1406QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1412QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1413QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1415QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1417QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1420QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1422QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1424QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1425QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1427QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1429QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1437QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1440QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1440QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-1440EIEFLQKHGNEVNVT217
AGFG1-SND1chr2228356356chr7127484377521DRB1-1441QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1452QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1453QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1463QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1463QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-1467QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1467QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-1467EIEFLQKHGNEVNVT217
AGFG1-SND1chr2228356356chr7127484377521DRB1-1473QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1474QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1477QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1477QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-1477EIEFLQKHGNEVNVT217
AGFG1-SND1chr2228356356chr7127484377521DRB1-1478QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1480QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1481QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1483QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1484QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1485QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1489QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1489QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-1489EIEFLQKHGNEVNVT217
AGFG1-SND1chr2228356356chr7127484377521DRB1-1494QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1498QQEIEFLQKHGNEVN015
AGFG1-SND1chr2228356356chr7127484377521DRB1-1498QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-1515EIEFLQKHGNEVNVT217
AGFG1-SND1chr2228356356chr7127484377521DRB1-1604EIEFLQKHGNEVNVT217
AGFG1-SND1chr2228356356chr7127484377521DRB1-1604QEIEFLQKHGNEVNV116
AGFG1-SND1chr2228356356chr7127484377521DRB1-1610EIEFLQKHGNEVNVT217

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Fusion breakpoint peptide structures of AGFG1-SND1

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
5462LQKHGNEVNVTVDYAGFG1SND1chr2228356356chr7127484377521

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of AGFG1-SND1

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN5462LQKHGNEVNVTVDY-7.9962-8.1096
HLA-B14:023BVN5462LQKHGNEVNVTVDY-5.70842-6.74372
HLA-B52:013W395462LQKHGNEVNVTVDY-6.83737-6.95077
HLA-B52:013W395462LQKHGNEVNVTVDY-4.4836-5.5189
HLA-A11:014UQ25462LQKHGNEVNVTVDY-10.0067-10.1201
HLA-A11:014UQ25462LQKHGNEVNVTVDY-9.03915-10.0745
HLA-A24:025HGA5462LQKHGNEVNVTVDY-6.56204-6.67544
HLA-A24:025HGA5462LQKHGNEVNVTVDY-5.42271-6.45801
HLA-B44:053DX85462LQKHGNEVNVTVDY-7.85648-8.89178
HLA-B44:053DX85462LQKHGNEVNVTVDY-5.3978-5.5112
HLA-A02:016TDR5462LQKHGNEVNVTVDY-3.37154-4.40684

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Vaccine Design for the FusionNeoAntigens of AGFG1-SND1

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
AGFG1-SND1chr2228356356chr71274843771120NEVNVTVDYAATGAAGTCAATGTGACGGTGGACTAC
AGFG1-SND1chr2228356356chr7127484377514FLQKHGNEVTTCTTACAAAAACATGGAAATGAAGTC
AGFG1-SND1chr2228356356chr7127484377818KHGNEVNVTVAAACATGGAAATGAAGTCAATGTGACGGTG
AGFG1-SND1chr2228356356chr7127484377918HGNEVNVTVCATGGAAATGAAGTCAATGTGACGGTG

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
AGFG1-SND1chr2228356356chr7127484377015QQEIEFLQKHGNEVNCAACAGGAAATTGAATTCTTACAAAAACATGGAAATGAAGTCAAT
AGFG1-SND1chr2228356356chr7127484377116QEIEFLQKHGNEVNVCAGGAAATTGAATTCTTACAAAAACATGGAAATGAAGTCAATGTG
AGFG1-SND1chr2228356356chr71274843771126NEVNVTVDYIRPASPAATGAAGTCAATGTGACGGTGGACTACATTAGACCAGCCAGCCCA
AGFG1-SND1chr2228356356chr7127484377217EIEFLQKHGNEVNVTGAAATTGAATTCTTACAAAAACATGGAAATGAAGTCAATGTGACG
AGFG1-SND1chr2228356356chr7127484377318IEFLQKHGNEVNVTVATTGAATTCTTACAAAAACATGGAAATGAAGTCAATGTGACGGTG

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Information of the samples that have these potential fusion neoantigens of AGFG1-SND1

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
STADAGFG1-SND1chr2228356356ENST00000310078chr7127484377ENST00000354725TCGA-D7-8576-01A

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Potential target of CAR-T therapy development for AGFG1-SND1

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to AGFG1-SND1

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to AGFG1-SND1

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSND1C0004352Autistic Disorder1CTD_human
TgeneSND1C0024121Lung Neoplasms1CTD_human
TgeneSND1C0242379Malignant neoplasm of lung1CTD_human