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Fusion Protein:ATP6V0A1-NBR1

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ATP6V0A1-NBR1
	FusionPDB ID: 8087
	FusionGDB2.0 ID: 8087
		Hgene	Tgene
	Gene symbol	ATP6V0A1	NBR1
	Gene ID	535	4077
	Gene name	ATPase H+ transporting V0 subunit a1	NBR1 autophagy cargo receptor
	Synonyms	ATP6N1\|ATP6N1A\|Stv1\|VPP1\|Vph1\|a1	1A1-3B\|IAI3B\|M17S2\|MIG19
	Cytomap	17q21.2	17q21.31
	Type of gene	protein-coding	protein-coding
	Description	V-type proton ATPase 116 kDa subunit a isoform 1V-type proton ATPase 116 kDa subunit aATPase, H+ transporting, lysosomal V0 subunit a1ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD)H(+)-transporting two-sector ATPase,	next to BRCA1 gene 1 proteinB-box proteincell migration-inducing gene 19 proteinmembrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125)migration-inducing protein 19neighbor of BRCA1 gene 1
	Modification date	20200324	20200313
	UniProtAcc	Q93050 Main function of 5'-partner protein: FUNCTION: Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). {ECO:0000250}.	Q14596 Main function of 5'-partner protein: FUNCTION: Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. {ECO:0000269\|PubMed:19250911}.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000264649, ENST00000343619, ENST00000393829, ENST00000537728, ENST00000544137, ENST00000546249, ENST00000585525, ENST00000587797,	ENST00000341165, ENST00000389312, ENST00000422280, ENST00000542611, ENST00000589872, ENST00000590996,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	20 X 17 X 9=3060	6 X 7 X 5=210
	# samples	22	7
	** MAII score	log2(22/3060*10)=-3.79795622405535 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: ATP6V0A1 [Title/Abstract] AND NBR1 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: ATP6V0A1 [Title/Abstract] AND NBR1 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ATP6V0A1(40659645)-NBR1(41338267), # samples:1
Anticipated loss of major functional domain due to fusion event.	ATP6V0A1-NBR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATP6V0A1-NBR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATP6V0A1-NBR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ATP6V0A1-NBR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NBR1	GO:0016236	macroautophagy	19250911

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:40659645/chr17:41338267)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across ATP6V0A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NBR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000393829	ATP6V0A1	chr17	40659645	+	ENST00000341165	NBR1	chr17	41338267	+	6588	2279	74	4972	1632
ENST00000393829	ATP6V0A1	chr17	40659645	+	ENST00000422280	NBR1	chr17	41338267	+	6586	2279	74	4972	1632
ENST00000393829	ATP6V0A1	chr17	40659645	+	ENST00000542611	NBR1	chr17	41338267	+	4728	2279	74	4648	1524
ENST00000393829	ATP6V0A1	chr17	40659645	+	ENST00000590996	NBR1	chr17	41338267	+	5420	2279	74	4972	1632
ENST00000393829	ATP6V0A1	chr17	40659645	+	ENST00000389312	NBR1	chr17	41338267	+	6586	2279	74	4972	1632
ENST00000393829	ATP6V0A1	chr17	40659645	+	ENST00000589872	NBR1	chr17	41338267	+	5100	2279	74	4885	1603
ENST00000546249	ATP6V0A1	chr17	40659645	+	ENST00000341165	NBR1	chr17	41338267	+	6588	2279	74	4972	1632
ENST00000546249	ATP6V0A1	chr17	40659645	+	ENST00000422280	NBR1	chr17	41338267	+	6586	2279	74	4972	1632
ENST00000546249	ATP6V0A1	chr17	40659645	+	ENST00000542611	NBR1	chr17	41338267	+	4728	2279	74	4648	1524
ENST00000546249	ATP6V0A1	chr17	40659645	+	ENST00000590996	NBR1	chr17	41338267	+	5420	2279	74	4972	1632
ENST00000546249	ATP6V0A1	chr17	40659645	+	ENST00000389312	NBR1	chr17	41338267	+	6586	2279	74	4972	1632
ENST00000546249	ATP6V0A1	chr17	40659645	+	ENST00000589872	NBR1	chr17	41338267	+	5100	2279	74	4885	1603
ENST00000537728	ATP6V0A1	chr17	40659645	+	ENST00000341165	NBR1	chr17	41338267	+	6425	2116	40	4809	1589
ENST00000537728	ATP6V0A1	chr17	40659645	+	ENST00000422280	NBR1	chr17	41338267	+	6423	2116	40	4809	1589
ENST00000537728	ATP6V0A1	chr17	40659645	+	ENST00000542611	NBR1	chr17	41338267	+	4565	2116	40	4485	1481
ENST00000537728	ATP6V0A1	chr17	40659645	+	ENST00000590996	NBR1	chr17	41338267	+	5257	2116	40	4809	1589
ENST00000537728	ATP6V0A1	chr17	40659645	+	ENST00000389312	NBR1	chr17	41338267	+	6423	2116	40	4809	1589
ENST00000537728	ATP6V0A1	chr17	40659645	+	ENST00000589872	NBR1	chr17	41338267	+	4937	2116	40	4722	1560
ENST00000264649	ATP6V0A1	chr17	40659645	+	ENST00000341165	NBR1	chr17	41338267	+	6573	2264	38	4957	1639
ENST00000264649	ATP6V0A1	chr17	40659645	+	ENST00000422280	NBR1	chr17	41338267	+	6571	2264	38	4957	1639
ENST00000264649	ATP6V0A1	chr17	40659645	+	ENST00000542611	NBR1	chr17	41338267	+	4713	2264	38	4633	1531
ENST00000264649	ATP6V0A1	chr17	40659645	+	ENST00000590996	NBR1	chr17	41338267	+	5405	2264	38	4957	1639
ENST00000264649	ATP6V0A1	chr17	40659645	+	ENST00000389312	NBR1	chr17	41338267	+	6571	2264	38	4957	1639
ENST00000264649	ATP6V0A1	chr17	40659645	+	ENST00000589872	NBR1	chr17	41338267	+	5085	2264	38	4870	1610
ENST00000585525	ATP6V0A1	chr17	40659645	+	ENST00000341165	NBR1	chr17	41338267	+	6415	2106	30	4799	1589
ENST00000585525	ATP6V0A1	chr17	40659645	+	ENST00000422280	NBR1	chr17	41338267	+	6413	2106	30	4799	1589
ENST00000585525	ATP6V0A1	chr17	40659645	+	ENST00000542611	NBR1	chr17	41338267	+	4555	2106	30	4475	1481
ENST00000585525	ATP6V0A1	chr17	40659645	+	ENST00000590996	NBR1	chr17	41338267	+	5247	2106	30	4799	1589
ENST00000585525	ATP6V0A1	chr17	40659645	+	ENST00000389312	NBR1	chr17	41338267	+	6413	2106	30	4799	1589
ENST00000585525	ATP6V0A1	chr17	40659645	+	ENST00000589872	NBR1	chr17	41338267	+	4927	2106	30	4712	1560
ENST00000343619	ATP6V0A1	chr17	40659645	+	ENST00000341165	NBR1	chr17	41338267	+	6544	2235	30	4928	1632
ENST00000343619	ATP6V0A1	chr17	40659645	+	ENST00000422280	NBR1	chr17	41338267	+	6542	2235	30	4928	1632
ENST00000343619	ATP6V0A1	chr17	40659645	+	ENST00000542611	NBR1	chr17	41338267	+	4684	2235	30	4604	1524
ENST00000343619	ATP6V0A1	chr17	40659645	+	ENST00000590996	NBR1	chr17	41338267	+	5376	2235	30	4928	1632
ENST00000343619	ATP6V0A1	chr17	40659645	+	ENST00000389312	NBR1	chr17	41338267	+	6542	2235	30	4928	1632
ENST00000343619	ATP6V0A1	chr17	40659645	+	ENST00000589872	NBR1	chr17	41338267	+	5056	2235	30	4841	1603
ENST00000544137	ATP6V0A1	chr17	40659645	+	ENST00000341165	NBR1	chr17	41338267	+	5496	1187	14	3880	1288
ENST00000544137	ATP6V0A1	chr17	40659645	+	ENST00000422280	NBR1	chr17	41338267	+	5494	1187	14	3880	1288
ENST00000544137	ATP6V0A1	chr17	40659645	+	ENST00000542611	NBR1	chr17	41338267	+	3636	1187	14	3556	1180
ENST00000544137	ATP6V0A1	chr17	40659645	+	ENST00000590996	NBR1	chr17	41338267	+	4328	1187	14	3880	1288
ENST00000544137	ATP6V0A1	chr17	40659645	+	ENST00000389312	NBR1	chr17	41338267	+	5494	1187	14	3880	1288
ENST00000544137	ATP6V0A1	chr17	40659645	+	ENST00000589872	NBR1	chr17	41338267	+	4008	1187	14	3793	1259

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000393829	ENST00000341165	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000176214	0.99982387
ENST00000393829	ENST00000422280	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000177738	0.9998223
ENST00000393829	ENST00000542611	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000244606	0.99975544
ENST00000393829	ENST00000590996	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000447436	0.99955255
ENST00000393829	ENST00000389312	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000177738	0.9998223
ENST00000393829	ENST00000589872	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.00041556	0.9995845
ENST00000546249	ENST00000341165	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000176214	0.99982387
ENST00000546249	ENST00000422280	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000177738	0.9998223
ENST00000546249	ENST00000542611	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000244606	0.99975544
ENST00000546249	ENST00000590996	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000447436	0.99955255
ENST00000546249	ENST00000389312	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000177738	0.9998223
ENST00000546249	ENST00000589872	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.00041556	0.9995845
ENST00000537728	ENST00000341165	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000157984	0.99984205
ENST00000537728	ENST00000422280	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000159207	0.99984074
ENST00000537728	ENST00000542611	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000207444	0.9997925
ENST00000537728	ENST00000590996	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000397194	0.99960285
ENST00000537728	ENST00000389312	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000159207	0.99984074
ENST00000537728	ENST00000589872	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000356061	0.9996439
ENST00000264649	ENST00000341165	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000178509	0.9998215
ENST00000264649	ENST00000422280	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000180059	0.99981993
ENST00000264649	ENST00000542611	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000254249	0.9997458
ENST00000264649	ENST00000590996	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000461012	0.999539
ENST00000264649	ENST00000389312	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000180059	0.99981993
ENST00000264649	ENST00000589872	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000429889	0.9995701
ENST00000585525	ENST00000341165	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000157067	0.9998429
ENST00000585525	ENST00000422280	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000158286	0.9998417
ENST00000585525	ENST00000542611	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000206457	0.9997936
ENST00000585525	ENST00000590996	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000396224	0.9996038
ENST00000585525	ENST00000389312	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000158286	0.9998417
ENST00000585525	ENST00000589872	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000355164	0.9996449
ENST00000343619	ENST00000341165	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000166671	0.99983335
ENST00000343619	ENST00000422280	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000168162	0.9998318
ENST00000343619	ENST00000542611	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000226705	0.9997733
ENST00000343619	ENST00000590996	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000417857	0.9995821
ENST00000343619	ENST00000389312	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000168162	0.9998318
ENST00000343619	ENST00000589872	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.00038566	0.99961436
ENST00000544137	ENST00000341165	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000152741	0.9998473
ENST00000544137	ENST00000422280	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000154227	0.99984574
ENST00000544137	ENST00000542611	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000272966	0.9997271
ENST00000544137	ENST00000590996	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000475587	0.9995245
ENST00000544137	ENST00000389312	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000154227	0.99984574
ENST00000544137	ENST00000589872	ATP6V0A1	chr17	40659645	+	NBR1	chr17	41338267	+	0.000430338	0.9995697

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for ATP6V0A1-NBR1

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Length(fusion protein)

BP in fusion protein

Peptide

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Potential FusionNeoAntigen Information of ATP6V0A1-NBR1 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene

Hchr

Hbp

Tgene

Tchr

Tbp

HLA I

FusionNeoAntigen peptide

Binding score

Immunogenic score

Neoantigen start (at BP 13)

Neoantigen end (at BP 13)

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Potential FusionNeoAntigen Information of ATP6V0A1-NBR1 in HLA II

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene

Hchr

Hbp

Tgene

Tchr

Tbp

HLA II

FusionNeoAntigen peptide

Neoantigen start (at BP 13)

Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of ATP6V0A1-NBR1

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ATP6V0A1-NBR1

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele

PDB ID

File name

BPseq

Docking score

Glide score

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Vaccine Design for the FusionNeoAntigens of ATP6V0A1-NBR1

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene

Hchr

Hbp

Tchr

Tbp

Start in +/-13AA

End in +/-13AA

FusionNeoAntigen peptide sequence

FusionNeoAntigen RNA sequence

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene

Hchr

Hbp

Tchr

Tbp

Start in +/-13AA

End in +/-13AA

FusionNeoAntigen peptide

FusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of ATP6V0A1-NBR1

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type

Fusion gene

Hchr

Hbp

Henst

Tchr

Tbp

Tenst

Sample

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Potential target of CAR-T therapy development for ATP6V0A1-NBR1

Predicted 3D structure. We used RoseTTAFold.

51_ATP6V0A1-NBR1_t000_.e2e.pdb

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATP6V0A1

chr17:40659645

chr17:41338267

ENST00000264649

389_407

711

839.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40659645

chr17:41338267

ENST00000264649

410_426

711

839.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40659645

chr17:41338267

ENST00000264649

442_471

711

839.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40659645

chr17:41338267

ENST00000264649

535_554

711

839.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40659645

chr17:41338267

ENST00000264649

573_593

711

839.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40659645

chr17:41338267

ENST00000264649

639_658

711

839.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40659645

chr17:41338267

ENST00000343619

389_407

704

838.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40659645

chr17:41338267

ENST00000343619

410_426

704

838.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40659645

chr17:41338267

ENST00000343619

442_471

704

838.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40659645

chr17:41338267

ENST00000343619

535_554

704

838.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40659645

chr17:41338267

ENST00000343619

573_593

704

838.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40659645

chr17:41338267

ENST00000343619

639_658

704

838.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40659645

chr17:41338267

ENST00000393829

389_407

704

832.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40659645

chr17:41338267

ENST00000393829

410_426

704

832.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40659645

chr17:41338267

ENST00000393829

442_471

704

832.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40659645

chr17:41338267

ENST00000393829

535_554

704

832.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40659645

chr17:41338267

ENST00000393829

573_593

704

832.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40659645

chr17:41338267

ENST00000393829

639_658

704

832.0

Transmembrane

Helical

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene	Hchr	Hbp	Henst	Tgene	Tchr	Tbp	Tenst	DeepLoc result
ATP6V0A1	chr17	40659645	ENST00000264649	NBR1	chr17	41338267	ENST00000341165
ATP6V0A1	chr17	40659645	ENST00000264649	NBR1	chr17	41338267	ENST00000542611
ATP6V0A1	chr17	40659645	ENST00000264649	NBR1	chr17	41338267	ENST00000589872
ATP6V0A1	chr17	40659645	ENST00000343619	NBR1	chr17	41338267	ENST00000341165
ATP6V0A1	chr17	40659645	ENST00000343619	NBR1	chr17	41338267	ENST00000542611
ATP6V0A1	chr17	40659645	ENST00000343619	NBR1	chr17	41338267	ENST00000589872
ATP6V0A1	chr17	40659645	ENST00000537728	NBR1	chr17	41338267	ENST00000341165
ATP6V0A1	chr17	40659645	ENST00000537728	NBR1	chr17	41338267	ENST00000542611
ATP6V0A1	chr17	40659645	ENST00000537728	NBR1	chr17	41338267	ENST00000589872
ATP6V0A1	chr17	40659645	ENST00000544137	NBR1	chr17	41338267	ENST00000341165
ATP6V0A1	chr17	40659645	ENST00000544137	NBR1	chr17	41338267	ENST00000542611
ATP6V0A1	chr17	40659645	ENST00000544137	NBR1	chr17	41338267	ENST00000589872

Top

Related Drugs to ATP6V0A1-NBR1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ATP6V0A1-NBR1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)