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Fusion Protein:APBB1IP-DNAJC1 |
Fusion Gene and Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: APBB1IP-DNAJC1 | FusionPDB ID: 5345 | FusionGDB2.0 ID: 5345 | Hgene | Tgene | Gene symbol | APBB1IP | DNAJC1 | Gene ID | 54518 | 64215 |
Gene name | amyloid beta precursor protein binding family B member 1 interacting protein | DnaJ heat shock protein family (Hsp40) member C1 | |
Synonyms | INAG1|PREL1|RARP1|RIAM | DNAJL1|ERdj1|HTJ1|MTJ1 | |
Cytomap | 10p12.1 | 10p12.31 | |
Type of gene | protein-coding | protein-coding | |
Description | amyloid beta A4 precursor protein-binding family B member 1-interacting proteinAPBB1-interacting protein 1PREL-1RARP-1Rap1-GTP-interacting adaptor moleculeRap1-interacting adaptor moleculeproline rich EVH1 ligand 1proline-rich protein 73rap1-GTP-i | dnaJ homolog subfamily C member 1DnaJ (Hsp40) homolog, subfamily C, member 1DnaJ-like proteindnaJ protein homolog MTJ1 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q7Z5R6 Main function of 5'-partner protein: FUNCTION: Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}. | Q96DA6 Main function of 5'-partner protein: FUNCTION: Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling (By similarity). May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). {ECO:0000250|UniProtKB:Q07914, ECO:0000250|UniProtKB:Q9CQV7}. | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000376236, ENST00000356785, ENST00000493857, | ENST00000483085, ENST00000376946, ENST00000376980, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 3 X 3 X 3=27 | 12 X 9 X 6=648 |
# samples | 3 | 13 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(13/648*10)=-2.31748218985617 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Fusion gene context | PubMed: APBB1IP [Title/Abstract] AND DNAJC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Fusion neoantigen context | PubMed: APBB1IP [Title/Abstract] AND DNAJC1 [Title/Abstract] AND neoantigen [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | APBB1IP(26830621)-DNAJC1(22218070), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | APBB1IP-DNAJC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. APBB1IP-DNAJC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. APBB1IP-DNAJC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. APBB1IP-DNAJC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | DNAJC1 | GO:0050708 | regulation of protein secretion | 14668352 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:26830621/chr10:22218070) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Amino Acid Sequences |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000376236 | APBB1IP | chr10 | 26830621 | + | ENST00000376980 | DNAJC1 | chr10 | 22218070 | - | 3203 | 1610 | 455 | 3052 | 865 |
ENST00000376236 | APBB1IP | chr10 | 26830621 | + | ENST00000376946 | DNAJC1 | chr10 | 22218070 | - | 2066 | 1610 | 455 | 1717 | 420 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000376236 | ENST00000376980 | APBB1IP | chr10 | 26830621 | + | DNAJC1 | chr10 | 22218070 | - | 0.00163138 | 0.9983687 |
ENST00000376236 | ENST00000376946 | APBB1IP | chr10 | 26830621 | + | DNAJC1 | chr10 | 22218070 | - | 0.000483921 | 0.9995161 |
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Get the fusion protein sequences from here. |
Fusion protein sequence information is available in the fasta format. >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP |
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Fusion Protein Breakpoint Sequences for APBB1IP-DNAJC1 |
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Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Length(fusion protein) | BP in fusion protein | Peptide |
APBB1IP | chr10 | 26830621 | DNAJC1 | chr10 | 22218070 | 1610 | 383 | KMKYKAPTDYCFVLKDASSADIRKAY |
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Potential FusionNeoAntigen Information of APBB1IP-DNAJC1 in HLA I |
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APBB1IP-DNAJC1_26830621_22218070.msa |
![]() * We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5) |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA I | FusionNeoAntigen peptide | Binding score | Immunogenic score | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
APBB1IP-DNAJC1 | chr10 | 26830621 | chr10 | 22218070 | 1610 | HLA-B35:03 | APTDYCFVL | 0.9554 | 0.9144 | 5 | 14 |
APBB1IP-DNAJC1 | chr10 | 26830621 | chr10 | 22218070 | 1610 | HLA-B35:02 | APTDYCFVL | 0.8974 | 0.9472 | 5 | 14 |
APBB1IP-DNAJC1 | chr10 | 26830621 | chr10 | 22218070 | 1610 | HLA-B35:04 | APTDYCFVL | 0.8974 | 0.9472 | 5 | 14 |
APBB1IP-DNAJC1 | chr10 | 26830621 | chr10 | 22218070 | 1610 | HLA-B81:01 | APTDYCFVL | 0.3567 | 0.6045 | 5 | 14 |
APBB1IP-DNAJC1 | chr10 | 26830621 | chr10 | 22218070 | 1610 | HLA-B07:12 | APTDYCFVL | 0.9428 | 0.7503 | 5 | 14 |
APBB1IP-DNAJC1 | chr10 | 26830621 | chr10 | 22218070 | 1610 | HLA-B35:12 | APTDYCFVL | 0.8974 | 0.9472 | 5 | 14 |
APBB1IP-DNAJC1 | chr10 | 26830621 | chr10 | 22218070 | 1610 | HLA-B39:10 | APTDYCFVL | 0.8669 | 0.9587 | 5 | 14 |
APBB1IP-DNAJC1 | chr10 | 26830621 | chr10 | 22218070 | 1610 | HLA-B42:02 | APTDYCFVL | 0.4384 | 0.8578 | 5 | 14 |
APBB1IP-DNAJC1 | chr10 | 26830621 | chr10 | 22218070 | 1610 | HLA-B42:01 | APTDYCFVL | 0.4049 | 0.855 | 5 | 14 |
APBB1IP-DNAJC1 | chr10 | 26830621 | chr10 | 22218070 | 1610 | HLA-B55:04 | APTDYCFVL | 0.9507 | 0.5084 | 5 | 14 |
APBB1IP-DNAJC1 | chr10 | 26830621 | chr10 | 22218070 | 1610 | HLA-B35:13 | APTDYCFVL | 0.9416 | 0.9206 | 5 | 14 |
APBB1IP-DNAJC1 | chr10 | 26830621 | chr10 | 22218070 | 1610 | HLA-B35:09 | APTDYCFVL | 0.8974 | 0.9472 | 5 | 14 |
APBB1IP-DNAJC1 | chr10 | 26830621 | chr10 | 22218070 | 1610 | HLA-B67:01 | APTDYCFVL | 0.8633 | 0.7721 | 5 | 14 |
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Potential FusionNeoAntigen Information of APBB1IP-DNAJC1 in HLA II |
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![]() * We used NetMHCIIpan v4.1 (%rank<0.5). |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA II | FusionNeoAntigen peptide | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
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Fusion breakpoint peptide structures of APBB1IP-DNAJC1 |
![]() * The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA. |
File name | BPseq | Hgene | Tgene | Hchr | Hbp | Tchr | Tbp | AAlen |
7036 | PTDYCFVLKDASSA | APBB1IP | DNAJC1 | chr10 | 26830621 | chr10 | 22218070 | 1610 |
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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of APBB1IP-DNAJC1 |
![]() * We used Glide to predict the interaction between HLAs and neoantigens. |
HLA allele | PDB ID | File name | BPseq | Docking score | Glide score |
HLA-B14:02 | 3BVN | 7036 | PTDYCFVLKDASSA | -8.24654 | -8.35834 |
HLA-B14:02 | 3BVN | 7036 | PTDYCFVLKDASSA | -4.37148 | -5.41458 |
HLA-B52:01 | 3W39 | 7036 | PTDYCFVLKDASSA | -7.30613 | -7.41793 |
HLA-B52:01 | 3W39 | 7036 | PTDYCFVLKDASSA | -3.8424 | -4.8855 |
HLA-A11:01 | 4UQ2 | 7036 | PTDYCFVLKDASSA | -7.68219 | -7.79399 |
HLA-A24:02 | 5HGA | 7036 | PTDYCFVLKDASSA | -10.4053 | -10.5171 |
HLA-A24:02 | 5HGA | 7036 | PTDYCFVLKDASSA | -5.10207 | -6.14517 |
HLA-B44:05 | 3DX8 | 7036 | PTDYCFVLKDASSA | -6.19253 | -6.30433 |
HLA-B44:05 | 3DX8 | 7036 | PTDYCFVLKDASSA | -6.12534 | -7.16844 |
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Vaccine Design for the FusionNeoAntigens of APBB1IP-DNAJC1 |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide sequence | FusionNeoAntigen RNA sequence |
APBB1IP-DNAJC1 | chr10 | 26830621 | chr10 | 22218070 | 5 | 14 | APTDYCFVL | ACTGACTATTGCTTTGTTTTAAAGGAT |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide | FusionNEoAntigen RNA sequence |
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Information of the samples that have these potential fusion neoantigens of APBB1IP-DNAJC1 |
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Cancer type | Fusion gene | Hchr | Hbp | Henst | Tchr | Tbp | Tenst | Sample |
SKCM | APBB1IP-DNAJC1 | chr10 | 26830621 | ENST00000376236 | chr10 | 22218070 | ENST00000376946 | TCGA-ER-A196-01A |
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Potential target of CAR-T therapy development for APBB1IP-DNAJC1 |
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![]() * Minus value of BPloci means that the break point is located before the CDS. |
- In-frame and retained 'Transmembrane'. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | DNAJC1 | chr10:26830621 | chr10:22218070 | ENST00000376980 | 0 | 12 | 154_174 | 0 | 555.0 | Transmembrane | Helical |
![]() * We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image. |
Hgene | Hchr | Hbp | Henst | Tgene | Tchr | Tbp | Tenst | DeepLoc result |
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Related Drugs to APBB1IP-DNAJC1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to APBB1IP-DNAJC1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |