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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:ILF3-SMARCA4

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ILF3-SMARCA4
FusionPDB ID: 39631
FusionGDB2.0 ID: 39631
HgeneTgene
Gene symbol

ILF3

SMARCA4

Gene ID

3609

6597

Gene nameinterleukin enhancer binding factor 3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SynonymsCBTF|DRBF|DRBP76|MMP4|MPHOSPH4|MPP4|MPP4110|NF-AT-90|NF110|NF110b|NF90|NF90a|NF90b|NF90c|NF90ctv|NFAR|NFAR-1|NFAR-2|NFAR110|NFAR2|NFAR90|TCP110|TCP80BAF190|BAF190A|BRG1|CSS4|MRD16|RTPS2|SNF2|SNF2-beta|SNF2L4|SNF2LB|SWI2|hSNF2b
Cytomap

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptioninterleukin enhancer-binding factor 3M phase phosphoprotein 4, nuclear factor associated with DS RNAM-phase phosphoprotein 4double-stranded RNA-binding protein, 76 kDdsRNA binding protein NFAR-2/MPP4interleukin enhancer binding factor 3, 90kDinterletranscription activator BRG1ATP-dependent helicase SMARCA4BRG1-associated factor 190ABRM/SWI2-related gene 1SNF2-like 4brahma protein-like 1global transcription activator homologous sequencehomeotic gene regulatormitotic growth and transcription a
Modification date2020032220200315
UniProtAcc

Q12906

Main function of 5'-partner protein: FUNCTION: RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.		.
Ensembl transtripts involved in fusion geneENST idsENST00000250241, ENST00000318511, 
ENST00000407004, ENST00000420083, 
ENST00000449870, ENST00000588657, 
ENST00000589998, ENST00000590261, 
ENST00000592763, ENST00000586544, 
ENST00000538456, ENST00000344626, 
ENST00000358026, ENST00000413806, 
ENST00000429416, ENST00000444061, 
ENST00000450717, ENST00000541122, 
ENST00000589677, ENST00000590574, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 15 X 11=379520 X 28 X 15=8400
# samples 3032
** MAII scorelog2(30/3795*10)=-3.66106547980695
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/8400*10)=-4.71424551766612
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: ILF3 [Title/Abstract] AND SMARCA4 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: ILF3 [Title/Abstract] AND SMARCA4 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ILF3(10782211)-SMARCA4(11134194), # samples:2
Anticipated loss of major functional domain due to fusion event.ILF3-SMARCA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ILF3-SMARCA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ILF3-SMARCA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ILF3-SMARCA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneILF3

GO:0006468

protein phosphorylation

21123651

HgeneILF3

GO:0045892

negative regulation of transcription, DNA-templated

11739746

HgeneILF3

GO:0045893

positive regulation of transcription, DNA-templated

11739746

TgeneSMARCA4

GO:0006337

nucleosome disassembly

8895581

TgeneSMARCA4

GO:0006338

chromatin remodeling

10943845|11726552

TgeneSMARCA4

GO:0045892

negative regulation of transcription, DNA-templated

12065415

TgeneSMARCA4

GO:0045944

positive regulation of transcription by RNA polymerase II

15774904|17938176

TgeneSMARCA4

GO:0051091

positive regulation of DNA-binding transcription factor activity

11950834|17938176

TgeneSMARCA4

GO:1902661

positive regulation of glucose mediated signaling pathway

22368283



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:10782211/chr19:11134194)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across ILF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SMARCA4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000420083ILF3chr1910782211+ENST00000358026SMARCA4chr1911134194+33757283172908863
ENST00000420083ILF3chr1910782211+ENST00000344626SMARCA4chr1911134194+30567283172812831
ENST00000420083ILF3chr1910782211+ENST00000429416SMARCA4chr1911134194+32797283172812831
ENST00000420083ILF3chr1910782211+ENST00000541122SMARCA4chr1911134194+27237283172722802
ENST00000420083ILF3chr1910782211+ENST00000589677SMARCA4chr1911134194+27207283172719801
ENST00000420083ILF3chr1910782211+ENST00000444061SMARCA4chr1911134194+27117283172710798
ENST00000420083ILF3chr1910782211+ENST00000590574SMARCA4chr1911134194+27147283172713799
ENST00000420083ILF3chr1910782211+ENST00000413806SMARCA4chr1911134194+31897283172722801
ENST00000420083ILF3chr1910782211+ENST00000450717SMARCA4chr1911134194+31867283172719800
ENST00000449870ILF3chr1910782211+ENST00000358026SMARCA4chr1911134194+33757283172908863
ENST00000449870ILF3chr1910782211+ENST00000344626SMARCA4chr1911134194+30567283172812831
ENST00000449870ILF3chr1910782211+ENST00000429416SMARCA4chr1911134194+32797283172812831
ENST00000449870ILF3chr1910782211+ENST00000541122SMARCA4chr1911134194+27237283172722802
ENST00000449870ILF3chr1910782211+ENST00000589677SMARCA4chr1911134194+27207283172719801
ENST00000449870ILF3chr1910782211+ENST00000444061SMARCA4chr1911134194+27117283172710798
ENST00000449870ILF3chr1910782211+ENST00000590574SMARCA4chr1911134194+27147283172713799
ENST00000449870ILF3chr1910782211+ENST00000413806SMARCA4chr1911134194+31897283172722801
ENST00000449870ILF3chr1910782211+ENST00000450717SMARCA4chr1911134194+31867283172719800
ENST00000318511ILF3chr1910782211+ENST00000358026SMARCA4chr1911134194+33757283172908863
ENST00000318511ILF3chr1910782211+ENST00000344626SMARCA4chr1911134194+30567283172812831
ENST00000318511ILF3chr1910782211+ENST00000429416SMARCA4chr1911134194+32797283172812831
ENST00000318511ILF3chr1910782211+ENST00000541122SMARCA4chr1911134194+27237283172722802
ENST00000318511ILF3chr1910782211+ENST00000589677SMARCA4chr1911134194+27207283172719801
ENST00000318511ILF3chr1910782211+ENST00000444061SMARCA4chr1911134194+27117283172710798
ENST00000318511ILF3chr1910782211+ENST00000590574SMARCA4chr1911134194+27147283172713799
ENST00000318511ILF3chr1910782211+ENST00000413806SMARCA4chr1911134194+31897283172722801
ENST00000318511ILF3chr1910782211+ENST00000450717SMARCA4chr1911134194+31867283172719800
ENST00000407004ILF3chr1910782211+ENST00000358026SMARCA4chr1911134194+33086612502841863
ENST00000407004ILF3chr1910782211+ENST00000344626SMARCA4chr1911134194+29896612502745831
ENST00000407004ILF3chr1910782211+ENST00000429416SMARCA4chr1911134194+32126612502745831
ENST00000407004ILF3chr1910782211+ENST00000541122SMARCA4chr1911134194+26566612502655802
ENST00000407004ILF3chr1910782211+ENST00000589677SMARCA4chr1911134194+26536612502652801
ENST00000407004ILF3chr1910782211+ENST00000444061SMARCA4chr1911134194+26446612502643798
ENST00000407004ILF3chr1910782211+ENST00000590574SMARCA4chr1911134194+26476612502646799
ENST00000407004ILF3chr1910782211+ENST00000413806SMARCA4chr1911134194+31226612502655801
ENST00000407004ILF3chr1910782211+ENST00000450717SMARCA4chr1911134194+31196612502652800
ENST00000589998ILF3chr1910782211+ENST00000358026SMARCA4chr1911134194+32756282172808863
ENST00000589998ILF3chr1910782211+ENST00000344626SMARCA4chr1911134194+29566282172712831
ENST00000589998ILF3chr1910782211+ENST00000429416SMARCA4chr1911134194+31796282172712831
ENST00000589998ILF3chr1910782211+ENST00000541122SMARCA4chr1911134194+26236282172622802
ENST00000589998ILF3chr1910782211+ENST00000589677SMARCA4chr1911134194+26206282172619801
ENST00000589998ILF3chr1910782211+ENST00000444061SMARCA4chr1911134194+26116282172610798
ENST00000589998ILF3chr1910782211+ENST00000590574SMARCA4chr1911134194+26146282172613799
ENST00000589998ILF3chr1910782211+ENST00000413806SMARCA4chr1911134194+30896282172622801
ENST00000589998ILF3chr1910782211+ENST00000450717SMARCA4chr1911134194+30866282172619800
ENST00000250241ILF3chr1910782211+ENST00000358026SMARCA4chr1911134194+3127480692660863
ENST00000250241ILF3chr1910782211+ENST00000344626SMARCA4chr1911134194+2808480692564831
ENST00000250241ILF3chr1910782211+ENST00000429416SMARCA4chr1911134194+3031480692564831
ENST00000250241ILF3chr1910782211+ENST00000541122SMARCA4chr1911134194+2475480692474801
ENST00000250241ILF3chr1910782211+ENST00000589677SMARCA4chr1911134194+2472480692471800
ENST00000250241ILF3chr1910782211+ENST00000444061SMARCA4chr1911134194+2463480692462797
ENST00000250241ILF3chr1910782211+ENST00000590574SMARCA4chr1911134194+2466480692465798
ENST00000250241ILF3chr1910782211+ENST00000413806SMARCA4chr1911134194+2941480692474801
ENST00000250241ILF3chr1910782211+ENST00000450717SMARCA4chr1911134194+2938480692471800
ENST00000592763ILF3chr1910782211+ENST00000358026SMARCA4chr1911134194+305841102591863
ENST00000592763ILF3chr1910782211+ENST00000344626SMARCA4chr1911134194+273941102495831
ENST00000592763ILF3chr1910782211+ENST00000429416SMARCA4chr1911134194+296241102495831
ENST00000592763ILF3chr1910782211+ENST00000541122SMARCA4chr1911134194+240641102405801
ENST00000592763ILF3chr1910782211+ENST00000589677SMARCA4chr1911134194+240341102402800
ENST00000592763ILF3chr1910782211+ENST00000444061SMARCA4chr1911134194+239441102393797
ENST00000592763ILF3chr1910782211+ENST00000590574SMARCA4chr1911134194+239741102396798
ENST00000592763ILF3chr1910782211+ENST00000413806SMARCA4chr1911134194+287241102405801
ENST00000592763ILF3chr1910782211+ENST00000450717SMARCA4chr1911134194+286941102402800
ENST00000588657ILF3chr1910782211+ENST00000358026SMARCA4chr1911134194+305841102591863
ENST00000588657ILF3chr1910782211+ENST00000344626SMARCA4chr1911134194+273941102495831
ENST00000588657ILF3chr1910782211+ENST00000429416SMARCA4chr1911134194+296241102495831
ENST00000588657ILF3chr1910782211+ENST00000541122SMARCA4chr1911134194+240641102405801
ENST00000588657ILF3chr1910782211+ENST00000589677SMARCA4chr1911134194+240341102402800
ENST00000588657ILF3chr1910782211+ENST00000444061SMARCA4chr1911134194+239441102393797
ENST00000588657ILF3chr1910782211+ENST00000590574SMARCA4chr1911134194+239741102396798
ENST00000588657ILF3chr1910782211+ENST00000413806SMARCA4chr1911134194+287241102405801
ENST00000588657ILF3chr1910782211+ENST00000450717SMARCA4chr1911134194+286941102402800
ENST00000590261ILF3chr1910782211+ENST00000358026SMARCA4chr1911134194+305841102591863
ENST00000590261ILF3chr1910782211+ENST00000344626SMARCA4chr1911134194+273941102495831
ENST00000590261ILF3chr1910782211+ENST00000429416SMARCA4chr1911134194+296241102495831
ENST00000590261ILF3chr1910782211+ENST00000541122SMARCA4chr1911134194+240641102405801
ENST00000590261ILF3chr1910782211+ENST00000589677SMARCA4chr1911134194+240341102402800
ENST00000590261ILF3chr1910782211+ENST00000444061SMARCA4chr1911134194+239441102393797
ENST00000590261ILF3chr1910782211+ENST00000590574SMARCA4chr1911134194+239741102396798
ENST00000590261ILF3chr1910782211+ENST00000413806SMARCA4chr1911134194+287241102405801
ENST00000590261ILF3chr1910782211+ENST00000450717SMARCA4chr1911134194+286941102402800
ENST00000420083ILF3chr1910782211+ENST00000358026SMARCA4chr1911134193+33757283172908863
ENST00000420083ILF3chr1910782211+ENST00000344626SMARCA4chr1911134193+30567283172812831
ENST00000420083ILF3chr1910782211+ENST00000429416SMARCA4chr1911134193+32797283172812831
ENST00000420083ILF3chr1910782211+ENST00000541122SMARCA4chr1911134193+27237283172722802
ENST00000420083ILF3chr1910782211+ENST00000589677SMARCA4chr1911134193+27207283172719801
ENST00000420083ILF3chr1910782211+ENST00000444061SMARCA4chr1911134193+27117283172710798
ENST00000420083ILF3chr1910782211+ENST00000590574SMARCA4chr1911134193+27147283172713799
ENST00000420083ILF3chr1910782211+ENST00000413806SMARCA4chr1911134193+31897283172722801
ENST00000420083ILF3chr1910782211+ENST00000450717SMARCA4chr1911134193+31867283172719800
ENST00000449870ILF3chr1910782211+ENST00000358026SMARCA4chr1911134193+33757283172908863
ENST00000449870ILF3chr1910782211+ENST00000344626SMARCA4chr1911134193+30567283172812831
ENST00000449870ILF3chr1910782211+ENST00000429416SMARCA4chr1911134193+32797283172812831
ENST00000449870ILF3chr1910782211+ENST00000541122SMARCA4chr1911134193+27237283172722802
ENST00000449870ILF3chr1910782211+ENST00000589677SMARCA4chr1911134193+27207283172719801
ENST00000449870ILF3chr1910782211+ENST00000444061SMARCA4chr1911134193+27117283172710798
ENST00000449870ILF3chr1910782211+ENST00000590574SMARCA4chr1911134193+27147283172713799
ENST00000449870ILF3chr1910782211+ENST00000413806SMARCA4chr1911134193+31897283172722801
ENST00000449870ILF3chr1910782211+ENST00000450717SMARCA4chr1911134193+31867283172719800
ENST00000318511ILF3chr1910782211+ENST00000358026SMARCA4chr1911134193+33757283172908863
ENST00000318511ILF3chr1910782211+ENST00000344626SMARCA4chr1911134193+30567283172812831
ENST00000318511ILF3chr1910782211+ENST00000429416SMARCA4chr1911134193+32797283172812831
ENST00000318511ILF3chr1910782211+ENST00000541122SMARCA4chr1911134193+27237283172722802
ENST00000318511ILF3chr1910782211+ENST00000589677SMARCA4chr1911134193+27207283172719801
ENST00000318511ILF3chr1910782211+ENST00000444061SMARCA4chr1911134193+27117283172710798
ENST00000318511ILF3chr1910782211+ENST00000590574SMARCA4chr1911134193+27147283172713799
ENST00000318511ILF3chr1910782211+ENST00000413806SMARCA4chr1911134193+31897283172722801
ENST00000318511ILF3chr1910782211+ENST00000450717SMARCA4chr1911134193+31867283172719800
ENST00000407004ILF3chr1910782211+ENST00000358026SMARCA4chr1911134193+33086612502841863
ENST00000407004ILF3chr1910782211+ENST00000344626SMARCA4chr1911134193+29896612502745831
ENST00000407004ILF3chr1910782211+ENST00000429416SMARCA4chr1911134193+32126612502745831
ENST00000407004ILF3chr1910782211+ENST00000541122SMARCA4chr1911134193+26566612502655802
ENST00000407004ILF3chr1910782211+ENST00000589677SMARCA4chr1911134193+26536612502652801
ENST00000407004ILF3chr1910782211+ENST00000444061SMARCA4chr1911134193+26446612502643798
ENST00000407004ILF3chr1910782211+ENST00000590574SMARCA4chr1911134193+26476612502646799
ENST00000407004ILF3chr1910782211+ENST00000413806SMARCA4chr1911134193+31226612502655801
ENST00000407004ILF3chr1910782211+ENST00000450717SMARCA4chr1911134193+31196612502652800
ENST00000589998ILF3chr1910782211+ENST00000358026SMARCA4chr1911134193+32756282172808863
ENST00000589998ILF3chr1910782211+ENST00000344626SMARCA4chr1911134193+29566282172712831
ENST00000589998ILF3chr1910782211+ENST00000429416SMARCA4chr1911134193+31796282172712831
ENST00000589998ILF3chr1910782211+ENST00000541122SMARCA4chr1911134193+26236282172622802
ENST00000589998ILF3chr1910782211+ENST00000589677SMARCA4chr1911134193+26206282172619801
ENST00000589998ILF3chr1910782211+ENST00000444061SMARCA4chr1911134193+26116282172610798
ENST00000589998ILF3chr1910782211+ENST00000590574SMARCA4chr1911134193+26146282172613799
ENST00000589998ILF3chr1910782211+ENST00000413806SMARCA4chr1911134193+30896282172622801
ENST00000589998ILF3chr1910782211+ENST00000450717SMARCA4chr1911134193+30866282172619800
ENST00000250241ILF3chr1910782211+ENST00000358026SMARCA4chr1911134193+3127480692660863
ENST00000250241ILF3chr1910782211+ENST00000344626SMARCA4chr1911134193+2808480692564831
ENST00000250241ILF3chr1910782211+ENST00000429416SMARCA4chr1911134193+3031480692564831
ENST00000250241ILF3chr1910782211+ENST00000541122SMARCA4chr1911134193+2475480692474801
ENST00000250241ILF3chr1910782211+ENST00000589677SMARCA4chr1911134193+2472480692471800
ENST00000250241ILF3chr1910782211+ENST00000444061SMARCA4chr1911134193+2463480692462797
ENST00000250241ILF3chr1910782211+ENST00000590574SMARCA4chr1911134193+2466480692465798
ENST00000250241ILF3chr1910782211+ENST00000413806SMARCA4chr1911134193+2941480692474801
ENST00000250241ILF3chr1910782211+ENST00000450717SMARCA4chr1911134193+2938480692471800
ENST00000592763ILF3chr1910782211+ENST00000358026SMARCA4chr1911134193+305841102591863
ENST00000592763ILF3chr1910782211+ENST00000344626SMARCA4chr1911134193+273941102495831
ENST00000592763ILF3chr1910782211+ENST00000429416SMARCA4chr1911134193+296241102495831
ENST00000592763ILF3chr1910782211+ENST00000541122SMARCA4chr1911134193+240641102405801
ENST00000592763ILF3chr1910782211+ENST00000589677SMARCA4chr1911134193+240341102402800
ENST00000592763ILF3chr1910782211+ENST00000444061SMARCA4chr1911134193+239441102393797
ENST00000592763ILF3chr1910782211+ENST00000590574SMARCA4chr1911134193+239741102396798
ENST00000592763ILF3chr1910782211+ENST00000413806SMARCA4chr1911134193+287241102405801
ENST00000592763ILF3chr1910782211+ENST00000450717SMARCA4chr1911134193+286941102402800
ENST00000588657ILF3chr1910782211+ENST00000358026SMARCA4chr1911134193+305841102591863
ENST00000588657ILF3chr1910782211+ENST00000344626SMARCA4chr1911134193+273941102495831
ENST00000588657ILF3chr1910782211+ENST00000429416SMARCA4chr1911134193+296241102495831
ENST00000588657ILF3chr1910782211+ENST00000541122SMARCA4chr1911134193+240641102405801
ENST00000588657ILF3chr1910782211+ENST00000589677SMARCA4chr1911134193+240341102402800
ENST00000588657ILF3chr1910782211+ENST00000444061SMARCA4chr1911134193+239441102393797
ENST00000588657ILF3chr1910782211+ENST00000590574SMARCA4chr1911134193+239741102396798
ENST00000588657ILF3chr1910782211+ENST00000413806SMARCA4chr1911134193+287241102405801
ENST00000588657ILF3chr1910782211+ENST00000450717SMARCA4chr1911134193+286941102402800
ENST00000590261ILF3chr1910782211+ENST00000358026SMARCA4chr1911134193+305841102591863
ENST00000590261ILF3chr1910782211+ENST00000344626SMARCA4chr1911134193+273941102495831
ENST00000590261ILF3chr1910782211+ENST00000429416SMARCA4chr1911134193+296241102495831
ENST00000590261ILF3chr1910782211+ENST00000541122SMARCA4chr1911134193+240641102405801
ENST00000590261ILF3chr1910782211+ENST00000589677SMARCA4chr1911134193+240341102402800
ENST00000590261ILF3chr1910782211+ENST00000444061SMARCA4chr1911134193+239441102393797
ENST00000590261ILF3chr1910782211+ENST00000590574SMARCA4chr1911134193+239741102396798
ENST00000590261ILF3chr1910782211+ENST00000413806SMARCA4chr1911134193+287241102405801
ENST00000590261ILF3chr1910782211+ENST00000450717SMARCA4chr1911134193+286941102402800

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000420083ENST00000358026ILF3chr1910782211+SMARCA4chr1911134194+0.0145711960.98542887
ENST00000420083ENST00000344626ILF3chr1910782211+SMARCA4chr1911134194+0.0186927970.98130715
ENST00000420083ENST00000429416ILF3chr1910782211+SMARCA4chr1911134194+0.0153946220.9846053
ENST00000420083ENST00000541122ILF3chr1910782211+SMARCA4chr1911134194+0.0193117780.9806882
ENST00000420083ENST00000589677ILF3chr1910782211+SMARCA4chr1911134194+0.0193192750.98068076
ENST00000420083ENST00000444061ILF3chr1910782211+SMARCA4chr1911134194+0.0189239350.981076
ENST00000420083ENST00000590574ILF3chr1910782211+SMARCA4chr1911134194+0.018946360.98105365
ENST00000420083ENST00000413806ILF3chr1910782211+SMARCA4chr1911134194+0.0155900550.9844099
ENST00000420083ENST00000450717ILF3chr1910782211+SMARCA4chr1911134194+0.0155199670.9844801
ENST00000449870ENST00000358026ILF3chr1910782211+SMARCA4chr1911134194+0.0145711960.98542887
ENST00000449870ENST00000344626ILF3chr1910782211+SMARCA4chr1911134194+0.0186927970.98130715
ENST00000449870ENST00000429416ILF3chr1910782211+SMARCA4chr1911134194+0.0153946220.9846053
ENST00000449870ENST00000541122ILF3chr1910782211+SMARCA4chr1911134194+0.0193117780.9806882
ENST00000449870ENST00000589677ILF3chr1910782211+SMARCA4chr1911134194+0.0193192750.98068076
ENST00000449870ENST00000444061ILF3chr1910782211+SMARCA4chr1911134194+0.0189239350.981076
ENST00000449870ENST00000590574ILF3chr1910782211+SMARCA4chr1911134194+0.018946360.98105365
ENST00000449870ENST00000413806ILF3chr1910782211+SMARCA4chr1911134194+0.0155900550.9844099
ENST00000449870ENST00000450717ILF3chr1910782211+SMARCA4chr1911134194+0.0155199670.9844801
ENST00000318511ENST00000358026ILF3chr1910782211+SMARCA4chr1911134194+0.0145711960.98542887
ENST00000318511ENST00000344626ILF3chr1910782211+SMARCA4chr1911134194+0.0186927970.98130715
ENST00000318511ENST00000429416ILF3chr1910782211+SMARCA4chr1911134194+0.0153946220.9846053
ENST00000318511ENST00000541122ILF3chr1910782211+SMARCA4chr1911134194+0.0193117780.9806882
ENST00000318511ENST00000589677ILF3chr1910782211+SMARCA4chr1911134194+0.0193192750.98068076
ENST00000318511ENST00000444061ILF3chr1910782211+SMARCA4chr1911134194+0.0189239350.981076
ENST00000318511ENST00000590574ILF3chr1910782211+SMARCA4chr1911134194+0.018946360.98105365
ENST00000318511ENST00000413806ILF3chr1910782211+SMARCA4chr1911134194+0.0155900550.9844099
ENST00000318511ENST00000450717ILF3chr1910782211+SMARCA4chr1911134194+0.0155199670.9844801
ENST00000407004ENST00000358026ILF3chr1910782211+SMARCA4chr1911134194+0.0156582460.9843418
ENST00000407004ENST00000344626ILF3chr1910782211+SMARCA4chr1911134194+0.018634010.98136604
ENST00000407004ENST00000429416ILF3chr1910782211+SMARCA4chr1911134194+0.0156773350.9843226
ENST00000407004ENST00000541122ILF3chr1910782211+SMARCA4chr1911134194+0.0191278140.98087215
ENST00000407004ENST00000589677ILF3chr1910782211+SMARCA4chr1911134194+0.0192241430.98077583
ENST00000407004ENST00000444061ILF3chr1910782211+SMARCA4chr1911134194+0.0187344640.9812655
ENST00000407004ENST00000590574ILF3chr1910782211+SMARCA4chr1911134194+0.0186632550.9813368
ENST00000407004ENST00000413806ILF3chr1910782211+SMARCA4chr1911134194+0.0156612080.98433876
ENST00000407004ENST00000450717ILF3chr1910782211+SMARCA4chr1911134194+0.0156012110.9843987
ENST00000589998ENST00000358026ILF3chr1910782211+SMARCA4chr1911134194+0.0154203880.98457956
ENST00000589998ENST00000344626ILF3chr1910782211+SMARCA4chr1911134194+0.018923590.98107636
ENST00000589998ENST00000429416ILF3chr1910782211+SMARCA4chr1911134194+0.0156932680.9843067
ENST00000589998ENST00000541122ILF3chr1910782211+SMARCA4chr1911134194+0.019576390.98042357
ENST00000589998ENST00000589677ILF3chr1910782211+SMARCA4chr1911134194+0.019537120.98046285
ENST00000589998ENST00000444061ILF3chr1910782211+SMARCA4chr1911134194+0.019151380.98084867
ENST00000589998ENST00000590574ILF3chr1910782211+SMARCA4chr1911134194+0.0191807110.9808193
ENST00000589998ENST00000413806ILF3chr1910782211+SMARCA4chr1911134194+0.0156792940.98432064
ENST00000589998ENST00000450717ILF3chr1910782211+SMARCA4chr1911134194+0.0156221930.9843778
ENST00000250241ENST00000358026ILF3chr1910782211+SMARCA4chr1911134194+0.0155420730.9844579
ENST00000250241ENST00000344626ILF3chr1910782211+SMARCA4chr1911134194+0.0192871930.9807128
ENST00000250241ENST00000429416ILF3chr1910782211+SMARCA4chr1911134194+0.0159307120.9840693
ENST00000250241ENST00000541122ILF3chr1910782211+SMARCA4chr1911134194+0.0199032240.98009676
ENST00000250241ENST00000589677ILF3chr1910782211+SMARCA4chr1911134194+0.0198532530.9801467
ENST00000250241ENST00000444061ILF3chr1910782211+SMARCA4chr1911134194+0.0195330080.980467
ENST00000250241ENST00000590574ILF3chr1910782211+SMARCA4chr1911134194+0.0195937860.9804063
ENST00000250241ENST00000413806ILF3chr1910782211+SMARCA4chr1911134194+0.0157711950.98422885
ENST00000250241ENST00000450717ILF3chr1910782211+SMARCA4chr1911134194+0.0157025880.98429745
ENST00000592763ENST00000358026ILF3chr1910782211+SMARCA4chr1911134194+0.0160091760.9839908
ENST00000592763ENST00000344626ILF3chr1910782211+SMARCA4chr1911134194+0.0195037350.9804962
ENST00000592763ENST00000429416ILF3chr1910782211+SMARCA4chr1911134194+0.0160209220.9839791
ENST00000592763ENST00000541122ILF3chr1910782211+SMARCA4chr1911134194+0.0202270780.9797729
ENST00000592763ENST00000589677ILF3chr1910782211+SMARCA4chr1911134194+0.020178180.9798218
ENST00000592763ENST00000444061ILF3chr1910782211+SMARCA4chr1911134194+0.019761380.9802387
ENST00000592763ENST00000590574ILF3chr1910782211+SMARCA4chr1911134194+0.0197876560.98021233
ENST00000592763ENST00000413806ILF3chr1910782211+SMARCA4chr1911134194+0.0159088260.9840912
ENST00000592763ENST00000450717ILF3chr1910782211+SMARCA4chr1911134194+0.0158327840.98416716
ENST00000588657ENST00000358026ILF3chr1910782211+SMARCA4chr1911134194+0.0160091760.9839908
ENST00000588657ENST00000344626ILF3chr1910782211+SMARCA4chr1911134194+0.0195037350.9804962
ENST00000588657ENST00000429416ILF3chr1910782211+SMARCA4chr1911134194+0.0160209220.9839791
ENST00000588657ENST00000541122ILF3chr1910782211+SMARCA4chr1911134194+0.0202270780.9797729
ENST00000588657ENST00000589677ILF3chr1910782211+SMARCA4chr1911134194+0.020178180.9798218
ENST00000588657ENST00000444061ILF3chr1910782211+SMARCA4chr1911134194+0.019761380.9802387
ENST00000588657ENST00000590574ILF3chr1910782211+SMARCA4chr1911134194+0.0197876560.98021233
ENST00000588657ENST00000413806ILF3chr1910782211+SMARCA4chr1911134194+0.0159088260.9840912
ENST00000588657ENST00000450717ILF3chr1910782211+SMARCA4chr1911134194+0.0158327840.98416716
ENST00000590261ENST00000358026ILF3chr1910782211+SMARCA4chr1911134194+0.0160091760.9839908
ENST00000590261ENST00000344626ILF3chr1910782211+SMARCA4chr1911134194+0.0195037350.9804962
ENST00000590261ENST00000429416ILF3chr1910782211+SMARCA4chr1911134194+0.0160209220.9839791
ENST00000590261ENST00000541122ILF3chr1910782211+SMARCA4chr1911134194+0.0202270780.9797729
ENST00000590261ENST00000589677ILF3chr1910782211+SMARCA4chr1911134194+0.020178180.9798218
ENST00000590261ENST00000444061ILF3chr1910782211+SMARCA4chr1911134194+0.019761380.9802387
ENST00000590261ENST00000590574ILF3chr1910782211+SMARCA4chr1911134194+0.0197876560.98021233
ENST00000590261ENST00000413806ILF3chr1910782211+SMARCA4chr1911134194+0.0159088260.9840912
ENST00000590261ENST00000450717ILF3chr1910782211+SMARCA4chr1911134194+0.0158327840.98416716
ENST00000420083ENST00000358026ILF3chr1910782211+SMARCA4chr1911134193+0.0145711960.98542887
ENST00000420083ENST00000344626ILF3chr1910782211+SMARCA4chr1911134193+0.0186927970.98130715
ENST00000420083ENST00000429416ILF3chr1910782211+SMARCA4chr1911134193+0.0153946220.9846053
ENST00000420083ENST00000541122ILF3chr1910782211+SMARCA4chr1911134193+0.0193117780.9806882
ENST00000420083ENST00000589677ILF3chr1910782211+SMARCA4chr1911134193+0.0193192750.98068076
ENST00000420083ENST00000444061ILF3chr1910782211+SMARCA4chr1911134193+0.0189239350.981076
ENST00000420083ENST00000590574ILF3chr1910782211+SMARCA4chr1911134193+0.018946360.98105365
ENST00000420083ENST00000413806ILF3chr1910782211+SMARCA4chr1911134193+0.0155900550.9844099
ENST00000420083ENST00000450717ILF3chr1910782211+SMARCA4chr1911134193+0.0155199670.9844801
ENST00000449870ENST00000358026ILF3chr1910782211+SMARCA4chr1911134193+0.0145711960.98542887
ENST00000449870ENST00000344626ILF3chr1910782211+SMARCA4chr1911134193+0.0186927970.98130715
ENST00000449870ENST00000429416ILF3chr1910782211+SMARCA4chr1911134193+0.0153946220.9846053
ENST00000449870ENST00000541122ILF3chr1910782211+SMARCA4chr1911134193+0.0193117780.9806882
ENST00000449870ENST00000589677ILF3chr1910782211+SMARCA4chr1911134193+0.0193192750.98068076
ENST00000449870ENST00000444061ILF3chr1910782211+SMARCA4chr1911134193+0.0189239350.981076
ENST00000449870ENST00000590574ILF3chr1910782211+SMARCA4chr1911134193+0.018946360.98105365
ENST00000449870ENST00000413806ILF3chr1910782211+SMARCA4chr1911134193+0.0155900550.9844099
ENST00000449870ENST00000450717ILF3chr1910782211+SMARCA4chr1911134193+0.0155199670.9844801
ENST00000318511ENST00000358026ILF3chr1910782211+SMARCA4chr1911134193+0.0145711960.98542887
ENST00000318511ENST00000344626ILF3chr1910782211+SMARCA4chr1911134193+0.0186927970.98130715
ENST00000318511ENST00000429416ILF3chr1910782211+SMARCA4chr1911134193+0.0153946220.9846053
ENST00000318511ENST00000541122ILF3chr1910782211+SMARCA4chr1911134193+0.0193117780.9806882
ENST00000318511ENST00000589677ILF3chr1910782211+SMARCA4chr1911134193+0.0193192750.98068076
ENST00000318511ENST00000444061ILF3chr1910782211+SMARCA4chr1911134193+0.0189239350.981076
ENST00000318511ENST00000590574ILF3chr1910782211+SMARCA4chr1911134193+0.018946360.98105365
ENST00000318511ENST00000413806ILF3chr1910782211+SMARCA4chr1911134193+0.0155900550.9844099
ENST00000318511ENST00000450717ILF3chr1910782211+SMARCA4chr1911134193+0.0155199670.9844801
ENST00000407004ENST00000358026ILF3chr1910782211+SMARCA4chr1911134193+0.0156582460.9843418
ENST00000407004ENST00000344626ILF3chr1910782211+SMARCA4chr1911134193+0.018634010.98136604
ENST00000407004ENST00000429416ILF3chr1910782211+SMARCA4chr1911134193+0.0156773350.9843226
ENST00000407004ENST00000541122ILF3chr1910782211+SMARCA4chr1911134193+0.0191278140.98087215
ENST00000407004ENST00000589677ILF3chr1910782211+SMARCA4chr1911134193+0.0192241430.98077583
ENST00000407004ENST00000444061ILF3chr1910782211+SMARCA4chr1911134193+0.0187344640.9812655
ENST00000407004ENST00000590574ILF3chr1910782211+SMARCA4chr1911134193+0.0186632550.9813368
ENST00000407004ENST00000413806ILF3chr1910782211+SMARCA4chr1911134193+0.0156612080.98433876
ENST00000407004ENST00000450717ILF3chr1910782211+SMARCA4chr1911134193+0.0156012110.9843987
ENST00000589998ENST00000358026ILF3chr1910782211+SMARCA4chr1911134193+0.0154203880.98457956
ENST00000589998ENST00000344626ILF3chr1910782211+SMARCA4chr1911134193+0.018923590.98107636
ENST00000589998ENST00000429416ILF3chr1910782211+SMARCA4chr1911134193+0.0156932680.9843067
ENST00000589998ENST00000541122ILF3chr1910782211+SMARCA4chr1911134193+0.019576390.98042357
ENST00000589998ENST00000589677ILF3chr1910782211+SMARCA4chr1911134193+0.019537120.98046285
ENST00000589998ENST00000444061ILF3chr1910782211+SMARCA4chr1911134193+0.019151380.98084867
ENST00000589998ENST00000590574ILF3chr1910782211+SMARCA4chr1911134193+0.0191807110.9808193
ENST00000589998ENST00000413806ILF3chr1910782211+SMARCA4chr1911134193+0.0156792940.98432064
ENST00000589998ENST00000450717ILF3chr1910782211+SMARCA4chr1911134193+0.0156221930.9843778
ENST00000250241ENST00000358026ILF3chr1910782211+SMARCA4chr1911134193+0.0155420730.9844579
ENST00000250241ENST00000344626ILF3chr1910782211+SMARCA4chr1911134193+0.0192871930.9807128
ENST00000250241ENST00000429416ILF3chr1910782211+SMARCA4chr1911134193+0.0159307120.9840693
ENST00000250241ENST00000541122ILF3chr1910782211+SMARCA4chr1911134193+0.0199032240.98009676
ENST00000250241ENST00000589677ILF3chr1910782211+SMARCA4chr1911134193+0.0198532530.9801467
ENST00000250241ENST00000444061ILF3chr1910782211+SMARCA4chr1911134193+0.0195330080.980467
ENST00000250241ENST00000590574ILF3chr1910782211+SMARCA4chr1911134193+0.0195937860.9804063
ENST00000250241ENST00000413806ILF3chr1910782211+SMARCA4chr1911134193+0.0157711950.98422885
ENST00000250241ENST00000450717ILF3chr1910782211+SMARCA4chr1911134193+0.0157025880.98429745
ENST00000592763ENST00000358026ILF3chr1910782211+SMARCA4chr1911134193+0.0160091760.9839908
ENST00000592763ENST00000344626ILF3chr1910782211+SMARCA4chr1911134193+0.0195037350.9804962
ENST00000592763ENST00000429416ILF3chr1910782211+SMARCA4chr1911134193+0.0160209220.9839791
ENST00000592763ENST00000541122ILF3chr1910782211+SMARCA4chr1911134193+0.0202270780.9797729
ENST00000592763ENST00000589677ILF3chr1910782211+SMARCA4chr1911134193+0.020178180.9798218
ENST00000592763ENST00000444061ILF3chr1910782211+SMARCA4chr1911134193+0.019761380.9802387
ENST00000592763ENST00000590574ILF3chr1910782211+SMARCA4chr1911134193+0.0197876560.98021233
ENST00000592763ENST00000413806ILF3chr1910782211+SMARCA4chr1911134193+0.0159088260.9840912
ENST00000592763ENST00000450717ILF3chr1910782211+SMARCA4chr1911134193+0.0158327840.98416716
ENST00000588657ENST00000358026ILF3chr1910782211+SMARCA4chr1911134193+0.0160091760.9839908
ENST00000588657ENST00000344626ILF3chr1910782211+SMARCA4chr1911134193+0.0195037350.9804962
ENST00000588657ENST00000429416ILF3chr1910782211+SMARCA4chr1911134193+0.0160209220.9839791
ENST00000588657ENST00000541122ILF3chr1910782211+SMARCA4chr1911134193+0.0202270780.9797729
ENST00000588657ENST00000589677ILF3chr1910782211+SMARCA4chr1911134193+0.020178180.9798218
ENST00000588657ENST00000444061ILF3chr1910782211+SMARCA4chr1911134193+0.019761380.9802387
ENST00000588657ENST00000590574ILF3chr1910782211+SMARCA4chr1911134193+0.0197876560.98021233
ENST00000588657ENST00000413806ILF3chr1910782211+SMARCA4chr1911134193+0.0159088260.9840912
ENST00000588657ENST00000450717ILF3chr1910782211+SMARCA4chr1911134193+0.0158327840.98416716
ENST00000590261ENST00000358026ILF3chr1910782211+SMARCA4chr1911134193+0.0160091760.9839908
ENST00000590261ENST00000344626ILF3chr1910782211+SMARCA4chr1911134193+0.0195037350.9804962
ENST00000590261ENST00000429416ILF3chr1910782211+SMARCA4chr1911134193+0.0160209220.9839791
ENST00000590261ENST00000541122ILF3chr1910782211+SMARCA4chr1911134193+0.0202270780.9797729
ENST00000590261ENST00000589677ILF3chr1910782211+SMARCA4chr1911134193+0.020178180.9798218
ENST00000590261ENST00000444061ILF3chr1910782211+SMARCA4chr1911134193+0.019761380.9802387
ENST00000590261ENST00000590574ILF3chr1910782211+SMARCA4chr1911134193+0.0197876560.98021233
ENST00000590261ENST00000413806ILF3chr1910782211+SMARCA4chr1911134193+0.0159088260.9840912
ENST00000590261ENST00000450717ILF3chr1910782211+SMARCA4chr1911134193+0.0158327840.98416716

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for ILF3-SMARCA4

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide

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Potential FusionNeoAntigen Information of ILF3-SMARCA4 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Potential FusionNeoAntigen Information of ILF3-SMARCA4 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of ILF3-SMARCA4

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ILF3-SMARCA4

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score

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Vaccine Design for the FusionNeoAntigens of ILF3-SMARCA4

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of ILF3-SMARCA4

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample

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Potential target of CAR-T therapy development for ILF3-SMARCA4

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to ILF3-SMARCA4

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ILF3-SMARCA4

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource