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Fusion Protein:TANK-SEC31A

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TANK-SEC31A
	FusionPDB ID: 88995
	FusionGDB2.0 ID: 88995
		Hgene	Tgene
	Gene symbol	TANK	SEC31A
	Gene ID	10010	22872
	Gene name	TRAF family member associated NFKB activator	SEC31 homolog A, COPII coat complex component
	Synonyms	I-TRAF\|ITRAF\|TRAF2	ABP125\|ABP130\|HSPC275\|HSPC334\|NEDSOSB\|SEC31L1
	Cytomap	2q24.2	4q21.22
	Type of gene	protein-coding	protein-coding
	Description	TRAF family member-associated NF-kappa-B activatorTRAF-interacting protein	protein transport protein Sec31ASEC31 homolog A, COPII coating complex componentSEC31-like protein 1SEC31-related protein Aweb1-like proteinyeast Sec31p homolog
	Modification date	20200313	20200313
	UniProtAcc	TBKBP1 Main function of 5'-partner protein: 615	O94979 Main function of 5'-partner protein: FUNCTION: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250\|UniProtKB:Q9Z2Q1, ECO:0000269\|PubMed:10788476}.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000259075, ENST00000392749, ENST00000402568, ENST00000403609, ENST00000405852, ENST00000406287, ENST00000457476, ENST00000461338,	ENST00000436790, ENST00000508479, ENST00000264405, ENST00000311785, ENST00000326950, ENST00000348405, ENST00000355196, ENST00000395310, ENST00000432794, ENST00000443462, ENST00000448323, ENST00000500777, ENST00000505472, ENST00000505984, ENST00000508502, ENST00000509142, ENST00000513858,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 8 X 6=432	27 X 19 X 11=5643
	# samples	9	28
	** MAII score	log2(9/432*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(28/5643*10)=-4.33296361729939 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: TANK [Title/Abstract] AND SEC31A [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: TANK [Title/Abstract] AND SEC31A [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TANK(162061304)-SEC31A(83745827), # samples:1
Anticipated loss of major functional domain due to fusion event.	TANK-SEC31A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TANK-SEC31A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TANK-SEC31A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TANK-SEC31A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SEC31A	GO:0051592	response to calcium ion	17196169
Tgene	SEC31A	GO:0090110	cargo loading into COPII-coated vesicle	17499046\|18843296

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:162061304/chr4:83745827)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across TANK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SEC31A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000259075	TANK	chr2	162061304	+	ENST00000348405	SEC31A	chr4	83745827	-	1317	532	97	903	268
ENST00000259075	TANK	chr2	162061304	+	ENST00000513858	SEC31A	chr4	83745827	-	1317	532	97	903	268
ENST00000259075	TANK	chr2	162061304	+	ENST00000395310	SEC31A	chr4	83745827	-	1317	532	97	903	268
ENST00000259075	TANK	chr2	162061304	+	ENST00000443462	SEC31A	chr4	83745827	-	1316	532	97	903	268
ENST00000259075	TANK	chr2	162061304	+	ENST00000509142	SEC31A	chr4	83745827	-	1316	532	97	903	268
ENST00000259075	TANK	chr2	162061304	+	ENST00000326950	SEC31A	chr4	83745827	-	1316	532	97	903	268
ENST00000259075	TANK	chr2	162061304	+	ENST00000432794	SEC31A	chr4	83745827	-	1316	532	97	903	268
ENST00000259075	TANK	chr2	162061304	+	ENST00000311785	SEC31A	chr4	83745827	-	1316	532	97	903	268
ENST00000259075	TANK	chr2	162061304	+	ENST00000448323	SEC31A	chr4	83745827	-	1316	532	97	903	268
ENST00000259075	TANK	chr2	162061304	+	ENST00000505472	SEC31A	chr4	83745827	-	1306	532	97	903	268
ENST00000259075	TANK	chr2	162061304	+	ENST00000500777	SEC31A	chr4	83745827	-	1306	532	97	903	268
ENST00000259075	TANK	chr2	162061304	+	ENST00000508502	SEC31A	chr4	83745827	-	967	532	97	903	268
ENST00000259075	TANK	chr2	162061304	+	ENST00000355196	SEC31A	chr4	83745827	-	967	532	97	903	268
ENST00000259075	TANK	chr2	162061304	+	ENST00000264405	SEC31A	chr4	83745827	-	956	532	97	903	268
ENST00000259075	TANK	chr2	162061304	+	ENST00000505984	SEC31A	chr4	83745827	-	934	532	97	903	268
ENST00000457476	TANK	chr2	162061304	+	ENST00000348405	SEC31A	chr4	83745827	-	1337	552	50	412	120
ENST00000457476	TANK	chr2	162061304	+	ENST00000513858	SEC31A	chr4	83745827	-	1337	552	50	412	120
ENST00000457476	TANK	chr2	162061304	+	ENST00000395310	SEC31A	chr4	83745827	-	1337	552	50	412	120
ENST00000457476	TANK	chr2	162061304	+	ENST00000443462	SEC31A	chr4	83745827	-	1336	552	50	412	120
ENST00000457476	TANK	chr2	162061304	+	ENST00000509142	SEC31A	chr4	83745827	-	1336	552	50	412	120
ENST00000457476	TANK	chr2	162061304	+	ENST00000326950	SEC31A	chr4	83745827	-	1336	552	50	412	120
ENST00000457476	TANK	chr2	162061304	+	ENST00000432794	SEC31A	chr4	83745827	-	1336	552	50	412	120
ENST00000457476	TANK	chr2	162061304	+	ENST00000311785	SEC31A	chr4	83745827	-	1336	552	50	412	120
ENST00000457476	TANK	chr2	162061304	+	ENST00000448323	SEC31A	chr4	83745827	-	1336	552	50	412	120
ENST00000457476	TANK	chr2	162061304	+	ENST00000505472	SEC31A	chr4	83745827	-	1326	552	50	412	120
ENST00000457476	TANK	chr2	162061304	+	ENST00000500777	SEC31A	chr4	83745827	-	1326	552	50	412	120
ENST00000457476	TANK	chr2	162061304	+	ENST00000508502	SEC31A	chr4	83745827	-	987	552	50	412	120
ENST00000457476	TANK	chr2	162061304	+	ENST00000355196	SEC31A	chr4	83745827	-	987	552	50	412	120
ENST00000457476	TANK	chr2	162061304	+	ENST00000264405	SEC31A	chr4	83745827	-	976	552	50	412	120
ENST00000457476	TANK	chr2	162061304	+	ENST00000505984	SEC31A	chr4	83745827	-	954	552	50	412	120
ENST00000392749	TANK	chr2	162061304	+	ENST00000348405	SEC31A	chr4	83745827	-	1351	566	239	937	232
ENST00000392749	TANK	chr2	162061304	+	ENST00000513858	SEC31A	chr4	83745827	-	1351	566	239	937	232
ENST00000392749	TANK	chr2	162061304	+	ENST00000395310	SEC31A	chr4	83745827	-	1351	566	239	937	232
ENST00000392749	TANK	chr2	162061304	+	ENST00000443462	SEC31A	chr4	83745827	-	1350	566	239	937	232
ENST00000392749	TANK	chr2	162061304	+	ENST00000509142	SEC31A	chr4	83745827	-	1350	566	239	937	232
ENST00000392749	TANK	chr2	162061304	+	ENST00000326950	SEC31A	chr4	83745827	-	1350	566	239	937	232
ENST00000392749	TANK	chr2	162061304	+	ENST00000432794	SEC31A	chr4	83745827	-	1350	566	239	937	232
ENST00000392749	TANK	chr2	162061304	+	ENST00000311785	SEC31A	chr4	83745827	-	1350	566	239	937	232
ENST00000392749	TANK	chr2	162061304	+	ENST00000448323	SEC31A	chr4	83745827	-	1350	566	239	937	232
ENST00000392749	TANK	chr2	162061304	+	ENST00000505472	SEC31A	chr4	83745827	-	1340	566	239	937	232
ENST00000392749	TANK	chr2	162061304	+	ENST00000500777	SEC31A	chr4	83745827	-	1340	566	239	937	232
ENST00000392749	TANK	chr2	162061304	+	ENST00000508502	SEC31A	chr4	83745827	-	1001	566	239	937	232
ENST00000392749	TANK	chr2	162061304	+	ENST00000355196	SEC31A	chr4	83745827	-	1001	566	239	937	232
ENST00000392749	TANK	chr2	162061304	+	ENST00000264405	SEC31A	chr4	83745827	-	990	566	239	937	232
ENST00000392749	TANK	chr2	162061304	+	ENST00000505984	SEC31A	chr4	83745827	-	968	566	239	937	232
ENST00000402568	TANK	chr2	162061304	+	ENST00000348405	SEC31A	chr4	83745827	-	1430	645	36	1016	326
ENST00000402568	TANK	chr2	162061304	+	ENST00000513858	SEC31A	chr4	83745827	-	1430	645	36	1016	326
ENST00000402568	TANK	chr2	162061304	+	ENST00000395310	SEC31A	chr4	83745827	-	1430	645	36	1016	326
ENST00000402568	TANK	chr2	162061304	+	ENST00000443462	SEC31A	chr4	83745827	-	1429	645	36	1016	326
ENST00000402568	TANK	chr2	162061304	+	ENST00000509142	SEC31A	chr4	83745827	-	1429	645	36	1016	326
ENST00000402568	TANK	chr2	162061304	+	ENST00000326950	SEC31A	chr4	83745827	-	1429	645	36	1016	326
ENST00000402568	TANK	chr2	162061304	+	ENST00000432794	SEC31A	chr4	83745827	-	1429	645	36	1016	326
ENST00000402568	TANK	chr2	162061304	+	ENST00000311785	SEC31A	chr4	83745827	-	1429	645	36	1016	326
ENST00000402568	TANK	chr2	162061304	+	ENST00000448323	SEC31A	chr4	83745827	-	1429	645	36	1016	326
ENST00000402568	TANK	chr2	162061304	+	ENST00000505472	SEC31A	chr4	83745827	-	1419	645	36	1016	326
ENST00000402568	TANK	chr2	162061304	+	ENST00000500777	SEC31A	chr4	83745827	-	1419	645	36	1016	326
ENST00000402568	TANK	chr2	162061304	+	ENST00000508502	SEC31A	chr4	83745827	-	1080	645	36	1016	326
ENST00000402568	TANK	chr2	162061304	+	ENST00000355196	SEC31A	chr4	83745827	-	1080	645	36	1016	326
ENST00000402568	TANK	chr2	162061304	+	ENST00000264405	SEC31A	chr4	83745827	-	1069	645	36	1016	326
ENST00000402568	TANK	chr2	162061304	+	ENST00000505984	SEC31A	chr4	83745827	-	1047	645	36	1016	326
ENST00000406287	TANK	chr2	162061304	+	ENST00000348405	SEC31A	chr4	83745827	-	1427	642	36	1013	325
ENST00000406287	TANK	chr2	162061304	+	ENST00000513858	SEC31A	chr4	83745827	-	1427	642	36	1013	325
ENST00000406287	TANK	chr2	162061304	+	ENST00000395310	SEC31A	chr4	83745827	-	1427	642	36	1013	325
ENST00000406287	TANK	chr2	162061304	+	ENST00000443462	SEC31A	chr4	83745827	-	1426	642	36	1013	325
ENST00000406287	TANK	chr2	162061304	+	ENST00000509142	SEC31A	chr4	83745827	-	1426	642	36	1013	325
ENST00000406287	TANK	chr2	162061304	+	ENST00000326950	SEC31A	chr4	83745827	-	1426	642	36	1013	325
ENST00000406287	TANK	chr2	162061304	+	ENST00000432794	SEC31A	chr4	83745827	-	1426	642	36	1013	325
ENST00000406287	TANK	chr2	162061304	+	ENST00000311785	SEC31A	chr4	83745827	-	1426	642	36	1013	325
ENST00000406287	TANK	chr2	162061304	+	ENST00000448323	SEC31A	chr4	83745827	-	1426	642	36	1013	325
ENST00000406287	TANK	chr2	162061304	+	ENST00000505472	SEC31A	chr4	83745827	-	1416	642	36	1013	325
ENST00000406287	TANK	chr2	162061304	+	ENST00000500777	SEC31A	chr4	83745827	-	1416	642	36	1013	325
ENST00000406287	TANK	chr2	162061304	+	ENST00000508502	SEC31A	chr4	83745827	-	1077	642	36	1013	325
ENST00000406287	TANK	chr2	162061304	+	ENST00000355196	SEC31A	chr4	83745827	-	1077	642	36	1013	325
ENST00000406287	TANK	chr2	162061304	+	ENST00000264405	SEC31A	chr4	83745827	-	1066	642	36	1013	325
ENST00000406287	TANK	chr2	162061304	+	ENST00000505984	SEC31A	chr4	83745827	-	1044	642	36	1013	325
ENST00000405852	TANK	chr2	162061304	+	ENST00000348405	SEC31A	chr4	83745827	-	1209	424	97	795	232
ENST00000405852	TANK	chr2	162061304	+	ENST00000513858	SEC31A	chr4	83745827	-	1209	424	97	795	232
ENST00000405852	TANK	chr2	162061304	+	ENST00000395310	SEC31A	chr4	83745827	-	1209	424	97	795	232
ENST00000405852	TANK	chr2	162061304	+	ENST00000443462	SEC31A	chr4	83745827	-	1208	424	97	795	232
ENST00000405852	TANK	chr2	162061304	+	ENST00000509142	SEC31A	chr4	83745827	-	1208	424	97	795	232
ENST00000405852	TANK	chr2	162061304	+	ENST00000326950	SEC31A	chr4	83745827	-	1208	424	97	795	232
ENST00000405852	TANK	chr2	162061304	+	ENST00000432794	SEC31A	chr4	83745827	-	1208	424	97	795	232
ENST00000405852	TANK	chr2	162061304	+	ENST00000311785	SEC31A	chr4	83745827	-	1208	424	97	795	232
ENST00000405852	TANK	chr2	162061304	+	ENST00000448323	SEC31A	chr4	83745827	-	1208	424	97	795	232
ENST00000405852	TANK	chr2	162061304	+	ENST00000505472	SEC31A	chr4	83745827	-	1198	424	97	795	232
ENST00000405852	TANK	chr2	162061304	+	ENST00000500777	SEC31A	chr4	83745827	-	1198	424	97	795	232
ENST00000405852	TANK	chr2	162061304	+	ENST00000508502	SEC31A	chr4	83745827	-	859	424	97	795	232
ENST00000405852	TANK	chr2	162061304	+	ENST00000355196	SEC31A	chr4	83745827	-	859	424	97	795	232
ENST00000405852	TANK	chr2	162061304	+	ENST00000264405	SEC31A	chr4	83745827	-	848	424	97	795	232
ENST00000405852	TANK	chr2	162061304	+	ENST00000505984	SEC31A	chr4	83745827	-	826	424	97	795	232
ENST00000403609	TANK	chr2	162061304	+	ENST00000348405	SEC31A	chr4	83745827	-	1221	436	448	807	119
ENST00000403609	TANK	chr2	162061304	+	ENST00000513858	SEC31A	chr4	83745827	-	1221	436	448	807	119
ENST00000403609	TANK	chr2	162061304	+	ENST00000395310	SEC31A	chr4	83745827	-	1221	436	448	807	119
ENST00000403609	TANK	chr2	162061304	+	ENST00000443462	SEC31A	chr4	83745827	-	1220	436	448	807	119
ENST00000403609	TANK	chr2	162061304	+	ENST00000509142	SEC31A	chr4	83745827	-	1220	436	448	807	119
ENST00000403609	TANK	chr2	162061304	+	ENST00000326950	SEC31A	chr4	83745827	-	1220	436	448	807	119
ENST00000403609	TANK	chr2	162061304	+	ENST00000432794	SEC31A	chr4	83745827	-	1220	436	448	807	119
ENST00000403609	TANK	chr2	162061304	+	ENST00000311785	SEC31A	chr4	83745827	-	1220	436	448	807	119
ENST00000403609	TANK	chr2	162061304	+	ENST00000448323	SEC31A	chr4	83745827	-	1220	436	448	807	119
ENST00000403609	TANK	chr2	162061304	+	ENST00000505472	SEC31A	chr4	83745827	-	1210	436	448	807	119
ENST00000403609	TANK	chr2	162061304	+	ENST00000500777	SEC31A	chr4	83745827	-	1210	436	448	807	119
ENST00000403609	TANK	chr2	162061304	+	ENST00000508502	SEC31A	chr4	83745827	-	871	436	448	807	119
ENST00000403609	TANK	chr2	162061304	+	ENST00000355196	SEC31A	chr4	83745827	-	871	436	448	807	119
ENST00000403609	TANK	chr2	162061304	+	ENST00000264405	SEC31A	chr4	83745827	-	860	436	448	807	119
ENST00000403609	TANK	chr2	162061304	+	ENST00000505984	SEC31A	chr4	83745827	-	838	436	448	807	119

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000259075	ENST00000348405	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001089302	0.99891067
ENST00000259075	ENST00000513858	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001089302	0.99891067
ENST00000259075	ENST00000395310	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001089302	0.99891067
ENST00000259075	ENST00000443462	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001070945	0.9989291
ENST00000259075	ENST00000509142	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001070945	0.9989291
ENST00000259075	ENST00000326950	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001070945	0.9989291
ENST00000259075	ENST00000432794	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001070945	0.9989291
ENST00000259075	ENST00000311785	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001070945	0.9989291
ENST00000259075	ENST00000448323	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001070945	0.9989291
ENST00000259075	ENST00000505472	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001090808	0.99890924
ENST00000259075	ENST00000500777	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001090808	0.99890924
ENST00000259075	ENST00000508502	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.002615812	0.99738413
ENST00000259075	ENST00000355196	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.002615812	0.99738413
ENST00000259075	ENST00000264405	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.002443798	0.9975562
ENST00000259075	ENST00000505984	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.002972108	0.99702793
ENST00000457476	ENST00000348405	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.026295548	0.97370446
ENST00000457476	ENST00000513858	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.026295548	0.97370446
ENST00000457476	ENST00000395310	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.026295548	0.97370446
ENST00000457476	ENST00000443462	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.025521431	0.9744786
ENST00000457476	ENST00000509142	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.025521431	0.9744786
ENST00000457476	ENST00000326950	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.025521431	0.9744786
ENST00000457476	ENST00000432794	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.025521431	0.9744786
ENST00000457476	ENST00000311785	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.025521431	0.9744786
ENST00000457476	ENST00000448323	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.025521431	0.9744786
ENST00000457476	ENST00000505472	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.025630688	0.9743692
ENST00000457476	ENST00000500777	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.025630688	0.9743692
ENST00000457476	ENST00000508502	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.042484198	0.9575158
ENST00000457476	ENST00000355196	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.042484198	0.9575158
ENST00000457476	ENST00000264405	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.042179544	0.9578205
ENST00000457476	ENST00000505984	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.044207234	0.9557928
ENST00000392749	ENST00000348405	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001201609	0.9987984
ENST00000392749	ENST00000513858	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001201609	0.9987984
ENST00000392749	ENST00000395310	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001201609	0.9987984
ENST00000392749	ENST00000443462	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001183334	0.9988167
ENST00000392749	ENST00000509142	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001183334	0.9988167
ENST00000392749	ENST00000326950	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001183334	0.9988167
ENST00000392749	ENST00000432794	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001183334	0.9988167
ENST00000392749	ENST00000311785	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001183334	0.9988167
ENST00000392749	ENST00000448323	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001183334	0.9988167
ENST00000392749	ENST00000505472	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001204997	0.99879503
ENST00000392749	ENST00000500777	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001204997	0.99879503
ENST00000392749	ENST00000508502	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.00233613	0.99766386
ENST00000392749	ENST00000355196	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.00233613	0.99766386
ENST00000392749	ENST00000264405	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.002225689	0.9977743
ENST00000392749	ENST00000505984	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.002770638	0.9972294
ENST00000402568	ENST00000348405	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001470431	0.99852955
ENST00000402568	ENST00000513858	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001470431	0.99852955
ENST00000402568	ENST00000395310	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001470431	0.99852955
ENST00000402568	ENST00000443462	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001450862	0.99854916
ENST00000402568	ENST00000509142	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001450862	0.99854916
ENST00000402568	ENST00000326950	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001450862	0.99854916
ENST00000402568	ENST00000432794	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001450862	0.99854916
ENST00000402568	ENST00000311785	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001450862	0.99854916
ENST00000402568	ENST00000448323	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001450862	0.99854916
ENST00000402568	ENST00000505472	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001492031	0.9985079
ENST00000402568	ENST00000500777	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001492031	0.9985079
ENST00000402568	ENST00000508502	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.003379659	0.9966203
ENST00000402568	ENST00000355196	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.003379659	0.9966203
ENST00000402568	ENST00000264405	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.003251154	0.9967488
ENST00000402568	ENST00000505984	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.00405357	0.99594647
ENST00000406287	ENST00000348405	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.002100821	0.9978992
ENST00000406287	ENST00000513858	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.002100821	0.9978992
ENST00000406287	ENST00000395310	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.002100821	0.9978992
ENST00000406287	ENST00000443462	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.002070672	0.99792933
ENST00000406287	ENST00000509142	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.002070672	0.99792933
ENST00000406287	ENST00000326950	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.002070672	0.99792933
ENST00000406287	ENST00000432794	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.002070672	0.99792933
ENST00000406287	ENST00000311785	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.002070672	0.99792933
ENST00000406287	ENST00000448323	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.002070672	0.99792933
ENST00000406287	ENST00000505472	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.002118265	0.9978817
ENST00000406287	ENST00000500777	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.002118265	0.9978817
ENST00000406287	ENST00000508502	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.00492531	0.9950747
ENST00000406287	ENST00000355196	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.00492531	0.9950747
ENST00000406287	ENST00000264405	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.004710994	0.99528897
ENST00000406287	ENST00000505984	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.00581529	0.9941847
ENST00000405852	ENST00000348405	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.000947729	0.9990522
ENST00000405852	ENST00000513858	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.000947729	0.9990522
ENST00000405852	ENST00000395310	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.000947729	0.9990522
ENST00000405852	ENST00000443462	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.000932836	0.9990671
ENST00000405852	ENST00000509142	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.000932836	0.9990671
ENST00000405852	ENST00000326950	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.000932836	0.9990671
ENST00000405852	ENST00000432794	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.000932836	0.9990671
ENST00000405852	ENST00000311785	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.000932836	0.9990671
ENST00000405852	ENST00000448323	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.000932836	0.9990671
ENST00000405852	ENST00000505472	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.000947232	0.9990528
ENST00000405852	ENST00000500777	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.000947232	0.9990528
ENST00000405852	ENST00000508502	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001911899	0.99808806
ENST00000405852	ENST00000355196	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001911899	0.99808806
ENST00000405852	ENST00000264405	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.001763959	0.99823606
ENST00000405852	ENST00000505984	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.002174745	0.99782526
ENST00000403609	ENST00000348405	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.026372747	0.97362727
ENST00000403609	ENST00000513858	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.026372747	0.97362727
ENST00000403609	ENST00000395310	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.026372747	0.97362727
ENST00000403609	ENST00000443462	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.02634998	0.97365
ENST00000403609	ENST00000509142	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.02634998	0.97365
ENST00000403609	ENST00000326950	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.02634998	0.97365
ENST00000403609	ENST00000432794	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.02634998	0.97365
ENST00000403609	ENST00000311785	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.02634998	0.97365
ENST00000403609	ENST00000448323	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.02634998	0.97365
ENST00000403609	ENST00000505472	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.025150843	0.97484916
ENST00000403609	ENST00000500777	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.025150843	0.97484916
ENST00000403609	ENST00000508502	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.028846838	0.97115314
ENST00000403609	ENST00000355196	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.028846838	0.97115314
ENST00000403609	ENST00000264405	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.027438805	0.97256124
ENST00000403609	ENST00000505984	TANK	chr2	162061304	+	SEC31A	chr4	83745827	-	0.02979554	0.9702045

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for TANK-SEC31A

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
TANK	chr2	162061304	SEC31A	chr4	83745827	424	109	KVISGIAREKLPKHVQSLPTKKITKK
TANK	chr2	162061304	SEC31A	chr4	83745827	532	145	KVISGIAREKLPKHVQSLPTKKITKK
TANK	chr2	162061304	SEC31A	chr4	83745827	566	109	KVISGIAREKLPKHVQSLPTKKITKK
TANK	chr2	162061304	SEC31A	chr4	83745827	642	202	KVISGIAREKLPKHVQSLPTKKITKK
TANK	chr2	162061304	SEC31A	chr4	83745827	645	203	KVISGIAREKLPKHVQSLPTKKITKK

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Potential FusionNeoAntigen Information of TANK-SEC31A in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

TANK-SEC31A_162061304_83745827.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B14:02	LPKHVQSL	0.9977	0.7826	10	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B14:01	LPKHVQSL	0.9977	0.7826	10	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B08:09	LPKHVQSL	0.9945	0.6146	10	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B35:05	LPKHVQSL	0.9203	0.5497	10	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B35:04	LPKHVQSL	0.7578	0.9351	10	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B35:02	LPKHVQSL	0.7578	0.9351	10	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A02:22	KLPKHVQSL	0.9833	0.6735	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A02:27	KLPKHVQSL	0.9631	0.7634	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A02:13	KLPKHVQSL	0.9624	0.817	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A02:11	KLPKHVQSL	0.9602	0.7572	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A02:30	KLPKHVQSL	0.9596	0.7527	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A02:67	KLPKHVQSL	0.9596	0.7527	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A02:24	KLPKHVQSL	0.9596	0.7527	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A02:60	KLPKHVQSL	0.9581	0.7358	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A02:04	KLPKHVQSL	0.9449	0.6357	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A02:38	KLPKHVQSL	0.943	0.8153	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A02:16	KLPKHVQSL	0.9305	0.7465	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A02:21	KLPKHVQSL	0.921	0.8201	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B08:01	KLPKHVQSL	0.911	0.6473	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A32:13	KLPKHVQSL	0.8343	0.9522	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B08:09	KLPKHVQSL	0.8102	0.6884	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A02:35	KLPKHVQSL	0.8056	0.7465	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A02:29	KLPKHVQSL	0.8023	0.7515	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A02:20	KLPKHVQSL	0.7771	0.7526	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B07:10	KLPKHVQSL	0.6228	0.5917	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B13:02	KLPKHVQSL	0.0658	0.6701	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B13:01	KLPKHVQSL	0.0354	0.9902	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B14:02	EKLPKHVQSL	0.9825	0.9055	8	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B14:01	EKLPKHVQSL	0.9825	0.9055	8	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B08:01	EKLPKHVQSL	0.9563	0.6519	8	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A74:03	KHVQSLPTKK	0.4653	0.5006	12	22
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A74:09	KHVQSLPTKK	0.4653	0.5006	12	22
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A74:11	KHVQSLPTKK	0.4653	0.5006	12	22
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B48:01	REKLPKHVQSL	0.9998	0.6818	7	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B39:13	REKLPKHVQSL	0.9847	0.986	7	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B14:03	LPKHVQSL	0.9949	0.8	10	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B07:12	LPKHVQSL	0.9762	0.6725	10	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C01:30	LPKHVQSL	0.9663	0.9634	10	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C01:17	LPKHVQSL	0.9586	0.9698	10	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B35:12	LPKHVQSL	0.7578	0.9351	10	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B39:10	LPKHVQSL	0.6384	0.9573	10	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C12:04	KLPKHVQSL	0.9951	0.9937	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C06:03	KLPKHVQSL	0.9944	0.993	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C12:12	KLPKHVQSL	0.994	0.9283	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A02:05	KLPKHVQSL	0.9678	0.5573	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A02:01	KLPKHVQSL	0.9596	0.7527	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A02:07	KLPKHVQSL	0.9592	0.7418	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C15:06	KLPKHVQSL	0.9565	0.9314	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B42:02	KLPKHVQSL	0.9399	0.6336	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C04:10	KLPKHVQSL	0.9296	0.933	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C04:07	KLPKHVQSL	0.9241	0.9276	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C04:14	KLPKHVQSL	0.9107	0.9328	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C05:09	KLPKHVQSL	0.903	0.9449	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C01:17	KLPKHVQSL	0.9011	0.9703	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B15:04	KLPKHVQSL	0.892	0.9473	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C04:06	KLPKHVQSL	0.8915	0.9403	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B15:07	KLPKHVQSL	0.8748	0.7641	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B14:03	KLPKHVQSL	0.8687	0.8823	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C12:16	KLPKHVQSL	0.8265	0.9753	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B40:03	REKLPKHVQ	0.8238	0.6392	7	16
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C07:13	KLPKHVQSL	0.7559	0.9302	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C07:29	KLPKHVQSL	0.732	0.9575	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C07:10	KLPKHVQSL	0.7218	0.9653	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C02:06	KLPKHVQSL	0.7095	0.9581	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C07:05	KLPKHVQSL	0.7004	0.9616	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C07:80	KLPKHVQSL	0.6947	0.954	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C07:67	KLPKHVQSL	0.6947	0.954	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C01:30	KLPKHVQSL	0.6939	0.9723	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C07:19	KLPKHVQSL	0.6831	0.8336	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C07:27	KLPKHVQSL	0.5726	0.9612	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C07:46	KLPKHVQSL	0.551	0.9175	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C07:95	KLPKHVQSL	0.4712	0.7975	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B39:12	EKLPKHVQSL	0.9791	0.9732	8	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B14:03	EKLPKHVQSL	0.9449	0.9464	8	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C01:30	EKLPKHVQSL	0.9204	0.9749	8	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C01:17	REKLPKHVQSL	0.9988	0.9724	7	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B48:03	REKLPKHVQSL	0.9977	0.5571	7	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C01:30	REKLPKHVQSL	0.9974	0.9717	7	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B40:03	REKLPKHVQSL	0.997	0.5939	7	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B78:02	LPKHVQSL	0.9946	0.5428	10	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B08:12	LPKHVQSL	0.9543	0.7316	10	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C01:02	LPKHVQSL	0.9311	0.9693	10	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B35:17	LPKHVQSL	0.9193	0.7401	10	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B35:30	LPKHVQSL	0.9193	0.7401	10	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C01:03	LPKHVQSL	0.7797	0.9362	10	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B67:01	LPKHVQSL	0.7616	0.7177	10	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B35:09	LPKHVQSL	0.7578	0.9351	10	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C06:02	KLPKHVQSL	0.9939	0.9934	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C06:17	KLPKHVQSL	0.9939	0.9934	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A02:03	KLPKHVQSL	0.9843	0.7767	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C06:06	KLPKHVQSL	0.9794	0.9926	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C16:02	KLPKHVQSL	0.9651	0.993	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A32:01	KLPKHVQSL	0.965	0.9626	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B15:27	KLPKHVQSL	0.9509	0.9239	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C15:05	KLPKHVQSL	0.9442	0.923	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C18:01	KLPKHVQSL	0.9262	0.9247	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C04:01	KLPKHVQSL	0.9241	0.9276	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A02:14	KLPKHVQSL	0.924	0.7461	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A02:06	KLPKHVQSL	0.921	0.8201	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B08:18	KLPKHVQSL	0.911	0.6473	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C04:03	KLPKHVQSL	0.9095	0.9273	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C05:01	KLPKHVQSL	0.903	0.9449	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B15:35	KLPKHVQSL	0.8945	0.9178	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C04:04	KLPKHVQSL	0.893	0.9486	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C01:02	KLPKHVQSL	0.8865	0.9688	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C07:04	KLPKHVQSL	0.886	0.9732	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C14:03	KLPKHVQSL	0.8663	0.979	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C14:02	KLPKHVQSL	0.8663	0.979	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C03:17	KLPKHVQSL	0.8566	0.9719	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C03:67	KLPKHVQSL	0.8527	0.9823	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B15:73	KLPKHVQSL	0.821	0.9429	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C03:05	KLPKHVQSL	0.8041	0.9471	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C07:22	KLPKHVQSL	0.7899	0.8024	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C06:08	KLPKHVQSL	0.748	0.991	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C01:03	KLPKHVQSL	0.7208	0.9687	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C07:02	KLPKHVQSL	0.6947	0.954	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B08:12	KLPKHVQSL	0.6763	0.8139	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B15:30	KLPKHVQSL	0.6743	0.8729	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C07:17	KLPKHVQSL	0.6609	0.9677	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B07:13	KLPKHVQSL	0.5766	0.907	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C07:01	KLPKHVQSL	0.5444	0.7975	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C17:01	KLPKHVQSL	0.5165	0.9487	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C06:08	AREKLPKHV	0.475	0.9894	6	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B39:02	KLPKHVQSL	0.1524	0.957	9	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C06:02	AREKLPKHV	0.0093	0.9892	6	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C06:17	AREKLPKHV	0.0093	0.9892	6	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C01:02	EKLPKHVQSL	0.9668	0.9584	8	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B08:18	EKLPKHVQSL	0.9563	0.6519	8	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B08:12	EKLPKHVQSL	0.9428	0.8289	8	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A30:01	KHVQSLPTKK	0.8509	0.8907	12	22
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-A74:01	KHVQSLPTKK	0.4653	0.5006	12	22
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C01:03	REKLPKHVQSL	0.9994	0.9767	7	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B40:04	REKLPKHVQSL	0.9991	0.8335	7	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-C01:02	REKLPKHVQSL	0.9988	0.9725	7	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B40:12	REKLPKHVQSL	0.9977	0.5571	7	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B39:02	REKLPKHVQSL	0.9914	0.9851	7	18
TANK-SEC31A	chr2	162061304	chr4	83745827	532	HLA-B41:03	REKLPKHVQSL	0.9732	0.7946	7	18

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Potential FusionNeoAntigen Information of TANK-SEC31A in HLA II

TANK-SEC31A_162061304_83745827.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-0102	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-0102	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-0103	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-0109	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-0115	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-0123	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-0123	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-0825	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1113	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1117	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1152	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1189	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1201	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1201	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1201	KLPKHVQSLPTKKIT	9	24
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1203	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1203	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1203	KLPKHVQSLPTKKIT	9	24
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1204	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1204	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1205	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1205	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1205	KLPKHVQSLPTKKIT	9	24
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1206	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1206	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1206	KLPKHVQSLPTKKIT	9	24
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1207	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1207	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1207	KLPKHVQSLPTKKIT	9	24
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1208	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1208	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1208	KLPKHVQSLPTKKIT	9	24
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1209	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1209	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1210	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1210	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1210	KLPKHVQSLPTKKIT	9	24
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1211	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1211	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1211	KLPKHVQSLPTKKIT	9	24
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1212	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1212	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1212	KLPKHVQSLPTKKIT	9	24
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1213	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1213	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1213	KLPKHVQSLPTKKIT	9	24
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1214	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1214	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1214	KLPKHVQSLPTKKIT	9	24
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1215	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1215	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1215	KLPKHVQSLPTKKIT	9	24
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1216	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1216	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1216	KLPKHVQSLPTKKIT	9	24
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1217	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1217	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1217	KLPKHVQSLPTKKIT	9	24
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1218	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1218	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1218	KLPKHVQSLPTKKIT	9	24
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1219	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1219	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1219	KLPKHVQSLPTKKIT	9	24
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1220	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1220	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1220	KLPKHVQSLPTKKIT	9	24
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1221	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1221	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1221	KLPKHVQSLPTKKIT	9	24
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1222	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1222	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1223	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1223	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1223	KLPKHVQSLPTKKIT	9	24
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1354	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1377	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1377	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1401	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1404	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1405	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1408	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1411	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1418	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1423	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1426	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1428	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1431	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1432	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1434	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1435	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1438	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1443	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1445	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1450	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1452	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1454	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1455	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1456	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1457	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1458	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1459	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1460	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1461	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1462	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1464	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1465	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1470	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1471	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1472	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1475	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1481	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1482	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1486	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1487	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1488	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1490	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1491	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1495	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1496	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1497	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1499	KVISGIAREKLPKHV	0	15
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1503	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1504	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1510	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1521	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1523	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1615	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB1-1615	LPKHVQSLPTKKITK	10	25
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB5-0204	PKHVQSLPTKKITKK	11	26
TANK-SEC31A	chr2	162061304	chr4	83745827	532	DRB5-0205	PKHVQSLPTKKITKK	11	26

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Fusion breakpoint peptide structures of TANK-SEC31A

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
544	AREKLPKHVQSLPT	TANK	SEC31A	chr2	162061304	chr4	83745827	532

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of TANK-SEC31A

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	544	AREKLPKHVQSLPT	-5.16857	-5.28197
HLA-B14:02	3BVN	544	AREKLPKHVQSLPT	-4.21097	-5.24627
HLA-B52:01	3W39	544	AREKLPKHVQSLPT	-4.32839	-4.44179
HLA-B52:01	3W39	544	AREKLPKHVQSLPT	-4.10962	-5.14492
HLA-A24:02	5HGA	544	AREKLPKHVQSLPT	-6.03661	-6.15001
HLA-A24:02	5HGA	544	AREKLPKHVQSLPT	-5.99594	-7.03124
HLA-B44:05	3DX8	544	AREKLPKHVQSLPT	-6.27779	-6.39119
HLA-B44:05	3DX8	544	AREKLPKHVQSLPT	-4.76488	-5.80018

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Vaccine Design for the FusionNeoAntigens of TANK-SEC31A

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
TANK-SEC31A	chr2	162061304	chr4	83745827	10	18	LPKHVQSL	CTACCAAAGCATGTGCAGTCTTTG
TANK-SEC31A	chr2	162061304	chr4	83745827	12	22	KHVQSLPTKK	AAGCATGTGCAGTCTTTGCCAACAAAAAAA
TANK-SEC31A	chr2	162061304	chr4	83745827	6	15	AREKLPKHV	GCAAGAGAAAAACTACCAAAGCATGTG
TANK-SEC31A	chr2	162061304	chr4	83745827	7	16	REKLPKHVQ	AGAGAAAAACTACCAAAGCATGTGCAG
TANK-SEC31A	chr2	162061304	chr4	83745827	7	18	REKLPKHVQSL	AGAGAAAAACTACCAAAGCATGTGCAGTCTTTG
TANK-SEC31A	chr2	162061304	chr4	83745827	8	18	EKLPKHVQSL	GAAAAACTACCAAAGCATGTGCAGTCTTTG
TANK-SEC31A	chr2	162061304	chr4	83745827	9	18	KLPKHVQSL	AAACTACCAAAGCATGTGCAGTCTTTG

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
TANK-SEC31A	chr2	162061304	chr4	83745827	0	15	KVISGIAREKLPKHV	AAAGTGATTTCAGGAATAGCAAGAGAAAAACTACCAAAGCATGTG
TANK-SEC31A	chr2	162061304	chr4	83745827	10	25	LPKHVQSLPTKKITK	CTACCAAAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAG
TANK-SEC31A	chr2	162061304	chr4	83745827	11	26	PKHVQSLPTKKITKK	CCAAAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAA
TANK-SEC31A	chr2	162061304	chr4	83745827	9	24	KLPKHVQSLPTKKIT	AAACTACCAAAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACC

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Information of the samples that have these potential fusion neoantigens of TANK-SEC31A

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
STAD	TANK-SEC31A	chr2	162061304	ENST00000259075	chr4	83745827	ENST00000264405	TCGA-BR-A4J7-01A

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Potential target of CAR-T therapy development for TANK-SEC31A

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to TANK-SEC31A

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to TANK-SEC31A

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	SEC31A	C0079744	Diffuse Large B-Cell Lymphoma	1	CTD_human

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)