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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:PPP2R4-MUSK

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PPP2R4-MUSK
FusionPDB ID: 68053
FusionGDB2.0 ID: 68053
HgeneTgene
Gene symbol

PPP2R4

MUSK

Gene ID

5524

4593

Gene nameprotein phosphatase 2 phosphatase activatormuscle associated receptor tyrosine kinase
SynonymsPP2A|PPP2R4|PR53CMS9|FADS|FADS1
Cytomap

9q34.11

9q31.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2A activatorPP2A phosphatase activatorPP2A subunit B' isoform PR53phosphotyrosyl phosphatase activatorprotein phosphatase 2 regulatory subunit 4protein phosphatase 2A activator, regulatory subunit 4protein phosphmuscle, skeletal receptor tyrosine-protein kinasemuscle, skeletal, receptor tyrosine kinasemuscle-specific kinase receptormuscle-specific tyrosine-protein kinase receptor
Modification date2020032920200313
UniProtAcc.

O15146

Main function of 5'-partner protein: FUNCTION: Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:25537362}.
Ensembl transtripts involved in fusion geneENST idsENST00000337738, ENST00000347048, 
ENST00000348141, ENST00000355007, 
ENST00000357197, ENST00000358994, 
ENST00000393370, ENST00000414510, 
ENST00000419582, ENST00000423100, 
ENST00000432124, ENST00000432651, 
ENST00000434095, ENST00000435132, 
ENST00000435305, ENST00000436883, 
ENST00000452489, ENST00000524946, 
ENST00000374438, ENST00000374439, 
ENST00000374440, ENST00000189978, 
ENST00000374448, ENST00000416899, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 9 X 8=7205 X 6 X 2=60
# samples 127
** MAII scorelog2(12/720*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Fusion gene context

PubMed: PPP2R4 [Title/Abstract] AND MUSK [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: PPP2R4 [Title/Abstract] AND MUSK [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PPP2R4(131904831)-MUSK(113509921), # samples:1
Anticipated loss of major functional domain due to fusion event.PPP2R4-MUSK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP2R4-MUSK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP2R4-MUSK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP2R4-MUSK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP2R4-MUSK seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PPP2R4-MUSK seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PPP2R4-MUSK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PPP2R4-MUSK seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP2R4

GO:0032515

negative regulation of phosphoprotein phosphatase activity

16916641

HgenePPP2R4

GO:0032516

positive regulation of phosphoprotein phosphatase activity

16916641

HgenePPP2R4

GO:0035307

positive regulation of protein dephosphorylation

16916641

HgenePPP2R4

GO:0035308

negative regulation of protein dephosphorylation

16916641

HgenePPP2R4

GO:0043065

positive regulation of apoptotic process

17333320

HgenePPP2R4

GO:0043666

regulation of phosphoprotein phosphatase activity

16916641

TgeneMUSK

GO:0007528

neuromuscular junction development

25537362



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:131904831/chr9:113509921)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across PPP2R4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MUSK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000358994PPP2R4chr9131904831+ENST00000189978MUSKchr9113509921+2973110682962984
ENST00000358994PPP2R4chr9131904831+ENST00000374448MUSKchr9113509921+2973110682962984
ENST00000358994PPP2R4chr9131904831+ENST00000416899MUSKchr9113509921+3530110682938976
ENST00000393370PPP2R4chr9131904831+ENST00000189978MUSKchr9113509921+304411771693033954
ENST00000393370PPP2R4chr9131904831+ENST00000374448MUSKchr9113509921+304411771693033954
ENST00000393370PPP2R4chr9131904831+ENST00000416899MUSKchr9113509921+360111771693009946
ENST00000337738PPP2R4chr9131904831+ENST00000189978MUSKchr9113509921+313312661533122989
ENST00000337738PPP2R4chr9131904831+ENST00000374448MUSKchr9113509921+313312661533122989
ENST00000337738PPP2R4chr9131904831+ENST00000416899MUSKchr9113509921+369012661533098981
ENST00000348141PPP2R4chr9131904831+ENST00000189978MUSKchr9113509921+304411771513033960
ENST00000348141PPP2R4chr9131904831+ENST00000374448MUSKchr9113509921+304411771513033960
ENST00000348141PPP2R4chr9131904831+ENST00000416899MUSKchr9113509921+360111771513009952
ENST00000452489PPP2R4chr9131904831+ENST00000189978MUSKchr9113509921+30791212993068989
ENST00000452489PPP2R4chr9131904831+ENST00000374448MUSKchr9113509921+30791212993068989
ENST00000452489PPP2R4chr9131904831+ENST00000416899MUSKchr9113509921+36361212993044981
ENST00000357197PPP2R4chr9131904831+ENST00000189978MUSKchr9113509921+2866999782855925
ENST00000357197PPP2R4chr9131904831+ENST00000374448MUSKchr9113509921+2866999782855925
ENST00000357197PPP2R4chr9131904831+ENST00000416899MUSKchr9113509921+3423999782831917
ENST00000347048PPP2R4chr9131904831+ENST00000189978MUSKchr9113509921+2296429782285735
ENST00000347048PPP2R4chr9131904831+ENST00000374448MUSKchr9113509921+2296429782285735
ENST00000347048PPP2R4chr9131904831+ENST00000416899MUSKchr9113509921+2853429782261727
ENST00000355007PPP2R4chr9131904831+ENST00000189978MUSKchr9113509921+2822955732811912
ENST00000355007PPP2R4chr9131904831+ENST00000374448MUSKchr9113509921+2822955732811912
ENST00000355007PPP2R4chr9131904831+ENST00000416899MUSKchr9113509921+3379955732787904
ENST00000423100PPP2R4chr9131904831+ENST00000189978MUSKchr9113509921+22433762652232655
ENST00000423100PPP2R4chr9131904831+ENST00000374448MUSKchr9113509921+22433762652232655
ENST00000423100PPP2R4chr9131904831+ENST00000416899MUSKchr9113509921+28003762652208647
ENST00000524946PPP2R4chr9131904831+ENST00000189978MUSKchr9113509921+2963109610362952638
ENST00000524946PPP2R4chr9131904831+ENST00000374448MUSKchr9113509921+2963109610362952638
ENST00000524946PPP2R4chr9131904831+ENST00000416899MUSKchr9113509921+3520109610362928630
ENST00000436883PPP2R4chr9131904831+ENST00000189978MUSKchr9113509921+211925292108699
ENST00000436883PPP2R4chr9131904831+ENST00000374448MUSKchr9113509921+211925292108699
ENST00000436883PPP2R4chr9131904831+ENST00000416899MUSKchr9113509921+267625292084691
ENST00000414510PPP2R4chr9131904831+ENST00000189978MUSKchr9113509921+211925292108699
ENST00000414510PPP2R4chr9131904831+ENST00000374448MUSKchr9113509921+211925292108699
ENST00000414510PPP2R4chr9131904831+ENST00000416899MUSKchr9113509921+267625292084691
ENST00000432124PPP2R4chr9131904831+ENST00000189978MUSKchr9113509921+2027160522016654
ENST00000432124PPP2R4chr9131904831+ENST00000374448MUSKchr9113509921+2027160522016654
ENST00000432124PPP2R4chr9131904831+ENST00000416899MUSKchr9113509921+2584160521992646
ENST00000419582PPP2R4chr9131904831+ENST00000189978MUSKchr9113509921+22483812732237654
ENST00000419582PPP2R4chr9131904831+ENST00000374448MUSKchr9113509921+22483812732237654
ENST00000419582PPP2R4chr9131904831+ENST00000416899MUSKchr9113509921+28053812732213646
ENST00000432651PPP2R4chr9131904831+ENST00000189978MUSKchr9113509921+2104237722093673
ENST00000432651PPP2R4chr9131904831+ENST00000374448MUSKchr9113509921+2104237722093673
ENST00000432651PPP2R4chr9131904831+ENST00000416899MUSKchr9113509921+2661237722069665
ENST00000435132PPP2R4chr9131904831+ENST00000189978MUSKchr9113509921+20992321062088660
ENST00000435132PPP2R4chr9131904831+ENST00000374448MUSKchr9113509921+20992321062088660
ENST00000435132PPP2R4chr9131904831+ENST00000416899MUSKchr9113509921+26562321062064652
ENST00000434095PPP2R4chr9131904831+ENST00000189978MUSKchr9113509921+21282611472117656
ENST00000434095PPP2R4chr9131904831+ENST00000374448MUSKchr9113509921+21282611472117656
ENST00000434095PPP2R4chr9131904831+ENST00000416899MUSKchr9113509921+26852611472093648

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358994ENST00000189978PPP2R4chr9131904831+MUSKchr9113509921+0.0017784640.9982216
ENST00000358994ENST00000374448PPP2R4chr9131904831+MUSKchr9113509921+0.0017772410.99822277
ENST00000358994ENST00000416899PPP2R4chr9131904831+MUSKchr9113509921+0.0008862860.99911374
ENST00000393370ENST00000189978PPP2R4chr9131904831+MUSKchr9113509921+0.0022149390.997785
ENST00000393370ENST00000374448PPP2R4chr9131904831+MUSKchr9113509921+0.0021970640.9978029
ENST00000393370ENST00000416899PPP2R4chr9131904831+MUSKchr9113509921+0.0011857650.9988142
ENST00000337738ENST00000189978PPP2R4chr9131904831+MUSKchr9113509921+0.0009545430.99904543
ENST00000337738ENST00000374448PPP2R4chr9131904831+MUSKchr9113509921+0.0009473230.9990527
ENST00000337738ENST00000416899PPP2R4chr9131904831+MUSKchr9113509921+0.0005694040.9994306
ENST00000348141ENST00000189978PPP2R4chr9131904831+MUSKchr9113509921+0.0017192060.99828076
ENST00000348141ENST00000374448PPP2R4chr9131904831+MUSKchr9113509921+0.0017073940.9982926
ENST00000348141ENST00000416899PPP2R4chr9131904831+MUSKchr9113509921+0.0008367220.99916327
ENST00000452489ENST00000189978PPP2R4chr9131904831+MUSKchr9113509921+0.0010259030.9989741
ENST00000452489ENST00000374448PPP2R4chr9131904831+MUSKchr9113509921+0.0010185740.9989814
ENST00000452489ENST00000416899PPP2R4chr9131904831+MUSKchr9113509921+0.0005900390.9994099
ENST00000357197ENST00000189978PPP2R4chr9131904831+MUSKchr9113509921+0.0025882210.9974118
ENST00000357197ENST00000374448PPP2R4chr9131904831+MUSKchr9113509921+0.0025603280.9974396
ENST00000357197ENST00000416899PPP2R4chr9131904831+MUSKchr9113509921+0.0011305360.9988695
ENST00000347048ENST00000189978PPP2R4chr9131904831+MUSKchr9113509921+0.0115382930.98846173
ENST00000347048ENST00000374448PPP2R4chr9131904831+MUSKchr9113509921+0.0115026660.9884974
ENST00000347048ENST00000416899PPP2R4chr9131904831+MUSKchr9113509921+0.0040829530.995917
ENST00000355007ENST00000189978PPP2R4chr9131904831+MUSKchr9113509921+0.0021672160.99783283
ENST00000355007ENST00000374448PPP2R4chr9131904831+MUSKchr9113509921+0.0021472440.9978528
ENST00000355007ENST00000416899PPP2R4chr9131904831+MUSKchr9113509921+0.00099090.999009
ENST00000423100ENST00000189978PPP2R4chr9131904831+MUSKchr9113509921+0.0140377320.9859622
ENST00000423100ENST00000374448PPP2R4chr9131904831+MUSKchr9113509921+0.0131585560.98684144
ENST00000423100ENST00000416899PPP2R4chr9131904831+MUSKchr9113509921+0.005498020.99450195
ENST00000524946ENST00000189978PPP2R4chr9131904831+MUSKchr9113509921+0.0085362430.9914637
ENST00000524946ENST00000374448PPP2R4chr9131904831+MUSKchr9113509921+0.0091172810.9908827
ENST00000524946ENST00000416899PPP2R4chr9131904831+MUSKchr9113509921+0.0034457290.99655426
ENST00000436883ENST00000189978PPP2R4chr9131904831+MUSKchr9113509921+0.0120535240.98794645
ENST00000436883ENST00000374448PPP2R4chr9131904831+MUSKchr9113509921+0.0109210080.98907894
ENST00000436883ENST00000416899PPP2R4chr9131904831+MUSKchr9113509921+0.0044332890.99556667
ENST00000414510ENST00000189978PPP2R4chr9131904831+MUSKchr9113509921+0.0120535240.98794645
ENST00000414510ENST00000374448PPP2R4chr9131904831+MUSKchr9113509921+0.0109210080.98907894
ENST00000414510ENST00000416899PPP2R4chr9131904831+MUSKchr9113509921+0.0044332890.99556667
ENST00000432124ENST00000189978PPP2R4chr9131904831+MUSKchr9113509921+0.0127425670.9872574
ENST00000432124ENST00000374448PPP2R4chr9131904831+MUSKchr9113509921+0.0115202630.9884798
ENST00000432124ENST00000416899PPP2R4chr9131904831+MUSKchr9113509921+0.0045820940.99541795
ENST00000419582ENST00000189978PPP2R4chr9131904831+MUSKchr9113509921+0.0139342840.98606575
ENST00000419582ENST00000374448PPP2R4chr9131904831+MUSKchr9113509921+0.0131223440.9868776
ENST00000419582ENST00000416899PPP2R4chr9131904831+MUSKchr9113509921+0.0054475560.99455243
ENST00000432651ENST00000189978PPP2R4chr9131904831+MUSKchr9113509921+0.0130824410.98691756
ENST00000432651ENST00000374448PPP2R4chr9131904831+MUSKchr9113509921+0.0121064860.9878935
ENST00000432651ENST00000416899PPP2R4chr9131904831+MUSKchr9113509921+0.0046351160.9953649
ENST00000435132ENST00000189978PPP2R4chr9131904831+MUSKchr9113509921+0.0136285050.98637146
ENST00000435132ENST00000374448PPP2R4chr9131904831+MUSKchr9113509921+0.0126531970.9873468
ENST00000435132ENST00000416899PPP2R4chr9131904831+MUSKchr9113509921+0.0047367090.99526334
ENST00000434095ENST00000189978PPP2R4chr9131904831+MUSKchr9113509921+0.0129135360.9870864
ENST00000434095ENST00000374448PPP2R4chr9131904831+MUSKchr9113509921+0.0119685450.9880314
ENST00000434095ENST00000416899PPP2R4chr9131904831+MUSKchr9113509921+0.0045292120.99547076

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for PPP2R4-MUSK

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
PPP2R4chr9131904831MUSKchr9113509921109620WAPSLDSWPAFSSVSSGSIQESVKDR
PPP2R4chr9131904831MUSKchr91135099211106366KVNQGLIRMYKAEVSSGSIQESVKDR
PPP2R4chr9131904831MUSKchr91135099211177336KVNQGLIRMYKAEVSSGSIQESVKDR
PPP2R4chr9131904831MUSKchr91135099211177342KVNQGLIRMYKAEVSSGSIQESVKDR
PPP2R4chr9131904831MUSKchr91135099211212371KVNQGLIRMYKAEVSSGSIQESVKDR
PPP2R4chr9131904831MUSKchr91135099211266371KVNQGLIRMYKAEVSSGSIQESVKDR
PPP2R4chr9131904831MUSKchr911350992116036KVNQGLIRMYKAEVSSGSIQESVKDR
PPP2R4chr9131904831MUSKchr911350992123242KVNQGLIRMYKAEVSSGSIQESVKDR
PPP2R4chr9131904831MUSKchr911350992123755KVNQGLIRMYKAEVSSGSIQESVKDR
PPP2R4chr9131904831MUSKchr911350992125281KVNQGLIRMYKAEVSSGSIQESVKDR
PPP2R4chr9131904831MUSKchr911350992126138KVNQGLIRMYKAEVSSGSIQESVKDR
PPP2R4chr9131904831MUSKchr911350992137637KVNQGLIRMYKAEVSSGSIQESVKDR
PPP2R4chr9131904831MUSKchr911350992138136KVNQGLIRMYKAEVSSGSIQESVKDR
PPP2R4chr9131904831MUSKchr9113509921429117KVNQGLIRMYKAEVSSGSIQESVKDR
PPP2R4chr9131904831MUSKchr9113509921955294KVNQGLIRMYKAEVSSGSIQESVKDR
PPP2R4chr9131904831MUSKchr9113509921999307KVNQGLIRMYKAEVSSGSIQESVKDR

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Potential FusionNeoAntigen Information of PPP2R4-MUSK in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
PPP2R4-MUSK_131904831_113509921.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
PPP2R4-MUSKchr9131904831chr91135099211096HLA-B52:01DSWPAFSSV0.99880.8919514
PPP2R4-MUSKchr9131904831chr91135099211096HLA-A02:27SLDSWPAFSSV0.99320.5176314
PPP2R4-MUSKchr9131904831chr91135099211096HLA-A02:13SLDSWPAFSSV0.99270.6051314
PPP2R4-MUSKchr9131904831chr91135099211096HLA-A02:38SLDSWPAFSSV0.98690.6333314
PPP2R4-MUSKchr9131904831chr91135099211096HLA-A02:19SLDSWPAFSSV0.97080.5062314
PPP2R4-MUSKchr9131904831chr91135099211096HLA-B51:07DSWPAFSSV0.99940.7162514
PPP2R4-MUSKchr9131904831chr91135099211096HLA-B78:01DSWPAFSSV0.99930.5352514
PPP2R4-MUSKchr9131904831chr91135099211096HLA-B78:02DSWPAFSSV0.99950.5784514
PPP2R4-MUSKchr9131904831chr91135099211266HLA-A69:01EVSSGSIQESV0.99590.59791223

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Potential FusionNeoAntigen Information of PPP2R4-MUSK in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
PPP2R4-MUSK_131904831_113509921.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0401IRMYKAEVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0401LIRMYKAEVSSGSIQ520
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0401RMYKAEVSSGSIQES722
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0407IRMYKAEVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0419IRMYKAEVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0419LIRMYKAEVSSGSIQ520
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0431IRMYKAEVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0431LIRMYKAEVSSGSIQ520
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0433IRMYKAEVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0433LIRMYKAEVSSGSIQ520
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0433RMYKAEVSSGSIQES722
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0434IRMYKAEVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0434LIRMYKAEVSSGSIQ520
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0435IRMYKAEVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0435LIRMYKAEVSSGSIQ520
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0437QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0437NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0438IRMYKAEVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0438LIRMYKAEVSSGSIQ520
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0443IRMYKAEVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0447IRMYKAEVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0454IRMYKAEVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0458QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0461IRMYKAEVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0461LIRMYKAEVSSGSIQ520
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0463IRMYKAEVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0463LIRMYKAEVSSGSIQ520
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0463RMYKAEVSSGSIQES722
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0464IRMYKAEVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0464LIRMYKAEVSSGSIQ520
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0465QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0465NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0472IRMYKAEVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0472LIRMYKAEVSSGSIQ520
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0472RMYKAEVSSGSIQES722
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0473QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0473NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0474IRMYKAEVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0474LIRMYKAEVSSGSIQ520
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0475IRMYKAEVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0476IRMYKAEVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0476LIRMYKAEVSSGSIQ520
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0476RMYKAEVSSGSIQES722
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0701WPAFSSVSSGSIQES722
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0701SWPAFSSVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0701PAFSSVSSGSIQESV823
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0703WPAFSSVSSGSIQES722
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0703SWPAFSSVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0703PAFSSVSSGSIQESV823
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0705WPAFSSVSSGSIQES722
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0705SWPAFSSVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0705PAFSSVSSGSIQESV823
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0706WPAFSSVSSGSIQES722
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0706SWPAFSSVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0707WPAFSSVSSGSIQES722
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0707SWPAFSSVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0707PAFSSVSSGSIQESV823
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0708WPAFSSVSSGSIQES722
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0708SWPAFSSVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0708PAFSSVSSGSIQESV823
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0709WPAFSSVSSGSIQES722
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0709SWPAFSSVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0709PAFSSVSSGSIQESV823
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0711WPAFSSVSSGSIQES722
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0711SWPAFSSVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0712WPAFSSVSSGSIQES722
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0712SWPAFSSVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0712PAFSSVSSGSIQESV823
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0713WPAFSSVSSGSIQES722
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0713SWPAFSSVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0713PAFSSVSSGSIQESV823
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0714WPAFSSVSSGSIQES722
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0714SWPAFSSVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0714PAFSSVSSGSIQESV823
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0715WPAFSSVSSGSIQES722
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0715SWPAFSSVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0715PAFSSVSSGSIQESV823
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0716WPAFSSVSSGSIQES722
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0716SWPAFSSVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0716PAFSSVSSGSIQESV823
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0717WPAFSSVSSGSIQES722
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0717SWPAFSSVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0717PAFSSVSSGSIQESV823
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0719WPAFSSVSSGSIQES722
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0719SWPAFSSVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0719PAFSSVSSGSIQESV823
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0804NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0806NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0810NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0810QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0812NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0812QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0820NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0822NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0828NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0828VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-0831NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211096DRB1-0907WPAFSSVSSGSIQES722
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1001IRMYKAEVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1003IRMYKAEVSSGSIQE621
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1104NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1106NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1113NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1113VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1117NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1117VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1118NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1118VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1125NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1127NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1134NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1134VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1135NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1138NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1142NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1142VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1143NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1144NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1145NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1146NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1147NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1150NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1152NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1152VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1154NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1156NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1157NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1157VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1158NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1160NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1167NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1167VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1169NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1172NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1172VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1177NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1178NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1183NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1184NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1184VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1188NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1189NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1189VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1192NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1192VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1192QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1204NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1204QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1204VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1209NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1209QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1209VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1219NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1220NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1304NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1306NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1306VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1309NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1309QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-13100NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1311NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1317NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1318NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1326NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1342NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1343NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1344NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1344VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1346NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1354NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1358NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1377NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1377VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1386NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1393NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1402NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1403NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1404NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1405NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1405VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1406NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1406VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1406QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1408NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1408VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1411NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1411VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1412NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1412VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1412QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1415NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1416NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1417NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1417VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1418NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1418VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1420NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1420VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1420QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1421NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1423NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1423VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1424NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1427NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1428NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1429NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1429VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1429QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1430NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1431NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1431VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1432NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1432VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1433NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1434NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1434VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1437NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1437QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1439NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1440NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1441NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1443NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1445NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1449NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1452NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1452QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1452VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1455NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1456NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1456VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1457QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1457NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1459NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1459VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1461NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1462NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1464NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1465NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1465VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1467NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1470NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1471NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1472NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1473NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1474NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1474VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1477NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1478NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1478VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1478QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1480NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1480VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1481NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1481VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1481QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1483NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1483VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1483QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1484NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1489NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1491NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1491VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1494NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1496NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1496VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1501QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1501NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1501GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1501VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1502QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1502NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1502GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1502VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1503QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1503NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1503VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1503GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1504QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1504NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1504GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1504VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1505QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1505NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1505GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1505VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1506QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1506NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1506GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1506VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1507QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1507NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1507VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1507GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1508QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1508NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1508GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1508VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1509QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1509NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1509GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1509VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1510QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1510NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1510GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1510VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1511QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1511NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1511GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1512QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1512NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1512VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1512GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1513QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1513NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1513GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1513VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1514QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1514NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1514GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1514VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1515QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1515NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1515GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1516QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1516NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1516GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1516VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1518QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1518NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1518GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1518VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1519QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1519NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1519GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1519VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1520QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1520NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1520GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1520VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1521QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1521NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1521VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1521GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1522QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1522NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1522GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1522VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1523QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1523NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1523VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1523GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1524QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1524NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1524GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1524VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1525QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1526QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1526NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1526GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1526VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1527QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1528QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1528NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1528GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1528VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1529QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1529NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1530QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1530NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1530VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1530GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1531QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1531NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1531GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1532QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1532NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1532GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1532VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1533QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1533NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1533GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1533VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1535QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1535NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1535GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1535VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1536QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1536NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1536GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1536VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1537QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1537NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1537GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1537VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1538QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1538NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1538GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1538VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1539QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1539NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1539GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1539VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1540QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1540NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1540GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1540VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1541QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1541NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1541GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1541VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1542QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1542NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1542GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1542VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1543QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1543NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1543GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1543VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1544QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1544NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1544GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1544VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1545QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1545NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1545GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1545VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1546QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1546NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1546GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1546VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1547QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1547NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1547GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1547VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1548QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1548NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1548VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1548GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1549QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1549NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1549GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1549VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1604QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1610QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1615QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB1-1615NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB5-0103QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB5-0103NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB5-0106QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB5-0106NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB5-0202QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB5-0202NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB5-0202VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB5-0202GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB5-0203QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB5-0203NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB5-0204QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB5-0204NQGLIRMYKAEVSSG217
PPP2R4-MUSKchr9131904831chr91135099211266DRB5-0204GLIRMYKAEVSSGSI419
PPP2R4-MUSKchr9131904831chr91135099211266DRB5-0204VNQGLIRMYKAEVSS116
PPP2R4-MUSKchr9131904831chr91135099211266DRB5-0205QGLIRMYKAEVSSGS318
PPP2R4-MUSKchr9131904831chr91135099211266DRB5-0205NQGLIRMYKAEVSSG217

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Fusion breakpoint peptide structures of PPP2R4-MUSK

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
3951IRMYKAEVSSGSIQPPP2R4MUSKchr9131904831chr91135099211266
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
9186SWPAFSSVSSGSIQPPP2R4MUSKchr9131904831chr91135099211096

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of PPP2R4-MUSK

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN3951IRMYKAEVSSGSIQ-7.30246-7.41586
HLA-B14:023BVN3951IRMYKAEVSSGSIQ-5.55986-6.59516
HLA-B52:013W393951IRMYKAEVSSGSIQ-5.35289-5.46629
HLA-B52:013W393951IRMYKAEVSSGSIQ-3.71104-4.74634
HLA-A24:025HGA3951IRMYKAEVSSGSIQ-10.6558-10.7692
HLA-A24:025HGA3951IRMYKAEVSSGSIQ-5.03335-6.06865
HLA-B44:053DX83951IRMYKAEVSSGSIQ-9.59104-9.70444
HLA-B44:053DX83951IRMYKAEVSSGSIQ-4.54423-5.57953
HLA-B14:023BVN9186SWPAFSSVSSGSIQ-7.15543-7.26883
HLA-B14:023BVN9186SWPAFSSVSSGSIQ-4.77435-5.80965
HLA-B52:013W399186SWPAFSSVSSGSIQ-6.80875-6.92215
HLA-B52:013W399186SWPAFSSVSSGSIQ-4.20386-5.23916
HLA-A11:014UQ29186SWPAFSSVSSGSIQ-7.5194-8.5547
HLA-A11:014UQ29186SWPAFSSVSSGSIQ-6.9601-7.0735
HLA-A24:025HGA9186SWPAFSSVSSGSIQ-7.52403-7.63743
HLA-A24:025HGA9186SWPAFSSVSSGSIQ-5.82433-6.85963
HLA-B27:056PYJ9186SWPAFSSVSSGSIQ-3.28285-4.31815
HLA-B44:053DX89186SWPAFSSVSSGSIQ-5.91172-6.94702
HLA-B44:053DX89186SWPAFSSVSSGSIQ-4.24346-4.35686

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Vaccine Design for the FusionNeoAntigens of PPP2R4-MUSK

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
PPP2R4-MUSKchr9131904831chr91135099211223EVSSGSIQESVGAGGTTTCTTCTGGGTCCATTCAAGAGAGTGTG
PPP2R4-MUSKchr9131904831chr9113509921314SLDSWPAFSSVTCTCTTGACTCCTGGCCGGCCTTCTCTTCTGTT
PPP2R4-MUSKchr9131904831chr9113509921514DSWPAFSSVGACTCCTGGCCGGCCTTCTCTTCTGTT

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
PPP2R4-MUSKchr9131904831chr9113509921116VNQGLIRMYKAEVSSGTGAACCAGGGTCTCATCCGCATGTATAAGGCCGAGGTTTCTTCT
PPP2R4-MUSKchr9131904831chr9113509921217NQGLIRMYKAEVSSGAACCAGGGTCTCATCCGCATGTATAAGGCCGAGGTTTCTTCTGGG
PPP2R4-MUSKchr9131904831chr9113509921318QGLIRMYKAEVSSGSCAGGGTCTCATCCGCATGTATAAGGCCGAGGTTTCTTCTGGGTCC
PPP2R4-MUSKchr9131904831chr9113509921419GLIRMYKAEVSSGSIGGTCTCATCCGCATGTATAAGGCCGAGGTTTCTTCTGGGTCCATT
PPP2R4-MUSKchr9131904831chr9113509921520LIRMYKAEVSSGSIQCTCATCCGCATGTATAAGGCCGAGGTTTCTTCTGGGTCCATTCAA
PPP2R4-MUSKchr9131904831chr9113509921621IRMYKAEVSSGSIQEATCCGCATGTATAAGGCCGAGGTTTCTTCTGGGTCCATTCAAGAG
PPP2R4-MUSKchr9131904831chr9113509921621SWPAFSSVSSGSIQETCCTGGCCGGCCTTCTCTTCTGTTTCTTCTGGGTCCATTCAAGAG
PPP2R4-MUSKchr9131904831chr9113509921722RMYKAEVSSGSIQESCGCATGTATAAGGCCGAGGTTTCTTCTGGGTCCATTCAAGAGAGT
PPP2R4-MUSKchr9131904831chr9113509921722WPAFSSVSSGSIQESTGGCCGGCCTTCTCTTCTGTTTCTTCTGGGTCCATTCAAGAGAGT
PPP2R4-MUSKchr9131904831chr9113509921823PAFSSVSSGSIQESVCCGGCCTTCTCTTCTGTTTCTTCTGGGTCCATTCAAGAGAGTGTG

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Information of the samples that have these potential fusion neoantigens of PPP2R4-MUSK

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
SARCPPP2R4-MUSKchr9131904831ENST00000337738chr9113509921ENST00000189978TCGA-DX-A48K-01A
SARCPPP2R4-MUSKchr9131904831ENST00000524946chr9113509921ENST00000189978TCGA-DX-A48K-01A

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Potential target of CAR-T therapy development for PPP2R4-MUSK

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMUSKchr9:131904831chr9:113509921ENST00000374448515496_5160870.0TransmembraneHelical

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to PPP2R4-MUSK

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PPP2R4-MUSK

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource