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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:NF1-CDK5RAP3

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NF1-CDK5RAP3
FusionPDB ID: 58676
FusionGDB2.0 ID: 58676
HgeneTgene
Gene symbol

NF1

CDK5RAP3

Gene ID

4763

80279

Gene nameneurofibromin 1CDK5 regulatory subunit associated protein 3
SynonymsNFNS|VRNF|WSSC53|HSF-27|IC53|LZAP|MST016|OK/SW-cl.114|PP1553
Cytomap

17q11.2

17q21.32

Type of geneprotein-codingprotein-coding
Descriptionneurofibrominneurofibromatosis 1neurofibromatosis-related protein NF-1truncated neurofibromin 1CDK5 regulatory subunit-associated protein 3CDK5 regulatory subunit associated protein IC53-2LXXLL/leucine-zipper-containing ARF-binding proteinLXXLL/leucine-zipper-containing ARFbinding proteinischemic heart CDK5 activator-binding protein C53
Modification date2020032220200320
UniProtAcc

P21359

Main function of 5'-partner protein: FUNCTION: Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}.

Q96JB5

Main function of 5'-partner protein: FUNCTION: Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress (PubMed:23152784, PubMed:30635284). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629). Required for liver development (By similarity). {ECO:0000250|UniProtKB:Q99LM2, ECO:0000269|PubMed:12054757, ECO:0000269|PubMed:12737517, ECO:0000269|PubMed:15790566, ECO:0000269|PubMed:16173922, ECO:0000269|PubMed:17785205, ECO:0000269|PubMed:19223857, ECO:0000269|PubMed:20228063, ECO:0000269|PubMed:21283629, ECO:0000269|PubMed:23152784, ECO:0000269|PubMed:23478299, ECO:0000269|PubMed:30635284}.; FUNCTION: (Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry. {ECO:0000269|PubMed:21971960}.
Ensembl transtripts involved in fusion geneENST idsENST00000356175, ENST00000358273, 
ENST00000417592, ENST00000431387, 
ENST00000444181, ENST00000581113, 
ENST00000578663, ENST00000338399, 
ENST00000536708, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score47 X 26 X 21=256629 X 8 X 8=576
# samples 6910
** MAII scorelog2(69/25662*10)=-5.21689344093196
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/576*10)=-2.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: NF1 [Title/Abstract] AND CDK5RAP3 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: NF1 [Title/Abstract] AND CDK5RAP3 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NF1(29592357)-CDK5RAP3(46058529), # samples:2
NF1(29592357)-CDK5RAP3(46057959), # samples:2
Anticipated loss of major functional domain due to fusion event.NF1-CDK5RAP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NF1-CDK5RAP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NF1-CDK5RAP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NF1-CDK5RAP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NF1-CDK5RAP3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NF1-CDK5RAP3 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNF1

GO:0043547

positive regulation of GTPase activity

2121371

TgeneCDK5RAP3

GO:0008283

cell proliferation

12054757

TgeneCDK5RAP3

GO:0031398

positive regulation of protein ubiquitination

16173922

TgeneCDK5RAP3

GO:0071569

protein ufmylation

23152784

TgeneCDK5RAP3

GO:1900182

positive regulation of protein localization to nucleus

16173922

TgeneCDK5RAP3

GO:1901798

positive regulation of signal transduction by p53 class mediator

16173922

TgeneCDK5RAP3

GO:1903363

negative regulation of cellular protein catabolic process

16173922

TgeneCDK5RAP3

GO:2000060

positive regulation of ubiquitin-dependent protein catabolic process

16173922



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:29592357/chr17:46058529)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across NF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDK5RAP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000356175NF1chr1729592357+ENST00000536708CDK5RAP3chr1746058529+5663515525453921712
ENST00000356175NF1chr1729592357+ENST00000338399CDK5RAP3chr1746058529+5632515525453921712
ENST00000358273NF1chr1729592357+ENST00000536708CDK5RAP3chr1746058529+5726521825454551733
ENST00000358273NF1chr1729592357+ENST00000338399CDK5RAP3chr1746058529+5695521825454551733

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356175ENST00000536708NF1chr1729592357+CDK5RAP3chr1746058529+0.0011789440.9988211
ENST00000356175ENST00000338399NF1chr1729592357+CDK5RAP3chr1746058529+0.0012497580.9987502
ENST00000358273ENST00000536708NF1chr1729592357+CDK5RAP3chr1746058529+0.0010599230.99894005
ENST00000358273ENST00000338399NF1chr1729592357+CDK5RAP3chr1746058529+0.0011276390.99887234

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for NF1-CDK5RAP3

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
NF1chr1729592357CDK5RAP3chr174605852951551633SKAGNPIFYYVARRYVDRVTEFLQQK
NF1chr1729592357CDK5RAP3chr174605852952181654SKAGNPIFYYVARRYVDRVTEFLQQK

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Potential FusionNeoAntigen Information of NF1-CDK5RAP3 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
NF1-CDK5RAP3_29592357_46058529.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:02RRYVDRVTEF10.5441222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:04RRYVDRVTEF10.68671222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:05RRYVDRVTEF10.7621222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:07RRYVDRVTEF0.99990.55591222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B15:03RRYVDRVTEF0.99070.66531222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:04RRYVDRVTEFL10.76461223
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:05ARRYVDRVTEF10.65371122
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:04ARRYVDRVTEF10.6551122
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:05RRYVDRVTEFL10.8291223
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:02RRYVDRVTEFL10.60581223
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:07RRYVDRVTEFL10.66251223
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:07ARRYVDRVTEF0.99990.5321122
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:46FYYVARRY0.92650.718715
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:10FYYVARRY0.92640.8989715
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:67FYYVARRY0.92320.8477715
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:80FYYVARRY0.92320.8477715
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:27FYYVARRY0.91310.9074715
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C12:16FYYVARRY0.90850.9473715
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:05FYYVARRY0.86050.9097715
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:14RRYVDRVTE0.98520.67381221
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C12:16IFYYVARRY0.30070.9472615
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:80IFYYVARRY0.29950.7749615
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:67IFYYVARRY0.29950.7749615
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:10IFYYVARRY0.16890.8383615
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:46IFYYVARRY0.14720.62615
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:27IFYYVARRY0.12180.8602615
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:05IFYYVARRY0.07560.8168615
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:05FYYVARRYV0.05540.8572716
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:67FYYVARRYV0.04710.825716
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:80FYYVARRYV0.04710.825716
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:10FYYVARRYV0.03630.8775716
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C12:16FYYVARRYV0.01330.9208716
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:27FYYVARRYV0.00450.8883716
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:29FYYVARRYV0.00320.8502716
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:13FYYVARRYV0.00310.7337716
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:14RRYVDRVTEF10.7461222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:03RRYVDRVTEF0.99980.77751222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:19RRYVDRVTEF0.99950.64651222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:95RRYVDRVTEF0.99950.50221222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:05RRYVDRVTEF0.99920.84321222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:67RRYVDRVTEF0.99890.911222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:80RRYVDRVTEF0.99890.911222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:10RRYVDRVTEF0.99870.9261222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:27RRYVDRVTEF0.99850.88881222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:46RRYVDRVTEF0.99790.8361222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:29RRYVDRVTEF0.99740.84161222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:13RRYVDRVTEF0.99560.84641222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C12:16RRYVDRVTEF0.99530.94841222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:14RRYVDRVTEFL10.80341223
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:03RRYVDRVTEFL0.99980.84661223
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:19ARRYVDRVTEF0.99980.69011122
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:03ARRYVDRVTEF0.99970.68341122
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:05ARRYVDRVTEF0.99960.85951122
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:67ARRYVDRVTEF0.99950.93141122
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:80ARRYVDRVTEF0.99950.93141122
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:10ARRYVDRVTEF0.99940.93691122
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:46ARRYVDRVTEF0.99930.86541122
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:02FYYVARRY0.92320.8477715
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:17FYYVARRY0.92230.9436715
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C06:06FYYVARRY0.77820.9704715
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C14:03FYYVARRY0.59410.8932715
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C14:02FYYVARRY0.59410.8932715
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C14:02YYVARRYV0.3820.8716816
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C14:03YYVARRYV0.3820.8716816
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:02IFYYVARRY0.29950.7749615
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C06:02FYYVARRYV0.20170.976716
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C06:17FYYVARRYV0.20170.976716
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:17IFYYVARRY0.18980.9497615
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C06:08FYYVARRYV0.05040.9728716
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:02FYYVARRYV0.04710.825716
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C03:67FYYVARRYV0.02020.9563716
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:04FYYVARRYV0.01160.7429716
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C06:06FYYVARRYV0.01030.973716
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:17FYYVARRYV0.0090.93716
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C06:06IFYYVARRY0.00270.9717615
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C14:02FYYVARRYV0.00240.8526716
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C14:03FYYVARRYV0.00240.8526716
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C14:03IFYYVARRY0.00060.9276615
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C14:02IFYYVARRY0.00060.9276615
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:08RRYVDRVTEF10.65191222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:06RRYVDRVTEF10.68111222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:10RRYVDRVTEF10.79421222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:09RRYVDRVTEF0.99980.74281222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:01RRYVDRVTEF0.99960.54161222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C06:08RRYVDRVTEF0.99950.99121222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:22RRYVDRVTEF0.99910.51341222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:02RRYVDRVTEF0.99890.911222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:17RRYVDRVTEF0.99850.95121222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C14:02RRYVDRVTEF0.99680.91691222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C14:03RRYVDRVTEF0.99680.91691222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B15:68RRYVDRVTEF0.99370.6411222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C06:06RRYVDRVTEF0.99240.97981222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B15:54RRYVDRVTEF0.9920.80941222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C06:17RRYVDRVTEF0.99150.99071222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C06:02RRYVDRVTEF0.99150.99071222
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:10RRYVDRVTEFL10.84681223
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:09RRYVDRVTEFL10.8191223
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:10ARRYVDRVTEF10.76281122
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:08RRYVDRVTEFL10.741223
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:06RRYVDRVTEFL10.77141223
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:06ARRYVDRVTEF10.66311122
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:08ARRYVDRVTEF10.52941122
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-B27:09ARRYVDRVTEF0.99990.64931122
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C14:03ARRYVDRVTEF0.99960.94051122
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C14:02ARRYVDRVTEF0.99960.94051122
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:22ARRYVDRVTEF0.99960.54031122
NF1-CDK5RAP3chr1729592357chr17460585295155HLA-C07:02ARRYVDRVTEF0.99950.93141122

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Potential FusionNeoAntigen Information of NF1-CDK5RAP3 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
NF1-CDK5RAP3_29592357_46058529.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0801NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0801PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0801GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0802NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0803NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0803GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0803PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0803AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0805NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0805PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0805GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0807GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0807NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0808NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0808GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0808PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0809NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0811NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0811GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0811PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0812GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0813GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0813NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0814NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0814GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0814PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0814AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0815GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0815NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0815PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0816NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0816PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0816GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0818NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0818GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0818PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0819GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0819NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0819AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0821NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0823NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0823GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0823PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0823AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0824NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0825GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0825NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0825AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0826NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0826PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0826GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0827NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0827GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0827PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0827AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0829NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0829PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0829GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0829AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0830GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0830NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0830PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0832GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0832NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0832PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0833NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0833GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0833PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0833AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0834GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0834NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0834AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0835NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0835GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0835PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0835AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0836NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0836GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0836PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0836AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0837NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0837GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0837PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0837AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0838NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0838GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0838PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0838AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0839NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0839PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0839GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0840NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0840PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-0840GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1101NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1101GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1101PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1102GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1105NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1105GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1105PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1108NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1108GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1108PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1109NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1109GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1109PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1110NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1110GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1110PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1111NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1111GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1111PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1112NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1112GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1112PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1114GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1114NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1114AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1115NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1115GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1115PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1116GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1119NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1119GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1119PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1120GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1120NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1120AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1121GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1124NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1124GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1124PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1127NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1127GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1127PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1128NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1128GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1128PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1129NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1129GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1129PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1131NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1131GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1131PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1132NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1132GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1132PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1133NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1133GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1133PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1137NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1137GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1139NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1139GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1139PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1145NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1145GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1145PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1145AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1149NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1149GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1149PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1151NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1151GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1151PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1153NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1153GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1153PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1161NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1161GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1161PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1162NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1162GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1162PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1164NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1164GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1164PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1165GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1166NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1166GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1166PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1168GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1168NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1169NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1169GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1169PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1170GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1170AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1172NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1172GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1172PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1172AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1173NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1173GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1173PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1174NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1174GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1174PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1175NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1175GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1175PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1179NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1180NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1180GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1180PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1181NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1181GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1181PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1182GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1182NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1182PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1182AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1186GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1186NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1187NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1187GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1187PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1190NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1190GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1190PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1191NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1191GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1191PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1193NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1193GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1194NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1194GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1194PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1195NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1195GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1195PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1196NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1196GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1196PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1201GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1201AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1203GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1203AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1204GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1204AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1204NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1205GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1205AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1206GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1206AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1207GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1207AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1208GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1208AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1208NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1209GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1209AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1209NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1210GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1210AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1211GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1212GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1213GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1213AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1214GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1214AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1215GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1215AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1216GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1216NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1217GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1217AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1218GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1218AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1219GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1219AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1220GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1221GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1222GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1222AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1222NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1223GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1223AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1301GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1302GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1302NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1302AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1303NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1303PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1303GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1304GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1305NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1305GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1305PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1307NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1307GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1309GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-13100GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-13100NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-13100AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-13100PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-13101NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-13101PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-13101GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1310NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1310PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1310GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1312NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1312PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1312GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1313NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1313PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1313GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1313IFYYVARRYVDRVTE621
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1313AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1314NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1314GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1314PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1315GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1316GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1316NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1317GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1317AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1319GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1321NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1321PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1321GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1322GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1323GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1323NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1323AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1326NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1326GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1326PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1329GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1329NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1330NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1330GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1330PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1330AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1330IFYYVARRYVDRVTE621
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1331GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1331NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1331AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1333NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1333PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1333GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1334GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1334NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1334AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1335GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1336GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1336NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1336PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1337NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1337GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1337PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1338NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1338GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1338PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1338AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1339GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1339NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1339AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1341GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1341NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1343GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1346GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1346NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1346AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1346PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1347NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1347GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1347PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1349NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1349PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1349GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1350NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1350GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1350PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1351GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1352GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1353GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1354GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1355PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1355NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1355GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1356NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1356GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1356PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1357GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1359GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1360NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1360GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1360PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1361GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1362NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1362GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1362PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1363NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1363GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1363PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1364GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1365NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1365GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1365PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1365AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1366NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1366PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1366GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1366AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1367GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1367NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1368GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1369GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1373GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1373NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1373AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1374GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1374NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1374AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1377GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1379GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1380GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1382NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1382GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1382PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1383GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1385NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1385GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1385PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1386GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1386NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1387GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1388PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1388NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1388GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1390NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1390PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1390GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1391GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1392GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1393GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1395NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1395PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1395GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1396GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1396NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1397GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1397NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1397AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1398GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1399GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1399NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1399AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1402GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1402NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1403NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1403GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1403PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1407GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1407NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1407AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1407PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1409NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1413GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1413NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1413PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1414NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1414GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1414PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1414AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1416GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1422NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1422GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1422PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1424GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1424NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1424AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1425NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1425GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1425PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1427NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1427GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1427PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1430NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1430GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1430PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1436NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1436GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1436PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1436AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1440NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1440GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1440PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1441GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1441NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1442NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1442GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1442PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1442AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1444NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1444GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1444PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1444AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1448GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1449GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1449NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1451NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1451GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1451PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1452GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1453NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1453GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1453PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1453AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1463NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1463GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1463PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1463AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1463IFYYVARRYVDRVTE621
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1467NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1467GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1467PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1467AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1468GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1468NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1468AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1468PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1469NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1469GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1469PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1477NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1477GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1477PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1478GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1485NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1485GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1485PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1489GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1489NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1493GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1493NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1493AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1494GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1494NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1498GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1498NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1498PIFYYVARRYVDRVT520
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1501GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1501AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1502GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1503GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1503AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1504GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1504AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1505GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1505AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1506GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1506AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1507GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1507AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1508GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1509GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1509AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1510GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1510AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1510NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1510KAGNPIFYYVARRYV116
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1512GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1512AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1512NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1512KAGNPIFYYVARRYV116
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1513GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1513AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1514GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1516GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1516AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1518GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1518AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1518NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1518KAGNPIFYYVARRYV116
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1519GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1520GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1520AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1521GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1521AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1521NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1521KAGNPIFYYVARRYV116
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1522GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1522AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1523GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1523AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1524GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1524AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1525GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1526GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1528GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1528AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1528NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1529GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1529AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1530GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1530AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1531GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1532GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1532AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1533GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1533AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1535GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1535AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1535NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1535KAGNPIFYYVARRYV116
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1536GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1536AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1537GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1537AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1537NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1537KAGNPIFYYVARRYV116
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1538GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1539GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1540GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1540AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1541GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1541AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1542GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1542AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1543GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1543AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1544GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1545GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1545AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1546GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1546AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1547GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1548GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1548AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1549GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB1-1549AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0103GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0103AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0103NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0106GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0106AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0106NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0106KAGNPIFYYVARRYV116
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0111GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0111AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0202GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0202AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0202NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0202KAGNPIFYYVARRYV116
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0203GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0203AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0203NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0203KAGNPIFYYVARRYV116
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0204GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0204AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0204NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0204KAGNPIFYYVARRYV116
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0205GNPIFYYVARRYVDR318
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0205AGNPIFYYVARRYVD217
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0205NPIFYYVARRYVDRV419
NF1-CDK5RAP3chr1729592357chr17460585295155DRB5-0205KAGNPIFYYVARRYV116

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Fusion breakpoint peptide structures of NF1-CDK5RAP3

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
3682IFYYVARRYVDRVTNF1CDK5RAP3chr1729592357chr17460585295155

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of NF1-CDK5RAP3

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN3682IFYYVARRYVDRVT-7.9962-8.1096
HLA-B14:023BVN3682IFYYVARRYVDRVT-5.70842-6.74372
HLA-B52:013W393682IFYYVARRYVDRVT-6.83737-6.95077
HLA-B52:013W393682IFYYVARRYVDRVT-4.4836-5.5189
HLA-A11:014UQ23682IFYYVARRYVDRVT-10.0067-10.1201
HLA-A11:014UQ23682IFYYVARRYVDRVT-9.03915-10.0745
HLA-A24:025HGA3682IFYYVARRYVDRVT-6.56204-6.67544
HLA-A24:025HGA3682IFYYVARRYVDRVT-5.42271-6.45801
HLA-B44:053DX83682IFYYVARRYVDRVT-7.85648-8.89178
HLA-B44:053DX83682IFYYVARRYVDRVT-5.3978-5.5112
HLA-A02:016TDR3682IFYYVARRYVDRVT-3.37154-4.40684

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Vaccine Design for the FusionNeoAntigens of NF1-CDK5RAP3

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
NF1-CDK5RAP3chr1729592357chr17460585291122ARRYVDRVTEFACGGAGGTATGTGGACCGAGTGACTGAATTCCT
NF1-CDK5RAP3chr1729592357chr17460585291221RRYVDRVTEGAGGTATGTGGACCGAGTGACTGAATT
NF1-CDK5RAP3chr1729592357chr17460585291222RRYVDRVTEFGAGGTATGTGGACCGAGTGACTGAATTCCT
NF1-CDK5RAP3chr1729592357chr17460585291223RRYVDRVTEFLGAGGTATGTGGACCGAGTGACTGAATTCCTCCA
NF1-CDK5RAP3chr1729592357chr1746058529615IFYYVARRYTTTTTATTATGTTGCACGGAGGTATGT
NF1-CDK5RAP3chr1729592357chr1746058529715FYYVARRYTTATTATGTTGCACGGAGGTATGT
NF1-CDK5RAP3chr1729592357chr1746058529716FYYVARRYVTTATTATGTTGCACGGAGGTATGTGGA
NF1-CDK5RAP3chr1729592357chr1746058529816YYVARRYVTTATGTTGCACGGAGGTATGTGGA

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
NF1-CDK5RAP3chr1729592357chr1746058529116KAGNPIFYYVARRYVAGCTGGGAATCCTATTTTTTATTATGTTGCACGGAGGTATGTGGA
NF1-CDK5RAP3chr1729592357chr1746058529217AGNPIFYYVARRYVDTGGGAATCCTATTTTTTATTATGTTGCACGGAGGTATGTGGACCG
NF1-CDK5RAP3chr1729592357chr1746058529318GNPIFYYVARRYVDRGAATCCTATTTTTTATTATGTTGCACGGAGGTATGTGGACCGAGT
NF1-CDK5RAP3chr1729592357chr1746058529419NPIFYYVARRYVDRVTCCTATTTTTTATTATGTTGCACGGAGGTATGTGGACCGAGTGAC
NF1-CDK5RAP3chr1729592357chr1746058529520PIFYYVARRYVDRVTTATTTTTTATTATGTTGCACGGAGGTATGTGGACCGAGTGACTGA
NF1-CDK5RAP3chr1729592357chr1746058529621IFYYVARRYVDRVTETTTTTATTATGTTGCACGGAGGTATGTGGACCGAGTGACTGAATT

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Information of the samples that have these potential fusion neoantigens of NF1-CDK5RAP3

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
BRCANF1-CDK5RAP3chr1729592357ENST00000356175chr1746058529ENST00000338399TCGA-BH-A18R-01A

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Potential target of CAR-T therapy development for NF1-CDK5RAP3

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to NF1-CDK5RAP3

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NF1-CDK5RAP3

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNF1C0027831Neurofibromatosis 144CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneNF1C1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome10CLINGEN
HgeneNF1C0349639Juvenile Myelomonocytic Leukemia7CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneNF1C2931482Neurofibromatosis-Noonan syndrome6CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneNF1C0553586Cafe-au-lait macules with pulmonary stenosis5CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneNF1C0162678Neurofibromatoses3CGI;CTD_human;GENOMICS_ENGLAND
HgeneNF1C0004114Astrocytoma2CTD_human
HgeneNF1C0023467Leukemia, Myelocytic, Acute2CTD_human
HgeneNF1C0025202melanoma2CGI;CTD_human
HgeneNF1C0026998Acute Myeloid Leukemia, M12CTD_human
HgeneNF1C0205768Subependymal Giant Cell Astrocytoma2CTD_human
HgeneNF1C0206727Nerve Sheath Tumors2CTD_human
HgeneNF1C0280783Juvenile Pilocytic Astrocytoma2CTD_human
HgeneNF1C0280785Diffuse Astrocytoma2CTD_human
HgeneNF1C0334579Anaplastic astrocytoma2CTD_human
HgeneNF1C0334580Protoplasmic astrocytoma2CTD_human
HgeneNF1C0334581Gemistocytic astrocytoma2CTD_human
HgeneNF1C0334582Fibrillary Astrocytoma2CTD_human
HgeneNF1C0334583Pilocytic Astrocytoma2CTD_human
HgeneNF1C0338070Childhood Cerebral Astrocytoma2CTD_human
HgeneNF1C0547065Mixed oligoastrocytoma2CTD_human
HgeneNF1C0750935Cerebral Astrocytoma2CTD_human
HgeneNF1C0750936Intracranial Astrocytoma2CTD_human
HgeneNF1C0751689Peripheral Nerve Sheath Neoplasm2CTD_human
HgeneNF1C0751691Perineurioma2CTD_human
HgeneNF1C1704230Grade I Astrocytoma2CTD_human
HgeneNF1C1834235NEUROFIBROMATOSIS, FAMILIAL SPINAL2CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneNF1C1879321Acute Myeloid Leukemia (AML-M2)2CTD_human
HgeneNF1C0001430Adenoma1CTD_human
HgeneNF1C0004352Autistic Disorder1CTD_human
HgeneNF1C0016057Fibrosarcoma1CTD_human
HgeneNF1C0017636Glioblastoma1CTD_human
HgeneNF1C0017638Glioma1CGI;CTD_human
HgeneNF1C0020796Profound Mental Retardation1CTD_human
HgeneNF1C0023186Learning Disorders1CTD_human
HgeneNF1C0023827liposarcoma1CTD_human
HgeneNF1C0025363Mental Retardation, Psychosocial1CTD_human
HgeneNF1C0026654Moyamoya Disease1GENOMICS_ENGLAND
HgeneNF1C0027809Neurilemmoma1CTD_human
HgeneNF1C0027830neurofibroma1CTD_human
HgeneNF1C0027962Melanocytic nevus1CTD_human
HgeneNF1C0028326Noonan Syndrome1GENOMICS_ENGLAND
HgeneNF1C0031511Pheochromocytoma1CTD_human
HgeneNF1C0035320Retinal Neovascularization1CTD_human
HgeneNF1C0205646Adenoma, Basal Cell1CTD_human
HgeneNF1C0205647Follicular adenoma1CTD_human
HgeneNF1C0205648Adenoma, Microcystic1CTD_human
HgeneNF1C0205649Adenoma, Monomorphic1CTD_human
HgeneNF1C0205650Papillary adenoma1CTD_human
HgeneNF1C0205651Adenoma, Trabecular1CTD_human
HgeneNF1C0205824Liposarcoma, Dedifferentiated1CTD_human
HgeneNF1C0205825Liposarcoma, Pleomorphic1CTD_human
HgeneNF1C0205944Sarcoma, Epithelioid1CTD_human
HgeneNF1C0205945Sarcoma, Spindle Cell1CTD_human
HgeneNF1C0259783mixed gliomas1CTD_human
HgeneNF1C0334588Giant Cell Glioblastoma1CTD_human
HgeneNF1C0555198Malignant Glioma1CTD_human
HgeneNF1C0751262Adult Learning Disorders1CTD_human
HgeneNF1C0751263Learning Disturbance1CTD_human
HgeneNF1C0751265Learning Disabilities1CTD_human
HgeneNF1C0751374Schwannomatosis, Plexiform1CTD_human
HgeneNF1C0917816Mental deficiency1CTD_human
HgeneNF1C0917817Neurofibromatosis 31CTD_human
HgeneNF1C1257877Pheochromocytoma, Extra-Adrenal1CTD_human
HgeneNF1C1261473Sarcoma1CTD_human
HgeneNF1C1330966Developmental Academic Disorder1CTD_human
HgeneNF1C1370889Liposarcoma, well differentiated1CTD_human
HgeneNF1C1621958Glioblastoma Multiforme1CTD_human
HgeneNF1C3150928NF1 Microdeletion Syndrome1ORPHANET
HgeneNF1C3714756Intellectual Disability1CTD_human