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Fusion Protein:ATP5I-WHSC1 |
Fusion Gene and Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: ATP5I-WHSC1 | FusionPDB ID: 8006 | FusionGDB2.0 ID: 8006 | Hgene | Tgene | Gene symbol | ATP5I | WHSC1 | Gene ID | 521 | 7468 |
Gene name | ATP synthase membrane subunit e | nuclear receptor binding SET domain protein 2 | |
Synonyms | ATP5I|ATP5K | KMT3F|KMT3G|MMSET|REIIBP|TRX5|WHS|WHSC1 | |
Cytomap | 4p16.3 | 4p16.3 | |
Type of gene | protein-coding | protein-coding | |
Description | ATP synthase subunit e, mitochondrialATP synthase e chain, mitochondrialATP synthase, H+ transporting, mitochondrial F0 complex, subunit EATP synthase, H+ transporting, mitochondrial Fo complex subunit EATPase subunit eF1F0-ATP synthase, murine e sub | histone-lysine N-methyltransferase NSD2IL5 promoter REII region-binding proteinWolf-Hirschhorn syndrome candidate 1multiple myeloma SET domain containing protein type IIInuclear SET domain-containing protein 2probable histone-lysine N-methyltransfera | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | Q9UII2 Main function of 5'-partner protein: FUNCTION: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. {ECO:0000269|PubMed:12110673, ECO:0000269|PubMed:15528193, ECO:0000269|PubMed:19559621, ECO:0000269|PubMed:23135403}. | . | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000304312, ENST00000506525, | ENST00000382888, ENST00000398261, ENST00000420906, ENST00000436793, ENST00000482415, ENST00000503128, ENST00000514045, ENST00000382891, ENST00000382892, ENST00000382895, ENST00000508803, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 9 X 9 X 4=324 | 15 X 15 X 5=1125 |
# samples | 12 | 16 | |
** MAII score | log2(12/324*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/1125*10)=-2.81378119121704 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Fusion gene context | PubMed: ATP5I [Title/Abstract] AND WHSC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Fusion neoantigen context | PubMed: ATP5I [Title/Abstract] AND WHSC1 [Title/Abstract] AND neoantigen [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ATP5I(667700)-WHSC1(1936870), # samples:1 ATP5I(667701)-WHSC1(1936871), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | ATP5I-WHSC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATP5I-WHSC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATP5I-WHSC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ATP5I-WHSC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ATP5I | GO:0042776 | mitochondrial ATP synthesis coupled proton transport | 12110673 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:667700/chr4:1936870) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Amino Acid Sequences |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000304312 | ATP5I | chr4 | 667700 | - | ENST00000508803 | WHSC1 | chr4 | 1936870 | + | 2730 | 182 | 10 | 2724 | 904 |
ENST00000304312 | ATP5I | chr4 | 667700 | - | ENST00000382892 | WHSC1 | chr4 | 1936870 | + | 6019 | 182 | 10 | 2724 | 904 |
ENST00000304312 | ATP5I | chr4 | 667700 | - | ENST00000382891 | WHSC1 | chr4 | 1936870 | + | 6022 | 182 | 10 | 2724 | 904 |
ENST00000304312 | ATP5I | chr4 | 667700 | - | ENST00000382895 | WHSC1 | chr4 | 1936870 | + | 6023 | 182 | 10 | 2724 | 904 |
ENST00000304312 | ATP5I | chr4 | 667701 | - | ENST00000508803 | WHSC1 | chr4 | 1936871 | + | 2730 | 182 | 10 | 2724 | 904 |
ENST00000304312 | ATP5I | chr4 | 667701 | - | ENST00000382892 | WHSC1 | chr4 | 1936871 | + | 6019 | 182 | 10 | 2724 | 904 |
ENST00000304312 | ATP5I | chr4 | 667701 | - | ENST00000382891 | WHSC1 | chr4 | 1936871 | + | 6022 | 182 | 10 | 2724 | 904 |
ENST00000304312 | ATP5I | chr4 | 667701 | - | ENST00000382895 | WHSC1 | chr4 | 1936871 | + | 6023 | 182 | 10 | 2724 | 904 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000304312 | ENST00000508803 | ATP5I | chr4 | 667700 | - | WHSC1 | chr4 | 1936870 | + | 0.00086069 | 0.9991393 |
ENST00000304312 | ENST00000382892 | ATP5I | chr4 | 667700 | - | WHSC1 | chr4 | 1936870 | + | 0.000196782 | 0.99980325 |
ENST00000304312 | ENST00000382891 | ATP5I | chr4 | 667700 | - | WHSC1 | chr4 | 1936870 | + | 0.000196782 | 0.99980325 |
ENST00000304312 | ENST00000382895 | ATP5I | chr4 | 667700 | - | WHSC1 | chr4 | 1936870 | + | 0.000196289 | 0.9998037 |
ENST00000304312 | ENST00000508803 | ATP5I | chr4 | 667701 | - | WHSC1 | chr4 | 1936871 | + | 0.00086069 | 0.9991393 |
ENST00000304312 | ENST00000382892 | ATP5I | chr4 | 667701 | - | WHSC1 | chr4 | 1936871 | + | 0.000196782 | 0.99980325 |
ENST00000304312 | ENST00000382891 | ATP5I | chr4 | 667701 | - | WHSC1 | chr4 | 1936871 | + | 0.000196782 | 0.99980325 |
ENST00000304312 | ENST00000382895 | ATP5I | chr4 | 667701 | - | WHSC1 | chr4 | 1936871 | + | 0.000196289 | 0.9998037 |
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Get the fusion protein sequences from here. |
Fusion protein sequence information is available in the fasta format. >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP |
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Fusion Protein Breakpoint Sequences for ATP5I-WHSC1 |
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Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Length(fusion protein) | BP in fusion protein | Peptide |
ATP5I | chr4 | 667700 | WHSC1 | chr4 | 1936870 | 182 | 58 | LFLGVAYGATRYSNVNGKKRNHTKRI |
ATP5I | chr4 | 667701 | WHSC1 | chr4 | 1936871 | 182 | 58 | LFLGVAYGATRYSNVNGKKRNHTKRI |
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Potential FusionNeoAntigen Information of ATP5I-WHSC1 in HLA I |
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ATP5I-WHSC1_667700_1936870.msa |
![]() * We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5) |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA I | FusionNeoAntigen peptide | Binding score | Immunogenic score | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | HLA-B27:05 | TRYSNVNGK | 0.9973 | 0.8664 | 9 | 18 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | HLA-B27:04 | TRYSNVNGK | 0.9867 | 0.7192 | 9 | 18 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | HLA-A30:08 | ATRYSNVNGK | 0.997 | 0.7081 | 8 | 18 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | HLA-B27:05 | ATRYSNVNGK | 0.9184 | 0.8706 | 8 | 18 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | HLA-A30:08 | ATRYSNVNGKK | 0.9977 | 0.7264 | 8 | 19 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | HLA-B27:05 | GATRYSNVNGK | 0.993 | 0.8415 | 7 | 18 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | HLA-B27:14 | TRYSNVNGK | 0.9941 | 0.7577 | 9 | 18 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | HLA-B27:03 | TRYSNVNGK | 0.9025 | 0.8891 | 9 | 18 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | HLA-B27:14 | TRYSNVNGKK | 0.9986 | 0.7986 | 9 | 19 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | HLA-B27:14 | ATRYSNVNGK | 0.8051 | 0.8053 | 8 | 18 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | HLA-B27:03 | ATRYSNVNGK | 0.5174 | 0.8949 | 8 | 18 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | HLA-B27:14 | GATRYSNVNGK | 0.9758 | 0.7724 | 7 | 18 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | HLA-B27:03 | GATRYSNVNGK | 0.8645 | 0.8685 | 7 | 18 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | HLA-B27:08 | TRYSNVNGK | 0.9962 | 0.7544 | 9 | 18 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | HLA-B27:10 | TRYSNVNGK | 0.9947 | 0.8348 | 9 | 18 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | HLA-B27:10 | TRYSNVNGKK | 0.9984 | 0.8653 | 9 | 19 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | HLA-A30:01 | ATRYSNVNGK | 0.997 | 0.8137 | 8 | 18 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | HLA-B27:10 | ATRYSNVNGK | 0.8539 | 0.8035 | 8 | 18 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | HLA-A30:01 | ATRYSNVNGKK | 0.9975 | 0.8439 | 8 | 19 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | HLA-B27:10 | GATRYSNVNGK | 0.991 | 0.8259 | 7 | 18 |
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Potential FusionNeoAntigen Information of ATP5I-WHSC1 in HLA II |
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ATP5I-WHSC1_667700_1936870.msa |
![]() * We used NetMHCIIpan v4.1 (%rank<0.5). |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA II | FusionNeoAntigen peptide | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB1-1141 | YSNVNGKKRNHTKRI | 11 | 26 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB1-1141 | RYSNVNGKKRNHTKR | 10 | 25 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB1-1155 | YSNVNGKKRNHTKRI | 11 | 26 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB1-1155 | RYSNVNGKKRNHTKR | 10 | 25 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0101 | ATRYSNVNGKKRNHT | 8 | 23 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0101 | GATRYSNVNGKKRNH | 7 | 22 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0101 | YGATRYSNVNGKKRN | 6 | 21 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0101 | TRYSNVNGKKRNHTK | 9 | 24 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0102 | ATRYSNVNGKKRNHT | 8 | 23 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0102 | GATRYSNVNGKKRNH | 7 | 22 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0103 | ATRYSNVNGKKRNHT | 8 | 23 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0103 | GATRYSNVNGKKRNH | 7 | 22 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0103 | YGATRYSNVNGKKRN | 6 | 21 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0104 | ATRYSNVNGKKRNHT | 8 | 23 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0104 | GATRYSNVNGKKRNH | 7 | 22 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0104 | YGATRYSNVNGKKRN | 6 | 21 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0104 | TRYSNVNGKKRNHTK | 9 | 24 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0105 | ATRYSNVNGKKRNHT | 8 | 23 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0105 | GATRYSNVNGKKRNH | 7 | 22 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0105 | YGATRYSNVNGKKRN | 6 | 21 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0105 | TRYSNVNGKKRNHTK | 9 | 24 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0108N | ATRYSNVNGKKRNHT | 8 | 23 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0108N | GATRYSNVNGKKRNH | 7 | 22 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0111 | ATRYSNVNGKKRNHT | 8 | 23 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0111 | GATRYSNVNGKKRNH | 7 | 22 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0111 | YGATRYSNVNGKKRN | 6 | 21 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0113 | ATRYSNVNGKKRNHT | 8 | 23 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0113 | GATRYSNVNGKKRNH | 7 | 22 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0113 | YGATRYSNVNGKKRN | 6 | 21 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0113 | TRYSNVNGKKRNHTK | 9 | 24 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0114 | ATRYSNVNGKKRNHT | 8 | 23 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0114 | GATRYSNVNGKKRNH | 7 | 22 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0114 | YGATRYSNVNGKKRN | 6 | 21 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0114 | TRYSNVNGKKRNHTK | 9 | 24 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0203 | ATRYSNVNGKKRNHT | 8 | 23 |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 | DRB5-0203 | GATRYSNVNGKKRNH | 7 | 22 |
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Fusion breakpoint peptide structures of ATP5I-WHSC1 |
![]() * The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA. |
File name | BPseq | Hgene | Tgene | Hchr | Hbp | Tchr | Tbp | AAlen |
10640 | YGATRYSNVNGKKR | ATP5I | WHSC1 | chr4 | 667700 | chr4 | 1936870 | 182 |
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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ATP5I-WHSC1 |
![]() * We used Glide to predict the interaction between HLAs and neoantigens. |
HLA allele | PDB ID | File name | BPseq | Docking score | Glide score |
HLA-B14:02 | 3BVN | 10640 | YGATRYSNVNGKKR | -7.15543 | -7.26883 |
HLA-B14:02 | 3BVN | 10640 | YGATRYSNVNGKKR | -4.77435 | -5.80965 |
HLA-B52:01 | 3W39 | 10640 | YGATRYSNVNGKKR | -6.80875 | -6.92215 |
HLA-B52:01 | 3W39 | 10640 | YGATRYSNVNGKKR | -4.20386 | -5.23916 |
HLA-A11:01 | 4UQ2 | 10640 | YGATRYSNVNGKKR | -7.5194 | -8.5547 |
HLA-A11:01 | 4UQ2 | 10640 | YGATRYSNVNGKKR | -6.9601 | -7.0735 |
HLA-A24:02 | 5HGA | 10640 | YGATRYSNVNGKKR | -7.52403 | -7.63743 |
HLA-A24:02 | 5HGA | 10640 | YGATRYSNVNGKKR | -5.82433 | -6.85963 |
HLA-B27:05 | 6PYJ | 10640 | YGATRYSNVNGKKR | -3.28285 | -4.31815 |
HLA-B44:05 | 3DX8 | 10640 | YGATRYSNVNGKKR | -5.91172 | -6.94702 |
HLA-B44:05 | 3DX8 | 10640 | YGATRYSNVNGKKR | -4.24346 | -4.35686 |
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Vaccine Design for the FusionNeoAntigens of ATP5I-WHSC1 |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide sequence | FusionNeoAntigen RNA sequence |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 7 | 18 | GATRYSNVNGK | ACGGAGCCACGCGCTACAGTAATGTAAATGGGA |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 8 | 18 | ATRYSNVNGK | GAGCCACGCGCTACAGTAATGTAAATGGGA |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 8 | 19 | ATRYSNVNGKK | GAGCCACGCGCTACAGTAATGTAAATGGGAAAA |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 9 | 18 | TRYSNVNGK | CCACGCGCTACAGTAATGTAAATGGGA |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 9 | 19 | TRYSNVNGKK | CCACGCGCTACAGTAATGTAAATGGGAAAA |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide | FusionNEoAntigen RNA sequence |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 10 | 25 | RYSNVNGKKRNHTKR | CGCGCTACAGTAATGTAAATGGGAAAAAAAGAAACCACACAAAGA |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 11 | 26 | YSNVNGKKRNHTKRI | GCTACAGTAATGTAAATGGGAAAAAAAGAAACCACACAAAGAGGA |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 6 | 21 | YGATRYSNVNGKKRN | CCTACGGAGCCACGCGCTACAGTAATGTAAATGGGAAAAAAAGAA |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 7 | 22 | GATRYSNVNGKKRNH | ACGGAGCCACGCGCTACAGTAATGTAAATGGGAAAAAAAGAAACC |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 8 | 23 | ATRYSNVNGKKRNHT | GAGCCACGCGCTACAGTAATGTAAATGGGAAAAAAAGAAACCACA |
ATP5I-WHSC1 | chr4 | 667700 | chr4 | 1936870 | 9 | 24 | TRYSNVNGKKRNHTK | CCACGCGCTACAGTAATGTAAATGGGAAAAAAAGAAACCACACAA |
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Information of the samples that have these potential fusion neoantigens of ATP5I-WHSC1 |
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Cancer type | Fusion gene | Hchr | Hbp | Henst | Tchr | Tbp | Tenst | Sample |
OV | ATP5I-WHSC1 | chr4 | 667700 | ENST00000304312 | chr4 | 1936870 | ENST00000382891 | TCGA-24-1474 |
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Potential target of CAR-T therapy development for ATP5I-WHSC1 |
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![]() * Minus value of BPloci means that the break point is located before the CDS. |
- In-frame and retained 'Transmembrane'. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
![]() * We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image. |
Hgene | Hchr | Hbp | Henst | Tgene | Tchr | Tbp | Tenst | DeepLoc result |
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Related Drugs to ATP5I-WHSC1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to ATP5I-WHSC1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |