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Fusion Protein:PBRM1-FBXW12

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PBRM1-FBXW12
	FusionPDB ID: 63000
	FusionGDB2.0 ID: 63000
		Hgene	Tgene
	Gene symbol	PBRM1	FBXW12
	Gene ID	55193	285231
	Gene name	polybromo 1	F-box and WD repeat domain containing 12
	Synonyms	BAF180\|PB1	FBW12\|FBXO12\|FBXO35
	Cytomap	3p21.1	3p21.31
	Type of gene	protein-coding	protein-coding
	Description	protein polybromo-1BRG1-associated factor 180polybromo-1D	F-box/WD repeat-containing protein 12F-box and WD-40 domain protein 12F-box and WD-40 domain-containing protein 12F-box only protein 35F-box- and WD40-repeat-containing protein
	Modification date	20200313	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000296302, ENST00000337303, ENST00000356770, ENST00000394830, ENST00000409057, ENST00000409114, ENST00000409767, ENST00000410007,	ENST00000436231, ENST00000468158, ENST00000296438, ENST00000415155, ENST00000445170,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	15 X 15 X 10=2250	5 X 5 X 5=125
	# samples	19	8
	** MAII score	log2(19/2250*10)=-3.56585367777345 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/125*10)=-0.643856189774725 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: PBRM1 [Title/Abstract] AND FBXW12 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: PBRM1 [Title/Abstract] AND FBXW12 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PBRM1(52592265)-FBXW12(48416844), # samples:1 PBRM1(52595783)-FBXW12(48416844), # samples:1
Anticipated loss of major functional domain due to fusion event.	PBRM1-FBXW12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PBRM1-FBXW12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PBRM1-FBXW12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PBRM1-FBXW12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PBRM1-FBXW12 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. PBRM1-FBXW12 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. PBRM1-FBXW12 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PBRM1-FBXW12 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PBRM1-FBXW12 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52592265/chr3:48416844)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across PBRM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FBXW12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000296302	PBRM1	chr3	52592265	-	ENST00000296438	FBXW12	chr3	48416844	+	5630	4455	2	5563	1853
ENST00000296302	PBRM1	chr3	52592265	-	ENST00000415155	FBXW12	chr3	48416844	+	5382	4455	2	5353	1783
ENST00000296302	PBRM1	chr3	52592265	-	ENST00000445170	FBXW12	chr3	48416844	+	5592	4455	2	5563	1853
ENST00000409114	PBRM1	chr3	52592265	-	ENST00000296438	FBXW12	chr3	48416844	+	5676	4501	3	5609	1868
ENST00000409114	PBRM1	chr3	52592265	-	ENST00000415155	FBXW12	chr3	48416844	+	5428	4501	3	5399	1798
ENST00000409114	PBRM1	chr3	52592265	-	ENST00000445170	FBXW12	chr3	48416844	+	5638	4501	3	5609	1868
ENST00000356770	PBRM1	chr3	52595783	-	ENST00000296438	FBXW12	chr3	48416844	+	5370	4195	3	5303	1766
ENST00000356770	PBRM1	chr3	52595783	-	ENST00000415155	FBXW12	chr3	48416844	+	5122	4195	3	5093	1696
ENST00000356770	PBRM1	chr3	52595783	-	ENST00000445170	FBXW12	chr3	48416844	+	5332	4195	3	5303	1766
ENST00000296302	PBRM1	chr3	52595783	-	ENST00000296438	FBXW12	chr3	48416844	+	5465	4290	2	5398	1798
ENST00000296302	PBRM1	chr3	52595783	-	ENST00000415155	FBXW12	chr3	48416844	+	5217	4290	2	5188	1728
ENST00000296302	PBRM1	chr3	52595783	-	ENST00000445170	FBXW12	chr3	48416844	+	5427	4290	2	5398	1798
ENST00000337303	PBRM1	chr3	52595783	-	ENST00000296438	FBXW12	chr3	48416844	+	5466	4291	3	5399	1798
ENST00000337303	PBRM1	chr3	52595783	-	ENST00000415155	FBXW12	chr3	48416844	+	5218	4291	3	5189	1728
ENST00000337303	PBRM1	chr3	52595783	-	ENST00000445170	FBXW12	chr3	48416844	+	5428	4291	3	5399	1798
ENST00000410007	PBRM1	chr3	52595783	-	ENST00000296438	FBXW12	chr3	48416844	+	5391	4216	3	5324	1773
ENST00000410007	PBRM1	chr3	52595783	-	ENST00000415155	FBXW12	chr3	48416844	+	5143	4216	3	5114	1703
ENST00000410007	PBRM1	chr3	52595783	-	ENST00000445170	FBXW12	chr3	48416844	+	5353	4216	3	5324	1773
ENST00000409057	PBRM1	chr3	52595783	-	ENST00000296438	FBXW12	chr3	48416844	+	5466	4291	3	5399	1798
ENST00000409057	PBRM1	chr3	52595783	-	ENST00000415155	FBXW12	chr3	48416844	+	5218	4291	3	5189	1728
ENST00000409057	PBRM1	chr3	52595783	-	ENST00000445170	FBXW12	chr3	48416844	+	5428	4291	3	5399	1798
ENST00000409114	PBRM1	chr3	52595783	-	ENST00000296438	FBXW12	chr3	48416844	+	5511	4336	3	5444	1813
ENST00000409114	PBRM1	chr3	52595783	-	ENST00000415155	FBXW12	chr3	48416844	+	5263	4336	3	5234	1743
ENST00000409114	PBRM1	chr3	52595783	-	ENST00000445170	FBXW12	chr3	48416844	+	5473	4336	3	5444	1813
ENST00000409767	PBRM1	chr3	52595783	-	ENST00000296438	FBXW12	chr3	48416844	+	5511	4336	3	5444	1813
ENST00000409767	PBRM1	chr3	52595783	-	ENST00000415155	FBXW12	chr3	48416844	+	5263	4336	3	5234	1743
ENST00000409767	PBRM1	chr3	52595783	-	ENST00000445170	FBXW12	chr3	48416844	+	5473	4336	3	5444	1813

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000296302	ENST00000296438	PBRM1	chr3	52592265	-	FBXW12	chr3	48416844	+	0.000883589	0.99911636
ENST00000296302	ENST00000415155	PBRM1	chr3	52592265	-	FBXW12	chr3	48416844	+	0.000795565	0.99920446
ENST00000296302	ENST00000445170	PBRM1	chr3	52592265	-	FBXW12	chr3	48416844	+	0.000868513	0.9991315
ENST00000409114	ENST00000296438	PBRM1	chr3	52592265	-	FBXW12	chr3	48416844	+	0.000922169	0.9990778
ENST00000409114	ENST00000415155	PBRM1	chr3	52592265	-	FBXW12	chr3	48416844	+	0.000836043	0.999164
ENST00000409114	ENST00000445170	PBRM1	chr3	52592265	-	FBXW12	chr3	48416844	+	0.00090692	0.99909306
ENST00000356770	ENST00000296438	PBRM1	chr3	52595783	-	FBXW12	chr3	48416844	+	0.000621872	0.9993781
ENST00000356770	ENST00000415155	PBRM1	chr3	52595783	-	FBXW12	chr3	48416844	+	0.00045141	0.9995486
ENST00000356770	ENST00000445170	PBRM1	chr3	52595783	-	FBXW12	chr3	48416844	+	0.000609044	0.99939096
ENST00000296302	ENST00000296438	PBRM1	chr3	52595783	-	FBXW12	chr3	48416844	+	0.000657788	0.99934214
ENST00000296302	ENST00000415155	PBRM1	chr3	52595783	-	FBXW12	chr3	48416844	+	0.000475948	0.9995241
ENST00000296302	ENST00000445170	PBRM1	chr3	52595783	-	FBXW12	chr3	48416844	+	0.000644816	0.99935514
ENST00000337303	ENST00000296438	PBRM1	chr3	52595783	-	FBXW12	chr3	48416844	+	0.000663073	0.9993369
ENST00000337303	ENST00000415155	PBRM1	chr3	52595783	-	FBXW12	chr3	48416844	+	0.000480761	0.9995192
ENST00000337303	ENST00000445170	PBRM1	chr3	52595783	-	FBXW12	chr3	48416844	+	0.000650048	0.9993499
ENST00000410007	ENST00000296438	PBRM1	chr3	52595783	-	FBXW12	chr3	48416844	+	0.000519946	0.99948007
ENST00000410007	ENST00000415155	PBRM1	chr3	52595783	-	FBXW12	chr3	48416844	+	0.00037126	0.99962866
ENST00000410007	ENST00000445170	PBRM1	chr3	52595783	-	FBXW12	chr3	48416844	+	0.000506142	0.99949384
ENST00000409057	ENST00000296438	PBRM1	chr3	52595783	-	FBXW12	chr3	48416844	+	0.000663073	0.9993369
ENST00000409057	ENST00000415155	PBRM1	chr3	52595783	-	FBXW12	chr3	48416844	+	0.000480761	0.9995192
ENST00000409057	ENST00000445170	PBRM1	chr3	52595783	-	FBXW12	chr3	48416844	+	0.000650048	0.9993499
ENST00000409114	ENST00000296438	PBRM1	chr3	52595783	-	FBXW12	chr3	48416844	+	0.000682045	0.999318
ENST00000409114	ENST00000415155	PBRM1	chr3	52595783	-	FBXW12	chr3	48416844	+	0.000495043	0.9995049
ENST00000409114	ENST00000445170	PBRM1	chr3	52595783	-	FBXW12	chr3	48416844	+	0.00066735	0.9993326
ENST00000409767	ENST00000296438	PBRM1	chr3	52595783	-	FBXW12	chr3	48416844	+	0.000682045	0.999318
ENST00000409767	ENST00000415155	PBRM1	chr3	52595783	-	FBXW12	chr3	48416844	+	0.000495043	0.9995049
ENST00000409767	ENST00000445170	PBRM1	chr3	52595783	-	FBXW12	chr3	48416844	+	0.00066735	0.9993326

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for PBRM1-FBXW12

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
PBRM1	chr3	52592265	FBXW12	chr3	48416844	4455	1484	PMGMLNQQLTPVAAFETELAYLSGNR
PBRM1	chr3	52592265	FBXW12	chr3	48416844	4501	1499	PMGMLNQQLTPVAAFETELAYLSGNR
PBRM1	chr3	52595783	FBXW12	chr3	48416844	4195	1397	WRNLETAKKAEYEAFETELAYLSGNR
PBRM1	chr3	52595783	FBXW12	chr3	48416844	4216	1404	WRNLETAKKAEYEAFETELAYLSGNR
PBRM1	chr3	52595783	FBXW12	chr3	48416844	4290	1429	WRNLETAKKAEYEAFETELAYLSGNR
PBRM1	chr3	52595783	FBXW12	chr3	48416844	4291	1429	WRNLETAKKAEYEAFETELAYLSGNR
PBRM1	chr3	52595783	FBXW12	chr3	48416844	4336	1444	WRNLETAKKAEYEAFETELAYLSGNR

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Potential FusionNeoAntigen Information of PBRM1-FBXW12 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

PBRM1-FBXW12_52592265_48416844.msa
PBRM1-FBXW12_52595783_48416844.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:25	AAFETELAY	0.9988	0.9703	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:01	AAFETELAY	0.9983	0.9509	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:01	QQLTPVAAF	0.998	0.9836	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:08	AAFETELAY	0.9975	0.9114	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:02	AAFETELAY	0.9967	0.9743	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:01	AAFETELAY	0.9956	0.9331	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:17	AAFETELAY	0.9945	0.963	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:25	QQLTPVAAF	0.9526	0.9897	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:02	QQLTPVAAF	0.9507	0.9906	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B48:01	QQLTPVAAF	0.9324	0.858	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:03	QQLTPVAAF	0.9209	0.9731	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:16	AAFETELAY	0.9077	0.9155	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B53:01	AAFETELAY	0.906	0.5325	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B39:06	NQQLTPVAA	0.9043	0.9593	5	14
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:03	AAFETELAY	0.9018	0.9004	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:18	QQLTPVAAF	0.8712	0.9559	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:05	AAFETELAY	0.8575	0.7247	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:18	AAFETELAY	0.8408	0.8382	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B50:01	NQQLTPVAA	0.8305	0.8432	5	14
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B47:01	QQLTPVAAF	0.8298	0.7047	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B58:02	AAFETELAY	0.7359	0.9773	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B39:13	QQLTPVAAF	0.6561	0.9915	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:10	QQLTPVAAF	0.6398	0.8926	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B40:05	QQLTPVAAF	0.6377	0.6201	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B13:01	QQLTPVAAF	0.5812	0.998	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:37	QQLTPVAAF	0.4298	0.8996	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-A24:14	QQLTPVAAF	0.4051	0.7607	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-A32:13	QQLTPVAAF	0.3673	0.9902	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B47:01	AAFETELAY	0.3263	0.7148	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B46:01	QQLTPVAAF	0.3041	0.9027	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:04	AAFETELAY	0.2842	0.9744	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:02	AAFETELAY	0.2842	0.9744	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B07:10	QQLTPVAAF	0.1466	0.5351	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B52:01	QQLTPVAAF	0.0728	0.9981	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:25	VAAFETELAY	0.9979	0.9697	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:02	VAAFETELAY	0.9935	0.9752	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:08	VAAFETELAY	0.9932	0.8811	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:01	VAAFETELAY	0.9869	0.9265	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:03	TPVAAFETEL	0.9795	0.9439	9	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:02	TPVAAFETEL	0.9235	0.98	9	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:04	TPVAAFETEL	0.9235	0.98	9	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:05	VAAFETELAY	0.88	0.6694	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B81:01	TPVAAFETEL	0.8327	0.7796	9	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B82:01	TPVAAFETEL	0.5789	0.6449	9	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C03:19	VAAFETEL	0.9999	0.9956	11	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C08:13	VAAFETEL	0.99	0.9851	11	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C08:04	VAAFETEL	0.99	0.9851	11	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C08:03	VAAFETEL	0.877	0.9903	11	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:05	AAFETELAY	0.9986	0.9308	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:21	AAFETELAY	0.997	0.9556	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:31	AAFETELAY	0.9965	0.9381	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:07	AAFETELAY	0.9887	0.8247	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:07	QQLTPVAAF	0.9816	0.9022	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:04	QQLTPVAAF	0.9675	0.9887	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:21	QQLTPVAAF	0.9477	0.9834	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C15:04	AAFETELAY	0.9287	0.9667	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C07:19	AAFETELAY	0.8956	0.8406	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:05	QQLTPVAAF	0.8939	0.9611	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:31	QQLTPVAAF	0.8874	0.9651	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B40:03	QQLTPVAAF	0.8862	0.7241	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C12:16	AAFETELAY	0.8432	0.9788	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C07:10	AAFETELAY	0.8358	0.9846	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C07:95	AAFETELAY	0.8177	0.7649	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C07:80	AAFETELAY	0.8164	0.9711	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C07:67	AAFETELAY	0.8164	0.9711	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C07:27	AAFETELAY	0.7454	0.9665	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C07:46	AAFETELAY	0.7317	0.9418	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:04	AAFETELAY	0.7138	0.9659	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B48:03	QQLTPVAAF	0.6611	0.9431	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B39:05	NQQLTPVAA	0.5957	0.9877	5	14
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B39:08	QQLTPVAAF	0.5829	0.984	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C03:14	AAFETELAY	0.4545	0.9877	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C07:05	AAFETELAY	0.4519	0.9759	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B44:08	QQLTPVAAF	0.4493	0.8581	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C12:12	AAFETELAY	0.4441	0.9615	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C12:04	AAFETELAY	0.3787	0.9959	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C06:03	AAFETELAY	0.3771	0.9962	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:12	AAFETELAY	0.2842	0.9744	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B44:10	QQLTPVAAF	0.2765	0.972	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:05	VAAFETELAY	0.9946	0.9105	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:21	VAAFETELAY	0.9938	0.9588	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:31	VAAFETELAY	0.9873	0.9182	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B07:12	TPVAAFETEL	0.9523	0.6793	9	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B56:04	TPVAAFETEL	0.9267	0.6068	9	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:12	TPVAAFETEL	0.9235	0.98	9	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B39:10	TPVAAFETEL	0.824	0.9625	9	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B42:01	TPVAAFETEL	0.6845	0.7942	9	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B54:01	TPVAAFETELA	0.9958	0.7578	9	20
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C03:03	VAAFETEL	0.9999	0.9944	11	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C03:04	VAAFETEL	0.9999	0.9944	11	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C16:01	VAAFETEL	0.9882	0.9827	11	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B07:13	VAAFETEL	0.914	0.8467	11	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C08:01	VAAFETEL	0.877	0.9903	11	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:20	AAFETELAY	0.9986	0.9591	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:39	AAFETELAY	0.9986	0.9374	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:27	AAFETELAY	0.9984	0.96	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:33	AAFETELAY	0.9983	0.9509	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:34	AAFETELAY	0.9983	0.9509	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:125	AAFETELAY	0.9983	0.9509	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:135	AAFETELAY	0.9982	0.9513	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:28	AAFETELAY	0.998	0.9611	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:34	QQLTPVAAF	0.998	0.9836	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:135	QQLTPVAAF	0.998	0.9857	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:125	QQLTPVAAF	0.998	0.9836	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:33	QQLTPVAAF	0.998	0.9836	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:27	QQLTPVAAF	0.9979	0.9851	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:24	QQLTPVAAF	0.9973	0.993	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:11	AAFETELAY	0.9962	0.9509	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:11	AAFETELAY	0.996	0.9231	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:20	AAFETELAY	0.9958	0.9636	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:77	AAFETELAY	0.9956	0.9331	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:50	AAFETELAY	0.9953	0.953	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:23	AAFETELAY	0.9951	0.9319	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:08	AAFETELAY	0.9951	0.9236	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:53	AAFETELAY	0.9944	0.9418	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:43	AAFETELAY	0.9937	0.9237	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:50	QQLTPVAAF	0.9931	0.9847	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:24	AAFETELAY	0.9895	0.9719	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:35	QQLTPVAAF	0.9887	0.9611	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:35	AAFETELAY	0.9814	0.9546	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:12	AAFETELAY	0.9796	0.9154	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:12	QQLTPVAAF	0.9782	0.9654	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C03:02	AAFETELAY	0.9754	0.9809	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:53	QQLTPVAAF	0.9747	0.983	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:24	AAFETELAY	0.9658	0.9281	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:17	AAFETELAY	0.9554	0.877	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:30	AAFETELAY	0.9554	0.877	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:39	QQLTPVAAF	0.953	0.979	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:13	AAFETELAY	0.9478	0.9227	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C15:09	AAFETELAY	0.9287	0.9667	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B18:11	AAFETELAY	0.9027	0.9278	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:20	QQLTPVAAF	0.8965	0.9752	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:54	QQLTPVAAF	0.8762	0.9787	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:28	QQLTPVAAF	0.8679	0.978	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B58:06	AAFETELAY	0.8653	0.9689	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:20	QQLTPVAAF	0.8614	0.9787	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B48:02	AAFETELAY	0.8508	0.9537	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C07:17	AAFETELAY	0.8501	0.9775	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B40:40	QQLTPVAAF	0.8465	0.7048	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:13	QQLTPVAAF	0.8435	0.9918	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:13	AAFETELAY	0.8371	0.9385	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:73	QQLTPVAAF	0.8346	0.9662	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B50:05	NQQLTPVAA	0.8305	0.8432	5	14
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B50:04	NQQLTPVAA	0.8305	0.8432	5	14
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C07:01	AAFETELAY	0.8279	0.7477	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:54	AAFETELAY	0.8194	0.9284	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C07:02	AAFETELAY	0.8164	0.9711	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B39:02	QQLTPVAAF	0.8084	0.9909	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C12:02	AAFETELAY	0.7983	0.9809	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:68	QQLTPVAAF	0.7965	0.8796	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B18:11	QQLTPVAAF	0.7917	0.9521	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B48:02	QQLTPVAAF	0.7823	0.97	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B40:21	QQLTPVAAF	0.6678	0.9368	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:30	QQLTPVAAF	0.6631	0.9873	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B40:12	QQLTPVAAF	0.6611	0.9431	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B18:04	QQLTPVAAF	0.6356	0.962	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-A32:01	QQLTPVAAF	0.6343	0.9902	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C16:04	AAFETELAY	0.6294	0.986	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:68	AAFETELAY	0.6256	0.7352	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B53:02	AAFETELAY	0.6163	0.6515	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B18:07	QQLTPVAAF	0.5726	0.9413	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B40:49	QQLTPVAAF	0.5304	0.9448	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C12:03	AAFETELAY	0.5296	0.9826	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B18:08	QQLTPVAAF	0.5077	0.9664	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-A25:01	AAFETELAY	0.492	0.9179	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B18:04	AAFETELAY	0.4299	0.9322	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C16:01	AAFETELAY	0.3493	0.9813	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:09	QQLTPVAAF	0.3174	0.9547	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:09	NQQLTPVAA	0.3108	0.8483	5	14
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:09	AAFETELAY	0.2842	0.9744	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B48:05	QQLTPVAAF	0.2698	0.5289	6	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C16:02	AAFETELAY	0.186	0.9935	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B18:03	AAFETELAY	0.1658	0.9081	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B18:07	AAFETELAY	0.1645	0.875	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B18:08	AAFETELAY	0.1413	0.8988	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B18:06	AAFETELAY	0.1312	0.9212	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C02:02	AAFETELAY	0.1186	0.9872	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C02:10	AAFETELAY	0.1186	0.9872	12	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:39	VAAFETELAY	0.9974	0.9372	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:20	VAAFETELAY	0.9948	0.9498	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:11	VAAFETELAY	0.9929	0.9548	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:28	VAAFETELAY	0.9923	0.9557	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:11	VAAFETELAY	0.9889	0.9166	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C03:02	VAAFETELAY	0.9884	0.983	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:08	VAAFETELAY	0.9879	0.9178	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:77	VAAFETELAY	0.9869	0.9265	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:20	VAAFETELAY	0.9854	0.9571	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:23	VAAFETELAY	0.9853	0.9329	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:43	VAAFETELAY	0.9838	0.9167	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B15:12	NQQLTPVAAF	0.9809	0.8384	5	15
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:24	VAAFETELAY	0.9463	0.924	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:22	TPVAAFETEL	0.9447	0.743	9	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:17	VAAFETELAY	0.9402	0.8561	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:30	VAAFETELAY	0.9402	0.8561	11	21
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-C17:01	AAFETELAYL	0.9395	0.9696	12	22
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B55:04	TPVAAFETEL	0.9303	0.714	9	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:13	AAFETELAYL	0.927	0.9191	12	22
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B56:02	TPVAAFETEL	0.9267	0.6068	9	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B35:09	TPVAAFETEL	0.9235	0.98	9	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B07:26	TPVAAFETEL	0.8903	0.6414	9	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B67:01	TPVAAFETEL	0.8234	0.9474	9	19
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	HLA-B82:02	TPVAAFETEL	0.5789	0.6449	9	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B50:02	AEYEAFET	0.9999	0.673	9	17
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:01	YEAFETEL	0.9947	0.9759	11	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B39:13	YEAFETEL	0.9752	0.9366	11	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B50:01	AEYEAFET	0.9368	0.7651	9	17
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:08	EAFETELAY	0.9979	0.854	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:01	EAFETELAY	0.991	0.9171	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:02	EAFETELAY	0.9884	0.9658	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:25	EAFETELAY	0.9861	0.9601	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B45:01	YEAFETELA	0.9724	0.9398	11	20
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B45:01	AEYEAFETE	0.9689	0.9391	9	18
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B50:02	YEAFETELA	0.9384	0.7339	11	20
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B50:02	AEYEAFETE	0.9264	0.6631	9	18
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:05	EAFETELAY	0.7255	0.6711	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:03	EAFETELAY	0.6206	0.9391	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:18	EAFETELAY	0.556	0.7816	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:03	EAFETELAY	0.5066	0.8358	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B50:01	YEAFETELA	0.3718	0.7328	11	20
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:01	EAFETELAY	0.3462	0.9084	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:03	AKKAEYEAF	0.3144	0.8944	6	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B41:01	YEAFETELA	0.3023	0.8837	11	20
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:04	EAFETELAY	0.2357	0.9634	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:02	EAFETELAY	0.2357	0.9634	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B50:01	AEYEAFETE	0.0659	0.7599	9	18
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B44:03	AEYEAFETEL	0.9952	0.983	9	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B47:01	AEYEAFETEL	0.9935	0.7402	9	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:01	YEAFETELAY	0.9933	0.9503	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B13:01	AEYEAFETEL	0.9926	0.9293	9	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B50:02	AEYEAFETEL	0.9915	0.645	9	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B44:03	YEAFETELAY	0.9909	0.9782	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:01	YEAFETELAY	0.9882	0.9401	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B47:01	YEAFETELAY	0.9666	0.6494	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:25	YEAFETELAY	0.9535	0.9506	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:08	YEAFETELAY	0.9491	0.8616	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B45:01	AEYEAFETEL	0.9399	0.8873	9	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:01	YEAFETELAY	0.9383	0.9175	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B39:13	AEYEAFETEL	0.9351	0.9576	9	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:03	EAFETELAYL	0.9322	0.9142	12	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B50:01	AEYEAFETEL	0.9287	0.735	9	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:02	YEAFETELAY	0.9267	0.9605	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:02	EAFETELAYL	0.8722	0.9584	12	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:04	EAFETELAYL	0.8722	0.9584	12	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:05	YEAFETELAY	0.8216	0.627	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B41:01	AEYEAFETEL	0.7824	0.9235	9	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:03	YEAFETELAY	0.7714	0.8259	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:18	YEAFETELAY	0.6967	0.7663	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B50:02	AEYEAFETELA	0.9995	0.7599	9	20
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B45:01	AEYEAFETELA	0.9994	0.9344	9	20
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B50:01	AEYEAFETELA	0.9945	0.7887	9	20
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:08	EYEAFETELAY	0.9755	0.8766	10	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B41:01	AEYEAFETELA	0.9711	0.8853	9	20
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:01	EYEAFETELAY	0.9625	0.9185	10	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:02	EYEAFETELAY	0.9605	0.9607	10	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:05	EYEAFETELAY	0.9538	0.6418	10	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B40:06	AEYEAFET	0.9999	0.666	9	17
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B39:08	YEAFETEL	0.9873	0.7821	11	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:31	EAFETELAY	0.9925	0.9288	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:21	EAFETELAY	0.9887	0.9356	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B40:06	YEAFETELA	0.9872	0.5988	11	20
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:05	EAFETELAY	0.9851	0.9183	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C04:10	EYEAFETEL	0.9833	0.7442	10	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C04:07	EYEAFETEL	0.9817	0.7406	10	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B40:06	AEYEAFETE	0.9774	0.6571	9	18
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C04:14	EYEAFETEL	0.4715	0.7638	10	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C15:04	EAFETELAY	0.3432	0.9308	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:12	EAFETELAY	0.2357	0.9634	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C12:12	EAFETELAY	0.1548	0.9681	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C03:14	EAFETELAY	0.143	0.9862	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C12:04	EAFETELAY	0.0366	0.9955	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C06:03	EAFETELAY	0.0328	0.9958	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B40:06	AEYEAFETEL	0.9996	0.6525	9	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B39:08	AEYEAFETEL	0.9693	0.8165	9	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:05	YEAFETELAY	0.96	0.9143	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:31	YEAFETELAY	0.9426	0.9264	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:21	YEAFETELAY	0.9096	0.9265	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:12	EAFETELAYL	0.8722	0.9584	12	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C15:04	YEAFETELAY	0.8526	0.9229	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C03:14	YEAFETELAY	0.841	0.9806	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C12:12	YEAFETELAY	0.7504	0.9524	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B40:06	AEYEAFETELA	0.9997	0.6438	9	20
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:31	EYEAFETELAY	0.9613	0.9315	10	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:21	EYEAFETELAY	0.9608	0.9277	10	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B40:04	YEAFETEL	0.9998	0.7075	11	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:05	YEAFETEL	0.9947	0.9759	11	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:03	YEAFETEL	0.9938	0.9728	11	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:08	YEAFETEL	0.9935	0.9529	11	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:06	YEAFETEL	0.9928	0.9783	11	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B39:11	YEAFETEL	0.991	0.7654	11	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:11	YEAFETEL	0.9789	0.9476	11	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B39:02	YEAFETEL	0.977	0.9428	11	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B50:05	AEYEAFET	0.9368	0.7651	9	17
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B50:04	AEYEAFET	0.9368	0.7651	9	17
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B41:03	YEAFETEL	0.9317	0.5289	11	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-A25:01	EAFETELAY	0.996	0.8972	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:77	EAFETELAY	0.991	0.9171	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:20	EAFETELAY	0.9902	0.9639	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:23	EAFETELAY	0.9885	0.9104	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:24	EAFETELAY	0.9885	0.9293	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:11	EAFETELAY	0.9867	0.9258	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:39	EAFETELAY	0.9857	0.895	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C04:01	EYEAFETEL	0.9817	0.7406	10	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:20	EAFETELAY	0.981	0.9602	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:28	EAFETELAY	0.975	0.9601	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C18:01	EYEAFETEL	0.9717	0.748	10	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:13	EAFETELAY	0.8969	0.6206	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:11	EAFETELAY	0.896	0.8874	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:08	EAFETELAY	0.8936	0.8924	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:43	EAFETELAY	0.8672	0.8953	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C03:02	EAFETELAY	0.8405	0.976	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:30	EAFETELAY	0.84	0.8302	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:17	EAFETELAY	0.84	0.8302	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:04	EAFETELAY	0.7409	0.9219	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:12	EAFETELAY	0.7289	0.8878	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C04:04	EYEAFETEL	0.6927	0.8544	10	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:11	EAFETELAY	0.6782	0.9137	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B39:11	EYEAFETEL	0.6288	0.7482	10	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B48:02	EAFETELAY	0.6167	0.954	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:53	EAFETELAY	0.5694	0.9226	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C12:02	EAFETELAY	0.4356	0.9806	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:07	EAFETELAY	0.4103	0.8709	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B50:04	YEAFETELA	0.3718	0.7328	11	20
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B50:05	YEAFETELA	0.3718	0.7328	11	20
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:03	EAFETELAY	0.3669	0.8988	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:08	EAFETELAY	0.3593	0.8595	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:06	EAFETELAY	0.3502	0.9175	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:05	EAFETELAY	0.3462	0.9084	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C15:09	EAFETELAY	0.3432	0.9308	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:09	EAFETELAY	0.2357	0.9634	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:53	AKKAEYEAF	0.2094	0.9218	6	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:54	AKKAEYEAF	0.1967	0.913	6	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C16:04	EAFETELAY	0.1804	0.9914	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:68	AKKAEYEAF	0.1473	0.7923	6	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C12:03	EAFETELAY	0.1472	0.9883	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B48:02	AKKAEYEAF	0.1243	0.9739	6	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C16:01	EAFETELAY	0.0668	0.9775	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B50:05	AEYEAFETE	0.0659	0.7599	9	18
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B50:04	AEYEAFETE	0.0659	0.7599	9	18
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B78:02	EAFETELAY	0.061	0.5124	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C02:02	EAFETELAY	0.0398	0.9876	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C02:10	EAFETELAY	0.0398	0.9876	12	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B40:04	AEYEAFETEL	0.9988	0.7393	9	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:04	YEAFETELAY	0.9963	0.9561	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B44:26	AEYEAFETEL	0.9952	0.983	9	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B44:07	AEYEAFETEL	0.9952	0.983	9	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B44:13	AEYEAFETEL	0.9952	0.983	9	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:07	YEAFETELAY	0.995	0.9248	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-A68:02	EAFETELAYL	0.9942	0.5534	12	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:05	YEAFETELAY	0.9933	0.9503	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:08	YEAFETELAY	0.9929	0.9012	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B44:13	YEAFETELAY	0.9909	0.9782	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B44:07	YEAFETELAY	0.9909	0.9782	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B44:26	YEAFETELAY	0.9909	0.9782	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:125	YEAFETELAY	0.9882	0.9401	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:33	YEAFETELAY	0.9882	0.9401	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:34	YEAFETELAY	0.9882	0.9401	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:27	YEAFETELAY	0.9878	0.9458	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:53	AEYEAFETEL	0.9855	0.9463	9	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:11	YEAFETELAY	0.9845	0.8842	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:06	YEAFETELAY	0.9833	0.9529	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:03	YEAFETELAY	0.9824	0.9442	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:08	YEAFETELAY	0.9802	0.8939	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-A69:01	EAFETELAYL	0.9774	0.6551	12	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:43	YEAFETELAY	0.9743	0.8937	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:53	YEAFETELAY	0.9617	0.9263	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:20	YEAFETELAY	0.961	0.9536	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:28	YEAFETELAY	0.9515	0.9528	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:39	YEAFETELAY	0.9507	0.893	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:24	YEAFETELAY	0.9456	0.9487	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:11	YEAFETELAY	0.9441	0.9091	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:12	YEAFETELAY	0.9393	0.9302	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:77	YEAFETELAY	0.9383	0.9175	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:23	YEAFETELAY	0.9346	0.9093	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B50:04	AEYEAFETEL	0.9287	0.735	9	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B50:05	AEYEAFETEL	0.9287	0.735	9	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:20	YEAFETELAY	0.9275	0.9579	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B39:02	AEYEAFETEL	0.9265	0.9592	9	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:11	YEAFETELAY	0.9182	0.9202	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:54	YEAFETELAY	0.9007	0.904	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C12:02	YEAFETELAY	0.8841	0.9777	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B41:03	AEYEAFETEL	0.8764	0.5822	9	19
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:09	EAFETELAYL	0.8722	0.9584	12	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C15:09	YEAFETELAY	0.8526	0.9229	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:30	YEAFETELAY	0.8477	0.8136	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:17	YEAFETELAY	0.8477	0.8136	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C03:02	YEAFETELAY	0.8401	0.9738	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C16:04	YEAFETELAY	0.8117	0.9889	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C02:10	YEAFETELAY	0.7437	0.9875	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C02:02	YEAFETELAY	0.7437	0.9875	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-C12:03	YEAFETELAY	0.7388	0.987	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B48:02	YEAFETELAY	0.7371	0.9432	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:13	YEAFETELAY	0.7357	0.6157	11	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B50:04	AEYEAFETELA	0.9945	0.7887	9	20
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B50:05	AEYEAFETELA	0.9945	0.7887	9	20
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:08	EYEAFETELAY	0.9759	0.8813	10	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B15:11	EYEAFETELAY	0.9732	0.8702	10	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:43	EYEAFETELAY	0.9719	0.8828	10	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:11	EYEAFETELAY	0.9666	0.9183	10	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:24	EYEAFETELAY	0.9649	0.9369	10	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:17	EYEAFETELAY	0.9631	0.8262	10	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:30	EYEAFETELAY	0.9631	0.8262	10	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:77	EYEAFETELAY	0.9625	0.9185	10	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:23	EYEAFETELAY	0.9624	0.9102	10	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:04	EYEAFETELAY	0.9606	0.9596	10	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B35:20	EYEAFETELAY	0.9535	0.9563	10	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-B18:07	EYEAFETELAY	0.9248	0.9296	10	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	HLA-A25:01	EYEAFETELAY	0.7011	0.8561	10	21

Top

Potential FusionNeoAntigen Information of PBRM1-FBXW12 in HLA II

PBRM1-FBXW12_52592265_48416844.msa
PBRM1-FBXW12_52595783_48416844.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	DRB1-0455	LTPVAAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	DRB1-0456	LTPVAAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52592265	chr3	48416844	4455	DRB1-0473	LTPVAAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0113	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0115	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0401	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0401	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0401	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0407	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0407	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0407	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0417	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0419	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0419	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0419	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0424	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0424	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0424	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0431	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0431	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0431	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0433	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0433	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0433	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0434	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0435	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0435	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0435	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0438	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0438	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0438	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0443	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0443	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0443	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0447	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0447	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0454	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0454	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0461	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0461	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0461	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0462	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0462	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0462	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0463	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0463	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0463	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0464	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0464	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0464	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0469	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0469	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0469	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0472	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0474	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0474	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0474	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0475	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0475	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0475	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0476	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0476	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0476	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0480	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0482	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0482	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0482	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0486	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0486	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0486	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-0902	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1001	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1003	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1134	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1343	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1344	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1354	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1371	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1376	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1377	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1404	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1411	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1417	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1418	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1421	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1428	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1433	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1435	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1450	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1461	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1464	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1470	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1471	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1472	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1482	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1495	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1495	RNLETAKKAEYEAFE	1	16
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1499	WRNLETAKKAEYEAF	0	15
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1502	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1502	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1502	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1508	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1508	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1508	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1511	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1511	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1511	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1514	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1514	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1514	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1515	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1515	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1515	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1519	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1519	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1519	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1526	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1526	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1526	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1527	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1527	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1527	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1529	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1529	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1529	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1530	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1530	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1530	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1531	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1531	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1531	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1534	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1534	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1534	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1538	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1538	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1538	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1539	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1539	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1539	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1544	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1544	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1544	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1547	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1547	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1547	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1601	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1601	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1601	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1602	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1602	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1602	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1603	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1603	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1603	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1604	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1604	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1604	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1605	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1605	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1605	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1607	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1607	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1607	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1608	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1608	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1608	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1609	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1609	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1609	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1610	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1610	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1610	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1611	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1611	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1611	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1612	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1612	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1612	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1614	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1614	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1614	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1616	KAEYEAFETELAYLS	8	23
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1616	KKAEYEAFETELAYL	7	22
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB1-1616	AKKAEYEAFETELAY	6	21
PBRM1-FBXW12	chr3	52595783	chr3	48416844	4290	DRB5-0203	KAEYEAFETELAYLS	8	23

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Fusion breakpoint peptide structures of PBRM1-FBXW12

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
317	AKKAEYEAFETELA	PBRM1	FBXW12	chr3	52595783	chr3	48416844	4290

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
7509	QQLTPVAAFETELA	PBRM1	FBXW12	chr3	52592265	chr3	48416844	4455

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of PBRM1-FBXW12

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B53:01	1A1O	317	AKKAEYEAFETELA	-2.521	-3.5563
HLA-B51:01	1E28	317	AKKAEYEAFETELA	-1.92936	-2.96466
HLA-B57:03	2BVO	317	AKKAEYEAFETELA	-3.93412	-4.04752
HLA-A03:01	2XPG	317	AKKAEYEAFETELA	-4.06211	-4.17551
HLA-B14:02	3BVN	317	AKKAEYEAFETELA	-5.90915	-6.02255
HLA-B14:02	3BVN	317	AKKAEYEAFETELA	-3.14094	-4.17624
HLA-B27:09	3CZF	317	AKKAEYEAFETELA	10001	10000
HLA-B44:03	3DX7	317	AKKAEYEAFETELA	-0.694336	-1.72964
HLA-B52:01	3W39	317	AKKAEYEAFETELA	-5.17909	-5.29249
HLA-B52:01	3W39	317	AKKAEYEAFETELA	-3.78069	-4.81599
HLA-B18:01	4JQV	317	AKKAEYEAFETELA	-3.7903	-4.8256
HLA-B18:01	4JQV	317	AKKAEYEAFETELA	-2.32734	-2.44074
HLA-A11:01	4UQ2	317	AKKAEYEAFETELA	-9.23212	-9.34552
HLA-A11:01	4UQ2	317	AKKAEYEAFETELA	-8.48766	-9.52296
HLA-A24:02	5HGA	317	AKKAEYEAFETELA	-7.36197	-7.47537
HLA-A24:02	5HGA	317	AKKAEYEAFETELA	-3.3994	-4.4347
HLA-B57:01	5VUD	317	AKKAEYEAFETELA	-2.43326	-3.46856
HLA-B27:05	6PYJ	317	AKKAEYEAFETELA	-4.63681	-4.75021
HLA-B27:05	6PYJ	317	AKKAEYEAFETELA	-2.95711	-3.99241
HLA-B27:03	6PZ5	317	AKKAEYEAFETELA	-1.99721	-3.03251
HLA-B27:03	6PZ5	317	AKKAEYEAFETELA	-1.21669	-1.33009
HLA-B44:05	3DX8	317	AKKAEYEAFETELA	-4.55876	-4.67216
HLA-B44:05	3DX8	317	AKKAEYEAFETELA	-4.48915	-5.52445
HLA-B07:02	5EO0	317	AKKAEYEAFETELA	-1.42589	-2.46119
HLA-A02:01	6TDR	317	AKKAEYEAFETELA	-2.39029	-3.42559
HLA-B14:02	3BVN	7509	QQLTPVAAFETELA	-7.15543	-7.26883
HLA-B14:02	3BVN	7509	QQLTPVAAFETELA	-4.77435	-5.80965
HLA-B52:01	3W39	7509	QQLTPVAAFETELA	-6.80875	-6.92215
HLA-B52:01	3W39	7509	QQLTPVAAFETELA	-4.20386	-5.23916
HLA-A11:01	4UQ2	7509	QQLTPVAAFETELA	-7.5194	-8.5547
HLA-A11:01	4UQ2	7509	QQLTPVAAFETELA	-6.9601	-7.0735
HLA-A24:02	5HGA	7509	QQLTPVAAFETELA	-7.52403	-7.63743
HLA-A24:02	5HGA	7509	QQLTPVAAFETELA	-5.82433	-6.85963
HLA-B27:05	6PYJ	7509	QQLTPVAAFETELA	-3.28285	-4.31815
HLA-B44:05	3DX8	7509	QQLTPVAAFETELA	-5.91172	-6.94702
HLA-B44:05	3DX8	7509	QQLTPVAAFETELA	-4.24346	-4.35686

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Vaccine Design for the FusionNeoAntigens of PBRM1-FBXW12

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
PBRM1-FBXW12	chr3	52592265	chr3	48416844	11	19	VAAFETEL	TTGCAGCATTTGAGACGGAGTTGG
PBRM1-FBXW12	chr3	52592265	chr3	48416844	11	21	VAAFETELAY	TTGCAGCATTTGAGACGGAGTTGGCTTATC
PBRM1-FBXW12	chr3	52592265	chr3	48416844	12	21	AAFETELAY	CAGCATTTGAGACGGAGTTGGCTTATC
PBRM1-FBXW12	chr3	52592265	chr3	48416844	12	22	AAFETELAYL	CAGCATTTGAGACGGAGTTGGCTTATCTCT
PBRM1-FBXW12	chr3	52592265	chr3	48416844	5	14	NQQLTPVAA	ATCAGCAGTTGACACCTGTTGCAGCAT
PBRM1-FBXW12	chr3	52592265	chr3	48416844	5	15	NQQLTPVAAF	ATCAGCAGTTGACACCTGTTGCAGCATTTG
PBRM1-FBXW12	chr3	52592265	chr3	48416844	6	15	QQLTPVAAF	AGCAGTTGACACCTGTTGCAGCATTTG
PBRM1-FBXW12	chr3	52592265	chr3	48416844	9	19	TPVAAFETEL	CACCTGTTGCAGCATTTGAGACGGAGTTGG
PBRM1-FBXW12	chr3	52592265	chr3	48416844	9	20	TPVAAFETELA	CACCTGTTGCAGCATTTGAGACGGAGTTGGCTT
PBRM1-FBXW12	chr3	52595783	chr3	48416844	10	19	EYEAFETEL	AATATGAAGCATTTGAGACGGAGTTGG
PBRM1-FBXW12	chr3	52595783	chr3	48416844	10	21	EYEAFETELAY	AATATGAAGCATTTGAGACGGAGTTGGCTTATC
PBRM1-FBXW12	chr3	52595783	chr3	48416844	11	19	YEAFETEL	ATGAAGCATTTGAGACGGAGTTGG
PBRM1-FBXW12	chr3	52595783	chr3	48416844	11	20	YEAFETELA	ATGAAGCATTTGAGACGGAGTTGGCTT
PBRM1-FBXW12	chr3	52595783	chr3	48416844	11	21	YEAFETELAY	ATGAAGCATTTGAGACGGAGTTGGCTTATC
PBRM1-FBXW12	chr3	52595783	chr3	48416844	12	21	EAFETELAY	AAGCATTTGAGACGGAGTTGGCTTATC
PBRM1-FBXW12	chr3	52595783	chr3	48416844	12	22	EAFETELAYL	AAGCATTTGAGACGGAGTTGGCTTATCTCT
PBRM1-FBXW12	chr3	52595783	chr3	48416844	6	15	AKKAEYEAF	CCAAGAAAGCAGAATATGAAGCATTTG
PBRM1-FBXW12	chr3	52595783	chr3	48416844	9	17	AEYEAFET	CAGAATATGAAGCATTTGAGACGG
PBRM1-FBXW12	chr3	52595783	chr3	48416844	9	18	AEYEAFETE	CAGAATATGAAGCATTTGAGACGGAGT
PBRM1-FBXW12	chr3	52595783	chr3	48416844	9	19	AEYEAFETEL	CAGAATATGAAGCATTTGAGACGGAGTTGG
PBRM1-FBXW12	chr3	52595783	chr3	48416844	9	20	AEYEAFETELA	CAGAATATGAAGCATTTGAGACGGAGTTGGCTT

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
PBRM1-FBXW12	chr3	52592265	chr3	48416844	8	23	LTPVAAFETELAYLS	TGACACCTGTTGCAGCATTTGAGACGGAGTTGGCTTATCTCTCAG
PBRM1-FBXW12	chr3	52595783	chr3	48416844	0	15	WRNLETAKKAEYEAF	GGAGAAATCTTGAGACAGCCAAGAAAGCAGAATATGAAGCATTTG
PBRM1-FBXW12	chr3	52595783	chr3	48416844	1	16	RNLETAKKAEYEAFE	GAAATCTTGAGACAGCCAAGAAAGCAGAATATGAAGCATTTGAGA
PBRM1-FBXW12	chr3	52595783	chr3	48416844	6	21	AKKAEYEAFETELAY	CCAAGAAAGCAGAATATGAAGCATTTGAGACGGAGTTGGCTTATC
PBRM1-FBXW12	chr3	52595783	chr3	48416844	7	22	KKAEYEAFETELAYL	AGAAAGCAGAATATGAAGCATTTGAGACGGAGTTGGCTTATCTCT
PBRM1-FBXW12	chr3	52595783	chr3	48416844	8	23	KAEYEAFETELAYLS	AAGCAGAATATGAAGCATTTGAGACGGAGTTGGCTTATCTCTCAG

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Information of the samples that have these potential fusion neoantigens of PBRM1-FBXW12

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
MESO	PBRM1-FBXW12	chr3	52592265	ENST00000296302	chr3	48416844	ENST00000296438	TCGA-MQ-A4LM-01A
MESO	PBRM1-FBXW12	chr3	52595783	ENST00000296302	chr3	48416844	ENST00000296438	TCGA-MQ-A4LM-01A

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Potential target of CAR-T therapy development for PBRM1-FBXW12

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to PBRM1-FBXW12

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to PBRM1-FBXW12

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)