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Fusion Protein:SRSF3-DNAJC7

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SRSF3-DNAJC7
	FusionPDB ID: 86610
	FusionGDB2.0 ID: 86610
		Hgene	Tgene
	Gene symbol	SRSF3	DNAJC7
	Gene ID	6428	7266
	Gene name	serine and arginine rich splicing factor 3	DnaJ heat shock protein family (Hsp40) member C7
	Synonyms	SFRS3\|SRp20	DJ11\|DJC7\|TPR2\|TTC2
	Cytomap	6p21.31-p21.2	17q21.2
	Type of gene	protein-coding	protein-coding
	Description	serine/arginine-rich splicing factor 3epididymis secretory sperm binding proteinpre-mRNA splicing factor SRp20pre-mRNA-splicing factor SRP20splicing factor, arginine/serine-rich 3splicing factor, arginine/serine-rich, 20-kD	dnaJ homolog subfamily C member 7DnaJ (Hsp40) homolog, subfamily C, member 7TPR repeat protein 2tetratricopeptide repeat domain 2tetratricopeptide repeat protein 2
	Modification date	20200313	20200313
	UniProtAcc	.	Q99615 Main function of 5'-partner protein: FUNCTION: Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity). {ECO:0000250, ECO:0000269\|PubMed:12853476, ECO:0000269\|PubMed:18620420}.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000339436, ENST00000373715,	ENST00000589547, ENST00000316603, ENST00000426588, ENST00000457167,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 8 X 4=320	9 X 8 X 7=504
	# samples	12	12
	** MAII score	log2(12/320*10)=-1.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/504*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: SRSF3 [Title/Abstract] AND DNAJC7 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: SRSF3 [Title/Abstract] AND DNAJC7 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SRSF3(36566760)-DNAJC7(40135654), # samples:1
Anticipated loss of major functional domain due to fusion event.	SRSF3-DNAJC7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SRSF3-DNAJC7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SRSF3-DNAJC7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SRSF3-DNAJC7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SRSF3	GO:0006406	mRNA export from nucleus	28984244
Hgene	SRSF3	GO:0048024	regulation of mRNA splicing, via spliceosome	26876937
Tgene	DNAJC7	GO:0051085	chaperone cofactor-dependent protein refolding	12853476\|18620420

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:36566760/chr17:40135654)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across SRSF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DNAJC7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000373715	SRSF3	chr6	36566760	+	ENST00000457167	DNAJC7	chr17	40135654	-	1232	457	32	931	299
ENST00000373715	SRSF3	chr6	36566760	+	ENST00000426588	DNAJC7	chr17	40135654	-	1186	457	32	931	299
ENST00000373715	SRSF3	chr6	36566760	+	ENST00000316603	DNAJC7	chr17	40135654	-	1001	457	32	931	299
ENST00000339436	SRSF3	chr6	36566760	+	ENST00000457167	DNAJC7	chr17	40135654	-	1232	457	32	931	299
ENST00000339436	SRSF3	chr6	36566760	+	ENST00000426588	DNAJC7	chr17	40135654	-	1186	457	32	931	299
ENST00000339436	SRSF3	chr6	36566760	+	ENST00000316603	DNAJC7	chr17	40135654	-	1001	457	32	931	299

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000373715	ENST00000457167	SRSF3	chr6	36566760	+	DNAJC7	chr17	40135654	-	0.001921085	0.99807894
ENST00000373715	ENST00000426588	SRSF3	chr6	36566760	+	DNAJC7	chr17	40135654	-	0.002392136	0.9976078
ENST00000373715	ENST00000316603	SRSF3	chr6	36566760	+	DNAJC7	chr17	40135654	-	0.002994826	0.99700516
ENST00000339436	ENST00000457167	SRSF3	chr6	36566760	+	DNAJC7	chr17	40135654	-	0.001921085	0.99807894
ENST00000339436	ENST00000426588	SRSF3	chr6	36566760	+	DNAJC7	chr17	40135654	-	0.002392136	0.9976078
ENST00000339436	ENST00000316603	SRSF3	chr6	36566760	+	DNAJC7	chr17	40135654	-	0.002994826	0.99700516

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for SRSF3-DNAJC7

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
SRSF3	chr6	36566760	DNAJC7	chr17	40135654	457	141	RDDYRRRSPPPRRSYMDTEQYEEAVR

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Potential FusionNeoAntigen Information of SRSF3-DNAJC7 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

SRSF3-DNAJC7_36566760_40135654.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:25	RSYMDTEQY	0.999	0.9178	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:01	RSYMDTEQY	0.9976	0.9183	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:17	RSYMDTEQY	0.9946	0.8954	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:01	RSPPPRRSY	0.9938	0.8866	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:25	RSPPPRRSY	0.9926	0.8601	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B57:01	RSYMDTEQY	0.9916	0.9578	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B58:01	RSYMDTEQY	0.9859	0.8937	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B58:02	RSYMDTEQY	0.9834	0.9073	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B57:01	RSPPPRRSY	0.9831	0.9561	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:17	RSPPPRRSY	0.9795	0.8633	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:16	RSYMDTEQY	0.9788	0.696	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B58:02	RSPPPRRSY	0.9373	0.8729	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B57:03	RSYMDTEQY	0.9226	0.952	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-A30:08	RSPPPRRSY	0.9043	0.7452	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B58:01	RSPPPRRSY	0.9005	0.8746	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:03	RSYMDTEQY	0.8894	0.7746	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:03	RSPPPRRSY	0.7679	0.6867	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B35:03	SPPPRRSYM	0.6247	0.7842	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-A32:13	RSPPPRRSY	0.5488	0.9431	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-A32:13	RSYMDTEQY	0.4474	0.9385	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B35:04	SPPPRRSYM	0.3173	0.7231	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B35:02	SPPPRRSYM	0.3173	0.7231	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:02	RRSPPPRRSY	0.9999	0.658	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:05	RRSPPPRRSY	0.9999	0.8955	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:04	RRSPPPRRSY	0.9998	0.7554	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:05	RRSYMDTEQY	0.9997	0.925	11	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:04	RRSYMDTEQY	0.9996	0.7944	11	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:02	RRSYMDTEQY	0.9995	0.7065	11	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:03	RRSPPPRRSY	0.8936	0.7683	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:18	RRSPPPRRSY	0.8148	0.7271	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B58:02	RRSPPPRRSY	0.7593	0.9236	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:17	RRSYMDTEQY	0.7256	0.8836	11	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:16	RRSYMDTEQY	0.5432	0.7054	11	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B58:01	RRSYMDTEQY	0.489	0.9019	11	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:05	RRSPPPRRSYM	1	0.8666	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:02	RRSPPPRRSYM	1	0.6363	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:05	RRRSPPPRRSY	0.9999	0.8181	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:04	RRSPPPRRSYM	0.9999	0.7377	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:02	RRRSPPPRRSY	0.9999	0.532	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:04	RRRSPPPRRSY	0.9998	0.7321	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B07:02	RRSPPPRRSYM	0.9634	0.5046	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B07:10	RRSPPPRRSYM	0.9572	0.5572	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B58:02	RRRSPPPRRSY	0.9552	0.9117	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:07	RSYMDTEQY	0.9953	0.761	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:14	RRSPPPRRS	0.9922	0.862	5	14
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:07	RSPPPRRSY	0.9909	0.6819	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:05	RSYMDTEQY	0.9864	0.8588	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C15:04	RSYMDTEQY	0.9264	0.8658	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:04	RSYMDTEQY	0.9232	0.9222	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:05	RSPPPRRSY	0.8839	0.8346	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:19	RSPPPRRSY	0.8747	0.7385	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:95	RSPPPRRSY	0.8648	0.6826	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:27	RSPPPRRSY	0.8472	0.9478	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:10	RSPPPRRSY	0.8274	0.941	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:80	RSPPPRRSY	0.8197	0.9342	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:67	RSPPPRRSY	0.8197	0.9342	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:04	RSPPPRRSY	0.8122	0.9238	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C03:14	RSYMDTEQY	0.7776	0.9806	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:46	RSPPPRRSY	0.7334	0.8822	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B14:03	SPPPRRSYM	0.7252	0.6312	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:05	RSPPPRRSY	0.716	0.9514	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C15:04	RSPPPRRSY	0.6829	0.8512	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C12:16	RSPPPRRSY	0.576	0.9588	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C03:14	RSPPPRRSY	0.3751	0.971	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B35:12	SPPPRRSYM	0.3173	0.7231	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C12:12	RSYMDTEQY	0.2333	0.9046	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C01:30	SPPPRRSYM	0.2183	0.949	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C12:12	RSPPPRRSY	0.1993	0.8924	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C01:17	SPPPRRSYM	0.1812	0.9299	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:29	SPPPRRSYM	0.1771	0.9262	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B39:10	SPPPRRSYM	0.1645	0.7976	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:13	SPPPRRSYM	0.1571	0.8342	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C12:04	RSPPPRRSY	0.1493	0.9919	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C06:03	RSPPPRRSY	0.1438	0.9894	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C04:14	SPPPRRSYM	0.0578	0.7571	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C01:17	RSPPPRRSY	0.0069	0.9438	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C04:10	SPPPRRSYM	0.0044	0.7431	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C04:07	SPPPRRSYM	0.0036	0.7748	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C01:30	RSPPPRRSY	0.0008	0.9539	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:14	RRSYMDTEQY	0.9997	0.8376	11	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:14	RRSPPPRRSY	0.9994	0.8266	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:03	RRSPPPRRSY	0.9985	0.908	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:03	RRSYMDTEQY	0.9983	0.9336	11	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:95	RRSPPPRRSY	0.9955	0.7315	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:19	RRSPPPRRSY	0.9953	0.8161	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:80	RRSPPPRRSY	0.9931	0.9517	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:67	RRSPPPRRSY	0.9931	0.9517	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:27	RRSPPPRRSY	0.9925	0.9596	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:05	RRSPPPRRSY	0.9921	0.9553	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:10	RRSPPPRRSY	0.992	0.9573	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:46	RRSPPPRRSY	0.9913	0.9091	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:46	RRSYMDTEQY	0.9749	0.8998	11	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B07:12	RSPPPRRSYM	0.916	0.6526	6	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C01:17	RSPPPRRSYM	0.8289	0.9421	6	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C15:04	RRSPPPRRSY	0.7987	0.9048	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C01:30	RSPPPRRSYM	0.7539	0.9492	6	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C12:16	RRSPPPRRSY	0.7535	0.9648	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:14	RRSPPPRRSYM	1	0.8255	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:14	RRRSPPPRRSY	0.9998	0.7649	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:95	RRSPPPRRSYM	0.999	0.6774	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:05	RRSPPPRRSYM	0.999	0.9434	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:03	RRRSPPPRRSY	0.9988	0.8378	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:03	RRSPPPRRSYM	0.9987	0.8808	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:27	RRSPPPRRSYM	0.9979	0.949	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:19	RRRSPPPRRSY	0.9969	0.7866	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:95	RRRSPPPRRSY	0.9968	0.6909	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B07:04	RRSPPPRRSYM	0.9965	0.5024	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:27	RRRSPPPRRSY	0.9958	0.9548	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:46	RRSPPPRRSYM	0.9953	0.8789	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:80	RRRSPPPRRSY	0.9951	0.9486	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:67	RRRSPPPRRSY	0.9951	0.9486	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:67	RRSPPPRRSYM	0.9949	0.9463	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:80	RRSPPPRRSYM	0.9949	0.9463	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:19	RRSPPPRRSYM	0.9939	0.7213	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:10	RRRSPPPRRSY	0.993	0.9544	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:46	RRRSPPPRRSY	0.9929	0.8807	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:10	RRSPPPRRSYM	0.9893	0.955	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:05	RRRSPPPRRSY	0.9893	0.9532	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C12:16	RRSPPPRRSYM	0.9809	0.9645	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C12:16	RRRSPPPRRSY	0.8812	0.9661	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B35:11	SPPPRRSY	0.9889	0.6354	7	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:11	SPPPRRSY	0.9823	0.7062	7	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:08	SPPPRRSY	0.9797	0.7024	7	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B35:43	SPPPRRSY	0.9686	0.7032	7	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B18:07	SPPPRRSY	0.8032	0.8229	7	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B07:13	SPPPRRSYM	0.9992	0.7596	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:39	RSYMDTEQY	0.9987	0.8426	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:27	RSYMDTEQY	0.9977	0.9373	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:34	RSYMDTEQY	0.9976	0.9183	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:33	RSYMDTEQY	0.9976	0.9183	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:125	RSYMDTEQY	0.9976	0.9183	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:135	RSYMDTEQY	0.9973	0.9184	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:35	RSYMDTEQY	0.9957	0.9237	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B57:04	RSYMDTEQY	0.9947	0.6722	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:27	RSPPPRRSY	0.9944	0.8772	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:33	RSPPPRRSY	0.9938	0.8866	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:34	RSPPPRRSY	0.9938	0.8866	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:125	RSPPPRRSY	0.9938	0.8866	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:135	RSPPPRRSY	0.9937	0.8948	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:39	RSPPPRRSY	0.9931	0.7709	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:50	RSYMDTEQY	0.9927	0.926	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B57:10	RSYMDTEQY	0.9916	0.9578	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:24	RSYMDTEQY	0.9916	0.9326	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:35	RSPPPRRSY	0.9909	0.8858	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:11	RSPPPRRSY	0.9894	0.8676	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:20	RSYMDTEQY	0.9867	0.8994	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:50	RSPPPRRSY	0.9864	0.8919	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B57:10	RSPPPRRSY	0.9831	0.9561	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:24	RSPPPRRSY	0.983	0.8979	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:12	RSYMDTEQY	0.9824	0.837	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B58:06	RSYMDTEQY	0.9815	0.8538	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:12	RSPPPRRSY	0.9809	0.8884	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:22	RSPPPRRSY	0.9807	0.7538	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B35:28	RSYMDTEQY	0.9795	0.8969	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:53	RSPPPRRSY	0.9642	0.8606	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:53	RSYMDTEQY	0.9632	0.9008	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B58:06	RSPPPRRSY	0.9584	0.6928	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B35:20	RSYMDTEQY	0.9412	0.9043	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B57:04	RSPPPRRSY	0.9353	0.7234	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C15:09	RSYMDTEQY	0.9264	0.8658	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B57:02	RSYMDTEQY	0.9224	0.8537	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-A30:01	RSPPPRRSY	0.9203	0.8426	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:01	RSPPPRRSY	0.8945	0.6944	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:17	RSPPPRRSY	0.8662	0.9541	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:54	RSYMDTEQY	0.8251	0.8833	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:02	RSPPPRRSY	0.8197	0.9342	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-A32:01	RSPPPRRSY	0.8157	0.9286	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C03:02	RSYMDTEQY	0.8096	0.9724	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B35:28	RSPPPRRSY	0.7863	0.8841	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:54	RSPPPRRSY	0.7415	0.8546	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-A32:01	RSYMDTEQY	0.7355	0.9462	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C15:09	RSPPPRRSY	0.6829	0.8512	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B48:02	RSYMDTEQY	0.6046	0.8824	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C16:04	RSYMDTEQY	0.6006	0.9754	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C16:01	RSYMDTEQY	0.554	0.9766	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C16:02	RSYMDTEQY	0.5445	0.9926	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B57:02	RSPPPRRSY	0.5371	0.8301	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B35:11	SPPPRRSYM	0.5317	0.7084	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C03:02	RSPPPRRSY	0.5136	0.9709	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C03:67	RSPPPRRSY	0.4931	0.9739	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C12:02	RSYMDTEQY	0.4853	0.9655	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C16:04	RSPPPRRSY	0.4506	0.9632	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:68	RSYMDTEQY	0.3993	0.6647	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:68	RSPPPRRSY	0.3681	0.6404	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C03:67	SPPPRRSYM	0.3617	0.9505	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C06:06	RSPPPRRSY	0.3314	0.9909	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C16:01	RSPPPRRSY	0.3251	0.9765	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B35:09	SPPPRRSYM	0.3173	0.7231	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C12:02	RSPPPRRSY	0.3028	0.9652	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C12:03	RSPPPRRSY	0.2592	0.9692	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B67:01	SPPPRRSYM	0.2316	0.5921	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C16:02	RSPPPRRSY	0.2266	0.9912	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C03:17	SPPPRRSYM	0.2021	0.945	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C02:10	RSPPPRRSY	0.1865	0.9801	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C02:02	RSPPPRRSY	0.1865	0.9801	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C06:08	RSPPPRRSY	0.1193	0.9885	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C06:17	RSPPPRRSY	0.1143	0.991	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C06:02	RSPPPRRSY	0.1143	0.991	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C02:02	RSYMDTEQY	0.094	0.969	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C02:10	RSYMDTEQY	0.094	0.969	12	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C01:02	SPPPRRSYM	0.0744	0.9314	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C03:17	RSPPPRRSY	0.027	0.9719	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:11	SPPPRRSYM	0.025	0.7251	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:08	SPPPRRSYM	0.0245	0.7284	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C14:03	RSPPPRRSY	0.0233	0.9565	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C14:02	RSPPPRRSY	0.0233	0.9565	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B35:43	SPPPRRSYM	0.0228	0.7304	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C01:02	RSPPPRRSY	0.0105	0.9451	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C04:01	SPPPRRSYM	0.0036	0.7748	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C01:03	SPPPRRSYM	0.0028	0.893	7	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C01:03	RSPPPRRSY	0.0016	0.9065	6	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:08	RRSPPPRRSY	0.9999	0.7781	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:10	RRSPPPRRSY	0.9998	0.8933	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:10	RRSYMDTEQY	0.9996	0.9065	11	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:08	RRSYMDTEQY	0.9996	0.8437	11	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:01	RRSPPPRRSY	0.9975	0.7189	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:09	RRSPPPRRSY	0.9963	0.8583	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:17	RRSPPPRRSY	0.9932	0.9645	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:02	RRSPPPRRSY	0.9931	0.9517	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:22	RRSPPPRRSY	0.9583	0.7929	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C06:08	RRSPPPRRSY	0.9438	0.9906	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C06:06	RRSPPPRRSY	0.9013	0.9919	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C03:17	RSPPPRRSYM	0.8907	0.9722	6	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:54	RRSPPPRRSY	0.8578	0.8836	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C01:03	RSPPPRRSYM	0.8303	0.9084	6	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:54	RRSYMDTEQY	0.8267	0.8711	11	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C01:02	RSPPPRRSYM	0.8075	0.9433	6	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C15:09	RRSPPPRRSY	0.7987	0.9048	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B58:06	RRSPPPRRSY	0.7905	0.8092	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:68	RRSPPPRRSY	0.7675	0.678	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:68	RRSYMDTEQY	0.7252	0.6407	11	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B58:06	RRSYMDTEQY	0.6864	0.8186	11	21
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C06:17	RRSPPPRRSY	0.6851	0.9929	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C06:02	RRSPPPRRSY	0.6851	0.9929	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C16:01	RRSPPPRRSY	0.6728	0.9802	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C16:04	RRSPPPRRSY	0.6309	0.9711	5	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:08	RRSPPPRRSYM	1	0.7555	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:06	RRSPPPRRSYM	0.9999	0.7129	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:10	RRRSPPPRRSY	0.9999	0.8776	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:08	RRRSPPPRRSY	0.9999	0.6788	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:10	RRSPPPRRSYM	0.9999	0.8792	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B27:09	RRSPPPRRSYM	0.9998	0.8117	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:01	RRSPPPRRSYM	0.9992	0.642	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:01	RRRSPPPRRSY	0.9987	0.6809	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C06:08	RRSPPPRRSYM	0.9984	0.9919	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:22	RRRSPPPRRSY	0.9966	0.777	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:17	RRRSPPPRRSY	0.9962	0.9646	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:02	RRRSPPPRRSY	0.9951	0.9486	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:02	RRSPPPRRSYM	0.9949	0.9463	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C07:22	RRSPPPRRSYM	0.9876	0.7598	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C06:06	RRSPPPRRSYM	0.987	0.9923	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B07:22	RRSPPPRRSYM	0.9634	0.5046	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C06:17	RRSPPPRRSYM	0.963	0.9937	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C06:02	RRSPPPRRSYM	0.963	0.9937	5	16
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B58:06	RRRSPPPRRSY	0.9615	0.7975	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:54	RRRSPPPRRSY	0.9501	0.8429	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-B15:68	RRRSPPPRRSY	0.8941	0.6132	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C06:17	RRRSPPPRRSY	0.8919	0.9923	4	15
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	HLA-C06:02	RRRSPPPRRSY	0.8919	0.9923	4	15

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Potential FusionNeoAntigen Information of SRSF3-DNAJC7 in HLA II

SRSF3-DNAJC7_36566760_40135654.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	457	DRB5-0103	RDDYRRRSPPPRRSY	0	15

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Fusion breakpoint peptide structures of SRSF3-DNAJC7

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
8235	RSPPPRRSYMDTEQ	SRSF3	DNAJC7	chr6	36566760	chr17	40135654	457

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of SRSF3-DNAJC7

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	8235	RSPPPRRSYMDTEQ	-7.15543	-7.26883
HLA-B14:02	3BVN	8235	RSPPPRRSYMDTEQ	-4.77435	-5.80965
HLA-B52:01	3W39	8235	RSPPPRRSYMDTEQ	-6.80875	-6.92215
HLA-B52:01	3W39	8235	RSPPPRRSYMDTEQ	-4.20386	-5.23916
HLA-A11:01	4UQ2	8235	RSPPPRRSYMDTEQ	-7.5194	-8.5547
HLA-A11:01	4UQ2	8235	RSPPPRRSYMDTEQ	-6.9601	-7.0735
HLA-A24:02	5HGA	8235	RSPPPRRSYMDTEQ	-7.52403	-7.63743
HLA-A24:02	5HGA	8235	RSPPPRRSYMDTEQ	-5.82433	-6.85963
HLA-B27:05	6PYJ	8235	RSPPPRRSYMDTEQ	-3.28285	-4.31815
HLA-B44:05	3DX8	8235	RSPPPRRSYMDTEQ	-5.91172	-6.94702
HLA-B44:05	3DX8	8235	RSPPPRRSYMDTEQ	-4.24346	-4.35686

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Vaccine Design for the FusionNeoAntigens of SRSF3-DNAJC7

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	11	21	RRSYMDTEQY	TCGCAGTTACATGGACACAGAACAGTATGA
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	12	21	RSYMDTEQY	CAGTTACATGGACACAGAACAGTATGA
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	4	15	RRRSPPPRRSY	TAGGAGGAGTCCTCCACCTCGTCGCAGTTACAT
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	5	14	RRSPPPRRS	GAGGAGTCCTCCACCTCGTCGCAGTTA
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	5	15	RRSPPPRRSY	GAGGAGTCCTCCACCTCGTCGCAGTTACAT
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	5	16	RRSPPPRRSYM	GAGGAGTCCTCCACCTCGTCGCAGTTACATGGA
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	6	15	RSPPPRRSY	GAGTCCTCCACCTCGTCGCAGTTACAT
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	6	16	RSPPPRRSYM	GAGTCCTCCACCTCGTCGCAGTTACATGGA
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	7	15	SPPPRRSY	TCCTCCACCTCGTCGCAGTTACAT
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	7	16	SPPPRRSYM	TCCTCCACCTCGTCGCAGTTACATGGA

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
SRSF3-DNAJC7	chr6	36566760	chr17	40135654	0	15	RDDYRRRSPPPRRSY	AGATGATTATCGTAGGAGGAGTCCTCCACCTCGTCGCAGTTACAT

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Information of the samples that have these potential fusion neoantigens of SRSF3-DNAJC7

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
ESCA	SRSF3-DNAJC7	chr6	36566760	ENST00000339436	chr17	40135654	ENST00000316603	TCGA-IG-A4P3

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Potential target of CAR-T therapy development for SRSF3-DNAJC7

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to SRSF3-DNAJC7

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to SRSF3-DNAJC7

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)