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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:ST7-MET

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ST7-MET
FusionPDB ID: 87032
FusionGDB2.0 ID: 87032
HgeneTgene
Gene symbol

ST7

MET

Gene ID

93655

8731

Gene nameST7 overlapping transcript 3RNA guanine-7 methyltransferase
SynonymsNCRNA00026|ST7|ST7OT3CMT1|CMT1c|MET|Met|RG7MT1|cm1p|hCMT1|hMet
Cytomap

7q31.2

18p11.21

Type of genencRNAprotein-coding
DescriptionST7 overlapping transcript 3 (non-coding RNA)ST7 overlapping transcript 3 (non-protein coding)suppression of tumorigenicity 7mRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferase
Modification date2020031320200329
UniProtAcc.

Q9H1A3

Main function of 5'-partner protein:
Ensembl transtripts involved in fusion geneENST idsENST00000487459, ENST00000265437, 
ENST00000323984, ENST00000393443, 
ENST00000393444, ENST00000393446, 
ENST00000393447, ENST00000393449, 
ENST00000393451, ENST00000422922, 
ENST00000432298, ENST00000465133, 
ENST00000318493, ENST00000397752, 
ENST00000436117, ENST00000495962, 
ENST00000539704, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 11 X 9=168314 X 18 X 10=2520
# samples 2327
** MAII scorelog2(23/1683*10)=-2.87132941038557
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/2520*10)=-3.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: ST7 [Title/Abstract] AND MET [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: ST7 [Title/Abstract] AND MET [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ST7(116593745)-MET(116339125), # samples:3
Anticipated loss of major functional domain due to fusion event.ST7-MET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ST7-MET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ST7-MET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ST7-MET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ST7-MET seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ST7-MET seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
ST7-MET seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
ST7-MET seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ST7-MET seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMET

GO:0006370

7-methylguanosine mRNA capping

27422871



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:116593745/chr7:116339125)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across ST7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393446ST7chr7116830990-ENST00000397752METchr7116371722+6723148830344601385
ENST00000393446ST7chr7116830990-ENST00000318493METchr7116371722+4733148830345141403
ENST00000393446ST7chr7116830990-ENST00000436117METchr7116371722+258314883032582759
ENST00000265437ST7chr7116830990-ENST00000397752METchr7116371722+6703146821444401408
ENST00000265437ST7chr7116830990-ENST00000318493METchr7116371722+4713146821444941426
ENST00000265437ST7chr7116830990-ENST00000436117METchr7116371722+256314682142562783
ENST00000393451ST7chr7116830990-ENST00000397752METchr7116371722+6619138419943561385
ENST00000393451ST7chr7116830990-ENST00000318493METchr7116371722+4629138419944101403
ENST00000393451ST7chr7116830990-ENST00000436117METchr7116371722+247913841992478760
ENST00000393449ST7chr7116830990-ENST00000397752METchr7116371722+6651141616243881408
ENST00000393449ST7chr7116830990-ENST00000318493METchr7116371722+4661141616244421426
ENST00000393449ST7chr7116830990-ENST00000436117METchr7116371722+251114161622510782
ENST00000323984ST7chr7116830990-ENST00000397752METchr7116371722+6651141616243881408
ENST00000323984ST7chr7116830990-ENST00000318493METchr7116371722+4661141616244421426
ENST00000323984ST7chr7116830990-ENST00000436117METchr7116371722+251114161622510782
ENST00000432298ST7chr7116830990-ENST00000397752METchr7116371722+646512306342021379
ENST00000432298ST7chr7116830990-ENST00000318493METchr7116371722+447512306342561397
ENST00000432298ST7chr7116830990-ENST00000436117METchr7116371722+23251230632324753
ENST00000422922ST7chr7116830990-ENST00000397752METchr7116371722+639611616341331356
ENST00000422922ST7chr7116830990-ENST00000318493METchr7116371722+440611616341871374
ENST00000422922ST7chr7116830990-ENST00000436117METchr7116371722+22561161632255730
ENST00000393443ST7chr7116830990-ENST00000397752METchr7116371722+6884164961446211335
ENST00000393443ST7chr7116830990-ENST00000318493METchr7116371722+4894164961446751353
ENST00000393443ST7chr7116830990-ENST00000436117METchr7116371722+274416496142743710
ENST00000393447ST7chr7116830990-ENST00000397752METchr7116371722+6691145621444281404
ENST00000393447ST7chr7116830990-ENST00000318493METchr7116371722+4701145621444821422
ENST00000393447ST7chr7116830990-ENST00000436117METchr7116371722+255114562142550779
ENST00000393444ST7chr7116830990-ENST00000397752METchr7116371722+6622138721443591381
ENST00000393444ST7chr7116830990-ENST00000318493METchr7116371722+4632138721444131399
ENST00000393444ST7chr7116830990-ENST00000436117METchr7116371722+248213872142481756

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393446ENST00000397752ST7chr7116830990-METchr7116371722+0.0003102340.9996898
ENST00000393446ENST00000318493ST7chr7116830990-METchr7116371722+0.000389460.9996106
ENST00000393446ENST00000436117ST7chr7116830990-METchr7116371722+0.0022945950.9977054
ENST00000265437ENST00000397752ST7chr7116830990-METchr7116371722+0.0002770750.9997229
ENST00000265437ENST00000318493ST7chr7116830990-METchr7116371722+0.0003462970.9996537
ENST00000265437ENST00000436117ST7chr7116830990-METchr7116371722+0.0022708330.99772924
ENST00000393451ENST00000397752ST7chr7116830990-METchr7116371722+0.0002795580.9997204
ENST00000393451ENST00000318493ST7chr7116830990-METchr7116371722+0.0003634840.99963653
ENST00000393451ENST00000436117ST7chr7116830990-METchr7116371722+0.0026668950.99733317
ENST00000393449ENST00000397752ST7chr7116830990-METchr7116371722+0.0002600470.99973994
ENST00000393449ENST00000318493ST7chr7116830990-METchr7116371722+0.0003314690.9996686
ENST00000393449ENST00000436117ST7chr7116830990-METchr7116371722+0.0024224750.9975775
ENST00000323984ENST00000397752ST7chr7116830990-METchr7116371722+0.0002600470.99973994
ENST00000323984ENST00000318493ST7chr7116830990-METchr7116371722+0.0003314690.9996686
ENST00000323984ENST00000436117ST7chr7116830990-METchr7116371722+0.0024224750.9975775
ENST00000432298ENST00000397752ST7chr7116830990-METchr7116371722+0.0002238330.9997762
ENST00000432298ENST00000318493ST7chr7116830990-METchr7116371722+0.0002608260.9997391
ENST00000432298ENST00000436117ST7chr7116830990-METchr7116371722+0.0021383880.99786156
ENST00000422922ENST00000397752ST7chr7116830990-METchr7116371722+0.0002256570.9997744
ENST00000422922ENST00000318493ST7chr7116830990-METchr7116371722+0.0002803230.9997197
ENST00000422922ENST00000436117ST7chr7116830990-METchr7116371722+0.0024967650.9975032
ENST00000393443ENST00000397752ST7chr7116830990-METchr7116371722+0.0004479060.9995521
ENST00000393443ENST00000318493ST7chr7116830990-METchr7116371722+0.0005115450.9994885
ENST00000393443ENST00000436117ST7chr7116830990-METchr7116371722+0.004686280.99531376
ENST00000393447ENST00000397752ST7chr7116830990-METchr7116371722+0.0003213820.9996786
ENST00000393447ENST00000318493ST7chr7116830990-METchr7116371722+0.0003806910.99961925
ENST00000393447ENST00000436117ST7chr7116830990-METchr7116371722+0.0023347920.9976653
ENST00000393444ENST00000397752ST7chr7116830990-METchr7116371722+0.0003263070.9996737
ENST00000393444ENST00000318493ST7chr7116830990-METchr7116371722+0.0004038660.9995962
ENST00000393444ENST00000436117ST7chr7116830990-METchr7116371722+0.0031461470.9968539

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for ST7-MET

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
ST7chr7116830990METchr71163717221161366IHRAVEFNPHVPKTLLRNSSGCEARR
ST7chr7116830990METchr71163717221230389IHRAVEFNPHVPKTLLRNSSGCEARR
ST7chr7116830990METchr71163717221384395IHRAVEFNPHVPKTLLRNSSGCEARR
ST7chr7116830990METchr71163717221387391IHRAVEFNPHVPKTLLRNSSGCEARR
ST7chr7116830990METchr71163717221416418IHRAVEFNPHVPKTLLRNSSGCEARR
ST7chr7116830990METchr71163717221456414IHRAVEFNPHVPKTLLRNSSGCEARR
ST7chr7116830990METchr71163717221468418IHRAVEFNPHVPKTLLRNSSGCEARR
ST7chr7116830990METchr71163717221488395IHRAVEFNPHVPKTLLRNSSGCEARR
ST7chr7116830990METchr71163717221649345IHRAVEFNPHVPKTLLRNSSGCEARR

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Potential FusionNeoAntigen Information of ST7-MET in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
ST7-MET_116830990_116371722.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
ST7-METchr7116830990chr71163717221468HLA-B35:03NPHVPKTL0.95480.866715
ST7-METchr7116830990chr71163717221468HLA-B35:02NPHVPKTL0.84850.8856715
ST7-METchr7116830990chr71163717221468HLA-B35:04NPHVPKTL0.84850.8856715
ST7-METchr7116830990chr71163717221468HLA-B14:02NPHVPKTLL0.89010.5714716
ST7-METchr7116830990chr71163717221468HLA-B14:01NPHVPKTLL0.89010.5714716
ST7-METchr7116830990chr71163717221468HLA-B35:03NPHVPKTLL0.86590.8371716
ST7-METchr7116830990chr71163717221468HLA-B35:02NPHVPKTLL0.65980.8424716
ST7-METchr7116830990chr71163717221468HLA-B35:04NPHVPKTLL0.65980.8424716
ST7-METchr7116830990chr71163717221468HLA-B35:05NPHVPKTLL0.610.512716
ST7-METchr7116830990chr71163717221468HLA-B35:03FNPHVPKTLL0.60360.9182616
ST7-METchr7116830990chr71163717221468HLA-B35:04FNPHVPKTLL0.51450.9092616
ST7-METchr7116830990chr71163717221468HLA-B35:02FNPHVPKTLL0.51450.9092616
ST7-METchr7116830990chr71163717221468HLA-B47:01VEFNPHVPKTL0.99790.5185415
ST7-METchr7116830990chr71163717221468HLA-B44:03VEFNPHVPKTL0.98730.9484415
ST7-METchr7116830990chr71163717221468HLA-B39:13VEFNPHVPKTL0.96390.9061415
ST7-METchr7116830990chr71163717221468HLA-B14:03NPHVPKTL0.99240.6948715
ST7-METchr7116830990chr71163717221468HLA-B07:12NPHVPKTL0.97120.5981715
ST7-METchr7116830990chr71163717221468HLA-B35:12NPHVPKTL0.84850.8856715
ST7-METchr7116830990chr71163717221468HLA-B39:10NPHVPKTL0.73330.861715
ST7-METchr7116830990chr71163717221468HLA-B07:12NPHVPKTLL0.95520.5993716
ST7-METchr7116830990chr71163717221468HLA-C06:03FNPHVPKTL0.87890.9926615
ST7-METchr7116830990chr71163717221468HLA-B14:03NPHVPKTLL0.77670.6584716
ST7-METchr7116830990chr71163717221468HLA-C01:17FNPHVPKTL0.69090.9043615
ST7-METchr7116830990chr71163717221468HLA-B35:12NPHVPKTLL0.65980.8424716
ST7-METchr7116830990chr71163717221468HLA-B39:10NPHVPKTLL0.64590.8314716
ST7-METchr7116830990chr71163717221468HLA-C07:13FNPHVPKTL0.64310.8428615
ST7-METchr7116830990chr71163717221468HLA-C07:29FNPHVPKTL0.56460.9069615
ST7-METchr7116830990chr71163717221468HLA-C01:30FNPHVPKTL0.51130.9053615
ST7-METchr7116830990chr71163717221468HLA-B40:06VEFNPHVPKT0.98470.5403414
ST7-METchr7116830990chr71163717221468HLA-B42:02FNPHVPKTLL0.87260.5256616
ST7-METchr7116830990chr71163717221468HLA-B42:01FNPHVPKTLL0.83360.5271616
ST7-METchr7116830990chr71163717221468HLA-B39:10FNPHVPKTLL0.80220.8792616
ST7-METchr7116830990chr71163717221468HLA-B07:12FNPHVPKTLL0.71240.702616
ST7-METchr7116830990chr71163717221468HLA-B35:12FNPHVPKTLL0.51450.9092616
ST7-METchr7116830990chr71163717221468HLA-B08:12NPHVPKTL0.94610.5511715
ST7-METchr7116830990chr71163717221468HLA-B35:09NPHVPKTL0.84850.8856715
ST7-METchr7116830990chr71163717221468HLA-B67:01NPHVPKTL0.81290.5746715
ST7-METchr7116830990chr71163717221468HLA-B18:07NPHVPKTL0.44760.8381715
ST7-METchr7116830990chr71163717221468HLA-C03:67FNPHVPKTL0.98250.9784615
ST7-METchr7116830990chr71163717221468HLA-B35:13NPHVPKTLL0.85470.8403716
ST7-METchr7116830990chr71163717221468HLA-C07:04FNPHVPKTL0.77310.8151615
ST7-METchr7116830990chr71163717221468HLA-C06:02FNPHVPKTL0.75180.9906615
ST7-METchr7116830990chr71163717221468HLA-C06:17FNPHVPKTL0.75180.9906615
ST7-METchr7116830990chr71163717221468HLA-C06:06FNPHVPKTL0.68890.9818615
ST7-METchr7116830990chr71163717221468HLA-C01:02FNPHVPKTL0.68050.9041615
ST7-METchr7116830990chr71163717221468HLA-B35:09NPHVPKTLL0.65980.8424716
ST7-METchr7116830990chr71163717221468HLA-B67:01NPHVPKTLL0.65780.5359716
ST7-METchr7116830990chr71163717221468HLA-B35:17NPHVPKTLL0.61630.7001716
ST7-METchr7116830990chr71163717221468HLA-B35:30NPHVPKTLL0.61630.7001716
ST7-METchr7116830990chr71163717221468HLA-B08:12NPHVPKTLL0.51750.5702716
ST7-METchr7116830990chr71163717221468HLA-C01:03FNPHVPKTL0.49490.8333615
ST7-METchr7116830990chr71163717221468HLA-B35:24NPHVPKTLL0.47940.8338716
ST7-METchr7116830990chr71163717221468HLA-C06:08FNPHVPKTL0.27750.9887615
ST7-METchr7116830990chr71163717221468HLA-B18:07NPHVPKTLL0.01930.7952716
ST7-METchr7116830990chr71163717221468HLA-B67:01FNPHVPKTLL0.75670.5901616
ST7-METchr7116830990chr71163717221468HLA-B35:09FNPHVPKTLL0.51450.9092616
ST7-METchr7116830990chr71163717221468HLA-B40:04VEFNPHVPKTL0.99960.6727415
ST7-METchr7116830990chr71163717221468HLA-B44:07VEFNPHVPKTL0.98730.9484415
ST7-METchr7116830990chr71163717221468HLA-B44:13VEFNPHVPKTL0.98730.9484415
ST7-METchr7116830990chr71163717221468HLA-B44:26VEFNPHVPKTL0.98730.9484415
ST7-METchr7116830990chr71163717221468HLA-B39:02VEFNPHVPKTL0.97340.911415
ST7-METchr7116830990chr71163717221468HLA-B41:03VEFNPHVPKTL0.96550.7047415

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Potential FusionNeoAntigen Information of ST7-MET in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
ST7-MET_116830990_116371722.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
ST7-METchr7116830990chr71163717221468DRB1-0103AVEFNPHVPKTLLRN318
ST7-METchr7116830990chr71163717221468DRB1-0303IHRAVEFNPHVPKTL015
ST7-METchr7116830990chr71163717221468DRB1-0303HRAVEFNPHVPKTLL116

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Fusion breakpoint peptide structures of ST7-MET

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
2483FNPHVPKTLLRNSSST7METchr7116830990chr71163717221468

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ST7-MET

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN2483FNPHVPKTLLRNSS-5.50071-6.53601
HLA-B14:023BVN2483FNPHVPKTLLRNSS-5.44997-5.56337
HLA-B52:013W392483FNPHVPKTLLRNSS-6.87928-6.99268
HLA-B52:013W392483FNPHVPKTLLRNSS-3.95744-4.99274
HLA-A24:025HGA2483FNPHVPKTLLRNSS-7.30598-7.41938
HLA-A24:025HGA2483FNPHVPKTLLRNSS-5.09366-6.12896
HLA-B44:053DX82483FNPHVPKTLLRNSS-5.64505-5.75845
HLA-B44:053DX82483FNPHVPKTLLRNSS-4.1878-5.2231
HLA-A02:016TDR2483FNPHVPKTLLRNSS-0.0912853-1.12659

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Vaccine Design for the FusionNeoAntigens of ST7-MET

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
ST7-METchr7116830990chr7116371722414VEFNPHVPKTGTGGAATTCAATCCTCATGTGCCAAAAACA
ST7-METchr7116830990chr7116371722415VEFNPHVPKTLGTGGAATTCAATCCTCATGTGCCAAAAACACTT
ST7-METchr7116830990chr7116371722615FNPHVPKTLTTCAATCCTCATGTGCCAAAAACACTT
ST7-METchr7116830990chr7116371722616FNPHVPKTLLTTCAATCCTCATGTGCCAAAAACACTTCTG
ST7-METchr7116830990chr7116371722715NPHVPKTLAATCCTCATGTGCCAAAAACACTT
ST7-METchr7116830990chr7116371722716NPHVPKTLLAATCCTCATGTGCCAAAAACACTTCTG

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
ST7-METchr7116830990chr7116371722015IHRAVEFNPHVPKTLATTCATAGAGCTGTGGAATTCAATCCTCATGTGCCAAAAACACTT
ST7-METchr7116830990chr7116371722116HRAVEFNPHVPKTLLCATAGAGCTGTGGAATTCAATCCTCATGTGCCAAAAACACTTCTG
ST7-METchr7116830990chr7116371722318AVEFNPHVPKTLLRNGCTGTGGAATTCAATCCTCATGTGCCAAAAACACTTCTGAGAAAT

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Information of the samples that have these potential fusion neoantigens of ST7-MET

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
LIHCST7-METchr7116830990ENST00000265437chr7116371722ENST00000318493TCGA-DD-AAE2-01A

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Potential target of CAR-T therapy development for ST7-MET

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneST7chr7:116830990chr7:116371722ENST00000265437-121615_35418586.0TransmembraneHelical
HgeneST7chr7:116830990chr7:116371722ENST00000265437-121662_82418586.0TransmembraneHelical
HgeneST7chr7:116830990chr7:116371722ENST00000393443-121615_35345500.0TransmembraneHelical
HgeneST7chr7:116830990chr7:116371722ENST00000393443-121662_82345500.0TransmembraneHelical
HgeneST7chr7:116830990chr7:116371722ENST00000393451-111515_35395555.0TransmembraneHelical
HgeneST7chr7:116830990chr7:116371722ENST00000393451-111562_82395555.0TransmembraneHelical
TgeneMETchr7:116830990chr7:116371722ENST00000318493121933_95501409.0TransmembraneHelical
TgeneMETchr7:116830990chr7:116371722ENST00000397752121933_95501391.0TransmembraneHelical
TgeneMETchr7:116830990chr7:116371722ENST0000043611709933_9550765.0TransmembraneHelical

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to ST7-MET

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ST7-MET

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource