FusionNeoAntigen Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use

Center for Computational Systems Medicine
leaf

Fusion Gene and Fusion Protein Summary

leaf

Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

leaf

Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

leaf

Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

leaf

Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

leaf

Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

leaf

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

leaf

Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

leaf

Potential target of CAR-T therapy development

leaf

Information on the samples that have these potential fusion neoantigens

leaf

Fusion Protein Targeting Drugs - (Manual Curation)

leaf

Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:ARSG-STAT5B

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ARSG-STAT5B
FusionPDB ID: 6904
FusionGDB2.0 ID: 6904
HgeneTgene
Gene symbol

ARSG

STAT5B

Gene ID

22901

6777

Gene namearylsulfatase Gsignal transducer and activator of transcription 5B
SynonymsUSH4STAT5
Cytomap

17q24.2

17q21.2

Type of geneprotein-codingprotein-coding
Descriptionarylsulfatase GASGsignal transducer and activator of transcription 5Btranscription factor STAT5B
Modification date2020031320200313
UniProtAcc

Q96EG1

Main function of 5'-partner protein: FUNCTION: Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. {ECO:0000269|PubMed:18283100, ECO:0000269|PubMed:29300381}.
.
Ensembl transtripts involved in fusion geneENST idsENST00000582154, ENST00000448504, 
ENST00000452479, 
ENST00000293328, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 13 X 7=163810 X 6 X 7=420
# samples 1810
** MAII scorelog2(18/1638*10)=-3.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/420*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: ARSG [Title/Abstract] AND STAT5B [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: ARSG [Title/Abstract] AND STAT5B [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ARSG(66397591)-STAT5B(40354826), # samples:1
Anticipated loss of major functional domain due to fusion event.ARSG-STAT5B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARSG-STAT5B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARSG

GO:0006790

sulfur compound metabolic process

18283100

TgeneSTAT5B

GO:0032355

response to estradiol

12552091

TgeneSTAT5B

GO:0032870

cellular response to hormone stimulus

12552091

TgeneSTAT5B

GO:0045648

positive regulation of erythrocyte differentiation

20702587

TgeneSTAT5B

GO:0060397

JAK-STAT cascade involved in growth hormone signaling pathway

12552091



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:66397591/chr17:40354826)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across ARSG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across STAT5B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000448504ARSGchr1766397591+ENST00000293328STAT5Bchr1740354826-495620997962385529
ENST00000452479ARSGchr1766397591+ENST00000293328STAT5Bchr1740354826-399311361031422439

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000448504ENST00000293328ARSGchr1766397591+STAT5Bchr1740354826-0.0006144920.9993855
ENST00000452479ENST00000293328ARSGchr1766397591+STAT5Bchr1740354826-0.0027572920.9972427

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

Top

Fusion Protein Breakpoint Sequences for ARSG-STAT5B

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
ARSGchr1766397591STAT5Bchr17403548261136344TVRLERYKAFYITAKAVDGYVKPQIK
ARSGchr1766397591STAT5Bchr17403548262099434TVRLERYKAFYITAKAVDGYVKPQIK

Top

Potential FusionNeoAntigen Information of ARSG-STAT5B in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
ARSG-STAT5B_66397591_40354826.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
ARSG-STAT5Bchr1766397591chr17403548262099HLA-A30:08KAFYITAKA0.98320.5781716
ARSG-STAT5Bchr1766397591chr17403548262099HLA-B15:17ITAKAVDGY0.97330.5841120
ARSG-STAT5Bchr1766397591chr17403548262099HLA-B39:06ERYKAFYITA0.98770.5507414
ARSG-STAT5Bchr1766397591chr17403548262099HLA-C14:02FYITAKAV0.64860.9697917
ARSG-STAT5Bchr1766397591chr17403548262099HLA-C14:03FYITAKAV0.64860.9697917
ARSG-STAT5Bchr1766397591chr17403548262099HLA-A30:01RYKAFYITA0.9520.7941514
ARSG-STAT5Bchr1766397591chr17403548262099HLA-A30:01RYKAFYITAK0.9920.7986515

Top

Potential FusionNeoAntigen Information of ARSG-STAT5B in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
ARSG-STAT5B_66397591_40354826.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0101KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0103KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0105KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0107KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0109KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0111KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0113KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0113YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0115KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0117KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0117YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0119KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0121KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0121YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0125KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0127KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0129KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0131KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0447KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0454KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0474KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0801RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0801YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0801ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0801KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0802YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0803YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0803RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0803ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0803KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0805RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0805YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0805ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0805KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0807YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0807RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0807KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0807ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0808RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0808YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0808ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0808KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0809YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0811RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0811YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0811ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0811KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0813YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0813KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0813RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0814YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0814RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0814ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0814KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0815YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0815KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0815RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0816RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0816YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0816ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0816KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0818RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0818YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0818ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0818KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0819YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0819RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0821YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0823YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0823RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0823ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0823KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0824YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0825YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0825RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0826RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0826YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0826ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0826KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0827YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0827RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0827ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0827KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0829RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0829YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0829ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0829KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0829LERYKAFYITAKAVD318
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0830YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0830KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0830RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0832YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0832RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0832KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0832ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0833YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0833RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0833ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0833KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0834YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0834RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0835YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0835RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0835ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0835KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0836YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0836RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0836ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0836KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0837YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0837RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0837ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0837KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0838YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0838RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0838ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0838KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0839RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0839YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0839ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0839KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0840RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0840YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0840ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0840KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0902KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0902YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0902RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0903KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0908KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0908YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-0908RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1001KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1001YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1003KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1003YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1105YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1108YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1108RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1119YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1119RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1127YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1130KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1130YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1131YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1131RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1137YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1137RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1145YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1153RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1153YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1153ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1164YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1164RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1173YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1173RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1180YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1187YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1303RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1303YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1303ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1303KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1307YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1307RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-13100RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-13100YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-13100ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-13100KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-13101RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-13101ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-13101YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-13101KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1310RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1310ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1310YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1310KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1312RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1312YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1312ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1312KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1313RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1313YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1313ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1313KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1321RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1321YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1321ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1321KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1330RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1330YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1330ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1330KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1333RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1333YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1333ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1333KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1337YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1337RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1338RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1338YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1338ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1338KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1346RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1346YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1346ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1346KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1347YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1347RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1349RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1349YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1349ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1349KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1355RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1355YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1355ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1355KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1356YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1356RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1360YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1360RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1365RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1365YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1365ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1365KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1366RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1366YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1366ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1366KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1382YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1382RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1388RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1388ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1388YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1388KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1390RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1390YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1390ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1390KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1395RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1395YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1395ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1395KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1403YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1407YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1407RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1407ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1407KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1409YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1413YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1413RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1413ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1413KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1414YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1414RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1414ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1414KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1422RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1422YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1422ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1422KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1425RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1425YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1425ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1425KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1430YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1436YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1436RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1436ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1436KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1440YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1442YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1442RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1442ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1442KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1444YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1444RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1444ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1444KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1446KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1449YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1449RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1451YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1451RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1451KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1451ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1453RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1453YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1453ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1453KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1463YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1463RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1463ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1463KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1467YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1467KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1468RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1468YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1468ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1468KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1469YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1469RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1469ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1469KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1473RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1473YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1477YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1485RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1485YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1485ERYKAFYITAKAVDG419
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1485KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1493YKAFYITAKAVDGYV621
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1493RYKAFYITAKAVDGY520
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1501TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1501VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1502TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1502VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1503TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1503VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1504TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1504VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1505TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1505VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1506TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1506VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1507TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1507VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1508TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1508VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1509TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1509VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1510TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1510VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1511TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1512TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1512VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1513TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1513VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1514TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1514VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1515TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1516TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1516VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1518TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1518VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1519TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1519VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1520TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1520VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1521TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1521VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1522TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1522VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1523TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1524TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1524VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1525TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1526TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1526VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1527TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1528TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1528VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1529TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1529VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1530TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1530VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1531TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1531VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1532TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1532VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1533TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1533VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1535TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1535VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1536TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1536VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1537TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1537VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1538TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1538VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1539TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1539VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1540TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1540VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1541TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1541VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1542TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1542VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1543TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1543VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1544TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1544VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1545TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1545VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1546TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1546VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1547TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1547VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1548TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1548VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1549TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1549VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1601KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1603KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1604KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1608KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1610TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB1-1615TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB3-0217KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB5-0106TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB5-0112KAFYITAKAVDGYVK722
ARSG-STAT5Bchr1766397591chr17403548262099DRB5-0202TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB5-0202VRLERYKAFYITAKA116
ARSG-STAT5Bchr1766397591chr17403548262099DRB5-0203TVRLERYKAFYITAK015
ARSG-STAT5Bchr1766397591chr17403548262099DRB5-0204TVRLERYKAFYITAK015

Top

Fusion breakpoint peptide structures of ARSG-STAT5B

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
10686YKAFYITAKAVDGYARSGSTAT5Bchr1766397591chr17403548262099

Top

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ARSG-STAT5B

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN10686YKAFYITAKAVDGY-7.15543-7.26883
HLA-B14:023BVN10686YKAFYITAKAVDGY-4.77435-5.80965
HLA-B52:013W3910686YKAFYITAKAVDGY-6.80875-6.92215
HLA-B52:013W3910686YKAFYITAKAVDGY-4.20386-5.23916
HLA-A11:014UQ210686YKAFYITAKAVDGY-7.5194-8.5547
HLA-A11:014UQ210686YKAFYITAKAVDGY-6.9601-7.0735
HLA-A24:025HGA10686YKAFYITAKAVDGY-7.52403-7.63743
HLA-A24:025HGA10686YKAFYITAKAVDGY-5.82433-6.85963
HLA-B27:056PYJ10686YKAFYITAKAVDGY-3.28285-4.31815
HLA-B44:053DX810686YKAFYITAKAVDGY-5.91172-6.94702
HLA-B44:053DX810686YKAFYITAKAVDGY-4.24346-4.35686

Top

Vaccine Design for the FusionNeoAntigens of ARSG-STAT5B

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
ARSG-STAT5Bchr1766397591chr17403548261120ITAKAVDGYTTACCGCTAAAGCTGTTGATGGATACG
ARSG-STAT5Bchr1766397591chr1740354826414ERYKAFYITAAGCGTTACAAGGCCTTCTACATTACCGCTA
ARSG-STAT5Bchr1766397591chr1740354826514RYKAFYITAGTTACAAGGCCTTCTACATTACCGCTA
ARSG-STAT5Bchr1766397591chr1740354826515RYKAFYITAKGTTACAAGGCCTTCTACATTACCGCTAAAG
ARSG-STAT5Bchr1766397591chr1740354826716KAFYITAKAAGGCCTTCTACATTACCGCTAAAGCTG
ARSG-STAT5Bchr1766397591chr1740354826917FYITAKAVTCTACATTACCGCTAAAGCTGTTG

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
ARSG-STAT5Bchr1766397591chr1740354826015TVRLERYKAFYITAKCTGTCCGCCTGGAGCGTTACAAGGCCTTCTACATTACCGCTAAAG
ARSG-STAT5Bchr1766397591chr1740354826116VRLERYKAFYITAKATCCGCCTGGAGCGTTACAAGGCCTTCTACATTACCGCTAAAGCTG
ARSG-STAT5Bchr1766397591chr1740354826318LERYKAFYITAKAVDTGGAGCGTTACAAGGCCTTCTACATTACCGCTAAAGCTGTTGATG
ARSG-STAT5Bchr1766397591chr1740354826419ERYKAFYITAKAVDGAGCGTTACAAGGCCTTCTACATTACCGCTAAAGCTGTTGATGGAT
ARSG-STAT5Bchr1766397591chr1740354826520RYKAFYITAKAVDGYGTTACAAGGCCTTCTACATTACCGCTAAAGCTGTTGATGGATACG
ARSG-STAT5Bchr1766397591chr1740354826621YKAFYITAKAVDGYVACAAGGCCTTCTACATTACCGCTAAAGCTGTTGATGGATACGTGA
ARSG-STAT5Bchr1766397591chr1740354826722KAFYITAKAVDGYVKAGGCCTTCTACATTACCGCTAAAGCTGTTGATGGATACGTGAAGC

Top

Information of the samples that have these potential fusion neoantigens of ARSG-STAT5B

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
BRCAARSG-STAT5Bchr1766397591ENST00000448504chr1740354826ENST00000293328TCGA-AR-A24U-01A

Top

Potential target of CAR-T therapy development for ARSG-STAT5B

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

Top

Related Drugs to ARSG-STAT5B

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to ARSG-STAT5B

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource