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Fusion Protein:SLC34A2-ROS1 |
Fusion Gene and Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: SLC34A2-ROS1 | FusionPDB ID: 82926 | FusionGDB2.0 ID: 82926 | Hgene | Tgene | Gene symbol | SLC34A2 | ROS1 | Gene ID | 10568 | 6098 |
Gene name | solute carrier family 34 member 2 | ROS proto-oncogene 1, receptor tyrosine kinase | |
Synonyms | NAPI-3B|NAPI-IIb|NPTIIb|PULAM | MCF3|ROS|c-ros-1 | |
Cytomap | 4p15.2 | 6q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | sodium-dependent phosphate transport protein 2Bsodium/phosphate cotransporter 2Bsolute carrier family 34 (sodium phosphate), member 2solute carrier family 34 (type II sodium/phosphate cotransporter), member 2type II sodium-dependent phosphate transpor | proto-oncogene tyrosine-protein kinase ROSROS proto-oncogene 1 , receptor tyrosine kinasec-ros oncogene 1 , receptor tyrosine kinaseproto-oncogene c-Ros-1transmembrane tyrosine-specific protein kinasev-ros avian UR2 sarcoma virus oncogene homolog 1 | |
Modification date | 20200313 | 20200314 | |
UniProtAcc | O95436 Main function of 5'-partner protein: FUNCTION: May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli. | P08922 Main function of 5'-partner protein: FUNCTION: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. {ECO:0000269|PubMed:11094073, ECO:0000269|PubMed:16885344}. | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000382051, ENST00000503434, ENST00000504570, ENST00000510033, | ENST00000368507, ENST00000368508, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 8 X 10 X 6=480 | 18 X 20 X 5=1800 |
# samples | 15 | 20 | |
** MAII score | log2(15/480*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/1800*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Fusion gene context | PubMed: SLC34A2 [Title/Abstract] AND ROS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Fusion neoantigen context | PubMed: SLC34A2 [Title/Abstract] AND ROS1 [Title/Abstract] AND neoantigen [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | SLC34A2(25665952)-ROS1(117650611), # samples:4 SLC34A2(25665952)-ROS1(117645580), # samples:4 | ||
Anticipated loss of major functional domain due to fusion event. | SLC34A2-ROS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SLC34A2-ROS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SLC34A2-ROS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SLC34A2-ROS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SLC34A2-ROS1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. SLC34A2-ROS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. SLC34A2-ROS1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. SLC34A2-ROS1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. SLC34A2-ROS1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. SLC34A2-ROS1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SLC34A2 | GO:0006817 | phosphate ion transport | 10329428|10610722|12488042 |
Hgene | SLC34A2 | GO:0030643 | cellular phosphate ion homeostasis | 10610722 |
Tgene | ROS1 | GO:0001558 | regulation of cell growth | 16885344 |
Tgene | ROS1 | GO:0006468 | protein phosphorylation | 16885344 |
Tgene | ROS1 | GO:0032006 | regulation of TOR signaling | 16885344 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:25665952/chr6:117650611) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Amino Acid Sequences |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000504570 | SLC34A2 | chr4 | 25665952 | + | ENST00000368508 | ROS1 | chr6 | 117650609 | - | 2436 | 448 | 27 | 2243 | 738 |
ENST00000504570 | SLC34A2 | chr4 | 25665952 | + | ENST00000368507 | ROS1 | chr6 | 117650609 | - | 2436 | 448 | 27 | 2243 | 738 |
ENST00000382051 | SLC34A2 | chr4 | 25665952 | + | ENST00000368508 | ROS1 | chr6 | 117650609 | - | 2417 | 429 | 5 | 2224 | 739 |
ENST00000382051 | SLC34A2 | chr4 | 25665952 | + | ENST00000368507 | ROS1 | chr6 | 117650609 | - | 2417 | 429 | 5 | 2224 | 739 |
ENST00000503434 | SLC34A2 | chr4 | 25665952 | + | ENST00000368508 | ROS1 | chr6 | 117650609 | - | 2468 | 480 | 56 | 2275 | 739 |
ENST00000503434 | SLC34A2 | chr4 | 25665952 | + | ENST00000368507 | ROS1 | chr6 | 117650609 | - | 2468 | 480 | 56 | 2275 | 739 |
ENST00000382051 | SLC34A2 | chr4 | 25678323 | + | ENST00000368508 | ROS1 | chr6 | 117650608 | - | 5543 | 3555 | 3719 | 5350 | 543 |
ENST00000382051 | SLC34A2 | chr4 | 25678323 | + | ENST00000368507 | ROS1 | chr6 | 117650608 | - | 5543 | 3555 | 3719 | 5350 | 543 |
ENST00000382051 | SLC34A2 | chr4 | 25678324 | + | ENST00000368508 | ROS1 | chr6 | 117645578 | - | 5233 | 3554 | 5 | 1672 | 555 |
ENST00000382051 | SLC34A2 | chr4 | 25678324 | + | ENST00000368507 | ROS1 | chr6 | 117645578 | - | 5233 | 3554 | 5 | 1672 | 555 |
ENST00000382051 | SLC34A2 | chr4 | 25678324 | + | ENST00000368508 | ROS1 | chr6 | 117650609 | - | 5542 | 3554 | 5 | 1672 | 555 |
ENST00000382051 | SLC34A2 | chr4 | 25678324 | + | ENST00000368507 | ROS1 | chr6 | 117650609 | - | 5542 | 3554 | 5 | 1672 | 555 |
ENST00000382051 | SLC34A2 | chr4 | 25678323 | + | ENST00000368508 | ROS1 | chr6 | 117650608 | - | 5543 | 3555 | 3719 | 5350 | 543 |
ENST00000382051 | SLC34A2 | chr4 | 25678323 | + | ENST00000368507 | ROS1 | chr6 | 117650608 | - | 5543 | 3555 | 3719 | 5350 | 543 |
ENST00000382051 | SLC34A2 | chr4 | 25678323 | + | ENST00000368508 | ROS1 | chr6 | 117645577 | - | 5234 | 3555 | 5 | 1555 | 516 |
ENST00000382051 | SLC34A2 | chr4 | 25678323 | + | ENST00000368507 | ROS1 | chr6 | 117645577 | - | 5234 | 3555 | 5 | 1555 | 516 |
ENST00000382051 | SLC34A2 | chr4 | 25678324 | + | ENST00000368508 | ROS1 | chr6 | 117650610 | - | 5542 | 3554 | 5 | 1672 | 555 |
ENST00000382051 | SLC34A2 | chr4 | 25678324 | + | ENST00000368507 | ROS1 | chr6 | 117650610 | - | 5542 | 3554 | 5 | 1672 | 555 |
ENST00000504570 | SLC34A2 | chr4 | 25665952 | + | ENST00000368508 | ROS1 | chr6 | 117650611 | - | 2436 | 448 | 27 | 2243 | 738 |
ENST00000504570 | SLC34A2 | chr4 | 25665952 | + | ENST00000368507 | ROS1 | chr6 | 117650611 | - | 2436 | 448 | 27 | 2243 | 738 |
ENST00000382051 | SLC34A2 | chr4 | 25665952 | + | ENST00000368508 | ROS1 | chr6 | 117650611 | - | 2417 | 429 | 5 | 2224 | 739 |
ENST00000382051 | SLC34A2 | chr4 | 25665952 | + | ENST00000368507 | ROS1 | chr6 | 117650611 | - | 2417 | 429 | 5 | 2224 | 739 |
ENST00000503434 | SLC34A2 | chr4 | 25665952 | + | ENST00000368508 | ROS1 | chr6 | 117650611 | - | 2468 | 480 | 56 | 2275 | 739 |
ENST00000503434 | SLC34A2 | chr4 | 25665952 | + | ENST00000368507 | ROS1 | chr6 | 117650611 | - | 2468 | 480 | 56 | 2275 | 739 |
ENST00000504570 | SLC34A2 | chr4 | 25665952 | + | ENST00000368508 | ROS1 | chr6 | 117645580 | - | 2127 | 448 | 27 | 1934 | 635 |
ENST00000504570 | SLC34A2 | chr4 | 25665952 | + | ENST00000368507 | ROS1 | chr6 | 117645580 | - | 2127 | 448 | 27 | 1934 | 635 |
ENST00000382051 | SLC34A2 | chr4 | 25665952 | + | ENST00000368508 | ROS1 | chr6 | 117645580 | - | 2108 | 429 | 5 | 1915 | 636 |
ENST00000382051 | SLC34A2 | chr4 | 25665952 | + | ENST00000368507 | ROS1 | chr6 | 117645580 | - | 2108 | 429 | 5 | 1915 | 636 |
ENST00000503434 | SLC34A2 | chr4 | 25665952 | + | ENST00000368508 | ROS1 | chr6 | 117645580 | - | 2159 | 480 | 56 | 1966 | 636 |
ENST00000503434 | SLC34A2 | chr4 | 25665952 | + | ENST00000368507 | ROS1 | chr6 | 117645580 | - | 2159 | 480 | 56 | 1966 | 636 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000382051 | ENST00000368508 | SLC34A2 | chr4 | 25678324 | + | ROS1 | chr6 | 117645578 | - | 0.002851092 | 0.99714893 |
ENST00000382051 | ENST00000368507 | SLC34A2 | chr4 | 25678324 | + | ROS1 | chr6 | 117645578 | - | 0.002851092 | 0.99714893 |
ENST00000382051 | ENST00000368508 | SLC34A2 | chr4 | 25678324 | + | ROS1 | chr6 | 117650609 | - | 0.001479008 | 0.99852103 |
ENST00000382051 | ENST00000368507 | SLC34A2 | chr4 | 25678324 | + | ROS1 | chr6 | 117650609 | - | 0.001479008 | 0.99852103 |
ENST00000382051 | ENST00000368508 | SLC34A2 | chr4 | 25678323 | + | ROS1 | chr6 | 117650608 | - | 0.001461032 | 0.998539 |
ENST00000382051 | ENST00000368507 | SLC34A2 | chr4 | 25678323 | + | ROS1 | chr6 | 117650608 | - | 0.001461032 | 0.998539 |
ENST00000382051 | ENST00000368508 | SLC34A2 | chr4 | 25678323 | + | ROS1 | chr6 | 117645577 | - | 0.00199012 | 0.99800986 |
ENST00000382051 | ENST00000368507 | SLC34A2 | chr4 | 25678323 | + | ROS1 | chr6 | 117645577 | - | 0.00199012 | 0.99800986 |
ENST00000382051 | ENST00000368508 | SLC34A2 | chr4 | 25678324 | + | ROS1 | chr6 | 117650610 | - | 0.001479008 | 0.99852103 |
ENST00000382051 | ENST00000368507 | SLC34A2 | chr4 | 25678324 | + | ROS1 | chr6 | 117650610 | - | 0.001479008 | 0.99852103 |
ENST00000504570 | ENST00000368508 | SLC34A2 | chr4 | 25665952 | + | ROS1 | chr6 | 117650611 | - | 0.000734107 | 0.99926585 |
ENST00000504570 | ENST00000368507 | SLC34A2 | chr4 | 25665952 | + | ROS1 | chr6 | 117650611 | - | 0.000734107 | 0.99926585 |
ENST00000382051 | ENST00000368508 | SLC34A2 | chr4 | 25665952 | + | ROS1 | chr6 | 117650611 | - | 0.000832633 | 0.99916744 |
ENST00000382051 | ENST00000368507 | SLC34A2 | chr4 | 25665952 | + | ROS1 | chr6 | 117650611 | - | 0.000832633 | 0.99916744 |
ENST00000503434 | ENST00000368508 | SLC34A2 | chr4 | 25665952 | + | ROS1 | chr6 | 117650611 | - | 0.000689765 | 0.99931026 |
ENST00000503434 | ENST00000368507 | SLC34A2 | chr4 | 25665952 | + | ROS1 | chr6 | 117650611 | - | 0.000689765 | 0.99931026 |
ENST00000504570 | ENST00000368508 | SLC34A2 | chr4 | 25665952 | + | ROS1 | chr6 | 117645580 | - | 0.0008013 | 0.99919873 |
ENST00000504570 | ENST00000368507 | SLC34A2 | chr4 | 25665952 | + | ROS1 | chr6 | 117645580 | - | 0.0008013 | 0.99919873 |
ENST00000382051 | ENST00000368508 | SLC34A2 | chr4 | 25665952 | + | ROS1 | chr6 | 117645580 | - | 0.001263778 | 0.9987362 |
ENST00000382051 | ENST00000368507 | SLC34A2 | chr4 | 25665952 | + | ROS1 | chr6 | 117645580 | - | 0.001263778 | 0.9987362 |
ENST00000503434 | ENST00000368508 | SLC34A2 | chr4 | 25665952 | + | ROS1 | chr6 | 117645580 | - | 0.000674601 | 0.9993254 |
ENST00000503434 | ENST00000368507 | SLC34A2 | chr4 | 25665952 | + | ROS1 | chr6 | 117645580 | - | 0.000674601 | 0.9993254 |
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Get the fusion protein sequences from here. |
Fusion protein sequence information is available in the fasta format. >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP |
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Fusion Protein Breakpoint Sequences for SLC34A2-ROS1 |
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Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Length(fusion protein) | BP in fusion protein | Peptide |
SLC34A2 | chr4 | 25665952 | ROS1 | chr6 | 117645580 | 429 | 141 | SLDILSSAFQLVGDDFWIPETSFILT |
SLC34A2 | chr4 | 25665952 | ROS1 | chr6 | 117645580 | 448 | 140 | SLDILSSAFQLVGDDFWIPETSFILT |
SLC34A2 | chr4 | 25665952 | ROS1 | chr6 | 117645580 | 480 | 141 | SLDILSSAFQLVGDDFWIPETSFILT |
SLC34A2 | chr4 | 25665952 | ROS1 | chr6 | 117650609 | 429 | 141 | SLDILSSAFQLVGAGVPNKPGIPKLL |
SLC34A2 | chr4 | 25665952 | ROS1 | chr6 | 117650609 | 448 | 140 | SLDILSSAFQLVGAGVPNKPGIPKLL |
SLC34A2 | chr4 | 25665952 | ROS1 | chr6 | 117650609 | 480 | 141 | SLDILSSAFQLVGAGVPNKPGIPKLL |
SLC34A2 | chr4 | 25665952 | ROS1 | chr6 | 117650611 | 429 | 141 | SLDILSSAFQLVGAGVPNKPGIPKLL |
SLC34A2 | chr4 | 25665952 | ROS1 | chr6 | 117650611 | 448 | 140 | SLDILSSAFQLVGAGVPNKPGIPKLL |
SLC34A2 | chr4 | 25665952 | ROS1 | chr6 | 117650611 | 480 | 141 | SLDILSSAFQLVGAGVPNKPGIPKLL |
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Potential FusionNeoAntigen Information of SLC34A2-ROS1 in HLA I |
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SLC34A2-ROS1_25665952_117645580.msa | |
SLC34A2-ROS1_25665952_117650609.msa |
![]() * We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5) |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA I | FusionNeoAntigen peptide | Binding score | Immunogenic score | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
SLC34A2-ROS1 | chr4 | 25665952 | chr6 | 117645580 | 429 | HLA-B57:01 | SAFQLVGDDFW | 0.9999 | 0.9694 | 6 | 17 |
SLC34A2-ROS1 | chr4 | 25665952 | chr6 | 117645580 | 429 | HLA-B58:01 | SAFQLVGDDFW | 0.9994 | 0.9272 | 6 | 17 |
SLC34A2-ROS1 | chr4 | 25665952 | chr6 | 117645580 | 429 | HLA-B57:03 | SAFQLVGDDFW | 0.9984 | 0.9797 | 6 | 17 |
SLC34A2-ROS1 | chr4 | 25665952 | chr6 | 117645580 | 429 | HLA-B15:24 | FQLVGDDFW | 0.8382 | 0.8496 | 8 | 17 |
SLC34A2-ROS1 | chr4 | 25665952 | chr6 | 117645580 | 429 | HLA-B57:10 | SAFQLVGDDFW | 0.9999 | 0.9694 | 6 | 17 |
SLC34A2-ROS1 | chr4 | 25665952 | chr6 | 117645580 | 429 | HLA-B57:04 | SAFQLVGDDFW | 0.9998 | 0.7591 | 6 | 17 |
SLC34A2-ROS1 | chr4 | 25665952 | chr6 | 117645580 | 429 | HLA-B57:02 | SAFQLVGDDFW | 0.9989 | 0.8885 | 6 | 17 |
SLC34A2-ROS1 | chr4 | 25665952 | chr6 | 117650609 | 429 | HLA-A11:03 | LVGAGVPNK | 0.9947 | 0.6796 | 10 | 19 |
SLC34A2-ROS1 | chr4 | 25665952 | chr6 | 117650609 | 429 | HLA-A11:04 | LVGAGVPNK | 0.9831 | 0.6861 | 10 | 19 |
SLC34A2-ROS1 | chr4 | 25665952 | chr6 | 117650609 | 429 | HLA-A03:12 | LVGAGVPNK | 0.9756 | 0.7533 | 10 | 19 |
SLC34A2-ROS1 | chr4 | 25665952 | chr6 | 117650609 | 429 | HLA-A03:25 | LVGAGVPNK | 0.9749 | 0.7237 | 10 | 19 |
SLC34A2-ROS1 | chr4 | 25665952 | chr6 | 117650609 | 429 | HLA-A11:01 | LVGAGVPNK | 0.9948 | 0.6441 | 10 | 19 |
SLC34A2-ROS1 | chr4 | 25665952 | chr6 | 117650609 | 429 | HLA-A03:01 | LVGAGVPNK | 0.9749 | 0.7237 | 10 | 19 |
SLC34A2-ROS1 | chr4 | 25665952 | chr6 | 117650609 | 429 | HLA-A11:02 | LVGAGVPNK | 0.9948 | 0.6441 | 10 | 19 |
SLC34A2-ROS1 | chr4 | 25665952 | chr6 | 117650609 | 429 | HLA-A03:02 | LVGAGVPNK | 0.9772 | 0.5991 | 10 | 19 |
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Potential FusionNeoAntigen Information of SLC34A2-ROS1 in HLA II |
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![]() * We used NetMHCIIpan v4.1 (%rank<0.5). |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA II | FusionNeoAntigen peptide | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
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Fusion breakpoint peptide structures of SLC34A2-ROS1 |
![]() * The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA. |
File name | BPseq | Hgene | Tgene | Hchr | Hbp | Tchr | Tbp | AAlen |
8384 | SAFQLVGAGVPNKP | SLC34A2 | ROS1 | chr4 | 25665952 | chr6 | 117650609 | 429 |
File name | BPseq | Hgene | Tgene | Hchr | Hbp | Tchr | Tbp | AAlen |
8385 | SAFQLVGDDFWIPE | SLC34A2 | ROS1 | chr4 | 25665952 | chr6 | 117645580 | 429 |
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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of SLC34A2-ROS1 |
![]() * We used Glide to predict the interaction between HLAs and neoantigens. |
HLA allele | PDB ID | File name | BPseq | Docking score | Glide score |
HLA-B14:02 | 3BVN | 8384 | SAFQLVGAGVPNKP | -7.15543 | -7.26883 |
HLA-B14:02 | 3BVN | 8384 | SAFQLVGAGVPNKP | -4.77435 | -5.80965 |
HLA-B52:01 | 3W39 | 8384 | SAFQLVGAGVPNKP | -6.80875 | -6.92215 |
HLA-B52:01 | 3W39 | 8384 | SAFQLVGAGVPNKP | -4.20386 | -5.23916 |
HLA-A11:01 | 4UQ2 | 8384 | SAFQLVGAGVPNKP | -7.5194 | -8.5547 |
HLA-A11:01 | 4UQ2 | 8384 | SAFQLVGAGVPNKP | -6.9601 | -7.0735 |
HLA-A24:02 | 5HGA | 8384 | SAFQLVGAGVPNKP | -7.52403 | -7.63743 |
HLA-A24:02 | 5HGA | 8384 | SAFQLVGAGVPNKP | -5.82433 | -6.85963 |
HLA-B27:05 | 6PYJ | 8384 | SAFQLVGAGVPNKP | -3.28285 | -4.31815 |
HLA-B44:05 | 3DX8 | 8384 | SAFQLVGAGVPNKP | -5.91172 | -6.94702 |
HLA-B44:05 | 3DX8 | 8384 | SAFQLVGAGVPNKP | -4.24346 | -4.35686 |
HLA-B14:02 | 3BVN | 8385 | SAFQLVGDDFWIPE | -7.15543 | -7.26883 |
HLA-B14:02 | 3BVN | 8385 | SAFQLVGDDFWIPE | -4.77435 | -5.80965 |
HLA-B52:01 | 3W39 | 8385 | SAFQLVGDDFWIPE | -6.80875 | -6.92215 |
HLA-B52:01 | 3W39 | 8385 | SAFQLVGDDFWIPE | -4.20386 | -5.23916 |
HLA-A11:01 | 4UQ2 | 8385 | SAFQLVGDDFWIPE | -7.5194 | -8.5547 |
HLA-A11:01 | 4UQ2 | 8385 | SAFQLVGDDFWIPE | -6.9601 | -7.0735 |
HLA-A24:02 | 5HGA | 8385 | SAFQLVGDDFWIPE | -7.52403 | -7.63743 |
HLA-A24:02 | 5HGA | 8385 | SAFQLVGDDFWIPE | -5.82433 | -6.85963 |
HLA-B27:05 | 6PYJ | 8385 | SAFQLVGDDFWIPE | -3.28285 | -4.31815 |
HLA-B44:05 | 3DX8 | 8385 | SAFQLVGDDFWIPE | -5.91172 | -6.94702 |
HLA-B44:05 | 3DX8 | 8385 | SAFQLVGDDFWIPE | -4.24346 | -4.35686 |
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Vaccine Design for the FusionNeoAntigens of SLC34A2-ROS1 |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide sequence | FusionNeoAntigen RNA sequence |
SLC34A2-ROS1 | chr4 | 25665952 | chr6 | 117645580 | 6 | 17 | SAFQLVGDDFW | GCGCCTTCCAGCTGGTTGGAGATGATTTTTGGA |
SLC34A2-ROS1 | chr4 | 25665952 | chr6 | 117645580 | 8 | 17 | FQLVGDDFW | TCCAGCTGGTTGGAGATGATTTTTGGA |
SLC34A2-ROS1 | chr4 | 25665952 | chr6 | 117650609 | 10 | 19 | LVGAGVPNK | TGGTTGGAGCTGGAGTCCCAAATAAAC |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide | FusionNEoAntigen RNA sequence |
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Information of the samples that have these potential fusion neoantigens of SLC34A2-ROS1 |
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Cancer type | Fusion gene | Hchr | Hbp | Henst | Tchr | Tbp | Tenst | Sample |
N/A | SLC34A2-ROS1 | chr4 | 25665952 | ENST00000382051 | chr6 | 117645580 | ENST00000368507 | EU236947 |
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Potential target of CAR-T therapy development for SLC34A2-ROS1 |
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![]() * Minus value of BPloci means that the break point is located before the CDS. |
- In-frame and retained 'Transmembrane'. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | SLC34A2 | chr4:25665952 | chr6:117645580 | ENST00000382051 | + | 4 | 13 | 101_121 | 126 | 691.0 | Transmembrane | Helical%3B Name%3DM1 |
Hgene | SLC34A2 | chr4:25665952 | chr6:117645580 | ENST00000503434 | + | 4 | 13 | 101_121 | 125 | 690.0 | Transmembrane | Helical%3B Name%3DM1 |
Hgene | SLC34A2 | chr4:25665952 | chr6:117645580 | ENST00000504570 | + | 4 | 13 | 101_121 | 125 | 690.0 | Transmembrane | Helical%3B Name%3DM1 |
Hgene | SLC34A2 | chr4:25665952 | chr6:117650611 | ENST00000382051 | + | 4 | 13 | 101_121 | 126 | 691.0 | Transmembrane | Helical%3B Name%3DM1 |
Hgene | SLC34A2 | chr4:25665952 | chr6:117650611 | ENST00000503434 | + | 4 | 13 | 101_121 | 125 | 690.0 | Transmembrane | Helical%3B Name%3DM1 |
Hgene | SLC34A2 | chr4:25665952 | chr6:117650611 | ENST00000504570 | + | 4 | 13 | 101_121 | 125 | 690.0 | Transmembrane | Helical%3B Name%3DM1 |
Tgene | ROS1 | chr4:25665952 | chr6:117645580 | ENST00000368508 | 32 | 43 | 1860_1882 | 0 | 2348.0 | Transmembrane | Helical | |
Tgene | ROS1 | chr4:25665952 | chr6:117650611 | ENST00000368508 | 30 | 43 | 1860_1882 | 0 | 2348.0 | Transmembrane | Helical | |
Tgene | ROS1 | chr4:25678323 | chr6:117645577 | ENST00000368508 | 32 | 43 | 1860_1882 | 0 | 2348.0 | Transmembrane | Helical | |
Tgene | ROS1 | chr4:25678323 | chr6:117650608 | ENST00000368508 | 30 | 43 | 1860_1882 | 0 | 2348.0 | Transmembrane | Helical | |
Tgene | ROS1 | chr4:25678324 | chr6:117645578 | ENST00000368508 | 32 | 43 | 1860_1882 | 0 | 2348.0 | Transmembrane | Helical | |
Tgene | ROS1 | chr4:25678324 | chr6:117650609 | ENST00000368508 | 30 | 43 | 1860_1882 | 0 | 2348.0 | Transmembrane | Helical | |
Tgene | ROS1 | chr4:25678324 | chr6:117650610 | ENST00000368508 | 30 | 43 | 1860_1882 | 0 | 2348.0 | Transmembrane | Helical |
![]() * We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image. |
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Related Drugs to SLC34A2-ROS1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to SLC34A2-ROS1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
SLC34A2 | ROS1 | Lung Adenocarcinoma | MyCancerGenome | |
SLC34A2 | ROS1 | Dedifferentiated Liposarcoma | MyCancerGenome | |
SLC34A2 | ROS1 | Breast Invasive Ductal Carcinoma | MyCancerGenome | |
SLC34A2 | ROS1 | Anaplastic Ganglioglioma | MyCancerGenome | |
SLC34A2 | ROS1 | Cancer Of Unknown Primary | MyCancerGenome |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SLC34A2 | C0155912 | Pulmonary Alveolar Microlithiasis | 4 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | SLC34A2 | C0007131 | Non-Small Cell Lung Carcinoma | 2 | CTD_human |
Hgene | SLC34A2 | C0013221 | Drug toxicity | 1 | CTD_human |
Hgene | SLC34A2 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
Tgene | ROS1 | C0007131 | Non-Small Cell Lung Carcinoma | 4 | CTD_human |
Tgene | ROS1 | C0017638 | Glioma | 1 | CTD_human |
Tgene | ROS1 | C0025202 | melanoma | 1 | CTD_human |
Tgene | ROS1 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CGI;CTD_human |
Tgene | ROS1 | C0259783 | mixed gliomas | 1 | CTD_human |
Tgene | ROS1 | C0555198 | Malignant Glioma | 1 | CTD_human |