Home

Download

Statistics

Examples

Help

Contact

Fusion Protein:MGA-RTF1

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MGA-RTF1
	FusionPDB ID: 53305
	FusionGDB2.0 ID: 53305
		Hgene	Tgene
	Gene symbol	MGA	RTF1
	Gene ID	23269	23168
	Gene name	MAX dimerization protein MGA	RTF1 homolog, Paf1/RNA polymerase II complex component
	Synonyms	MAD5\|MXD5	GTL7\|KIAA0252
	Cytomap	15q15.1	15q15.1
	Type of gene	protein-coding	protein-coding
	Description	MAX gene-associated proteinMAX dimerization protein 5MGA, MAX dimerization protein	RNA polymerase-associated protein RTF1 homologRtf1, Paf1/RNA polymerase II complex component, homologortholog of mouse gene trap locus 7
	Modification date	20200313	20200313
	UniProtAcc	Q3V5L5 Main function of 5'-partner protein: FUNCTION: Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1,2-Man-alpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAc-beta1,2-Man-alpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway. {ECO:0000269\|PubMed:12941944, ECO:0000269\|PubMed:14617637, ECO:0000269\|PubMed:14623122, ECO:0000269\|PubMed:16606368, ECO:0000269\|PubMed:16857188, ECO:0000269\|PubMed:19846580}.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000219905, ENST00000389936, ENST00000545763, ENST00000566586, ENST00000570161, ENST00000568630,	ENST00000462276, ENST00000389629,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	17 X 14 X 11=2618	14 X 10 X 5=700
	# samples	18	15
	** MAII score	log2(18/2618*10)=-3.86239628561557 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/700*10)=-2.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: MGA [Title/Abstract] AND RTF1 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: MGA [Title/Abstract] AND RTF1 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MGA(42028896)-RTF1(41730519), # samples:2
Anticipated loss of major functional domain due to fusion event.	MGA-RTF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MGA-RTF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MGA-RTF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MGA-RTF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	RTF1	GO:0019827	stem cell population maintenance	19345177
Tgene	RTF1	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	20178742
Tgene	RTF1	GO:0045944	positive regulation of transcription by RNA polymerase II	20178742

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:42028896/chr15:41730519)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across MGA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RTF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000545763	MGA	chr15	42028896	+	ENST00000389629	RTF1	chr15	41730519	+	9426	4615	181	6549	2122
ENST00000389936	MGA	chr15	42028896	+	ENST00000389629	RTF1	chr15	41730519	+	9426	4615	181	6549	2122
ENST00000219905	MGA	chr15	42028896	+	ENST00000389629	RTF1	chr15	41730519	+	9426	4615	181	6549	2122
ENST00000566586	MGA	chr15	42028896	+	ENST00000389629	RTF1	chr15	41730519	+	9312	4501	67	6435	2122
ENST00000570161	MGA	chr15	42028896	+	ENST00000389629	RTF1	chr15	41730519	+	9245	4434	0	6368	2122
ENST00000545763	MGA	chr15	42021547	+	ENST00000389629	RTF1	chr15	41730519	+	8835	4024	181	5958	1925
ENST00000389936	MGA	chr15	42021547	+	ENST00000389629	RTF1	chr15	41730519	+	8835	4024	181	5958	1925
ENST00000219905	MGA	chr15	42021547	+	ENST00000389629	RTF1	chr15	41730519	+	8835	4024	181	5958	1925
ENST00000566586	MGA	chr15	42021547	+	ENST00000389629	RTF1	chr15	41730519	+	8721	3910	67	5844	1925
ENST00000570161	MGA	chr15	42021547	+	ENST00000389629	RTF1	chr15	41730519	+	8654	3843	0	5777	1925

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000545763	ENST00000389629	MGA	chr15	42028896	+	RTF1	chr15	41730519	+	0.000331404	0.9996686
ENST00000389936	ENST00000389629	MGA	chr15	42028896	+	RTF1	chr15	41730519	+	0.000331404	0.9996686
ENST00000219905	ENST00000389629	MGA	chr15	42028896	+	RTF1	chr15	41730519	+	0.000331404	0.9996686
ENST00000566586	ENST00000389629	MGA	chr15	42028896	+	RTF1	chr15	41730519	+	0.000294896	0.99970514
ENST00000570161	ENST00000389629	MGA	chr15	42028896	+	RTF1	chr15	41730519	+	0.000283005	0.99971694
ENST00000545763	ENST00000389629	MGA	chr15	42021547	+	RTF1	chr15	41730519	+	0.001195984	0.998804
ENST00000389936	ENST00000389629	MGA	chr15	42021547	+	RTF1	chr15	41730519	+	0.001195984	0.998804
ENST00000219905	ENST00000389629	MGA	chr15	42021547	+	RTF1	chr15	41730519	+	0.001195984	0.998804
ENST00000566586	ENST00000389629	MGA	chr15	42021547	+	RTF1	chr15	41730519	+	0.001046874	0.9989531
ENST00000570161	ENST00000389629	MGA	chr15	42021547	+	RTF1	chr15	41730519	+	0.000995916	0.99900407

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

Top

Fusion Protein Breakpoint Sequences for MGA-RTF1

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
MGA	chr15	42021547	RTF1	chr15	41730519	3843	1281	SCHSSPENHNNAKELLSLAKRKRSDS
MGA	chr15	42021547	RTF1	chr15	41730519	3910	1281	SCHSSPENHNNAKELLSLAKRKRSDS
MGA	chr15	42021547	RTF1	chr15	41730519	4024	1281	SCHSSPENHNNAKELLSLAKRKRSDS
MGA	chr15	42028896	RTF1	chr15	41730519	4434	1478	KRKPSSSTSGLIQELLSLAKRKRSDS
MGA	chr15	42028896	RTF1	chr15	41730519	4501	1478	KRKPSSSTSGLIQELLSLAKRKRSDS
MGA	chr15	42028896	RTF1	chr15	41730519	4615	1478	KRKPSSSTSGLIQELLSLAKRKRSDS

Top

Potential FusionNeoAntigen Information of MGA-RTF1 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

MGA-RTF1_42021547_41730519.msa
MGA-RTF1_42028896_41730519.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:01	NHNNAKEL	0.9995	0.9323	7	15
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B38:02	NHNNAKEL	0.9989	0.9564	7	15
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B38:01	NHNNAKEL	0.9988	0.9321	7	15
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B15:10	NHNNAKEL	0.9988	0.6369	7	15
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B08:01	NAKELLSL	0.9974	0.5173	10	18
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B08:09	NAKELLSL	0.9969	0.581	10	18
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B15:37	NHNNAKEL	0.9728	0.7135	7	15
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:01	NHNNAKELL	0.9987	0.9296	7	16
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B38:01	NHNNAKELL	0.9972	0.9418	7	16
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B38:02	NHNNAKELL	0.9971	0.9624	7	16
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:06	NHNNAKELL	0.9962	0.7509	7	16
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B15:10	NHNNAKELL	0.9913	0.6567	7	16
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B15:37	NHNNAKELL	0.9276	0.7108	7	16
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B08:09	NAKELLSLA	0.8864	0.5317	10	19
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B15:18	NHNNAKELL	0.703	0.7725	7	16
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:01	ENHNNAKELL	0.6854	0.9304	6	16
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B38:01	ENHNNAKELL	0.5693	0.9201	6	16
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B38:02	ENHNNAKELL	0.5677	0.9471	6	16
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:01	NHNNAKELLSL	0.9999	0.9334	7	18
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B38:02	NHNNAKELLSL	0.9998	0.9576	7	18
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B38:01	NHNNAKELLSL	0.9996	0.9405	7	18
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B15:10	NHNNAKELLSL	0.9983	0.5345	7	18
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B15:37	NHNNAKELLSL	0.9911	0.5957	7	18
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:09	NHNNAKEL	0.9996	0.5418	7	15
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:12	NHNNAKEL	0.9993	0.937	7	15
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:05	NHNNAKEL	0.999	0.9206	7	15
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B14:03	NHNNAKEL	0.7681	0.7703	7	15
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:09	NHNNAKELL	0.9989	0.5559	7	16
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:12	NHNNAKELL	0.9983	0.9346	7	16
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:05	NHNNAKELL	0.997	0.915	7	16
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B14:03	NNAKELLSL	0.7436	0.723	9	18
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B14:03	NHNNAKELL	0.2134	0.7628	7	16
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:05	ENHNNAKELL	0.57	0.9168	6	16
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:12	NHNNAKELLSL	0.9999	0.9362	7	18
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:09	NHNNAKELLSL	0.9998	0.5405	7	18
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:05	NHNNAKELLSL	0.9997	0.9155	7	18
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B07:12	SPENHNNAKEL	0.9995	0.5059	4	15
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B14:03	NHNNAKELLSL	0.9964	0.8055	7	18
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:10	SPENHNNAKEL	0.9425	0.9354	4	15
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:31	NHNNAKEL	0.9995	0.932	7	15
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B38:05	NHNNAKEL	0.9988	0.9321	7	15
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-C16:01	NAKELLSL	0.9974	0.9674	10	18
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B08:18	NAKELLSL	0.9974	0.5173	10	18
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B08:12	NAKELLSL	0.9842	0.7237	10	18
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:11	NHNNAKEL	0.856	0.7359	7	15
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:31	NHNNAKELL	0.9989	0.9294	7	16
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B38:05	NHNNAKELL	0.9972	0.9418	7	16
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B15:09	NHNNAKELL	0.991	0.5112	7	16
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:11	NHNNAKELL	0.8513	0.7412	7	16
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:11	ENHNNAKELL	0.787	0.7777	6	16
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B38:05	ENHNNAKELL	0.5693	0.9201	6	16
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:31	NHNNAKELLSL	0.9999	0.9335	7	18
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B38:05	NHNNAKELLSL	0.9996	0.9405	7	18
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B39:11	NHNNAKELLSL	0.9929	0.8418	7	18
MGA-RTF1	chr15	42021547	chr15	41730519	4024	HLA-B67:01	SPENHNNAKEL	0.9379	0.7245	4	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-B15:17	STSGLIQEL	0.9954	0.9208	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-B15:16	STSGLIQEL	0.9912	0.7434	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-A02:27	GLIQELLSL	0.9882	0.5175	9	18
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-A02:13	GLIQELLSL	0.9823	0.5992	9	18
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-A02:38	GLIQELLSL	0.9804	0.5866	9	18
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-A02:21	GLIQELLSL	0.9733	0.5494	9	18
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-A02:04	GLIQELLSL	0.9733	0.6141	9	18
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-A02:21	STSGLIQEL	0.9274	0.6484	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-A02:20	STSGLIQEL	0.9263	0.534	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-A32:13	STSGLIQEL	0.8144	0.9544	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-B13:01	STSGLIQEL	0.3262	0.9283	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-B13:02	GLIQELLSL	0.1134	0.5616	9	18
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-B13:01	GLIQELLSL	0.1006	0.9278	9	18
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-A02:38	SGLIQELLSL	0.5451	0.569	8	18
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C03:07	STSGLIQEL	0.9998	0.9663	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C15:04	STSGLIQEL	0.9997	0.8557	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C15:06	STSGLIQEL	0.9997	0.8938	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C03:19	STSGLIQEL	0.9996	0.9886	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C03:08	STSGLIQEL	0.9996	0.9385	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C04:06	STSGLIQEL	0.9992	0.8981	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C06:03	STSGLIQEL	0.9977	0.9855	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C12:04	STSGLIQEL	0.9976	0.9849	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C12:12	STSGLIQEL	0.997	0.8817	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C08:04	STSGLIQEL	0.9961	0.9286	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C08:13	STSGLIQEL	0.9961	0.9286	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C01:17	STSGLIQEL	0.9953	0.9537	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C12:16	STSGLIQEL	0.9742	0.9582	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C03:14	STSGLIQEL	0.9629	0.9685	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C08:03	STSGLIQEL	0.9608	0.9722	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C07:13	STSGLIQEL	0.9314	0.9533	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-B15:04	GLIQELLSL	0.927	0.7792	9	18
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C07:29	STSGLIQEL	0.9264	0.9569	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C01:30	STSGLIQEL	0.8989	0.9543	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C07:95	STSGLIQEL	0.8968	0.7365	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C07:19	STSGLIQEL	0.896	0.8124	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C02:06	STSGLIQEL	0.7663	0.9301	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C04:03	STSGLIQEL	0.9998	0.8646	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C15:09	STSGLIQEL	0.9997	0.8557	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C15:02	STSGLIQEL	0.9997	0.8468	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C15:05	STSGLIQEL	0.9997	0.9	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C03:04	STSGLIQEL	0.9996	0.9912	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C03:03	STSGLIQEL	0.9996	0.9912	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C03:17	STSGLIQEL	0.9993	0.9715	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C03:02	STSGLIQEL	0.9993	0.9648	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C03:67	STSGLIQEL	0.9992	0.9863	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C06:06	STSGLIQEL	0.9992	0.9846	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C03:05	STSGLIQEL	0.9992	0.9464	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C01:03	STSGLIQEL	0.9989	0.9014	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C04:04	STSGLIQEL	0.9988	0.8672	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C12:03	STSGLIQEL	0.9975	0.9689	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C01:02	STSGLIQEL	0.9966	0.9509	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C03:06	STSGLIQEL	0.9966	0.9909	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C16:02	STSGLIQEL	0.9951	0.9863	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C16:04	STSGLIQEL	0.9945	0.9761	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-A68:02	STSGLIQEL	0.9934	0.5347	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-B57:02	STSGLIQEL	0.9915	0.9118	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-A02:03	GLIQELLSL	0.9913	0.5813	9	18
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C12:02	STSGLIQEL	0.9908	0.9572	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C06:02	STSGLIQEL	0.9887	0.9834	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C06:17	STSGLIQEL	0.9887	0.9834	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-A69:01	STSGLIQEL	0.9863	0.6971	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C16:01	STSGLIQEL	0.9846	0.9746	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C07:04	STSGLIQEL	0.9822	0.9744	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-A25:01	STSGLIQEL	0.982	0.8114	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-A02:06	GLIQELLSL	0.9733	0.5494	9	18
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-A32:01	STSGLIQEL	0.9615	0.9345	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C08:01	STSGLIQEL	0.9608	0.9722	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-A02:14	STSGLIQEL	0.9344	0.5503	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-A02:06	STSGLIQEL	0.9274	0.6484	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C07:22	STSGLIQEL	0.9267	0.7327	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-B15:73	STSGLIQEL	0.9244	0.8926	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-B15:73	GLIQELLSL	0.9178	0.8864	9	18
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-B35:13	STSGLIQEL	0.8907	0.8584	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C07:01	STSGLIQEL	0.8852	0.7402	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-B15:30	STSGLIQEL	0.8756	0.695	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-B15:30	GLIQELLSL	0.8167	0.7742	9	18
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C17:01	STSGLIQEL	0.7944	0.877	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C06:08	STSGLIQEL	0.7502	0.9752	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C02:10	STSGLIQEL	0.6919	0.9481	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-C02:02	STSGLIQEL	0.6919	0.9481	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-B07:13	STSGLIQEL	0.3174	0.7976	6	15
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-A02:03	GLIQELLSLA	0.9964	0.5442	9	19
MGA-RTF1	chr15	42028896	chr15	41730519	4615	HLA-A68:02	STSGLIQELL	0.9344	0.5447	6	16

Top

Potential FusionNeoAntigen Information of MGA-RTF1 in HLA II

MGA-RTF1_42021547_41730519.msa
MGA-RTF1_42028896_41730519.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-0820	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-0828	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-0828	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1102	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1102	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1102	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1103	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1103	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1104	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1106	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1106	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1111	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1111	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1113	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1114	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1114	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1116	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1116	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1116	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1118	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1118	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1120	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1120	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1121	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1121	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1121	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1125	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1125	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1134	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1135	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1136	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1136	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1136	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1138	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1141	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1141	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1142	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1142	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1143	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1144	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1146	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1147	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1147	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1148	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1148	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1150	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1154	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1154	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1155	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1155	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1156	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1157	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1157	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1158	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1159	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1159	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1160	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1163	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1163	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1164	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1165	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1165	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1165	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1167	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1167	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1168	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1168	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1169	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1170	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1170	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1170	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1172	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1172	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1176	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1176	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1177	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1178	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1183	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1184	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1184	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1185	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1185	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1186	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1186	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1188	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1189	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1192	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1192	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1192	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1193	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1204	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1204	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1209	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1209	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1301	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1301	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1301	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1302	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1302	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1304	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1304	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1306	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1306	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1308	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1308	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1309	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1309	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1311	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1315	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1315	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1315	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1316	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1316	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1317	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1317	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1317	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1318	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1318	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1319	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1319	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1319	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1320	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1320	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1320	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1322	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1322	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1322	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1323	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1323	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1324	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1324	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1327	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1327	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1327	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1329	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1329	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1334	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1334	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1335	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1335	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1335	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1336	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1339	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1339	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1341	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1342	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1343	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1343	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1344	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1351	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1351	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1351	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1352	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1352	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1352	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1353	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1353	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1353	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1354	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1357	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1357	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1357	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1359	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1359	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1359	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1361	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1361	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1361	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1363	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1363	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1364	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1364	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1364	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1368	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1368	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1368	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1369	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1369	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1369	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1370	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1370	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1371	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1371	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1371	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1372	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1372	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1373	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1373	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1374	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1374	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1375	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1375	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1376	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1376	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1378	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1378	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1378	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1379	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1379	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1379	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1380	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1380	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1380	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1383	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1383	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1383	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1384	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1384	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1386	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1387	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1387	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1387	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1391	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1391	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1391	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1392	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1392	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1392	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1393	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1393	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1396	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1397	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1397	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1398	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1398	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1398	NNAKELLSLAKRKRS	9	24
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1399	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1399	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1403	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1406	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1412	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1412	NAKELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1416	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1417	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1420	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1421	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1429	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1437	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1440	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1477	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1478	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1481	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1483	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42021547	chr15	41730519	4024	DRB1-1484	AKELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-0820	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-0828	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1102	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1102	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1103	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1103	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1104	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1106	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1106	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1111	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1114	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1116	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1116	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1118	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1118	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1120	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1121	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1121	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1121	GLIQELLSLAKRKRS	9	24
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1125	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1135	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1136	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1136	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1138	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1141	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1141	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1142	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1142	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1143	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1144	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1146	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1147	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1147	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1148	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1148	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1150	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1154	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1155	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1155	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1156	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1157	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1157	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1158	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1159	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1159	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1160	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1163	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1163	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1165	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1165	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1167	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1168	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1170	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1170	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1172	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1172	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1176	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1176	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1177	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1178	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1184	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1185	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1185	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1186	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1186	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1188	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1189	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1192	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1192	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1204	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1204	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1209	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1209	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1301	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1301	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1302	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1304	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1306	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1306	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1308	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1308	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1309	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1311	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1315	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1315	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1315	GLIQELLSLAKRKRS	9	24
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1316	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1316	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1317	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1317	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1317	GLIQELLSLAKRKRS	9	24
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1318	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1319	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1319	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1319	GLIQELLSLAKRKRS	9	24
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1320	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1320	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1322	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1322	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1323	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1324	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1324	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1327	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1327	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1329	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1334	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1335	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1335	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1336	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1339	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1341	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1342	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1343	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1351	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1351	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1352	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1352	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1353	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1353	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1353	GLIQELLSLAKRKRS	9	24
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1354	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1357	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1357	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1357	GLIQELLSLAKRKRS	9	24
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1359	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1359	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1361	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1361	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1363	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1364	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1364	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1368	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1368	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1369	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1369	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1370	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1370	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1371	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1371	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1372	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1372	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1373	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1374	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1375	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1376	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1376	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1378	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1378	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1379	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1379	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1380	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1380	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1383	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1383	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1384	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1384	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1387	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1387	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1391	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1391	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1392	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1392	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1393	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1396	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1397	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1398	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1398	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1399	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1412	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1412	LIQELLSLAKRKRSD	10	25
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1429	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1437	IQELLSLAKRKRSDS	11	26
MGA-RTF1	chr15	42028896	chr15	41730519	4615	DRB1-1484	IQELLSLAKRKRSDS	11	26

Top

Fusion breakpoint peptide structures of MGA-RTF1

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
1979	ENHNNAKELLSLAK	MGA	RTF1	chr15	42021547	chr15	41730519	4024

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
9122	STSGLIQELLSLAK	MGA	RTF1	chr15	42028896	chr15	41730519	4615

Top

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of MGA-RTF1

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	1979	ENHNNAKELLSLAK	-7.9962	-8.1096
HLA-B14:02	3BVN	1979	ENHNNAKELLSLAK	-5.70842	-6.74372
HLA-B52:01	3W39	1979	ENHNNAKELLSLAK	-6.83737	-6.95077
HLA-B52:01	3W39	1979	ENHNNAKELLSLAK	-4.4836	-5.5189
HLA-A11:01	4UQ2	1979	ENHNNAKELLSLAK	-10.0067	-10.1201
HLA-A11:01	4UQ2	1979	ENHNNAKELLSLAK	-9.03915	-10.0745
HLA-A24:02	5HGA	1979	ENHNNAKELLSLAK	-6.56204	-6.67544
HLA-A24:02	5HGA	1979	ENHNNAKELLSLAK	-5.42271	-6.45801
HLA-B44:05	3DX8	1979	ENHNNAKELLSLAK	-7.85648	-8.89178
HLA-B44:05	3DX8	1979	ENHNNAKELLSLAK	-5.3978	-5.5112
HLA-A02:01	6TDR	1979	ENHNNAKELLSLAK	-3.37154	-4.40684
HLA-B14:02	3BVN	9122	STSGLIQELLSLAK	-7.15543	-7.26883
HLA-B14:02	3BVN	9122	STSGLIQELLSLAK	-4.77435	-5.80965
HLA-B52:01	3W39	9122	STSGLIQELLSLAK	-6.80875	-6.92215
HLA-B52:01	3W39	9122	STSGLIQELLSLAK	-4.20386	-5.23916
HLA-A11:01	4UQ2	9122	STSGLIQELLSLAK	-7.5194	-8.5547
HLA-A11:01	4UQ2	9122	STSGLIQELLSLAK	-6.9601	-7.0735
HLA-A24:02	5HGA	9122	STSGLIQELLSLAK	-7.52403	-7.63743
HLA-A24:02	5HGA	9122	STSGLIQELLSLAK	-5.82433	-6.85963
HLA-B27:05	6PYJ	9122	STSGLIQELLSLAK	-3.28285	-4.31815
HLA-B44:05	3DX8	9122	STSGLIQELLSLAK	-5.91172	-6.94702
HLA-B44:05	3DX8	9122	STSGLIQELLSLAK	-4.24346	-4.35686

Top

Vaccine Design for the FusionNeoAntigens of MGA-RTF1

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
MGA-RTF1	chr15	42021547	chr15	41730519	10	18	NAKELLSL	AATGCAAAGGAGCTCTTGTCCCTG
MGA-RTF1	chr15	42021547	chr15	41730519	10	19	NAKELLSLA	AATGCAAAGGAGCTCTTGTCCCTGGCA
MGA-RTF1	chr15	42021547	chr15	41730519	4	15	SPENHNNAKEL	AGCCCTGAGAACCATAATAATGCAAAGGAGCTC
MGA-RTF1	chr15	42021547	chr15	41730519	6	16	ENHNNAKELL	GAGAACCATAATAATGCAAAGGAGCTCTTG
MGA-RTF1	chr15	42021547	chr15	41730519	7	15	NHNNAKEL	AACCATAATAATGCAAAGGAGCTC
MGA-RTF1	chr15	42021547	chr15	41730519	7	16	NHNNAKELL	AACCATAATAATGCAAAGGAGCTCTTG
MGA-RTF1	chr15	42021547	chr15	41730519	7	18	NHNNAKELLSL	AACCATAATAATGCAAAGGAGCTCTTGTCCCTG
MGA-RTF1	chr15	42021547	chr15	41730519	9	18	NNAKELLSL	AATAATGCAAAGGAGCTCTTGTCCCTG
MGA-RTF1	chr15	42028896	chr15	41730519	6	15	STSGLIQEL	AGTACATCTGGGCTTATCCAGGAGCTC
MGA-RTF1	chr15	42028896	chr15	41730519	6	16	STSGLIQELL	AGTACATCTGGGCTTATCCAGGAGCTCTTG
MGA-RTF1	chr15	42028896	chr15	41730519	8	18	SGLIQELLSL	TCTGGGCTTATCCAGGAGCTCTTGTCCCTG
MGA-RTF1	chr15	42028896	chr15	41730519	9	18	GLIQELLSL	GGGCTTATCCAGGAGCTCTTGTCCCTG
MGA-RTF1	chr15	42028896	chr15	41730519	9	19	GLIQELLSLA	GGGCTTATCCAGGAGCTCTTGTCCCTGGCA

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
MGA-RTF1	chr15	42021547	chr15	41730519	10	25	NAKELLSLAKRKRSD	AATGCAAAGGAGCTCTTGTCCCTGGCAAAGCGAAAGCGCAGTGAC
MGA-RTF1	chr15	42021547	chr15	41730519	11	26	AKELLSLAKRKRSDS	GCAAAGGAGCTCTTGTCCCTGGCAAAGCGAAAGCGCAGTGACTCT
MGA-RTF1	chr15	42021547	chr15	41730519	9	24	NNAKELLSLAKRKRS	AATAATGCAAAGGAGCTCTTGTCCCTGGCAAAGCGAAAGCGCAGT
MGA-RTF1	chr15	42028896	chr15	41730519	10	25	LIQELLSLAKRKRSD	CTTATCCAGGAGCTCTTGTCCCTGGCAAAGCGAAAGCGCAGTGAC
MGA-RTF1	chr15	42028896	chr15	41730519	11	26	IQELLSLAKRKRSDS	ATCCAGGAGCTCTTGTCCCTGGCAAAGCGAAAGCGCAGTGACTCT
MGA-RTF1	chr15	42028896	chr15	41730519	9	24	GLIQELLSLAKRKRS	GGGCTTATCCAGGAGCTCTTGTCCCTGGCAAAGCGAAAGCGCAGT

Top

Information of the samples that have these potential fusion neoantigens of MGA-RTF1

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
OV	MGA-RTF1	chr15	42021547	ENST00000219905	chr15	41730519	ENST00000389629	TCGA-04-1337-01A
OV	MGA-RTF1	chr15	42028896	ENST00000219905	chr15	41730519	ENST00000389629	TCGA-04-1337-01A

Top

Potential target of CAR-T therapy development for MGA-RTF1

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

Top

Related Drugs to MGA-RTF1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to MGA-RTF1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)