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Fusion Protein:KLC1-MARK3

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: KLC1-MARK3
	FusionPDB ID: 42831
	FusionGDB2.0 ID: 42831
		Hgene	Tgene
	Gene symbol	KLC1	MARK3
	Gene ID	3831	4140
	Gene name	kinesin light chain 1	microtubule affinity regulating kinase 3
	Synonyms	KLC\|KNS2\|KNS2A	CTAK1\|KP78\|PAR1A\|Par-1a\|VIPB
	Cytomap	14q32.33	14q32.32-q32.33
	Type of gene	protein-coding	protein-coding
	Description	kinesin light chain 1kinesin 2 60/70kDamedulloblastoma antigen MU-MB-2.50	MAP/microtubule affinity-regulating kinase 3C-TAK1ELKL motif kinase 2EMK-2cdc25C-associated protein kinase 1protein kinase STK10ser/Thr protein kinase PAR-1serine/threonine-protein kinase p78
	Modification date	20200313	20200313
	UniProtAcc	Q07866 Main function of 5'-partner protein: FUNCTION: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.	P27448 Main function of 5'-partner protein: FUNCTION: Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). {ECO:0000269\|PubMed:16980613, ECO:0000269\|PubMed:23666762, ECO:0000269\|PubMed:28087714}.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000246489, ENST00000334553, ENST00000347839, ENST00000348520, ENST00000380038, ENST00000389744, ENST00000445352, ENST00000452929, ENST00000553286, ENST00000554280, ENST00000555836, ENST00000557450, ENST00000557575,	ENST00000561071, ENST00000216288, ENST00000303622, ENST00000335102, ENST00000416682, ENST00000429436, ENST00000440884, ENST00000553942,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 12 X 6=648	16 X 19 X 9=2736
	# samples	16	21
	** MAII score	log2(16/648*10)=-2.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(21/2736*10)=-3.70360699721978 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: KLC1 [Title/Abstract] AND MARK3 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: KLC1 [Title/Abstract] AND MARK3 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	KLC1(104095831)-MARK3(103969219), # samples:3
Anticipated loss of major functional domain due to fusion event.	KLC1-MARK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KLC1-MARK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KLC1-MARK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KLC1-MARK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KLC1-MARK3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. KLC1-MARK3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. KLC1-MARK3 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MARK3	GO:0018105	peptidyl-serine phosphorylation	9543386
Tgene	MARK3	GO:0032092	positive regulation of protein binding	9543386
Tgene	MARK3	GO:0035331	negative regulation of hippo signaling	28087714
Tgene	MARK3	GO:0036289	peptidyl-serine autophosphorylation	9543386

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:104095831/chr14:103969219)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across KLC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MARK3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000348520	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915256	+	3014	1306	319	2988	889
ENST00000348520	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915256	+	3401	1306	319	3267	982
ENST00000348520	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915256	+	3870	1306	319	3270	983
ENST00000348520	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915256	+	3803	1306	319	3198	959
ENST00000348520	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915256	+	3750	1306	319	3150	943
ENST00000348520	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915256	+	3262	1306	319	3243	974
ENST00000348520	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915256	+	3340	1306	319	3339	1007
ENST00000380038	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915256	+	2988	1280	293	2962	889
ENST00000380038	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915256	+	3375	1280	293	3241	982
ENST00000380038	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915256	+	3844	1280	293	3244	983
ENST00000380038	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915256	+	3777	1280	293	3172	959
ENST00000380038	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915256	+	3724	1280	293	3124	943
ENST00000380038	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915256	+	3236	1280	293	3217	974
ENST00000380038	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915256	+	3314	1280	293	3313	1007
ENST00000389744	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915256	+	2964	1256	269	2938	889
ENST00000389744	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915256	+	3351	1256	269	3217	982
ENST00000389744	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915256	+	3820	1256	269	3220	983
ENST00000389744	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915256	+	3753	1256	269	3148	959
ENST00000389744	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915256	+	3700	1256	269	3100	943
ENST00000389744	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915256	+	3212	1256	269	3193	974
ENST00000389744	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915256	+	3290	1256	269	3289	1007
ENST00000557575	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915256	+	2954	1246	259	2928	889
ENST00000557575	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915256	+	3341	1246	259	3207	982
ENST00000557575	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915256	+	3810	1246	259	3210	983
ENST00000557575	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915256	+	3743	1246	259	3138	959
ENST00000557575	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915256	+	3690	1246	259	3090	943
ENST00000557575	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915256	+	3202	1246	259	3183	974
ENST00000557575	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915256	+	3280	1246	259	3279	1007
ENST00000553286	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915256	+	2954	1246	259	2928	889
ENST00000553286	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915256	+	3341	1246	259	3207	982
ENST00000553286	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915256	+	3810	1246	259	3210	983
ENST00000553286	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915256	+	3743	1246	259	3138	959
ENST00000553286	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915256	+	3690	1246	259	3090	943
ENST00000553286	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915256	+	3202	1246	259	3183	974
ENST00000553286	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915256	+	3280	1246	259	3279	1007
ENST00000347839	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915256	+	2954	1246	259	2928	889
ENST00000347839	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915256	+	3341	1246	259	3207	982
ENST00000347839	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915256	+	3810	1246	259	3210	983
ENST00000347839	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915256	+	3743	1246	259	3138	959
ENST00000347839	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915256	+	3690	1246	259	3090	943
ENST00000347839	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915256	+	3202	1246	259	3183	974
ENST00000347839	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915256	+	3280	1246	259	3279	1007
ENST00000555836	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915256	+	2954	1246	259	2928	889
ENST00000555836	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915256	+	3341	1246	259	3207	982
ENST00000555836	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915256	+	3810	1246	259	3210	983
ENST00000555836	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915256	+	3743	1246	259	3138	959
ENST00000555836	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915256	+	3690	1246	259	3090	943
ENST00000555836	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915256	+	3202	1246	259	3183	974
ENST00000555836	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915256	+	3280	1246	259	3279	1007
ENST00000334553	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915256	+	2954	1246	259	2928	889
ENST00000334553	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915256	+	3341	1246	259	3207	982
ENST00000334553	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915256	+	3810	1246	259	3210	983
ENST00000334553	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915256	+	3743	1246	259	3138	959
ENST00000334553	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915256	+	3690	1246	259	3090	943
ENST00000334553	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915256	+	3202	1246	259	3183	974
ENST00000334553	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915256	+	3280	1246	259	3279	1007
ENST00000246489	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915256	+	2950	1242	255	2924	889
ENST00000246489	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915256	+	3337	1242	255	3203	982
ENST00000246489	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915256	+	3806	1242	255	3206	983
ENST00000246489	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915256	+	3739	1242	255	3134	959
ENST00000246489	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915256	+	3686	1242	255	3086	943
ENST00000246489	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915256	+	3198	1242	255	3179	974
ENST00000246489	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915256	+	3276	1242	255	3275	1006
ENST00000557450	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915256	+	2950	1242	255	2924	889
ENST00000557450	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915256	+	3337	1242	255	3203	982
ENST00000557450	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915256	+	3806	1242	255	3206	983
ENST00000557450	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915256	+	3739	1242	255	3134	959
ENST00000557450	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915256	+	3686	1242	255	3086	943
ENST00000557450	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915256	+	3198	1242	255	3179	974
ENST00000557450	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915256	+	3276	1242	255	3275	1006
ENST00000554280	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915256	+	2950	1242	255	2924	889
ENST00000554280	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915256	+	3337	1242	255	3203	982
ENST00000554280	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915256	+	3806	1242	255	3206	983
ENST00000554280	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915256	+	3739	1242	255	3134	959
ENST00000554280	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915256	+	3686	1242	255	3086	943
ENST00000554280	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915256	+	3198	1242	255	3179	974
ENST00000554280	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915256	+	3276	1242	255	3275	1006
ENST00000452929	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915256	+	2950	1242	255	2924	889
ENST00000452929	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915256	+	3337	1242	255	3203	982
ENST00000452929	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915256	+	3806	1242	255	3206	983
ENST00000452929	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915256	+	3739	1242	255	3134	959
ENST00000452929	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915256	+	3686	1242	255	3086	943
ENST00000452929	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915256	+	3198	1242	255	3179	974
ENST00000452929	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915256	+	3276	1242	255	3275	1006
ENST00000445352	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915256	+	2888	1180	199	2862	887
ENST00000445352	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915256	+	3275	1180	199	3141	980
ENST00000445352	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915256	+	3744	1180	199	3144	981
ENST00000445352	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915256	+	3677	1180	199	3072	957
ENST00000445352	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915256	+	3624	1180	199	3024	941
ENST00000445352	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915256	+	3136	1180	199	3117	972
ENST00000445352	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915256	+	3214	1180	199	3213	1005
ENST00000348520	KLC1	chr14	104124113	+	ENST00000553942	MARK3	chr14	103969219	+	1175	811	319	828	169
ENST00000348520	KLC1	chr14	104124113	+	ENST00000335102	MARK3	chr14	103969219	+	1157	811	319	828	169
ENST00000380038	KLC1	chr14	104124113	+	ENST00000553942	MARK3	chr14	103969219	+	1149	785	293	802	169
ENST00000380038	KLC1	chr14	104124113	+	ENST00000335102	MARK3	chr14	103969219	+	1131	785	293	802	169
ENST00000389744	KLC1	chr14	104124113	+	ENST00000553942	MARK3	chr14	103969219	+	1125	761	269	778	169
ENST00000389744	KLC1	chr14	104124113	+	ENST00000335102	MARK3	chr14	103969219	+	1107	761	269	778	169
ENST00000557575	KLC1	chr14	104124113	+	ENST00000553942	MARK3	chr14	103969219	+	1115	751	259	768	169
ENST00000557575	KLC1	chr14	104124113	+	ENST00000335102	MARK3	chr14	103969219	+	1097	751	259	768	169
ENST00000553286	KLC1	chr14	104124113	+	ENST00000553942	MARK3	chr14	103969219	+	1115	751	259	768	169
ENST00000553286	KLC1	chr14	104124113	+	ENST00000335102	MARK3	chr14	103969219	+	1097	751	259	768	169
ENST00000347839	KLC1	chr14	104124113	+	ENST00000553942	MARK3	chr14	103969219	+	1115	751	259	768	169
ENST00000347839	KLC1	chr14	104124113	+	ENST00000335102	MARK3	chr14	103969219	+	1097	751	259	768	169
ENST00000555836	KLC1	chr14	104124113	+	ENST00000553942	MARK3	chr14	103969219	+	1115	751	259	768	169
ENST00000555836	KLC1	chr14	104124113	+	ENST00000335102	MARK3	chr14	103969219	+	1097	751	259	768	169
ENST00000334553	KLC1	chr14	104124113	+	ENST00000553942	MARK3	chr14	103969219	+	1115	751	259	768	169
ENST00000334553	KLC1	chr14	104124113	+	ENST00000335102	MARK3	chr14	103969219	+	1097	751	259	768	169
ENST00000246489	KLC1	chr14	104124113	+	ENST00000553942	MARK3	chr14	103969219	+	1111	747	255	764	169
ENST00000246489	KLC1	chr14	104124113	+	ENST00000335102	MARK3	chr14	103969219	+	1093	747	255	764	169
ENST00000557450	KLC1	chr14	104124113	+	ENST00000553942	MARK3	chr14	103969219	+	1111	747	255	764	169
ENST00000557450	KLC1	chr14	104124113	+	ENST00000335102	MARK3	chr14	103969219	+	1093	747	255	764	169
ENST00000554280	KLC1	chr14	104124113	+	ENST00000553942	MARK3	chr14	103969219	+	1111	747	255	764	169
ENST00000554280	KLC1	chr14	104124113	+	ENST00000335102	MARK3	chr14	103969219	+	1093	747	255	764	169
ENST00000452929	KLC1	chr14	104124113	+	ENST00000553942	MARK3	chr14	103969219	+	1111	747	255	764	169
ENST00000452929	KLC1	chr14	104124113	+	ENST00000335102	MARK3	chr14	103969219	+	1093	747	255	764	169
ENST00000445352	KLC1	chr14	104124113	+	ENST00000553942	MARK3	chr14	103969219	+	1055	691	199	708	169
ENST00000445352	KLC1	chr14	104124113	+	ENST00000335102	MARK3	chr14	103969219	+	1037	691	199	708	169
ENST00000348520	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915255	+	3014	1306	319	2988	889
ENST00000348520	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915255	+	3401	1306	319	3267	982
ENST00000348520	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915255	+	3870	1306	319	3270	983
ENST00000348520	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915255	+	3803	1306	319	3198	959
ENST00000348520	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915255	+	3750	1306	319	3150	943
ENST00000348520	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915255	+	3262	1306	319	3243	974
ENST00000348520	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915255	+	3340	1306	319	3339	1007
ENST00000380038	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915255	+	2988	1280	293	2962	889
ENST00000380038	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915255	+	3375	1280	293	3241	982
ENST00000380038	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915255	+	3844	1280	293	3244	983
ENST00000380038	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915255	+	3777	1280	293	3172	959
ENST00000380038	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915255	+	3724	1280	293	3124	943
ENST00000380038	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915255	+	3236	1280	293	3217	974
ENST00000380038	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915255	+	3314	1280	293	3313	1007
ENST00000389744	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915255	+	2964	1256	269	2938	889
ENST00000389744	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915255	+	3351	1256	269	3217	982
ENST00000389744	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915255	+	3820	1256	269	3220	983
ENST00000389744	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915255	+	3753	1256	269	3148	959
ENST00000389744	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915255	+	3700	1256	269	3100	943
ENST00000389744	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915255	+	3212	1256	269	3193	974
ENST00000389744	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915255	+	3290	1256	269	3289	1007
ENST00000557575	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915255	+	2954	1246	259	2928	889
ENST00000557575	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915255	+	3341	1246	259	3207	982
ENST00000557575	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915255	+	3810	1246	259	3210	983
ENST00000557575	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915255	+	3743	1246	259	3138	959
ENST00000557575	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915255	+	3690	1246	259	3090	943
ENST00000557575	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915255	+	3202	1246	259	3183	974
ENST00000557575	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915255	+	3280	1246	259	3279	1007
ENST00000553286	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915255	+	2954	1246	259	2928	889
ENST00000553286	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915255	+	3341	1246	259	3207	982
ENST00000553286	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915255	+	3810	1246	259	3210	983
ENST00000553286	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915255	+	3743	1246	259	3138	959
ENST00000553286	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915255	+	3690	1246	259	3090	943
ENST00000553286	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915255	+	3202	1246	259	3183	974
ENST00000553286	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915255	+	3280	1246	259	3279	1007
ENST00000347839	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915255	+	2954	1246	259	2928	889
ENST00000347839	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915255	+	3341	1246	259	3207	982
ENST00000347839	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915255	+	3810	1246	259	3210	983
ENST00000347839	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915255	+	3743	1246	259	3138	959
ENST00000347839	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915255	+	3690	1246	259	3090	943
ENST00000347839	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915255	+	3202	1246	259	3183	974
ENST00000347839	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915255	+	3280	1246	259	3279	1007
ENST00000555836	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915255	+	2954	1246	259	2928	889
ENST00000555836	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915255	+	3341	1246	259	3207	982
ENST00000555836	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915255	+	3810	1246	259	3210	983
ENST00000555836	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915255	+	3743	1246	259	3138	959
ENST00000555836	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915255	+	3690	1246	259	3090	943
ENST00000555836	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915255	+	3202	1246	259	3183	974
ENST00000555836	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915255	+	3280	1246	259	3279	1007
ENST00000334553	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915255	+	2954	1246	259	2928	889
ENST00000334553	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915255	+	3341	1246	259	3207	982
ENST00000334553	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915255	+	3810	1246	259	3210	983
ENST00000334553	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915255	+	3743	1246	259	3138	959
ENST00000334553	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915255	+	3690	1246	259	3090	943
ENST00000334553	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915255	+	3202	1246	259	3183	974
ENST00000334553	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915255	+	3280	1246	259	3279	1007
ENST00000246489	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915255	+	2950	1242	255	2924	889
ENST00000246489	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915255	+	3337	1242	255	3203	982
ENST00000246489	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915255	+	3806	1242	255	3206	983
ENST00000246489	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915255	+	3739	1242	255	3134	959
ENST00000246489	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915255	+	3686	1242	255	3086	943
ENST00000246489	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915255	+	3198	1242	255	3179	974
ENST00000246489	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915255	+	3276	1242	255	3275	1006
ENST00000557450	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915255	+	2950	1242	255	2924	889
ENST00000557450	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915255	+	3337	1242	255	3203	982
ENST00000557450	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915255	+	3806	1242	255	3206	983
ENST00000557450	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915255	+	3739	1242	255	3134	959
ENST00000557450	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915255	+	3686	1242	255	3086	943
ENST00000557450	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915255	+	3198	1242	255	3179	974
ENST00000557450	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915255	+	3276	1242	255	3275	1006
ENST00000554280	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915255	+	2950	1242	255	2924	889
ENST00000554280	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915255	+	3337	1242	255	3203	982
ENST00000554280	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915255	+	3806	1242	255	3206	983
ENST00000554280	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915255	+	3739	1242	255	3134	959
ENST00000554280	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915255	+	3686	1242	255	3086	943
ENST00000554280	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915255	+	3198	1242	255	3179	974
ENST00000554280	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915255	+	3276	1242	255	3275	1006
ENST00000452929	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915255	+	2950	1242	255	2924	889
ENST00000452929	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915255	+	3337	1242	255	3203	982
ENST00000452929	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915255	+	3806	1242	255	3206	983
ENST00000452929	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915255	+	3739	1242	255	3134	959
ENST00000452929	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915255	+	3686	1242	255	3086	943
ENST00000452929	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915255	+	3198	1242	255	3179	974
ENST00000452929	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915255	+	3276	1242	255	3275	1006
ENST00000445352	KLC1	chr14	104136620	+	ENST00000440884	MARK3	chr14	103915255	+	2888	1180	199	2862	887
ENST00000445352	KLC1	chr14	104136620	+	ENST00000416682	MARK3	chr14	103915255	+	3275	1180	199	3141	980
ENST00000445352	KLC1	chr14	104136620	+	ENST00000429436	MARK3	chr14	103915255	+	3744	1180	199	3144	981
ENST00000445352	KLC1	chr14	104136620	+	ENST00000303622	MARK3	chr14	103915255	+	3677	1180	199	3072	957
ENST00000445352	KLC1	chr14	104136620	+	ENST00000216288	MARK3	chr14	103915255	+	3624	1180	199	3024	941
ENST00000445352	KLC1	chr14	104136620	+	ENST00000553942	MARK3	chr14	103915255	+	3136	1180	199	3117	972
ENST00000445352	KLC1	chr14	104136620	+	ENST00000335102	MARK3	chr14	103915255	+	3214	1180	199	3213	1005

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000348520	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.004671217	0.9953288
ENST00000348520	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001938727	0.99806124
ENST00000348520	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.00104732	0.9989526
ENST00000348520	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.000957585	0.99904233
ENST00000348520	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001099287	0.99890065
ENST00000348520	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.002367779	0.99763215
ENST00000348520	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001626252	0.99837375
ENST00000380038	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.004555324	0.99544466
ENST00000380038	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001853582	0.9981464
ENST00000380038	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.000998968	0.9990011
ENST00000380038	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.000939391	0.9990606
ENST00000380038	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001076705	0.99892324
ENST00000380038	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.002238815	0.99776113
ENST00000380038	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001555772	0.99844426
ENST00000389744	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.004633189	0.9953668
ENST00000389744	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001827713	0.9981723
ENST00000389744	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.000978102	0.9990219
ENST00000389744	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.00094335	0.99905664
ENST00000389744	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001082217	0.9989178
ENST00000389744	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.002213074	0.9977869
ENST00000389744	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001530849	0.9984692
ENST00000557575	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.004402697	0.9955973
ENST00000557575	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001756544	0.99824345
ENST00000557575	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.000944766	0.9990552
ENST00000557575	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.000916947	0.99908304
ENST00000557575	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001052242	0.9989478
ENST00000557575	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.002088028	0.997912
ENST00000557575	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001466131	0.99853384
ENST00000553286	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.004402697	0.9955973
ENST00000553286	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001756544	0.99824345
ENST00000553286	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.000944766	0.9990552
ENST00000553286	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.000916947	0.99908304
ENST00000553286	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001052242	0.9989478
ENST00000553286	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.002088028	0.997912
ENST00000553286	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001466131	0.99853384
ENST00000347839	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.004402697	0.9955973
ENST00000347839	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001756544	0.99824345
ENST00000347839	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.000944766	0.9990552
ENST00000347839	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.000916947	0.99908304
ENST00000347839	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001052242	0.9989478
ENST00000347839	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.002088028	0.997912
ENST00000347839	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001466131	0.99853384
ENST00000555836	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.004402697	0.9955973
ENST00000555836	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001756544	0.99824345
ENST00000555836	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.000944766	0.9990552
ENST00000555836	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.000916947	0.99908304
ENST00000555836	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001052242	0.9989478
ENST00000555836	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.002088028	0.997912
ENST00000555836	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001466131	0.99853384
ENST00000334553	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.004402697	0.9955973
ENST00000334553	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001756544	0.99824345
ENST00000334553	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.000944766	0.9990552
ENST00000334553	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.000916947	0.99908304
ENST00000334553	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001052242	0.9989478
ENST00000334553	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.002088028	0.997912
ENST00000334553	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001466131	0.99853384
ENST00000246489	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.004363495	0.9956365
ENST00000246489	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001735776	0.99826425
ENST00000246489	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.00093633	0.9990637
ENST00000246489	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.000910875	0.9990891
ENST00000246489	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001045967	0.99895406
ENST00000246489	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.002061282	0.9979387
ENST00000246489	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001447473	0.9985525
ENST00000557450	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.004363495	0.9956365
ENST00000557450	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001735776	0.99826425
ENST00000557450	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.00093633	0.9990637
ENST00000557450	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.000910875	0.9990891
ENST00000557450	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001045967	0.99895406
ENST00000557450	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.002061282	0.9979387
ENST00000557450	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001447473	0.9985525
ENST00000554280	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.004363495	0.9956365
ENST00000554280	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001735776	0.99826425
ENST00000554280	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.00093633	0.9990637
ENST00000554280	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.000910875	0.9990891
ENST00000554280	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001045967	0.99895406
ENST00000554280	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.002061282	0.9979387
ENST00000554280	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001447473	0.9985525
ENST00000452929	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.004363495	0.9956365
ENST00000452929	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001735776	0.99826425
ENST00000452929	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.00093633	0.9990637
ENST00000452929	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.000910875	0.9990891
ENST00000452929	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001045967	0.99895406
ENST00000452929	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.002061282	0.9979387
ENST00000452929	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001447473	0.9985525
ENST00000445352	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.005444194	0.99455583
ENST00000445352	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001820636	0.99817944
ENST00000445352	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.000941999	0.99905795
ENST00000445352	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001024622	0.9989754
ENST00000445352	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.000860321	0.99913967
ENST00000445352	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.00244127	0.9975587
ENST00000445352	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915256	+	0.001462749	0.9985373
ENST00000348520	ENST00000553942	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.005672791	0.99432725
ENST00000348520	ENST00000335102	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.005704084	0.9942959
ENST00000380038	ENST00000553942	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.004648544	0.99535143
ENST00000380038	ENST00000335102	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.004685117	0.99531484
ENST00000389744	ENST00000553942	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.005275881	0.9947241
ENST00000389744	ENST00000335102	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.005275292	0.9947247
ENST00000557575	ENST00000553942	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.005842367	0.9941577
ENST00000557575	ENST00000335102	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.006094297	0.9939057
ENST00000553286	ENST00000553942	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.005842367	0.9941577
ENST00000553286	ENST00000335102	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.006094297	0.9939057
ENST00000347839	ENST00000553942	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.005842367	0.9941577
ENST00000347839	ENST00000335102	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.006094297	0.9939057
ENST00000555836	ENST00000553942	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.005842367	0.9941577
ENST00000555836	ENST00000335102	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.006094297	0.9939057
ENST00000334553	ENST00000553942	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.005842367	0.9941577
ENST00000334553	ENST00000335102	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.006094297	0.9939057
ENST00000246489	ENST00000553942	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.005287164	0.99471277
ENST00000246489	ENST00000335102	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.005462799	0.9945372
ENST00000557450	ENST00000553942	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.005287164	0.99471277
ENST00000557450	ENST00000335102	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.005462799	0.9945372
ENST00000554280	ENST00000553942	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.005287164	0.99471277
ENST00000554280	ENST00000335102	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.005462799	0.9945372
ENST00000452929	ENST00000553942	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.005287164	0.99471277
ENST00000452929	ENST00000335102	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.005462799	0.9945372
ENST00000445352	ENST00000553942	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.004096032	0.995904
ENST00000445352	ENST00000335102	KLC1	chr14	104124113	+	MARK3	chr14	103969219	+	0.004081496	0.9959186
ENST00000348520	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.004671217	0.9953288
ENST00000348520	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001938727	0.99806124
ENST00000348520	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.00104732	0.9989526
ENST00000348520	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.000957585	0.99904233
ENST00000348520	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001099287	0.99890065
ENST00000348520	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.002367779	0.99763215
ENST00000348520	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001626252	0.99837375
ENST00000380038	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.004555324	0.99544466
ENST00000380038	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001853582	0.9981464
ENST00000380038	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.000998968	0.9990011
ENST00000380038	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.000939391	0.9990606
ENST00000380038	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001076705	0.99892324
ENST00000380038	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.002238815	0.99776113
ENST00000380038	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001555772	0.99844426
ENST00000389744	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.004633189	0.9953668
ENST00000389744	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001827713	0.9981723
ENST00000389744	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.000978102	0.9990219
ENST00000389744	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.00094335	0.99905664
ENST00000389744	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001082217	0.9989178
ENST00000389744	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.002213074	0.9977869
ENST00000389744	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001530849	0.9984692
ENST00000557575	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.004402697	0.9955973
ENST00000557575	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001756544	0.99824345
ENST00000557575	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.000944766	0.9990552
ENST00000557575	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.000916947	0.99908304
ENST00000557575	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001052242	0.9989478
ENST00000557575	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.002088028	0.997912
ENST00000557575	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001466131	0.99853384
ENST00000553286	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.004402697	0.9955973
ENST00000553286	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001756544	0.99824345
ENST00000553286	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.000944766	0.9990552
ENST00000553286	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.000916947	0.99908304
ENST00000553286	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001052242	0.9989478
ENST00000553286	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.002088028	0.997912
ENST00000553286	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001466131	0.99853384
ENST00000347839	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.004402697	0.9955973
ENST00000347839	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001756544	0.99824345
ENST00000347839	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.000944766	0.9990552
ENST00000347839	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.000916947	0.99908304
ENST00000347839	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001052242	0.9989478
ENST00000347839	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.002088028	0.997912
ENST00000347839	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001466131	0.99853384
ENST00000555836	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.004402697	0.9955973
ENST00000555836	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001756544	0.99824345
ENST00000555836	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.000944766	0.9990552
ENST00000555836	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.000916947	0.99908304
ENST00000555836	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001052242	0.9989478
ENST00000555836	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.002088028	0.997912
ENST00000555836	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001466131	0.99853384
ENST00000334553	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.004402697	0.9955973
ENST00000334553	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001756544	0.99824345
ENST00000334553	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.000944766	0.9990552
ENST00000334553	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.000916947	0.99908304
ENST00000334553	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001052242	0.9989478
ENST00000334553	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.002088028	0.997912
ENST00000334553	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001466131	0.99853384
ENST00000246489	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.004363495	0.9956365
ENST00000246489	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001735776	0.99826425
ENST00000246489	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.00093633	0.9990637
ENST00000246489	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.000910875	0.9990891
ENST00000246489	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001045967	0.99895406
ENST00000246489	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.002061282	0.9979387
ENST00000246489	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001447473	0.9985525
ENST00000557450	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.004363495	0.9956365
ENST00000557450	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001735776	0.99826425
ENST00000557450	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.00093633	0.9990637
ENST00000557450	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.000910875	0.9990891
ENST00000557450	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001045967	0.99895406
ENST00000557450	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.002061282	0.9979387
ENST00000557450	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001447473	0.9985525
ENST00000554280	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.004363495	0.9956365
ENST00000554280	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001735776	0.99826425
ENST00000554280	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.00093633	0.9990637
ENST00000554280	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.000910875	0.9990891
ENST00000554280	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001045967	0.99895406
ENST00000554280	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.002061282	0.9979387
ENST00000554280	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001447473	0.9985525
ENST00000452929	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.004363495	0.9956365
ENST00000452929	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001735776	0.99826425
ENST00000452929	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.00093633	0.9990637
ENST00000452929	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.000910875	0.9990891
ENST00000452929	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001045967	0.99895406
ENST00000452929	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.002061282	0.9979387
ENST00000452929	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001447473	0.9985525
ENST00000445352	ENST00000440884	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.005444194	0.99455583
ENST00000445352	ENST00000416682	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001820636	0.99817944
ENST00000445352	ENST00000429436	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.000941999	0.99905795
ENST00000445352	ENST00000303622	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001024622	0.9989754
ENST00000445352	ENST00000216288	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.000860321	0.99913967
ENST00000445352	ENST00000553942	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.00244127	0.9975587
ENST00000445352	ENST00000335102	KLC1	chr14	104136620	+	MARK3	chr14	103915255	+	0.001462749	0.9985373

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for KLC1-MARK3

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
KLC1	chr14	104136620	MARK3	chr14	103915255	1180	327	EPLCKRALEIREKLFREVRIMKILNH
KLC1	chr14	104136620	MARK3	chr14	103915255	1242	329	EPLCKRALEIREKLFREVRIMKILNH
KLC1	chr14	104136620	MARK3	chr14	103915255	1246	329	EPLCKRALEIREKLFREVRIMKILNH
KLC1	chr14	104136620	MARK3	chr14	103915255	1256	329	EPLCKRALEIREKLFREVRIMKILNH
KLC1	chr14	104136620	MARK3	chr14	103915255	1280	329	EPLCKRALEIREKLFREVRIMKILNH
KLC1	chr14	104136620	MARK3	chr14	103915255	1306	329	EPLCKRALEIREKLFREVRIMKILNH
KLC1	chr14	104136620	MARK3	chr14	103915256	1180	327	EPLCKRALEIREKLFREVRIMKILNH
KLC1	chr14	104136620	MARK3	chr14	103915256	1242	329	EPLCKRALEIREKLFREVRIMKILNH
KLC1	chr14	104136620	MARK3	chr14	103915256	1246	329	EPLCKRALEIREKLFREVRIMKILNH
KLC1	chr14	104136620	MARK3	chr14	103915256	1256	329	EPLCKRALEIREKLFREVRIMKILNH
KLC1	chr14	104136620	MARK3	chr14	103915256	1280	329	EPLCKRALEIREKLFREVRIMKILNH
KLC1	chr14	104136620	MARK3	chr14	103915256	1306	329	EPLCKRALEIREKLFREVRIMKILNH

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Potential FusionNeoAntigen Information of KLC1-MARK3 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

KLC1-MARK3_104136620_103915255.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B18:01	LEIREKLF	0.998	0.8733	7	15
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B57:03	RALEIREKL	0.993	0.9731	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-A32:13	KLFREVRIM	0.8783	0.9188	12	21
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B13:02	RALEIREKL	0.7055	0.5893	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B13:01	RALEIREKL	0.458	0.9647	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B52:01	RALEIREKL	0.3736	0.8642	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B27:02	KRALEIREKL	0.9999	0.6542	4	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B27:05	KRALEIREKL	0.9999	0.9058	4	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B27:04	KRALEIREKL	0.9998	0.7522	4	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B57:01	RALEIREKLF	0.9997	0.9508	5	15
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B58:02	RALEIREKLF	0.9991	0.9101	5	15
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B57:03	RALEIREKLF	0.9985	0.9677	5	15
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B58:01	RALEIREKLF	0.9974	0.8709	5	15
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-A30:08	KLFREVRIMK	0.9945	0.7411	12	22
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B27:02	KRALEIREKLF	1	0.528	4	15
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B40:06	REKLFREV	0.9999	0.6866	10	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C15:04	RALEIREKL	0.9998	0.9406	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C15:06	RALEIREKL	0.9997	0.9466	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C03:19	RALEIREKL	0.9993	0.9916	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C03:07	RALEIREKL	0.9992	0.9867	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C03:08	RALEIREKL	0.9984	0.9125	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C04:06	RALEIREKL	0.9939	0.7962	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C03:14	RALEIREKL	0.9889	0.9821	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C08:04	RALEIREKL	0.9779	0.9622	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C08:13	RALEIREKL	0.9779	0.9622	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C02:06	RALEIREKL	0.9774	0.9552	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B15:07	KLFREVRIM	0.9588	0.6508	12	21
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B15:04	KLFREVRIM	0.9364	0.9133	12	21
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C06:03	RALEIREKL	0.8725	0.9927	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C12:04	RALEIREKL	0.8667	0.9921	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C08:03	RALEIREKL	0.8664	0.9907	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C12:12	RALEIREKL	0.8215	0.9481	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B27:14	KRALEIREKL	0.9999	0.8195	4	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B27:03	KRALEIREKL	0.9961	0.9239	4	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B18:05	LEIREKLF	0.998	0.8733	7	15
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C15:09	RALEIREKL	0.9998	0.9406	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C15:05	RALEIREKL	0.9997	0.9313	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C15:02	RALEIREKL	0.9996	0.9282	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C03:17	RALEIREKL	0.9984	0.9777	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C03:05	RALEIREKL	0.9982	0.9407	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C03:03	RALEIREKL	0.995	0.9903	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C03:04	RALEIREKL	0.995	0.9903	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C16:02	RALEIREKL	0.9943	0.9937	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C16:01	RALEIREKL	0.9929	0.9833	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-A32:01	RALEIREKL	0.9911	0.9451	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C02:10	RALEIREKL	0.9665	0.9779	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C02:02	RALEIREKL	0.9665	0.9779	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C17:01	RALEIREKL	0.9662	0.958	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-A32:01	KLFREVRIM	0.9635	0.9437	12	21
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C03:06	RALEIREKL	0.9594	0.9913	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B15:35	KLFREVRIM	0.9578	0.8621	12	21
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C16:04	RALEIREKL	0.9507	0.9789	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C08:01	RALEIREKL	0.8664	0.9907	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C12:03	RALEIREKL	0.8664	0.9776	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B15:39	KLFREVRIM	0.8537	0.7683	12	21
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C06:08	IREKLFREV	0.7729	0.9781	9	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B07:13	RALEIREKL	0.7363	0.7937	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B35:13	RALEIREKL	0.7304	0.9192	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B15:73	KLFREVRIM	0.7041	0.7046	12	21
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B39:02	RALEIREKL	0.6084	0.9484	5	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B15:30	KLFREVRIM	0.4932	0.6946	12	21
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C06:02	IREKLFREV	0.0465	0.9931	9	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-C06:17	IREKLFREV	0.0465	0.9931	9	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B27:10	KRALEIREKL	0.9999	0.889	4	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B27:08	KRALEIREKL	0.9999	0.8098	4	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B27:06	KRALEIREKL	0.9997	0.76	4	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B57:10	RALEIREKLF	0.9997	0.9508	5	15
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B27:09	KRALEIREKL	0.9995	0.8672	4	14
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B58:06	RALEIREKLF	0.9993	0.8567	5	15
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B57:04	RALEIREKLF	0.9988	0.7304	5	15
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-B57:02	RALEIREKLF	0.9954	0.913	5	15
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	HLA-A30:01	KLFREVRIMK	0.9937	0.8047	12	22

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Potential FusionNeoAntigen Information of KLC1-MARK3 in HLA II

KLC1-MARK3_104136620_103915255.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1102	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1102	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1102	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1102	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1103	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1114	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1114	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1116	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1116	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1116	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1116	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1120	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1120	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1121	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1121	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1121	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1121	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1136	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1136	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1136	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1148	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1148	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1155	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1155	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1159	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1163	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1165	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1165	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1165	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1165	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1168	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1168	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1170	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1170	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1170	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1170	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1176	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1185	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1186	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1186	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1301	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1301	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1301	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1301	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1302	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1302	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1304	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1308	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1308	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1315	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1315	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1315	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1315	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1316	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1316	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1317	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1317	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1317	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1319	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1319	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1320	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1320	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1320	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1322	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1322	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1322	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1322	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1323	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1323	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1324	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1327	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1327	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1327	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1329	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1329	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1334	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1334	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1335	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1335	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1335	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1335	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1339	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1339	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1341	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1343	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1351	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1351	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1351	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1351	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1352	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1352	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1352	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1352	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1353	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1353	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1357	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1357	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1357	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1357	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1359	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1359	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1359	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1359	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1361	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1361	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1361	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1361	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1364	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1364	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1364	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1364	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1368	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1368	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1368	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1368	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1369	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1369	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1369	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1369	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1370	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1370	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1371	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1371	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1371	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1372	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1372	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1373	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1373	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1374	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1374	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1378	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1378	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1378	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1379	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1379	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1379	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1379	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1380	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1380	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1380	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1380	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1383	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1383	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1383	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1383	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1384	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1384	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1387	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1387	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1387	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1387	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1391	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1391	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1391	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1391	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1392	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1392	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1392	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1392	RALEIREKLFREVRI	5	20
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1393	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1396	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1396	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1397	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1397	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1398	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1398	CKRALEIREKLFREV	3	18
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1398	LCKRALEIREKLFRE	2	17
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1399	KRALEIREKLFREVR	4	19
KLC1-MARK3	chr14	104136620	chr14	103915255	1242	DRB1-1399	CKRALEIREKLFREV	3	18

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Fusion breakpoint peptide structures of KLC1-MARK3

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
352	ALEIREKLFREVRI	KLC1	MARK3	chr14	104136620	chr14	103915255	1242

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of KLC1-MARK3

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	352	ALEIREKLFREVRI	-7.15543	-7.26883
HLA-B14:02	3BVN	352	ALEIREKLFREVRI	-4.77435	-5.80965
HLA-B52:01	3W39	352	ALEIREKLFREVRI	-6.80875	-6.92215
HLA-B52:01	3W39	352	ALEIREKLFREVRI	-4.20386	-5.23916
HLA-A11:01	4UQ2	352	ALEIREKLFREVRI	-7.5194	-8.5547
HLA-A11:01	4UQ2	352	ALEIREKLFREVRI	-6.9601	-7.0735
HLA-A24:02	5HGA	352	ALEIREKLFREVRI	-7.52403	-7.63743
HLA-A24:02	5HGA	352	ALEIREKLFREVRI	-5.82433	-6.85963
HLA-B27:05	6PYJ	352	ALEIREKLFREVRI	-3.28285	-4.31815
HLA-B44:05	3DX8	352	ALEIREKLFREVRI	-5.91172	-6.94702
HLA-B44:05	3DX8	352	ALEIREKLFREVRI	-4.24346	-4.35686

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Vaccine Design for the FusionNeoAntigens of KLC1-MARK3

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
KLC1-MARK3	chr14	104136620	chr14	103915255	10	18	REKLFREV	CGAGAAAAGCTCTTCAGAGAAGTA
KLC1-MARK3	chr14	104136620	chr14	103915255	12	21	KLFREVRIM	AAGCTCTTCAGAGAAGTAAGAATAATG
KLC1-MARK3	chr14	104136620	chr14	103915255	12	22	KLFREVRIMK	AAGCTCTTCAGAGAAGTAAGAATAATGAAG
KLC1-MARK3	chr14	104136620	chr14	103915255	4	14	KRALEIREKL	AAAAGAGCTCTGGAAATCCGAGAAAAGCTC
KLC1-MARK3	chr14	104136620	chr14	103915255	4	15	KRALEIREKLF	AAAAGAGCTCTGGAAATCCGAGAAAAGCTCTTC
KLC1-MARK3	chr14	104136620	chr14	103915255	5	14	RALEIREKL	AGAGCTCTGGAAATCCGAGAAAAGCTC
KLC1-MARK3	chr14	104136620	chr14	103915255	5	15	RALEIREKLF	AGAGCTCTGGAAATCCGAGAAAAGCTCTTC
KLC1-MARK3	chr14	104136620	chr14	103915255	7	15	LEIREKLF	CTGGAAATCCGAGAAAAGCTCTTC
KLC1-MARK3	chr14	104136620	chr14	103915255	9	18	IREKLFREV	ATCCGAGAAAAGCTCTTCAGAGAAGTA

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
KLC1-MARK3	chr14	104136620	chr14	103915255	2	17	LCKRALEIREKLFRE	TTGTGTAAAAGAGCTCTGGAAATCCGAGAAAAGCTCTTCAGAGAA
KLC1-MARK3	chr14	104136620	chr14	103915255	3	18	CKRALEIREKLFREV	TGTAAAAGAGCTCTGGAAATCCGAGAAAAGCTCTTCAGAGAAGTA
KLC1-MARK3	chr14	104136620	chr14	103915255	4	19	KRALEIREKLFREVR	AAAAGAGCTCTGGAAATCCGAGAAAAGCTCTTCAGAGAAGTAAGA
KLC1-MARK3	chr14	104136620	chr14	103915255	5	20	RALEIREKLFREVRI	AGAGCTCTGGAAATCCGAGAAAAGCTCTTCAGAGAAGTAAGAATA

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Information of the samples that have these potential fusion neoantigens of KLC1-MARK3

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
BRCA	KLC1-MARK3	chr14	104136620	ENST00000246489	chr14	103915255	ENST00000216288	TCGA-D8-A1JK

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Potential target of CAR-T therapy development for KLC1-MARK3

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to KLC1-MARK3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to KLC1-MARK3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)