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Fusion Protein:NCOR2-SCARB1

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: NCOR2-SCARB1
	FusionPDB ID: 57887
	FusionGDB2.0 ID: 57887
		Hgene	Tgene
	Gene symbol	NCOR2	SCARB1
	Gene ID	9612	949
	Gene name	nuclear receptor corepressor 2	scavenger receptor class B member 1
	Synonyms	CTG26\|N-CoR2\|SMAP270\|SMRT\|SMRTE\|SMRTE-tau\|TNRC14\|TRAC\|TRAC-1\|TRAC1	CD36L1\|CLA-1\|CLA1\|HDLQTL6\|SR-BI\|SRB1
	Cytomap	12q24.31	12q24.31
	Type of gene	protein-coding	protein-coding
	Description	nuclear receptor corepressor 2CTG repeat protein 26T3 receptor-associating factorsilencing mediator for retinoid and thyroid hormone receptorsthyroid-, retinoic-acid-receptor-associated corepressor	scavenger receptor class B member 1CD36 and LIMPII analogous 1CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1scavenger receptor class B type III
	Modification date	20200313	20200313
	UniProtAcc	Q9Y618 Main function of 5'-partner protein: FUNCTION: Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). {ECO:0000269\|PubMed:18212045, ECO:0000269\|PubMed:20812024, ECO:0000269\|PubMed:23911289}.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000356219, ENST00000397355, ENST00000404121, ENST00000404621, ENST00000405201, ENST00000429285,	ENST00000261693, ENST00000376788, ENST00000546215, ENST00000535005, ENST00000540495, ENST00000541205, ENST00000544327, ENST00000339570, ENST00000415380,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	35 X 38 X 19=25270	6 X 11 X 10=660
	# samples	51	18
	** MAII score	log2(51/25270*10)=-5.63078460697328 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/660*10)=-1.87446911791614 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: NCOR2 [Title/Abstract] AND SCARB1 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: NCOR2 [Title/Abstract] AND SCARB1 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	NCOR2(125051854)-SCARB1(125302253), # samples:7
Anticipated loss of major functional domain due to fusion event.	NCOR2-SCARB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NCOR2-SCARB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NCOR2-SCARB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NCOR2-SCARB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NCOR2-SCARB1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. NCOR2-SCARB1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. NCOR2-SCARB1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. NCOR2-SCARB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. NCOR2-SCARB1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SCARB1	GO:0010886	positive regulation of cholesterol storage	9211901
Tgene	SCARB1	GO:0015920	lipopolysaccharide transport	12651854
Tgene	SCARB1	GO:0032497	detection of lipopolysaccharide	12651854
Tgene	SCARB1	GO:0034384	high-density lipoprotein particle clearance	9211901
Tgene	SCARB1	GO:0043654	recognition of apoptotic cell	9211901
Tgene	SCARB1	GO:0051000	positive regulation of nitric-oxide synthase activity	11792700

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:125051854/chr12:125302253)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across NCOR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SCARB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000405201	NCOR2	chr12	124882665	-	ENST00000339570	SCARB1	chr12	125263132	-	3608	1877	1	1884	627
ENST00000405201	NCOR2	chr12	124882665	-	ENST00000415380	SCARB1	chr12	125263132	-	2831	1877	1	1884	627
ENST00000405201	NCOR2	chr12	124904503	-	ENST00000339570	SCARB1	chr12	125302253	-	4489	1483	1	2877	958
ENST00000405201	NCOR2	chr12	124904503	-	ENST00000415380	SCARB1	chr12	125302253	-	3962	1483	1	3015	1004
ENST00000405201	NCOR2	chr12	124904503	-	ENST00000261693	SCARB1	chr12	125302253	-	3841	1483	1	2886	961
ENST00000405201	NCOR2	chr12	124907047	-	ENST00000339570	SCARB1	chr12	125279814	-	3388	1384	1	1776	591
ENST00000405201	NCOR2	chr12	124907047	-	ENST00000415380	SCARB1	chr12	125279814	-	2861	1384	1	1914	637
ENST00000405201	NCOR2	chr12	124907047	-	ENST00000261693	SCARB1	chr12	125279814	-	2740	1384	1	1785	594
ENST00000405201	NCOR2	chr12	124907047	-	ENST00000376788	SCARB1	chr12	125279814	-	2733	1384	1	1785	594
ENST00000405201	NCOR2	chr12	124907047	-	ENST00000546215	SCARB1	chr12	125279814	-	1790	1384	1	1701	566
ENST00000404621	NCOR2	chr12	124968142	-	ENST00000339570	SCARB1	chr12	125263132	-	2298	567	117	686	189
ENST00000404621	NCOR2	chr12	124968142	-	ENST00000415380	SCARB1	chr12	125263132	-	1521	567	117	686	189
ENST00000356219	NCOR2	chr12	124968142	-	ENST00000339570	SCARB1	chr12	125263132	-	2298	567	117	686	189
ENST00000356219	NCOR2	chr12	124968142	-	ENST00000415380	SCARB1	chr12	125263132	-	1521	567	117	686	189
ENST00000397355	NCOR2	chr12	124968142	-	ENST00000339570	SCARB1	chr12	125263132	-	2298	567	117	686	189
ENST00000397355	NCOR2	chr12	124968142	-	ENST00000415380	SCARB1	chr12	125263132	-	1521	567	117	686	189
ENST00000429285	NCOR2	chr12	124968142	-	ENST00000339570	SCARB1	chr12	125263132	-	2298	567	117	686	189
ENST00000429285	NCOR2	chr12	124968142	-	ENST00000415380	SCARB1	chr12	125263132	-	1521	567	117	686	189
ENST00000404621	NCOR2	chr12	124934361	-	ENST00000339570	SCARB1	chr12	125302253	-	3977	971	995	2365	456
ENST00000404621	NCOR2	chr12	124934361	-	ENST00000415380	SCARB1	chr12	125302253	-	3450	971	995	2503	502
ENST00000404621	NCOR2	chr12	124934361	-	ENST00000261693	SCARB1	chr12	125302253	-	3329	971	995	2374	459
ENST00000356219	NCOR2	chr12	124934361	-	ENST00000339570	SCARB1	chr12	125302253	-	3977	971	995	2365	456
ENST00000356219	NCOR2	chr12	124934361	-	ENST00000415380	SCARB1	chr12	125302253	-	3450	971	995	2503	502
ENST00000356219	NCOR2	chr12	124934361	-	ENST00000261693	SCARB1	chr12	125302253	-	3329	971	995	2374	459
ENST00000397355	NCOR2	chr12	124934361	-	ENST00000339570	SCARB1	chr12	125302253	-	3977	971	995	2365	456
ENST00000397355	NCOR2	chr12	124934361	-	ENST00000415380	SCARB1	chr12	125302253	-	3450	971	995	2503	502
ENST00000397355	NCOR2	chr12	124934361	-	ENST00000261693	SCARB1	chr12	125302253	-	3329	971	995	2374	459
ENST00000429285	NCOR2	chr12	124934361	-	ENST00000339570	SCARB1	chr12	125302253	-	3977	971	995	2365	456
ENST00000429285	NCOR2	chr12	124934361	-	ENST00000415380	SCARB1	chr12	125302253	-	3450	971	995	2503	502
ENST00000429285	NCOR2	chr12	124934361	-	ENST00000261693	SCARB1	chr12	125302253	-	3329	971	995	2374	459
ENST00000405201	NCOR2	chr12	124979693	-	ENST00000339570	SCARB1	chr12	125302253	-	3112	106	1	1500	499
ENST00000405201	NCOR2	chr12	124979693	-	ENST00000415380	SCARB1	chr12	125302253	-	2585	106	1	1638	545
ENST00000405201	NCOR2	chr12	124979693	-	ENST00000261693	SCARB1	chr12	125302253	-	2464	106	1	1509	502
ENST00000405201	NCOR2	chr12	124914159	-	ENST00000339570	SCARB1	chr12	125279814	-	3154	1150	1	1542	513
ENST00000405201	NCOR2	chr12	124914159	-	ENST00000415380	SCARB1	chr12	125279814	-	2627	1150	1	1680	559
ENST00000405201	NCOR2	chr12	124914159	-	ENST00000261693	SCARB1	chr12	125279814	-	2506	1150	1	1551	516
ENST00000405201	NCOR2	chr12	124914159	-	ENST00000376788	SCARB1	chr12	125279814	-	2499	1150	1	1551	516
ENST00000405201	NCOR2	chr12	124914159	-	ENST00000546215	SCARB1	chr12	125279814	-	1556	1150	1	1467	488
ENST00000405201	NCOR2	chr12	124882664	-	ENST00000339570	SCARB1	chr12	125263131	-	3608	1877	1	1884	627
ENST00000405201	NCOR2	chr12	124882664	-	ENST00000415380	SCARB1	chr12	125263131	-	2831	1877	1	1884	627

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000405201	ENST00000339570	NCOR2	chr12	124882665	-	SCARB1	chr12	125263132	-	0.015265349	0.98473465
ENST00000405201	ENST00000415380	NCOR2	chr12	124882665	-	SCARB1	chr12	125263132	-	0.02711094	0.9728891
ENST00000405201	ENST00000339570	NCOR2	chr12	124904503	-	SCARB1	chr12	125302253	-	0.002644908	0.9973551
ENST00000405201	ENST00000415380	NCOR2	chr12	124904503	-	SCARB1	chr12	125302253	-	0.00552721	0.9944728
ENST00000405201	ENST00000261693	NCOR2	chr12	124904503	-	SCARB1	chr12	125302253	-	0.004696742	0.9953033
ENST00000405201	ENST00000339570	NCOR2	chr12	124907047	-	SCARB1	chr12	125279814	-	0.008999375	0.9910006
ENST00000405201	ENST00000415380	NCOR2	chr12	124907047	-	SCARB1	chr12	125279814	-	0.026508708	0.9734914
ENST00000405201	ENST00000261693	NCOR2	chr12	124907047	-	SCARB1	chr12	125279814	-	0.016548147	0.98345184
ENST00000405201	ENST00000376788	NCOR2	chr12	124907047	-	SCARB1	chr12	125279814	-	0.017398493	0.9826015
ENST00000405201	ENST00000546215	NCOR2	chr12	124907047	-	SCARB1	chr12	125279814	-	0.027581917	0.97241807
ENST00000404621	ENST00000339570	NCOR2	chr12	124934361	-	SCARB1	chr12	125302253	-	0.006119524	0.9938805
ENST00000404621	ENST00000415380	NCOR2	chr12	124934361	-	SCARB1	chr12	125302253	-	0.02692662	0.9730734
ENST00000404621	ENST00000261693	NCOR2	chr12	124934361	-	SCARB1	chr12	125302253	-	0.012562583	0.9874374
ENST00000356219	ENST00000339570	NCOR2	chr12	124934361	-	SCARB1	chr12	125302253	-	0.006119524	0.9938805
ENST00000356219	ENST00000415380	NCOR2	chr12	124934361	-	SCARB1	chr12	125302253	-	0.02692662	0.9730734
ENST00000356219	ENST00000261693	NCOR2	chr12	124934361	-	SCARB1	chr12	125302253	-	0.012562583	0.9874374
ENST00000397355	ENST00000339570	NCOR2	chr12	124934361	-	SCARB1	chr12	125302253	-	0.006119524	0.9938805
ENST00000397355	ENST00000415380	NCOR2	chr12	124934361	-	SCARB1	chr12	125302253	-	0.02692662	0.9730734
ENST00000397355	ENST00000261693	NCOR2	chr12	124934361	-	SCARB1	chr12	125302253	-	0.012562583	0.9874374
ENST00000429285	ENST00000339570	NCOR2	chr12	124934361	-	SCARB1	chr12	125302253	-	0.006119524	0.9938805
ENST00000429285	ENST00000415380	NCOR2	chr12	124934361	-	SCARB1	chr12	125302253	-	0.02692662	0.9730734
ENST00000429285	ENST00000261693	NCOR2	chr12	124934361	-	SCARB1	chr12	125302253	-	0.012562583	0.9874374
ENST00000405201	ENST00000339570	NCOR2	chr12	124979693	-	SCARB1	chr12	125302253	-	0.002787164	0.9972128
ENST00000405201	ENST00000415380	NCOR2	chr12	124979693	-	SCARB1	chr12	125302253	-	0.019389762	0.98061025
ENST00000405201	ENST00000261693	NCOR2	chr12	124979693	-	SCARB1	chr12	125302253	-	0.005925868	0.99407417
ENST00000405201	ENST00000339570	NCOR2	chr12	124914159	-	SCARB1	chr12	125279814	-	0.007931149	0.9920689
ENST00000405201	ENST00000415380	NCOR2	chr12	124914159	-	SCARB1	chr12	125279814	-	0.034257267	0.9657427
ENST00000405201	ENST00000261693	NCOR2	chr12	124914159	-	SCARB1	chr12	125279814	-	0.014760146	0.98523986
ENST00000405201	ENST00000376788	NCOR2	chr12	124914159	-	SCARB1	chr12	125279814	-	0.015560702	0.9844393
ENST00000405201	ENST00000546215	NCOR2	chr12	124914159	-	SCARB1	chr12	125279814	-	0.026394442	0.9736056
ENST00000405201	ENST00000339570	NCOR2	chr12	124882664	-	SCARB1	chr12	125263131	-	0.015265349	0.98473465
ENST00000405201	ENST00000415380	NCOR2	chr12	124882664	-	SCARB1	chr12	125263131	-	0.02711094	0.9728891

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for NCOR2-SCARB1

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
NCOR2	chr12	124904503	SCARB1	chr12	125302253	1483	493	SLVRRSYRRRGKSQNVRIDPSSLSFN
NCOR2	chr12	124907047	SCARB1	chr12	125279814	1384	461	KNFGLIASFLERKVTGIPMNCSVKLQ
NCOR2	chr12	124914159	SCARB1	chr12	125279814	1150	383	EVSEIIDGLSEQEVTGIPMNCSVKLQ
NCOR2	chr12	124968142	SCARB1	chr12	125263132	567	150	ATGQPAGSEDLTKGPEDTVSQPGLAA
NCOR2	chr12	124979693	SCARB1	chr12	125302253	106	35	SLSYPVQIARTHTNVRIDPSSLSFNM

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Potential FusionNeoAntigen Information of NCOR2-SCARB1 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

NCOR2-SCARB1_124904503_125302253.msa
NCOR2-SCARB1_124907047_125279814.msa
NCOR2-SCARB1_124914159_125279814.msa
NCOR2-SCARB1_124979693_125302253.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	HLA-B27:05	RRGKSQNVR	0.9969	0.5483	8	17
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	HLA-C07:05	RRRGKSQNV	0.8791	0.934	7	16
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	HLA-B27:10	RRGKSQNVR	0.9952	0.7126	8	17
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	HLA-B27:10	RRRGKSQNV	0.9928	0.5587	7	16
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	HLA-C06:08	RRRGKSQNV	0.7966	0.9833	7	16
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	HLA-C07:01	RRRGKSQNV	0.6924	0.5665	7	16
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	HLA-C07:22	RRRGKSQNV	0.3827	0.6336	7	16
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	HLA-C06:17	RRRGKSQNV	0.088	0.9874	7	16
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	HLA-C06:02	RRRGKSQNV	0.088	0.9874	7	16
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	HLA-B15:73	SQNVRIDPSSL	0.9981	0.9576	12	23
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	HLA-B15:30	SQNVRIDPSSL	0.9971	0.95	12	23
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	HLA-B48:05	SQNVRIDPSSL	0.9889	0.6749	12	23
NCOR2-SCARB1	chr12	124907047	chr12	125279814	1384	HLA-B14:01	ERKVTGIPM	0.9841	0.7664	10	19
NCOR2-SCARB1	chr12	124907047	chr12	125279814	1384	HLA-B14:02	ERKVTGIPM	0.9841	0.7664	10	19
NCOR2-SCARB1	chr12	124907047	chr12	125279814	1384	HLA-B50:01	LERKVTGIP	0.1602	0.6707	9	18
NCOR2-SCARB1	chr12	124907047	chr12	125279814	1384	HLA-C06:03	IASFLERKV	0.9643	0.9901	5	14
NCOR2-SCARB1	chr12	124907047	chr12	125279814	1384	HLA-C12:04	IASFLERKV	0.963	0.9872	5	14
NCOR2-SCARB1	chr12	124907047	chr12	125279814	1384	HLA-B39:12	ERKVTGIPM	0.9259	0.606	10	19
NCOR2-SCARB1	chr12	124907047	chr12	125279814	1384	HLA-C12:12	IASFLERKV	0.8806	0.9295	5	14
NCOR2-SCARB1	chr12	124907047	chr12	125279814	1384	HLA-C02:06	IASFLERKV	0.7719	0.9617	5	14
NCOR2-SCARB1	chr12	124907047	chr12	125279814	1384	HLA-B14:03	ERKVTGIPM	0.465	0.7519	10	19
NCOR2-SCARB1	chr12	124907047	chr12	125279814	1384	HLA-C15:02	IASFLERKV	0.9987	0.8289	5	14
NCOR2-SCARB1	chr12	124907047	chr12	125279814	1384	HLA-C16:02	IASFLERKV	0.9507	0.9856	5	14
NCOR2-SCARB1	chr12	124907047	chr12	125279814	1384	HLA-B39:31	ERKVTGIPM	0.9214	0.5977	10	19
NCOR2-SCARB1	chr12	124907047	chr12	125279814	1384	HLA-C16:04	IASFLERKV	0.9206	0.9757	5	14
NCOR2-SCARB1	chr12	124907047	chr12	125279814	1384	HLA-C12:03	IASFLERKV	0.8543	0.9662	5	14
NCOR2-SCARB1	chr12	124907047	chr12	125279814	1384	HLA-C16:01	IASFLERKV	0.7414	0.9716	5	14
NCOR2-SCARB1	chr12	124907047	chr12	125279814	1384	HLA-B50:05	LERKVTGIP	0.1602	0.6707	9	18
NCOR2-SCARB1	chr12	124907047	chr12	125279814	1384	HLA-B50:04	LERKVTGIP	0.1602	0.6707	9	18
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	HLA-B18:01	QEVTGIPM	0.9883	0.8701	11	19
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	HLA-B45:01	SEQEVTGIP	0.9913	0.9238	9	18
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	HLA-B50:02	SEQEVTGIP	0.9856	0.7873	9	18
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	HLA-B41:01	SEQEVTGIP	0.5601	0.9008	9	18
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	HLA-B50:01	SEQEVTGIP	0.4638	0.8064	9	18
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	HLA-B40:06	SEQEVTGIP	0.9877	0.8264	9	18
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	HLA-B44:09	SEQEVTGIPM	0.9877	0.5257	9	19
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	HLA-A02:07	IIDGLSEQEV	0.9578	0.6013	4	14
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	HLA-B18:05	QEVTGIPM	0.9883	0.8701	11	19
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	HLA-B18:11	QEVTGIPM	0.9791	0.9162	11	19
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	HLA-B41:03	SEQEVTGI	0.9654	0.5329	9	17
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	HLA-B39:11	EQEVTGIPM	0.8421	0.9	10	19
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	HLA-B15:09	EQEVTGIPM	0.6212	0.7384	10	19
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	HLA-B50:04	SEQEVTGIP	0.4638	0.8064	9	18
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	HLA-B50:05	SEQEVTGIP	0.4638	0.8064	9	18
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	HLA-A02:03	GLSEQEVTGI	0.9966	0.5902	7	17
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	HLA-B40:04	SEQEVTGIPM	0.9955	0.7952	9	19
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	HLA-B18:11	SEQEVTGIPM	0.9186	0.8429	9	19
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	HLA-B41:03	SEQEVTGIPM	0.7133	0.6432	9	19
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	HLA-A68:02	EIIDGLSEQEV	0.9992	0.8416	3	14
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	HLA-A69:01	EIIDGLSEQEV	0.9976	0.7783	3	14
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	HLA-B27:05	ARTHTNVRI	0.9996	0.8403	8	17
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	HLA-B27:04	ARTHTNVRI	0.9995	0.721	8	17
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	HLA-B27:14	ARTHTNVRI	0.9995	0.7449	8	17
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	HLA-B27:03	ARTHTNVRI	0.9812	0.8546	8	17
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	HLA-B27:06	ARTHTNVRI	0.9993	0.7012	8	17
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	HLA-B27:09	ARTHTNVRI	0.9992	0.8401	8	17
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	HLA-C06:08	ARTHTNVRI	0.8893	0.9819	8	17
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	HLA-C06:02	ARTHTNVRI	0.0085	0.9874	8	17
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	HLA-C06:17	ARTHTNVRI	0.0085	0.9874	8	17

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Potential FusionNeoAntigen Information of NCOR2-SCARB1 in HLA II

NCOR2-SCARB1_124904503_125302253.msa
NCOR2-SCARB1_124907047_125279814.msa
NCOR2-SCARB1_124914159_125279814.msa
NCOR2-SCARB1_124979693_125302253.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0301	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0307	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0310	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0313	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0315	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0315	GKSQNVRIDPSSLSF	10	25
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0318	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0320	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0322	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0326	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0326	GKSQNVRIDPSSLSF	10	25
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0328	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0330	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0332	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0334	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0336	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0342	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0342	GKSQNVRIDPSSLSF	10	25
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0344	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0346	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0348	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0350	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0352	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0354	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0401	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0401	GKSQNVRIDPSSLSF	10	25
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0413	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0413	GKSQNVRIDPSSLSF	10	25
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0422	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0422	GKSQNVRIDPSSLSF	10	25
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0422	RGKSQNVRIDPSSLS	9	24
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0433	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0433	GKSQNVRIDPSSLSF	10	25
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0434	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0435	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0438	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0444	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0444	GKSQNVRIDPSSLSF	10	25
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0462	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0463	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0463	GKSQNVRIDPSSLSF	10	25
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0464	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0466	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0467	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0470	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0472	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0472	GKSQNVRIDPSSLSF	10	25
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0474	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0476	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0476	GKSQNVRIDPSSLSF	10	25
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-0479	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-1107	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-1476	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-1479	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-1525	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB1-1525	GKSQNVRIDPSSLSF	10	25
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB3-0101	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB3-0104	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB3-0105	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB3-0108	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB3-0111	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB3-0112	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB3-0113	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB3-0114	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB3-0201	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB3-0204	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB3-0204	GKSQNVRIDPSSLSF	10	25
NCOR2-SCARB1	chr12	124904503	chr12	125302253	1483	DRB3-0224	KSQNVRIDPSSLSFN	11	26
NCOR2-SCARB1	chr12	124907047	chr12	125279814	1384	DRB1-1503	NFGLIASFLERKVTG	1	16
NCOR2-SCARB1	chr12	124907047	chr12	125279814	1384	DRB1-1503	FGLIASFLERKVTGI	2	17
NCOR2-SCARB1	chr12	124907047	chr12	125279814	1384	DRB1-1523	NFGLIASFLERKVTG	1	16
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	DRB1-1503	VSEIIDGLSEQEVTG	1	16
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	DRB1-1503	SEIIDGLSEQEVTGI	2	17
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	DRB1-1523	VSEIIDGLSEQEVTG	1	16
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1150	DRB1-1523	SEIIDGLSEQEVTGI	2	17
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0301	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0301	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0303	PVQIARTHTNVRIDP	4	19
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0307	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0307	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0310	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0310	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0313	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0313	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0315	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0315	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0318	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0318	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0320	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0320	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0322	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0322	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0326	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0326	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0326	RTHTNVRIDPSSLSF	9	24
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0328	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0328	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0330	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0330	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0332	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0332	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0334	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0334	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0336	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0336	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0342	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0342	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0342	RTHTNVRIDPSSLSF	9	24
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0344	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0344	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0346	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0346	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0348	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0348	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0350	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0350	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0352	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0352	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0354	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0354	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0401	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0401	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0401	RTHTNVRIDPSSLSF	9	24
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0413	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0413	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0413	RTHTNVRIDPSSLSF	9	24
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0422	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0422	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0422	RTHTNVRIDPSSLSF	9	24
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0422	ARTHTNVRIDPSSLS	8	23
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0433	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0433	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0433	RTHTNVRIDPSSLSF	9	24
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0434	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0434	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0435	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0435	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0438	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0438	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0444	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0444	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0462	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0462	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0463	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0463	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0463	RTHTNVRIDPSSLSF	9	24
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0464	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0464	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0466	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0466	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0467	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0470	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0470	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0472	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0472	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0472	RTHTNVRIDPSSLSF	9	24
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0474	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0474	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0476	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0476	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0476	RTHTNVRIDPSSLSF	9	24
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0479	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-0479	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-1107	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-1107	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-1429	PVQIARTHTNVRIDP	4	19
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-1452	PVQIARTHTNVRIDP	4	19
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-1476	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-1476	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-1479	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-1479	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-1525	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB1-1525	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB3-0101	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB3-0101	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB3-0104	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB3-0104	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB3-0105	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB3-0105	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB3-0108	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB3-0108	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB3-0111	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB3-0111	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB3-0112	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB3-0112	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB3-0113	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB3-0113	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB3-0201	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB3-0201	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB3-0204	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB3-0204	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB3-0224	HTNVRIDPSSLSFNM	11	26
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB3-0224	THTNVRIDPSSLSFN	10	25
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB5-0106	PVQIARTHTNVRIDP	4	19
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB5-0106	YPVQIARTHTNVRID	3	18
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB5-0111	PVQIARTHTNVRIDP	4	19
NCOR2-SCARB1	chr12	124979693	chr12	125302253	106	DRB5-0205	PVQIARTHTNVRIDP	4	19

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Fusion breakpoint peptide structures of NCOR2-SCARB1

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
586	ASFLERKVTGIPMN	NCOR2	SCARB1	chr12	124907047	chr12	125279814	1384

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
1120	DGLSEQEVTGIPMN	NCOR2	SCARB1	chr12	124914159	chr12	125279814	1150

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
7314	QIARTHTNVRIDPS	NCOR2	SCARB1	chr12	124979693	chr12	125302253	106

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
10798	YRRRGKSQNVRIDP	NCOR2	SCARB1	chr12	124904503	chr12	125302253	1483

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of NCOR2-SCARB1

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	586	ASFLERKVTGIPMN	-7.15543	-7.26883
HLA-B14:02	3BVN	586	ASFLERKVTGIPMN	-4.77435	-5.80965
HLA-B52:01	3W39	586	ASFLERKVTGIPMN	-6.80875	-6.92215
HLA-B52:01	3W39	586	ASFLERKVTGIPMN	-4.20386	-5.23916
HLA-A11:01	4UQ2	586	ASFLERKVTGIPMN	-7.5194	-8.5547
HLA-A11:01	4UQ2	586	ASFLERKVTGIPMN	-6.9601	-7.0735
HLA-A24:02	5HGA	586	ASFLERKVTGIPMN	-7.52403	-7.63743
HLA-A24:02	5HGA	586	ASFLERKVTGIPMN	-5.82433	-6.85963
HLA-B27:05	6PYJ	586	ASFLERKVTGIPMN	-3.28285	-4.31815
HLA-B44:05	3DX8	586	ASFLERKVTGIPMN	-5.91172	-6.94702
HLA-B44:05	3DX8	586	ASFLERKVTGIPMN	-4.24346	-4.35686
HLA-B14:02	3BVN	1120	DGLSEQEVTGIPMN	-7.15543	-7.26883
HLA-B14:02	3BVN	1120	DGLSEQEVTGIPMN	-4.77435	-5.80965
HLA-B52:01	3W39	1120	DGLSEQEVTGIPMN	-6.80875	-6.92215
HLA-B52:01	3W39	1120	DGLSEQEVTGIPMN	-4.20386	-5.23916
HLA-A11:01	4UQ2	1120	DGLSEQEVTGIPMN	-7.5194	-8.5547
HLA-A11:01	4UQ2	1120	DGLSEQEVTGIPMN	-6.9601	-7.0735
HLA-A24:02	5HGA	1120	DGLSEQEVTGIPMN	-7.52403	-7.63743
HLA-A24:02	5HGA	1120	DGLSEQEVTGIPMN	-5.82433	-6.85963
HLA-B27:05	6PYJ	1120	DGLSEQEVTGIPMN	-3.28285	-4.31815
HLA-B44:05	3DX8	1120	DGLSEQEVTGIPMN	-5.91172	-6.94702
HLA-B44:05	3DX8	1120	DGLSEQEVTGIPMN	-4.24346	-4.35686
HLA-B14:02	3BVN	7314	QIARTHTNVRIDPS	-7.15543	-7.26883
HLA-B14:02	3BVN	7314	QIARTHTNVRIDPS	-4.77435	-5.80965
HLA-B52:01	3W39	7314	QIARTHTNVRIDPS	-6.80875	-6.92215
HLA-B52:01	3W39	7314	QIARTHTNVRIDPS	-4.20386	-5.23916
HLA-A11:01	4UQ2	7314	QIARTHTNVRIDPS	-7.5194	-8.5547
HLA-A11:01	4UQ2	7314	QIARTHTNVRIDPS	-6.9601	-7.0735
HLA-A24:02	5HGA	7314	QIARTHTNVRIDPS	-7.52403	-7.63743
HLA-A24:02	5HGA	7314	QIARTHTNVRIDPS	-5.82433	-6.85963
HLA-B27:05	6PYJ	7314	QIARTHTNVRIDPS	-3.28285	-4.31815
HLA-B44:05	3DX8	7314	QIARTHTNVRIDPS	-5.91172	-6.94702
HLA-B44:05	3DX8	7314	QIARTHTNVRIDPS	-4.24346	-4.35686
HLA-B14:02	3BVN	10798	YRRRGKSQNVRIDP	-7.15543	-7.26883
HLA-B14:02	3BVN	10798	YRRRGKSQNVRIDP	-4.77435	-5.80965
HLA-B52:01	3W39	10798	YRRRGKSQNVRIDP	-6.80875	-6.92215
HLA-B52:01	3W39	10798	YRRRGKSQNVRIDP	-4.20386	-5.23916
HLA-A11:01	4UQ2	10798	YRRRGKSQNVRIDP	-7.5194	-8.5547
HLA-A11:01	4UQ2	10798	YRRRGKSQNVRIDP	-6.9601	-7.0735
HLA-A24:02	5HGA	10798	YRRRGKSQNVRIDP	-7.52403	-7.63743
HLA-A24:02	5HGA	10798	YRRRGKSQNVRIDP	-5.82433	-6.85963
HLA-B27:05	6PYJ	10798	YRRRGKSQNVRIDP	-3.28285	-4.31815
HLA-B44:05	3DX8	10798	YRRRGKSQNVRIDP	-5.91172	-6.94702
HLA-B44:05	3DX8	10798	YRRRGKSQNVRIDP	-4.24346	-4.35686

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Vaccine Design for the FusionNeoAntigens of NCOR2-SCARB1

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
NCOR2-SCARB1	chr12	124904503	chr12	125302253	12	23	SQNVRIDPSSL	CAGAACGTGCGCATCGACCCCAGTAGCCTGTCC
NCOR2-SCARB1	chr12	124904503	chr12	125302253	7	16	RRRGKSQNV	CGCCGCGGCAAGAGCCAGAACGTGCGC
NCOR2-SCARB1	chr12	124904503	chr12	125302253	8	17	RRGKSQNVR	CGCGGCAAGAGCCAGAACGTGCGCATC
NCOR2-SCARB1	chr12	124907047	chr12	125279814	10	19	ERKVTGIPM	GAGAGGAAGGTCACGGGAATCCCCATG
NCOR2-SCARB1	chr12	124907047	chr12	125279814	5	14	IASFLERKV	ATCGCATCATTCCTGGAGAGGAAGGTC
NCOR2-SCARB1	chr12	124907047	chr12	125279814	9	18	LERKVTGIP	CTGGAGAGGAAGGTCACGGGAATCCCC
NCOR2-SCARB1	chr12	124914159	chr12	125279814	10	19	EQEVTGIPM	GAGCAGGAGGTCACGGGAATCCCCATG
NCOR2-SCARB1	chr12	124914159	chr12	125279814	11	19	QEVTGIPM	CAGGAGGTCACGGGAATCCCCATG
NCOR2-SCARB1	chr12	124914159	chr12	125279814	3	14	EIIDGLSEQEV	GAGATCATCGATGGCCTCTCAGAGCAGGAGGTC
NCOR2-SCARB1	chr12	124914159	chr12	125279814	4	14	IIDGLSEQEV	ATCATCGATGGCCTCTCAGAGCAGGAGGTC
NCOR2-SCARB1	chr12	124914159	chr12	125279814	7	17	GLSEQEVTGI	GGCCTCTCAGAGCAGGAGGTCACGGGAATC
NCOR2-SCARB1	chr12	124914159	chr12	125279814	9	17	SEQEVTGI	TCAGAGCAGGAGGTCACGGGAATC
NCOR2-SCARB1	chr12	124914159	chr12	125279814	9	18	SEQEVTGIP	TCAGAGCAGGAGGTCACGGGAATCCCC
NCOR2-SCARB1	chr12	124914159	chr12	125279814	9	19	SEQEVTGIPM	TCAGAGCAGGAGGTCACGGGAATCCCCATG
NCOR2-SCARB1	chr12	124979693	chr12	125302253	8	17	ARTHTNVRI	GCCCGGACGCACACGAACGTGCGCATC

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
NCOR2-SCARB1	chr12	124904503	chr12	125302253	10	25	GKSQNVRIDPSSLSF	AAGAGCCAGAACGTGCGCATCGACCCCAGTAGCCTGTCCTTCAAC
NCOR2-SCARB1	chr12	124904503	chr12	125302253	11	26	KSQNVRIDPSSLSFN	AGCCAGAACGTGCGCATCGACCCCAGTAGCCTGTCCTTCAACATG
NCOR2-SCARB1	chr12	124904503	chr12	125302253	9	24	RGKSQNVRIDPSSLS	GGCAAGAGCCAGAACGTGCGCATCGACCCCAGTAGCCTGTCCTTC
NCOR2-SCARB1	chr12	124907047	chr12	125279814	1	16	NFGLIASFLERKVTG	AACTTTGGCCTGATCGCATCATTCCTGGAGAGGAAGGTCACGGGA
NCOR2-SCARB1	chr12	124907047	chr12	125279814	2	17	FGLIASFLERKVTGI	TTTGGCCTGATCGCATCATTCCTGGAGAGGAAGGTCACGGGAATC
NCOR2-SCARB1	chr12	124914159	chr12	125279814	1	16	VSEIIDGLSEQEVTG	GTGTCAGAGATCATCGATGGCCTCTCAGAGCAGGAGGTCACGGGA
NCOR2-SCARB1	chr12	124914159	chr12	125279814	2	17	SEIIDGLSEQEVTGI	TCAGAGATCATCGATGGCCTCTCAGAGCAGGAGGTCACGGGAATC
NCOR2-SCARB1	chr12	124979693	chr12	125302253	10	25	THTNVRIDPSSLSFN	ACGCACACGAACGTGCGCATCGACCCCAGTAGCCTGTCCTTCAAC
NCOR2-SCARB1	chr12	124979693	chr12	125302253	11	26	HTNVRIDPSSLSFNM	CACACGAACGTGCGCATCGACCCCAGTAGCCTGTCCTTCAACATG
NCOR2-SCARB1	chr12	124979693	chr12	125302253	3	18	YPVQIARTHTNVRID	TACCCAGTGCAGATCGCCCGGACGCACACGAACGTGCGCATCGAC
NCOR2-SCARB1	chr12	124979693	chr12	125302253	4	19	PVQIARTHTNVRIDP	CCAGTGCAGATCGCCCGGACGCACACGAACGTGCGCATCGACCCC
NCOR2-SCARB1	chr12	124979693	chr12	125302253	8	23	ARTHTNVRIDPSSLS	GCCCGGACGCACACGAACGTGCGCATCGACCCCAGTAGCCTGTCC
NCOR2-SCARB1	chr12	124979693	chr12	125302253	9	24	RTHTNVRIDPSSLSF	CGGACGCACACGAACGTGCGCATCGACCCCAGTAGCCTGTCCTTC

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Information of the samples that have these potential fusion neoantigens of NCOR2-SCARB1

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
BRCA	NCOR2-SCARB1	chr12	124904503	ENST00000405201	chr12	125302253	ENST00000261693	TCGA-B6-A0X1-01A
ESCA	NCOR2-SCARB1	chr12	124907047	ENST00000405201	chr12	125279814	ENST00000261693	TCGA-L5-A891
STAD	NCOR2-SCARB1	chr12	124979693	ENST00000405201	chr12	125302253	ENST00000261693	TCGA-VQ-A91Y-01A
UCEC	NCOR2-SCARB1	chr12	124914159	ENST00000405201	chr12	125279814	ENST00000261693	TCGA-EO-A1Y5-01A

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Potential target of CAR-T therapy development for NCOR2-SCARB1

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SCARB1

chr12:124882664

chr12:125263131

ENST00000376788

444_464

616.3333333333334

Transmembrane

Helical

Tgene

SCARB1

chr12:124882665

chr12:125263132

ENST00000376788

444_464

616.3333333333334

Transmembrane

Helical

Tgene

SCARB1

chr12:124904503

chr12:125302253

ENST00000261693

444_464

734.0

Transmembrane

Helical

Tgene

SCARB1

chr12:124904503

chr12:125302253

ENST00000376788

12_32

616.3333333333334

Transmembrane

Helical

Tgene

SCARB1

chr12:124904503

chr12:125302253

ENST00000376788

444_464

616.3333333333334

Transmembrane

Helical

Tgene

SCARB1

chr12:124904503

chr12:125302253

ENST00000415380

444_464

553.0

Transmembrane

Helical

Tgene

SCARB1

chr12:124907047

chr12:125279814

ENST00000261693

444_464

734.0

Transmembrane

Helical

Tgene

SCARB1

chr12:124907047

chr12:125279814

ENST00000376788

444_464

616.3333333333334

Transmembrane

Helical

Tgene

SCARB1

chr12:124907047

chr12:125279814

ENST00000415380

444_464

553.0

Transmembrane

Helical

Tgene

SCARB1

chr12:124914159

chr12:125279814

ENST00000261693

444_464

734.0

Transmembrane

Helical

Tgene

SCARB1

chr12:124914159

chr12:125279814

ENST00000376788

444_464

616.3333333333334

Transmembrane

Helical

Tgene

SCARB1

chr12:124914159

chr12:125279814

ENST00000415380

444_464

553.0

Transmembrane

Helical

Tgene

SCARB1

chr12:124934361

chr12:125302253

ENST00000261693

444_464

734.0

Transmembrane

Helical

Tgene

SCARB1

chr12:124934361

chr12:125302253

ENST00000376788

12_32

616.3333333333334

Transmembrane

Helical

Tgene

SCARB1

chr12:124934361

chr12:125302253

ENST00000376788

444_464

616.3333333333334

Transmembrane

Helical

Tgene

SCARB1

chr12:124934361

chr12:125302253

ENST00000415380

444_464

553.0

Transmembrane

Helical

Tgene

SCARB1

chr12:124968142

chr12:125263132

ENST00000376788

444_464

616.3333333333334

Transmembrane

Helical

Tgene

SCARB1

chr12:124979693

chr12:125302253

ENST00000261693

444_464

734.0

Transmembrane

Helical

Tgene

SCARB1

chr12:124979693

chr12:125302253

ENST00000376788

12_32

616.3333333333334

Transmembrane

Helical

Tgene

SCARB1

chr12:124979693

chr12:125302253

ENST00000376788

444_464

616.3333333333334

Transmembrane

Helical

Tgene

SCARB1

chr12:124979693

chr12:125302253

ENST00000415380

444_464

553.0

Transmembrane

Helical

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

Top

Related Drugs to NCOR2-SCARB1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to NCOR2-SCARB1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)