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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:KAT6B-KANSL1

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KAT6B-KANSL1
FusionPDB ID: 41232
FusionGDB2.0 ID: 41234
HgeneTgene
Gene symbol

KAT6B

KANSL1

Gene ID

23522

284058

Gene namelysine acetyltransferase 6BKAT8 regulatory NSL complex subunit 1
SynonymsGTPTS|MORF|MOZ2|MYST4|ZC2HC6B|qkf|querkopfCENP-36|KDVS|KIAA1267|MSL1v1|NSL1|hMSL1v1
Cytomap

10q22.2

17q21.31

Type of geneprotein-codingprotein-coding
Descriptionhistone acetyltransferase KAT6BK(lysine) acetyltransferase 6BMOZ, YBF2/SAS3, SAS2 and TIP60 protein 4MOZ-related factorMYST histone acetyltransferase (monocytic leukemia) 4MYST-4histone acetyltransferase MORFhistone acetyltransferase MOZ2histone aKAT8 regulatory NSL complex subunit 1MLL1/MLL complex subunit KANSL1MSL1 homolog 1NSL complex protein NSL1centromere protein 36male-specific lethal 1 homolognon-specific lethal 1 homolog
Modification date2020031320200327
UniProtAcc

Q8WYB5

Main function of 5'-partner protein: FUNCTION: Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:16387653}.

A0AUZ9

Main function of 5'-partner protein:
Ensembl transtripts involved in fusion geneENST idsENST00000287239, ENST00000372711, 
ENST00000372714, ENST00000372724, 
ENST00000372725, ENST00000490365, 
ENST00000576248, ENST00000262419, 
ENST00000393476, ENST00000432791, 
ENST00000572904, ENST00000574590, 
ENST00000575318, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 21 X 10=483017 X 18 X 11=3366
# samples 3228
** MAII scorelog2(32/4830*10)=-3.91587937883577
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/3366*10)=-3.58753644438498
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: KAT6B [Title/Abstract] AND KANSL1 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: KAT6B [Title/Abstract] AND KANSL1 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KAT6B(76603236)-KANSL1(44111651), # samples:1
Anticipated loss of major functional domain due to fusion event.KAT6B-KANSL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6B-KANSL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6B-KANSL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6B-KANSL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKAT6B

GO:0016573

histone acetylation

11965546

HgeneKAT6B

GO:0043966

histone H3 acetylation

16387653

HgeneKAT6B

GO:0045892

negative regulation of transcription, DNA-templated

10497217

HgeneKAT6B

GO:0045893

positive regulation of transcription, DNA-templated

10497217|11965546

TgeneKANSL1

GO:0043981

histone H4-K5 acetylation

20018852

TgeneKANSL1

GO:0043982

histone H4-K8 acetylation

20018852

TgeneKANSL1

GO:0043984

histone H4-K16 acetylation

20018852



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:76603236/chr17:44111651)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across KAT6B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KANSL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000372725KAT6Bchr1076603236+ENST00000574590KANSL1chr1744111651-33099723421748468
ENST00000372725KAT6Bchr1076603236+ENST00000575318KANSL1chr1744111651-32979723421745467
ENST00000372725KAT6Bchr1076603236+ENST00000572904KANSL1chr1744111651-32729723421748468
ENST00000372725KAT6Bchr1076603236+ENST00000262419KANSL1chr1744111651-32699723421748468
ENST00000372725KAT6Bchr1076603236+ENST00000432791KANSL1chr1744111651-32579723421748468
ENST00000372725KAT6Bchr1076603236+ENST00000393476KANSL1chr1744111651-32579723421748468
ENST00000372724KAT6Bchr1076603236+ENST00000574590KANSL1chr1744111651-347211355051911468
ENST00000372724KAT6Bchr1076603236+ENST00000575318KANSL1chr1744111651-346011355051908467
ENST00000372724KAT6Bchr1076603236+ENST00000572904KANSL1chr1744111651-343511355051911468
ENST00000372724KAT6Bchr1076603236+ENST00000262419KANSL1chr1744111651-343211355051911468
ENST00000372724KAT6Bchr1076603236+ENST00000432791KANSL1chr1744111651-342011355051911468
ENST00000372724KAT6Bchr1076603236+ENST00000393476KANSL1chr1744111651-342011355051911468
ENST00000287239KAT6Bchr1076603236+ENST00000574590KANSL1chr1744111651-344711104801886468
ENST00000287239KAT6Bchr1076603236+ENST00000575318KANSL1chr1744111651-343511104801883467
ENST00000287239KAT6Bchr1076603236+ENST00000572904KANSL1chr1744111651-341011104801886468
ENST00000287239KAT6Bchr1076603236+ENST00000262419KANSL1chr1744111651-340711104801886468
ENST00000287239KAT6Bchr1076603236+ENST00000432791KANSL1chr1744111651-339511104801886468
ENST00000287239KAT6Bchr1076603236+ENST00000393476KANSL1chr1744111651-339511104801886468
ENST00000372714KAT6Bchr1076603236+ENST00000574590KANSL1chr1744111651-336010233931799468
ENST00000372714KAT6Bchr1076603236+ENST00000575318KANSL1chr1744111651-334810233931796467
ENST00000372714KAT6Bchr1076603236+ENST00000572904KANSL1chr1744111651-332310233931799468
ENST00000372714KAT6Bchr1076603236+ENST00000262419KANSL1chr1744111651-332010233931799468
ENST00000372714KAT6Bchr1076603236+ENST00000432791KANSL1chr1744111651-330810233931799468
ENST00000372714KAT6Bchr1076603236+ENST00000393476KANSL1chr1744111651-330810233931799468
ENST00000372711KAT6Bchr1076603236+ENST00000574590KANSL1chr1744111651-32699323021708468
ENST00000372711KAT6Bchr1076603236+ENST00000575318KANSL1chr1744111651-32579323021705467
ENST00000372711KAT6Bchr1076603236+ENST00000572904KANSL1chr1744111651-32329323021708468
ENST00000372711KAT6Bchr1076603236+ENST00000262419KANSL1chr1744111651-32299323021708468
ENST00000372711KAT6Bchr1076603236+ENST00000432791KANSL1chr1744111651-32179323021708468
ENST00000372711KAT6Bchr1076603236+ENST00000393476KANSL1chr1744111651-32179323021708468

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372725ENST00000574590KAT6Bchr1076603236+KANSL1chr1744111651-0.0017028470.99829715
ENST00000372725ENST00000575318KAT6Bchr1076603236+KANSL1chr1744111651-0.001970.99803
ENST00000372725ENST00000572904KAT6Bchr1076603236+KANSL1chr1744111651-0.0019839560.998016
ENST00000372725ENST00000262419KAT6Bchr1076603236+KANSL1chr1744111651-0.0019862790.99801373
ENST00000372725ENST00000432791KAT6Bchr1076603236+KANSL1chr1744111651-0.0022693620.9977307
ENST00000372725ENST00000393476KAT6Bchr1076603236+KANSL1chr1744111651-0.0022693620.9977307
ENST00000372724ENST00000574590KAT6Bchr1076603236+KANSL1chr1744111651-0.001810730.9981893
ENST00000372724ENST00000575318KAT6Bchr1076603236+KANSL1chr1744111651-0.002098430.99790156
ENST00000372724ENST00000572904KAT6Bchr1076603236+KANSL1chr1744111651-0.0021665730.99783343
ENST00000372724ENST00000262419KAT6Bchr1076603236+KANSL1chr1744111651-0.0021768650.9978231
ENST00000372724ENST00000432791KAT6Bchr1076603236+KANSL1chr1744111651-0.002444940.9975551
ENST00000372724ENST00000393476KAT6Bchr1076603236+KANSL1chr1744111651-0.002444940.9975551
ENST00000287239ENST00000574590KAT6Bchr1076603236+KANSL1chr1744111651-0.0018584050.99814165
ENST00000287239ENST00000575318KAT6Bchr1076603236+KANSL1chr1744111651-0.0021459420.99785405
ENST00000287239ENST00000572904KAT6Bchr1076603236+KANSL1chr1744111651-0.0021952410.9978047
ENST00000287239ENST00000262419KAT6Bchr1076603236+KANSL1chr1744111651-0.0022067180.9977933
ENST00000287239ENST00000432791KAT6Bchr1076603236+KANSL1chr1744111651-0.0024730470.99752694
ENST00000287239ENST00000393476KAT6Bchr1076603236+KANSL1chr1744111651-0.0024730470.99752694
ENST00000372714ENST00000574590KAT6Bchr1076603236+KANSL1chr1744111651-0.0019035170.9980965
ENST00000372714ENST00000575318KAT6Bchr1076603236+KANSL1chr1744111651-0.0022003730.9977996
ENST00000372714ENST00000572904KAT6Bchr1076603236+KANSL1chr1744111651-0.0022469860.99775296
ENST00000372714ENST00000262419KAT6Bchr1076603236+KANSL1chr1744111651-0.0022587660.9977412
ENST00000372714ENST00000432791KAT6Bchr1076603236+KANSL1chr1744111651-0.0025476360.9974523
ENST00000372714ENST00000393476KAT6Bchr1076603236+KANSL1chr1744111651-0.0025476360.9974523
ENST00000372711ENST00000574590KAT6Bchr1076603236+KANSL1chr1744111651-0.0012423920.9987576
ENST00000372711ENST00000575318KAT6Bchr1076603236+KANSL1chr1744111651-0.0014571080.9985429
ENST00000372711ENST00000572904KAT6Bchr1076603236+KANSL1chr1744111651-0.0014144850.9985856
ENST00000372711ENST00000262419KAT6Bchr1076603236+KANSL1chr1744111651-0.0014175230.9985825
ENST00000372711ENST00000432791KAT6Bchr1076603236+KANSL1chr1744111651-0.0015754450.99842453
ENST00000372711ENST00000393476KAT6Bchr1076603236+KANSL1chr1744111651-0.0015754450.99842453

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for KAT6B-KANSL1

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
KAT6Bchr1076603236KANSL1chr17441116511023209SLPPVSLLPHEKDQQPVRRRRGESSF
KAT6Bchr1076603236KANSL1chr17441116511023209SLPPVSLLPHEKDQQQPVRRRRGESS
KAT6Bchr1076603236KANSL1chr17441116511110209SLPPVSLLPHEKDQQPVRRRRGESSF
KAT6Bchr1076603236KANSL1chr17441116511110209SLPPVSLLPHEKDQQQPVRRRRGESS
KAT6Bchr1076603236KANSL1chr17441116511135209SLPPVSLLPHEKDQQPVRRRRGESSF
KAT6Bchr1076603236KANSL1chr17441116511135209SLPPVSLLPHEKDQQQPVRRRRGESS
KAT6Bchr1076603236KANSL1chr1744111651932209SLPPVSLLPHEKDQQPVRRRRGESSF
KAT6Bchr1076603236KANSL1chr1744111651932209SLPPVSLLPHEKDQQQPVRRRRGESS
KAT6Bchr1076603236KANSL1chr1744111651972209SLPPVSLLPHEKDQQPVRRRRGESSF
KAT6Bchr1076603236KANSL1chr1744111651972209SLPPVSLLPHEKDQQQPVRRRRGESS

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Potential FusionNeoAntigen Information of KAT6B-KANSL1 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
KAT6B-KANSL1_76603236_44111651.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B50:02HEKDQQQPV0.99550.7697918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B45:01HEKDQQQPV0.99210.8795918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B40:01HEKDQQQPV0.99030.6889918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B41:01HEKDQQQPV0.94030.7994918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B40:05HEKDQQQPV0.8640.573918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B44:05HEKDQQQPV0.8290.5474918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B50:01HEKDQQQPV0.81240.9363918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B18:01HEKDQQQPV0.70860.738918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B39:13HEKDQQQPV0.57730.8371918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B08:09LPHEKDQQPV0.9260.8562717
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B51:02LPHEKDQQPV0.92580.8764717
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B40:06HEKDQQQPV0.99920.8907918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B44:09HEKDQQQPV0.77880.5375918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B39:08HEKDQQQPV0.71720.7571918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B78:01LPHEKDQQPV0.90830.915717
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B51:08LPHEKDQQPV0.80070.639717
KAT6B-KANSL1chr1076603236chr17441116511110HLA-A31:01KDQQQPVRRR0.61660.77051121
KAT6B-KANSL1chr1076603236chr17441116511110HLA-A31:01KDQQPVRRRR0.59420.71871121
KAT6B-KANSL1chr1076603236chr17441116511110HLA-A31:01KDQQQPVRRRR0.95490.81541122
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B40:40HEKDQQQPV0.99910.5215918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B40:04HEKDQQQPV0.9960.8299918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B40:36HEKDQQQPV0.99020.7486918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B40:49HEKDQQQPV0.98910.7918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B41:03HEKDQQQPV0.95830.6057918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B50:05HEKDQQQPV0.81240.9363918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B50:04HEKDQQQPV0.81240.9363918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B18:05HEKDQQQPV0.70860.738918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B18:06HEKDQQPVR0.70510.84918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B18:03HEKDQQQPV0.69110.7168918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B18:06HEKDQQQPV0.65410.7729918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B18:11HEKDQQQPV0.64720.599918
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B59:01LPHEKDQQPV0.94830.895717
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B56:05LPHEKDQQPV0.90240.8384717
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B51:13LPHEKDQQPV0.82910.7536717
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B51:29LPHEKDQQPV0.80470.6708717
KAT6B-KANSL1chr1076603236chr17441116511110HLA-B51:05LPHEKDQQPV0.7180.6012717

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Potential FusionNeoAntigen Information of KAT6B-KANSL1 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
KAT6B-KANSL1_76603236_44111651.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-0806LPPVSLLPHEKDQQQ116
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-0806LPPVSLLPHEKDQQP116
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-0810LPPVSLLPHEKDQQQ116
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-0810LPPVSLLPHEKDQQP116
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-0822LPPVSLLPHEKDQQQ116
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-0822LPPVSLLPHEKDQQP116
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1103PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1141PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1148PVSLLPHEKDQQQPV318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1148PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1159PVSLLPHEKDQQQPV318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1159PPVSLLPHEKDQQQP217
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1159PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1163PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1176PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1185PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1304PVSLLPHEKDQQQPV318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1304PPVSLLPHEKDQQQP217
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1304PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1308PVSLLPHEKDQQQPV318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1308PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1309PVSLLPHEKDQQQPV318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1309PPVSLLPHEKDQQQP217
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1309PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1324PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1327PVSLLPHEKDQQQPV318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1327PPVSLLPHEKDQQQP217
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1327PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1332PPVSLLPHEKDQQQP217
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1332PVSLLPHEKDQQQPV318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1332PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1348PPVSLLPHEKDQQQP217
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1348PVSLLPHEKDQQQPV318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1348PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1358LPPVSLLPHEKDQQQ116
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1358LPPVSLLPHEKDQQP116
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1370PVSLLPHEKDQQQPV318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1370PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1371PVSLLPHEKDQQQPV318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1371PPVSLLPHEKDQQQP217
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1371PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1372PVSLLPHEKDQQQPV318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1372PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1375PPVSLLPHEKDQQQP217
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1375PVSLLPHEKDQQQPV318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1375PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1375PPVSLLPHEKDQQPV217
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1376PVSLLPHEKDQQQPV318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1376PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1381LPPVSLLPHEKDQQQ116
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1381LPPVSLLPHEKDQQP116
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1384PVSLLPHEKDQQQPV318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1384PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1389LPPVSLLPHEKDQQQ116
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1389LPPVSLLPHEKDQQP116
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1393PVSLLPHEKDQQQPV318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1393PPVSLLPHEKDQQQP217
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1393PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1437PVSLLPHEKDQQQPV318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1437PPVSLLPHEKDQQQP217
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1437PVSLLPHEKDQQPVR318
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1478LPPVSLLPHEKDQQQ116
KAT6B-KANSL1chr1076603236chr17441116511110DRB1-1478LPPVSLLPHEKDQQP116

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Fusion breakpoint peptide structures of KAT6B-KANSL1

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
5253LLPHEKDQQPVRRRKAT6BKANSL1chr1076603236chr17441116511110
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
5254LLPHEKDQQQPVRRKAT6BKANSL1chr1076603236chr17441116511110

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of KAT6B-KANSL1

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN5253LLPHEKDQQPVRRR-6.36359-6.55369
HLA-B14:023BVN5253LLPHEKDQQPVRRR-5.57813-6.34413
HLA-B52:013W395253LLPHEKDQQPVRRR-6.27203-6.46213
HLA-B52:013W395253LLPHEKDQQPVRRR-4.1761-4.9421
HLA-A11:014UQ25253LLPHEKDQQPVRRR-7.18219-7.94819
HLA-A24:025HGA5253LLPHEKDQQPVRRR-5.68083-5.87093
HLA-A24:025HGA5253LLPHEKDQQPVRRR-5.27642-6.04242
HLA-B44:053DX85253LLPHEKDQQPVRRR-6.40934-6.59944
HLA-B44:053DX85253LLPHEKDQQPVRRR-3.31818-4.08418
HLA-B14:023BVN5254LLPHEKDQQQPVRR-7.9962-8.1096
HLA-B14:023BVN5254LLPHEKDQQQPVRR-5.70842-6.74372
HLA-B52:013W395254LLPHEKDQQQPVRR-6.83737-6.95077
HLA-B52:013W395254LLPHEKDQQQPVRR-4.4836-5.5189
HLA-A11:014UQ25254LLPHEKDQQQPVRR-10.0067-10.1201
HLA-A11:014UQ25254LLPHEKDQQQPVRR-9.03915-10.0745
HLA-A24:025HGA5254LLPHEKDQQQPVRR-6.56204-6.67544
HLA-A24:025HGA5254LLPHEKDQQQPVRR-5.42271-6.45801
HLA-B44:053DX85254LLPHEKDQQQPVRR-7.85648-8.89178
HLA-B44:053DX85254LLPHEKDQQQPVRR-5.3978-5.5112
HLA-A02:016TDR5254LLPHEKDQQQPVRR-3.37154-4.40684

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Vaccine Design for the FusionNeoAntigens of KAT6B-KANSL1

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
KAT6B-KANSL1chr1076603236chr17441116511121KDQQPVRRRRGACCAGCAGCCAGTAAGGAGGAGAAGGGGA
KAT6B-KANSL1chr1076603236chr17441116511121KDQQQPVRRRGACCAGCAGCAGCCAGTAAGGAGGAGAAGG
KAT6B-KANSL1chr1076603236chr17441116511122KDQQQPVRRRRGACCAGCAGCAGCCAGTAAGGAGGAGAAGGGGA
KAT6B-KANSL1chr1076603236chr1744111651717LPHEKDQQPVCCCCATGAGAAAGACCAGCAGCCAGTAAGG
KAT6B-KANSL1chr1076603236chr1744111651918HEKDQQPVRGAGAAAGACCAGCAGCCAGTAAGGAGG
KAT6B-KANSL1chr1076603236chr1744111651918HEKDQQQPVGAGAAAGACCAGCAGCAGCCAGTAAGG

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
KAT6B-KANSL1chr1076603236chr1744111651116LPPVSLLPHEKDQQPCCACCTGTCAGCCTTCTACCCCATGAGAAAGACCAGCAGCCAGTA
KAT6B-KANSL1chr1076603236chr1744111651116LPPVSLLPHEKDQQQCCACCTGTCAGCCTTCTACCCCATGAGAAAGACCAGCAGCAGCCA
KAT6B-KANSL1chr1076603236chr1744111651217PPVSLLPHEKDQQPVCCTGTCAGCCTTCTACCCCATGAGAAAGACCAGCAGCCAGTAAGG
KAT6B-KANSL1chr1076603236chr1744111651217PPVSLLPHEKDQQQPCCTGTCAGCCTTCTACCCCATGAGAAAGACCAGCAGCAGCCAGTA
KAT6B-KANSL1chr1076603236chr1744111651318PVSLLPHEKDQQPVRGTCAGCCTTCTACCCCATGAGAAAGACCAGCAGCCAGTAAGGAGG
KAT6B-KANSL1chr1076603236chr1744111651318PVSLLPHEKDQQQPVGTCAGCCTTCTACCCCATGAGAAAGACCAGCAGCAGCCAGTAAGG

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Information of the samples that have these potential fusion neoantigens of KAT6B-KANSL1

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
SARCKAT6B-KANSL1chr1076603236ENST00000287239chr1744111651ENST00000262419TCGA-HS-A5N8-01A
SARCKAT6B-KANSL1chr1076603236ENST00000287239chr1744111651ENST00000575318TCGA-HS-A5N8-01A

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Potential target of CAR-T therapy development for KAT6B-KANSL1

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to KAT6B-KANSL1

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KAT6B-KANSL1

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource