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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:SLC34A2-ROS1

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SLC34A2-ROS1
FusionPDB ID: 82926
FusionGDB2.0 ID: 82926
HgeneTgene
Gene symbol

SLC34A2

ROS1

Gene ID

10568

6098

Gene namesolute carrier family 34 member 2ROS proto-oncogene 1, receptor tyrosine kinase
SynonymsNAPI-3B|NAPI-IIb|NPTIIb|PULAMMCF3|ROS|c-ros-1
Cytomap

4p15.2

6q22.1

Type of geneprotein-codingprotein-coding
Descriptionsodium-dependent phosphate transport protein 2Bsodium/phosphate cotransporter 2Bsolute carrier family 34 (sodium phosphate), member 2solute carrier family 34 (type II sodium/phosphate cotransporter), member 2type II sodium-dependent phosphate transporproto-oncogene tyrosine-protein kinase ROSROS proto-oncogene 1 , receptor tyrosine kinasec-ros oncogene 1 , receptor tyrosine kinaseproto-oncogene c-Ros-1transmembrane tyrosine-specific protein kinasev-ros avian UR2 sarcoma virus oncogene homolog 1
Modification date2020031320200314
UniProtAcc

O95436

Main function of 5'-partner protein: FUNCTION: May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.

P08922

Main function of 5'-partner protein: FUNCTION: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. {ECO:0000269|PubMed:11094073, ECO:0000269|PubMed:16885344}.
Ensembl transtripts involved in fusion geneENST idsENST00000382051, ENST00000503434, 
ENST00000504570, ENST00000510033, 
ENST00000368507, ENST00000368508, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 10 X 6=48018 X 20 X 5=1800
# samples 1520
** MAII scorelog2(15/480*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/1800*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: SLC34A2 [Title/Abstract] AND ROS1 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: SLC34A2 [Title/Abstract] AND ROS1 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SLC34A2(25665952)-ROS1(117650611), # samples:4
SLC34A2(25665952)-ROS1(117645580), # samples:4
Anticipated loss of major functional domain due to fusion event.SLC34A2-ROS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC34A2-ROS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC34A2-ROS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC34A2-ROS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC34A2-ROS1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
SLC34A2-ROS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SLC34A2-ROS1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SLC34A2-ROS1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
SLC34A2-ROS1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SLC34A2-ROS1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC34A2

GO:0006817

phosphate ion transport

10329428|10610722|12488042

HgeneSLC34A2

GO:0030643

cellular phosphate ion homeostasis

10610722

TgeneROS1

GO:0001558

regulation of cell growth

16885344

TgeneROS1

GO:0006468

protein phosphorylation

16885344

TgeneROS1

GO:0032006

regulation of TOR signaling

16885344



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:25665952/chr6:117650611)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across SLC34A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ROS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000504570SLC34A2chr425665952+ENST00000368508ROS1chr6117650609-2436448272243738
ENST00000504570SLC34A2chr425665952+ENST00000368507ROS1chr6117650609-2436448272243738
ENST00000382051SLC34A2chr425665952+ENST00000368508ROS1chr6117650609-241742952224739
ENST00000382051SLC34A2chr425665952+ENST00000368507ROS1chr6117650609-241742952224739
ENST00000503434SLC34A2chr425665952+ENST00000368508ROS1chr6117650609-2468480562275739
ENST00000503434SLC34A2chr425665952+ENST00000368507ROS1chr6117650609-2468480562275739
ENST00000382051SLC34A2chr425678323+ENST00000368508ROS1chr6117650608-5543355537195350543
ENST00000382051SLC34A2chr425678323+ENST00000368507ROS1chr6117650608-5543355537195350543
ENST00000382051SLC34A2chr425678324+ENST00000368508ROS1chr6117645578-5233355451672555
ENST00000382051SLC34A2chr425678324+ENST00000368507ROS1chr6117645578-5233355451672555
ENST00000382051SLC34A2chr425678324+ENST00000368508ROS1chr6117650609-5542355451672555
ENST00000382051SLC34A2chr425678324+ENST00000368507ROS1chr6117650609-5542355451672555
ENST00000382051SLC34A2chr425678323+ENST00000368508ROS1chr6117650608-5543355537195350543
ENST00000382051SLC34A2chr425678323+ENST00000368507ROS1chr6117650608-5543355537195350543
ENST00000382051SLC34A2chr425678323+ENST00000368508ROS1chr6117645577-5234355551555516
ENST00000382051SLC34A2chr425678323+ENST00000368507ROS1chr6117645577-5234355551555516
ENST00000382051SLC34A2chr425678324+ENST00000368508ROS1chr6117650610-5542355451672555
ENST00000382051SLC34A2chr425678324+ENST00000368507ROS1chr6117650610-5542355451672555
ENST00000504570SLC34A2chr425665952+ENST00000368508ROS1chr6117650611-2436448272243738
ENST00000504570SLC34A2chr425665952+ENST00000368507ROS1chr6117650611-2436448272243738
ENST00000382051SLC34A2chr425665952+ENST00000368508ROS1chr6117650611-241742952224739
ENST00000382051SLC34A2chr425665952+ENST00000368507ROS1chr6117650611-241742952224739
ENST00000503434SLC34A2chr425665952+ENST00000368508ROS1chr6117650611-2468480562275739
ENST00000503434SLC34A2chr425665952+ENST00000368507ROS1chr6117650611-2468480562275739
ENST00000504570SLC34A2chr425665952+ENST00000368508ROS1chr6117645580-2127448271934635
ENST00000504570SLC34A2chr425665952+ENST00000368507ROS1chr6117645580-2127448271934635
ENST00000382051SLC34A2chr425665952+ENST00000368508ROS1chr6117645580-210842951915636
ENST00000382051SLC34A2chr425665952+ENST00000368507ROS1chr6117645580-210842951915636
ENST00000503434SLC34A2chr425665952+ENST00000368508ROS1chr6117645580-2159480561966636
ENST00000503434SLC34A2chr425665952+ENST00000368507ROS1chr6117645580-2159480561966636

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000382051ENST00000368508SLC34A2chr425678324+ROS1chr6117645578-0.0028510920.99714893
ENST00000382051ENST00000368507SLC34A2chr425678324+ROS1chr6117645578-0.0028510920.99714893
ENST00000382051ENST00000368508SLC34A2chr425678324+ROS1chr6117650609-0.0014790080.99852103
ENST00000382051ENST00000368507SLC34A2chr425678324+ROS1chr6117650609-0.0014790080.99852103
ENST00000382051ENST00000368508SLC34A2chr425678323+ROS1chr6117650608-0.0014610320.998539
ENST00000382051ENST00000368507SLC34A2chr425678323+ROS1chr6117650608-0.0014610320.998539
ENST00000382051ENST00000368508SLC34A2chr425678323+ROS1chr6117645577-0.001990120.99800986
ENST00000382051ENST00000368507SLC34A2chr425678323+ROS1chr6117645577-0.001990120.99800986
ENST00000382051ENST00000368508SLC34A2chr425678324+ROS1chr6117650610-0.0014790080.99852103
ENST00000382051ENST00000368507SLC34A2chr425678324+ROS1chr6117650610-0.0014790080.99852103
ENST00000504570ENST00000368508SLC34A2chr425665952+ROS1chr6117650611-0.0007341070.99926585
ENST00000504570ENST00000368507SLC34A2chr425665952+ROS1chr6117650611-0.0007341070.99926585
ENST00000382051ENST00000368508SLC34A2chr425665952+ROS1chr6117650611-0.0008326330.99916744
ENST00000382051ENST00000368507SLC34A2chr425665952+ROS1chr6117650611-0.0008326330.99916744
ENST00000503434ENST00000368508SLC34A2chr425665952+ROS1chr6117650611-0.0006897650.99931026
ENST00000503434ENST00000368507SLC34A2chr425665952+ROS1chr6117650611-0.0006897650.99931026
ENST00000504570ENST00000368508SLC34A2chr425665952+ROS1chr6117645580-0.00080130.99919873
ENST00000504570ENST00000368507SLC34A2chr425665952+ROS1chr6117645580-0.00080130.99919873
ENST00000382051ENST00000368508SLC34A2chr425665952+ROS1chr6117645580-0.0012637780.9987362
ENST00000382051ENST00000368507SLC34A2chr425665952+ROS1chr6117645580-0.0012637780.9987362
ENST00000503434ENST00000368508SLC34A2chr425665952+ROS1chr6117645580-0.0006746010.9993254
ENST00000503434ENST00000368507SLC34A2chr425665952+ROS1chr6117645580-0.0006746010.9993254

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for SLC34A2-ROS1

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
SLC34A2chr425665952ROS1chr6117645580429141SLDILSSAFQLVGDDFWIPETSFILT
SLC34A2chr425665952ROS1chr6117645580448140SLDILSSAFQLVGDDFWIPETSFILT
SLC34A2chr425665952ROS1chr6117645580480141SLDILSSAFQLVGDDFWIPETSFILT
SLC34A2chr425665952ROS1chr6117650609429141SLDILSSAFQLVGAGVPNKPGIPKLL
SLC34A2chr425665952ROS1chr6117650609448140SLDILSSAFQLVGAGVPNKPGIPKLL
SLC34A2chr425665952ROS1chr6117650609480141SLDILSSAFQLVGAGVPNKPGIPKLL
SLC34A2chr425665952ROS1chr6117650611429141SLDILSSAFQLVGAGVPNKPGIPKLL
SLC34A2chr425665952ROS1chr6117650611448140SLDILSSAFQLVGAGVPNKPGIPKLL
SLC34A2chr425665952ROS1chr6117650611480141SLDILSSAFQLVGAGVPNKPGIPKLL

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Potential FusionNeoAntigen Information of SLC34A2-ROS1 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
SLC34A2-ROS1_25665952_117645580.msa
SLC34A2-ROS1_25665952_117650609.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
SLC34A2-ROS1chr425665952chr6117645580429HLA-B57:01SAFQLVGDDFW0.99990.9694617
SLC34A2-ROS1chr425665952chr6117645580429HLA-B58:01SAFQLVGDDFW0.99940.9272617
SLC34A2-ROS1chr425665952chr6117645580429HLA-B57:03SAFQLVGDDFW0.99840.9797617
SLC34A2-ROS1chr425665952chr6117645580429HLA-B15:24FQLVGDDFW0.83820.8496817
SLC34A2-ROS1chr425665952chr6117645580429HLA-B57:10SAFQLVGDDFW0.99990.9694617
SLC34A2-ROS1chr425665952chr6117645580429HLA-B57:04SAFQLVGDDFW0.99980.7591617
SLC34A2-ROS1chr425665952chr6117645580429HLA-B57:02SAFQLVGDDFW0.99890.8885617
SLC34A2-ROS1chr425665952chr6117650609429HLA-A11:03LVGAGVPNK0.99470.67961019
SLC34A2-ROS1chr425665952chr6117650609429HLA-A11:04LVGAGVPNK0.98310.68611019
SLC34A2-ROS1chr425665952chr6117650609429HLA-A03:12LVGAGVPNK0.97560.75331019
SLC34A2-ROS1chr425665952chr6117650609429HLA-A03:25LVGAGVPNK0.97490.72371019
SLC34A2-ROS1chr425665952chr6117650609429HLA-A11:01LVGAGVPNK0.99480.64411019
SLC34A2-ROS1chr425665952chr6117650609429HLA-A03:01LVGAGVPNK0.97490.72371019
SLC34A2-ROS1chr425665952chr6117650609429HLA-A11:02LVGAGVPNK0.99480.64411019
SLC34A2-ROS1chr425665952chr6117650609429HLA-A03:02LVGAGVPNK0.97720.59911019

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Potential FusionNeoAntigen Information of SLC34A2-ROS1 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of SLC34A2-ROS1

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
8384SAFQLVGAGVPNKPSLC34A2ROS1chr425665952chr6117650609429
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
8385SAFQLVGDDFWIPESLC34A2ROS1chr425665952chr6117645580429

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of SLC34A2-ROS1

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN8384SAFQLVGAGVPNKP-7.15543-7.26883
HLA-B14:023BVN8384SAFQLVGAGVPNKP-4.77435-5.80965
HLA-B52:013W398384SAFQLVGAGVPNKP-6.80875-6.92215
HLA-B52:013W398384SAFQLVGAGVPNKP-4.20386-5.23916
HLA-A11:014UQ28384SAFQLVGAGVPNKP-7.5194-8.5547
HLA-A11:014UQ28384SAFQLVGAGVPNKP-6.9601-7.0735
HLA-A24:025HGA8384SAFQLVGAGVPNKP-7.52403-7.63743
HLA-A24:025HGA8384SAFQLVGAGVPNKP-5.82433-6.85963
HLA-B27:056PYJ8384SAFQLVGAGVPNKP-3.28285-4.31815
HLA-B44:053DX88384SAFQLVGAGVPNKP-5.91172-6.94702
HLA-B44:053DX88384SAFQLVGAGVPNKP-4.24346-4.35686
HLA-B14:023BVN8385SAFQLVGDDFWIPE-7.15543-7.26883
HLA-B14:023BVN8385SAFQLVGDDFWIPE-4.77435-5.80965
HLA-B52:013W398385SAFQLVGDDFWIPE-6.80875-6.92215
HLA-B52:013W398385SAFQLVGDDFWIPE-4.20386-5.23916
HLA-A11:014UQ28385SAFQLVGDDFWIPE-7.5194-8.5547
HLA-A11:014UQ28385SAFQLVGDDFWIPE-6.9601-7.0735
HLA-A24:025HGA8385SAFQLVGDDFWIPE-7.52403-7.63743
HLA-A24:025HGA8385SAFQLVGDDFWIPE-5.82433-6.85963
HLA-B27:056PYJ8385SAFQLVGDDFWIPE-3.28285-4.31815
HLA-B44:053DX88385SAFQLVGDDFWIPE-5.91172-6.94702
HLA-B44:053DX88385SAFQLVGDDFWIPE-4.24346-4.35686

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Vaccine Design for the FusionNeoAntigens of SLC34A2-ROS1

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
SLC34A2-ROS1chr425665952chr6117645580617SAFQLVGDDFWGCGCCTTCCAGCTGGTTGGAGATGATTTTTGGA
SLC34A2-ROS1chr425665952chr6117645580817FQLVGDDFWTCCAGCTGGTTGGAGATGATTTTTGGA
SLC34A2-ROS1chr425665952chr61176506091019LVGAGVPNKTGGTTGGAGCTGGAGTCCCAAATAAAC

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of SLC34A2-ROS1

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
N/ASLC34A2-ROS1chr425665952ENST00000382051chr6117645580ENST00000368507EU236947

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Potential target of CAR-T therapy development for SLC34A2-ROS1

check button Predicted 3D structure. We used RoseTTAFold.
442_SLC34A2-ROS1_t000_.e2e.pdb


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC34A2chr4:25665952chr6:117645580ENST00000382051+413101_121126691.0TransmembraneHelical%3B Name%3DM1
HgeneSLC34A2chr4:25665952chr6:117645580ENST00000503434+413101_121125690.0TransmembraneHelical%3B Name%3DM1
HgeneSLC34A2chr4:25665952chr6:117645580ENST00000504570+413101_121125690.0TransmembraneHelical%3B Name%3DM1
HgeneSLC34A2chr4:25665952chr6:117650611ENST00000382051+413101_121126691.0TransmembraneHelical%3B Name%3DM1
HgeneSLC34A2chr4:25665952chr6:117650611ENST00000503434+413101_121125690.0TransmembraneHelical%3B Name%3DM1
HgeneSLC34A2chr4:25665952chr6:117650611ENST00000504570+413101_121125690.0TransmembraneHelical%3B Name%3DM1
TgeneROS1chr4:25665952chr6:117645580ENST0000036850832431860_188202348.0TransmembraneHelical
TgeneROS1chr4:25665952chr6:117650611ENST0000036850830431860_188202348.0TransmembraneHelical
TgeneROS1chr4:25678323chr6:117645577ENST0000036850832431860_188202348.0TransmembraneHelical
TgeneROS1chr4:25678323chr6:117650608ENST0000036850830431860_188202348.0TransmembraneHelical
TgeneROS1chr4:25678324chr6:117645578ENST0000036850832431860_188202348.0TransmembraneHelical
TgeneROS1chr4:25678324chr6:117650609ENST0000036850830431860_188202348.0TransmembraneHelical
TgeneROS1chr4:25678324chr6:117650610ENST0000036850830431860_188202348.0TransmembraneHelical

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result
SLC34A2chr425665952ENST00000382051ROS1chr6117645580ENST00000368507
SLC34A2chr425665952ENST00000382051ROS1chr6117650609ENST00000368507
SLC34A2chr425665952ENST00000503434ROS1chr6117645580ENST00000368507
SLC34A2chr425665952ENST00000503434ROS1chr6117650609ENST00000368507
SLC34A2chr425665952ENST00000504570ROS1chr6117645580ENST00000368507
SLC34A2chr425665952ENST00000504570ROS1chr6117650609ENST00000368507
SLC34A2chr425678323ENST00000382051ROS1chr6117645577ENST00000368507
SLC34A2chr425678323ENST00000382051ROS1chr6117650608ENST00000368507
SLC34A2chr425678324ENST00000382051ROS1chr6117645578ENST00000368507

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Related Drugs to SLC34A2-ROS1

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SLC34A2-ROS1

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
SLC34A2ROS1Lung AdenocarcinomaMyCancerGenome
SLC34A2ROS1Dedifferentiated LiposarcomaMyCancerGenome
SLC34A2ROS1Breast Invasive Ductal CarcinomaMyCancerGenome
SLC34A2ROS1Anaplastic GangliogliomaMyCancerGenome
SLC34A2ROS1Cancer Of Unknown PrimaryMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC34A2C0155912Pulmonary Alveolar Microlithiasis4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneSLC34A2C0007131Non-Small Cell Lung Carcinoma2CTD_human
HgeneSLC34A2C0013221Drug toxicity1CTD_human
HgeneSLC34A2C0041755Adverse reaction to drug1CTD_human
TgeneROS1C0007131Non-Small Cell Lung Carcinoma4CTD_human
TgeneROS1C0017638Glioma1CTD_human
TgeneROS1C0025202melanoma1CTD_human
TgeneROS1C0152013Adenocarcinoma of lung (disorder)1CGI;CTD_human
TgeneROS1C0259783mixed gliomas1CTD_human
TgeneROS1C0555198Malignant Glioma1CTD_human