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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:SOX6-BTBD10

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SOX6-BTBD10
FusionPDB ID: 85343
FusionGDB2.0 ID: 85343
HgeneTgene
Gene symbol

SOX6

BTBD10

Gene ID

55553

84280

Gene nameSRY-box transcription factor 6BTB domain containing 10
SynonymsHSSOX6|SOXDGMRP-1|GMRP1
Cytomap

11p15.2

11p15.3

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor SOX-6SRY (sex determining region Y)-box 6SRY-box 6SRY-box containing gene 6BTB/POZ domain-containing protein 10BTB (POZ) domain containing 10BTB (broad-complex tramtrack and bric-a-brac/pox virus and zinc finger) domain-containing protein 10K+ channel tetramerization proteinepididymis secretory sperm binding proteinglucose
Modification date2020031320200327
UniProtAcc.

Q9BSF8

Main function of 5'-partner protein: FUNCTION: Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells. {ECO:0000250|UniProtKB:Q80X66}.
Ensembl transtripts involved in fusion geneENST idsENST00000316399, ENST00000352083, 
ENST00000396356, ENST00000527619, 
ENST00000528252, ENST00000528429, 
ENST00000533658, 
ENST00000532261, 
ENST00000528120, ENST00000278174, 
ENST00000530907, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 12 X 8=12486 X 5 X 4=120
# samples 146
** MAII scorelog2(14/1248*10)=-3.15611920191728
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: SOX6 [Title/Abstract] AND BTBD10 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: SOX6 [Title/Abstract] AND BTBD10 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SOX6(16339992)-BTBD10(13427403), # samples:3
Anticipated loss of major functional domain due to fusion event.SOX6-BTBD10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SOX6-BTBD10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SOX6-BTBD10 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSOX6

GO:0032332

positive regulation of chondrocyte differentiation

21401405

HgeneSOX6

GO:0061036

positive regulation of cartilage development

21401405

HgeneSOX6

GO:0071560

cellular response to transforming growth factor beta stimulus

21401405

HgeneSOX6

GO:2000741

positive regulation of mesenchymal stem cell differentiation

21401405



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:16339992/chr11:13427403)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across SOX6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BTBD10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000316399SOX6chr1116339992-ENST00000278174BTBD10chr1113427403-191646601085361
ENST00000316399SOX6chr1116339992-ENST00000530907BTBD10chr1113427403-123446601085361
ENST00000316399SOX6chr1116339992-ENST00000528120BTBD10chr1113427403-121546601085361
ENST00000396356SOX6chr1116339992-ENST00000278174BTBD10chr1113427403-1973523391142367
ENST00000396356SOX6chr1116339992-ENST00000530907BTBD10chr1113427403-1291523391142367
ENST00000396356SOX6chr1116339992-ENST00000528120BTBD10chr1113427403-1272523391142367
ENST00000352083SOX6chr1116339992-ENST00000278174BTBD10chr1113427403-1973523391142367
ENST00000352083SOX6chr1116339992-ENST00000530907BTBD10chr1113427403-1291523391142367
ENST00000352083SOX6chr1116339992-ENST00000528120BTBD10chr1113427403-1272523391142367
ENST00000527619SOX6chr1116339992-ENST00000278174BTBD10chr1113427403-20876371831256357
ENST00000527619SOX6chr1116339992-ENST00000530907BTBD10chr1113427403-14056371831256357
ENST00000527619SOX6chr1116339992-ENST00000528120BTBD10chr1113427403-13866371831256357
ENST00000316399SOX6chr1116339992-ENST00000278174BTBD10chr1113410688-16074660776258
ENST00000316399SOX6chr1116339992-ENST00000530907BTBD10chr1113410688-9254660776258
ENST00000396356SOX6chr1116339992-ENST00000278174BTBD10chr1113410688-166452339833264
ENST00000396356SOX6chr1116339992-ENST00000530907BTBD10chr1113410688-98252339833264
ENST00000352083SOX6chr1116339992-ENST00000278174BTBD10chr1113410688-166452339833264
ENST00000352083SOX6chr1116339992-ENST00000530907BTBD10chr1113410688-98252339833264
ENST00000528252SOX6chr1116339992-ENST00000528120BTBD10chr1113410688-107663677946289
ENST00000527619SOX6chr1116339992-ENST00000278174BTBD10chr1113410688-1778637183947254
ENST00000527619SOX6chr1116339992-ENST00000530907BTBD10chr1113410688-1096637183947254
ENST00000528429SOX6chr1116339992-ENST00000528120BTBD10chr1113410688-95351314823269

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000316399ENST00000278174SOX6chr1116339992-BTBD10chr1113427403-0.0003549530.999645
ENST00000316399ENST00000530907SOX6chr1116339992-BTBD10chr1113427403-0.0010581890.99894184
ENST00000316399ENST00000528120SOX6chr1116339992-BTBD10chr1113427403-0.0010997110.9989003
ENST00000396356ENST00000278174SOX6chr1116339992-BTBD10chr1113427403-0.0003414860.99965847
ENST00000396356ENST00000530907SOX6chr1116339992-BTBD10chr1113427403-0.0008263990.9991736
ENST00000396356ENST00000528120SOX6chr1116339992-BTBD10chr1113427403-0.0008455140.99915445
ENST00000352083ENST00000278174SOX6chr1116339992-BTBD10chr1113427403-0.0003414860.99965847
ENST00000352083ENST00000530907SOX6chr1116339992-BTBD10chr1113427403-0.0008263990.9991736
ENST00000352083ENST00000528120SOX6chr1116339992-BTBD10chr1113427403-0.0008455140.99915445
ENST00000527619ENST00000278174SOX6chr1116339992-BTBD10chr1113427403-0.0003417970.9996582
ENST00000527619ENST00000530907SOX6chr1116339992-BTBD10chr1113427403-0.0008601080.9991399
ENST00000527619ENST00000528120SOX6chr1116339992-BTBD10chr1113427403-0.0009038860.99909616
ENST00000316399ENST00000278174SOX6chr1116339992-BTBD10chr1113410688-0.001046050.99895394
ENST00000316399ENST00000530907SOX6chr1116339992-BTBD10chr1113410688-0.002526860.99747306
ENST00000396356ENST00000278174SOX6chr1116339992-BTBD10chr1113410688-0.0009901960.9990097
ENST00000396356ENST00000530907SOX6chr1116339992-BTBD10chr1113410688-0.002561470.99743855
ENST00000352083ENST00000278174SOX6chr1116339992-BTBD10chr1113410688-0.0009901960.9990097
ENST00000352083ENST00000530907SOX6chr1116339992-BTBD10chr1113410688-0.002561470.99743855
ENST00000528252ENST00000528120SOX6chr1116339992-BTBD10chr1113410688-0.0021517040.9978483
ENST00000527619ENST00000278174SOX6chr1116339992-BTBD10chr1113410688-0.0019117140.9980883
ENST00000527619ENST00000530907SOX6chr1116339992-BTBD10chr1113410688-0.0045423050.99545777
ENST00000528429ENST00000528120SOX6chr1116339992-BTBD10chr1113410688-0.0017435030.9982565

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for SOX6-BTBD10

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
SOX6chr1116339992BTBD10chr1113410688466155QKKLEEMTRTEQEGYPTYKEKVKKRP
SOX6chr1116339992BTBD10chr1113410688513166QKKLEEMTRTEQEGYPTYKEKVKKRP
SOX6chr1116339992BTBD10chr1113410688523161QKKLEEMTRTEQEGYPTYKEKVKKRP
SOX6chr1116339992BTBD10chr1113410688637151QKKLEEMTRTEQEGYPTYKEKVKKRP
SOX6chr1116339992BTBD10chr1113427403466155QKKLEEMTRTEQEGALMHELSNDGAR
SOX6chr1116339992BTBD10chr1113427403523161QKKLEEMTRTEQEGALMHELSNDGAR
SOX6chr1116339992BTBD10chr1113427403637151QKKLEEMTRTEQEGALMHELSNDGAR

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Potential FusionNeoAntigen Information of SOX6-BTBD10 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
SOX6-BTBD10_16339992_13410688.msa
SOX6-BTBD10_16339992_13427403.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:01EQEGYPTY0.93290.9721018
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:01MTRTEQEGY0.99670.8802615
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:03TEQEGYPTY0.99430.9827918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:01TEQEGYPTY0.99280.9644918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:17MTRTEQEGY0.98570.9327615
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:05TEQEGYPTY0.97950.5307918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B47:01TEQEGYPTY0.90720.7623918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B50:02TEQEGYPTY0.55960.7743918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B45:01TEQEGYPTY0.53840.9209918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:02TEQEGYPTY0.3840.9901918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B41:01TEQEGYPTY0.1970.9631918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:03TEQEGYPTY0.10740.9663918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:18TEQEGYPTY0.07860.94918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B50:01TEQEGYPTY0.0310.8039918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:01RTEQEGYPTY0.95390.9622818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:17RTEQEGYPTY0.94080.9901818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:25RTEQEGYPTY0.93890.9876818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:16RTEQEGYPTY0.78920.9892818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:03RTEQEGYPTY0.75390.9643818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:05RTEQEGYPTY0.45510.6275818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:03RTEQEGYPTY0.43660.9363818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:01RTEQEGYPTY0.24050.9406818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:03EEMTRTEQEGY0.99970.971415
SOX6-BTBD10chr1116339992chr1113410688466HLA-A11:03RTEQEGYPTYK0.99920.6211819
SOX6-BTBD10chr1116339992chr1113410688466HLA-A11:04RTEQEGYPTYK0.99870.5259819
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:01EEMTRTEQEGY0.97290.7415415
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:18TRTEQEGYPTY0.97170.8853718
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:03TRTEQEGYPTY0.84450.8985718
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:01TRTEQEGYPTY0.76360.8876718
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:09TEQEGYPTY0.99460.5494918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B40:03TEQEGYPTY0.91870.6679918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:10TEQEGYPTY0.76680.6346918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:05TEQEGYPTY0.60530.9713918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:31TEQEGYPTY0.52760.9759918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:21TEQEGYPTY0.37660.9788918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:05RTEQEGYPTY0.85590.9694818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:08RTEQEGYPTY0.64230.5024818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:09RTEQEGYPTY0.57980.6275818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:09EEMTRTEQEGY0.99970.5568415
SOX6-BTBD10chr1116339992chr1113410688466HLA-A11:01RTEQEGYPTYK0.99930.5954819
SOX6-BTBD10chr1116339992chr1113410688466HLA-C07:46TRTEQEGYPTY0.99070.9236718
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:08TRTEQEGYPTY0.93030.5799718
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:09TRTEQEGYPTY0.87820.6838718
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:04EQEGYPTY0.95860.97621018
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:06EQEGYPTY0.93930.97561018
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:07EQEGYPTY0.93470.95361018
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:05EQEGYPTY0.93290.9721018
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:08EQEGYPTY0.92560.96631018
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:11EQEGYPTY0.88170.96971018
SOX6-BTBD10chr1116339992chr1113410688466HLA-B35:20EQEGYPTY0.86950.98311018
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:34MTRTEQEGY0.99670.8802615
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:33MTRTEQEGY0.99670.8802615
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:125MTRTEQEGY0.99670.8802615
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:135MTRTEQEGY0.99620.8756615
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:11MTRTEQEGY0.99450.8409615
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:04TEQEGYPTY0.99430.9693918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:07TEQEGYPTY0.99430.9827918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:26TEQEGYPTY0.99430.9827918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:13TEQEGYPTY0.99430.9827918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:07TEQEGYPTY0.99360.9425918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:08MTRTEQEGY0.99350.829615
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:05TEQEGYPTY0.99280.9644918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:08TEQEGYPTY0.99260.9613918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:06TEQEGYPTY0.98980.969918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:03TEQEGYPTY0.98380.9615918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B57:04MTRTEQEGY0.97890.7677615
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:12MTRTEQEGY0.96840.7924615
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:11TEQEGYPTY0.89580.9623918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:20TEQEGYPTY0.59730.9825918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B40:04TEQEGYPTY0.59620.7947918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:12TEQEGYPTY0.56050.9558918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B35:28TEQEGYPTY0.54410.9837918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B35:20TEQEGYPTY0.5120.9858918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B41:03TEQEGYPTY0.19780.7453918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:53TEQEGYPTY0.15750.9718918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B48:02TEQEGYPTY0.13160.9804918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:54TEQEGYPTY0.03510.9672918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B50:04TEQEGYPTY0.0310.8039918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B50:05TEQEGYPTY0.0310.8039918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:68TEQEGYPTY0.00770.8655918
SOX6-BTBD10chr1116339992chr1113410688466HLA-B57:04RTEQEGYPTY0.97290.9487818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:34RTEQEGYPTY0.95390.9622818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:33RTEQEGYPTY0.95390.9622818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:125RTEQEGYPTY0.95390.9622818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:135RTEQEGYPTY0.95030.9675818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:12RTEQEGYPTY0.94730.9082818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:39RTEQEGYPTY0.9390.9736818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:50RTEQEGYPTY0.90420.9358818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:53RTEQEGYPTY0.88790.9498818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:35RTEQEGYPTY0.88680.9663818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:20RTEQEGYPTY0.86730.9781818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B35:28RTEQEGYPTY0.8230.9798818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B15:54RTEQEGYPTY0.79710.9412818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B48:02RTEQEGYPTY0.67050.9757818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:11TEQEGYPTYK0.670.9621919
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:11RTEQEGYPTY0.63480.9485818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:26RTEQEGYPTY0.43660.9363818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:07RTEQEGYPTY0.43660.9363818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:13RTEQEGYPTY0.43660.9363818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:05RTEQEGYPTY0.24050.9406818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:08RTEQEGYPTY0.22340.9339818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:06RTEQEGYPTY0.20980.9442818
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:13EEMTRTEQEGY0.99970.971415
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:26EEMTRTEQEGY0.99970.971415
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:07EEMTRTEQEGY0.99970.971415
SOX6-BTBD10chr1116339992chr1113410688466HLA-A11:02RTEQEGYPTYK0.99930.5954819
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:11EEMTRTEQEGY0.98910.6836415
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:06EEMTRTEQEGY0.97760.7625415
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:03EEMTRTEQEGY0.97570.7213415
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:05EEMTRTEQEGY0.97290.7415415
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:11TRTEQEGYPTY0.9620.8708718
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:04TRTEQEGYPTY0.87180.9003718
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:07TRTEQEGYPTY0.84450.8985718
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:26TRTEQEGYPTY0.84450.8985718
SOX6-BTBD10chr1116339992chr1113410688466HLA-B44:13TRTEQEGYPTY0.84450.8985718
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:03TRTEQEGYPTY0.82290.8814718
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:06TRTEQEGYPTY0.78070.8939718
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:05TRTEQEGYPTY0.76360.8876718
SOX6-BTBD10chr1116339992chr1113410688466HLA-B18:08TRTEQEGYPTY0.73620.8922718
SOX6-BTBD10chr1116339992chr1113427403466HLA-B18:01TEQEGALM0.98460.9849917
SOX6-BTBD10chr1116339992chr1113427403466HLA-B39:24TRTEQEGAL0.99520.748716
SOX6-BTBD10chr1116339992chr1113427403466HLA-B39:01TRTEQEGAL0.99370.9397716
SOX6-BTBD10chr1116339992chr1113427403466HLA-B44:03QEGALMHEL0.99070.98581120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B47:01QEGALMHEL0.98840.74321120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B38:02TRTEQEGAL0.98740.9796716
SOX6-BTBD10chr1116339992chr1113427403466HLA-B13:01QEGALMHEL0.98380.97961120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B18:01TEQEGALMH0.97940.9824918
SOX6-BTBD10chr1116339992chr1113427403466HLA-B14:01TRTEQEGAL0.97450.9167716
SOX6-BTBD10chr1116339992chr1113427403466HLA-B14:02TRTEQEGAL0.97450.9167716
SOX6-BTBD10chr1116339992chr1113427403466HLA-B45:01QEGALMHEL0.95290.97461120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B18:01QEGALMHEL0.91440.96211120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B15:10TRTEQEGAL0.90620.8161716
SOX6-BTBD10chr1116339992chr1113427403466HLA-B39:13QEGALMHEL0.89510.99451120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B47:01TEQEGALMH0.88180.882918
SOX6-BTBD10chr1116339992chr1113427403466HLA-B15:37TRTEQEGAL0.73710.8138716
SOX6-BTBD10chr1116339992chr1113427403466HLA-B41:02QEGALMHEL0.64030.73331120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B41:01QEGALMHEL0.4970.99481120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B07:10TRTEQEGAL0.03630.5927716
SOX6-BTBD10chr1116339992chr1113427403466HLA-B45:01EEMTRTEQEGA0.99830.9745415
SOX6-BTBD10chr1116339992chr1113427403466HLA-B39:13TEQEGALMHEL0.99740.9892920
SOX6-BTBD10chr1116339992chr1113427403466HLA-B41:02TEQEGALMHEL0.99460.5862920
SOX6-BTBD10chr1116339992chr1113427403466HLA-C05:09RTEQEGALM0.99980.9892817
SOX6-BTBD10chr1116339992chr1113427403466HLA-C08:15RTEQEGALM0.99970.9935817
SOX6-BTBD10chr1116339992chr1113427403466HLA-B40:06QEGALMHEL0.99930.86591120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B44:10QEGALMHEL0.99630.63051120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B39:09TRTEQEGAL0.99440.8947716
SOX6-BTBD10chr1116339992chr1113427403466HLA-B40:03QEGALMHEL0.99310.65971120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B39:12TRTEQEGAL0.99260.9419716
SOX6-BTBD10chr1116339992chr1113427403466HLA-B44:09TEQEGALMH0.99210.5795918
SOX6-BTBD10chr1116339992chr1113427403466HLA-B39:05TRTEQEGAL0.98890.938716
SOX6-BTBD10chr1116339992chr1113427403466HLA-B44:09QEGALMHEL0.98050.54391120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B40:03TEQEGALMH0.97650.8097918
SOX6-BTBD10chr1116339992chr1113427403466HLA-B39:08QEGALMHEL0.8720.98961120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B14:03TRTEQEGAL0.47490.8965716
SOX6-BTBD10chr1116339992chr1113427403466HLA-B44:10TEQEGALMHEL0.99960.5567920
SOX6-BTBD10chr1116339992chr1113427403466HLA-B39:08TEQEGALMHEL0.99820.9607920
SOX6-BTBD10chr1116339992chr1113427403466HLA-B18:05TEQEGALM0.98460.9849917
SOX6-BTBD10chr1116339992chr1113427403466HLA-B18:11TEQEGALM0.93370.9869917
SOX6-BTBD10chr1116339992chr1113427403466HLA-B41:03TEQEGALM0.84670.9584917
SOX6-BTBD10chr1116339992chr1113427403466HLA-C04:03RTEQEGALM0.99980.9846817
SOX6-BTBD10chr1116339992chr1113427403466HLA-C05:01RTEQEGALM0.99980.9892817
SOX6-BTBD10chr1116339992chr1113427403466HLA-C08:02RTEQEGALM0.99970.9935817
SOX6-BTBD10chr1116339992chr1113427403466HLA-B40:04QEGALMHEL0.99930.78781120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B39:31TRTEQEGAL0.9940.939716
SOX6-BTBD10chr1116339992chr1113427403466HLA-B44:07QEGALMHEL0.99070.98581120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B44:26QEGALMHEL0.99070.98581120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B44:13QEGALMHEL0.99070.98581120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B18:05TEQEGALMH0.97940.9824918
SOX6-BTBD10chr1116339992chr1113427403466HLA-B18:08TEQEGALMH0.97930.9878918
SOX6-BTBD10chr1116339992chr1113427403466HLA-B18:06TEQEGALMH0.97670.9896918
SOX6-BTBD10chr1116339992chr1113427403466HLA-B18:04TEQEGALMH0.97410.9854918
SOX6-BTBD10chr1116339992chr1113427403466HLA-B18:03TEQEGALMH0.92750.9803918
SOX6-BTBD10chr1116339992chr1113427403466HLA-B18:11QEGALMHEL0.92490.96641120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B18:05QEGALMHEL0.91440.96211120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B18:06QEGALMHEL0.89570.97021120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B18:08QEGALMHEL0.89370.96581120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B15:09TRTEQEGAL0.88460.9622716
SOX6-BTBD10chr1116339992chr1113427403466HLA-B39:02QEGALMHEL0.88330.99461120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B18:03QEGALMHEL0.87950.95551120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B41:03QEGALMHEL0.87390.84751120
SOX6-BTBD10chr1116339992chr1113427403466HLA-B18:11TEQEGALMH0.74330.9853918
SOX6-BTBD10chr1116339992chr1113427403466HLA-B40:04TEQEGALMHEL0.99990.7845920
SOX6-BTBD10chr1116339992chr1113427403466HLA-B39:02TEQEGALMHEL0.99750.9898920
SOX6-BTBD10chr1116339992chr1113427403466HLA-B41:03TEQEGALMHEL0.99470.7899920

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Potential FusionNeoAntigen Information of SOX6-BTBD10 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
SOX6-BTBD10_16339992_13410688.msa
SOX6-BTBD10_16339992_13427403.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
SOX6-BTBD10chr1116339992chr1113410688466DRB1-0802QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-0804QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-0806QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-0809QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-0820QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-0821QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-0824QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-0828QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-0831QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1101QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1103QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1104QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1104KKLEEMTRTEQEGYP116
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1105QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1106QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1108QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1109QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1110QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1112QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1113QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1115QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1118QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1119QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1124QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1125QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1127QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1128QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1129QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1131QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1132QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1133QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1134QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1135QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1135KKLEEMTRTEQEGYP116
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1137QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1138QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1138KKLEEMTRTEQEGYP116
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1139QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1141QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1142QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1142KKLEEMTRTEQEGYP116
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1143QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1143KKLEEMTRTEQEGYP116
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1144QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1144KKLEEMTRTEQEGYP116
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1146QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1146KKLEEMTRTEQEGYP116
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1147QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1149QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1150QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1150KKLEEMTRTEQEGYP116
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1151QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1154QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1156QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1156KKLEEMTRTEQEGYP116
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1157QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1158QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1158KKLEEMTRTEQEGYP116
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1160QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1160KKLEEMTRTEQEGYP116
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1161QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1162QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1163QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1166QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1167QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1169QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1174QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1175QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1176QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1177QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1177KKLEEMTRTEQEGYP116
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1178QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1178KKLEEMTRTEQEGYP116
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1180QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1181QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1183QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1184QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1185QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1187QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1188QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1188KKLEEMTRTEQEGYP116
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1189QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1190QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1191QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1192QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1193QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1194QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1195QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1196QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1305QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1306QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1307QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1309QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1311QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1311KKLEEMTRTEQEGYP116
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1314QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1318QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1324QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1326QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1337QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1342QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1342KKLEEMTRTEQEGYP116
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1344QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1347QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1350QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1356QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1360QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1362QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1382QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1402QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1406QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1409QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1412QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1415QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1417QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1420QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1421QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1429QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1430QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1433QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1434QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1437QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1441QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1453QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1474QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1480QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1481QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1483QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1484QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113410688466DRB1-1494QKKLEEMTRTEQEGY015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-0802QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-0804QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-0806QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-0809QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-0813QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-0820QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-0820KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-0821QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-0822QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-0824QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-0828QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-0831QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-0831KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1101QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1103QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1104QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1104KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1105QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1106QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1106KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1108QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1109QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1110QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1112QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1113QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1115QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1118QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1118KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1119QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1124QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1125QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1127QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1128QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1129QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1131QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1132QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1133QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1134QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1135QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1135KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1137QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1138QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1138KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1139QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1141QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1142QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1142KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1143QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1143KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1144QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1144KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1146QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1146KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1147QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1147KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1149QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1150QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1150KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1151QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1154QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1156QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1156KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1157QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1157KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1158QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1158KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1159QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1160QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1160KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1161QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1162QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1163QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1164QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1166QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1167QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1169QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1172QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1173QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1174QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1175QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1176QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1177QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1177KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1178QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1178KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1180QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1181QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1183QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1183KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1184QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1184KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1185QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1187QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1188QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1188KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1189QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1190QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1191QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1192QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1193QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1194QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1195QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1196QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1305QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1306QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1306KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1307QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1309QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-13100QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1311QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1311KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1314QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1318QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1324QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1326QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1337QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1342QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1342KKLEEMTRTEQEGAL116
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1344QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1346QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1347QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1349QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1350QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1356QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1358QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1360QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1362QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1382QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1385QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1386QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1389QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1402QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1406QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1409QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1412QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1415QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1417QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1420QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1421QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1422QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1425QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1427QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1429QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1430QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1433QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1434QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1437QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1441QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1452QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1453QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1465QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1473QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1474QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1478QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1480QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1481QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1483QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1484QKKLEEMTRTEQEGA015
SOX6-BTBD10chr1116339992chr1113427403466DRB1-1494QKKLEEMTRTEQEGA015

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Fusion breakpoint peptide structures of SOX6-BTBD10

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
6042MTRTEQEGALMHELSOX6BTBD10chr1116339992chr1113427403466
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
6043MTRTEQEGYPTYKESOX6BTBD10chr1116339992chr1113410688466

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of SOX6-BTBD10

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN6042MTRTEQEGALMHEL-5.90184-6.56334
HLA-B14:023BVN6042MTRTEQEGALMHEL-5.90155-6.13685
HLA-B52:013W396042MTRTEQEGALMHEL-5.43665-6.09815
HLA-B52:013W396042MTRTEQEGALMHEL-4.97988-5.21518
HLA-A24:025HGA6042MTRTEQEGALMHEL-6.69451-7.35601
HLA-A24:025HGA6042MTRTEQEGALMHEL-3.95655-4.19185
HLA-B44:053DX86042MTRTEQEGALMHEL-4.30194-4.96344
HLA-B44:053DX86042MTRTEQEGALMHEL-3.80732-4.04262
HLA-A02:016TDR6042MTRTEQEGALMHEL-4.9611-5.1964
HLA-B14:023BVN6043MTRTEQEGYPTYKE-7.9962-8.1096
HLA-B14:023BVN6043MTRTEQEGYPTYKE-5.70842-6.74372
HLA-B52:013W396043MTRTEQEGYPTYKE-6.83737-6.95077
HLA-B52:013W396043MTRTEQEGYPTYKE-4.4836-5.5189
HLA-A11:014UQ26043MTRTEQEGYPTYKE-10.0067-10.1201
HLA-A11:014UQ26043MTRTEQEGYPTYKE-9.03915-10.0745
HLA-A24:025HGA6043MTRTEQEGYPTYKE-6.56204-6.67544
HLA-A24:025HGA6043MTRTEQEGYPTYKE-5.42271-6.45801
HLA-B44:053DX86043MTRTEQEGYPTYKE-7.85648-8.89178
HLA-B44:053DX86043MTRTEQEGYPTYKE-5.3978-5.5112
HLA-A02:016TDR6043MTRTEQEGYPTYKE-3.37154-4.40684

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Vaccine Design for the FusionNeoAntigens of SOX6-BTBD10

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
SOX6-BTBD10chr1116339992chr11134106881018EQEGYPTYAACAAGAGGGTTATCCTACCTACA
SOX6-BTBD10chr1116339992chr1113410688415EEMTRTEQEGYAGGAAATGACTCGGACTGAACAAGAGGGTTATC
SOX6-BTBD10chr1116339992chr1113410688615MTRTEQEGYTGACTCGGACTGAACAAGAGGGTTATC
SOX6-BTBD10chr1116339992chr1113410688718TRTEQEGYPTYCTCGGACTGAACAAGAGGGTTATCCTACCTACA
SOX6-BTBD10chr1116339992chr1113410688818RTEQEGYPTYGGACTGAACAAGAGGGTTATCCTACCTACA
SOX6-BTBD10chr1116339992chr1113410688819RTEQEGYPTYKGGACTGAACAAGAGGGTTATCCTACCTACAAAG
SOX6-BTBD10chr1116339992chr1113410688918TEQEGYPTYCTGAACAAGAGGGTTATCCTACCTACA
SOX6-BTBD10chr1116339992chr1113410688919TEQEGYPTYKCTGAACAAGAGGGTTATCCTACCTACAAAG
SOX6-BTBD10chr1116339992chr11134274031120QEGALMHELAAGAGGGTGCCCTAATGCATGAGTTAT
SOX6-BTBD10chr1116339992chr1113427403415EEMTRTEQEGAAGGAAATGACTCGGACTGAACAAGAGGGTGCCC
SOX6-BTBD10chr1116339992chr1113427403716TRTEQEGALCTCGGACTGAACAAGAGGGTGCCCTAA
SOX6-BTBD10chr1116339992chr1113427403817RTEQEGALMGGACTGAACAAGAGGGTGCCCTAATGC
SOX6-BTBD10chr1116339992chr1113427403917TEQEGALMCTGAACAAGAGGGTGCCCTAATGC
SOX6-BTBD10chr1116339992chr1113427403918TEQEGALMHCTGAACAAGAGGGTGCCCTAATGCATG
SOX6-BTBD10chr1116339992chr1113427403920TEQEGALMHELCTGAACAAGAGGGTGCCCTAATGCATGAGTTAT

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
SOX6-BTBD10chr1116339992chr1113410688015QKKLEEMTRTEQEGYAGAAGAAGCTTGAGGAAATGACTCGGACTGAACAAGAGGGTTATC
SOX6-BTBD10chr1116339992chr1113410688116KKLEEMTRTEQEGYPAGAAGCTTGAGGAAATGACTCGGACTGAACAAGAGGGTTATCCTA
SOX6-BTBD10chr1116339992chr1113427403015QKKLEEMTRTEQEGAAGAAGAAGCTTGAGGAAATGACTCGGACTGAACAAGAGGGTGCCC
SOX6-BTBD10chr1116339992chr1113427403116KKLEEMTRTEQEGALAGAAGCTTGAGGAAATGACTCGGACTGAACAAGAGGGTGCCCTAA

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Information of the samples that have these potential fusion neoantigens of SOX6-BTBD10

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
KICHSOX6-BTBD10chr1116339992ENST00000316399chr1113410688ENST00000278174TCGA-KL-8339-01A
KICHSOX6-BTBD10chr1116339992ENST00000316399chr1113427403ENST00000278174TCGA-KL-8339-01A

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Potential target of CAR-T therapy development for SOX6-BTBD10

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to SOX6-BTBD10

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SOX6-BTBD10

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource