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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:BCAS4-PTPN1

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: BCAS4-PTPN1
FusionPDB ID: 9259
FusionGDB2.0 ID: 9259
HgeneTgene
Gene symbol

BCAS4

PTPN1

Gene ID

55653

5770

Gene namebreast carcinoma amplified sequence 4protein tyrosine phosphatase non-receptor type 1
SynonymsCNOLPTP1B
Cytomap

20q13.13

20q13.13

Type of geneprotein-codingprotein-coding
Descriptionbreast carcinoma-amplified sequence 4BCAS4/BCAS3 fusionbreast carcinoma amplified sequence 4/3 fusion proteintyrosine-protein phosphatase non-receptor type 1protein tyrosine phosphatase, placentalprotein-tyrosine phosphatase 1B
Modification date2020031320200329
UniProtAcc

Q8TDM0

Main function of 5'-partner protein:

Q99952

Main function of 5'-partner protein: FUNCTION: Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
Ensembl transtripts involved in fusion geneENST idsENST00000485049, ENST00000262591, 
ENST00000358791, ENST00000371608, 
ENST00000609336, 		ENST00000371621, 
ENST00000541713, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 15 X 10=225014 X 14 X 5=980
# samples 2119
** MAII scorelog2(21/2250*10)=-3.42146376843828
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/980*10)=-2.36678233067162
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: BCAS4 [Title/Abstract] AND PTPN1 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: BCAS4 [Title/Abstract] AND PTPN1 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)BCAS4(49458437)-PTPN1(49194957), # samples:2
PTPN1(49127127)-BCAS4(49434748), # samples:2
Anticipated loss of major functional domain due to fusion event.BCAS4-PTPN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BCAS4-PTPN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BCAS4-PTPN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BCAS4-PTPN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPN1-BCAS4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPN1-BCAS4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BCAS4-PTPN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
BCAS4-PTPN1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
BCAS4-PTPN1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePTPN1

GO:0030100

regulation of endocytosis

21135139

TgenePTPN1

GO:0030968

endoplasmic reticulum unfolded protein response

22169477

TgenePTPN1

GO:0035335

peptidyl-tyrosine dephosphorylation

21135139

TgenePTPN1

GO:0061098

positive regulation of protein tyrosine kinase activity

21216966

TgenePTPN1

GO:1903898

negative regulation of PERK-mediated unfolded protein response

21216966



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:49458437/chr20:49194957)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across BCAS4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PTPN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358791BCAS4chr2049458437+ENST00000371621PTPN1chr2049194956+3452589341404456
ENST00000358791BCAS4chr2049458437+ENST00000541713PTPN1chr2049194956+1675589341404456
ENST00000371608BCAS4chr2049458437+ENST00000371621PTPN1chr2049194956+335248901304434
ENST00000371608BCAS4chr2049458437+ENST00000541713PTPN1chr2049194956+157548901304434
ENST00000609336BCAS4chr2049458437+ENST00000371621PTPN1chr2049194956+3315452501267405
ENST00000609336BCAS4chr2049458437+ENST00000541713PTPN1chr2049194956+1538452501267405
ENST00000358791BCAS4chr2049458437+ENST00000371621PTPN1chr2049194957+3452589341404456
ENST00000358791BCAS4chr2049458437+ENST00000541713PTPN1chr2049194957+1675589341404456
ENST00000371608BCAS4chr2049458437+ENST00000371621PTPN1chr2049194957+335248901304434
ENST00000371608BCAS4chr2049458437+ENST00000541713PTPN1chr2049194957+157548901304434
ENST00000609336BCAS4chr2049458437+ENST00000371621PTPN1chr2049194957+3315452501267405
ENST00000609336BCAS4chr2049458437+ENST00000541713PTPN1chr2049194957+1538452501267405
ENST00000358791BCAS4chr2049446917-ENST00000371621PTPN1chr2049177900+3746454341698554
ENST00000262591BCAS4chr2049446917-ENST00000371621PTPN1chr2049177900+371041841662552
ENST00000371608BCAS4chr2049446917-ENST00000371621PTPN1chr2049177900+364635401598532
ENST00000609336BCAS4chr2049446917-ENST00000371621PTPN1chr2049177900+3609317501561503

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358791ENST00000371621BCAS4chr2049458437+PTPN1chr2049194956+0.0043846090.99561536
ENST00000358791ENST00000541713BCAS4chr2049458437+PTPN1chr2049194956+0.0175401980.9824598
ENST00000371608ENST00000371621BCAS4chr2049458437+PTPN1chr2049194956+0.0037970020.996203
ENST00000371608ENST00000541713BCAS4chr2049458437+PTPN1chr2049194956+0.0164127130.9835873
ENST00000609336ENST00000371621BCAS4chr2049458437+PTPN1chr2049194956+0.0034810710.99651897
ENST00000609336ENST00000541713BCAS4chr2049458437+PTPN1chr2049194956+0.0141529250.98584706
ENST00000358791ENST00000371621BCAS4chr2049458437+PTPN1chr2049194957+0.0043846090.99561536
ENST00000358791ENST00000541713BCAS4chr2049458437+PTPN1chr2049194957+0.0175401980.9824598
ENST00000371608ENST00000371621BCAS4chr2049458437+PTPN1chr2049194957+0.0037970020.996203
ENST00000371608ENST00000541713BCAS4chr2049458437+PTPN1chr2049194957+0.0164127130.9835873
ENST00000609336ENST00000371621BCAS4chr2049458437+PTPN1chr2049194957+0.0034810710.99651897
ENST00000609336ENST00000541713BCAS4chr2049458437+PTPN1chr2049194957+0.0141529250.98584706
ENST00000358791ENST00000371621BCAS4chr2049446917-PTPN1chr2049177900+0.0021794620.9978205
ENST00000262591ENST00000371621BCAS4chr2049446917-PTPN1chr2049177900+0.0021621590.99783784
ENST00000371608ENST00000371621BCAS4chr2049446917-PTPN1chr2049177900+0.0019498530.9980501
ENST00000609336ENST00000371621BCAS4chr2049446917-PTPN1chr2049177900+0.0010190620.99898094

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for BCAS4-PTPN1

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
BCAS4chr2049446917PTPN1chr204917790031787LTEMRGIYAKVDRLEDIRHEASDFPC
BCAS4chr2049446917PTPN1chr2049177900354116LTEMRGIYAKVDRLEDIRHEASDFPC
BCAS4chr2049446917PTPN1chr2049177900418136LTEMRGIYAKVDRLEDIRHEASDFPC
BCAS4chr2049446917PTPN1chr2049177900454138LTEMRGIYAKVDRLEDIRHEASDFPC
BCAS4chr2049458437PTPN1chr2049194956452134RWLGSAGLPSFRNTQETREILHFHYT
BCAS4chr2049458437PTPN1chr2049194956489163RWLGSAGLPSFRNTQETREILHFHYT
BCAS4chr2049458437PTPN1chr2049194956589185RWLGSAGLPSFRNTQETREILHFHYT
BCAS4chr2049458437PTPN1chr2049194957452134RWLGSAGLPSFRNTQETREILHFHYT
BCAS4chr2049458437PTPN1chr2049194957489163RWLGSAGLPSFRNTQETREILHFHYT
BCAS4chr2049458437PTPN1chr2049194957589185RWLGSAGLPSFRNTQETREILHFHYT

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Potential FusionNeoAntigen Information of BCAS4-PTPN1 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
BCAS4-PTPN1_49446917_49177900.msa
BCAS4-PTPN1_49458437_49194956.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
BCAS4-PTPN1chr2049446917chr2049177900418HLA-A02:38GIYAKVDRL0.94630.6887514
BCAS4-PTPN1chr2049446917chr2049177900418HLA-B39:06DRLEDIRHEA0.99680.83281121
BCAS4-PTPN1chr2049446917chr2049177900418HLA-B73:01DRLEDIRHEA0.9980.72561121
BCAS4-PTPN1chr2049446917chr2049177900418HLA-C14:03IYAKVDRL0.81510.9223614
BCAS4-PTPN1chr2049446917chr2049177900418HLA-C14:02IYAKVDRL0.81510.9223614
BCAS4-PTPN1chr2049446917chr2049177900418HLA-A02:03GIYAKVDRL0.95210.5367514
BCAS4-PTPN1chr2049458437chr2049194956589HLA-C06:17FRNTQETREI0.78230.9921020
BCAS4-PTPN1chr2049458437chr2049194956589HLA-C06:02FRNTQETREI0.78230.9921020

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Potential FusionNeoAntigen Information of BCAS4-PTPN1 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
BCAS4-PTPN1_49446917_49177900.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0801RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0801MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0801EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0801GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0801TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0802RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0802MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0803RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0803MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0803EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0803GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0803TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0805RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0805MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0805EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0805GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0805TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0806MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0806RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0806EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0807RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0807MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0808RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0808MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0808EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0808GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0809RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0809MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0810MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0810RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0810EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0811RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0811MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0811EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0811GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0812MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0812RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0812EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0813RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0813MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0814RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0814MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0814EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0814GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0814TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0815RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0815MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0816RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0816MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0816EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0816GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0816TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0818RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0818MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0818EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0818GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0818TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0821RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0821MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0822MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0822RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0822EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0823RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0823MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0823EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0823GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0823TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0824RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0824MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0825RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0825MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0826RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0826MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0826EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0826GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0826TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0827RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0827MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0827EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0827GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0827TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0829RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0829MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0829EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0829GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0829TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0830RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0830MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0832RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0832MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0832EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0833RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0833MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0833EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0833GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0833TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0835RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0835MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0835EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0835GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0835TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0836RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0836MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0836EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0836GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0836TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0837RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0837MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0837EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0837GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0838RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0838MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0838EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0838GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0838TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0839RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0839MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0839EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0839GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0839TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0840RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0840MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0840EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0840GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-0840TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1101RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1101MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1105RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1105MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1108RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1108MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1109RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1109MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1110RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1110MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1112RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1112MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1115RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1115MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1119RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1119MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1124RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1124MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1127RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1127MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1128RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1128MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1129RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1129MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1131RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1131MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1132RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1132MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1133RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1133MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1137RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1137MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1139RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1139MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1145RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1145MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1149RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1149MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1151RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1151MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1153RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1153MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1154RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1154MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1161RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1161MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1162RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1162MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1164RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1164MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1166RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1166MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1169RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1169MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1172RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1172MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1173RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1173MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1174RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1174MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1175RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1175MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1179RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1180RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1180MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1181RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1181MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1182RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1187RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1187MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1190RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1190MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1191RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1191MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1193RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1193MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1194RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1194MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1195RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1195MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1196RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1196MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1303RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1303MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1303EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1303GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1303TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1305RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1305MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1307RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1307MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-13100RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-13100MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-13100EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-13101RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-13101MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-13101EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-13101GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-13101TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1310RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1310MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1310EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1310GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1310TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1312RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1312MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1312EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1312GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1312TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1313RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1313MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1313EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1313GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1313TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1314RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1314MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1321RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1321MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1321EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1321GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1321TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1326RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1330RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1330MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1330EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1330GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1330TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1333RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1333MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1333EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1333GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1337RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1337MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1338RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1338MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1338EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1338GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1346RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1346MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1346EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1347RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1347MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1349RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1349MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1349EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1349GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1349TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1350RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1350MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1355RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1355MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1355EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1355GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1355TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1356RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1356MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1358MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1358RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1360RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1360MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1362RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1362MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1365RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1365MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1365EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1365GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1366RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1366MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1366EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1366GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1366TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1382RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1382MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1385RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1385MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1386RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1388RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1388MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1388EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1388GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1388TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1390RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1390MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1390EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1390GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1390TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1395RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1395MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1395EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1395GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1395TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1402RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1403RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1403MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1407RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1407MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1409RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1409MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1413RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1413MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1413EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1413GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1414RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1414MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1422RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1422MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1422EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1422GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1425RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1425MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1425EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1425GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1427RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1430RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1430MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1436RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1436MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1440RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1440MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1441RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1442RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1442MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1444RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1444MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1449RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1449MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1451RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1451MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1453RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1453MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1453EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1453GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1457MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1457EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1457TEMRGIYAKVDRLED116
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1457RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1463RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1463MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1463EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1463GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1467RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1467MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1468RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1468MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1469RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1469MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1469EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1469GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1473RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1473MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1477RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1477MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1478MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1478RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1485RGIYAKVDRLEDIRH419
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1485MRGIYAKVDRLEDIR318
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1485EMRGIYAKVDRLEDI217
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1485GIYAKVDRLEDIRHE520
BCAS4-PTPN1chr2049446917chr2049177900418DRB1-1494RGIYAKVDRLEDIRH419

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Fusion breakpoint peptide structures of BCAS4-PTPN1

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
2949GLPSFRNTQETREIBCAS4PTPN1chr2049458437chr2049194956589
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
4070IYAKVDRLEDIRHEBCAS4PTPN1chr2049446917chr2049177900418

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of BCAS4-PTPN1

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN2949GLPSFRNTQETREI-8.55667-8.74867
HLA-B14:023BVN2949GLPSFRNTQETREI-3.49457-4.25557
HLA-B52:013W392949GLPSFRNTQETREI-7.26725-7.45925
HLA-B52:013W392949GLPSFRNTQETREI-4.01461-4.77561
HLA-A24:025HGA2949GLPSFRNTQETREI-7.65911-8.42011
HLA-A24:025HGA2949GLPSFRNTQETREI-7.10204-7.29404
HLA-B44:053DX82949GLPSFRNTQETREI-7.5556-8.3166
HLA-B44:053DX82949GLPSFRNTQETREI-2.76159-2.95359
HLA-B14:023BVN4070IYAKVDRLEDIRHE-7.9962-8.1096
HLA-B14:023BVN4070IYAKVDRLEDIRHE-5.70842-6.74372
HLA-B52:013W394070IYAKVDRLEDIRHE-6.83737-6.95077
HLA-B52:013W394070IYAKVDRLEDIRHE-4.4836-5.5189
HLA-A11:014UQ24070IYAKVDRLEDIRHE-10.0067-10.1201
HLA-A11:014UQ24070IYAKVDRLEDIRHE-9.03915-10.0745
HLA-A24:025HGA4070IYAKVDRLEDIRHE-6.56204-6.67544
HLA-A24:025HGA4070IYAKVDRLEDIRHE-5.42271-6.45801
HLA-B44:053DX84070IYAKVDRLEDIRHE-7.85648-8.89178
HLA-B44:053DX84070IYAKVDRLEDIRHE-5.3978-5.5112
HLA-A02:016TDR4070IYAKVDRLEDIRHE-3.37154-4.40684

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Vaccine Design for the FusionNeoAntigens of BCAS4-PTPN1

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
BCAS4-PTPN1chr2049446917chr20491779001121DRLEDIRHEACTAGAGGATATCCGACATGAAGCCAGTGAC
BCAS4-PTPN1chr2049446917chr2049177900514GIYAKVDRLTATGCCAAAGTGGACCGGCTAGAGGAT
BCAS4-PTPN1chr2049446917chr2049177900614IYAKVDRLGCCAAAGTGGACCGGCTAGAGGAT
BCAS4-PTPN1chr2049458437chr20491949561020FRNTQETREITTCAGGAACACCCAAGAAACTCGAGAGATC

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
BCAS4-PTPN1chr2049446917chr2049177900116TEMRGIYAKVDRLEDATGCGTGGCATCTATGCCAAAGTGGACCGGCTAGAGGATATCCGA
BCAS4-PTPN1chr2049446917chr2049177900217EMRGIYAKVDRLEDICGTGGCATCTATGCCAAAGTGGACCGGCTAGAGGATATCCGACAT
BCAS4-PTPN1chr2049446917chr2049177900318MRGIYAKVDRLEDIRGGCATCTATGCCAAAGTGGACCGGCTAGAGGATATCCGACATGAA
BCAS4-PTPN1chr2049446917chr2049177900419RGIYAKVDRLEDIRHATCTATGCCAAAGTGGACCGGCTAGAGGATATCCGACATGAAGCC
BCAS4-PTPN1chr2049446917chr2049177900520GIYAKVDRLEDIRHETATGCCAAAGTGGACCGGCTAGAGGATATCCGACATGAAGCCAGT

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Information of the samples that have these potential fusion neoantigens of BCAS4-PTPN1

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
UCECBCAS4-PTPN1chr2049446917ENST00000262591chr2049177900ENST00000371621TCGA-A5-A2K4-01A
BRCABCAS4-PTPN1chr2049458437ENST00000358791chr2049194956ENST00000371621TCGA-A8-A07W

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Potential target of CAR-T therapy development for BCAS4-PTPN1

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to BCAS4-PTPN1

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to BCAS4-PTPN1

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource