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Fusion Protein:SLC25A26-RBMS3

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SLC25A26-RBMS3
	FusionPDB ID: 82631
	FusionGDB2.0 ID: 82631
		Hgene	Tgene
	Gene symbol	SLC25A26	RBMS3
	Gene ID	115286	27303
	Gene name	solute carrier family 25 member 26	RNA binding motif single stranded interacting protein 3
	Synonyms	COXPD28\|SAMC	-
	Cytomap	3p14.1	3p24.1
	Type of gene	protein-coding	protein-coding
	Description	S-adenosylmethionine mitochondrial carrier proteinmitochondrial S-adenosylmethionine transportersolute carrier family 25 (S-adenosylmethionine carrier), member 26solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 26	RNA-binding motif, single-stranded-interacting protein 3RNA binding motif, single stranded interacting proteinRNA-binding protein
	Modification date	20200326	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000484768, ENST00000536651, ENST00000336733, ENST00000354883, ENST00000413054,	ENST00000273139, ENST00000383766, ENST00000383767, ENST00000396583, ENST00000434693, ENST00000445033, ENST00000452462, ENST00000456853, ENST00000473799,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	11 X 8 X 6=528	10 X 11 X 5=550
	# samples	11	11
	** MAII score	log2(11/528*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/550*10)=-2.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: SLC25A26 [Title/Abstract] AND RBMS3 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: SLC25A26 [Title/Abstract] AND RBMS3 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SLC25A26(66313803)-RBMS3(29476237), # samples:1
Anticipated loss of major functional domain due to fusion event.	SLC25A26-RBMS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SLC25A26-RBMS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:66313803/chr3:29476237)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across SLC25A26 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RBMS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000354883	SLC25A26	chr3	66313803	+	ENST00000434693	RBMS3	chr3	29476237	+	8946	1181	728	2416	562
ENST00000354883	SLC25A26	chr3	66313803	+	ENST00000396583	RBMS3	chr3	29476237	+	8944	1181	728	2410	560
ENST00000354883	SLC25A26	chr3	66313803	+	ENST00000383767	RBMS3	chr3	29476237	+	2634	1181	728	2419	563
ENST00000354883	SLC25A26	chr3	66313803	+	ENST00000445033	RBMS3	chr3	29476237	+	1915	1181	728	1900	390
ENST00000354883	SLC25A26	chr3	66313803	+	ENST00000273139	RBMS3	chr3	29476237	+	2474	1181	728	2368	546
ENST00000354883	SLC25A26	chr3	66313803	+	ENST00000383766	RBMS3	chr3	29476237	+	3633	1181	728	2365	545
ENST00000354883	SLC25A26	chr3	66313803	+	ENST00000452462	RBMS3	chr3	29476237	+	2523	1181	728	2371	547
ENST00000354883	SLC25A26	chr3	66313803	+	ENST00000456853	RBMS3	chr3	29476237	+	2434	1181	728	2407	559
ENST00000336733	SLC25A26	chr3	66313803	+	ENST00000434693	RBMS3	chr3	29476237	+	8144	379	73	1614	513
ENST00000336733	SLC25A26	chr3	66313803	+	ENST00000396583	RBMS3	chr3	29476237	+	8142	379	73	1608	511
ENST00000336733	SLC25A26	chr3	66313803	+	ENST00000383767	RBMS3	chr3	29476237	+	1832	379	73	1617	514
ENST00000336733	SLC25A26	chr3	66313803	+	ENST00000445033	RBMS3	chr3	29476237	+	1113	379	73	1098	341
ENST00000336733	SLC25A26	chr3	66313803	+	ENST00000273139	RBMS3	chr3	29476237	+	1672	379	73	1566	497
ENST00000336733	SLC25A26	chr3	66313803	+	ENST00000383766	RBMS3	chr3	29476237	+	2831	379	73	1563	496
ENST00000336733	SLC25A26	chr3	66313803	+	ENST00000452462	RBMS3	chr3	29476237	+	1721	379	73	1569	498
ENST00000336733	SLC25A26	chr3	66313803	+	ENST00000456853	RBMS3	chr3	29476237	+	1632	379	73	1605	510
ENST00000413054	SLC25A26	chr3	66313803	+	ENST00000434693	RBMS3	chr3	29476237	+	8028	263	41	1498	485
ENST00000413054	SLC25A26	chr3	66313803	+	ENST00000396583	RBMS3	chr3	29476237	+	8026	263	41	1492	483
ENST00000413054	SLC25A26	chr3	66313803	+	ENST00000383767	RBMS3	chr3	29476237	+	1716	263	41	1501	486
ENST00000413054	SLC25A26	chr3	66313803	+	ENST00000445033	RBMS3	chr3	29476237	+	997	263	41	982	313
ENST00000413054	SLC25A26	chr3	66313803	+	ENST00000273139	RBMS3	chr3	29476237	+	1556	263	41	1450	469
ENST00000413054	SLC25A26	chr3	66313803	+	ENST00000383766	RBMS3	chr3	29476237	+	2715	263	41	1447	468
ENST00000413054	SLC25A26	chr3	66313803	+	ENST00000452462	RBMS3	chr3	29476237	+	1605	263	41	1453	470
ENST00000413054	SLC25A26	chr3	66313803	+	ENST00000456853	RBMS3	chr3	29476237	+	1516	263	41	1489	482

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000354883	ENST00000434693	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	0.000147384	0.99985254
ENST00000354883	ENST00000396583	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	0.000140052	0.9998599
ENST00000354883	ENST00000383767	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	0.001258896	0.9987411
ENST00000354883	ENST00000445033	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	0.001505362	0.9984946
ENST00000354883	ENST00000273139	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	0.001342789	0.9986572
ENST00000354883	ENST00000383766	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	0.000610107	0.9993899
ENST00000354883	ENST00000452462	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	0.001355889	0.9986442
ENST00000354883	ENST00000456853	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	0.001865028	0.998135
ENST00000336733	ENST00000434693	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	6.67E-05	0.99993324
ENST00000336733	ENST00000396583	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	5.45E-05	0.9999455
ENST00000336733	ENST00000383767	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	0.000621034	0.9993789
ENST00000336733	ENST00000445033	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	0.001148794	0.9988512
ENST00000336733	ENST00000273139	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	0.000555353	0.99944466
ENST00000336733	ENST00000383766	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	0.000188234	0.9998118
ENST00000336733	ENST00000452462	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	0.000602445	0.9993975
ENST00000336733	ENST00000456853	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	0.000830697	0.99916935
ENST00000413054	ENST00000434693	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	6.59E-05	0.9999342
ENST00000413054	ENST00000396583	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	5.40E-05	0.999946
ENST00000413054	ENST00000383767	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	0.000645919	0.99935406
ENST00000413054	ENST00000445033	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	0.001462366	0.99853766
ENST00000413054	ENST00000273139	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	0.000637111	0.9993629
ENST00000413054	ENST00000383766	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	0.000191703	0.9998084
ENST00000413054	ENST00000452462	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	0.000648353	0.9993517
ENST00000413054	ENST00000456853	SLC25A26	chr3	66313803	+	RBMS3	chr3	29476237	+	0.001007306	0.99899274

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for SLC25A26-RBMS3

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
SLC25A26	chr3	66313803	RBMS3	chr3	29476237	1181	151	GLYRGYKSTVLREQSYAPAPHPMAPP
SLC25A26	chr3	66313803	RBMS3	chr3	29476237	1181	151	GLYRGYKSTVLRESYAPAPHPMAPPS
SLC25A26	chr3	66313803	RBMS3	chr3	29476237	263	74	GLYRGYKSTVLREQSYAPAPHPMAPP
SLC25A26	chr3	66313803	RBMS3	chr3	29476237	263	74	GLYRGYKSTVLRESYAPAPHPMAPPS
SLC25A26	chr3	66313803	RBMS3	chr3	29476237	379	102	GLYRGYKSTVLREQSYAPAPHPMAPP
SLC25A26	chr3	66313803	RBMS3	chr3	29476237	379	102	GLYRGYKSTVLRESYAPAPHPMAPPS

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Potential FusionNeoAntigen Information of SLC25A26-RBMS3 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

SLC25A26-RBMS3_66313803_29476237.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B41:01	RESYAPAP	0.9891	0.5811	11	19
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B41:01	REQSYAPA	0.9871	0.7197	11	19
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B50:01	REQSYAPA	0.7797	0.8528	11	19
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:25	STVLREQSY	0.9979	0.8764	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B57:01	KSTVLRESY	0.9978	0.8905	6	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:17	KSTVLRESY	0.996	0.7857	6	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B58:02	KSTVLRESY	0.9951	0.828	6	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B58:01	KSTVLRESY	0.9921	0.723	6	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:02	STVLREQSY	0.9917	0.8935	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B45:01	REQSYAPAP	0.9914	0.9189	11	20
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:01	STVLREQSY	0.9851	0.8726	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:17	STVLREQSY	0.9841	0.818	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B50:02	REQSYAPAP	0.9809	0.7126	11	20
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:16	STVLREQSY	0.8637	0.6299	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B41:01	REQSYAPAP	0.5838	0.8573	11	20
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B50:01	REQSYAPAP	0.3956	0.9029	11	20
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-A26:02	ESYAPAPHPM	0.9951	0.5707	12	22
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B45:01	RESYAPAPHP	0.979	0.9202	11	21
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B50:02	RESYAPAPHP	0.9735	0.666	11	21
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B41:01	RESYAPAPHP	0.9561	0.6825	11	21
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B50:01	RESYAPAPHP	0.9302	0.743	11	21
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:03	YKSTVLRESY	0.9041	0.6553	5	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B50:01	REQSYAPAPHP	0.9919	0.9302	11	22
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B40:06	REQSYAPAP	0.9937	0.8325	11	20
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:21	STVLREQSY	0.9918	0.8581	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B73:01	LREQSYAPA	0.9712	0.9032	10	19
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:07	STVLREQSY	0.9653	0.5702	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:05	STVLREQSY	0.9642	0.8167	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:31	STVLREQSY	0.9064	0.8186	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-C15:04	KSTVLRESY	0.8929	0.8017	6	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B73:01	LRESYAPAP	0.8205	0.7183	10	19
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-C15:04	STVLREQSY	0.7786	0.7594	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-C03:14	STVLREQSY	0.2991	0.9252	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-C12:04	STVLREQSY	0.1236	0.9745	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-C12:12	STVLREQSY	0.0572	0.8076	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B40:06	RESYAPAPHP	0.9898	0.8049	11	21
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B40:06	REQSYAPAPHP	0.9996	0.9265	11	22
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B50:04	REQSYAPA	0.7797	0.8528	11	19
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B50:05	REQSYAPA	0.7797	0.8528	11	19
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B57:10	KSTVLRESY	0.9978	0.8905	6	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:39	STVLREQSY	0.9976	0.8188	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B58:06	KSTVLRESY	0.9944	0.6602	6	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B57:04	KSTVLRESY	0.9943	0.6004	6	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B35:11	STVLREQSY	0.9896	0.8582	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:27	STVLREQSY	0.9857	0.878	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:33	STVLREQSY	0.9851	0.8726	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:34	STVLREQSY	0.9851	0.8726	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:125	STVLREQSY	0.9851	0.8726	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:135	STVLREQSY	0.9844	0.8935	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:50	STVLREQSY	0.9794	0.8353	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:11	STVLREQSY	0.9677	0.8294	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:20	STVLREQSY	0.9674	0.8598	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:08	STVLREQSY	0.966	0.8217	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:35	STVLREQSY	0.9603	0.837	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B58:06	STVLREQSY	0.9544	0.7233	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B57:04	STVLREQSY	0.9507	0.5799	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B35:43	STVLREQSY	0.9487	0.8233	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B35:28	STVLREQSY	0.9443	0.8748	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:12	STVLREQSY	0.9331	0.8293	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B35:20	STVLREQSY	0.9124	0.882	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-C15:09	KSTVLRESY	0.8929	0.8017	6	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-A25:01	STVLREQSY	0.8429	0.5879	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-C03:02	STVLREQSY	0.7967	0.9374	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-C15:09	STVLREQSY	0.7786	0.7594	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-C16:01	KSTVLRESY	0.5399	0.9557	6	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B50:05	REQSYAPAP	0.3956	0.9029	11	20
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B50:04	REQSYAPAP	0.3956	0.9029	11	20
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-C16:04	STVLREQSY	0.3635	0.9218	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-C16:01	STVLREQSY	0.2903	0.9402	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-C16:02	KSTVLRESY	0.2804	0.9781	6	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-C12:02	STVLREQSY	0.2472	0.8996	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-C16:02	STVLREQSY	0.2388	0.9756	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-C12:03	STVLREQSY	0.0724	0.892	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-C02:02	STVLREQSY	0.0452	0.9196	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-C02:10	STVLREQSY	0.0452	0.9196	7	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B57:04	KSTVLREQSY	0.997	0.5879	6	16
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B50:04	RESYAPAPHP	0.9302	0.743	11	21
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B50:05	RESYAPAPHP	0.9302	0.743	11	21
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:54	YKSTVLRESY	0.89	0.8563	5	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B48:02	YKSTVLRESY	0.8658	0.8491	5	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B15:68	YKSTVLRESY	0.8305	0.5661	5	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B40:04	RESYAPAPHPM	0.9991	0.7807	11	22
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B50:04	REQSYAPAPHP	0.9919	0.9302	11	22
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	HLA-B50:05	REQSYAPAPHP	0.9919	0.9302	11	22

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Potential FusionNeoAntigen Information of SLC25A26-RBMS3 in HLA II

SLC25A26-RBMS3_66313803_29476237.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-0434	REQSYAPAPHPMAPP	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-0434	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-0434	LRESYAPAPHPMAPP	10	25
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-0466	REQSYAPAPHPMAPP	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-0466	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-0466	LRESYAPAPHPMAPP	10	25
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-0802	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-0809	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-0813	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-0821	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-0824	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-0824	LRESYAPAPHPMAPP	10	25
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-0902	REQSYAPAPHPMAPP	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-0902	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-0902	LRESYAPAPHPMAPP	10	25
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-0908	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1130	REQSYAPAPHPMAPP	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1130	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1130	LRESYAPAPHPMAPP	10	25
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1137	REQSYAPAPHPMAPP	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1137	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1137	LRESYAPAPHPMAPP	10	25
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1153	REQSYAPAPHPMAPP	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1153	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1153	LRESYAPAPHPMAPP	10	25
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1169	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1193	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1307	REQSYAPAPHPMAPP	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1307	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1307	LRESYAPAPHPMAPP	10	25
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1326	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1337	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1347	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1347	LRESYAPAPHPMAPP	10	25
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1360	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1385	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1402	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1409	REQSYAPAPHPMAPP	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1409	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1409	LRESYAPAPHPMAPP	10	25
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1414	REQSYAPAPHPMAPP	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1414	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1414	LRESYAPAPHPMAPP	10	25
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1422	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1425	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1427	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1436	REQSYAPAPHPMAPP	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1436	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1436	LRESYAPAPHPMAPP	10	25
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1441	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1444	REQSYAPAPHPMAPP	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1444	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1444	LRESYAPAPHPMAPP	10	25
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1446	REQSYAPAPHPMAPP	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1446	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1446	LRESYAPAPHPMAPP	10	25
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1451	REQSYAPAPHPMAPP	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1451	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1451	LRESYAPAPHPMAPP	10	25
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1494	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1502	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1502	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1508	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1508	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1511	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1511	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1514	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1514	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1515	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1515	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1519	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1519	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1526	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1526	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1527	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1527	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1529	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1529	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1530	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1530	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1531	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1531	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1534	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1534	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1538	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1538	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1539	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1539	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1544	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1544	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1547	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1547	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1602	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1602	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1604	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1604	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1605	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1605	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1607	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1607	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1609	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1609	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1610	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1610	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1611	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1611	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1614	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1616	GLYRGYKSTVLREQS	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB1-1616	GLYRGYKSTVLRESY	0	15
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB3-0215	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB3-0217	REQSYAPAPHPMAPP	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB3-0217	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB3-0217	LRESYAPAPHPMAPP	10	25
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB5-0112	REQSYAPAPHPMAPP	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB5-0112	RESYAPAPHPMAPPS	11	26
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	379	DRB5-0112	LRESYAPAPHPMAPP	10	25

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Fusion breakpoint peptide structures of SLC25A26-RBMS3

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
4615	KSTVLREQSYAPAP	SLC25A26	RBMS3	chr3	66313803	chr3	29476237	379

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
4616	KSTVLRESYAPAPH	SLC25A26	RBMS3	chr3	66313803	chr3	29476237	379

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of SLC25A26-RBMS3

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	4615	KSTVLREQSYAPAP	-7.9962	-8.1096
HLA-B14:02	3BVN	4615	KSTVLREQSYAPAP	-5.70842	-6.74372
HLA-B52:01	3W39	4615	KSTVLREQSYAPAP	-6.83737	-6.95077
HLA-B52:01	3W39	4615	KSTVLREQSYAPAP	-4.4836	-5.5189
HLA-A11:01	4UQ2	4615	KSTVLREQSYAPAP	-10.0067	-10.1201
HLA-A11:01	4UQ2	4615	KSTVLREQSYAPAP	-9.03915	-10.0745
HLA-A24:02	5HGA	4615	KSTVLREQSYAPAP	-6.56204	-6.67544
HLA-A24:02	5HGA	4615	KSTVLREQSYAPAP	-5.42271	-6.45801
HLA-B44:05	3DX8	4615	KSTVLREQSYAPAP	-7.85648	-8.89178
HLA-B44:05	3DX8	4615	KSTVLREQSYAPAP	-5.3978	-5.5112
HLA-A02:01	6TDR	4615	KSTVLREQSYAPAP	-3.37154	-4.40684
HLA-B14:02	3BVN	4616	KSTVLRESYAPAPH	-8.55667	-8.74867
HLA-B14:02	3BVN	4616	KSTVLRESYAPAPH	-3.49457	-4.25557
HLA-B52:01	3W39	4616	KSTVLRESYAPAPH	-7.26725	-7.45925
HLA-B52:01	3W39	4616	KSTVLRESYAPAPH	-4.01461	-4.77561
HLA-A24:02	5HGA	4616	KSTVLRESYAPAPH	-7.65911	-8.42011
HLA-A24:02	5HGA	4616	KSTVLRESYAPAPH	-7.10204	-7.29404
HLA-B44:05	3DX8	4616	KSTVLRESYAPAPH	-7.5556	-8.3166
HLA-B44:05	3DX8	4616	KSTVLRESYAPAPH	-2.76159	-2.95359

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Vaccine Design for the FusionNeoAntigens of SLC25A26-RBMS3

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	10	19	LREQSYAPA	TTAAGAGAGCAGTCCTATGCACCAGCT
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	10	19	LRESYAPAP	TTAAGAGAGTCCTATGCACCAGCTCCC
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	11	19	REQSYAPA	AGAGAGCAGTCCTATGCACCAGCT
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	11	19	RESYAPAP	AGAGAGTCCTATGCACCAGCTCCC
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	11	20	REQSYAPAP	AGAGAGCAGTCCTATGCACCAGCTCCC
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	11	21	RESYAPAPHP	AGAGAGTCCTATGCACCAGCTCCCCACCCC
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	11	22	REQSYAPAPHP	AGAGAGCAGTCCTATGCACCAGCTCCCCACCCC
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	11	22	RESYAPAPHPM	AGAGAGTCCTATGCACCAGCTCCCCACCCCATG
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	12	22	ESYAPAPHPM	GAGTCCTATGCACCAGCTCCCCACCCCATG
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	5	15	YKSTVLRESY	TATAAAAGCACAGTTTTAAGAGAGTCCTAT
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	6	15	KSTVLRESY	AAAAGCACAGTTTTAAGAGAGTCCTAT
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	6	16	KSTVLREQSY	AAAAGCACAGTTTTAAGAGAGCAGTCCTAT
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	7	16	STVLREQSY	AGCACAGTTTTAAGAGAGCAGTCCTAT

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	0	15	GLYRGYKSTVLREQS	GGGTTGTATCGAGGCTATAAAAGCACAGTTTTAAGAGAGCAGTCC
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	0	15	GLYRGYKSTVLRESY	GGGTTGTATCGAGGCTATAAAAGCACAGTTTTAAGAGAGTCCTAT
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	10	25	LRESYAPAPHPMAPP	TTAAGAGAGTCCTATGCACCAGCTCCCCACCCCATGGCTCCTCCC
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	11	26	REQSYAPAPHPMAPP	AGAGAGCAGTCCTATGCACCAGCTCCCCACCCCATGGCTCCTCCC
SLC25A26-RBMS3	chr3	66313803	chr3	29476237	11	26	RESYAPAPHPMAPPS	AGAGAGTCCTATGCACCAGCTCCCCACCCCATGGCTCCTCCCAGC

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Information of the samples that have these potential fusion neoantigens of SLC25A26-RBMS3

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
STAD	SLC25A26-RBMS3	chr3	66313803	ENST00000336733	chr3	29476237	ENST00000273139	TCGA-BR-8364-01A
STAD	SLC25A26-RBMS3	chr3	66313803	ENST00000336733	chr3	29476237	ENST00000383766	TCGA-BR-8364-01A

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Potential target of CAR-T therapy development for SLC25A26-RBMS3

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC25A26

chr3:66313803

chr3:29476237

ENST00000336733

5_25

187.0

Transmembrane

Helical%3B Name%3D1

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to SLC25A26-RBMS3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to SLC25A26-RBMS3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)