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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:RUNX1-DTD1

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RUNX1-DTD1
FusionPDB ID: 78652
FusionGDB2.0 ID: 78652
HgeneTgene
Gene symbol

RUNX1

DTD1

Gene ID

861

92675

Gene nameRUNX family transcription factor 1D-aminoacyl-tRNA deacylase 1
SynonymsAML1|AML1-EVI-1|AMLCR1|CBF2alpha|CBFA2|EVI-1|PEBP2aB|PEBP2alphaC20orf88|DTD|DUE-B|DUEB|HARS2|pqn-68
Cytomap

21q22.12

20p11.23

Type of geneprotein-codingprotein-coding
Descriptionrunt-related transcription factor 1AML1-EVI-1 fusion proteinPEA2-alpha BPEBP2-alpha BSL3-3 enhancer factor 1 alpha B subunitSL3/AKV core-binding factor alpha B subunitacute myeloid leukemia 1 proteincore-binding factor, runt domain, alpha subunit 2D-aminoacyl-tRNA deacylase 1D-tyrosyl-tRNA deacylase 1 homologD-tyrosyl-tRNA(Tyr) deacylase 1DNA-unwinding element-binding protein Bgly-tRNA(Ala) deacylasehistidyl-tRNA synthase-relatedhistidyl-tRNA synthetase 2
Modification date2020032220200313
UniProtAcc

Q06455

Main function of 5'-partner protein: FUNCTION: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199, PubMed:10688654). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588). {ECO:0000250|UniProtKB:Q61909, ECO:0000269|PubMed:10688654, ECO:0000269|PubMed:10973986, ECO:0000269|PubMed:16803958, ECO:0000269|PubMed:23251453, ECO:0000269|PubMed:23812588, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.

Q8TEA8

Main function of 5'-partner protein: FUNCTION: Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034). {ECO:0000269|PubMed:15653697, ECO:0000269|PubMed:20065034}.; FUNCTION: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. {ECO:0000250|UniProtKB:Q8IIS0}.
Ensembl transtripts involved in fusion geneENST idsENST00000300305, ENST00000325074, 
ENST00000344691, ENST00000358356, 
ENST00000399240, ENST00000437180, 
ENST00000486278, ENST00000494829, 
ENST00000494921, ENST00000377452, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score46 X 68 X 13=4066413 X 8 X 8=832
# samples 8918
** MAII scorelog2(89/40664*10)=-5.51380298959468
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/832*10)=-2.20858662181142
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: RUNX1 [Title/Abstract] AND DTD1 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: RUNX1 [Title/Abstract] AND DTD1 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RUNX1(36252854)-DTD1(18724744), # samples:3
Anticipated loss of major functional domain due to fusion event.RUNX1-DTD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RUNX1-DTD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RUNX1-DTD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RUNX1-DTD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RUNX1-DTD1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
RUNX1-DTD1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
RUNX1-DTD1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRUNX1

GO:0030097

hemopoiesis

21873977

HgeneRUNX1

GO:0045893

positive regulation of transcription, DNA-templated

10207087|14970218

HgeneRUNX1

GO:0045944

positive regulation of transcription by RNA polymerase II

9199349|10207087|14970218|21873977



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:36252854/chr20:18724744)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across RUNX1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DTD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000437180RUNX1chr2136252854-ENST00000377452DTD1chr2018724744+1428698190747185

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000437180ENST00000377452RUNX1chr2136252854-DTD1chr2018724744+0.0141829080.985817

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for RUNX1-DTD1

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
RUNX1chr2136252854DTD1chr2018724744698169RFNDLRFVGRSGRAVKARKTAAEERK

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Potential FusionNeoAntigen Information of RUNX1-DTD1 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
RUNX1-DTD1_36252854_18724744.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
RUNX1-DTD1chr2136252854chr2018724744698HLA-A30:08RSGRAVKARK0.99360.7282919
RUNX1-DTD1chr2136252854chr2018724744698HLA-B27:14GRSGRAVKA0.99620.5876817
RUNX1-DTD1chr2136252854chr2018724744698HLA-A30:01SGRAVKARK0.98490.84231019
RUNX1-DTD1chr2136252854chr2018724744698HLA-A30:01VGRSGRAVK0.9830.8248716
RUNX1-DTD1chr2136252854chr2018724744698HLA-A30:01RSGRAVKARK0.99340.8832919
RUNX1-DTD1chr2136252854chr2018724744698HLA-A30:01RFVGRSGRAVK0.98150.89516

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Potential FusionNeoAntigen Information of RUNX1-DTD1 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
RUNX1-DTD1_36252854_18724744.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0103DLRFVGRSGRAVKAR318
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0103NDLRFVGRSGRAVKA217
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0103LRFVGRSGRAVKARK419
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0103FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0437GRAVKARKTAAEERK1126
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0801GRAVKARKTAAEERK1126
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0804GRAVKARKTAAEERK1126
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0806GRAVKARKTAAEERK1126
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0806SGRAVKARKTAAEER1025
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0806RSGRAVKARKTAAEE924
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0808GRAVKARKTAAEERK1126
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0808SGRAVKARKTAAEER1025
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0810GRAVKARKTAAEERK1126
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0810SGRAVKARKTAAEER1025
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0811GRAVKARKTAAEERK1126
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0811SGRAVKARKTAAEER1025
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0812GRAVKARKTAAEERK1126
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0812SGRAVKARKTAAEER1025
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0816GRAVKARKTAAEERK1126
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0822GRAVKARKTAAEERK1126
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0822SGRAVKARKTAAEER1025
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0822RSGRAVKARKTAAEE924
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0826GRAVKARKTAAEERK1126
RUNX1-DTD1chr2136252854chr2018724744698DRB1-0839GRAVKARKTAAEERK1126
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1102FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1116FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1121FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1136FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1148FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1165FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1186FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1186NDLRFVGRSGRAVKA217
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1301FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1308FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1315FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1316FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1316NDLRFVGRSGRAVKA217
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1317FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1319FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1320FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1322FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1327FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1327RFNDLRFVGRSGRAV015
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1335FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1351FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1352FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1353FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1357FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1359FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1361FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1364FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1367DLRFVGRSGRAVKAR318
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1367NDLRFVGRSGRAVKA217
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1368FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1369FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1370FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1371FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1371RFNDLRFVGRSGRAV015
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1372FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1376FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1378FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1379FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1380FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1383FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1384FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1387FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1391FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1392FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1398FNDLRFVGRSGRAVK116
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1415GRAVKARKTAAEERK1126
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1457GRAVKARKTAAEERK1126
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1457SGRAVKARKTAAEER1025
RUNX1-DTD1chr2136252854chr2018724744698DRB1-1478GRAVKARKTAAEERK1126

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Fusion breakpoint peptide structures of RUNX1-DTD1

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
2604FVGRSGRAVKARKTRUNX1DTD1chr2136252854chr2018724744698

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of RUNX1-DTD1

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B52:013W392604FVGRSGRAVKARKT-6.65674-6.65674
HLA-B44:053DX82604FVGRSGRAVKARKT-6.36866-6.36866

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Vaccine Design for the FusionNeoAntigens of RUNX1-DTD1

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
RUNX1-DTD1chr2136252854chr20187247441019SGRAVKARKGTGGAAGAGCTGTCAAAGCTCGAAAAA
RUNX1-DTD1chr2136252854chr2018724744516RFVGRSGRAVKGGTTTGTCGGTCGAAGTGGAAGAGCTGTCAAAG
RUNX1-DTD1chr2136252854chr2018724744716VGRSGRAVKTCGGTCGAAGTGGAAGAGCTGTCAAAG
RUNX1-DTD1chr2136252854chr2018724744817GRSGRAVKAGTCGAAGTGGAAGAGCTGTCAAAGCTC
RUNX1-DTD1chr2136252854chr2018724744919RSGRAVKARKGAAGTGGAAGAGCTGTCAAAGCTCGAAAAA

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
RUNX1-DTD1chr2136252854chr2018724744015RFNDLRFVGRSGRAVGATTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAGCTGTCA
RUNX1-DTD1chr2136252854chr2018724744116FNDLRFVGRSGRAVKTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAGCTGTCAAAG
RUNX1-DTD1chr2136252854chr20187247441025SGRAVKARKTAAEERGTGGAAGAGCTGTCAAAGCTCGAAAAACAGCAGCAGAGGAAAGAA
RUNX1-DTD1chr2136252854chr20187247441126GRAVKARKTAAEERKGAAGAGCTGTCAAAGCTCGAAAAACAGCAGCAGAGGAAAGAAAAG
RUNX1-DTD1chr2136252854chr2018724744217NDLRFVGRSGRAVKAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAGCTGTCAAAGCTC
RUNX1-DTD1chr2136252854chr2018724744318DLRFVGRSGRAVKARACCTCAGGTTTGTCGGTCGAAGTGGAAGAGCTGTCAAAGCTCGAA
RUNX1-DTD1chr2136252854chr2018724744419LRFVGRSGRAVKARKTCAGGTTTGTCGGTCGAAGTGGAAGAGCTGTCAAAGCTCGAAAAA
RUNX1-DTD1chr2136252854chr2018724744924RSGRAVKARKTAAEEGAAGTGGAAGAGCTGTCAAAGCTCGAAAAACAGCAGCAGAGGAAA

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Information of the samples that have these potential fusion neoantigens of RUNX1-DTD1

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
BRCARUNX1-DTD1chr2136252854ENST00000437180chr2018724744ENST00000377452TCGA-C8-A8HR-01A

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Potential target of CAR-T therapy development for RUNX1-DTD1

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to RUNX1-DTD1

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RUNX1-DTD1

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRUNX1C1832388Platelet Disorder, Familial, with Associated Myeloid Malignancy11CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneRUNX1C0023467Leukemia, Myelocytic, Acute4CGI;CTD_human;GENOMICS_ENGLAND
HgeneRUNX1C0026998Acute Myeloid Leukemia, M13CTD_human
HgeneRUNX1C1879321Acute Myeloid Leukemia (AML-M2)3CTD_human
HgeneRUNX1C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma2CTD_human
HgeneRUNX1C0003873Rheumatoid Arthritis1CTD_human
HgeneRUNX1C0006413Burkitt Lymphoma1ORPHANET
HgeneRUNX1C0017636Glioblastoma1CTD_human
HgeneRUNX1C0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgeneRUNX1C0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgeneRUNX1C0023473Myeloid Leukemia, Chronic1ORPHANET
HgeneRUNX1C0033578Prostatic Neoplasms1CTD_human
HgeneRUNX1C0040034Thrombocytopenia1GENOMICS_ENGLAND
HgeneRUNX1C0334588Giant Cell Glioblastoma1CTD_human
HgeneRUNX1C0349639Juvenile Myelomonocytic Leukemia1CTD_human
HgeneRUNX1C0376358Malignant neoplasm of prostate1CTD_human
HgeneRUNX1C1292769Precursor B-cell lymphoblastic leukemia1ORPHANET
HgeneRUNX1C1621958Glioblastoma Multiforme1CTD_human
HgeneRUNX1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneRUNX1C2713368Hematopoetic Myelodysplasia1CTD_human
HgeneRUNX1C3463824MYELODYSPLASTIC SYNDROME1CTD_human