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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:HMG20B-CNOT3

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: HMG20B-CNOT3
FusionPDB ID: 36795
FusionGDB2.0 ID: 36795
HgeneTgene
Gene symbol

HMG20B

CNOT3

Gene ID

10362

4849

Gene namehigh mobility group 20BCCR4-NOT transcription complex subunit 3
SynonymsBRAF25|BRAF35|HMGX2|HMGXB2|PP7706|SMARCE1r|SOXL|pp8857IDDSADF|LENG2|NOT3|NOT3H
Cytomap

19p13.3

19q13.42

Type of geneprotein-codingprotein-coding
DescriptionSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-relatedBRCA2-associated factor 35HMG box domain containing 2HMG box-containing protein 20BHMG domain-containing protein 2HMG domain-containing protein HMGX2CCR4-NOT transcription complex subunit 3CCR4-associated factor 3NOT3 (negative regulator of transcription 3, yeast) homologleukocyte receptor cluster member 2
Modification date2020032720200313
UniProtAcc

Q9P0W2

Main function of 5'-partner protein: FUNCTION: Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.

O75175

Main function of 5'-partner protein: FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:22342980, ECO:0000269|PubMed:22367759}.
Ensembl transtripts involved in fusion geneENST idsENST00000585741, ENST00000333651, 
ENST00000221232, ENST00000496327, 
ENST00000358389, ENST00000406403, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 3 X 4=485 X 5 X 4=100
# samples 45
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: HMG20B [Title/Abstract] AND CNOT3 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: HMG20B [Title/Abstract] AND CNOT3 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)HMG20B(3573798)-CNOT3(54657451), # samples:1
Anticipated loss of major functional domain due to fusion event.HMG20B-CNOT3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HMG20B-CNOT3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HMG20B-CNOT3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HMG20B-CNOT3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:3573798/chr19:54657451)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across HMG20B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CNOT3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000333651HMG20Bchr193573798+ENST00000221232CNOT3chr1954657451+72122212446144

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000333651ENST00000221232HMG20Bchr193573798+CNOT3chr1954657451+0.021259810.9787402

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for HMG20B-CNOT3

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
HMG20Bchr193573798CNOT3chr195465745122253PGQHGGFVVTVKQERGEGPRAGEKGS

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Potential FusionNeoAntigen Information of HMG20B-CNOT3 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
HMG20B-CNOT3_3573798_54657451.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
HMG20B-CNOT3chr193573798chr1954657451222HLA-B45:01QERGEGPRA0.99730.97571221
HMG20B-CNOT3chr193573798chr1954657451222HLA-B50:02QERGEGPRA0.9890.82861221
HMG20B-CNOT3chr193573798chr1954657451222HLA-B41:01QERGEGPRA0.51710.92951221
HMG20B-CNOT3chr193573798chr1954657451222HLA-B50:01QERGEGPRA0.21550.98461221
HMG20B-CNOT3chr193573798chr1954657451222HLA-B50:01KQERGEGPRA0.54820.89871121
HMG20B-CNOT3chr193573798chr1954657451222HLA-B40:06QERGEGPRA0.99660.83141221
HMG20B-CNOT3chr193573798chr1954657451222HLA-B50:04QERGEGPRA0.21550.98461221
HMG20B-CNOT3chr193573798chr1954657451222HLA-B50:05QERGEGPRA0.21550.98461221
HMG20B-CNOT3chr193573798chr1954657451222HLA-B50:04KQERGEGPRA0.54820.89871121
HMG20B-CNOT3chr193573798chr1954657451222HLA-B50:05KQERGEGPRA0.54820.89871121

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Potential FusionNeoAntigen Information of HMG20B-CNOT3 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
HMG20B-CNOT3_3573798_54657451.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0305HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0305QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0340HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0340QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0340GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0340GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0466HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0802HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0803HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0806GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0808HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0809HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0811HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0813HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0813QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0813GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0814HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0815HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0815QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0815GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0821HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0822GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0823HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0824HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0827HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0829HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0829QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0830HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0830QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0830GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0831GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0832HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0833HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0835HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0836HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0837HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0837QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0837GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0838HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-0840HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1101HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1101QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1105HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1105QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1108HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1108QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1108GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1108GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1109HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1109QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1110HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1110QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1111HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1111QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1111GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1111GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1112HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1112QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1114HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1114QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1114GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1114GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1115HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1115QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1119HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1119QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1119GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1119GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1120HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1120QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1120GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1120GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1124HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1124QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1127HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1127QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1127GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1128HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1128QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1129HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1129QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1131HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1131QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1131GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1131GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1132HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1132QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1133HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1133QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1134HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1137HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1139HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1139QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1145HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1145QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1145GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1145GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1149HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1149QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1151HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1151QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1153HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1153QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1153GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1153GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1161HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1161QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1162HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1162QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1164HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1164QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1164GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1164GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1166HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1166QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1168HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1168QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1168GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1168GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1169HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1169QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1169GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1169GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1172HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1172QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1172GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1172GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1173HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1173QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1173GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1173GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1174HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1174QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1175HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1175QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1179HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1179QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1179GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1179GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1180HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1180QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1181HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1182HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1182QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1182GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1182GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1183HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1186HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1186QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1186GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1186GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1187HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1187QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1190HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1190QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1191HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1191QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1192HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1193HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1193QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1194HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1194QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1195HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1195QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1196HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1196QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1220GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1302HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1302QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1302GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1302GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1305HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1305QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1307HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-13100HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-13100QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-13101HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-13101QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1310HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1310QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1313HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1313QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1314HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1314QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1316HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1316QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1316GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1316GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1317HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1321HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1323HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1323QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1323GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1323GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1326HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1326QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1327HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1329HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1329QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1329GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1329GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1330HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1330QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1331HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1331QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1333HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1333QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1334HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1334QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1334GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1334GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1336HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1336QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1336GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1336GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1337HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1337QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1337GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1337GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1338HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1338QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1338GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1338GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1339HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1339QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1339GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1339GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1341HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1341QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1341GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1341GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1343HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1344HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1346HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1346QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1347HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1350HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1350QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1356HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1356QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1356GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1356GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1360HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1360QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1360GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1361HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1362HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1362QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1363HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1363QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1363GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1363GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1365HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1365QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1365GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1365GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1366HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1366QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1366GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1367HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1367QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1371HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1373HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1373QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1373GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1373GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1374HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1374QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1374GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1374GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1376HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1382HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1382QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1382GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1382GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1385HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1385QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1385GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1385GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1386HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1386QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1386GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1386GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1396HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1396QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1396GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1396GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1397HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1397QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1397GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1397GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1399HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1399QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1399GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1399GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1402HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1402QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1402GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1402GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1403HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1403QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1403GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1403GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1406HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1407HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1407QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1409HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1409QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1409GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1409GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1411HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1412HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1413HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1413QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1413GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1413GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1414HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1414QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1414GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1414GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1417HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1419HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1419QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1419GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1419GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1420HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1421HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1422HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1424HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1424QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1424GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1424GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1425HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1427HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1427QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1430HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1430QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1430GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1430GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1433HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1433QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1436HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1436QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1436GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1436GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1440HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1440QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1440GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1440GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1441HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1441QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1441GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1441GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1442HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1442QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1442GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1442GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1444HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1444QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1444GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1444GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1446HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1446QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1447HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1447QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1447GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1447GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1449HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1449QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1451HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1451QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1451GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1451GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1452HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1453HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1453QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1463HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1463QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1463GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1463GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1467HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1467QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1467GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1467GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1468HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1468QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1469HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1469QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1477HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1477QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1477GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1477GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1480HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1481HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1483HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1484HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1485HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1485QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1485GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1485GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1489HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1489QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1489GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1489GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1493HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1493QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1494HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1494QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1494GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1494GQHGGFVVTVKQERG116
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1495HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1495QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1498HGGFVVTVKQERGEG318
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1498QHGGFVVTVKQERGE217
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1498GGFVVTVKQERGEGP419
HMG20B-CNOT3chr193573798chr1954657451222DRB1-1498GQHGGFVVTVKQERG116

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Fusion breakpoint peptide structures of HMG20B-CNOT3

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
2613FVVTVKQERGEGPRHMG20BCNOT3chr193573798chr1954657451222

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of HMG20B-CNOT3

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN2613FVVTVKQERGEGPR-7.15543-7.26883
HLA-B14:023BVN2613FVVTVKQERGEGPR-4.77435-5.80965
HLA-B52:013W392613FVVTVKQERGEGPR-6.80875-6.92215
HLA-B52:013W392613FVVTVKQERGEGPR-4.20386-5.23916
HLA-A11:014UQ22613FVVTVKQERGEGPR-7.5194-8.5547
HLA-A11:014UQ22613FVVTVKQERGEGPR-6.9601-7.0735
HLA-A24:025HGA2613FVVTVKQERGEGPR-7.52403-7.63743
HLA-A24:025HGA2613FVVTVKQERGEGPR-5.82433-6.85963
HLA-B27:056PYJ2613FVVTVKQERGEGPR-3.28285-4.31815
HLA-B44:053DX82613FVVTVKQERGEGPR-5.91172-6.94702
HLA-B44:053DX82613FVVTVKQERGEGPR-4.24346-4.35686

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Vaccine Design for the FusionNeoAntigens of HMG20B-CNOT3

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
HMG20B-CNOT3chr193573798chr19546574511121KQERGEGPRAGAGGAGGGCACTAAGGCACAGTATCTGGCA
HMG20B-CNOT3chr193573798chr19546574511221QERGEGPRAGAGGGCACTAAGGCACAGTATCTGGCA

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
HMG20B-CNOT3chr193573798chr1954657451116GQHGGFVVTVKQERGCCACGCGCGGGCGAGAAGGGGTCCCACGAGGAGGAGGGCACTAAG
HMG20B-CNOT3chr193573798chr1954657451217QHGGFVVTVKQERGECGCGCGGGCGAGAAGGGGTCCCACGAGGAGGAGGGCACTAAGGCA
HMG20B-CNOT3chr193573798chr1954657451318HGGFVVTVKQERGEGGCGGGCGAGAAGGGGTCCCACGAGGAGGAGGGCACTAAGGCACAG
HMG20B-CNOT3chr193573798chr1954657451419GGFVVTVKQERGEGPGGCGAGAAGGGGTCCCACGAGGAGGAGGGCACTAAGGCACAGTAT

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Information of the samples that have these potential fusion neoantigens of HMG20B-CNOT3

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
BLCAHMG20B-CNOT3chr193573798ENST00000333651chr1954657451ENST00000221232TCGA-FD-A3B6

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Potential target of CAR-T therapy development for HMG20B-CNOT3

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to HMG20B-CNOT3

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to HMG20B-CNOT3

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource