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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:TMPRSS2-ETV1

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TMPRSS2-ETV1
FusionPDB ID: 92378
FusionGDB2.0 ID: 92378
HgeneTgene
Gene symbol

TMPRSS2

ETV1

Gene ID

7113

2115

Gene nametransmembrane serine protease 2ETS variant transcription factor 1
SynonymsPP9284|PRSS10ER81
Cytomap

21q22.3

7p21.2

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2ETS translocation variant 1ETS variant 1ets variant gene 1ets-related protein 81
Modification date2020031320200313
UniProtAcc

O15393

Main function of 5'-partner protein: FUNCTION: Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity). {ECO:0000250|UniProtKB:Q9JIQ8, ECO:0000269|PubMed:15537383, ECO:0000269|PubMed:25122198, ECO:0000269|PubMed:26018085}.; FUNCTION: (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651, PubMed:32404436, PubMed:34159616, PubMed:33051876). Upon SARS-CoV-2 infection, increases syncytia formation by accelerating the fusion process (PubMed:34159616, PubMed:33051876). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity. {ECO:0000269|PubMed:21068237, ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651, ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32404436, ECO:0000269|PubMed:33051876, ECO:0000269|PubMed:34159616}.

P50549

Main function of 5'-partner protein: FUNCTION: Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' (PubMed:7651741). Required for olfactory dopaminergic neuron differentiation; may directly activate expression of tyrosine hydroxylase (TH) (By similarity). {ECO:0000250|UniProtKB:P41164, ECO:0000269|PubMed:7651741}.
Ensembl transtripts involved in fusion geneENST idsENST00000332149, ENST00000398585, 
ENST00000458356, ENST00000497881, 
ENST00000476720, ENST00000242066, 
ENST00000343495, ENST00000403527, 
ENST00000403685, ENST00000405192, 
ENST00000405218, ENST00000405358, 
ENST00000420159, ENST00000399357, 
ENST00000430479, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score40 X 73 X 10=2920013 X 27 X 6=2106
# samples 13030
** MAII scorelog2(130/29200*10)=-4.48938484073892
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/2106*10)=-2.81147103052984
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: TMPRSS2 [Title/Abstract] AND ETV1 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: TMPRSS2 [Title/Abstract] AND ETV1 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TMPRSS2(42880007)-ETV1(13978871), # samples:6
Anticipated loss of major functional domain due to fusion event.TMPRSS2-ETV1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-ETV1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-ETV1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-ETV1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-ETV1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TMPRSS2-ETV1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TMPRSS2-ETV1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TMPRSS2-ETV1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMPRSS2

GO:0006508

proteolysis

21068237|24227843

HgeneTMPRSS2

GO:0046598

positive regulation of viral entry into host cell

21068237|24227843

TgeneETV1

GO:0045944

positive regulation of transcription by RNA polymerase II

12750007



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:42880007/chr7:13978871)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across TMPRSS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ETV1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000458356TMPRSS2chr2142870045-ENST00000430479ETV1chr713971374-5622104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000399357ETV1chr713971374-5617104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000420159ETV1chr713971374-5617104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000343495ETV1chr713971374-5617104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000242066ETV1chr713971374-5617104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000405192ETV1chr713971374-3751104147914255
ENST00000458356TMPRSS2chr2142870045-ENST00000405358ETV1chr713971374-3582104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000403527ETV1chr713971374-2695104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000405218ETV1chr713971374-2469104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000403685ETV1chr713971374-992104147983278
ENST00000458356TMPRSS2chr2142870046-ENST00000430479ETV1chr713971374-5622104147983278
ENST00000458356TMPRSS2chr2142870046-ENST00000399357ETV1chr713971374-5617104147983278
ENST00000458356TMPRSS2chr2142870046-ENST00000420159ETV1chr713971374-5617104147983278
ENST00000458356TMPRSS2chr2142870046-ENST00000343495ETV1chr713971374-5617104147983278
ENST00000458356TMPRSS2chr2142870046-ENST00000242066ETV1chr713971374-5617104147983278
ENST00000458356TMPRSS2chr2142870046-ENST00000405192ETV1chr713971374-3751104147914255
ENST00000458356TMPRSS2chr2142870046-ENST00000405358ETV1chr713971374-3582104147983278
ENST00000458356TMPRSS2chr2142870046-ENST00000403527ETV1chr713971374-2695104147983278
ENST00000458356TMPRSS2chr2142870046-ENST00000405218ETV1chr713971374-2469104147983278
ENST00000458356TMPRSS2chr2142870046-ENST00000403685ETV1chr713971374-992104147983278
ENST00000332149TMPRSS2chr2142866283-ENST00000430479ETV1chr713950932-56433731351004289
ENST00000332149TMPRSS2chr2142866283-ENST00000399357ETV1chr713950932-56383731351004289
ENST00000332149TMPRSS2chr2142866283-ENST00000420159ETV1chr713950932-56383731351004289
ENST00000332149TMPRSS2chr2142866283-ENST00000343495ETV1chr713950932-56383731351004289
ENST00000332149TMPRSS2chr2142866283-ENST00000242066ETV1chr713950932-56383731351004289
ENST00000398585TMPRSS2chr2142866283-ENST00000430479ETV1chr713950932-5680410401041333
ENST00000398585TMPRSS2chr2142866283-ENST00000399357ETV1chr713950932-5675410401041333
ENST00000398585TMPRSS2chr2142866283-ENST00000420159ETV1chr713950932-5675410401041333
ENST00000398585TMPRSS2chr2142866283-ENST00000343495ETV1chr713950932-5675410401041333
ENST00000398585TMPRSS2chr2142866283-ENST00000242066ETV1chr713950932-5675410401041333
ENST00000458356TMPRSS2chr2142870045-ENST00000430479ETV1chr713971373-5622104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000399357ETV1chr713971373-5617104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000420159ETV1chr713971373-5617104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000343495ETV1chr713971373-5617104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000242066ETV1chr713971373-5617104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000405192ETV1chr713971373-3751104147914255
ENST00000458356TMPRSS2chr2142870045-ENST00000405358ETV1chr713971373-3582104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000403527ETV1chr713971373-2695104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000405218ETV1chr713971373-2469104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000403685ETV1chr713971373-992104147983278
ENST00000332149TMPRSS2chr2142866282-ENST00000430479ETV1chr713950931-56433731351004289
ENST00000332149TMPRSS2chr2142866282-ENST00000399357ETV1chr713950931-56383731351004289
ENST00000332149TMPRSS2chr2142866282-ENST00000420159ETV1chr713950931-56383731351004289
ENST00000332149TMPRSS2chr2142866282-ENST00000343495ETV1chr713950931-56383731351004289
ENST00000332149TMPRSS2chr2142866282-ENST00000242066ETV1chr713950931-56383731351004289
ENST00000398585TMPRSS2chr2142866282-ENST00000430479ETV1chr713950931-5680410401041333
ENST00000398585TMPRSS2chr2142866282-ENST00000399357ETV1chr713950931-5675410401041333
ENST00000398585TMPRSS2chr2142866282-ENST00000420159ETV1chr713950931-5675410401041333
ENST00000398585TMPRSS2chr2142866282-ENST00000343495ETV1chr713950931-5675410401041333
ENST00000398585TMPRSS2chr2142866282-ENST00000242066ETV1chr713950931-5675410401041333

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000458356ENST00000430479TMPRSS2chr2142870045-ETV1chr713971374-0.0001846660.9998154
ENST00000458356ENST00000399357TMPRSS2chr2142870045-ETV1chr713971374-0.0001859540.9998141
ENST00000458356ENST00000420159TMPRSS2chr2142870045-ETV1chr713971374-0.0001859540.9998141
ENST00000458356ENST00000343495TMPRSS2chr2142870045-ETV1chr713971374-0.0001859540.9998141
ENST00000458356ENST00000242066TMPRSS2chr2142870045-ETV1chr713971374-0.0001859540.9998141
ENST00000458356ENST00000405192TMPRSS2chr2142870045-ETV1chr713971374-0.0005252120.9994748
ENST00000458356ENST00000405358TMPRSS2chr2142870045-ETV1chr713971374-0.000165090.9998349
ENST00000458356ENST00000403527TMPRSS2chr2142870045-ETV1chr713971374-0.000230480.9997695
ENST00000458356ENST00000405218TMPRSS2chr2142870045-ETV1chr713971374-0.0002359360.999764
ENST00000458356ENST00000403685TMPRSS2chr2142870045-ETV1chr713971374-0.0004075490.9995925
ENST00000458356ENST00000430479TMPRSS2chr2142870046-ETV1chr713971374-0.0001846660.9998154
ENST00000458356ENST00000399357TMPRSS2chr2142870046-ETV1chr713971374-0.0001859540.9998141
ENST00000458356ENST00000420159TMPRSS2chr2142870046-ETV1chr713971374-0.0001859540.9998141
ENST00000458356ENST00000343495TMPRSS2chr2142870046-ETV1chr713971374-0.0001859540.9998141
ENST00000458356ENST00000242066TMPRSS2chr2142870046-ETV1chr713971374-0.0001859540.9998141
ENST00000458356ENST00000405192TMPRSS2chr2142870046-ETV1chr713971374-0.0005252120.9994748
ENST00000458356ENST00000405358TMPRSS2chr2142870046-ETV1chr713971374-0.000165090.9998349
ENST00000458356ENST00000403527TMPRSS2chr2142870046-ETV1chr713971374-0.000230480.9997695
ENST00000458356ENST00000405218TMPRSS2chr2142870046-ETV1chr713971374-0.0002359360.999764
ENST00000458356ENST00000403685TMPRSS2chr2142870046-ETV1chr713971374-0.0004075490.9995925
ENST00000332149ENST00000430479TMPRSS2chr2142866283-ETV1chr713950932-0.0001762110.99982387
ENST00000332149ENST00000399357TMPRSS2chr2142866283-ETV1chr713950932-0.0001769950.99982303
ENST00000332149ENST00000420159TMPRSS2chr2142866283-ETV1chr713950932-0.0001769950.99982303
ENST00000332149ENST00000343495TMPRSS2chr2142866283-ETV1chr713950932-0.0001769950.99982303
ENST00000332149ENST00000242066TMPRSS2chr2142866283-ETV1chr713950932-0.0001769950.99982303
ENST00000398585ENST00000430479TMPRSS2chr2142866283-ETV1chr713950932-0.0001126230.99988735
ENST00000398585ENST00000399357TMPRSS2chr2142866283-ETV1chr713950932-0.0001125550.99988747
ENST00000398585ENST00000420159TMPRSS2chr2142866283-ETV1chr713950932-0.0001125550.99988747
ENST00000398585ENST00000343495TMPRSS2chr2142866283-ETV1chr713950932-0.0001125550.99988747
ENST00000398585ENST00000242066TMPRSS2chr2142866283-ETV1chr713950932-0.0001125550.99988747
ENST00000458356ENST00000430479TMPRSS2chr2142870045-ETV1chr713971373-0.0001846660.9998154
ENST00000458356ENST00000399357TMPRSS2chr2142870045-ETV1chr713971373-0.0001859540.9998141
ENST00000458356ENST00000420159TMPRSS2chr2142870045-ETV1chr713971373-0.0001859540.9998141
ENST00000458356ENST00000343495TMPRSS2chr2142870045-ETV1chr713971373-0.0001859540.9998141
ENST00000458356ENST00000242066TMPRSS2chr2142870045-ETV1chr713971373-0.0001859540.9998141
ENST00000458356ENST00000405192TMPRSS2chr2142870045-ETV1chr713971373-0.0005252120.9994748
ENST00000458356ENST00000405358TMPRSS2chr2142870045-ETV1chr713971373-0.000165090.9998349
ENST00000458356ENST00000403527TMPRSS2chr2142870045-ETV1chr713971373-0.000230480.9997695
ENST00000458356ENST00000405218TMPRSS2chr2142870045-ETV1chr713971373-0.0002359360.999764
ENST00000458356ENST00000403685TMPRSS2chr2142870045-ETV1chr713971373-0.0004075490.9995925
ENST00000332149ENST00000430479TMPRSS2chr2142866282-ETV1chr713950931-0.0001762110.99982387
ENST00000332149ENST00000399357TMPRSS2chr2142866282-ETV1chr713950931-0.0001769950.99982303
ENST00000332149ENST00000420159TMPRSS2chr2142866282-ETV1chr713950931-0.0001769950.99982303
ENST00000332149ENST00000343495TMPRSS2chr2142866282-ETV1chr713950931-0.0001769950.99982303
ENST00000332149ENST00000242066TMPRSS2chr2142866282-ETV1chr713950931-0.0001769950.99982303
ENST00000398585ENST00000430479TMPRSS2chr2142866282-ETV1chr713950931-0.0001126230.99988735
ENST00000398585ENST00000399357TMPRSS2chr2142866282-ETV1chr713950931-0.0001125550.99988747
ENST00000398585ENST00000420159TMPRSS2chr2142866282-ETV1chr713950931-0.0001125550.99988747
ENST00000398585ENST00000343495TMPRSS2chr2142866282-ETV1chr713950931-0.0001125550.99988747
ENST00000398585ENST00000242066TMPRSS2chr2142866282-ETV1chr713950931-0.0001125550.99988747

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for TMPRSS2-ETV1

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
TMPRSS2chr2142866282ETV1chr71395093137378CTQPKSPSGTVCTSKVPSCHSIYMRQ
TMPRSS2chr2142866282ETV1chr713950931410122CTQPKSPSGTVCTSKVPSCHSIYMRQ
TMPRSS2chr2142866283ETV1chr71395093237378CTQPKSPSGTVCTSKVPSCHSIYMRQ
TMPRSS2chr2142866283ETV1chr713950932410122CTQPKSPSGTVCTSKVPSCHSIYMRQ

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Potential FusionNeoAntigen Information of TMPRSS2-ETV1 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Potential FusionNeoAntigen Information of TMPRSS2-ETV1 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of TMPRSS2-ETV1

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of TMPRSS2-ETV1

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score

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Vaccine Design for the FusionNeoAntigens of TMPRSS2-ETV1

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of TMPRSS2-ETV1

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample

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Potential target of CAR-T therapy development for TMPRSS2-ETV1

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42866282chr7:13950931ENST00000398585-31485_105116530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42866283chr7:13950932ENST00000398585-31485_105116530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to TMPRSS2-ETV1

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TMPRSS2-ETV1

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTMPRSS2C0033578Prostatic Neoplasms4CTD_human
HgeneTMPRSS2C0376358Malignant neoplasm of prostate4CTD_human
TgeneETV1C0033578Prostatic Neoplasms3CTD_human
TgeneETV1C0376358Malignant neoplasm of prostate3CTD_human
TgeneETV1C0009402Colorectal Carcinoma1CTD_human
TgeneETV1C0009404Colorectal Neoplasms1CTD_human