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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:NSD1-ZNF346

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NSD1-ZNF346
FusionPDB ID: 60438
FusionGDB2.0 ID: 60438
HgeneTgene
Gene symbol

NSD1

ZNF346

Gene ID

64324

23567

Gene namenuclear receptor binding SET domain protein 1zinc finger protein 346
SynonymsARA267|KMT3B|SOTOS|SOTOS1|STOJAZ|Zfp346
Cytomap

5q35.3

5q35.2

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificH3-K36-HMTaseH4-K20-HMTaseNR-binding SET domain-containing proteinandrogen receptor coactivator 267 kDa proteinandrogen receptor-associated coregulator 267androgen receptor-aszinc finger protein 346double-stranded RNA-binding zinc finger protein JAZjust another zinc finger protein
Modification date2020032120200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000347982, ENST00000354179, 
ENST00000361032, ENST00000439151, 
ENST00000511258, 		ENST00000503039, 
ENST00000512315, ENST00000261948, 
ENST00000358149, ENST00000503425, 
ENST00000506693, ENST00000511834, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 14 X 17=54744 X 12 X 8=384
# samples 3718
** MAII scorelog2(37/5474*10)=-3.88699825884864
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/384*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: NSD1 [Title/Abstract] AND ZNF346 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: NSD1 [Title/Abstract] AND ZNF346 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NSD1(176563031)-ZNF346(176489059), # samples:2
NSD1(176563031)-ZNF346(176468127), # samples:2
NSD1(176619020)-ZNF346(176489059), # samples:2
NSD1(176696808)-ZNF346(176468127), # samples:2
NSD1(176678854)-ZNF346(176468127), # samples:2
ZNF346(176471534)-NSD1(176631121), # samples:1
Anticipated loss of major functional domain due to fusion event.NSD1-ZNF346 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NSD1-ZNF346 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NSD1-ZNF346 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NSD1-ZNF346 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF346-NSD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF346-NSD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NSD1-ZNF346 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NSD1-ZNF346 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NSD1-ZNF346 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NSD1-ZNF346 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NSD1-ZNF346 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNSD1

GO:0045893

positive regulation of transcription, DNA-templated

11509567



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:176563031/chr5:176489059)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across NSD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF346 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000354179NSD1chr5176619020+ENST00000506693ZNF346chr5176489058+1240416160597145
ENST00000354179NSD1chr5176619020+ENST00000358149ZNF346chr5176489058+1984416160597145
ENST00000354179NSD1chr5176619020+ENST00000512315ZNF346chr5176489058+1773416160597145
ENST00000354179NSD1chr5176619020+ENST00000503425ZNF346chr5176489058+965416160597145
ENST00000354179NSD1chr5176619020+ENST00000261948ZNF346chr5176489058+1973416160597145
ENST00000354179NSD1chr5176619020+ENST00000511834ZNF346chr5176489058+1964416160597145
ENST00000354179NSD1chr5176619020+ENST00000503039ZNF346chr5176489058+2408416160597145
ENST00000439151NSD1chr5176619020+ENST00000506693ZNF346chr5176489058+19321108451289414
ENST00000439151NSD1chr5176619020+ENST00000358149ZNF346chr5176489058+26761108451289414
ENST00000439151NSD1chr5176619020+ENST00000512315ZNF346chr5176489058+24651108451289414
ENST00000439151NSD1chr5176619020+ENST00000503425ZNF346chr5176489058+16571108451289414
ENST00000439151NSD1chr5176619020+ENST00000261948ZNF346chr5176489058+26651108451289414
ENST00000439151NSD1chr5176619020+ENST00000511834ZNF346chr5176489058+26561108451289414
ENST00000439151NSD1chr5176619020+ENST00000503039ZNF346chr5176489058+31001108451289414
ENST00000347982NSD1chr5176619020+ENST00000506693ZNF346chr5176489058+1181357101538145
ENST00000347982NSD1chr5176619020+ENST00000358149ZNF346chr5176489058+1925357101538145
ENST00000347982NSD1chr5176619020+ENST00000512315ZNF346chr5176489058+1714357101538145
ENST00000347982NSD1chr5176619020+ENST00000503425ZNF346chr5176489058+906357101538145
ENST00000347982NSD1chr5176619020+ENST00000261948ZNF346chr5176489058+1914357101538145
ENST00000347982NSD1chr5176619020+ENST00000511834ZNF346chr5176489058+1905357101538145
ENST00000347982NSD1chr5176619020+ENST00000503039ZNF346chr5176489058+2349357101538145
ENST00000354179NSD1chr5176619020+ENST00000506693ZNF346chr5176489059+1240416160597145
ENST00000354179NSD1chr5176619020+ENST00000358149ZNF346chr5176489059+1984416160597145
ENST00000354179NSD1chr5176619020+ENST00000512315ZNF346chr5176489059+1773416160597145
ENST00000354179NSD1chr5176619020+ENST00000503425ZNF346chr5176489059+965416160597145
ENST00000354179NSD1chr5176619020+ENST00000261948ZNF346chr5176489059+1973416160597145
ENST00000354179NSD1chr5176619020+ENST00000511834ZNF346chr5176489059+1964416160597145
ENST00000354179NSD1chr5176619020+ENST00000503039ZNF346chr5176489059+2408416160597145
ENST00000439151NSD1chr5176619020+ENST00000506693ZNF346chr5176489059+19321108451289414
ENST00000439151NSD1chr5176619020+ENST00000358149ZNF346chr5176489059+26761108451289414
ENST00000439151NSD1chr5176619020+ENST00000512315ZNF346chr5176489059+24651108451289414
ENST00000439151NSD1chr5176619020+ENST00000503425ZNF346chr5176489059+16571108451289414
ENST00000439151NSD1chr5176619020+ENST00000261948ZNF346chr5176489059+26651108451289414
ENST00000439151NSD1chr5176619020+ENST00000511834ZNF346chr5176489059+26561108451289414
ENST00000439151NSD1chr5176619020+ENST00000503039ZNF346chr5176489059+31001108451289414
ENST00000347982NSD1chr5176619020+ENST00000506693ZNF346chr5176489059+1181357101538145
ENST00000347982NSD1chr5176619020+ENST00000358149ZNF346chr5176489059+1925357101538145
ENST00000347982NSD1chr5176619020+ENST00000512315ZNF346chr5176489059+1714357101538145
ENST00000347982NSD1chr5176619020+ENST00000503425ZNF346chr5176489059+906357101538145
ENST00000347982NSD1chr5176619020+ENST00000261948ZNF346chr5176489059+1914357101538145
ENST00000347982NSD1chr5176619020+ENST00000511834ZNF346chr5176489059+1905357101538145
ENST00000347982NSD1chr5176619020+ENST00000503039ZNF346chr5176489059+2349357101538145

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000354179ENST00000506693NSD1chr5176619020+ZNF346chr5176489058+0.035997980.9640021
ENST00000354179ENST00000358149NSD1chr5176619020+ZNF346chr5176489058+0.183609140.8163909
ENST00000354179ENST00000512315NSD1chr5176619020+ZNF346chr5176489058+0.174520120.82547987
ENST00000354179ENST00000503425NSD1chr5176619020+ZNF346chr5176489058+0.0443146820.9556853
ENST00000354179ENST00000261948NSD1chr5176619020+ZNF346chr5176489058+0.192308650.80769134
ENST00000354179ENST00000511834NSD1chr5176619020+ZNF346chr5176489058+0.18880410.81119585
ENST00000354179ENST00000503039NSD1chr5176619020+ZNF346chr5176489058+0.229357320.77064276
ENST00000439151ENST00000506693NSD1chr5176619020+ZNF346chr5176489058+0.0015967150.99840325
ENST00000439151ENST00000358149NSD1chr5176619020+ZNF346chr5176489058+0.0013403410.9986596
ENST00000439151ENST00000512315NSD1chr5176619020+ZNF346chr5176489058+0.0014586130.99854136
ENST00000439151ENST00000503425NSD1chr5176619020+ZNF346chr5176489058+0.001242510.9987575
ENST00000439151ENST00000261948NSD1chr5176619020+ZNF346chr5176489058+0.0013805370.99861944
ENST00000439151ENST00000511834NSD1chr5176619020+ZNF346chr5176489058+0.0013866050.99861336
ENST00000439151ENST00000503039NSD1chr5176619020+ZNF346chr5176489058+0.0012461060.9987539
ENST00000347982ENST00000506693NSD1chr5176619020+ZNF346chr5176489058+0.0345441140.9654559
ENST00000347982ENST00000358149NSD1chr5176619020+ZNF346chr5176489058+0.106897470.89310247
ENST00000347982ENST00000512315NSD1chr5176619020+ZNF346chr5176489058+0.0839947760.9160052
ENST00000347982ENST00000503425NSD1chr5176619020+ZNF346chr5176489058+0.038861870.9611381
ENST00000347982ENST00000261948NSD1chr5176619020+ZNF346chr5176489058+0.1041367950.89586323
ENST00000347982ENST00000511834NSD1chr5176619020+ZNF346chr5176489058+0.102810270.8971897
ENST00000347982ENST00000503039NSD1chr5176619020+ZNF346chr5176489058+0.163872030.836128
ENST00000354179ENST00000506693NSD1chr5176619020+ZNF346chr5176489059+0.035997980.9640021
ENST00000354179ENST00000358149NSD1chr5176619020+ZNF346chr5176489059+0.183609140.8163909
ENST00000354179ENST00000512315NSD1chr5176619020+ZNF346chr5176489059+0.174520120.82547987
ENST00000354179ENST00000503425NSD1chr5176619020+ZNF346chr5176489059+0.0443146820.9556853
ENST00000354179ENST00000261948NSD1chr5176619020+ZNF346chr5176489059+0.192308650.80769134
ENST00000354179ENST00000511834NSD1chr5176619020+ZNF346chr5176489059+0.18880410.81119585
ENST00000354179ENST00000503039NSD1chr5176619020+ZNF346chr5176489059+0.229357320.77064276
ENST00000439151ENST00000506693NSD1chr5176619020+ZNF346chr5176489059+0.0015967150.99840325
ENST00000439151ENST00000358149NSD1chr5176619020+ZNF346chr5176489059+0.0013403410.9986596
ENST00000439151ENST00000512315NSD1chr5176619020+ZNF346chr5176489059+0.0014586130.99854136
ENST00000439151ENST00000503425NSD1chr5176619020+ZNF346chr5176489059+0.001242510.9987575
ENST00000439151ENST00000261948NSD1chr5176619020+ZNF346chr5176489059+0.0013805370.99861944
ENST00000439151ENST00000511834NSD1chr5176619020+ZNF346chr5176489059+0.0013866050.99861336
ENST00000439151ENST00000503039NSD1chr5176619020+ZNF346chr5176489059+0.0012461060.9987539
ENST00000347982ENST00000506693NSD1chr5176619020+ZNF346chr5176489059+0.0345441140.9654559
ENST00000347982ENST00000358149NSD1chr5176619020+ZNF346chr5176489059+0.106897470.89310247
ENST00000347982ENST00000512315NSD1chr5176619020+ZNF346chr5176489059+0.0839947760.9160052
ENST00000347982ENST00000503425NSD1chr5176619020+ZNF346chr5176489059+0.038861870.9611381
ENST00000347982ENST00000261948NSD1chr5176619020+ZNF346chr5176489059+0.1041367950.89586323
ENST00000347982ENST00000511834NSD1chr5176619020+ZNF346chr5176489059+0.102810270.8971897
ENST00000347982ENST00000503039NSD1chr5176619020+ZNF346chr5176489059+0.163872030.836128

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for NSD1-ZNF346

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
NSD1chr5176619020ZNF346chr51764890581108354CSDPLINTHSKMKAGKGYPCKTCKIV
NSD1chr5176619020ZNF346chr517648905835785CSDPLINTHSKMKAGKGYPCKTCKIV
NSD1chr5176619020ZNF346chr517648905841685CSDPLINTHSKMKAGKGYPCKTCKIV
NSD1chr5176619020ZNF346chr51764890591108354CSDPLINTHSKMKAGKGYPCKTCKIV
NSD1chr5176619020ZNF346chr517648905935785CSDPLINTHSKMKAGKGYPCKTCKIV
NSD1chr5176619020ZNF346chr517648905941685CSDPLINTHSKMKAGKGYPCKTCKIV

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Potential FusionNeoAntigen Information of NSD1-ZNF346 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
NSD1-ZNF346_176619020_176489058.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
NSD1-ZNF346chr5176619020chr5176489058357HLA-B15:03SKMKAGKGY0.04180.6174918
NSD1-ZNF346chr5176619020chr5176489058357HLA-B15:18SKMKAGKGY0.02650.5695918
NSD1-ZNF346chr5176619020chr5176489058357HLA-B15:18THSKMKAGKGY0.90650.5835718
NSD1-ZNF346chr5176619020chr5176489058357HLA-A30:01KAGKGYPCK0.98970.91391221
NSD1-ZNF346chr5176619020chr5176489058357HLA-B48:02SKMKAGKGY0.11010.7592918
NSD1-ZNF346chr5176619020chr5176489058357HLA-B15:53SKMKAGKGY0.04110.7751918
NSD1-ZNF346chr5176619020chr5176489058357HLA-B15:54SKMKAGKGY0.01630.7399918

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Potential FusionNeoAntigen Information of NSD1-ZNF346 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
NSD1-ZNF346_176619020_176489058.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1102DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1102SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1102PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1102CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1103DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1103SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1103PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1103CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1111DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1111SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1114DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1114SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1116DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1116SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1116PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1116CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1120DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1120SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1121DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1121SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1121PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1136DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1136SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1136PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1136CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1141DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1141SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1141PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1141CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1148DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1148SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1148PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1148CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1155DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1155SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1155PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1155CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1159DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1159SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1159PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1159CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1163DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1163SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1163PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1163CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1165DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1165SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1165PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1165CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1168DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1168SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1169DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1170DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1170SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1170PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1176DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1176SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1176PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1176CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1182DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1185DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1185SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1185PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1185CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1186DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1186SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1301DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1301SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1301PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1301CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1302DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1302SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1304DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1304SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1308DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1308SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1308PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1308CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1309DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1309SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1315DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1315SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1315PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1316DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1316SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1317DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1317SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1319DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1319SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1319PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1319CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1320DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1320SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1320PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1320CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1322DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1322SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1322PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1322CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1323DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1323SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1324DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1324SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1324PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1324CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1327DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1327SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1327PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1329DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1329SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1332DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1332SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1334DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1334SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1335DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1335SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1335PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1335CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1336DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1336SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1339DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1339SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1341DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1343DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1343SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1348DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1348SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1351DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1351SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1351PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1351CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1352DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1352SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1352PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1352CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1353DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1353SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1353PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1353CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1354DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1354SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1357DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1357SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1357PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1359DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1359SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1359PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1359CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1361DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1361SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1361PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1361CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1363DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1363SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1364DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1364SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1364PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1364CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1368DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1368SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1368PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1368CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1369DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1369SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1369PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1369CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1370DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1370SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1370PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1370CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1371DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1371SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1372DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1372SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1372PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1372CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1373DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1373SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1374DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1374SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1375DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1375SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1376DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1376SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1376CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1376PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1378DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1378SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1378PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1378CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1379DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1379SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1379PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1379CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1380DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1380SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1380PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1380CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1383DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1383SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1383PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1383CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1384DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1384SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1384PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1384CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1387DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1387SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1387PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1387CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1391DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1391SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1391PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1391CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1392DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1392SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1392PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1392CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1393DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1393SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1396DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1396SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1397DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1397SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1398DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1398SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1398PLINTHSKMKAGKGY318
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1398CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1399DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1399SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1412DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1416DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1416SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1416CSDPLINTHSKMKAG015
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1437DPLINTHSKMKAGKG217
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1437SDPLINTHSKMKAGK116
NSD1-ZNF346chr5176619020chr5176489058357DRB1-1484DPLINTHSKMKAGKG217

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Fusion breakpoint peptide structures of NSD1-ZNF346

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
6414NTHSKMKAGKGYPCNSD1ZNF346chr5176619020chr5176489058357

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of NSD1-ZNF346

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN6414NTHSKMKAGKGYPC-6.35143-7.38673
HLA-B14:023BVN6414NTHSKMKAGKGYPC-5.20162-5.31502
HLA-B52:013W396414NTHSKMKAGKGYPC-6.03049-6.14389
HLA-B52:013W396414NTHSKMKAGKGYPC-5.12323-6.15853
HLA-A24:025HGA6414NTHSKMKAGKGYPC-9.81198-9.92538
HLA-A24:025HGA6414NTHSKMKAGKGYPC-7.16433-8.19963
HLA-B44:053DX86414NTHSKMKAGKGYPC-6.46131-6.57471
HLA-B44:053DX86414NTHSKMKAGKGYPC-3.08576-4.12106
HLA-A02:016TDR6414NTHSKMKAGKGYPC-5.03933-5.15273

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Vaccine Design for the FusionNeoAntigens of NSD1-ZNF346

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
NSD1-ZNF346chr5176619020chr51764890581221KAGKGYPCKAAGCTGGAAAGGGCTACCCCTGCAAAA
NSD1-ZNF346chr5176619020chr5176489058718THSKMKAGKGYCACATTCAAAAATGAAAGCTGGAAAGGGCTACC
NSD1-ZNF346chr5176619020chr5176489058918SKMKAGKGYCAAAAATGAAAGCTGGAAAGGGCTACC

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
NSD1-ZNF346chr5176619020chr5176489058015CSDPLINTHSKMKAGGTTCTGATCCGTTGATTAACACACATTCAAAAATGAAAGCTGGAA
NSD1-ZNF346chr5176619020chr5176489058116SDPLINTHSKMKAGKCTGATCCGTTGATTAACACACATTCAAAAATGAAAGCTGGAAAGG
NSD1-ZNF346chr5176619020chr5176489058217DPLINTHSKMKAGKGATCCGTTGATTAACACACATTCAAAAATGAAAGCTGGAAAGGGCT
NSD1-ZNF346chr5176619020chr5176489058318PLINTHSKMKAGKGYCGTTGATTAACACACATTCAAAAATGAAAGCTGGAAAGGGCTACC

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Information of the samples that have these potential fusion neoantigens of NSD1-ZNF346

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
BRCANSD1-ZNF346chr5176619020ENST00000347982chr5176489058ENST00000261948TCGA-D8-A140

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Potential target of CAR-T therapy development for NSD1-ZNF346

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to NSD1-ZNF346

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NSD1-ZNF346

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource