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Fusion Protein:SH3GL1-ANKRD24

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SH3GL1-ANKRD24
	FusionPDB ID: 81447
	FusionGDB2.0 ID: 81447
		Hgene	Tgene
	Gene symbol	SH3GL1	ANKRD24
	Gene ID	6455	170961
	Gene name	SH3 domain containing GRB2 like 1, endophilin A2	ankyrin repeat domain 24
	Synonyms	CNSA1\|EEN\|SH3D2B\|SH3P8	-
	Cytomap	19p13.3	19p13.3
	Type of gene	protein-coding	protein-coding
	Description	endophilin-A2EEN fusion partner of MLLSH3 domain protein 2BSH3 domain-containing GRB2-like protein 1SH3-containing Grb-2-like 1 proteinSH3-domain GRB2-like 1endophilin-2extra 11-19 leukemia fusionextra eleven-nineteen leukemia fusion gene protein	ankyrin repeat domain-containing protein 24
	Modification date	20200313	20200313
	UniProtAcc	Q99961 Main function of 5'-partner protein: FUNCTION: Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}.	Q8TF21 Main function of 5'-partner protein:
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000269886, ENST00000417295, ENST00000598564,	ENST00000595096, ENST00000262970, ENST00000318934, ENST00000600132,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	18 X 9 X 12=1944	7 X 7 X 7=343
	# samples	22	9
	** MAII score	log2(22/1944*10)=-3.14345279008112 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/343*10)=-1.93021166984314 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: SH3GL1 [Title/Abstract] AND ANKRD24 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: SH3GL1 [Title/Abstract] AND ANKRD24 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SH3GL1(4400321)-ANKRD24(4219588), # samples:3
Anticipated loss of major functional domain due to fusion event.	SH3GL1-ANKRD24 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SH3GL1-ANKRD24 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:4400321/chr19:4219588)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across SH3GL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ANKRD24 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000269886	SH3GL1	chr19	4400321	-	ENST00000600132	ANKRD24	chr19	4219588	+	971	224	179	661	160
ENST00000269886	SH3GL1	chr19	4400321	-	ENST00000318934	ANKRD24	chr19	4219588	+	971	224	179	661	160
ENST00000269886	SH3GL1	chr19	4400321	-	ENST00000262970	ANKRD24	chr19	4219588	+	662	224	179	661	161
ENST00000598564	SH3GL1	chr19	4400321	-	ENST00000600132	ANKRD24	chr19	4219588	+	842	95	50	532	160
ENST00000598564	SH3GL1	chr19	4400321	-	ENST00000318934	ANKRD24	chr19	4219588	+	842	95	50	532	160
ENST00000598564	SH3GL1	chr19	4400321	-	ENST00000262970	ANKRD24	chr19	4219588	+	533	95	50	532	161
ENST00000417295	SH3GL1	chr19	4400321	-	ENST00000600132	ANKRD24	chr19	4219588	+	949	202	157	639	160
ENST00000417295	SH3GL1	chr19	4400321	-	ENST00000318934	ANKRD24	chr19	4219588	+	949	202	157	639	160
ENST00000417295	SH3GL1	chr19	4400321	-	ENST00000262970	ANKRD24	chr19	4219588	+	640	202	157	639	161
ENST00000269886	SH3GL1	chr19	4400320	-	ENST00000600132	ANKRD24	chr19	4219587	+	971	224	179	661	160
ENST00000269886	SH3GL1	chr19	4400320	-	ENST00000318934	ANKRD24	chr19	4219587	+	971	224	179	661	160
ENST00000269886	SH3GL1	chr19	4400320	-	ENST00000262970	ANKRD24	chr19	4219587	+	662	224	179	661	161
ENST00000598564	SH3GL1	chr19	4400320	-	ENST00000600132	ANKRD24	chr19	4219587	+	842	95	50	532	160
ENST00000598564	SH3GL1	chr19	4400320	-	ENST00000318934	ANKRD24	chr19	4219587	+	842	95	50	532	160
ENST00000598564	SH3GL1	chr19	4400320	-	ENST00000262970	ANKRD24	chr19	4219587	+	533	95	50	532	161
ENST00000417295	SH3GL1	chr19	4400320	-	ENST00000600132	ANKRD24	chr19	4219587	+	949	202	157	639	160
ENST00000417295	SH3GL1	chr19	4400320	-	ENST00000318934	ANKRD24	chr19	4219587	+	949	202	157	639	160
ENST00000417295	SH3GL1	chr19	4400320	-	ENST00000262970	ANKRD24	chr19	4219587	+	640	202	157	639	161

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000269886	ENST00000600132	SH3GL1	chr19	4400321	-	ANKRD24	chr19	4219588	+	0.002250857	0.99774915
ENST00000269886	ENST00000318934	SH3GL1	chr19	4400321	-	ANKRD24	chr19	4219588	+	0.002250857	0.99774915
ENST00000269886	ENST00000262970	SH3GL1	chr19	4400321	-	ANKRD24	chr19	4219588	+	0.001031808	0.99896824
ENST00000598564	ENST00000600132	SH3GL1	chr19	4400321	-	ANKRD24	chr19	4219588	+	0.002028682	0.99797136
ENST00000598564	ENST00000318934	SH3GL1	chr19	4400321	-	ANKRD24	chr19	4219588	+	0.002028682	0.99797136
ENST00000598564	ENST00000262970	SH3GL1	chr19	4400321	-	ANKRD24	chr19	4219588	+	0.000763948	0.9992361
ENST00000417295	ENST00000600132	SH3GL1	chr19	4400321	-	ANKRD24	chr19	4219588	+	0.00263677	0.99736327
ENST00000417295	ENST00000318934	SH3GL1	chr19	4400321	-	ANKRD24	chr19	4219588	+	0.00263677	0.99736327
ENST00000417295	ENST00000262970	SH3GL1	chr19	4400321	-	ANKRD24	chr19	4219588	+	0.001189157	0.9988109
ENST00000269886	ENST00000600132	SH3GL1	chr19	4400320	-	ANKRD24	chr19	4219587	+	0.002250857	0.99774915
ENST00000269886	ENST00000318934	SH3GL1	chr19	4400320	-	ANKRD24	chr19	4219587	+	0.002250857	0.99774915
ENST00000269886	ENST00000262970	SH3GL1	chr19	4400320	-	ANKRD24	chr19	4219587	+	0.001031808	0.99896824
ENST00000598564	ENST00000600132	SH3GL1	chr19	4400320	-	ANKRD24	chr19	4219587	+	0.002028682	0.99797136
ENST00000598564	ENST00000318934	SH3GL1	chr19	4400320	-	ANKRD24	chr19	4219587	+	0.002028682	0.99797136
ENST00000598564	ENST00000262970	SH3GL1	chr19	4400320	-	ANKRD24	chr19	4219587	+	0.000763948	0.9992361
ENST00000417295	ENST00000600132	SH3GL1	chr19	4400320	-	ANKRD24	chr19	4219587	+	0.00263677	0.99736327
ENST00000417295	ENST00000318934	SH3GL1	chr19	4400320	-	ANKRD24	chr19	4219587	+	0.00263677	0.99736327
ENST00000417295	ENST00000262970	SH3GL1	chr19	4400320	-	ANKRD24	chr19	4219587	+	0.001189157	0.9988109

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for SH3GL1-ANKRD24

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
SH3GL1	chr19	4400320	ANKRD24	chr19	4219587	202	14	SVAGLKKQFYKASQVQREALFMKSER
SH3GL1	chr19	4400320	ANKRD24	chr19	4219587	224	14	SVAGLKKQFYKASQVQREALFMKSER
SH3GL1	chr19	4400320	ANKRD24	chr19	4219587	95	14	SVAGLKKQFYKASQVQREALFMKSER
SH3GL1	chr19	4400321	ANKRD24	chr19	4219588	202	14	SVAGLKKQFYKASQVQREALFMKSER
SH3GL1	chr19	4400321	ANKRD24	chr19	4219588	224	14	SVAGLKKQFYKASQVQREALFMKSER
SH3GL1	chr19	4400321	ANKRD24	chr19	4219588	95	14	SVAGLKKQFYKASQVQREALFMKSER

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Potential FusionNeoAntigen Information of SH3GL1-ANKRD24 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

SH3GL1-ANKRD24_4400320_4219587.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B48:01	SQVQREAL	0.9984	0.5789	12	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B14:02	SQVQREAL	0.99	0.7886	12	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B14:01	SQVQREAL	0.99	0.7886	12	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B39:13	SQVQREAL	0.9503	0.944	12	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:01	SQVQREALF	0.9982	0.9127	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-A33:05	FYKASQVQR	0.971	0.5509	8	17
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-A33:01	FYKASQVQR	0.971	0.5509	8	17
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-A31:02	FYKASQVQR	0.9286	0.8356	8	17
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:25	SQVQREALF	0.874	0.9468	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-A31:06	FYKASQVQR	0.8609	0.6491	8	17
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B48:01	SQVQREALF	0.8513	0.6152	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B47:01	SQVQREALF	0.772	0.5025	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:03	SQVQREALF	0.7701	0.8452	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:18	SQVQREALF	0.62	0.7919	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B13:01	SQVQREALF	0.6084	0.9744	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-A31:02	QFYKASQVQR	0.9265	0.9148	7	17
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-A33:05	QFYKASQVQR	0.8957	0.7002	7	17
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-A33:01	QFYKASQVQR	0.8957	0.7002	7	17
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-A31:06	QFYKASQVQR	0.8873	0.8273	7	17
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B57:01	KASQVQREALF	0.9999	0.9811	10	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B58:02	KASQVQREALF	0.9998	0.9674	10	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B57:03	KASQVQREALF	0.9996	0.9863	10	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B58:01	KASQVQREALF	0.9993	0.9617	10	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-A74:11	KQFYKASQVQR	0.9812	0.9309	6	17
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-A74:03	KQFYKASQVQR	0.9812	0.9309	6	17
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-A74:09	KQFYKASQVQR	0.9812	0.9309	6	17
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-A31:02	KQFYKASQVQR	0.9523	0.9274	6	17
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-A31:06	KQFYKASQVQR	0.9237	0.7955	6	17
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B14:03	SQVQREAL	0.9719	0.7955	12	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:07	SQVQREALF	0.9803	0.7559	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:04	SQVQREALF	0.9685	0.9406	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-A31:01	FYKASQVQR	0.9456	0.807	8	17
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:05	SQVQREALF	0.7511	0.8988	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-A31:01	QFYKASQVQR	0.9582	0.9069	7	17
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-A31:01	KQFYKASQVQR	0.9822	0.9228	6	17
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B39:02	SQVQREAL	0.9921	0.9376	12	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:73	SQVQREAL	0.9709	0.903	12	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:135	SQVQREALF	0.9984	0.9179	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:33	SQVQREALF	0.9982	0.9127	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:125	SQVQREALF	0.9982	0.9127	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:34	SQVQREALF	0.9982	0.9127	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:27	SQVQREALF	0.9982	0.9296	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:50	SQVQREALF	0.9968	0.9078	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:24	SQVQREALF	0.9957	0.8981	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:12	SQVQREALF	0.9808	0.914	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:35	SQVQREALF	0.9797	0.9152	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:53	SQVQREALF	0.8998	0.9091	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:39	SQVQREALF	0.8776	0.8838	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:73	SQVQREALF	0.856	0.8982	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:54	SQVQREALF	0.84	0.8909	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:68	SQVQREALF	0.8399	0.7179	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:20	SQVQREALF	0.7361	0.9345	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B35:28	SQVQREALF	0.7089	0.9404	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:30	SQVQREALF	0.7037	0.9293	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B40:21	SQVQREALF	0.6191	0.5186	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B48:02	SQVQREALF	0.6032	0.9302	12	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B15:24	ASQVQREALF	0.9964	0.8808	11	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B57:04	KASQVQREALF	0.9999	0.7133	10	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B57:10	KASQVQREALF	0.9999	0.9811	10	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B58:06	KASQVQREALF	0.9998	0.9509	10	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-B57:02	KASQVQREALF	0.9993	0.8353	10	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	HLA-A74:01	KQFYKASQVQR	0.9812	0.9309	6	17

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Potential FusionNeoAntigen Information of SH3GL1-ANKRD24 in HLA II

SH3GL1-ANKRD24_4400320_4219587.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0405	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0405	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0405	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0407	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0407	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0407	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0409	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0409	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0409	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0417	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0417	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0417	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0424	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0424	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0424	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0429	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0429	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0429	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0430	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0430	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0430	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0445	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0445	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0445	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0448	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0448	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0448	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0457	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0457	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0457	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0469	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0469	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0469	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0474	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0474	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0477	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0477	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0477	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0480	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0480	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0480	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0483	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0483	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0483	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0484	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0484	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0484	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0486	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0486	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0486	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0487	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0487	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0487	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0489	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0489	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0489	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0829	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0829	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0829	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0840	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0840	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0901	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0901	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0901	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0902	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0902	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0902	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0902	GLKKQFYKASQVQRE	3	18
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0903	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0903	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0903	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0903	GLKKQFYKASQVQRE	3	18
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0904	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0904	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0904	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0905	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0905	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0907	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0907	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0907	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0908	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0908	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0908	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0908	GLKKQFYKASQVQRE	3	18
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0909	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0909	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-0909	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1341	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1386	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1386	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1402	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1402	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1413	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1413	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1419	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1419	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1424	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1424	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1441	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1441	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1446	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1446	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1447	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1447	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1451	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1451	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1489	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1489	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1494	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1494	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1498	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB1-1498	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0101	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0101	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0101	GLKKQFYKASQVQRE	3	18
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0102	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0102	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0102	GLKKQFYKASQVQRE	3	18
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0103	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0103	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0104	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0104	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0104	GLKKQFYKASQVQRE	3	18
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0105	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0105	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0105	GLKKQFYKASQVQRE	3	18
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0108N	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0108N	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0108N	GLKKQFYKASQVQRE	3	18
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0111	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0111	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0112	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0112	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0112	KQFYKASQVQREALF	6	21
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0112	GLKKQFYKASQVQRE	3	18
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0113	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0113	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0113	GLKKQFYKASQVQRE	3	18
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0114	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0114	KKQFYKASQVQREAL	5	20
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0114	GLKKQFYKASQVQRE	3	18
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0203	LKKQFYKASQVQREA	4	19
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	224	DRB5-0203	KKQFYKASQVQREAL	5	20

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Fusion breakpoint peptide structures of SH3GL1-ANKRD24

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
4519	KQFYKASQVQREAL	SH3GL1	ANKRD24	chr19	4400320	chr19	4219587	224

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of SH3GL1-ANKRD24

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	4519	KQFYKASQVQREAL	-6.86709	-6.98049
HLA-B14:02	3BVN	4519	KQFYKASQVQREAL	-5.21559	-6.25089
HLA-B52:01	3W39	4519	KQFYKASQVQREAL	-5.51066	-6.54596
HLA-B52:01	3W39	4519	KQFYKASQVQREAL	-4.90699	-5.02039
HLA-A24:02	5HGA	4519	KQFYKASQVQREAL	-9.01457	-9.12797
HLA-A24:02	5HGA	4519	KQFYKASQVQREAL	-5.62253	-6.65783
HLA-B27:05	6PYJ	4519	KQFYKASQVQREAL	-4.55985	-4.67325
HLA-B44:05	3DX8	4519	KQFYKASQVQREAL	-4.47172	-4.58512
HLA-B44:05	3DX8	4519	KQFYKASQVQREAL	-3.76673	-4.80203

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Vaccine Design for the FusionNeoAntigens of SH3GL1-ANKRD24

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	10	21	KASQVQREALF	GCGAGCCAGGTGCAGCGTGAGGCCCTGTTCATG
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	11	21	ASQVQREALF	AGCCAGGTGCAGCGTGAGGCCCTGTTCATG
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	12	20	SQVQREAL	CAGGTGCAGCGTGAGGCCCTGTTC
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	12	21	SQVQREALF	CAGGTGCAGCGTGAGGCCCTGTTCATG
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	6	17	KQFYKASQVQR	CAGTTCTACAAGGCGAGCCAGGTGCAGCGTGAG
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	7	17	QFYKASQVQR	TTCTACAAGGCGAGCCAGGTGCAGCGTGAG
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	8	17	FYKASQVQR	TACAAGGCGAGCCAGGTGCAGCGTGAG

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	3	18	GLKKQFYKASQVQRE	CTGAAGAAGCAGTTCTACAAGGCGAGCCAGGTGCAGCGTGAGGCC
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	4	19	LKKQFYKASQVQREA	AAGAAGCAGTTCTACAAGGCGAGCCAGGTGCAGCGTGAGGCCCTG
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	5	20	KKQFYKASQVQREAL	AAGCAGTTCTACAAGGCGAGCCAGGTGCAGCGTGAGGCCCTGTTC
SH3GL1-ANKRD24	chr19	4400320	chr19	4219587	6	21	KQFYKASQVQREALF	CAGTTCTACAAGGCGAGCCAGGTGCAGCGTGAGGCCCTGTTCATG

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Information of the samples that have these potential fusion neoantigens of SH3GL1-ANKRD24

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
BRCA	SH3GL1-ANKRD24	chr19	4400320	ENST00000269886	chr19	4219587	ENST00000262970	TCGA-GM-A2DC

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Potential target of CAR-T therapy development for SH3GL1-ANKRD24

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to SH3GL1-ANKRD24

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to SH3GL1-ANKRD24

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)