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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:SSBP2-NTRK1

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SSBP2-NTRK1
FusionPDB ID: 86715
FusionGDB2.0 ID: 86715
HgeneTgene
Gene symbol

SSBP2

NTRK1

Gene ID

23635

4914

Gene namesingle stranded DNA binding protein 2neurotrophic receptor tyrosine kinase 1
SynonymsHSPC116|SOSS-B2MTC|TRK|TRK1|TRKA|Trk-A|p140-TrkA
Cytomap

5q14.1

1q23.1

Type of geneprotein-codingprotein-coding
Descriptionsingle-stranded DNA-binding protein 2sequence-specific single-stranded-DNA-binding protein 2high affinity nerve growth factor receptorOncogene TRKTRK1-transforming tyrosine kinase proteingp140trkneurotrophic tyrosine kinase, receptor, type 1tropomyosin-related kinase Atyrosine kinase receptor A
Modification date2020031320200313
UniProtAcc

P81877

Main function of 5'-partner protein:

P04629

Main function of 5'-partner protein: FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:22649032, PubMed:17196528, PubMed:27445338). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. {ECO:0000250|UniProtKB:P35739, ECO:0000250|UniProtKB:Q3UFB7, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:1281417, ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:17196528, ECO:0000269|PubMed:1849459, ECO:0000269|PubMed:1850821, ECO:0000269|PubMed:22649032, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27676246, ECO:0000269|PubMed:8155326, ECO:0000269|PubMed:8325889}.; FUNCTION: [Isoform TrkA-III]: Resistant to NGF, it constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. {ECO:0000269|PubMed:15488758}.
Ensembl transtripts involved in fusion geneENST idsENST00000320672, ENST00000505980, 
ENST00000509053, ENST00000514493, 
ENST00000515395, ENST00000510060, 
ENST00000531606, ENST00000358660, 
ENST00000368196, ENST00000392302, 
ENST00000524377, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 13 X 6=93625 X 24 X 13=7800
# samples 1433
** MAII scorelog2(14/936*10)=-2.74108170263844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(33/7800*10)=-4.56293619439116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: SSBP2 [Title/Abstract] AND NTRK1 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: SSBP2 [Title/Abstract] AND NTRK1 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SSBP2(80742687)-NTRK1(156845312), # samples:3
Anticipated loss of major functional domain due to fusion event.SSBP2-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SSBP2-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SSBP2-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SSBP2-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNTRK1

GO:0006468

protein phosphorylation

15488758

TgeneNTRK1

GO:0008285

negative regulation of cell proliferation

15488758

TgeneNTRK1

GO:0010976

positive regulation of neuron projection development

15488758

TgeneNTRK1

GO:0018108

peptidyl-tyrosine phosphorylation

2927393

TgeneNTRK1

GO:0043547

positive regulation of GTPase activity

15488758

TgeneNTRK1

GO:0046579

positive regulation of Ras protein signal transduction

15488758

TgeneNTRK1

GO:0046777

protein autophosphorylation

15488758

TgeneNTRK1

GO:0048011

neurotrophin TRK receptor signaling pathway

15488758

TgeneNTRK1

GO:0051092

positive regulation of NF-kappaB transcription factor activity

15488758

TgeneNTRK1

GO:0070374

positive regulation of ERK1 and ERK2 cascade

15488758

TgeneNTRK1

GO:1904646

cellular response to amyloid-beta

11927634



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:80742687/chr1:156845312)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across SSBP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NTRK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000320672SSBP2chr580742687-ENST00000392302NTRK1chr1156845312+21789892112025604
ENST00000320672SSBP2chr580742687-ENST00000368196NTRK1chr1156845312+22349892112025604
ENST00000320672SSBP2chr580742687-ENST00000524377NTRK1chr1156845312+20269892112025605
ENST00000320672SSBP2chr580742687-ENST00000358660NTRK1chr1156845312+21049892112034607
ENST00000509053SSBP2chr580742687-ENST00000392302NTRK1chr1156845312+188369461730574
ENST00000509053SSBP2chr580742687-ENST00000368196NTRK1chr1156845312+193969461730574
ENST00000509053SSBP2chr580742687-ENST00000524377NTRK1chr1156845312+173169461730574
ENST00000509053SSBP2chr580742687-ENST00000358660NTRK1chr1156845312+180969461739577
ENST00000514493SSBP2chr580742687-ENST00000392302NTRK1chr1156845312+20858962081932574
ENST00000514493SSBP2chr580742687-ENST00000368196NTRK1chr1156845312+21418962081932574
ENST00000514493SSBP2chr580742687-ENST00000524377NTRK1chr1156845312+19338962081932575
ENST00000514493SSBP2chr580742687-ENST00000358660NTRK1chr1156845312+20118962081941577
ENST00000505980SSBP2chr580742687-ENST00000392302NTRK1chr1156845312+191272351759584
ENST00000505980SSBP2chr580742687-ENST00000368196NTRK1chr1156845312+196872351759584
ENST00000505980SSBP2chr580742687-ENST00000524377NTRK1chr1156845312+176072351759585
ENST00000505980SSBP2chr580742687-ENST00000358660NTRK1chr1156845312+183872351768587
ENST00000515395SSBP2chr580742687-ENST00000392302NTRK1chr1156845312+1956767551803582
ENST00000515395SSBP2chr580742687-ENST00000368196NTRK1chr1156845312+2012767551803582
ENST00000515395SSBP2chr580742687-ENST00000524377NTRK1chr1156845312+1804767551803583
ENST00000515395SSBP2chr580742687-ENST00000358660NTRK1chr1156845312+1882767551812585
ENST00000320672SSBP2chr580742686-ENST00000392302NTRK1chr1156845311+21789892112025604
ENST00000320672SSBP2chr580742686-ENST00000368196NTRK1chr1156845311+22349892112025604
ENST00000320672SSBP2chr580742686-ENST00000524377NTRK1chr1156845311+20269892112025605
ENST00000320672SSBP2chr580742686-ENST00000358660NTRK1chr1156845311+21049892112034607
ENST00000509053SSBP2chr580742686-ENST00000392302NTRK1chr1156845311+188369461730574
ENST00000509053SSBP2chr580742686-ENST00000368196NTRK1chr1156845311+193969461730574
ENST00000509053SSBP2chr580742686-ENST00000524377NTRK1chr1156845311+173169461730574
ENST00000509053SSBP2chr580742686-ENST00000358660NTRK1chr1156845311+180969461739577
ENST00000514493SSBP2chr580742686-ENST00000392302NTRK1chr1156845311+20858962081932574
ENST00000514493SSBP2chr580742686-ENST00000368196NTRK1chr1156845311+21418962081932574
ENST00000514493SSBP2chr580742686-ENST00000524377NTRK1chr1156845311+19338962081932575
ENST00000514493SSBP2chr580742686-ENST00000358660NTRK1chr1156845311+20118962081941577
ENST00000505980SSBP2chr580742686-ENST00000392302NTRK1chr1156845311+191272351759584
ENST00000505980SSBP2chr580742686-ENST00000368196NTRK1chr1156845311+196872351759584
ENST00000505980SSBP2chr580742686-ENST00000524377NTRK1chr1156845311+176072351759585
ENST00000505980SSBP2chr580742686-ENST00000358660NTRK1chr1156845311+183872351768587
ENST00000515395SSBP2chr580742686-ENST00000392302NTRK1chr1156845311+1956767551803582
ENST00000515395SSBP2chr580742686-ENST00000368196NTRK1chr1156845311+2012767551803582
ENST00000515395SSBP2chr580742686-ENST00000524377NTRK1chr1156845311+1804767551803583
ENST00000515395SSBP2chr580742686-ENST00000358660NTRK1chr1156845311+1882767551812585

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000320672ENST00000392302SSBP2chr580742687-NTRK1chr1156845312+0.047603390.9523966
ENST00000320672ENST00000368196SSBP2chr580742687-NTRK1chr1156845312+0.0447570530.95524293
ENST00000320672ENST00000524377SSBP2chr580742687-NTRK1chr1156845312+0.0446454470.9553545
ENST00000320672ENST00000358660SSBP2chr580742687-NTRK1chr1156845312+0.045932430.9540676
ENST00000509053ENST00000392302SSBP2chr580742687-NTRK1chr1156845312+0.0573405030.9426595
ENST00000509053ENST00000368196SSBP2chr580742687-NTRK1chr1156845312+0.0526734480.94732654
ENST00000509053ENST00000524377SSBP2chr580742687-NTRK1chr1156845312+0.0468525140.9531475
ENST00000509053ENST00000358660SSBP2chr580742687-NTRK1chr1156845312+0.0513476580.9486523
ENST00000514493ENST00000392302SSBP2chr580742687-NTRK1chr1156845312+0.0588138920.9411861
ENST00000514493ENST00000368196SSBP2chr580742687-NTRK1chr1156845312+0.0566217270.94337827
ENST00000514493ENST00000524377SSBP2chr580742687-NTRK1chr1156845312+0.058174580.9418254
ENST00000514493ENST00000358660SSBP2chr580742687-NTRK1chr1156845312+0.062675520.93732446
ENST00000505980ENST00000392302SSBP2chr580742687-NTRK1chr1156845312+0.0375613350.9624387
ENST00000505980ENST00000368196SSBP2chr580742687-NTRK1chr1156845312+0.0343969650.96560305
ENST00000505980ENST00000524377SSBP2chr580742687-NTRK1chr1156845312+0.0302535520.9697464
ENST00000505980ENST00000358660SSBP2chr580742687-NTRK1chr1156845312+0.030767160.9692329
ENST00000515395ENST00000392302SSBP2chr580742687-NTRK1chr1156845312+0.0518908540.94810915
ENST00000515395ENST00000368196SSBP2chr580742687-NTRK1chr1156845312+0.048567970.95143205
ENST00000515395ENST00000524377SSBP2chr580742687-NTRK1chr1156845312+0.0477216280.9522784
ENST00000515395ENST00000358660SSBP2chr580742687-NTRK1chr1156845312+0.0521758650.9478242
ENST00000320672ENST00000392302SSBP2chr580742686-NTRK1chr1156845311+0.047603390.9523966
ENST00000320672ENST00000368196SSBP2chr580742686-NTRK1chr1156845311+0.0447570530.95524293
ENST00000320672ENST00000524377SSBP2chr580742686-NTRK1chr1156845311+0.0446454470.9553545
ENST00000320672ENST00000358660SSBP2chr580742686-NTRK1chr1156845311+0.045932430.9540676
ENST00000509053ENST00000392302SSBP2chr580742686-NTRK1chr1156845311+0.0573405030.9426595
ENST00000509053ENST00000368196SSBP2chr580742686-NTRK1chr1156845311+0.0526734480.94732654
ENST00000509053ENST00000524377SSBP2chr580742686-NTRK1chr1156845311+0.0468525140.9531475
ENST00000509053ENST00000358660SSBP2chr580742686-NTRK1chr1156845311+0.0513476580.9486523
ENST00000514493ENST00000392302SSBP2chr580742686-NTRK1chr1156845311+0.0588138920.9411861
ENST00000514493ENST00000368196SSBP2chr580742686-NTRK1chr1156845311+0.0566217270.94337827
ENST00000514493ENST00000524377SSBP2chr580742686-NTRK1chr1156845311+0.058174580.9418254
ENST00000514493ENST00000358660SSBP2chr580742686-NTRK1chr1156845311+0.062675520.93732446
ENST00000505980ENST00000392302SSBP2chr580742686-NTRK1chr1156845311+0.0375613350.9624387
ENST00000505980ENST00000368196SSBP2chr580742686-NTRK1chr1156845311+0.0343969650.96560305
ENST00000505980ENST00000524377SSBP2chr580742686-NTRK1chr1156845311+0.0302535520.9697464
ENST00000505980ENST00000358660SSBP2chr580742686-NTRK1chr1156845311+0.030767160.9692329
ENST00000515395ENST00000392302SSBP2chr580742686-NTRK1chr1156845311+0.0518908540.94810915
ENST00000515395ENST00000368196SSBP2chr580742686-NTRK1chr1156845311+0.048567970.95143205
ENST00000515395ENST00000524377SSBP2chr580742686-NTRK1chr1156845311+0.0477216280.9522784
ENST00000515395ENST00000358660SSBP2chr580742686-NTRK1chr1156845311+0.0521758650.9478242

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for SSBP2-NTRK1

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
SSBP2chr580742686NTRK1chr1156845311694229GGPPGTPIMPSPAGPAVLAPEDGLAM
SSBP2chr580742686NTRK1chr1156845311723239GGPPGTPIMPSPAGPAVLAPEDGLAM
SSBP2chr580742686NTRK1chr1156845311767237GGPPGTPIMPSPAGPAVLAPEDGLAM
SSBP2chr580742686NTRK1chr1156845311896229GGPPGTPIMPSPAGPAVLAPEDGLAM
SSBP2chr580742686NTRK1chr1156845311989259GGPPGTPIMPSPAGPAVLAPEDGLAM
SSBP2chr580742687NTRK1chr1156845312694229GGPPGTPIMPSPAGPAVLAPEDGLAM
SSBP2chr580742687NTRK1chr1156845312723239GGPPGTPIMPSPAGPAVLAPEDGLAM
SSBP2chr580742687NTRK1chr1156845312767237GGPPGTPIMPSPAGPAVLAPEDGLAM
SSBP2chr580742687NTRK1chr1156845312896229GGPPGTPIMPSPAGPAVLAPEDGLAM
SSBP2chr580742687NTRK1chr1156845312989259GGPPGTPIMPSPAGPAVLAPEDGLAM

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Potential FusionNeoAntigen Information of SSBP2-NTRK1 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
SSBP2-NTRK1_80742686_156845311.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
SSBP2-NTRK1chr580742686chr1156845311989HLA-B07:02SPAGPAVL0.99980.55271018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:01MPSPAGPA0.99780.6848816
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:01MPSPAGPA0.99680.5227816
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:03SPAGPAVL0.9720.89411018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:02SPAGPAVL0.90610.97051018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:04SPAGPAVL0.90610.97051018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B81:01SPAGPAVL0.87780.61241018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B82:01SPAGPAVL0.68720.51891018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:01MPSPAGPAV0.99890.8231817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:02MPSPAGPAV0.99730.9337817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:01MPSPAGPAV0.99720.6495817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:03MPSPAGPAV0.99710.8834817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:04MPSPAGPAV0.99660.9741817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:02MPSPAGPAV0.99660.9741817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B07:02SPAGPAVLA0.99660.63361019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B07:05SPAGPAVLA0.99640.59421019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:01MPSPAGPAV0.99230.9259817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B39:24MPSPAGPAV0.99140.8994817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:01MPSPAGPAV0.9910.9451817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B39:06MPSPAGPAV0.99090.9808817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:08MPSPAGPAV0.98730.7797817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:05MPSPAGPAV0.98340.761817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:01SPAGPAVLA0.96980.59381019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B15:10MPSPAGPAV0.96880.7373817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B53:01MPSPAGPAV0.95630.6726817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B15:37MPSPAGPAV0.94850.7963817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B08:09MPSPAGPAV0.91510.9101817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B39:01MPSPAGPAV0.90980.9802817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:01TPIMPSPAG0.89820.7523514
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:04SPAGPAVLA0.81680.9241019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:02SPAGPAVLA0.81680.9241019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:01TPIMPSPAG0.70560.5389514
SSBP2-NTRK1chr580742686chr1156845311989HLA-B82:01MPSPAGPAV0.6260.7448817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B81:01MPSPAGPAV0.55370.8672817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B81:01SPAGPAVLA0.29460.81061019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B82:01SPAGPAVLA0.25080.69291019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B07:10MPSPAGPAVL0.99940.5419818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:03MPSPAGPAVL0.99540.9613818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:01MPSPAGPAVL0.99380.9637818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:01MPSPAGPAVL0.99160.5904818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:08MPSPAGPAVL0.98140.9355818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:04MPSPAGPAVL0.98110.9846818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:02MPSPAGPAVL0.98110.9846818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:05MPSPAGPAVL0.97860.8285818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B53:01MPSPAGPAVL0.97120.641818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:01TPIMPSPAGP0.94340.786515
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:01SPAGPAVLAP0.94140.72851020
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:02MPSPAGPAVL0.93720.6974818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:01SPAGPAVLAP0.92520.54951020
SSBP2-NTRK1chr580742686chr1156845311989HLA-B81:01MPSPAGPAVL0.91150.654818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:01IMPSPAGPAV0.90440.548717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:01IMPSPAGPAV0.90320.9585717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:02IMPSPAGPAV0.8860.8647717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:01IMPSPAGPAV0.86610.7799717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:01MPSPAGPAVL0.85510.6907818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:02IMPSPAGPAV0.82940.9821717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:04IMPSPAGPAV0.82940.9821717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B81:01IMPSPAGPAV0.81510.8032717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:03IMPSPAGPAV0.76960.892717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B82:01MPSPAGPAVL0.74760.5989818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B82:01IMPSPAGPAV0.60450.7472717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:01MPSPAGPAVLA0.99830.7033819
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:03MPSPAGPAVLA0.99610.7392819
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:01TPIMPSPAGPA0.99610.7902516
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:01MPSPAGPAVLA0.99550.5292819
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:01TPIMPSPAGPA0.99490.6393516
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:04MPSPAGPAVLA0.98660.9697819
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:02MPSPAGPAVLA0.98660.9697819
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:03IMPSPAGPAVL0.98360.9645718
SSBP2-NTRK1chr580742686chr1156845311989HLA-B07:12SPAGPAVL0.99940.63081018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B54:01MPSPAGPA0.99890.9242816
SSBP2-NTRK1chr580742686chr1156845311989HLA-B07:04SPAGPAVL0.99340.51451018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B78:01MPSPAGPA0.99290.9692816
SSBP2-NTRK1chr580742686chr1156845311989HLA-C01:17SPAGPAVL0.97610.95791018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B42:02SPAGPAVL0.9730.52061018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B42:01SPAGPAVL0.96760.51671018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:04SPAGPAVL0.95840.58641018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B39:10SPAGPAVL0.9220.96291018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:12SPAGPAVL0.90610.97051018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B54:01MPSPAGPAV0.99940.9523817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:04MPSPAGPAV0.99680.8521817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:12MPSPAGPAV0.99660.9741817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B78:01MPSPAGPAV0.99480.9798817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:07MPSPAGPAV0.99090.9908817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B07:12SPAGPAVLA0.98810.71091019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:08MPSPAGPAV0.9860.7926817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B54:01SPAGPAVLA0.98420.7841019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B42:02MPSPAGPAV0.95930.8258817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B39:09MPSPAGPAV0.94230.968817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B42:01MPSPAGPAV0.9410.8256817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B39:10MPSPAGPAV0.93890.985817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B07:04SPAGPAVLA0.84610.53821019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:04SPAGPAVLA0.840.73621019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:12SPAGPAVLA0.81680.9241019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B14:03MPSPAGPAV0.80080.9495817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B39:05MPSPAGPAV0.78180.9774817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B78:01SPAGPAVLA0.7370.69021019
SSBP2-NTRK1chr580742686chr1156845311989HLA-C01:17PSPAGPAVL0.53380.9606918
SSBP2-NTRK1chr580742686chr1156845311989HLA-C01:30PSPAGPAVL0.44330.9709918
SSBP2-NTRK1chr580742686chr1156845311989HLA-B39:10SPAGPAVLA0.40390.93541019
SSBP2-NTRK1chr580742686chr1156845311989HLA-C04:07MPSPAGPAV0.0070.9768817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B07:12MPSPAGPAVL0.99920.6653818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B07:04MPSPAGPAVL0.99250.5184818
SSBP2-NTRK1chr580742686chr1156845311989HLA-C01:17MPSPAGPAVL0.98890.9729818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:04MPSPAGPAVL0.98770.6601818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B54:01SPAGPAVLAP0.98630.88611020
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:12MPSPAGPAVL0.98110.9846818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B39:10MPSPAGPAVL0.97550.9898818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B42:02MPSPAGPAVL0.97350.8913818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B54:01MPSPAGPAVL0.97210.753818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B42:01MPSPAGPAVL0.96690.8872818
SSBP2-NTRK1chr580742686chr1156845311989HLA-C01:30MPSPAGPAVL0.96070.9657818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B54:01IMPSPAGPAV0.95850.9369717
SSBP2-NTRK1chr580742686chr1156845311989HLA-C01:30IMPSPAGPAV0.9550.9813717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B78:01IMPSPAGPAV0.95350.9766717
SSBP2-NTRK1chr580742686chr1156845311989HLA-A02:07IMPSPAGPAV0.91870.7567717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B78:01MPSPAGPAVL0.88860.8608818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:08IMPSPAGPAV0.86990.8983717
SSBP2-NTRK1chr580742686chr1156845311989HLA-C01:17IMPSPAGPAV0.8670.9809717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:12IMPSPAGPAV0.82940.9821717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:08MPSPAGPAVL0.78890.7015818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:04IMPSPAGPAV0.73850.861717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B42:01IMPSPAGPAV0.62690.9429717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B39:10IMPSPAGPAV0.37920.9913717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B54:01MPSPAGPAVLA0.99970.9291819
SSBP2-NTRK1chr580742686chr1156845311989HLA-C01:17IMPSPAGPAVL0.99830.985718
SSBP2-NTRK1chr580742686chr1156845311989HLA-B54:01TPIMPSPAGPA0.9980.9296516
SSBP2-NTRK1chr580742686chr1156845311989HLA-C01:30IMPSPAGPAVL0.99550.9843718
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:04MPSPAGPAVLA0.99420.8488819
SSBP2-NTRK1chr580742686chr1156845311989HLA-B78:01MPSPAGPAVLA0.98970.9632819
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:12MPSPAGPAVLA0.98660.9697819
SSBP2-NTRK1chr580742686chr1156845311989HLA-B39:10MPSPAGPAVLA0.96780.9856819
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:04IMPSPAGPAVL0.94390.7597718
SSBP2-NTRK1chr580742686chr1156845311989HLA-B07:09SPAGPAVL0.99980.56491018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B07:22SPAGPAVL0.99980.55271018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:02MPSPAGPA0.99770.7276816
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:05MPSPAGPA0.99670.8569816
SSBP2-NTRK1chr580742686chr1156845311989HLA-B78:02MPSPAGPA0.99050.9718816
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:22SPAGPAVL0.97950.57451018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:04SPAGPAVL0.9770.55691018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:05SPAGPAVL0.9730.5311018
SSBP2-NTRK1chr580742686chr1156845311989HLA-C01:02SPAGPAVL0.96120.95691018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:02SPAGPAVL0.95840.58641018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:09SPAGPAVL0.90610.97051018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B67:01SPAGPAVL0.88390.94121018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B82:02SPAGPAVL0.68720.51891018
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:22MPSPAGPAV0.99870.7356817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:02MPSPAGPAV0.99820.8689817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:04MPSPAGPAV0.99720.8052817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B59:01MPSPAGPAV0.99690.8348817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:05MPSPAGPAV0.99690.9152817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:13MPSPAGPAV0.99690.8867817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:02MPSPAGPAV0.99680.8521817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:09MPSPAGPAV0.99660.9741817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B07:22SPAGPAVLA0.99660.63361019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B78:02MPSPAGPAV0.99450.9793817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:23MPSPAGPAV0.99310.926817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:09MPSPAGPAV0.99310.8828817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:77MPSPAGPAV0.99230.9259817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:13MPSPAGPAV0.99050.8426817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:14MPSPAGPAV0.99040.8977817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:20MPSPAGPAV0.99020.9435817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:21MPSPAGPAV0.98980.9489817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:06MPSPAGPAV0.9870.8691817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:17MPSPAGPAV0.98160.8639817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:30MPSPAGPAV0.98160.8639817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:11MPSPAGPAV0.97540.9381817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:29MPSPAGPAV0.97420.7654817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B67:01MPSPAGPAV0.97010.9807817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:24MPSPAGPAV0.93840.8939817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:02SPAGPAVLA0.92570.59881019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:05SPAGPAVLA0.8920.50261019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:02TPIMPSPAG0.88170.7898514
SSBP2-NTRK1chr580742686chr1156845311989HLA-A69:01MPSPAGPAV0.88030.8095817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B59:01SPAGPAVLA0.87650.61151019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B07:26MPSPAGPAV0.87020.5594817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B15:09MPSPAGPAV0.86390.948817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B53:02MPSPAGPAV0.8490.7715817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:02SPAGPAVLA0.840.73621019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B39:11MPSPAGPAV0.82840.9572817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:09SPAGPAVLA0.81680.9241019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:05MPSPAGPAV0.81330.5297817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:04SPAGPAVLA0.77260.67851019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B78:02SPAGPAVLA0.72750.74861019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B82:02MPSPAGPAV0.6260.7448817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B67:01SPAGPAVLA0.55110.92581019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:05TPIMPSPAG0.53020.7974514
SSBP2-NTRK1chr580742686chr1156845311989HLA-C01:02PSPAGPAVL0.4740.9596918
SSBP2-NTRK1chr580742686chr1156845311989HLA-C01:03PSPAGPAVL0.37170.9579918
SSBP2-NTRK1chr580742686chr1156845311989HLA-B18:07MPSPAGPAV0.30140.8668817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B82:02SPAGPAVLA0.25080.69291019
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:43MPSPAGPAV0.02540.9189817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B15:08MPSPAGPAV0.01510.9171817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B15:11MPSPAGPAV0.01250.9143817
SSBP2-NTRK1chr580742686chr1156845311989HLA-C04:01MPSPAGPAV0.0070.9768817
SSBP2-NTRK1chr580742686chr1156845311989HLA-B07:09MPSPAGPAVL0.99940.5332818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:04MPSPAGPAVL0.99690.6372818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:13MPSPAGPAVL0.99530.9617818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B59:01MPSPAGPAVL0.9950.6421818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:77MPSPAGPAVL0.99380.9637818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:23MPSPAGPAVL0.99330.9655818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:02MPSPAGPAVL0.99270.6347818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:22MPSPAGPAVL0.98980.6484818
SSBP2-NTRK1chr580742686chr1156845311989HLA-C01:02MPSPAGPAVL0.98780.9722818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:02MPSPAGPAVL0.98770.6601818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:09MPSPAGPAVL0.98110.9846818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B67:01MPSPAGPAVL0.97980.9883818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:30MPSPAGPAVL0.97970.9216818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:17MPSPAGPAVL0.97970.9216818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:11MPSPAGPAVL0.97290.9563818
SSBP2-NTRK1chr580742686chr1156845311989HLA-C01:03MPSPAGPAVL0.96760.9711818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:02SPAGPAVLAP0.96140.77811020
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:05MPSPAGPAVL0.96110.6213818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B07:26MPSPAGPAVL0.94510.5062818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:29IMPSPAGPAV0.94380.8501717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B15:08MPSPAGPAVL0.94010.9101818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B15:11MPSPAGPAVL0.93760.8979818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B78:02IMPSPAGPAV0.93690.9761717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:29MPSPAGPAVL0.93550.6231818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:43MPSPAGPAVL0.93180.9122818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:05MPSPAGPAVL0.91750.523818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:14IMPSPAGPAV0.90980.9364717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:22IMPSPAGPAV0.89850.7098717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:13IMPSPAGPAV0.89740.9182717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:05IMPSPAGPAV0.89330.9336717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:09IMPSPAGPAV0.89070.8949717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B78:02MPSPAGPAVL0.88310.955818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:09MPSPAGPAVL0.88030.8029818
SSBP2-NTRK1chr580742686chr1156845311989HLA-C01:02IMPSPAGPAV0.87940.9797717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:24MPSPAGPAVL0.87920.9504818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:05IMPSPAGPAV0.87570.5715717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:06MPSPAGPAVL0.87510.6557818
SSBP2-NTRK1chr580742686chr1156845311989HLA-C01:03IMPSPAGPAV0.87130.9911717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:13MPSPAGPAVL0.8620.6344818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:14MPSPAGPAVL0.84710.6143818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:02IMPSPAGPAV0.83350.8115717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:09IMPSPAGPAV0.82940.9821717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B59:01IMPSPAGPAV0.82030.8403717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:04IMPSPAGPAV0.81470.8724717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B07:26IMPSPAGPAV0.81290.5338717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:21IMPSPAGPAV0.79950.9633717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B51:21MPSPAGPAVL0.78050.8046818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B53:02MPSPAGPAVL0.76740.7113818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B82:02MPSPAGPAVL0.74760.5989818
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:02IMPSPAGPAV0.73850.861717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B82:02IMPSPAGPAV0.60450.7472717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B67:01IMPSPAGPAV0.46890.9839717
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:02MPSPAGPAVLA0.99920.8141819
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:04MPSPAGPAVLA0.99720.7972819
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:22MPSPAGPAVLA0.99710.703819
SSBP2-NTRK1chr580742686chr1156845311989HLA-B55:02TPIMPSPAGPA0.99680.8148516
SSBP2-NTRK1chr580742686chr1156845311989HLA-C01:02IMPSPAGPAVL0.99650.9842718
SSBP2-NTRK1chr580742686chr1156845311989HLA-C01:03IMPSPAGPAVL0.99560.9857718
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:05MPSPAGPAVLA0.99450.8894819
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:02MPSPAGPAVLA0.99420.8488819
SSBP2-NTRK1chr580742686chr1156845311989HLA-B59:01MPSPAGPAVLA0.99170.856819
SSBP2-NTRK1chr580742686chr1156845311989HLA-B35:09MPSPAGPAVLA0.98660.9697819
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:05TPIMPSPAGPA0.98590.8575516
SSBP2-NTRK1chr580742686chr1156845311989HLA-B67:01MPSPAGPAVLA0.98510.9826819
SSBP2-NTRK1chr580742686chr1156845311989HLA-B78:02MPSPAGPAVLA0.98150.9667819
SSBP2-NTRK1chr580742686chr1156845311989HLA-B56:02IMPSPAGPAVL0.94390.7597718
SSBP2-NTRK1chr580742686chr1156845311989HLA-B67:01IMPSPAGPAVL0.8890.9926718

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Potential FusionNeoAntigen Information of SSBP2-NTRK1 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
SSBP2-NTRK1_80742686_156845311.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
SSBP2-NTRK1chr580742686chr1156845311989DRB1-0906GTPIMPSPAGPAVLA419
SSBP2-NTRK1chr580742686chr1156845311989DRB1-0906PGTPIMPSPAGPAVL318
SSBP2-NTRK1chr580742686chr1156845311989DRB1-0906PPGTPIMPSPAGPAV217

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Fusion breakpoint peptide structures of SSBP2-NTRK1

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
6699PIMPSPAGPAVLAPSSBP2NTRK1chr580742686chr1156845311989

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of SSBP2-NTRK1

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN6699PIMPSPAGPAVLAP-7.9962-8.1096
HLA-B14:023BVN6699PIMPSPAGPAVLAP-5.70842-6.74372
HLA-B52:013W396699PIMPSPAGPAVLAP-6.83737-6.95077
HLA-B52:013W396699PIMPSPAGPAVLAP-4.4836-5.5189
HLA-A11:014UQ26699PIMPSPAGPAVLAP-10.0067-10.1201
HLA-A11:014UQ26699PIMPSPAGPAVLAP-9.03915-10.0745
HLA-A24:025HGA6699PIMPSPAGPAVLAP-6.56204-6.67544
HLA-A24:025HGA6699PIMPSPAGPAVLAP-5.42271-6.45801
HLA-B44:053DX86699PIMPSPAGPAVLAP-7.85648-8.89178
HLA-B44:053DX86699PIMPSPAGPAVLAP-5.3978-5.5112
HLA-A02:016TDR6699PIMPSPAGPAVLAP-3.37154-4.40684

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Vaccine Design for the FusionNeoAntigens of SSBP2-NTRK1

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
SSBP2-NTRK1chr580742686chr11568453111018SPAGPAVLGTCCAGCAGGCCCGGCTGTGCTGG
SSBP2-NTRK1chr580742686chr11568453111019SPAGPAVLAGTCCAGCAGGCCCGGCTGTGCTGGCTC
SSBP2-NTRK1chr580742686chr11568453111020SPAGPAVLAPGTCCAGCAGGCCCGGCTGTGCTGGCTCCAG
SSBP2-NTRK1chr580742686chr1156845311514TPIMPSPAGCACCCATCATGCCTAGTCCAGCAGGCC
SSBP2-NTRK1chr580742686chr1156845311515TPIMPSPAGPCACCCATCATGCCTAGTCCAGCAGGCCCGG
SSBP2-NTRK1chr580742686chr1156845311516TPIMPSPAGPACACCCATCATGCCTAGTCCAGCAGGCCCGGCTG
SSBP2-NTRK1chr580742686chr1156845311717IMPSPAGPAVTCATGCCTAGTCCAGCAGGCCCGGCTGTGC
SSBP2-NTRK1chr580742686chr1156845311718IMPSPAGPAVLTCATGCCTAGTCCAGCAGGCCCGGCTGTGCTGG
SSBP2-NTRK1chr580742686chr1156845311816MPSPAGPATGCCTAGTCCAGCAGGCCCGGCTG
SSBP2-NTRK1chr580742686chr1156845311817MPSPAGPAVTGCCTAGTCCAGCAGGCCCGGCTGTGC
SSBP2-NTRK1chr580742686chr1156845311818MPSPAGPAVLTGCCTAGTCCAGCAGGCCCGGCTGTGCTGG
SSBP2-NTRK1chr580742686chr1156845311819MPSPAGPAVLATGCCTAGTCCAGCAGGCCCGGCTGTGCTGGCTC
SSBP2-NTRK1chr580742686chr1156845311918PSPAGPAVLCTAGTCCAGCAGGCCCGGCTGTGCTGG

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
SSBP2-NTRK1chr580742686chr1156845311217PPGTPIMPSPAGPAVCACCAGGAACACCCATCATGCCTAGTCCAGCAGGCCCGGCTGTGC
SSBP2-NTRK1chr580742686chr1156845311318PGTPIMPSPAGPAVLCAGGAACACCCATCATGCCTAGTCCAGCAGGCCCGGCTGTGCTGG
SSBP2-NTRK1chr580742686chr1156845311419GTPIMPSPAGPAVLAGAACACCCATCATGCCTAGTCCAGCAGGCCCGGCTGTGCTGGCTC

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Information of the samples that have these potential fusion neoantigens of SSBP2-NTRK1

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
THCASSBP2-NTRK1chr580742686ENST00000320672chr1156845311ENST00000358660TCGA-CE-A3MD

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Potential target of CAR-T therapy development for SSBP2-NTRK1

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNTRK1chr5:80742686chr1:156845311ENST000003923021017424_4390761.0TransmembraneHelical
TgeneNTRK1chr5:80742687chr1:156845312ENST000003923021017424_4390761.0TransmembraneHelical

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to SSBP2-NTRK1

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SSBP2-NTRK1

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSSBP2C0005586Bipolar Disorder1CTD_human
HgeneSSBP2C0005587Depression, Bipolar1CTD_human
HgeneSSBP2C0024713Manic Disorder1CTD_human
HgeneSSBP2C0033578Prostatic Neoplasms1CTD_human
HgeneSSBP2C0338831Manic1CTD_human
HgeneSSBP2C0376358Malignant neoplasm of prostate1CTD_human
TgeneNTRK1C0020074HSAN Type IV17CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneNTRK1C0238463Papillary thyroid carcinoma3ORPHANET
TgeneNTRK1C0002768Congenital Pain Insensitivity1ORPHANET
TgeneNTRK1C0005586Bipolar Disorder1CTD_human
TgeneNTRK1C0005587Depression, Bipolar1CTD_human
TgeneNTRK1C0017638Glioma1CTD_human
TgeneNTRK1C0020075Hereditary Sensory Autonomic Neuropathy, Type 51CTD_human;ORPHANET
TgeneNTRK1C0024713Manic Disorder1CTD_human
TgeneNTRK1C0027796Neuralgia1CTD_human
TgeneNTRK1C0027819Neuroblastoma1CTD_human
TgeneNTRK1C0033958Psychosis, Brief Reactive1CTD_human
TgeneNTRK1C0033975Psychotic Disorders1CTD_human
TgeneNTRK1C0036337Schizoaffective Disorder1CTD_human
TgeneNTRK1C0036341Schizophrenia1CTD_human
TgeneNTRK1C0036358Schizophreniform Disorders1CTD_human
TgeneNTRK1C0038870Neuralgia, Supraorbital1CTD_human
TgeneNTRK1C0042656Neuralgia, Vidian1CTD_human
TgeneNTRK1C0234247Neuralgia, Atypical1CTD_human
TgeneNTRK1C0234249Neuralgia, Stump1CTD_human
TgeneNTRK1C0259783mixed gliomas1CTD_human
TgeneNTRK1C0273115Lung Injury1CTD_human
TgeneNTRK1C0338831Manic1CTD_human
TgeneNTRK1C0423711Neuralgia, Perineal1CTD_human
TgeneNTRK1C0423712Neuralgia, Iliohypogastric Nerve1CTD_human
TgeneNTRK1C0555198Malignant Glioma1CTD_human
TgeneNTRK1C0598589Inherited neuropathies1GENOMICS_ENGLAND
TgeneNTRK1C0751371Neuralgia, Ilioinguinal1CTD_human
TgeneNTRK1C0751372Nerve Pain1CTD_human
TgeneNTRK1C0751373Paroxysmal Nerve Pain1CTD_human
TgeneNTRK1C0752347Lewy Body Disease1CTD_human
TgeneNTRK1C1833921Familial medullary thyroid carcinoma1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneNTRK1C2350344Chronic Lung Injury1CTD_human