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Fusion Protein:RGS20-MCPH1

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: RGS20-MCPH1
	FusionPDB ID: 73815
	FusionGDB2.0 ID: 73815
		Hgene	Tgene
	Gene symbol	RGS20	MCPH1
	Gene ID	8601	79648
	Gene name	regulator of G protein signaling 20	microcephalin 1
	Synonyms	RGSZ1\|ZGAP1\|g(z)GAP\|gz-GAP	BRIT1\|MCT
	Cytomap	8q11.23	8p23.1
	Type of gene	protein-coding	protein-coding
	Description	regulator of G-protein signaling 20gz-selective GTPase-activating proteinregulator of G-protein signaling 20 variant 2regulator of G-protein signaling Z1regulator of G-protein signalling 20regulator of Gz-selective protein signaling 1	microcephalinBRCT-repeat inhibitor of TERT expression 1truncated microcephalin
	Modification date	20200327	20200328
	UniProtAcc	.	Q8NEM0 Main function of 5'-partner protein: FUNCTION: Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. {ECO:0000269\|PubMed:12046007, ECO:0000269\|PubMed:15199523, ECO:0000269\|PubMed:15220350}.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000276500, ENST00000297313, ENST00000522225, ENST00000344277, ENST00000517405,	ENST00000519480, ENST00000521175, ENST00000522905, ENST00000344683,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 5 X 2=40	8 X 11 X 4=352
	# samples	4	9
	** MAII score	log2(4/40*10)=0	log2(9/352*10)=-1.96757852230762 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: RGS20 [Title/Abstract] AND MCPH1 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: RGS20 [Title/Abstract] AND MCPH1 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	RGS20(54793644)-MCPH1(6335115), # samples:3
Anticipated loss of major functional domain due to fusion event.	RGS20-MCPH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RGS20-MCPH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RGS20-MCPH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RGS20-MCPH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RGS20-MCPH1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. RGS20-MCPH1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. RGS20-MCPH1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MCPH1	GO:0000122	negative regulation of transcription by RNA polymerase II	12837246
Tgene	MCPH1	GO:0071850	mitotic cell cycle arrest	24633962

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:54793644/chr8:6335115)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across RGS20 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MCPH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000276500

RGS20

chr8

54793644

ENST00000344683

MCPH1

chr8

6335115

1338

191

122

763

213

ENST00000297313

RGS20

chr8

54792162

ENST00000344683

MCPH1

chr8

6335115

1749

602

1174

360

ENST00000276500

RGS20

chr8

54793644

ENST00000344683

MCPH1

chr8

6357373

1137

191

122

562

146

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000276500	ENST00000344683	RGS20	chr8	54793644	+	MCPH1	chr8	6335115	+	0.1827721	0.8172279
ENST00000297313	ENST00000344683	RGS20	chr8	54792162	+	MCPH1	chr8	6335115	+	0.24326591	0.75673413
ENST00000276500	ENST00000344683	RGS20	chr8	54793644	+	MCPH1	chr8	6357373	+	0.5010669	0.49893305

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for RGS20-MCPH1

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
RGS20	chr8	54792162	MCPH1	chr8	6335115	602	170	EEDATAGQSSPMPPTRTLVMTSMPSE
RGS20	chr8	54793644	MCPH1	chr8	6335115	191	23	GASSPAGRVDGGLPTRTLVMTSMPSE
RGS20	chr8	54793644	MCPH1	chr8	6357373	191	23	GASSPAGRVDGGLVLWSLELGHWISE

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Potential FusionNeoAntigen Information of RGS20-MCPH1 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

RGS20-MCPH1_54792162_6335115.msa
RGS20-MCPH1_54793644_6335115.msa
RGS20-MCPH1_54793644_6357373.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B08:09	MPPTRTLV	0.9968	0.7032	11	19
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B07:10	SPMPPTRTL	0.9998	0.5147	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B08:01	MPPTRTLVM	0.9951	0.5551	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:01	MPPTRTLVM	0.9919	0.9511	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B08:09	MPPTRTLVM	0.9908	0.7144	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:08	MPPTRTLVM	0.9891	0.9297	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:03	SPMPPTRTL	0.984	0.8835	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:03	MPPTRTLVM	0.9832	0.9293	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-A68:08	QSSPMPPTR	0.9805	0.5088	7	16
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:05	MPPTRTLVM	0.9781	0.6966	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:01	SPMPPTRTL	0.9712	0.8761	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B14:02	SPMPPTRTL	0.966	0.7307	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-A31:06	QSSPMPPTR	0.966	0.6461	7	16
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B14:01	SPMPPTRTL	0.966	0.7307	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B14:01	MPPTRTLVM	0.9651	0.8538	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B14:02	MPPTRTLVM	0.9651	0.8538	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:08	SPMPPTRTL	0.9495	0.8398	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-A31:02	QSSPMPPTR	0.9477	0.8524	7	16
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-A74:11	QSSPMPPTR	0.9467	0.8061	7	16
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-A74:09	QSSPMPPTR	0.9467	0.8061	7	16
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-A74:03	QSSPMPPTR	0.9467	0.8061	7	16
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-A34:05	QSSPMPPTR	0.9444	0.5492	7	16
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-A34:01	QSSPMPPTR	0.9444	0.5492	7	16
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B15:18	SPMPPTRTL	0.9406	0.6768	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B08:01	SPMPPTRTL	0.9352	0.5203	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B15:10	SPMPPTRTL	0.9348	0.5729	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:02	SPMPPTRTL	0.929	0.9141	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:04	SPMPPTRTL	0.929	0.9141	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B39:01	SPMPPTRTL	0.9273	0.9172	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:05	SPMPPTRTL	0.9159	0.5156	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B39:06	SPMPPTRTL	0.9132	0.7486	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B15:37	SPMPPTRTL	0.9058	0.558	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B08:09	SPMPPTRTL	0.8582	0.6017	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B15:02	SPMPPTRTL	0.8515	0.882	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:04	MPPTRTLVM	0.8386	0.9724	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:02	MPPTRTLVM	0.8386	0.9724	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B52:01	SPMPPTRTL	0.8016	0.6221	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-A66:03	QSSPMPPTR	0.8016	0.6137	7	16
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B39:13	SPMPPTRTL	0.7209	0.9264	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B38:02	SPMPPTRTL	0.6666	0.9681	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B38:01	SPMPPTRTL	0.5992	0.959	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B08:09	SPMPPTRTLV	0.9501	0.5985	9	19
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B15:17	SSPMPPTRTL	0.9458	0.8515	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B57:03	SSPMPPTRTL	0.9397	0.9363	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B58:02	SSPMPPTRTL	0.9371	0.9284	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B15:16	SSPMPPTRTL	0.9364	0.5145	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:03	SSPMPPTRTL	0.9116	0.9182	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-A31:06	GQSSPMPPTR	0.8814	0.7766	6	16
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:05	SSPMPPTRTL	0.8757	0.5686	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:03	SPMPPTRTLV	0.8508	0.6672	9	19
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:02	SSPMPPTRTL	0.8029	0.9372	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:04	SSPMPPTRTL	0.8029	0.9372	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-A30:08	SSPMPPTRTL	0.7115	0.7468	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B07:10	SPMPPTRTLVM	1	0.5382	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:01	SPMPPTRTLVM	0.9981	0.8074	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B08:01	SPMPPTRTLVM	0.9979	0.6352	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:03	SPMPPTRTLVM	0.9972	0.802	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B07:02	QSSPMPPTRTL	0.9969	0.6158	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B07:10	QSSPMPPTRTL	0.9967	0.667	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B07:05	QSSPMPPTRTL	0.9965	0.5131	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:08	SPMPPTRTLVM	0.9961	0.7522	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B08:09	SPMPPTRTLVM	0.9956	0.7386	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:05	SPMPPTRTLVM	0.9951	0.5128	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B57:03	QSSPMPPTRTL	0.9932	0.9859	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B81:01	QSSPMPPTRTL	0.9914	0.7023	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:02	SPMPPTRTLVM	0.9876	0.9143	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:04	SPMPPTRTLVM	0.9876	0.9143	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:03	QSSPMPPTRTL	0.9811	0.9579	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:04	QSSPMPPTRTL	0.964	0.9798	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:02	QSSPMPPTRTL	0.964	0.9798	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B82:01	QSSPMPPTRTL	0.9151	0.5777	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C01:17	PMPPTRTL	0.9847	0.9704	10	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C01:30	PMPPTRTL	0.9764	0.9714	10	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B42:01	PMPPTRTL	0.9662	0.6185	10	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B42:02	PMPPTRTL	0.9649	0.6254	10	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B07:12	PMPPTRTL	0.9258	0.6948	10	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B39:10	PMPPTRTL	0.8708	0.9601	10	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B07:12	SPMPPTRTL	0.9992	0.5709	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B42:02	MPPTRTLVM	0.9966	0.5869	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B42:01	MPPTRTLVM	0.9963	0.5773	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:19	SPMPPTRTL	0.9696	0.9592	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B42:01	SPMPPTRTL	0.966	0.5056	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B42:02	SPMPPTRTL	0.9653	0.5043	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B15:31	SPMPPTRTL	0.958	0.8436	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:08	SPMPPTRTL	0.9557	0.8688	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B39:09	SPMPPTRTL	0.9552	0.7203	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:07	SPMPPTRTL	0.9533	0.9103	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-A31:01	QSSPMPPTR	0.9501	0.8136	7	16
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B39:10	SPMPPTRTL	0.9468	0.9247	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B14:03	MPPTRTLVM	0.9447	0.887	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:12	SPMPPTRTL	0.929	0.9141	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B39:12	SPMPPTRTL	0.9275	0.9238	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B39:09	MPPTRTLVM	0.9057	0.8374	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B07:12	MPPTRTLVM	0.8908	0.6358	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B15:21	SPMPPTRTL	0.8799	0.9072	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B39:10	MPPTRTLVM	0.8576	0.9645	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B14:03	SPMPPTRTL	0.8539	0.7983	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:12	MPPTRTLVM	0.8386	0.9724	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B51:07	SPMPPTRTL	0.8334	0.5759	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C08:03	SPMPPTRTL	0.8185	0.9657	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B39:08	SPMPPTRTL	0.7813	0.8648	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B78:01	MPPTRTLVM	0.7717	0.5301	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C15:06	SPMPPTRTL	0.7514	0.8276	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C07:13	MPPTRTLVM	0.7417	0.9706	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B39:05	SPMPPTRTL	0.7006	0.9077	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C07:13	SPMPPTRTL	0.6821	0.8896	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C08:04	SPMPPTRTL	0.679	0.9042	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C08:13	SPMPPTRTL	0.679	0.9042	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C07:29	MPPTRTLVM	0.6765	0.9774	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C07:05	SPMPPTRTL	0.609	0.9583	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C07:29	SPMPPTRTL	0.5974	0.9562	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:14	SPMPPTRTL	0.5947	0.947	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C04:06	SPMPPTRTL	0.5678	0.8397	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C12:12	SPMPPTRTL	0.5551	0.8897	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C07:95	SPMPPTRTL	0.549	0.6929	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C07:27	SPMPPTRTL	0.544	0.945	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C01:30	MPPTRTLVM	0.5084	0.9788	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C07:80	SPMPPTRTL	0.4739	0.8996	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C07:67	SPMPPTRTL	0.4739	0.8996	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C07:10	SPMPPTRTL	0.4706	0.8982	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C07:46	SPMPPTRTL	0.4527	0.7981	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C01:30	SPMPPTRTL	0.4378	0.9657	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C04:14	SPMPPTRTL	0.4314	0.814	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C01:17	SPMPPTRTL	0.3866	0.9554	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C07:19	SPMPPTRTL	0.3749	0.6516	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C12:16	SPMPPTRTL	0.3665	0.9549	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C04:14	MPPTRTLVM	0.3145	0.9259	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C06:03	SPMPPTRTL	0.2617	0.9864	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C12:04	SPMPPTRTL	0.249	0.9864	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C01:17	MPPTRTLVM	0.1387	0.9764	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C08:15	SPMPPTRTL	0.0434	0.9557	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C04:10	SPMPPTRTL	0.0255	0.7929	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C04:07	SPMPPTRTL	0.0243	0.8379	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C12:12	SSPMPPTRTL	0.9976	0.8874	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:08	SSPMPPTRTL	0.9969	0.8857	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:07	SSPMPPTRTL	0.9963	0.9095	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C12:04	SSPMPPTRTL	0.9962	0.9873	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C06:03	SSPMPPTRTL	0.9961	0.9875	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:19	SSPMPPTRTL	0.9959	0.9692	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C15:04	SSPMPPTRTL	0.9956	0.7748	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C15:06	SSPMPPTRTL	0.9916	0.8184	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C02:06	SSPMPPTRTL	0.9799	0.9216	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B14:03	SSPMPPTRTL	0.9796	0.8548	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B51:07	SPMPPTRTLV	0.9624	0.6556	9	19
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B07:12	SSPMPPTRTL	0.9587	0.5533	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C01:17	SSPMPPTRTL	0.948	0.9474	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C01:30	SSPMPPTRTL	0.9443	0.9663	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B42:02	SSPMPPTRTL	0.9272	0.5266	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C07:29	SSPMPPTRTL	0.9241	0.9576	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B42:01	SSPMPPTRTL	0.914	0.5277	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:12	SSPMPPTRTL	0.8029	0.9372	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B39:10	SSPMPPTRTL	0.7286	0.9383	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B39:10	SPMPPTRTLV	0.7258	0.8786	9	19
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B07:12	SPMPPTRTLVM	0.9999	0.606	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B42:02	SPMPPTRTLVM	0.9987	0.6357	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:08	QSSPMPPTRTL	0.9985	0.9299	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C15:06	QSSPMPPTRTL	0.9985	0.9371	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B42:01	SPMPPTRTLVM	0.9982	0.6361	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B07:12	QSSPMPPTRTL	0.9954	0.8241	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B07:04	QSSPMPPTRTL	0.9946	0.5643	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B39:10	SPMPPTRTLVM	0.9893	0.9349	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:12	SPMPPTRTLVM	0.9876	0.9143	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B56:04	QSSPMPPTRTL	0.9805	0.5555	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C01:17	SSPMPPTRTLV	0.9761	0.9303	8	19
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:12	QSSPMPPTRTL	0.964	0.9798	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B42:02	QSSPMPPTRTL	0.9623	0.7935	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B42:01	QSSPMPPTRTL	0.9577	0.7864	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B78:01	QSSPMPPTRTL	0.9482	0.5315	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B39:10	QSSPMPPTRTL	0.9356	0.9764	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B07:12	SSPMPPTRTLV	0.9336	0.5227	8	19
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B07:09	SPMPPTRT	0.999	0.5136	9	17
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B78:02	MPPTRTLV	0.9983	0.6089	11	19
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C01:02	PMPPTRTL	0.9755	0.9691	10	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B07:09	PMPPTRTL	0.9671	0.5095	10	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C01:03	PMPPTRTL	0.9545	0.9655	10	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B67:01	PMPPTRTL	0.8952	0.9095	10	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B07:13	SPMPPTRTL	0.9998	0.8322	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B08:18	MPPTRTLVM	0.9951	0.5551	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:05	SPMPPTRTL	0.9933	0.9181	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:23	MPPTRTLVM	0.9921	0.9501	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:77	MPPTRTLVM	0.9919	0.9511	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:17	SPMPPTRTL	0.9906	0.9548	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:04	SPMPPTRTL	0.9877	0.9711	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:03	SPMPPTRTL	0.9877	0.9711	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:67	SPMPPTRTL	0.986	0.9591	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:67	MPPTRTLVM	0.985	0.9853	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:13	SPMPPTRTL	0.9827	0.8884	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:11	MPPTRTLVM	0.98	0.9546	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:24	MPPTRTLVM	0.9792	0.9391	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:13	MPPTRTLVM	0.9784	0.9322	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:17	MPPTRTLVM	0.9783	0.8515	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:30	MPPTRTLVM	0.9783	0.8515	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:17	MPPTRTLVM	0.9777	0.985	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:23	SPMPPTRTL	0.9712	0.8463	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:77	SPMPPTRTL	0.9712	0.8761	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B08:12	MPPTRTLVM	0.9688	0.7391	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:20	SPMPPTRTL	0.9562	0.8837	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B67:01	SPMPPTRTL	0.9558	0.8363	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-A74:01	QSSPMPPTR	0.9467	0.8061	7	16
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B39:31	SPMPPTRTL	0.9464	0.9175	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B08:18	SPMPPTRTL	0.9352	0.5203	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B39:02	SPMPPTRTL	0.9318	0.9269	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:09	SPMPPTRTL	0.929	0.9141	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:30	SPMPPTRTL	0.9212	0.6721	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:17	SPMPPTRTL	0.9212	0.6721	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-A66:02	QSSPMPPTR	0.9158	0.5848	7	16
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:11	SPMPPTRTL	0.9002	0.8955	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:02	SPMPPTRTL	0.8867	0.9555	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B08:12	SPMPPTRTL	0.8764	0.7224	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:24	SPMPPTRTL	0.8746	0.9052	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C06:08	SPMPPTRTL	0.87	0.9826	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:09	MPPTRTLVM	0.8386	0.9724	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B67:01	MPPTRTLVM	0.8284	0.9475	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C08:01	SPMPPTRTL	0.8185	0.9657	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B39:11	SPMPPTRTL	0.7788	0.8524	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B78:02	MPPTRTLVM	0.774	0.5528	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:06	SPMPPTRTL	0.7617	0.971	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C07:04	SPMPPTRTL	0.6855	0.9317	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C16:04	SPMPPTRTL	0.6768	0.972	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C07:17	SPMPPTRTL	0.6542	0.9607	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C15:05	SPMPPTRTL	0.6333	0.807	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B38:05	SPMPPTRTL	0.5992	0.959	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C07:22	SPMPPTRTL	0.5672	0.729	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C16:01	SPMPPTRTL	0.5571	0.9737	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C04:04	SPMPPTRTL	0.5532	0.8145	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C16:02	SPMPPTRTL	0.5315	0.9885	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C07:01	SPMPPTRTL	0.4986	0.6616	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C12:03	SPMPPTRTL	0.4899	0.9624	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C07:02	SPMPPTRTL	0.4739	0.8996	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C06:06	SPMPPTRTL	0.4523	0.9872	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C01:02	SPMPPTRTL	0.3851	0.9544	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C12:02	SPMPPTRTL	0.3533	0.9657	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C14:03	SPMPPTRTL	0.3481	0.9641	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C14:02	SPMPPTRTL	0.3481	0.9641	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-A69:01	SPMPPTRTL	0.3417	0.758	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B18:07	MPPTRTLVM	0.3085	0.93	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C06:17	SPMPPTRTL	0.2649	0.9856	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C06:02	SPMPPTRTL	0.2649	0.9856	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B18:04	SPMPPTRTL	0.203	0.9148	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-A25:01	SPMPPTRTL	0.1053	0.7706	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C01:03	SPMPPTRTL	0.1037	0.921	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:43	MPPTRTLVM	0.0963	0.9454	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B15:08	MPPTRTLVM	0.0894	0.9423	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B15:11	MPPTRTLVM	0.088	0.9438	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C01:02	MPPTRTLVM	0.0688	0.975	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B18:07	SPMPPTRTL	0.0632	0.8841	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C17:01	SPMPPTRTL	0.0606	0.6959	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B18:03	SPMPPTRTL	0.0462	0.9005	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C08:02	SPMPPTRTL	0.0434	0.9557	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C18:01	SPMPPTRTL	0.0345	0.8219	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:43	SPMPPTRTL	0.0266	0.8625	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C04:03	SPMPPTRTL	0.0256	0.858	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C04:01	SPMPPTRTL	0.0243	0.8379	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B15:08	SPMPPTRTL	0.0225	0.8579	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B15:11	SPMPPTRTL	0.0195	0.8497	9	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C01:03	MPPTRTLVM	0.0088	0.924	11	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:05	SSPMPPTRTL	0.9976	0.9399	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:03	SSPMPPTRTL	0.9975	0.9752	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:04	SSPMPPTRTL	0.9975	0.9752	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C12:03	SSPMPPTRTL	0.9975	0.9695	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:17	SSPMPPTRTL	0.9975	0.9604	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:67	SSPMPPTRTL	0.9965	0.9652	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C15:09	SSPMPPTRTL	0.9956	0.7748	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C16:04	SSPMPPTRTL	0.9943	0.9787	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C15:05	SSPMPPTRTL	0.9896	0.8322	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C15:02	SSPMPPTRTL	0.9889	0.7741	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B15:11	SSPMPPTRTL	0.9864	0.8898	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B15:08	SSPMPPTRTL	0.9851	0.8907	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:43	SSPMPPTRTL	0.9822	0.8944	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C16:01	SSPMPPTRTL	0.9768	0.9744	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B78:02	SPMPPTRTLV	0.9742	0.5043	9	19
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B07:13	SSPMPPTRTL	0.9667	0.8388	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B58:06	SSPMPPTRTL	0.9648	0.7255	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:11	SSPMPPTRTL	0.9637	0.911	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C16:02	SSPMPPTRTL	0.9603	0.9875	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C01:03	SSPMPPTRTL	0.9544	0.9092	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C03:06	SSPMPPTRTL	0.9542	0.9747	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B57:02	SSPMPPTRTL	0.9443	0.8917	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C01:02	SSPMPPTRTL	0.9372	0.9465	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:13	SSPMPPTRTL	0.8966	0.9203	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:17	SSPMPPTRTL	0.8779	0.699	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:30	SSPMPPTRTL	0.8779	0.699	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B08:12	SSPMPPTRTL	0.8619	0.7346	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C17:01	SSPMPPTRTL	0.8521	0.6673	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:09	SSPMPPTRTL	0.8029	0.9372	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B67:01	SPMPPTRTLV	0.7732	0.7489	9	19
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B67:01	SSPMPPTRTL	0.7149	0.8585	8	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C01:02	QSSPMPPTRTL	0.9995	0.9766	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B58:06	QSSPMPPTRTL	0.9984	0.9377	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:77	SPMPPTRTLVM	0.9981	0.8074	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:23	SPMPPTRTLVM	0.9979	0.7951	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B08:18	SPMPPTRTLVM	0.9979	0.6352	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B07:09	QSSPMPPTRTL	0.9971	0.6379	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:13	SPMPPTRTLVM	0.997	0.8093	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B07:22	QSSPMPPTRTL	0.9969	0.6158	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B57:02	QSSPMPPTRTL	0.9956	0.9453	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:30	SPMPPTRTLVM	0.9954	0.5939	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:17	SPMPPTRTLVM	0.9954	0.5939	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B07:26	QSSPMPPTRTL	0.9949	0.5868	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B67:01	SPMPPTRTLVM	0.991	0.8512	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B08:12	SPMPPTRTLVM	0.9896	0.7711	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:11	SPMPPTRTLVM	0.9896	0.8552	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:09	SPMPPTRTLVM	0.9876	0.9143	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B15:08	SPMPPTRTLVM	0.9874	0.8502	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:24	SPMPPTRTLVM	0.9869	0.813	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B15:11	SPMPPTRTLVM	0.9852	0.8685	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:43	SPMPPTRTLVM	0.9835	0.8526	9	20
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B56:02	QSSPMPPTRTL	0.9805	0.5555	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:13	QSSPMPPTRTL	0.9796	0.9593	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-C01:02	SSPMPPTRTLV	0.9782	0.9288	8	19
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:09	QSSPMPPTRTL	0.964	0.9798	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B35:22	QSSPMPPTRTL	0.9605	0.6081	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B67:01	QSSPMPPTRTL	0.9478	0.9698	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B55:04	QSSPMPPTRTL	0.9238	0.7223	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B82:02	QSSPMPPTRTL	0.9151	0.5777	7	18
RGS20-MCPH1	chr8	54792162	chr8	6335115	602	HLA-B67:01	SSPMPPTRTLV	0.7327	0.8578	8	19
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-B35:03	LPTRTLVM	0.977	0.8305	12	20
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-B35:02	LPTRTLVM	0.8164	0.9258	12	20
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-B35:04	LPTRTLVM	0.8164	0.9258	12	20
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-A31:06	RVDGGLPTR	0.9815	0.7457	7	16
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-A74:09	RVDGGLPTR	0.9812	0.8016	7	16
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-A74:11	RVDGGLPTR	0.9812	0.8016	7	16
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-A74:03	RVDGGLPTR	0.9812	0.8016	7	16
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-A03:12	RVDGGLPTR	0.919	0.5501	7	16
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-A31:02	RVDGGLPTR	0.9183	0.8084	7	16
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-A03:25	RVDGGLPTR	0.9182	0.5275	7	16
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-B27:05	GRVDGGLPTR	0.9999	0.5723	6	16
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-B35:12	LPTRTLVM	0.8164	0.9258	12	20
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-B39:10	LPTRTLVM	0.8151	0.8359	12	20
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-A31:01	RVDGGLPTR	0.9796	0.7714	7	16
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-A03:01	RVDGGLPTR	0.9182	0.5275	7	16
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-C01:30	GLPTRTLVM	0.466	0.9412	11	20
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-C01:17	GLPTRTLVM	0.2568	0.9429	11	20
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-B27:14	GRVDGGLPTR	0.9999	0.6532	6	16
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-B27:03	GRVDGGLPTR	0.9976	0.614	6	16
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-C08:15	RVDGGLPTRTL	1	0.9836	7	18
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-C05:09	RVDGGLPTRTL	1	0.9763	7	18
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-A02:07	RVDGGLPTRTL	0.8629	0.5174	7	18
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-B35:30	LPTRTLVM	0.9806	0.6629	12	20
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-B35:17	LPTRTLVM	0.9806	0.6629	12	20
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-B08:12	LPTRTLVM	0.9653	0.5738	12	20
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-B35:11	LPTRTLVM	0.9627	0.9228	12	20
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-B35:24	LPTRTLVM	0.9264	0.8096	12	20
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-B35:09	LPTRTLVM	0.8164	0.9258	12	20
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-A74:01	RVDGGLPTR	0.9812	0.8016	7	16
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-C01:02	GLPTRTLVM	0.2353	0.9423	11	20
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-C01:03	GLPTRTLVM	0.1418	0.9327	11	20
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-B27:08	GRVDGGLPTR	0.9998	0.5366	6	16
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-B27:10	GRVDGGLPTR	0.9997	0.7747	6	16
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-C08:02	RVDGGLPTRTL	1	0.9836	7	18
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-C04:03	RVDGGLPTRTL	1	0.9692	7	18
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-C05:01	RVDGGLPTRTL	1	0.9763	7	18
RGS20-MCPH1	chr8	54793644	chr8	6335115	191	HLA-B07:13	RVDGGLPTRTL	0.9915	0.8993	7	18
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:04	GRVDGGLVL	0.9994	0.8794	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:07	GRVDGGLVL	0.9994	0.8876	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:02	GRVDGGLVL	0.9992	0.68	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:05	GRVDGGLVL	0.9991	0.8717	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B57:01	RVDGGLVLW	0.9979	0.9962	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B39:24	GRVDGGLVL	0.9977	0.8431	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B39:01	GRVDGGLVL	0.9976	0.9352	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B58:01	RVDGGLVLW	0.9974	0.994	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B39:06	GRVDGGLVL	0.9953	0.9227	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B38:02	GRVDGGLVL	0.994	0.9785	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B58:02	RVDGGLVLW	0.9937	0.9908	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B38:01	GRVDGGLVL	0.9933	0.9815	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-A31:08	RVDGGLVLW	0.986	0.8888	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-A32:13	RVDGGLVLW	0.9781	0.9865	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B14:02	GRVDGGLVL	0.9769	0.8873	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B14:01	GRVDGGLVL	0.9769	0.8873	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B57:03	RVDGGLVLW	0.9747	0.9982	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B15:17	RVDGGLVLW	0.9721	0.985	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B15:16	RVDGGLVLW	0.9478	0.9847	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B15:10	GRVDGGLVL	0.9348	0.7012	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-A02:16	GLVLWSLEL	0.9011	0.6851	11	20
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-A24:17	RVDGGLVLW	0.898	0.6919	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B48:01	GRVDGGLVL	0.8708	0.9647	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-A02:04	GLVLWSLEL	0.8519	0.9078	11	20
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-A02:17	GLVLWSLEL	0.8232	0.881	11	20
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B15:18	GRVDGGLVL	0.7318	0.8763	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B53:01	RVDGGLVLW	0.7293	0.8386	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B15:37	GRVDGGLVL	0.6838	0.6708	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-A24:14	RVDGGLVLW	0.4885	0.5788	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B13:01	RVDGGLVLW	0.0681	0.9957	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B07:10	GRVDGGLVL	0.0536	0.6948	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:05	GRVDGGLVLW	0.9999	0.6258	6	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:04	GRVDGGLVLW	0.9998	0.759	6	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:04	AGRVDGGLVL	0.9966	0.8494	5	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:05	AGRVDGGLVL	0.9963	0.8247	5	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:02	AGRVDGGLVL	0.9962	0.5847	5	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:07	AGRVDGGLVL	0.9933	0.8972	5	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B07:10	AGRVDGGLVL	0.9795	0.7604	5	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B39:01	AGRVDGGLVL	0.7548	0.9272	5	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B57:01	AGRVDGGLVLW	1	0.9824	5	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B58:01	AGRVDGGLVLW	0.9997	0.9791	5	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C04:10	RVDGGLVL	1	0.9776	7	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C08:15	RVDGGLVL	1	0.9928	7	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C05:09	RVDGGLVL	1	0.9864	7	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C04:07	RVDGGLVL	1	0.9778	7	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C04:06	RVDGGLVL	0.9995	0.9811	7	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C08:13	RVDGGLVL	0.9982	0.9935	7	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C08:04	RVDGGLVL	0.9982	0.9935	7	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C08:03	RVDGGLVL	0.9121	0.9957	7	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:14	GRVDGGLVL	0.9992	0.8551	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B39:09	GRVDGGLVL	0.9978	0.8877	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C07:95	GRVDGGLVL	0.997	0.7968	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B39:12	GRVDGGLVL	0.9966	0.9362	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C07:13	GRVDGGLVL	0.9945	0.9617	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B39:05	GRVDGGLVL	0.9936	0.9248	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C07:27	GRVDGGLVL	0.9936	0.9708	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C07:05	GRVDGGLVL	0.9929	0.9762	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C05:09	RVDGGLVLW	0.9929	0.9864	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C07:29	GRVDGGLVL	0.9903	0.9136	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:03	GRVDGGLVL	0.973	0.8908	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C07:10	GRVDGGLVL	0.9672	0.9799	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C07:46	GRVDGGLVL	0.9657	0.9247	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C07:19	GRVDGGLVL	0.9567	0.8103	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C07:80	GRVDGGLVL	0.956	0.9623	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C07:67	GRVDGGLVL	0.956	0.9623	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B73:01	GRVDGGLVL	0.8362	0.845	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B44:08	RVDGGLVLW	0.566	0.8663	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B48:03	GRVDGGLVL	0.5246	0.917	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B44:06	RVDGGLVLW	0.4095	0.5935	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C12:16	GRVDGGLVL	0.0849	0.975	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:03	GRVDGGLVLW	0.9987	0.6486	6	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:14	AGRVDGGLVL	0.9966	0.8148	5	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:03	AGRVDGGLVL	0.9312	0.8461	5	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B39:12	AGRVDGGLVL	0.7149	0.9301	5	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C05:09	RVDGGLVLWSL	1	0.9607	7	18
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C08:15	RVDGGLVLWSL	1	0.9936	7	18
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-A02:07	RVDGGLVLWSL	0.9068	0.5259	7	18
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C08:02	RVDGGLVL	1	0.9928	7	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C04:03	RVDGGLVL	1	0.9797	7	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C18:01	RVDGGLVL	1	0.9766	7	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C05:01	RVDGGLVL	1	0.9864	7	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C04:01	RVDGGLVL	1	0.9778	7	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B07:13	RVDGGLVL	0.9427	0.8398	7	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C08:01	RVDGGLVL	0.9121	0.9957	7	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:06	GRVDGGLVL	0.9994	0.8525	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:10	GRVDGGLVL	0.9993	0.9043	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:08	GRVDGGLVL	0.9992	0.8586	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:09	GRVDGGLVL	0.9992	0.8527	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B57:10	RVDGGLVLW	0.9979	0.9962	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B39:02	GRVDGGLVL	0.9978	0.9562	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B39:31	GRVDGGLVL	0.9978	0.9356	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C07:01	GRVDGGLVL	0.9975	0.7787	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B57:04	RVDGGLVLW	0.9957	0.8709	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B38:05	GRVDGGLVL	0.9933	0.9815	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C05:01	RVDGGLVLW	0.9929	0.9864	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C04:03	RVDGGLVLW	0.9919	0.971	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-A32:01	RVDGGLVLW	0.9877	0.9894	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C07:17	GRVDGGLVL	0.9874	0.975	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C06:08	GRVDGGLVL	0.9777	0.9911	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B58:06	RVDGGLVLW	0.9755	0.9837	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B57:02	RVDGGLVLW	0.9678	0.9905	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C07:02	GRVDGGLVL	0.956	0.9623	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C06:06	GRVDGGLVL	0.902	0.9924	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C07:22	GRVDGGLVL	0.8734	0.7882	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B39:11	GRVDGGLVL	0.8707	0.9313	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C07:04	GRVDGGLVL	0.8489	0.9802	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C03:67	GRVDGGLVL	0.839	0.9873	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B15:09	GRVDGGLVL	0.8248	0.8604	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B15:13	RVDGGLVLW	0.7786	0.9757	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B40:12	GRVDGGLVL	0.5246	0.917	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B15:24	RVDGGLVLW	0.3427	0.9896	7	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C06:02	GRVDGGLVL	0.1735	0.9924	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C06:17	GRVDGGLVL	0.1735	0.9924	6	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:10	GRVDGGLVLW	0.9998	0.8106	6	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:08	GRVDGGLVLW	0.9998	0.5749	6	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:09	GRVDGGLVLW	0.9989	0.6136	6	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:10	AGRVDGGLVL	0.9966	0.8956	5	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:08	AGRVDGGLVL	0.9962	0.7946	5	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B57:04	GRVDGGLVLW	0.996	0.9187	6	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:06	AGRVDGGLVL	0.9951	0.8043	5	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B27:09	AGRVDGGLVL	0.9937	0.8238	5	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B57:02	GRVDGGLVLW	0.9806	0.9866	6	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C07:01	AGRVDGGLVL	0.9486	0.737	5	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B39:31	AGRVDGGLVL	0.7478	0.9287	5	15
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C05:01	RVDGGLVLWSL	1	0.9607	7	18
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C04:03	RVDGGLVLWSL	1	0.9564	7	18
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B57:04	AGRVDGGLVLW	1	0.8925	5	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B57:10	AGRVDGGLVLW	1	0.9824	5	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-C08:02	RVDGGLVLWSL	1	0.9936	7	18
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-B57:02	AGRVDGGLVLW	0.9997	0.9759	5	16
RGS20-MCPH1	chr8	54793644	chr8	6357373	191	HLA-A02:14	RVDGGLVLWSL	0.9297	0.5937	7	18

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Potential FusionNeoAntigen Information of RGS20-MCPH1 in HLA II

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene

Hchr

Hbp

Tgene

Tchr

Tbp

HLA II

FusionNeoAntigen peptide

Neoantigen start (at BP 13)

Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of RGS20-MCPH1

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
3065	GQSSPMPPTRTLVM	RGS20	MCPH1	chr8	54792162	chr8	6335115	602

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
3102	GRVDGGLPTRTLVM	RGS20	MCPH1	chr8	54793644	chr8	6335115	191

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
3103	GRVDGGLVLWSLEL	RGS20	MCPH1	chr8	54793644	chr8	6357373	191

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of RGS20-MCPH1

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B52:01	3W39	3065	GQSSPMPPTRTLVM	-4.50853	-4.50853
HLA-B44:05	3DX8	3065	GQSSPMPPTRTLVM	-4.62231	-4.62231
HLA-B14:02	3BVN	3102	GRVDGGLPTRTLVM	-7.9962	-8.1096
HLA-B14:02	3BVN	3102	GRVDGGLPTRTLVM	-5.70842	-6.74372
HLA-B52:01	3W39	3102	GRVDGGLPTRTLVM	-6.83737	-6.95077
HLA-B52:01	3W39	3102	GRVDGGLPTRTLVM	-4.4836	-5.5189
HLA-A11:01	4UQ2	3102	GRVDGGLPTRTLVM	-10.0067	-10.1201
HLA-A11:01	4UQ2	3102	GRVDGGLPTRTLVM	-9.03915	-10.0745
HLA-A24:02	5HGA	3102	GRVDGGLPTRTLVM	-6.56204	-6.67544
HLA-A24:02	5HGA	3102	GRVDGGLPTRTLVM	-5.42271	-6.45801
HLA-B44:05	3DX8	3102	GRVDGGLPTRTLVM	-7.85648	-8.89178
HLA-B44:05	3DX8	3102	GRVDGGLPTRTLVM	-5.3978	-5.5112
HLA-A02:01	6TDR	3102	GRVDGGLPTRTLVM	-3.37154	-4.40684
HLA-B14:02	3BVN	3103	GRVDGGLVLWSLEL	-7.9962	-8.1096
HLA-B14:02	3BVN	3103	GRVDGGLVLWSLEL	-5.70842	-6.74372
HLA-B52:01	3W39	3103	GRVDGGLVLWSLEL	-6.83737	-6.95077
HLA-B52:01	3W39	3103	GRVDGGLVLWSLEL	-4.4836	-5.5189
HLA-A11:01	4UQ2	3103	GRVDGGLVLWSLEL	-10.0067	-10.1201
HLA-A11:01	4UQ2	3103	GRVDGGLVLWSLEL	-9.03915	-10.0745
HLA-A24:02	5HGA	3103	GRVDGGLVLWSLEL	-6.56204	-6.67544
HLA-A24:02	5HGA	3103	GRVDGGLVLWSLEL	-5.42271	-6.45801
HLA-B44:05	3DX8	3103	GRVDGGLVLWSLEL	-7.85648	-8.89178
HLA-B44:05	3DX8	3103	GRVDGGLVLWSLEL	-5.3978	-5.5112
HLA-A02:01	6TDR	3103	GRVDGGLVLWSLEL	-3.37154	-4.40684

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Vaccine Design for the FusionNeoAntigens of RGS20-MCPH1

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
RGS20-MCPH1	chr8	54792162	chr8	6335115	10	18	PMPPTRTL	CCTATGCCGCCAACAAGAACATTA
RGS20-MCPH1	chr8	54792162	chr8	6335115	11	19	MPPTRTLV	ATGCCGCCAACAAGAACATTAGTC
RGS20-MCPH1	chr8	54792162	chr8	6335115	11	20	MPPTRTLVM	ATGCCGCCAACAAGAACATTAGTCATG
RGS20-MCPH1	chr8	54792162	chr8	6335115	6	16	GQSSPMPPTR	GGGCAGAGCTCGCCTATGCCGCCAACAAGA
RGS20-MCPH1	chr8	54792162	chr8	6335115	7	16	QSSPMPPTR	CAGAGCTCGCCTATGCCGCCAACAAGA
RGS20-MCPH1	chr8	54792162	chr8	6335115	7	18	QSSPMPPTRTL	CAGAGCTCGCCTATGCCGCCAACAAGAACATTA
RGS20-MCPH1	chr8	54792162	chr8	6335115	8	18	SSPMPPTRTL	AGCTCGCCTATGCCGCCAACAAGAACATTA
RGS20-MCPH1	chr8	54792162	chr8	6335115	8	19	SSPMPPTRTLV	AGCTCGCCTATGCCGCCAACAAGAACATTAGTC
RGS20-MCPH1	chr8	54792162	chr8	6335115	9	17	SPMPPTRT	TCGCCTATGCCGCCAACAAGAACA
RGS20-MCPH1	chr8	54792162	chr8	6335115	9	18	SPMPPTRTL	TCGCCTATGCCGCCAACAAGAACATTA
RGS20-MCPH1	chr8	54792162	chr8	6335115	9	19	SPMPPTRTLV	TCGCCTATGCCGCCAACAAGAACATTAGTC
RGS20-MCPH1	chr8	54792162	chr8	6335115	9	20	SPMPPTRTLVM	TCGCCTATGCCGCCAACAAGAACATTAGTCATG
RGS20-MCPH1	chr8	54793644	chr8	6335115	11	20	GLPTRTLVM	GGGCTCCCAACAAGAACATTAGTCATG
RGS20-MCPH1	chr8	54793644	chr8	6335115	12	20	LPTRTLVM	CTCCCAACAAGAACATTAGTCATG
RGS20-MCPH1	chr8	54793644	chr8	6335115	6	16	GRVDGGLPTR	GGCAGGGTGGACGGTGGGCTCCCAACAAGA
RGS20-MCPH1	chr8	54793644	chr8	6335115	7	16	RVDGGLPTR	AGGGTGGACGGTGGGCTCCCAACAAGA
RGS20-MCPH1	chr8	54793644	chr8	6335115	7	18	RVDGGLPTRTL	AGGGTGGACGGTGGGCTCCCAACAAGAACATTA
RGS20-MCPH1	chr8	54793644	chr8	6357373	11	20	GLVLWSLEL	GGGCTCGTGCTATGGTCTTTAGAATTG
RGS20-MCPH1	chr8	54793644	chr8	6357373	5	15	AGRVDGGLVL	GCCGGCAGGGTGGACGGTGGGCTCGTGCTA
RGS20-MCPH1	chr8	54793644	chr8	6357373	5	16	AGRVDGGLVLW	GCCGGCAGGGTGGACGGTGGGCTCGTGCTATGG
RGS20-MCPH1	chr8	54793644	chr8	6357373	6	15	GRVDGGLVL	GGCAGGGTGGACGGTGGGCTCGTGCTA
RGS20-MCPH1	chr8	54793644	chr8	6357373	6	16	GRVDGGLVLW	GGCAGGGTGGACGGTGGGCTCGTGCTATGG
RGS20-MCPH1	chr8	54793644	chr8	6357373	7	15	RVDGGLVL	AGGGTGGACGGTGGGCTCGTGCTA
RGS20-MCPH1	chr8	54793644	chr8	6357373	7	16	RVDGGLVLW	AGGGTGGACGGTGGGCTCGTGCTATGG
RGS20-MCPH1	chr8	54793644	chr8	6357373	7	18	RVDGGLVLWSL	AGGGTGGACGGTGGGCTCGTGCTATGGTCTTTA

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene

Hchr

Hbp

Tchr

Tbp

Start in +/-13AA

End in +/-13AA

FusionNeoAntigen peptide

FusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of RGS20-MCPH1

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
SKCM	RGS20-MCPH1	chr8	54793644	ENST00000276500	chr8	6335115	ENST00000344683	TCGA-EB-A82B-01A
SKCM	RGS20-MCPH1	chr8	54793644	ENST00000276500	chr8	6357373	ENST00000344683	TCGA-EB-A82B-01A
SKCM	RGS20-MCPH1	chr8	54792162	ENST00000297313	chr8	6335115	ENST00000344683	TCGA-EB-A82B-01A

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Potential target of CAR-T therapy development for RGS20-MCPH1

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to RGS20-MCPH1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to RGS20-MCPH1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)