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Fusion Protein:OGDH-ZNF138

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: OGDH-ZNF138
	FusionPDB ID: 61405
	FusionGDB2.0 ID: 61405
		Hgene	Tgene
	Gene symbol	OGDH	ZNF138
	Gene ID	4967	7697
	Gene name	oxoglutarate dehydrogenase	zinc finger protein 138
	Synonyms	AKGDH\|E1k\|OGDC	pHZ-32
	Cytomap	7p13	7q11.21
	Type of gene	protein-coding	protein-coding
	Description	2-oxoglutarate dehydrogenase, mitochondrial2-oxoglutarate dehydrogenase complex component E1OGDC-E1oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)oxoglutarate decarboxylaseoxoglutarate dehydrogenase (succinyl-transferring)testicular tis	zinc finger protein 138zinc finger protein 138 (clone pHZ-32)
	Modification date	20200313	20200320
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000222673, ENST00000439616, ENST00000443864, ENST00000444676, ENST00000447398, ENST00000449767, ENST00000543843, ENST00000459672,	ENST00000397136, ENST00000430838, ENST00000437743, ENST00000440598, ENST00000440155, ENST00000494380, ENST00000307355, ENST00000359735,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 5 X 3=105	5 X 3 X 4=60
	# samples	7	5
	** MAII score	log2(7/105*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: OGDH [Title/Abstract] AND ZNF138 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: OGDH [Title/Abstract] AND ZNF138 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	OGDH(44664164)-ZNF138(64291829), # samples:1
Anticipated loss of major functional domain due to fusion event.	OGDH-ZNF138 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. OGDH-ZNF138 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. OGDH-ZNF138 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. OGDH-ZNF138 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. OGDH-ZNF138 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	OGDH	GO:0006103	2-oxoglutarate metabolic process	24495017\|29211711
Hgene	OGDH	GO:0006104	succinyl-CoA metabolic process	24495017\|29211711
Hgene	OGDH	GO:0106077	histone succinylation	29211711

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:44664164/chr7:64291829)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across OGDH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZNF138 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000439616	OGDH	chr7	44664164	+	ENST00000307355	ZNF138	chr7	64291829	+	1083	331	333	1082	249
ENST00000439616	OGDH	chr7	44664164	+	ENST00000359735	ZNF138	chr7	64291829	+	2529	331	333	1082	249
ENST00000443864	OGDH	chr7	44664164	+	ENST00000307355	ZNF138	chr7	64291829	+	1067	315	317	1066	250
ENST00000443864	OGDH	chr7	44664164	+	ENST00000359735	ZNF138	chr7	64291829	+	2513	315	317	1066	249
ENST00000447398	OGDH	chr7	44664164	+	ENST00000307355	ZNF138	chr7	64291829	+	1064	312	314	1063	250
ENST00000447398	OGDH	chr7	44664164	+	ENST00000359735	ZNF138	chr7	64291829	+	2510	312	314	1063	249
ENST00000449767	OGDH	chr7	44664164	+	ENST00000307355	ZNF138	chr7	64291829	+	1064	312	314	1063	250
ENST00000449767	OGDH	chr7	44664164	+	ENST00000359735	ZNF138	chr7	64291829	+	2510	312	314	1063	249
ENST00000444676	OGDH	chr7	44664164	+	ENST00000307355	ZNF138	chr7	64291829	+	1027	275	277	1026	250
ENST00000444676	OGDH	chr7	44664164	+	ENST00000359735	ZNF138	chr7	64291829	+	2473	275	277	1026	249
ENST00000222673	OGDH	chr7	44664164	+	ENST00000307355	ZNF138	chr7	64291829	+	1016	264	266	1015	250
ENST00000222673	OGDH	chr7	44664164	+	ENST00000359735	ZNF138	chr7	64291829	+	2462	264	266	1015	249
ENST00000543843	OGDH	chr7	44664164	+	ENST00000307355	ZNF138	chr7	64291829	+	856	104	106	855	250
ENST00000543843	OGDH	chr7	44664164	+	ENST00000359735	ZNF138	chr7	64291829	+	2302	104	106	855	249

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000439616	ENST00000307355	OGDH	chr7	44664164	+	ZNF138	chr7	64291829	+	0.11697002	0.88302994
ENST00000439616	ENST00000359735	OGDH	chr7	44664164	+	ZNF138	chr7	64291829	+	0.35232067	0.6476793
ENST00000443864	ENST00000307355	OGDH	chr7	44664164	+	ZNF138	chr7	64291829	+	0.18371186	0.8162882
ENST00000443864	ENST00000359735	OGDH	chr7	44664164	+	ZNF138	chr7	64291829	+	0.51930964	0.48069033
ENST00000447398	ENST00000307355	OGDH	chr7	44664164	+	ZNF138	chr7	64291829	+	0.15397519	0.8460249
ENST00000447398	ENST00000359735	OGDH	chr7	44664164	+	ZNF138	chr7	64291829	+	0.410499	0.589501
ENST00000449767	ENST00000307355	OGDH	chr7	44664164	+	ZNF138	chr7	64291829	+	0.15397519	0.8460249
ENST00000449767	ENST00000359735	OGDH	chr7	44664164	+	ZNF138	chr7	64291829	+	0.410499	0.589501
ENST00000444676	ENST00000307355	OGDH	chr7	44664164	+	ZNF138	chr7	64291829	+	0.17709005	0.82290995
ENST00000444676	ENST00000359735	OGDH	chr7	44664164	+	ZNF138	chr7	64291829	+	0.54326755	0.45673248
ENST00000222673	ENST00000307355	OGDH	chr7	44664164	+	ZNF138	chr7	64291829	+	0.1822338	0.8177662
ENST00000222673	ENST00000359735	OGDH	chr7	44664164	+	ZNF138	chr7	64291829	+	0.5938797	0.40612027
ENST00000543843	ENST00000307355	OGDH	chr7	44664164	+	ZNF138	chr7	64291829	+	0.44059452	0.5594055
ENST00000543843	ENST00000359735	OGDH	chr7	44664164	+	ZNF138	chr7	64291829	+	0.6920179	0.30798206

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for OGDH-ZNF138

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
OGDH	chr7	44664164	ZNF138	chr7	64291829	104	80	IFQCNKYVKVMHKFSNSNRHKIRHTE
OGDH	chr7	44664164	ZNF138	chr7	64291829	264	80	IFQCNKYVKVMHKFSNSNRHKIRHTE
OGDH	chr7	44664164	ZNF138	chr7	64291829	275	80	IFQCNKYVKVMHKFSNSNRHKIRHTE
OGDH	chr7	44664164	ZNF138	chr7	64291829	312	80	IFQCNKYVKVMHKFSNSNRHKIRHTE
OGDH	chr7	44664164	ZNF138	chr7	64291829	315	80	IFQCNKYVKVMHKFSNSNRHKIRHTE
OGDH	chr7	44664164	ZNF138	chr7	64291829	331	80	IFQCNKYVKVMHKFSNSNRHKIRHTE

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Potential FusionNeoAntigen Information of OGDH-ZNF138 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

OGDH-ZNF138_44664164_64291829.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-A32:13	KYVKVMHKF	0.9508	0.8749	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-A30:08	KVMHKFSNS	0.9439	0.554	8	17
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-B58:02	KYVKVMHKF	0.0648	0.8076	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C07:19	KYVKVMHKF	0.5056	0.5733	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C07:67	KYVKVMHKF	0.3523	0.8784	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C07:80	KYVKVMHKF	0.3523	0.8784	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C07:29	KYVKVMHKF	0.3447	0.9055	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C07:95	KYVKVMHKF	0.3091	0.553	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C07:10	KYVKVMHKF	0.3064	0.8949	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C07:46	KYVKVMHKF	0.2724	0.7786	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C07:27	KYVKVMHKF	0.2723	0.8959	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C07:05	KYVKVMHKF	0.2462	0.8698	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C07:13	KYVKVMHKF	0.2141	0.8735	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C12:16	KYVKVMHKF	0.0077	0.9176	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C02:02	YVKVMHKF	0.941	0.9512	6	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C02:10	YVKVMHKF	0.941	0.9512	6	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-A30:01	KFSNSNRHK	0.9697	0.7187	12	21
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-A32:01	KYVKVMHKF	0.8081	0.8914	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C07:01	KYVKVMHKF	0.3843	0.5485	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C07:22	KYVKVMHKF	0.363	0.5922	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C07:02	KYVKVMHKF	0.3523	0.8784	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C07:17	KYVKVMHKF	0.3399	0.9168	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-B58:06	KYVKVMHKF	0.0768	0.5953	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C03:67	KYVKVMHKF	0.014	0.9668	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C06:17	KYVKVMHKF	0.0112	0.9863	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C06:02	KYVKVMHKF	0.0112	0.9863	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C14:02	KYVKVMHKF	0.0112	0.8695	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C14:03	KYVKVMHKF	0.0112	0.8695	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C06:06	KYVKVMHKF	0.0053	0.9642	5	14
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	HLA-C04:04	KYVKVMHKF	0.0013	0.8139	5	14

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Potential FusionNeoAntigen Information of OGDH-ZNF138 in HLA II

OGDH-ZNF138_44664164_64291829.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-0804	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-0820	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-0820	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-0828	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-0828	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-0831	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-0831	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1103	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1104	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1104	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1105	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1106	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1106	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1111	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1111	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1114	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1114	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1118	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1118	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1120	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1120	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1125	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1125	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1132	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1134	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1135	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1135	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1138	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1138	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1141	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1142	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1142	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1143	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1143	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1144	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1144	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1146	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1146	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1147	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1147	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1148	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1150	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1150	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1153	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1154	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1154	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1156	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1156	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1157	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1157	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1158	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1158	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1160	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1160	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1163	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1167	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1167	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1168	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1168	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1172	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1176	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1177	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1177	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1178	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1178	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1183	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1184	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1184	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1185	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1186	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1188	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1188	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1192	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1192	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1204	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1204	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1209	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1209	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1302	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1302	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1306	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1306	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1308	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1309	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1311	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1311	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1316	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1318	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1318	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1319	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1323	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1323	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1324	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1326	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1326	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1329	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1329	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1331	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1331	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1331	KVMHKFSNSNRHKIR	8	23
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1331	HKFSNSNRHKIRHTE	11	26
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1334	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1334	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1336	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1336	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1338	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1338	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1339	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1339	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1341	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1341	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1342	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1342	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1344	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1353	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1363	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1363	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1365	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1365	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1370	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1372	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1373	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1373	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1374	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1374	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1384	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1396	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1396	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1397	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1397	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1399	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1399	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1406	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1406	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1407	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1407	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1407	KVMHKFSNSNRHKIR	8	23
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1407	HKFSNSNRHKIRHTE	11	26
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1412	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1412	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1414	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1414	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1414	KVMHKFSNSNRHKIR	8	23
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1415	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1417	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1420	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1420	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1427	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1429	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1429	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1436	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1436	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1436	KVMHKFSNSNRHKIR	8	23
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1437	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1442	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1442	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1442	KVMHKFSNSNRHKIR	8	23
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1442	HKFSNSNRHKIRHTE	11	26
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1444	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1444	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1444	KVMHKFSNSNRHKIR	8	23
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1452	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1468	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1468	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1478	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1478	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1480	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1481	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1483	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1483	CNKYVKVMHKFSNSN	3	18
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1484	NKYVKVMHKFSNSNR	4	19
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1493	MHKFSNSNRHKIRHT	10	25
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB1-1493	VMHKFSNSNRHKIRH	9	24
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB5-0106	VKVMHKFSNSNRHKI	7	22
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB5-0106	YVKVMHKFSNSNRHK	6	21
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB5-0202	VKVMHKFSNSNRHKI	7	22
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB5-0202	YVKVMHKFSNSNRHK	6	21
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB5-0204	VKVMHKFSNSNRHKI	7	22
OGDH-ZNF138	chr7	44664164	chr7	64291829	264	DRB5-0204	YVKVMHKFSNSNRHK	6	21

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Fusion breakpoint peptide structures of OGDH-ZNF138

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
10845	YVKVMHKFSNSNRH	OGDH	ZNF138	chr7	44664164	chr7	64291829	264

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of OGDH-ZNF138

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	10845	YVKVMHKFSNSNRH	-7.9962	-8.1096
HLA-B14:02	3BVN	10845	YVKVMHKFSNSNRH	-5.70842	-6.74372
HLA-B52:01	3W39	10845	YVKVMHKFSNSNRH	-6.83737	-6.95077
HLA-B52:01	3W39	10845	YVKVMHKFSNSNRH	-4.4836	-5.5189
HLA-A11:01	4UQ2	10845	YVKVMHKFSNSNRH	-10.0067	-10.1201
HLA-A11:01	4UQ2	10845	YVKVMHKFSNSNRH	-9.03915	-10.0745
HLA-A24:02	5HGA	10845	YVKVMHKFSNSNRH	-6.56204	-6.67544
HLA-A24:02	5HGA	10845	YVKVMHKFSNSNRH	-5.42271	-6.45801
HLA-B44:05	3DX8	10845	YVKVMHKFSNSNRH	-7.85648	-8.89178
HLA-B44:05	3DX8	10845	YVKVMHKFSNSNRH	-5.3978	-5.5112
HLA-A02:01	6TDR	10845	YVKVMHKFSNSNRH	-3.37154	-4.40684

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Vaccine Design for the FusionNeoAntigens of OGDH-ZNF138

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
OGDH-ZNF138	chr7	44664164	chr7	64291829	12	21	KFSNSNRHK	AAGCTCTGTGTTCTCGTTTTGCCCAAG
OGDH-ZNF138	chr7	44664164	chr7	64291829	5	14	KYVKVMHKF	GAAAACCCCAAAAGTGTACATAAGCTC
OGDH-ZNF138	chr7	44664164	chr7	64291829	6	14	YVKVMHKF	AACCCCAAAAGTGTACATAAGCTC
OGDH-ZNF138	chr7	44664164	chr7	64291829	8	17	KVMHKFSNS	AAAAGTGTACATAAGCTCTGTGTTCTC

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
OGDH-ZNF138	chr7	44664164	chr7	64291829	10	25	MHKFSNSNRHKIRHT	GTACATAAGCTCTGTGTTCTCGTTTTGCCCAAGACCTTTGGCTAG
OGDH-ZNF138	chr7	44664164	chr7	64291829	11	26	HKFSNSNRHKIRHTE	CATAAGCTCTGTGTTCTCGTTTTGCCCAAGACCTTTGGCTAGAGC
OGDH-ZNF138	chr7	44664164	chr7	64291829	3	18	CNKYVKVMHKFSNSN	TGGCTGGAAAACCCCAAAAGTGTACATAAGCTCTGTGTTCTCGTT
OGDH-ZNF138	chr7	44664164	chr7	64291829	4	19	NKYVKVMHKFSNSNR	CTGGAAAACCCCAAAAGTGTACATAAGCTCTGTGTTCTCGTTTTG
OGDH-ZNF138	chr7	44664164	chr7	64291829	6	21	YVKVMHKFSNSNRHK	AACCCCAAAAGTGTACATAAGCTCTGTGTTCTCGTTTTGCCCAAG
OGDH-ZNF138	chr7	44664164	chr7	64291829	7	22	VKVMHKFSNSNRHKI	CCCAAAAGTGTACATAAGCTCTGTGTTCTCGTTTTGCCCAAGACC
OGDH-ZNF138	chr7	44664164	chr7	64291829	8	23	KVMHKFSNSNRHKIR	AAAAGTGTACATAAGCTCTGTGTTCTCGTTTTGCCCAAGACCTTT
OGDH-ZNF138	chr7	44664164	chr7	64291829	9	24	VMHKFSNSNRHKIRH	AGTGTACATAAGCTCTGTGTTCTCGTTTTGCCCAAGACCTTTGGC

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Information of the samples that have these potential fusion neoantigens of OGDH-ZNF138

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
Non-Cancer	OGDH-ZNF138	chr7	44664164	ENST00000222673	chr7	64291829	ENST00000307355	TCGA-BH-A1EV-11A

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Potential target of CAR-T therapy development for OGDH-ZNF138

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to OGDH-ZNF138

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to OGDH-ZNF138

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)