Home

Download

Statistics

Examples

Help

Contact

Fusion Protein:ST7-CAV1

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ST7-CAV1
	FusionPDB ID: 87017
	FusionGDB2.0 ID: 87017
		Hgene	Tgene
	Gene symbol	ST7	CAV1
	Gene ID	93655	857
	Gene name	ST7 overlapping transcript 3	caveolin 1
	Synonyms	NCRNA00026\|ST7\|ST7OT3	BSCL3\|CGL3\|LCCNS\|MSTP085\|PPH3\|VIP21
	Cytomap	7q31.2	7q31.2
	Type of gene	ncRNA	protein-coding
	Description	ST7 overlapping transcript 3 (non-coding RNA)ST7 overlapping transcript 3 (non-protein coding)suppression of tumorigenicity 7	caveolin-1caveolin 1, caveolae protein, 22kDacell growth-inhibiting protein 32
	Modification date	20200313	20200329
	UniProtAcc	.	Q03135 Main function of 5'-partner protein: FUNCTION: May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). {ECO:0000250\|UniProtKB:P49817, ECO:0000269\|PubMed:11751885, ECO:0000269\|PubMed:17287217, ECO:0000269\|PubMed:19262564, ECO:0000269\|PubMed:25893292}.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000265437, ENST00000323984, ENST00000393446, ENST00000393449, ENST00000393451, ENST00000393443, ENST00000393444, ENST00000393447, ENST00000422922, ENST00000432298, ENST00000465133, ENST00000487459,	ENST00000393468, ENST00000341049, ENST00000393467, ENST00000393470, ENST00000405348,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	17 X 11 X 9=1683	11 X 9 X 7=693
	# samples	23	14
	** MAII score	log2(23/1683*10)=-2.87132941038557 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/693*10)=-2.30742852519225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: ST7 [Title/Abstract] AND CAV1 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: ST7 [Title/Abstract] AND CAV1 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ST7(116593745)-CAV1(116199000), # samples:2
Anticipated loss of major functional domain due to fusion event.	ST7-CAV1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ST7-CAV1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ST7-CAV1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ST7-CAV1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ST7-CAV1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ST7-CAV1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. ST7-CAV1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ST7-CAV1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CAV1	GO:0009617	response to bacterium	24625804
Tgene	CAV1	GO:0010875	positive regulation of cholesterol efflux	24576892
Tgene	CAV1	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	25893292
Tgene	CAV1	GO:0031295	T cell costimulation	17287217
Tgene	CAV1	GO:0031623	receptor internalization	25893292
Tgene	CAV1	GO:0032091	negative regulation of protein binding	16890161
Tgene	CAV1	GO:0032570	response to progesterone	12388746
Tgene	CAV1	GO:0033137	negative regulation of peptidyl-serine phosphorylation	18081315
Tgene	CAV1	GO:0033138	positive regulation of peptidyl-serine phosphorylation	18081315
Tgene	CAV1	GO:0043627	response to estrogen	12388746
Tgene	CAV1	GO:0051480	regulation of cytosolic calcium ion concentration	19052258
Tgene	CAV1	GO:0072584	caveolin-mediated endocytosis	19931615
Tgene	CAV1	GO:1900027	regulation of ruffle assembly	24625804
Tgene	CAV1	GO:2000535	regulation of entry of bacterium into host cell	24625804

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:116593745/chr7:116199000)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across ST7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CAV1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000393446	ST7	chr7	116593745	+	ENST00000341049	CAV1	chr7	116198999	+	2685	454	391	104	95
ENST00000393446	ST7	chr7	116593745	+	ENST00000393470	CAV1	chr7	116198999	+	828	454	391	104	95
ENST00000393446	ST7	chr7	116593745	+	ENST00000405348	CAV1	chr7	116198999	+	2688	454	391	104	95
ENST00000393446	ST7	chr7	116593745	+	ENST00000393467	CAV1	chr7	116198999	+	2685	454	391	104	95
ENST00000265437	ST7	chr7	116593745	+	ENST00000341049	CAV1	chr7	116198999	+	2596	365	302	15	95
ENST00000265437	ST7	chr7	116593745	+	ENST00000393470	CAV1	chr7	116198999	+	739	365	302	15	95
ENST00000265437	ST7	chr7	116593745	+	ENST00000405348	CAV1	chr7	116198999	+	2599	365	302	15	95
ENST00000265437	ST7	chr7	116593745	+	ENST00000393467	CAV1	chr7	116198999	+	2596	365	302	15	95
ENST00000393451	ST7	chr7	116593745	+	ENST00000341049	CAV1	chr7	116198999	+	2581	350	287	0	96
ENST00000393451	ST7	chr7	116593745	+	ENST00000393470	CAV1	chr7	116198999	+	724	350	287	0	96
ENST00000393451	ST7	chr7	116593745	+	ENST00000405348	CAV1	chr7	116198999	+	2584	350	287	0	96
ENST00000393451	ST7	chr7	116593745	+	ENST00000393467	CAV1	chr7	116198999	+	2581	350	287	0	96
ENST00000393449	ST7	chr7	116593745	+	ENST00000341049	CAV1	chr7	116198999	+	2544	313	2069	1788	93
ENST00000393449	ST7	chr7	116593745	+	ENST00000393470	CAV1	chr7	116198999	+	687	313	250	2	83
ENST00000393449	ST7	chr7	116593745	+	ENST00000405348	CAV1	chr7	116198999	+	2547	313	2069	1788	93
ENST00000393449	ST7	chr7	116593745	+	ENST00000393467	CAV1	chr7	116198999	+	2544	313	2069	1788	93
ENST00000323984	ST7	chr7	116593745	+	ENST00000341049	CAV1	chr7	116198999	+	2544	313	2069	1788	93
ENST00000323984	ST7	chr7	116593745	+	ENST00000393470	CAV1	chr7	116198999	+	687	313	250	2	83
ENST00000323984	ST7	chr7	116593745	+	ENST00000405348	CAV1	chr7	116198999	+	2547	313	2069	1788	93
ENST00000323984	ST7	chr7	116593745	+	ENST00000393467	CAV1	chr7	116198999	+	2544	313	2069	1788	93
ENST00000393446	ST7	chr7	116593745	+	ENST00000341049	CAV1	chr7	116199000	+	2685	454	391	104	95
ENST00000393446	ST7	chr7	116593745	+	ENST00000393470	CAV1	chr7	116199000	+	828	454	391	104	95
ENST00000393446	ST7	chr7	116593745	+	ENST00000405348	CAV1	chr7	116199000	+	2688	454	391	104	95
ENST00000393446	ST7	chr7	116593745	+	ENST00000393467	CAV1	chr7	116199000	+	2685	454	391	104	95
ENST00000265437	ST7	chr7	116593745	+	ENST00000341049	CAV1	chr7	116199000	+	2596	365	302	15	95
ENST00000265437	ST7	chr7	116593745	+	ENST00000393470	CAV1	chr7	116199000	+	739	365	302	15	95
ENST00000265437	ST7	chr7	116593745	+	ENST00000405348	CAV1	chr7	116199000	+	2599	365	302	15	95
ENST00000265437	ST7	chr7	116593745	+	ENST00000393467	CAV1	chr7	116199000	+	2596	365	302	15	95
ENST00000393451	ST7	chr7	116593745	+	ENST00000341049	CAV1	chr7	116199000	+	2581	350	287	0	96
ENST00000393451	ST7	chr7	116593745	+	ENST00000393470	CAV1	chr7	116199000	+	724	350	287	0	96
ENST00000393451	ST7	chr7	116593745	+	ENST00000405348	CAV1	chr7	116199000	+	2584	350	287	0	96
ENST00000393451	ST7	chr7	116593745	+	ENST00000393467	CAV1	chr7	116199000	+	2581	350	287	0	96
ENST00000393449	ST7	chr7	116593745	+	ENST00000341049	CAV1	chr7	116199000	+	2544	313	2069	1788	93
ENST00000393449	ST7	chr7	116593745	+	ENST00000393470	CAV1	chr7	116199000	+	687	313	250	2	83
ENST00000393449	ST7	chr7	116593745	+	ENST00000405348	CAV1	chr7	116199000	+	2547	313	2069	1788	93
ENST00000393449	ST7	chr7	116593745	+	ENST00000393467	CAV1	chr7	116199000	+	2544	313	2069	1788	93
ENST00000323984	ST7	chr7	116593745	+	ENST00000341049	CAV1	chr7	116199000	+	2544	313	2069	1788	93
ENST00000323984	ST7	chr7	116593745	+	ENST00000393470	CAV1	chr7	116199000	+	687	313	250	2	83
ENST00000323984	ST7	chr7	116593745	+	ENST00000405348	CAV1	chr7	116199000	+	2547	313	2069	1788	93
ENST00000323984	ST7	chr7	116593745	+	ENST00000393467	CAV1	chr7	116199000	+	2544	313	2069	1788	93

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000393446	ENST00000341049	ST7	chr7	116593745	+	CAV1	chr7	116198999	+	0.5168897	0.48311034
ENST00000393446	ENST00000393470	ST7	chr7	116593745	+	CAV1	chr7	116198999	+	0.31987745	0.6801225
ENST00000393446	ENST00000405348	ST7	chr7	116593745	+	CAV1	chr7	116198999	+	0.5102221	0.48977792
ENST00000393446	ENST00000393467	ST7	chr7	116593745	+	CAV1	chr7	116198999	+	0.5168897	0.48311034
ENST00000265437	ENST00000341049	ST7	chr7	116593745	+	CAV1	chr7	116198999	+	0.5607969	0.4392031
ENST00000265437	ENST00000393470	ST7	chr7	116593745	+	CAV1	chr7	116198999	+	0.19880593	0.8011941
ENST00000265437	ENST00000405348	ST7	chr7	116593745	+	CAV1	chr7	116198999	+	0.56254756	0.43745247
ENST00000265437	ENST00000393467	ST7	chr7	116593745	+	CAV1	chr7	116198999	+	0.5607969	0.4392031
ENST00000393451	ENST00000341049	ST7	chr7	116593745	+	CAV1	chr7	116198999	+	0.48941132	0.5105887
ENST00000393451	ENST00000393470	ST7	chr7	116593745	+	CAV1	chr7	116198999	+	0.11590931	0.8840907
ENST00000393451	ENST00000405348	ST7	chr7	116593745	+	CAV1	chr7	116198999	+	0.4884464	0.5115536
ENST00000393451	ENST00000393467	ST7	chr7	116593745	+	CAV1	chr7	116198999	+	0.48941132	0.5105887
ENST00000393449	ENST00000341049	ST7	chr7	116593745	+	CAV1	chr7	116198999	+	0.29003033	0.7099697
ENST00000393449	ENST00000393470	ST7	chr7	116593745	+	CAV1	chr7	116198999	+	0.13552068	0.8644793
ENST00000393449	ENST00000405348	ST7	chr7	116593745	+	CAV1	chr7	116198999	+	0.29368955	0.70631045
ENST00000393449	ENST00000393467	ST7	chr7	116593745	+	CAV1	chr7	116198999	+	0.29003033	0.7099697
ENST00000323984	ENST00000341049	ST7	chr7	116593745	+	CAV1	chr7	116198999	+	0.29003033	0.7099697
ENST00000323984	ENST00000393470	ST7	chr7	116593745	+	CAV1	chr7	116198999	+	0.13552068	0.8644793
ENST00000323984	ENST00000405348	ST7	chr7	116593745	+	CAV1	chr7	116198999	+	0.29368955	0.70631045
ENST00000323984	ENST00000393467	ST7	chr7	116593745	+	CAV1	chr7	116198999	+	0.29003033	0.7099697
ENST00000393446	ENST00000341049	ST7	chr7	116593745	+	CAV1	chr7	116199000	+	0.5168897	0.48311034
ENST00000393446	ENST00000393470	ST7	chr7	116593745	+	CAV1	chr7	116199000	+	0.31987745	0.6801225
ENST00000393446	ENST00000405348	ST7	chr7	116593745	+	CAV1	chr7	116199000	+	0.5102221	0.48977792
ENST00000393446	ENST00000393467	ST7	chr7	116593745	+	CAV1	chr7	116199000	+	0.5168897	0.48311034
ENST00000265437	ENST00000341049	ST7	chr7	116593745	+	CAV1	chr7	116199000	+	0.5607969	0.4392031
ENST00000265437	ENST00000393470	ST7	chr7	116593745	+	CAV1	chr7	116199000	+	0.19880593	0.8011941
ENST00000265437	ENST00000405348	ST7	chr7	116593745	+	CAV1	chr7	116199000	+	0.56254756	0.43745247
ENST00000265437	ENST00000393467	ST7	chr7	116593745	+	CAV1	chr7	116199000	+	0.5607969	0.4392031
ENST00000393451	ENST00000341049	ST7	chr7	116593745	+	CAV1	chr7	116199000	+	0.48941132	0.5105887
ENST00000393451	ENST00000393470	ST7	chr7	116593745	+	CAV1	chr7	116199000	+	0.11590931	0.8840907
ENST00000393451	ENST00000405348	ST7	chr7	116593745	+	CAV1	chr7	116199000	+	0.4884464	0.5115536
ENST00000393451	ENST00000393467	ST7	chr7	116593745	+	CAV1	chr7	116199000	+	0.48941132	0.5105887
ENST00000393449	ENST00000341049	ST7	chr7	116593745	+	CAV1	chr7	116199000	+	0.29003033	0.7099697
ENST00000393449	ENST00000393470	ST7	chr7	116593745	+	CAV1	chr7	116199000	+	0.13552068	0.8644793
ENST00000393449	ENST00000405348	ST7	chr7	116593745	+	CAV1	chr7	116199000	+	0.29368955	0.70631045
ENST00000393449	ENST00000393467	ST7	chr7	116593745	+	CAV1	chr7	116199000	+	0.29003033	0.7099697
ENST00000323984	ENST00000341049	ST7	chr7	116593745	+	CAV1	chr7	116199000	+	0.29003033	0.7099697
ENST00000323984	ENST00000393470	ST7	chr7	116593745	+	CAV1	chr7	116199000	+	0.13552068	0.8644793
ENST00000323984	ENST00000405348	ST7	chr7	116593745	+	CAV1	chr7	116199000	+	0.29368955	0.70631045
ENST00000323984	ENST00000393467	ST7	chr7	116593745	+	CAV1	chr7	116199000	+	0.29003033	0.7099697

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

Top

Fusion Protein Breakpoint Sequences for ST7-CAV1

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Length(fusion protein)

BP in fusion protein

Peptide

Top

Potential FusionNeoAntigen Information of ST7-CAV1 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene

Hchr

Hbp

Tgene

Tchr

Tbp

HLA I

FusionNeoAntigen peptide

Binding score

Immunogenic score

Neoantigen start (at BP 13)

Neoantigen end (at BP 13)

Top

Potential FusionNeoAntigen Information of ST7-CAV1 in HLA II

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene

Hchr

Hbp

Tgene

Tchr

Tbp

HLA II

FusionNeoAntigen peptide

Neoantigen start (at BP 13)

Neoantigen end (at BP 13)

Top

Fusion breakpoint peptide structures of ST7-CAV1

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

Top

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ST7-CAV1

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele

PDB ID

File name

BPseq

Docking score

Glide score

Top

Vaccine Design for the FusionNeoAntigens of ST7-CAV1

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene

Hchr

Hbp

Tchr

Tbp

Start in +/-13AA

End in +/-13AA

FusionNeoAntigen peptide sequence

FusionNeoAntigen RNA sequence

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene

Hchr

Hbp

Tchr

Tbp

Start in +/-13AA

End in +/-13AA

FusionNeoAntigen peptide

FusionNEoAntigen RNA sequence

Top

Information of the samples that have these potential fusion neoantigens of ST7-CAV1

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type

Fusion gene

Hchr

Hbp

Henst

Tchr

Tbp

Tenst

Sample

Top

Potential target of CAR-T therapy development for ST7-CAV1

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ST7

chr7:116593745

chr7:116198999

ENST00000265437

15_35

586.0

Transmembrane

Helical

Hgene

ST7

chr7:116593745

chr7:116198999

ENST00000393451

15_35

555.0

Transmembrane

Helical

Hgene

ST7

chr7:116593745

chr7:116199000

ENST00000265437

15_35

586.0

Transmembrane

Helical

Hgene

ST7

chr7:116593745

chr7:116199000

ENST00000393451

15_35

555.0

Transmembrane

Helical

Tgene

CAV1

chr7:116593745

chr7:116198999

ENST00000341049

105_125

179.0

Intramembrane

Helical

Tgene

CAV1

chr7:116593745

chr7:116198999

ENST00000393467

105_125

148.0

Intramembrane

Helical

Tgene

CAV1

chr7:116593745

chr7:116198999

ENST00000393468

105_125

148.0

Intramembrane

Helical

Tgene

CAV1

chr7:116593745

chr7:116198999

ENST00000405348

105_125

148.0

Intramembrane

Helical

Tgene

CAV1

chr7:116593745

chr7:116199000

ENST00000341049

105_125

179.0

Intramembrane

Helical

Tgene

CAV1

chr7:116593745

chr7:116199000

ENST00000393467

105_125

148.0

Intramembrane

Helical

Tgene

CAV1

chr7:116593745

chr7:116199000

ENST00000393468

105_125

148.0

Intramembrane

Helical

Tgene

CAV1

chr7:116593745

chr7:116199000

ENST00000405348

105_125

148.0

Intramembrane

Helical

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

Top

Related Drugs to ST7-CAV1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ST7-CAV1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)