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Fusion Protein:SLC22A15-ANO1

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SLC22A15-ANO1
	FusionPDB ID: 82447
	FusionGDB2.0 ID: 82447
		Hgene	Tgene
	Gene symbol	SLC22A15	ANO1
	Gene ID	55356	55107
	Gene name	solute carrier family 22 member 15	anoctamin 1
	Synonyms	FLIPT1\|PRO34686	DOG1\|ORAOV2\|TAOS2\|TMEM16A
	Cytomap	1p13.1	11q13.3
	Type of gene	protein-coding	protein-coding
	Description	solute carrier family 22 member 15flipt 1fly-like putative organic ion transporter 1fly-like putative transporter 1solute carrier family 22 (organic cation transporter), member 15trans-like protein	anoctamin-1Ca2+-activated Cl- channelanoctamin 1, calcium activated chloride channelcalcium activated chloride channeldiscovered on gastrointestinal stromal tumors protein 1oral cancer overexpressed 2transmembrane protein 16A (eight membrane-spannin
	Modification date	20200313	20200313
	UniProtAcc	.	Q9NW15 Main function of 5'-partner protein: FUNCTION: Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. {ECO:0000269\|PubMed:20056604, ECO:0000269\|PubMed:22946059}.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000481127, ENST00000369503, ENST00000369502,	ENST00000316296, ENST00000355303, ENST00000398543, ENST00000530676, ENST00000531349, ENST00000538023, ENST00000525494,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 3 X 4=48	19 X 28 X 10=5320
	# samples	4	36
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(36/5320*10)=-3.88535743405888 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: SLC22A15 [Title/Abstract] AND ANO1 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: SLC22A15 [Title/Abstract] AND ANO1 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SLC22A15(116580009)-ANO1(69995816), # samples:3
Anticipated loss of major functional domain due to fusion event.	SLC22A15-ANO1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SLC22A15-ANO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ANO1	GO:0006812	cation transport	22946059

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:116580009/chr11:69995816)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across SLC22A15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ANO1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000369503	SLC22A15	chr1	116580009	+	ENST00000355303	ANO1	chr11	69995816	+	4528	1301	67	3003	978
ENST00000369503	SLC22A15	chr1	116580009	+	ENST00000398543	ANO1	chr11	69995816	+	4437	1301	67	2913	948
ENST00000369503	SLC22A15	chr1	116580009	+	ENST00000538023	ANO1	chr11	69995816	+	4527	1301	67	3003	978
ENST00000369503	SLC22A15	chr1	116580009	+	ENST00000316296	ANO1	chr11	69995816	+	2140	1301	67	2055	662
ENST00000369503	SLC22A15	chr1	116580009	+	ENST00000530676	ANO1	chr11	69995816	+	3191	1301	67	2913	948
ENST00000369503	SLC22A15	chr1	116580009	+	ENST00000531349	ANO1	chr11	69995816	+	4174	1301	67	2925	952

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000369503	ENST00000355303	SLC22A15	chr1	116580009	+	ANO1	chr11	69995816	+	0.000408847	0.9995912
ENST00000369503	ENST00000398543	SLC22A15	chr1	116580009	+	ANO1	chr11	69995816	+	0.000434633	0.9995653
ENST00000369503	ENST00000538023	SLC22A15	chr1	116580009	+	ANO1	chr11	69995816	+	0.00040976	0.9995902
ENST00000369503	ENST00000316296	SLC22A15	chr1	116580009	+	ANO1	chr11	69995816	+	0.001993845	0.99800617
ENST00000369503	ENST00000530676	SLC22A15	chr1	116580009	+	ANO1	chr11	69995816	+	0.001297109	0.9987029
ENST00000369503	ENST00000531349	SLC22A15	chr1	116580009	+	ANO1	chr11	69995816	+	0.000652865	0.99934715

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for SLC22A15-ANO1

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
SLC22A15	chr1	116580009	ANO1	chr11	69995816	1301	406	LCLGGLACLIVMFLPEKKAATFMEHW

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Potential FusionNeoAntigen Information of SLC22A15-ANO1 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

SLC22A15-ANO1_116580009_69995816.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B08:09	FLPEKKAA	0.9982	0.9483	12	20
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B35:08	FLPEKKAATF	0.9572	0.8934	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B35:05	FLPEKKAATF	0.9441	0.7168	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B35:01	FLPEKKAATF	0.9063	0.9134	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B35:02	FLPEKKAATF	0.697	0.9613	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B35:04	FLPEKKAATF	0.697	0.9613	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B82:01	FLPEKKAATF	0.6672	0.6445	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B35:08	MFLPEKKAATF	0.9956	0.9404	11	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-A24:14	MFLPEKKAATF	0.9903	0.5862	11	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-A02:07	FLPEKKAAT	0.4495	0.8404	12	21
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B42:02	FLPEKKAATF	0.9935	0.9031	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-C01:17	FLPEKKAATF	0.9884	0.9604	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-C01:30	FLPEKKAATF	0.9651	0.9643	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B35:12	FLPEKKAATF	0.697	0.9613	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-C01:17	FLPEKKAATFM	0.9983	0.9666	12	23
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-C01:30	FLPEKKAATFM	0.996	0.9675	12	23
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-A02:07	FLPEKKAATFM	0.9568	0.7896	12	23
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B15:08	FLPEKKAATF	0.9996	0.9136	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-C01:03	FLPEKKAATF	0.9962	0.9742	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-C01:02	FLPEKKAATF	0.9886	0.9583	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B35:11	FLPEKKAATF	0.9816	0.9434	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B08:12	FLPEKKAATF	0.9512	0.9537	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B35:17	FLPEKKAATF	0.9432	0.8376	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B35:30	FLPEKKAATF	0.9432	0.8376	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B35:77	FLPEKKAATF	0.9063	0.9134	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B35:23	FLPEKKAATF	0.8976	0.9159	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B35:24	FLPEKKAATF	0.8271	0.8854	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B35:09	FLPEKKAATF	0.697	0.9613	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B82:02	FLPEKKAATF	0.6672	0.6445	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B53:02	FLPEKKAATF	0.6472	0.7026	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-B51:06	FLPEKKAATF	0.6311	0.7098	12	22
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-C01:03	FLPEKKAATFM	0.9995	0.9802	12	23
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	HLA-C01:02	FLPEKKAATFM	0.9982	0.965	12	23

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Potential FusionNeoAntigen Information of SLC22A15-ANO1 in HLA II

SLC22A15-ANO1_116580009_69995816.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	DRB1-1127	IVMFLPEKKAATFME	9	24
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	DRB1-1172	IVMFLPEKKAATFME	9	24
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	DRB1-1180	IVMFLPEKKAATFME	9	24
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	DRB1-1181	IVMFLPEKKAATFME	9	24
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	DRB1-1187	IVMFLPEKKAATFME	9	24
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	DRB1-1193	IVMFLPEKKAATFME	9	24
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	DRB1-1326	IVMFLPEKKAATFME	9	24
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	DRB1-1337	IVMFLPEKKAATFME	9	24
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	DRB1-1385	IVMFLPEKKAATFME	9	24
SLC22A15-ANO1	chr1	116580009	chr11	69995816	1301	DRB1-1427	IVMFLPEKKAATFME	9	24

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Fusion breakpoint peptide structures of SLC22A15-ANO1

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
88	ACLIVMFLPEKKAA	SLC22A15	ANO1	chr1	116580009	chr11	69995816	1301

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of SLC22A15-ANO1

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	88	ACLIVMFLPEKKAA	-7.9962	-8.1096
HLA-B14:02	3BVN	88	ACLIVMFLPEKKAA	-5.70842	-6.74372
HLA-B52:01	3W39	88	ACLIVMFLPEKKAA	-6.83737	-6.95077
HLA-B52:01	3W39	88	ACLIVMFLPEKKAA	-4.4836	-5.5189
HLA-A11:01	4UQ2	88	ACLIVMFLPEKKAA	-10.0067	-10.1201
HLA-A11:01	4UQ2	88	ACLIVMFLPEKKAA	-9.03915	-10.0745
HLA-A24:02	5HGA	88	ACLIVMFLPEKKAA	-6.56204	-6.67544
HLA-A24:02	5HGA	88	ACLIVMFLPEKKAA	-5.42271	-6.45801
HLA-B44:05	3DX8	88	ACLIVMFLPEKKAA	-7.85648	-8.89178
HLA-B44:05	3DX8	88	ACLIVMFLPEKKAA	-5.3978	-5.5112
HLA-A02:01	6TDR	88	ACLIVMFLPEKKAA	-3.37154	-4.40684

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Vaccine Design for the FusionNeoAntigens of SLC22A15-ANO1

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
SLC22A15-ANO1	chr1	116580009	chr11	69995816	11	22	MFLPEKKAATF	AGAAAGCTGCCACCTTCATGGAGCACTGGAAGC
SLC22A15-ANO1	chr1	116580009	chr11	69995816	12	20	FLPEKKAA	AAGCTGCCACCTTCATGGAGCACT
SLC22A15-ANO1	chr1	116580009	chr11	69995816	12	21	FLPEKKAAT	AAGCTGCCACCTTCATGGAGCACTGGA
SLC22A15-ANO1	chr1	116580009	chr11	69995816	12	22	FLPEKKAATF	AAGCTGCCACCTTCATGGAGCACTGGAAGC
SLC22A15-ANO1	chr1	116580009	chr11	69995816	12	23	FLPEKKAATFM	AAGCTGCCACCTTCATGGAGCACTGGAAGCGGA

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
SLC22A15-ANO1	chr1	116580009	chr11	69995816	9	24	IVMFLPEKKAATFME	CAGAAAAGAAAGCTGCCACCTTCATGGAGCACTGGAAGCGGAAAC

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Information of the samples that have these potential fusion neoantigens of SLC22A15-ANO1

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
BRCA	SLC22A15-ANO1	chr1	116580009	ENST00000369503	chr11	69995816	ENST00000316296	TCGA-A8-A0A6-01A

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Potential target of CAR-T therapy development for SLC22A15-ANO1

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC22A15

chr1:116580009

chr11:69995816

ENST00000369503

111_131

390

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr11:69995816

ENST00000369503

141_161

390

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr11:69995816

ENST00000369503

165_187

390

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr11:69995816

ENST00000369503

201_221

390

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr11:69995816

ENST00000369503

226_246

390

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr11:69995816

ENST00000369503

22_42

390

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr11:69995816

ENST00000369503

303_323

390

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr11:69995816

ENST00000369503

338_358

390

548.0

Transmembrane

Helical

Hgene

SLC22A15

chr1:116580009

chr11:69995816

ENST00000369503

368_388

390

548.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000316296

407_427

643.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000316296

520_540

643.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000316296

569_589

643.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000316296

608_628

643.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000316296

658_678

643.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000316296

726_746

643.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000316296

747_767

643.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000316296

785_805

643.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000316296

893_913

643.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000355303

520_540

987.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000355303

569_589

987.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000355303

608_628

987.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000355303

658_678

987.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000355303

726_746

987.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000355303

747_767

987.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000355303

785_805

987.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000355303

893_913

987.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000398543

334_354

841.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000398543

407_427

841.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000398543

520_540

841.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000398543

569_589

841.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000398543

608_628

841.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000398543

658_678

841.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000398543

726_746

841.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000398543

747_767

841.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000398543

785_805

841.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000398543

893_913

841.0

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000530676

334_354

819.3333333333334

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000530676

407_427

819.3333333333334

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000530676

520_540

819.3333333333334

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000530676

569_589

819.3333333333334

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000530676

608_628

819.3333333333334

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000530676

658_678

819.3333333333334

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000530676

726_746

819.3333333333334

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000530676

747_767

819.3333333333334

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000530676

785_805

819.3333333333334

Transmembrane

Helical

Tgene

ANO1

chr1:116580009

chr11:69995816

ENST00000530676

893_913

819.3333333333334

Transmembrane

Helical

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

Top

Related Drugs to SLC22A15-ANO1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to SLC22A15-ANO1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)