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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:GFPT2-PPFIA2

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GFPT2-PPFIA2
FusionPDB ID: 32979
FusionGDB2.0 ID: 32979
HgeneTgene
Gene symbol

GFPT2

PPFIA2

Gene ID

9945

8499

Gene nameglutamine-fructose-6-phosphate transaminase 2PTPRF interacting protein alpha 2
SynonymsGFAT|GFAT 2|GFAT2-
Cytomap

5q35.3

12q21.31

Type of geneprotein-codingprotein-coding
Descriptionglutamine--fructose-6-phosphate aminotransferase [isomerizing] 2D-fructose-6-phosphate amidotransferase 2glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2glutamine: fructose-6-phosphate aminotransferase 2glutamine:fructose-6-phosphateliprin-alpha-2protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Modification date2020031320200313
UniProtAcc

O94808

Main function of 5'-partner protein: FUNCTION: Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.
.
Ensembl transtripts involved in fusion geneENST idsENST00000253778, ENST00000520165, 
ENST00000541017, ENST00000333447, 
ENST00000407050, ENST00000443686, 
ENST00000541570, ENST00000545296, 
ENST00000548586, ENST00000550359, 
ENST00000552948, ENST00000549325, 
ENST00000549396, ENST00000550584, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 5 X 3=6017 X 12 X 4=816
# samples 516
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(16/816*10)=-2.35049724708413
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: GFPT2 [Title/Abstract] AND PPFIA2 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: GFPT2 [Title/Abstract] AND PPFIA2 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GFPT2(179757700)-PPFIA2(81747118), # samples:2
Anticipated loss of major functional domain due to fusion event.GFPT2-PPFIA2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GFPT2-PPFIA2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GFPT2-PPFIA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GFPT2-PPFIA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:179757700/chr12:81747118)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across GFPT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPFIA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000253778GFPT2chr5179757700-ENST00000549396PPFIA2chr1281747118-4133704532704883
ENST00000253778GFPT2chr5179757700-ENST00000550584PPFIA2chr1281747118-4040704532674873
ENST00000253778GFPT2chr5179757700-ENST00000549325PPFIA2chr1281747118-3439704532683876

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000253778ENST00000549396GFPT2chr5179757700-PPFIA2chr1281747118-0.0006144530.9993855
ENST00000253778ENST00000550584GFPT2chr5179757700-PPFIA2chr1281747118-0.0006109440.99938905
ENST00000253778ENST00000549325GFPT2chr5179757700-PPFIA2chr1281747118-0.0010254710.99897456

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for GFPT2-PPFIA2

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
GFPT2chr5179757700PPFIA2chr1281747118704217TFSTLVERVIQQLVKSLGDHEWNRTQ

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Potential FusionNeoAntigen Information of GFPT2-PPFIA2 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
GFPT2-PPFIA2_179757700_81747118.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B52:01IQQLVKSL0.74990.8067917
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B41:01VERVIQQLV0.59330.8351514
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B08:01VIQQLVKSL0.47840.7641817
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B50:01VERVIQQLV0.44790.7435514
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B52:01VERVIQQLV0.41580.9786514
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B57:01LVKSLGDHEW0.99960.99751222
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B58:02LVKSLGDHEW0.99860.9961222
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B58:01LVKSLGDHEW0.99750.99631222
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B57:03LVKSLGDHEW0.99330.99911222
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B40:06VERVIQQLV0.99790.8562514
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B51:07VERVIQQLV0.36470.9051514
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-C03:05VIQQLVKSL0.96940.8794817
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B15:73VIQQLVKSL0.73580.8174817
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B15:30VIQQLVKSL0.63610.7354817
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B08:18VIQQLVKSL0.47840.7641817
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B50:04VERVIQQLV0.44790.7435514
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B50:05VERVIQQLV0.44790.7435514
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B08:12VIQQLVKSL0.36310.8607817
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B57:10LVKSLGDHEW0.99960.99751222
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B57:04LVKSLGDHEW0.99890.9721222
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B58:06LVKSLGDHEW0.99820.99481222
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B15:24LVKSLGDHEW0.99370.99461222
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B57:02LVKSLGDHEW0.99090.99581222
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-A32:01RVIQQLVKSL0.98420.9531717
GFPT2-PPFIA2chr5179757700chr1281747118704HLA-B15:13LVKSLGDHEW0.98090.94321222

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Potential FusionNeoAntigen Information of GFPT2-PPFIA2 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
GFPT2-PPFIA2_179757700_81747118.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0802ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0804ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0804VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0804LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0804RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0806ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0806VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0809ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0810ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0813ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0820ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0820VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0820LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0820RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0821ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0822ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0822VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0824ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0824VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0828ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0828VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0828LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0828RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0831ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0831VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0831LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-0831RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1101ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1101VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1103ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1104ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1104VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1104LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1104RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1105ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1105VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1106ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1106VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1106LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1106RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1108ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1109ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1109VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1110ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1110VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1112ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1112VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1113ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1113VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1115ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1115VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1118ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1118VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1118LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1118RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1119ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1124ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1124VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1125ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1125VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1127ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1127VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1128ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1128VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1129ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1129VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1131ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1132ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1132VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1133ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1133VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1134ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1134VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1134LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1135ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1135VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1135LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1135RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1137ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1137VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1138ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1138VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1138LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1138RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1139ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1139VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1141ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1142ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1142VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1142LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1142RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1143ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1143VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1143LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1143RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1144ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1144VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1144LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1144RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1146ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1146VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1146LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1146RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1147ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1147VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1147LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1147RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1149ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1149VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1150ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1150VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1150LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1150RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1151ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1151VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1154ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1154VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1156ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1156VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1156LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1156RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1157ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1157VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1157LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1157RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1158ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1158VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1158LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1158RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1159ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1160ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1160VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1160LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1160RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1161ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1161VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1162ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1162VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1163ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1166ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1166VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1167ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1167VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1167LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1167RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1172ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1172VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1174ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1174VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1175ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1175VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1176ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1177ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1177VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1177LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1177RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1178ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1178VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1178LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1178RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1180ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1180VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1181ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1181VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1183ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1183VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1183LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1183RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1184ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1184VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1184LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1184RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1185ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1187ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1187VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1188ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1188VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1188LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1188RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1189ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1190ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1190VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1191ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1191VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1192ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1192VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1192RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1192LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1193ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1194ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1194VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1195ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1195VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1196ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1196VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1204ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1204VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1204LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1204RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1209ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1209VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1209LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1209RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1220ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1220VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1305ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1305VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1306ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1306VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1306LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1306RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1307ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1307VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1309ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-13100ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1311ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1311VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1311LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1311RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1314ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1314VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1318ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1318VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1324ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1326ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1326VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1342ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1342VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1342LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1342RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1344ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1344VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1344LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1346ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1347ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1350ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1350VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1356ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1358ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1360ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1362ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1362VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1377ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1382ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1402ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1406ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1406VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1409ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1411ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1412ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1412VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1415ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1415VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1415LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1415RVIQQLVKSLGDHEW722
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1417ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1417VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1417LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1420ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1420VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1421ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1421VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1422ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1425ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1427ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1429ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1429VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1430ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1431ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1431VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1433ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1434ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1434VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1437ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1441ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1452ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1452VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1452LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1465ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1473ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1473VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1474ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1474VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1478ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1480ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1480VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1480LVERVIQQLVKSLGD419
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1481ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1481VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1483ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1483VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1484ERVIQQLVKSLGDHE621
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1484VERVIQQLVKSLGDH520
GFPT2-PPFIA2chr5179757700chr1281747118704DRB1-1494ERVIQQLVKSLGDHE621

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Fusion breakpoint peptide structures of GFPT2-PPFIA2

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
2110ERVIQQLVKSLGDHGFPT2PPFIA2chr5179757700chr1281747118704

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of GFPT2-PPFIA2

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN2110ERVIQQLVKSLGDH-7.15543-7.26883
HLA-B14:023BVN2110ERVIQQLVKSLGDH-4.77435-5.80965
HLA-B52:013W392110ERVIQQLVKSLGDH-6.80875-6.92215
HLA-B52:013W392110ERVIQQLVKSLGDH-4.20386-5.23916
HLA-A11:014UQ22110ERVIQQLVKSLGDH-7.5194-8.5547
HLA-A11:014UQ22110ERVIQQLVKSLGDH-6.9601-7.0735
HLA-A24:025HGA2110ERVIQQLVKSLGDH-7.52403-7.63743
HLA-A24:025HGA2110ERVIQQLVKSLGDH-5.82433-6.85963
HLA-B27:056PYJ2110ERVIQQLVKSLGDH-3.28285-4.31815
HLA-B44:053DX82110ERVIQQLVKSLGDH-5.91172-6.94702
HLA-B44:053DX82110ERVIQQLVKSLGDH-4.24346-4.35686

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Vaccine Design for the FusionNeoAntigens of GFPT2-PPFIA2

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
GFPT2-PPFIA2chr5179757700chr12817471181222LVKSLGDHEWTTGGTGAAATCTCTTGGGGATCACGAGTGG
GFPT2-PPFIA2chr5179757700chr1281747118514VERVIQQLVGTCGAGAGAGTCATTCAGCAGTTGGTG
GFPT2-PPFIA2chr5179757700chr1281747118717RVIQQLVKSLAGAGTCATTCAGCAGTTGGTGAAATCTCTT
GFPT2-PPFIA2chr5179757700chr1281747118817VIQQLVKSLGTCATTCAGCAGTTGGTGAAATCTCTT
GFPT2-PPFIA2chr5179757700chr1281747118917IQQLVKSLATTCAGCAGTTGGTGAAATCTCTT

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
GFPT2-PPFIA2chr5179757700chr1281747118419LVERVIQQLVKSLGDTTGGTCGAGAGAGTCATTCAGCAGTTGGTGAAATCTCTTGGGGAT
GFPT2-PPFIA2chr5179757700chr1281747118520VERVIQQLVKSLGDHGTCGAGAGAGTCATTCAGCAGTTGGTGAAATCTCTTGGGGATCAC
GFPT2-PPFIA2chr5179757700chr1281747118621ERVIQQLVKSLGDHEGAGAGAGTCATTCAGCAGTTGGTGAAATCTCTTGGGGATCACGAG
GFPT2-PPFIA2chr5179757700chr1281747118722RVIQQLVKSLGDHEWAGAGTCATTCAGCAGTTGGTGAAATCTCTTGGGGATCACGAGTGG

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Information of the samples that have these potential fusion neoantigens of GFPT2-PPFIA2

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
SARCGFPT2-PPFIA2chr5179757700ENST00000253778chr1281747118ENST00000549325TCGA-3B-A9HS-01A

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Potential target of CAR-T therapy development for GFPT2-PPFIA2

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to GFPT2-PPFIA2

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GFPT2-PPFIA2

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource