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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:MPP5-RAD51B

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MPP5-RAD51B
FusionPDB ID: 54749
FusionGDB2.0 ID: 54749
HgeneTgene
Gene symbol

MPP5

RAD51B

Gene ID

64398

5890

Gene namemembrane palmitoylated protein 5RAD51 paralog B
SynonymsPALS1R51H2|RAD51L1|REC2
Cytomap

14q23.3

14q24.1

Type of geneprotein-codingprotein-coding
DescriptionMAGUK p55 subfamily member 5membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)protein associated with Lin-7 1protein associated with lin seven 1stardustDNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein
Modification date2020031320200313
UniProtAcc

Q8N3R9

Main function of 5'-partner protein: FUNCTION: Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:16678097, PubMed:25385611). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (PubMed:27466317). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). Plays a role in the T-cell receptor-mediated activation of NF-kappa-B (PubMed:21479189). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). {ECO:0000250|UniProtKB:B4F7E7, ECO:0000250|UniProtKB:Q9JLB2, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21479189, ECO:0000269|PubMed:25385611, ECO:0000269|PubMed:27466317}.; FUNCTION: (Microbial infection) Acts as an interaction partner for human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity. {ECO:0000269|PubMed:20861307, ECO:0000303|PubMed:32891874}.

O15315

Main function of 5'-partner protein: FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. {ECO:0000269|PubMed:11751635, ECO:0000269|PubMed:11751636, ECO:0000269|PubMed:11842113, ECO:0000269|PubMed:12441335, ECO:0000269|PubMed:23108668, ECO:0000269|PubMed:23149936}.
Ensembl transtripts involved in fusion geneENST idsENST00000261681, ENST00000555925, 
ENST00000554911, ENST00000556345, 
ENST00000469165, ENST00000488612, 
ENST00000390683, ENST00000471583, 
ENST00000487270, ENST00000487861, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 10 X 12=96041 X 23 X 12=11316
# samples 2356
** MAII scorelog2(23/960*10)=-2.06140054466414
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(56/11316*10)=-4.33679344445129
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: MPP5 [Title/Abstract] AND RAD51B [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: MPP5 [Title/Abstract] AND RAD51B [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MPP5(67779427)-RAD51B(69196525), # samples:2
RAD51B(68353921)-MPP5(67770238), # samples:2
Anticipated loss of major functional domain due to fusion event.MPP5-RAD51B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MPP5-RAD51B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MPP5-RAD51B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MPP5-RAD51B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RAD51B-MPP5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RAD51B-MPP5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:67779427/chr14:69196525)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across MPP5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAD51B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261681MPP5chr1467784196+ENST00000487861RAD51Bchr1468878140+277320306612454597
ENST00000261681MPP5chr1467784196+ENST00000471583RAD51Bchr1468878140+266520306612229522
ENST00000261681MPP5chr1467784196+ENST00000487270RAD51Bchr1468878140+372520306612331556
ENST00000261681MPP5chr1467784196+ENST00000488612RAD51Bchr1468878140+270020306612277538
ENST00000261681MPP5chr1467784196+ENST00000390683RAD51Bchr1468878140+227820306612277539
ENST00000555925MPP5chr1467784196+ENST00000487861RAD51Bchr1468878140+222714842171908563
ENST00000555925MPP5chr1467784196+ENST00000471583RAD51Bchr1468878140+211914842171683488
ENST00000555925MPP5chr1467784196+ENST00000487270RAD51Bchr1468878140+317914842171785522
ENST00000555925MPP5chr1467784196+ENST00000488612RAD51Bchr1468878140+215414842171731504
ENST00000555925MPP5chr1467784196+ENST00000390683RAD51Bchr1468878140+173214842171731505
ENST00000261681MPP5chr1467784196+ENST00000487861RAD51Bchr1468878141+277320306612454597
ENST00000261681MPP5chr1467784196+ENST00000471583RAD51Bchr1468878141+266520306612229522
ENST00000261681MPP5chr1467784196+ENST00000487270RAD51Bchr1468878141+372520306612331556
ENST00000261681MPP5chr1467784196+ENST00000488612RAD51Bchr1468878141+270020306612277538
ENST00000261681MPP5chr1467784196+ENST00000390683RAD51Bchr1468878141+227820306612277539
ENST00000555925MPP5chr1467784196+ENST00000487861RAD51Bchr1468878141+222714842171908563
ENST00000555925MPP5chr1467784196+ENST00000471583RAD51Bchr1468878141+211914842171683488
ENST00000555925MPP5chr1467784196+ENST00000487270RAD51Bchr1468878141+317914842171785522
ENST00000555925MPP5chr1467784196+ENST00000488612RAD51Bchr1468878141+215414842171731504
ENST00000555925MPP5chr1467784196+ENST00000390683RAD51Bchr1468878141+173214842171731505

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261681ENST00000487861MPP5chr1467784196+RAD51Bchr1468878140+0.001289160.9987109
ENST00000261681ENST00000471583MPP5chr1467784196+RAD51Bchr1468878140+0.0006854640.99931455
ENST00000261681ENST00000487270MPP5chr1467784196+RAD51Bchr1468878140+0.0006537790.9993462
ENST00000261681ENST00000488612MPP5chr1467784196+RAD51Bchr1468878140+0.0009059980.999094
ENST00000261681ENST00000390683MPP5chr1467784196+RAD51Bchr1468878140+0.0008432770.9991567
ENST00000555925ENST00000487861MPP5chr1467784196+RAD51Bchr1468878140+0.0012873430.99871266
ENST00000555925ENST00000471583MPP5chr1467784196+RAD51Bchr1468878140+0.0004440050.999556
ENST00000555925ENST00000487270MPP5chr1467784196+RAD51Bchr1468878140+0.0004591720.9995408
ENST00000555925ENST00000488612MPP5chr1467784196+RAD51Bchr1468878140+0.0006238460.99937624
ENST00000555925ENST00000390683MPP5chr1467784196+RAD51Bchr1468878140+0.0005959260.9994041
ENST00000261681ENST00000487861MPP5chr1467784196+RAD51Bchr1468878141+0.001289160.9987109
ENST00000261681ENST00000471583MPP5chr1467784196+RAD51Bchr1468878141+0.0006854640.99931455
ENST00000261681ENST00000487270MPP5chr1467784196+RAD51Bchr1468878141+0.0006537790.9993462
ENST00000261681ENST00000488612MPP5chr1467784196+RAD51Bchr1468878141+0.0009059980.999094
ENST00000261681ENST00000390683MPP5chr1467784196+RAD51Bchr1468878141+0.0008432770.9991567
ENST00000555925ENST00000487861MPP5chr1467784196+RAD51Bchr1468878141+0.0012873430.99871266
ENST00000555925ENST00000471583MPP5chr1467784196+RAD51Bchr1468878141+0.0004440050.999556
ENST00000555925ENST00000487270MPP5chr1467784196+RAD51Bchr1468878141+0.0004591720.9995408
ENST00000555925ENST00000488612MPP5chr1467784196+RAD51Bchr1468878141+0.0006238460.99937624
ENST00000555925ENST00000390683MPP5chr1467784196+RAD51Bchr1468878141+0.0005959260.9994041

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for MPP5-RAD51B

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
MPP5chr1467784196RAD51Bchr14688781401484422KRKKVLYNANKNDGTSGSSCVIAALG
MPP5chr1467784196RAD51Bchr14688781402030456KRKKVLYNANKNDGTSGSSCVIAALG
MPP5chr1467784196RAD51Bchr14688781411484422KRKKVLYNANKNDGTSGSSCVIAALG
MPP5chr1467784196RAD51Bchr14688781412030456KRKKVLYNANKNDGTSGSSCVIAALG

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Potential FusionNeoAntigen Information of MPP5-RAD51B in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Potential FusionNeoAntigen Information of MPP5-RAD51B in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
MPP5-RAD51B_67784196_68878140.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
MPP5-RAD51Bchr1467784196chr14688781402030DRB1-0434KVLYNANKNDGTSGS318
MPP5-RAD51Bchr1467784196chr14688781402030DRB1-1183KKVLYNANKNDGTSG217
MPP5-RAD51Bchr1467784196chr14688781402030DRB1-1367RKKVLYNANKNDGTS116
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0201RKKVLYNANKNDGTS116
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0202KVLYNANKNDGTSGS318
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0202KKVLYNANKNDGTSG217
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0202RKKVLYNANKNDGTS116
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0204RKKVLYNANKNDGTS116
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0204KRKKVLYNANKNDGT015
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0205KVLYNANKNDGTSGS318
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0205KKVLYNANKNDGTSG217
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0205RKKVLYNANKNDGTS116
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0209KVLYNANKNDGTSGS318
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0209KKVLYNANKNDGTSG217
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0210KVLYNANKNDGTSGS318
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0210KKVLYNANKNDGTSG217
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0210RKKVLYNANKNDGTS116
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0211KVLYNANKNDGTSGS318
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0211KKVLYNANKNDGTSG217
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0211RKKVLYNANKNDGTS116
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0212KVLYNANKNDGTSGS318
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0212KKVLYNANKNDGTSG217
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0212RKKVLYNANKNDGTS116
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0213KVLYNANKNDGTSGS318
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0213KKVLYNANKNDGTSG217
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0213RKKVLYNANKNDGTS116
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0214RKKVLYNANKNDGTS116
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0214KVLYNANKNDGTSGS318
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0214KKVLYNANKNDGTSG217
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0215KVLYNANKNDGTSGS318
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0215KKVLYNANKNDGTSG217
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0215RKKVLYNANKNDGTS116
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0216RKKVLYNANKNDGTS116
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0216KVLYNANKNDGTSGS318
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0216KKVLYNANKNDGTSG217
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0217KVLYNANKNDGTSGS318
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0217KKVLYNANKNDGTSG217
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0217RKKVLYNANKNDGTS116
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0218KVLYNANKNDGTSGS318
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0218KKVLYNANKNDGTSG217
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0218RKKVLYNANKNDGTS116
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0219KVLYNANKNDGTSGS318
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0219KKVLYNANKNDGTSG217
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0219RKKVLYNANKNDGTS116
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0220KVLYNANKNDGTSGS318
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0220KKVLYNANKNDGTSG217
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0220RKKVLYNANKNDGTS116
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0221KVLYNANKNDGTSGS318
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0221KKVLYNANKNDGTSG217
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0222KVLYNANKNDGTSGS318
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0222KKVLYNANKNDGTSG217
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0222RKKVLYNANKNDGTS116
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0223KVLYNANKNDGTSGS318
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0223KKVLYNANKNDGTSG217
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0223RKKVLYNANKNDGTS116
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0224RKKVLYNANKNDGTS116
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0225KVLYNANKNDGTSGS318
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0225KKVLYNANKNDGTSG217
MPP5-RAD51Bchr1467784196chr14688781402030DRB3-0225RKKVLYNANKNDGTS116

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Fusion breakpoint peptide structures of MPP5-RAD51B

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of MPP5-RAD51B

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score

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Vaccine Design for the FusionNeoAntigens of MPP5-RAD51B

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
MPP5-RAD51Bchr1467784196chr1468878140015KRKKVLYNANKNDGTAGAGGAAAAAGGTTTTATATAATGCCAATAAAAATGATGGCACTT
MPP5-RAD51Bchr1467784196chr1468878140116RKKVLYNANKNDGTSGGAAAAAGGTTTTATATAATGCCAATAAAAATGATGGCACTTCTG
MPP5-RAD51Bchr1467784196chr1468878140217KKVLYNANKNDGTSGAAAAGGTTTTATATAATGCCAATAAAAATGATGGCACTTCTGGAT
MPP5-RAD51Bchr1467784196chr1468878140318KVLYNANKNDGTSGSAGGTTTTATATAATGCCAATAAAAATGATGGCACTTCTGGATCCA

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Information of the samples that have these potential fusion neoantigens of MPP5-RAD51B

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample

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Potential target of CAR-T therapy development for MPP5-RAD51B

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to MPP5-RAD51B

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MPP5-RAD51B

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRAD51BC0006142Malignant neoplasm of breast1CTD_human
TgeneRAD51BC0013146Drug abuse1CTD_human
TgeneRAD51BC0013170Drug habituation1CTD_human
TgeneRAD51BC0013222Drug Use Disorders1CTD_human
TgeneRAD51BC0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneRAD51BC0038580Substance Dependence1CTD_human
TgeneRAD51BC0038586Substance Use Disorders1CTD_human
TgeneRAD51BC0236969Substance-Related Disorders1CTD_human
TgeneRAD51BC0238033Carcinoma of Male Breast1CTD_human
TgeneRAD51BC0242788Breast Neoplasms, Male1CTD_human
TgeneRAD51BC0678222Breast Carcinoma1CTD_human
TgeneRAD51BC0740858Substance abuse problem1CTD_human
TgeneRAD51BC1257931Mammary Neoplasms, Human1CTD_human
TgeneRAD51BC1458155Mammary Neoplasms1CTD_human
TgeneRAD51BC1510472Drug Dependence1CTD_human
TgeneRAD51BC4316881Prescription Drug Abuse1CTD_human
TgeneRAD51BC4704874Mammary Carcinoma, Human1CTD_human