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Fusion Protein:OAZ1-YBX2

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: OAZ1-YBX2
	FusionPDB ID: 61292
	FusionGDB2.0 ID: 61292
		Hgene	Tgene
	Gene symbol	OAZ1	YBX2
	Gene ID	4946	51087
	Gene name	ornithine decarboxylase antizyme 1	Y-box binding protein 2
	Synonyms	AZ1\|AZI\|OAZ	CONTRIN\|CSDA3\|DBPC\|MSY2
	Cytomap	19p13.3	17p13.1
	Type of gene	protein-coding	protein-coding
	Description	ornithine decarboxylase antizyme 1ODC-Azantizyme 1	Y-box-binding protein 2DNA-binding protein Cepididymis secretory sperm binding proteingerm cell specific Y-box binding protein
	Modification date	20200313	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000322297, ENST00000582888, ENST00000583542, ENST00000602676, ENST00000588673,	ENST00000570627, ENST00000007699,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	19 X 7 X 8=1064	6 X 4 X 5=120
	# samples	17	6
	** MAII score	log2(17/1064*10)=-2.64589149936349 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: OAZ1 [Title/Abstract] AND YBX2 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: OAZ1 [Title/Abstract] AND YBX2 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	OAZ1(2269743)-YBX2(7195378), # samples:3
Anticipated loss of major functional domain due to fusion event.	OAZ1-YBX2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. OAZ1-YBX2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. OAZ1-YBX2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. OAZ1-YBX2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	OAZ1	GO:0045732	positive regulation of protein catabolic process	17900240

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:2269743/chr17:7195378)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across OAZ1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across YBX2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000582888	OAZ1	chr19	2269743	+	ENST00000007699	YBX2	chr17	7195378	-	1450	259	89	1018	309
ENST00000602676	OAZ1	chr19	2269743	+	ENST00000007699	YBX2	chr17	7195378	-	1416	225	55	984	309
ENST00000322297	OAZ1	chr19	2269743	+	ENST00000007699	YBX2	chr17	7195378	-	1415	224	54	983	309
ENST00000583542	OAZ1	chr19	2269743	+	ENST00000007699	YBX2	chr17	7195378	-	1411	220	50	979	309

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000582888	ENST00000007699	OAZ1	chr19	2269743	+	YBX2	chr17	7195378	-	0.085237235	0.9147628
ENST00000602676	ENST00000007699	OAZ1	chr19	2269743	+	YBX2	chr17	7195378	-	0.080052786	0.91994727
ENST00000322297	ENST00000007699	OAZ1	chr19	2269743	+	YBX2	chr17	7195378	-	0.08108903	0.918911
ENST00000583542	ENST00000007699	OAZ1	chr19	2269743	+	YBX2	chr17	7195378	-	0.08078593	0.91921407

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for OAZ1-YBX2

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
OAZ1	chr19	2269743	YBX2	chr17	7195378	220	43	KPSATIHASRTMPLLSLHSRGGSSSE
OAZ1	chr19	2269743	YBX2	chr17	7195378	224	43	KPSATIHASRTMPLLSLHSRGGSSSE
OAZ1	chr19	2269743	YBX2	chr17	7195378	225	43	KPSATIHASRTMPLLSLHSRGGSSSE
OAZ1	chr19	2269743	YBX2	chr17	7195378	259	43	KPSATIHASRTMPLLSLHSRGGSSSE

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Potential FusionNeoAntigen Information of OAZ1-YBX2 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

OAZ1-YBX2_2269743_7195378.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B15:17	RTMPLLSL	0.9992	0.8941	9	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B15:16	RTMPLLSL	0.9986	0.7326	9	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-A30:08	RTMPLLSL	0.9842	0.7227	9	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:04	SRTMPLLSL	0.9999	0.7183	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:02	SRTMPLLSL	0.9999	0.5093	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:05	SRTMPLLSL	0.9999	0.7756	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B39:01	SRTMPLLSL	0.9995	0.923	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B39:06	SRTMPLLSL	0.9992	0.7229	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B38:02	SRTMPLLSL	0.9989	0.9626	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B39:01	IHASRTMPL	0.9988	0.8557	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B38:01	SRTMPLLSL	0.9988	0.9536	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B14:01	SRTMPLLSL	0.9983	0.6856	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B14:02	SRTMPLLSL	0.9983	0.6856	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B39:06	IHASRTMPL	0.9969	0.7706	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B38:02	IHASRTMPL	0.9954	0.9192	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B38:01	IHASRTMPL	0.9949	0.898	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B14:01	IHASRTMPL	0.9903	0.6079	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B14:02	IHASRTMPL	0.9903	0.6079	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-A30:08	RTMPLLSLH	0.9888	0.5727	9	18
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B15:10	IHASRTMPL	0.9814	0.5096	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B35:03	HASRTMPLL	0.9654	0.7905	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B15:16	RTMPLLSLH	0.9632	0.5985	9	18
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B15:37	IHASRTMPL	0.9305	0.5066	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B35:04	HASRTMPLL	0.8751	0.8547	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B35:02	HASRTMPLL	0.8751	0.8547	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B15:18	SRTMPLLSL	0.8196	0.6643	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B15:37	SRTMPLLSL	0.8176	0.6176	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B15:18	IHASRTMPL	0.8083	0.636	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:04	SRTMPLLSLH	0.9999	0.6971	8	18
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:05	SRTMPLLSLH	0.9999	0.8024	8	18
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:05	ASRTMPLLSL	0.9976	0.8282	7	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:02	ASRTMPLLSL	0.9975	0.514	7	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:04	ASRTMPLLSL	0.9972	0.7361	7	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B38:02	IHASRTMPLL	0.9931	0.9249	5	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B38:01	IHASRTMPLL	0.993	0.9051	5	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-A30:08	ASRTMPLLSL	0.9816	0.6852	7	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B39:01	TIHASRTMPL	0.7707	0.8715	4	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:07	HASRTMPLLSL	0.9988	0.5606	6	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-A74:03	RTMPLLSLHSR	0.9973	0.5772	9	20
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-A74:09	RTMPLLSLHSR	0.9973	0.5772	9	20
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-A74:11	RTMPLLSLHSR	0.9973	0.5772	9	20
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-A31:02	RTMPLLSLHSR	0.9918	0.5751	9	20
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-A30:08	RTMPLLSLHSR	0.9902	0.687	9	20
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C15:04	RTMPLLSL	1	0.9128	9	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C15:06	RTMPLLSL	0.9999	0.9468	9	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C03:08	RTMPLLSL	0.9996	0.9257	9	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:14	SRTMPLLSL	0.9999	0.7848	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C15:04	HASRTMPLL	0.9998	0.8009	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C03:19	HASRTMPLL	0.9997	0.9686	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C03:08	HASRTMPLL	0.9997	0.8516	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C15:06	HASRTMPLL	0.9997	0.8328	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C03:07	HASRTMPLL	0.9997	0.8987	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B39:09	SRTMPLLSL	0.9995	0.6262	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B39:12	SRTMPLLSL	0.9994	0.9283	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:95	SRTMPLLSL	0.9993	0.6547	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:05	SRTMPLLSL	0.9992	0.9665	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B39:09	IHASRTMPL	0.9989	0.5853	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:27	SRTMPLLSL	0.9989	0.9349	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B39:05	SRTMPLLSL	0.9987	0.9081	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:13	SRTMPLLSL	0.9986	0.8886	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B39:12	IHASRTMPL	0.9986	0.8595	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C04:06	HASRTMPLL	0.9984	0.8456	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:29	SRTMPLLSL	0.9984	0.9329	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:03	SRTMPLLSL	0.9973	0.8234	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C08:13	HASRTMPLL	0.9967	0.9068	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C08:04	HASRTMPLL	0.9967	0.9068	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B39:05	IHASRTMPL	0.9952	0.8452	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C03:14	HASRTMPLL	0.9872	0.9266	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C12:12	HASRTMPLL	0.9855	0.9052	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C06:03	HASRTMPLL	0.9848	0.974	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C12:04	HASRTMPLL	0.9845	0.9687	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C02:06	HASRTMPLL	0.9842	0.8945	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:46	SRTMPLLSL	0.9834	0.7835	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C08:03	HASRTMPLL	0.9667	0.9647	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C15:04	RTMPLLSLH	0.9647	0.9008	9	18
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B73:01	SRTMPLLSL	0.9577	0.6028	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:80	SRTMPLLSL	0.9463	0.8959	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:67	SRTMPLLSL	0.9463	0.8959	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:19	SRTMPLLSL	0.9189	0.6323	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:10	SRTMPLLSL	0.8796	0.9251	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B35:12	HASRTMPLL	0.8751	0.8547	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:13	IHASRTMPL	0.7701	0.8777	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:29	IHASRTMPL	0.7367	0.8918	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B14:03	IHASRTMPL	0.7197	0.7402	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:67	IHASRTMPL	0.698	0.908	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:80	IHASRTMPL	0.698	0.908	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B14:03	SRTMPLLSL	0.6841	0.7488	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:10	IHASRTMPL	0.6372	0.9246	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:46	IHASRTMPL	0.6297	0.8654	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B15:04	RTMPLLSLH	0.5322	0.7554	9	18
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C12:16	SRTMPLLSL	0.441	0.9475	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C12:16	IHASRTMPL	0.0506	0.9225	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:14	SRTMPLLSLH	0.9999	0.7962	8	18
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:03	SRTMPLLSLH	0.9992	0.8496	8	18
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B14:03	TIHASRTMPL	0.9686	0.7708	4	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:03	ASRTMPLLSL	0.9375	0.8597	7	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-A31:01	RTMPLLSLHSR	0.9973	0.5519	9	20
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C15:09	RTMPLLSL	1	0.9128	9	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C15:05	RTMPLLSL	0.9999	0.907	9	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C15:02	RTMPLLSL	0.9999	0.8877	9	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C16:02	RTMPLLSL	0.9996	0.9914	9	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C03:05	RTMPLLSL	0.9994	0.9102	9	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-A32:01	RTMPLLSL	0.9986	0.9503	9	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C16:01	HASRTMPL	0.9966	0.9605	6	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B07:13	RTMPLLSL	0.8646	0.8824	9	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:06	SRTMPLLSL	0.9999	0.6887	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:08	SRTMPLLSL	0.9999	0.7253	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:10	SRTMPLLSL	0.9999	0.8344	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C15:09	HASRTMPLL	0.9998	0.8009	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:09	SRTMPLLSL	0.9998	0.765	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C03:05	HASRTMPLL	0.9997	0.8906	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C15:05	HASRTMPLL	0.9996	0.8084	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C03:03	HASRTMPLL	0.9996	0.9711	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C03:04	HASRTMPLL	0.9996	0.9711	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C03:17	HASRTMPLL	0.9996	0.9396	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C15:02	HASRTMPLL	0.9995	0.7779	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B39:31	SRTMPLLSL	0.9995	0.9247	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B39:02	SRTMPLLSL	0.9994	0.9324	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:01	SRTMPLLSL	0.9993	0.626	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B38:05	SRTMPLLSL	0.9988	0.9536	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B39:31	IHASRTMPL	0.9987	0.8556	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C16:04	HASRTMPLL	0.9983	0.9504	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:17	SRTMPLLSL	0.9974	0.96	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B38:05	IHASRTMPL	0.9949	0.898	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C03:06	HASRTMPLL	0.9925	0.9698	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C06:08	SRTMPLLSL	0.9918	0.9773	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-A30:01	RTMPLLSLH	0.9905	0.7428	9	18
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C12:03	HASRTMPLL	0.9878	0.9468	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C16:01	HASRTMPLL	0.9867	0.9602	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C16:02	HASRTMPLL	0.9864	0.9781	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C02:10	HASRTMPLL	0.9795	0.9554	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C02:02	HASRTMPLL	0.9795	0.9554	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B58:06	RTMPLLSLH	0.9683	0.7317	9	18
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C08:01	HASRTMPLL	0.9667	0.9647	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C15:09	RTMPLLSLH	0.9647	0.9008	9	18
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B35:13	HASRTMPLL	0.9628	0.7995	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B07:13	HASRTMPLL	0.9604	0.8383	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:22	SRTMPLLSL	0.9587	0.7336	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B15:09	IHASRTMPL	0.9561	0.528	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B15:09	SRTMPLLSL	0.9542	0.5881	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:02	SRTMPLLSL	0.9463	0.8959	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:04	SRTMPLLSL	0.9178	0.9337	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B35:09	HASRTMPLL	0.8751	0.8547	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B39:11	SRTMPLLSL	0.8475	0.7629	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C17:01	HASRTMPLL	0.794	0.8542	6	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C03:67	SRTMPLLSL	0.784	0.9762	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:17	IHASRTMPL	0.7272	0.9334	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:02	IHASRTMPL	0.698	0.908	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C06:06	SRTMPLLSL	0.6464	0.9878	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B39:11	IHASRTMPL	0.607	0.6096	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C03:67	IHASRTMPL	0.5576	0.9419	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C07:04	IHASRTMPL	0.5528	0.8886	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C06:17	SRTMPLLSL	0.5385	0.9892	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C06:02	SRTMPLLSL	0.5385	0.9892	8	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-C06:06	IHASRTMPL	0.1985	0.9643	5	14
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:08	SRTMPLLSLH	0.9999	0.7082	8	18
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:10	SRTMPLLSLH	0.9999	0.8367	8	18
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:10	ASRTMPLLSL	0.9975	0.866	7	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:08	ASRTMPLLSL	0.997	0.7626	7	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:06	ASRTMPLLSL	0.9955	0.7406	7	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:09	ASRTMPLLSL	0.9946	0.8114	7	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B38:05	IHASRTMPLL	0.993	0.9051	5	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:06	HASRTMPLLSL	0.9997	0.7122	6	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:08	HASRTMPLLSL	0.9993	0.7194	6	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-B27:09	HASRTMPLLSL	0.9993	0.7642	6	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-A74:01	RTMPLLSLHSR	0.9973	0.5772	9	20
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	HLA-A30:01	RTMPLLSLHSR	0.9915	0.7944	9	20

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Potential FusionNeoAntigen Information of OAZ1-YBX2 in HLA II

OAZ1-YBX2_2269743_7195378.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0415	TMPLLSLHSRGGSSS	10	25
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0436	TMPLLSLHSRGGSSS	10	25
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0701	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0703	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0705	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0706	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0707	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0708	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0709	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0712	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0713	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0714	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0715	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0716	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0717	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0719	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0901	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0901	SATIHASRTMPLLSL	2	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0904	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0904	SATIHASRTMPLLSL	2	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0904	KPSATIHASRTMPLL	0	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0905	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0906	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0906	SATIHASRTMPLLSL	2	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0906	KPSATIHASRTMPLL	0	15
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0907	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0907	SATIHASRTMPLLSL	2	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0909	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-0909	SATIHASRTMPLLSL	2	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-1404	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-1410	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-1410	SATIHASRTMPLLSL	2	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-1428	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-1428	SATIHASRTMPLLSL	2	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-1439	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-1439	SATIHASRTMPLLSL	2	17
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-1450	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-1461	PSATIHASRTMPLLS	1	16
OAZ1-YBX2	chr19	2269743	chr17	7195378	224	DRB1-1471	PSATIHASRTMPLLS	1	16

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Fusion breakpoint peptide structures of OAZ1-YBX2

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
3278	HASRTMPLLSLHSR	OAZ1	YBX2	chr19	2269743	chr17	7195378	224

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of OAZ1-YBX2

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	3278	HASRTMPLLSLHSR	-7.9962	-8.1096
HLA-B14:02	3BVN	3278	HASRTMPLLSLHSR	-5.70842	-6.74372
HLA-B52:01	3W39	3278	HASRTMPLLSLHSR	-6.83737	-6.95077
HLA-B52:01	3W39	3278	HASRTMPLLSLHSR	-4.4836	-5.5189
HLA-A11:01	4UQ2	3278	HASRTMPLLSLHSR	-10.0067	-10.1201
HLA-A11:01	4UQ2	3278	HASRTMPLLSLHSR	-9.03915	-10.0745
HLA-A24:02	5HGA	3278	HASRTMPLLSLHSR	-6.56204	-6.67544
HLA-A24:02	5HGA	3278	HASRTMPLLSLHSR	-5.42271	-6.45801
HLA-B44:05	3DX8	3278	HASRTMPLLSLHSR	-7.85648	-8.89178
HLA-B44:05	3DX8	3278	HASRTMPLLSLHSR	-5.3978	-5.5112
HLA-A02:01	6TDR	3278	HASRTMPLLSLHSR	-3.37154	-4.40684

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Vaccine Design for the FusionNeoAntigens of OAZ1-YBX2

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
OAZ1-YBX2	chr19	2269743	chr17	7195378	4	14	TIHASRTMPL	CAGCCGCGGCGGCAGCAGCAGTGAGAGGAA
OAZ1-YBX2	chr19	2269743	chr17	7195378	5	14	IHASRTMPL	CCGCGGCGGCAGCAGCAGTGAGAGGAA
OAZ1-YBX2	chr19	2269743	chr17	7195378	5	15	IHASRTMPLL	CCGCGGCGGCAGCAGCAGTGAGAGGAATGA
OAZ1-YBX2	chr19	2269743	chr17	7195378	6	14	HASRTMPL	CGGCGGCAGCAGCAGTGAGAGGAA
OAZ1-YBX2	chr19	2269743	chr17	7195378	6	15	HASRTMPLL	CGGCGGCAGCAGCAGTGAGAGGAATGA
OAZ1-YBX2	chr19	2269743	chr17	7195378	6	17	HASRTMPLLSL	CGGCGGCAGCAGCAGTGAGAGGAATGACACCAA
OAZ1-YBX2	chr19	2269743	chr17	7195378	7	17	ASRTMPLLSL	CGGCAGCAGCAGTGAGAGGAATGACACCAA
OAZ1-YBX2	chr19	2269743	chr17	7195378	8	17	SRTMPLLSL	CAGCAGCAGTGAGAGGAATGACACCAA
OAZ1-YBX2	chr19	2269743	chr17	7195378	8	18	SRTMPLLSLH	CAGCAGCAGTGAGAGGAATGACACCAAGGA
OAZ1-YBX2	chr19	2269743	chr17	7195378	9	17	RTMPLLSL	CAGCAGTGAGAGGAATGACACCAA
OAZ1-YBX2	chr19	2269743	chr17	7195378	9	18	RTMPLLSLH	CAGCAGTGAGAGGAATGACACCAAGGA
OAZ1-YBX2	chr19	2269743	chr17	7195378	9	20	RTMPLLSLHSR	CAGCAGTGAGAGGAATGACACCAAGGAAGATGT

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
OAZ1-YBX2	chr19	2269743	chr17	7195378	0	15	KPSATIHASRTMPLL	CCTAAGCCTGCACAGCCGCGGCGGCAGCAGCAGTGAGAGGAATGA
OAZ1-YBX2	chr19	2269743	chr17	7195378	1	16	PSATIHASRTMPLLS	AAGCCTGCACAGCCGCGGCGGCAGCAGCAGTGAGAGGAATGACAC
OAZ1-YBX2	chr19	2269743	chr17	7195378	10	25	TMPLLSLHSRGGSSS	CAGTGAGAGGAATGACACCAAGGAAGATGTCTTTGTTCACCAGAC
OAZ1-YBX2	chr19	2269743	chr17	7195378	2	17	SATIHASRTMPLLSL	CCTGCACAGCCGCGGCGGCAGCAGCAGTGAGAGGAATGACACCAA

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Information of the samples that have these potential fusion neoantigens of OAZ1-YBX2

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
LIHC	OAZ1-YBX2	chr19	2269743	ENST00000322297	chr17	7195378	ENST00000007699	TCGA-BC-A10Y-01A

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Potential target of CAR-T therapy development for OAZ1-YBX2

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to OAZ1-YBX2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to OAZ1-YBX2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)