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Fusion Protein:UCK2-PBX1

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: UCK2-PBX1
	FusionPDB ID: 96569
	FusionGDB2.0 ID: 96569
		Hgene	Tgene
	Gene symbol	UCK2	PBX1
	Gene ID	7371	5087
	Gene name	uridine-cytidine kinase 2	PBX homeobox 1
	Synonyms	TSA903\|UK\|UMPK	CAKUHED
	Cytomap	1q24.1	1q23.3
	Type of gene	protein-coding	protein-coding
	Description	uridine-cytidine kinase 2cytidine monophosphokinase 2testis-specific protein TSA903uridine kinaseuridine monophosphate kinaseuridine monophosphokinase 2	pre-B-cell leukemia transcription factor 1homeobox protein PBX1homeobox protein PRLpre-B-cell leukemia homeobox 1
	Modification date	20200313	20200313
	UniProtAcc	.	P40424 Main function of 5'-partner protein: FUNCTION: Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8 (PubMed:9191052). Binds to the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein (PubMed:9191052). Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4 (PubMed:8327485, PubMed:7791786). Acts as a transcriptional activator of PF4 in complex with MEIS1 (PubMed:12609849). Also activates transcription of SOX3 in complex with MEIS1 by binding to the 5'-TGATTGAC-3' consensus sequence (By similarity). In natural killer cells, binds to the NFIL3 promoter and acts as a transcriptional activator of NFIL3, promoting natural killer cell development (By similarity). Plays a role in the cAMP-dependent regulation of CYP17A1 gene expression via its cAMP-regulatory sequence (CRS1) (By similarity). Probably in complex with MEIS2, involved in transcriptional regulation by KLF4 (PubMed:21746878). Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B (By similarity). Together with NKX2-5, required for spleen development through a mechanism that involves CDKN2B repression (By similarity). {ECO:0000250\|UniProtKB:P41778, ECO:0000269\|PubMed:12609849, ECO:0000269\|PubMed:21746878, ECO:0000269\|PubMed:7791786, ECO:0000269\|PubMed:8327485, ECO:0000269\|PubMed:9191052}.; FUNCTION: [Isoform PBX1b]: As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. {ECO:0000250\|UniProtKB:P41778}.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000372212, ENST00000462329, ENST00000367879, ENST00000469256, ENST00000470820,	ENST00000367897, ENST00000401534, ENST00000420696, ENST00000540236, ENST00000559240, ENST00000560641, ENST00000474046, ENST00000485769, ENST00000540246,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	17 X 9 X 9=1377	13 X 13 X 8=1352
	# samples	20	17
	** MAII score	log2(20/1377*10)=-2.78345665436024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/1352*10)=-2.99148850014448 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: UCK2 [Title/Abstract] AND PBX1 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: UCK2 [Title/Abstract] AND PBX1 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	UCK2(165797169)-PBX1(164761731), # samples:3 UCK2(165860559)-PBX1(164532475), # samples:3
Anticipated loss of major functional domain due to fusion event.	UCK2-PBX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. UCK2-PBX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. UCK2-PBX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. UCK2-PBX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. UCK2-PBX1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. UCK2-PBX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. UCK2-PBX1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. UCK2-PBX1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:165797169/chr1:164761731)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across UCK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PBX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000367879	UCK2	chr1	165860559	+	ENST00000420696	PBX1	chr1	164532475	+	6916	659	120	1760	546
ENST00000367879	UCK2	chr1	165860559	+	ENST00000401534	PBX1	chr1	164532475	+	1512	659	120	1511	463
ENST00000367879	UCK2	chr1	165860559	+	ENST00000559240	PBX1	chr1	164532475	+	1488	659	120	1487	455
ENST00000367879	UCK2	chr1	165860559	+	ENST00000367897	PBX1	chr1	164532475	+	1927	659	120	1511	463
ENST00000367879	UCK2	chr1	165860559	+	ENST00000540236	PBX1	chr1	164532475	+	1731	659	120	1730	536
ENST00000372212	UCK2	chr1	165860559	+	ENST00000420696	PBX1	chr1	164532475	+	6625	368	12	1469	485
ENST00000372212	UCK2	chr1	165860559	+	ENST00000401534	PBX1	chr1	164532475	+	1221	368	12	1220	402
ENST00000372212	UCK2	chr1	165860559	+	ENST00000559240	PBX1	chr1	164532475	+	1197	368	12	1196	394
ENST00000372212	UCK2	chr1	165860559	+	ENST00000367897	PBX1	chr1	164532475	+	1636	368	12	1220	402
ENST00000372212	UCK2	chr1	165860559	+	ENST00000540236	PBX1	chr1	164532475	+	1440	368	12	1439	475
ENST00000367879	UCK2	chr1	165875206	+	ENST00000420696	PBX1	chr1	164761731	+	7132	949	120	1976	618
ENST00000367879	UCK2	chr1	165875206	+	ENST00000401534	PBX1	chr1	164761731	+	1728	949	120	1727	535
ENST00000367879	UCK2	chr1	165875206	+	ENST00000559240	PBX1	chr1	164761731	+	1704	949	120	1703	527
ENST00000367879	UCK2	chr1	165875206	+	ENST00000367897	PBX1	chr1	164761731	+	2143	949	120	1727	535
ENST00000367879	UCK2	chr1	165875206	+	ENST00000540236	PBX1	chr1	164761731	+	1947	949	120	1946	608
ENST00000469256	UCK2	chr1	165875206	+	ENST00000420696	PBX1	chr1	164761731	+	6545	362	46	1389	447
ENST00000469256	UCK2	chr1	165875206	+	ENST00000401534	PBX1	chr1	164761731	+	1141	362	46	1140	365
ENST00000469256	UCK2	chr1	165875206	+	ENST00000559240	PBX1	chr1	164761731	+	1117	362	46	1116	357
ENST00000469256	UCK2	chr1	165875206	+	ENST00000367897	PBX1	chr1	164761731	+	1556	362	46	1140	364
ENST00000469256	UCK2	chr1	165875206	+	ENST00000540236	PBX1	chr1	164761731	+	1360	362	46	1359	438
ENST00000470820	UCK2	chr1	165875206	+	ENST00000420696	PBX1	chr1	164761731	+	7078	895	486	1922	478
ENST00000470820	UCK2	chr1	165875206	+	ENST00000401534	PBX1	chr1	164761731	+	1674	895	486	1673	395
ENST00000470820	UCK2	chr1	165875206	+	ENST00000559240	PBX1	chr1	164761731	+	1650	895	486	1649	387
ENST00000470820	UCK2	chr1	165875206	+	ENST00000367897	PBX1	chr1	164761731	+	2089	895	486	1673	395
ENST00000470820	UCK2	chr1	165875206	+	ENST00000540236	PBX1	chr1	164761731	+	1893	895	486	1892	468
ENST00000367879	UCK2	chr1	165875206	+	ENST00000420696	PBX1	chr1	164761730	+	7132	949	120	1976	618
ENST00000367879	UCK2	chr1	165875206	+	ENST00000401534	PBX1	chr1	164761730	+	1728	949	120	1727	535
ENST00000367879	UCK2	chr1	165875206	+	ENST00000559240	PBX1	chr1	164761730	+	1704	949	120	1703	527
ENST00000367879	UCK2	chr1	165875206	+	ENST00000367897	PBX1	chr1	164761730	+	2143	949	120	1727	535
ENST00000367879	UCK2	chr1	165875206	+	ENST00000540236	PBX1	chr1	164761730	+	1947	949	120	1946	608
ENST00000469256	UCK2	chr1	165875206	+	ENST00000420696	PBX1	chr1	164761730	+	6545	362	46	1389	447
ENST00000469256	UCK2	chr1	165875206	+	ENST00000401534	PBX1	chr1	164761730	+	1141	362	46	1140	365
ENST00000469256	UCK2	chr1	165875206	+	ENST00000559240	PBX1	chr1	164761730	+	1117	362	46	1116	357
ENST00000469256	UCK2	chr1	165875206	+	ENST00000367897	PBX1	chr1	164761730	+	1556	362	46	1140	364
ENST00000469256	UCK2	chr1	165875206	+	ENST00000540236	PBX1	chr1	164761730	+	1360	362	46	1359	438
ENST00000470820	UCK2	chr1	165875206	+	ENST00000420696	PBX1	chr1	164761730	+	7078	895	486	1922	478
ENST00000470820	UCK2	chr1	165875206	+	ENST00000401534	PBX1	chr1	164761730	+	1674	895	486	1673	395
ENST00000470820	UCK2	chr1	165875206	+	ENST00000559240	PBX1	chr1	164761730	+	1650	895	486	1649	387
ENST00000470820	UCK2	chr1	165875206	+	ENST00000367897	PBX1	chr1	164761730	+	2089	895	486	1673	395
ENST00000470820	UCK2	chr1	165875206	+	ENST00000540236	PBX1	chr1	164761730	+	1893	895	486	1892	468

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000367879	ENST00000420696	UCK2	chr1	165860559	+	PBX1	chr1	164532475	+	0.000442707	0.9995573
ENST00000367879	ENST00000401534	UCK2	chr1	165860559	+	PBX1	chr1	164532475	+	0.011094844	0.9889052
ENST00000367879	ENST00000559240	UCK2	chr1	165860559	+	PBX1	chr1	164532475	+	0.011788014	0.9882119
ENST00000367879	ENST00000367897	UCK2	chr1	165860559	+	PBX1	chr1	164532475	+	0.010191212	0.9898088
ENST00000367879	ENST00000540236	UCK2	chr1	165860559	+	PBX1	chr1	164532475	+	0.01254032	0.98745966
ENST00000372212	ENST00000420696	UCK2	chr1	165860559	+	PBX1	chr1	164532475	+	0.00036031	0.99963963
ENST00000372212	ENST00000401534	UCK2	chr1	165860559	+	PBX1	chr1	164532475	+	0.00930879	0.9906911
ENST00000372212	ENST00000559240	UCK2	chr1	165860559	+	PBX1	chr1	164532475	+	0.011464474	0.9885356
ENST00000372212	ENST00000367897	UCK2	chr1	165860559	+	PBX1	chr1	164532475	+	0.007313381	0.9926866
ENST00000372212	ENST00000540236	UCK2	chr1	165860559	+	PBX1	chr1	164532475	+	0.008832778	0.99116725
ENST00000367879	ENST00000420696	UCK2	chr1	165875206	+	PBX1	chr1	164761731	+	0.000648029	0.9993519
ENST00000367879	ENST00000401534	UCK2	chr1	165875206	+	PBX1	chr1	164761731	+	0.009056424	0.9909436
ENST00000367879	ENST00000559240	UCK2	chr1	165875206	+	PBX1	chr1	164761731	+	0.011111524	0.98888844
ENST00000367879	ENST00000367897	UCK2	chr1	165875206	+	PBX1	chr1	164761731	+	0.008600568	0.9913994
ENST00000367879	ENST00000540236	UCK2	chr1	165875206	+	PBX1	chr1	164761731	+	0.011906476	0.98809355
ENST00000469256	ENST00000420696	UCK2	chr1	165875206	+	PBX1	chr1	164761731	+	0.000269572	0.9997304
ENST00000469256	ENST00000401534	UCK2	chr1	165875206	+	PBX1	chr1	164761731	+	0.003246534	0.9967534
ENST00000469256	ENST00000559240	UCK2	chr1	165875206	+	PBX1	chr1	164761731	+	0.006349677	0.9936504
ENST00000469256	ENST00000367897	UCK2	chr1	165875206	+	PBX1	chr1	164761731	+	0.003815085	0.9961849
ENST00000469256	ENST00000540236	UCK2	chr1	165875206	+	PBX1	chr1	164761731	+	0.003664547	0.9963354
ENST00000470820	ENST00000420696	UCK2	chr1	165875206	+	PBX1	chr1	164761731	+	0.000265239	0.9997347
ENST00000470820	ENST00000401534	UCK2	chr1	165875206	+	PBX1	chr1	164761731	+	0.00145708	0.9985429
ENST00000470820	ENST00000559240	UCK2	chr1	165875206	+	PBX1	chr1	164761731	+	0.002792577	0.99720746
ENST00000470820	ENST00000367897	UCK2	chr1	165875206	+	PBX1	chr1	164761731	+	0.001934989	0.99806505
ENST00000470820	ENST00000540236	UCK2	chr1	165875206	+	PBX1	chr1	164761731	+	0.001994549	0.99800545
ENST00000367879	ENST00000420696	UCK2	chr1	165875206	+	PBX1	chr1	164761730	+	0.000648029	0.9993519
ENST00000367879	ENST00000401534	UCK2	chr1	165875206	+	PBX1	chr1	164761730	+	0.009056424	0.9909436
ENST00000367879	ENST00000559240	UCK2	chr1	165875206	+	PBX1	chr1	164761730	+	0.011111524	0.98888844
ENST00000367879	ENST00000367897	UCK2	chr1	165875206	+	PBX1	chr1	164761730	+	0.008600568	0.9913994
ENST00000367879	ENST00000540236	UCK2	chr1	165875206	+	PBX1	chr1	164761730	+	0.011906476	0.98809355
ENST00000469256	ENST00000420696	UCK2	chr1	165875206	+	PBX1	chr1	164761730	+	0.000269572	0.9997304
ENST00000469256	ENST00000401534	UCK2	chr1	165875206	+	PBX1	chr1	164761730	+	0.003246534	0.9967534
ENST00000469256	ENST00000559240	UCK2	chr1	165875206	+	PBX1	chr1	164761730	+	0.006349677	0.9936504
ENST00000469256	ENST00000367897	UCK2	chr1	165875206	+	PBX1	chr1	164761730	+	0.003815085	0.9961849
ENST00000469256	ENST00000540236	UCK2	chr1	165875206	+	PBX1	chr1	164761730	+	0.003664547	0.9963354
ENST00000470820	ENST00000420696	UCK2	chr1	165875206	+	PBX1	chr1	164761730	+	0.000265239	0.9997347
ENST00000470820	ENST00000401534	UCK2	chr1	165875206	+	PBX1	chr1	164761730	+	0.00145708	0.9985429
ENST00000470820	ENST00000559240	UCK2	chr1	165875206	+	PBX1	chr1	164761730	+	0.002792577	0.99720746
ENST00000470820	ENST00000367897	UCK2	chr1	165875206	+	PBX1	chr1	164761730	+	0.001934989	0.99806505
ENST00000470820	ENST00000540236	UCK2	chr1	165875206	+	PBX1	chr1	164761730	+	0.001994549	0.99800545

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for UCK2-PBX1

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
UCK2	chr1	165860559	PBX1	chr1	164532475	368	118	TVQIPVYDFVSHSRKHALNCHRMKPA
UCK2	chr1	165860559	PBX1	chr1	164532475	659	179	TVQIPVYDFVSHSRKHALNCHRMKPA
UCK2	chr1	165875206	PBX1	chr1	164761730	362	105	YADVIIPRGADNLVLSIRGAQEEEPT
UCK2	chr1	165875206	PBX1	chr1	164761730	895	136	YADVIIPRGADNLVLSIRGAQEEEPT
UCK2	chr1	165875206	PBX1	chr1	164761730	949	276	YADVIIPRGADNLVLSIRGAQEEEPT
UCK2	chr1	165875206	PBX1	chr1	164761731	362	105	YADVIIPRGADNLVLSIRGAQEEEPT
UCK2	chr1	165875206	PBX1	chr1	164761731	895	136	YADVIIPRGADNLVLSIRGAQEEEPT
UCK2	chr1	165875206	PBX1	chr1	164761731	949	276	YADVIIPRGADNLVLSIRGAQEEEPT

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Potential FusionNeoAntigen Information of UCK2-PBX1 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

UCK2-PBX1_165860559_164532475.msa
UCK2-PBX1_165875206_164761730.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B39:01	SHSRKHAL	0.9973	0.8716	10	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B08:01	SHSRKHAL	0.9892	0.5103	10	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B38:02	SHSRKHAL	0.9791	0.9653	10	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B38:01	SHSRKHAL	0.9767	0.9735	10	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B14:01	SHSRKHAL	0.9619	0.576	10	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B14:02	SHSRKHAL	0.9619	0.576	10	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B15:37	SHSRKHAL	0.7825	0.5332	10	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B08:01	VSHSRKHAL	0.9945	0.5792	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B08:09	VSHSRKHAL	0.9908	0.6384	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-A30:08	HSRKHALNC	0.9394	0.7782	11	20
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B14:01	VSHSRKHAL	0.9047	0.6033	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B14:02	VSHSRKHAL	0.9047	0.6033	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B08:01	FVSHSRKHAL	0.9948	0.5974	8	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B39:09	SHSRKHAL	0.9981	0.5071	10	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B39:12	SHSRKHAL	0.9964	0.8848	10	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B39:05	SHSRKHAL	0.9779	0.8557	10	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B14:03	SHSRKHAL	0.8151	0.8243	10	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C15:04	VSHSRKHAL	0.9948	0.8705	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C03:19	VSHSRKHAL	0.9911	0.9782	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C03:07	VSHSRKHAL	0.991	0.9449	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C03:08	VSHSRKHAL	0.989	0.8973	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C12:12	VSHSRKHAL	0.9826	0.8763	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C15:06	VSHSRKHAL	0.9741	0.916	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B42:02	VSHSRKHAL	0.9731	0.5423	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C06:03	VSHSRKHAL	0.9686	0.9814	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B42:01	VSHSRKHAL	0.9571	0.5431	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C12:04	VSHSRKHAL	0.9564	0.9781	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C04:10	VYDFVSHSR	0.8764	0.7182	5	14
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C04:07	VYDFVSHSR	0.871	0.712	5	14
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B14:03	VSHSRKHAL	0.7315	0.8571	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C02:06	VSHSRKHAL	0.6163	0.8988	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C08:13	VSHSRKHAL	0.602	0.9247	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C08:04	VSHSRKHAL	0.602	0.9247	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C07:05	VSHSRKHAL	0.5611	0.9401	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C03:14	VSHSRKHAL	0.4306	0.9651	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C01:17	VSHSRKHAL	0.3902	0.951	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C01:30	VSHSRKHAL	0.3448	0.9657	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C04:14	VYDFVSHSR	0.3171	0.7076	5	14
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B39:31	SHSRKHAL	0.9936	0.8797	10	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B08:18	SHSRKHAL	0.9892	0.5103	10	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B08:12	SHSRKHAL	0.9801	0.6526	10	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B38:05	SHSRKHAL	0.9767	0.9735	10	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B39:11	SHSRKHAL	0.7367	0.7767	10	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C15:09	VSHSRKHAL	0.9948	0.8705	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B08:18	VSHSRKHAL	0.9945	0.5792	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C03:04	VSHSRKHAL	0.9904	0.9834	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C03:03	VSHSRKHAL	0.9904	0.9834	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C03:05	VSHSRKHAL	0.9886	0.89	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C03:17	VSHSRKHAL	0.9875	0.9389	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C15:02	VSHSRKHAL	0.9797	0.8881	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C03:67	VSHSRKHAL	0.9781	0.9733	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C12:03	VSHSRKHAL	0.9771	0.9482	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C15:05	VSHSRKHAL	0.9666	0.9026	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C03:02	VSHSRKHAL	0.9237	0.9245	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C16:04	VSHSRKHAL	0.8996	0.9572	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C12:02	VSHSRKHAL	0.8775	0.9433	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C04:01	VYDFVSHSR	0.871	0.712	5	14
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C07:04	VSHSRKHAL	0.862	0.9386	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B08:12	VSHSRKHAL	0.8372	0.6923	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C06:06	VSHSRKHAL	0.7672	0.9875	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C03:06	VSHSRKHAL	0.703	0.982	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C16:01	VSHSRKHAL	0.6773	0.976	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B07:13	VSHSRKHAL	0.6615	0.8091	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C16:02	VSHSRKHAL	0.5476	0.992	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C01:02	VSHSRKHAL	0.4037	0.9519	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-C01:03	VSHSRKHAL	0.174	0.9292	9	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B08:18	FVSHSRKHAL	0.9948	0.5974	8	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	HLA-B08:12	FVSHSRKHAL	0.9418	0.7146	8	18
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-B35:03	IPRGADNLVL	0.8343	0.7597	5	15
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-B35:04	IPRGADNLVL	0.6148	0.8597	5	15
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-B35:02	IPRGADNLVL	0.6148	0.8597	5	15
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-C05:09	GADNLVLSI	0.9999	0.9021	8	17
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-C08:15	GADNLVLSI	0.9997	0.9507	8	17
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-C04:06	GADNLVLSI	0.9852	0.7269	8	17
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-B07:12	IPRGADNLV	0.8837	0.5047	5	14
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-C08:04	GADNLVLSI	0.8019	0.9173	8	17
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-C08:13	GADNLVLSI	0.8019	0.9173	8	17
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-C08:03	GADNLVLSI	0.5101	0.95	8	17
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-C02:06	GADNLVLSI	0.4936	0.9301	8	17
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-B42:01	IPRGADNLV	0.2747	0.6088	5	14
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-B07:12	IPRGADNLVL	0.9958	0.5895	5	15
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-B42:02	IPRGADNLVL	0.8781	0.7389	5	15
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-B42:01	IPRGADNLVL	0.8646	0.7337	5	15
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-B39:10	IPRGADNLVL	0.6275	0.9118	5	15
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-B35:12	IPRGADNLVL	0.6148	0.8597	5	15
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-C04:03	GADNLVLSI	0.9999	0.7838	8	17
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-C05:01	GADNLVLSI	0.9999	0.9021	8	17
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-C08:02	GADNLVLSI	0.9997	0.9507	8	17
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-C15:05	GADNLVLSI	0.9949	0.8809	8	17
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-C15:02	GADNLVLSI	0.9948	0.8543	8	17
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-C17:01	GADNLVLSI	0.7311	0.9083	8	17
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-B55:04	IPRGADNLV	0.6135	0.5261	5	14
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-B35:13	GADNLVLSI	0.5528	0.8088	8	17
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-C08:01	GADNLVLSI	0.5101	0.95	8	17
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-B67:01	IPRGADNLV	0.0822	0.8192	5	14
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-B07:13	GADNLVLSI	0.0713	0.8243	8	17
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-B35:13	IPRGADNLVL	0.8201	0.7722	5	15
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-B35:09	IPRGADNLVL	0.6148	0.8597	5	15
UCK2-PBX1	chr1	165875206	chr1	164761730	949	HLA-B67:01	IPRGADNLVL	0.5953	0.8078	5	15

Top

Potential FusionNeoAntigen Information of UCK2-PBX1 in HLA II

UCK2-PBX1_165860559_164532475.msa
UCK2-PBX1_165875206_164761730.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1111	PVYDFVSHSRKHALN	4	19
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1111	VYDFVSHSRKHALNC	5	20
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1111	IPVYDFVSHSRKHAL	3	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1114	PVYDFVSHSRKHALN	4	19
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1114	VYDFVSHSRKHALNC	5	20
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1114	IPVYDFVSHSRKHAL	3	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1120	PVYDFVSHSRKHALN	4	19
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1120	VYDFVSHSRKHALNC	5	20
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1120	IPVYDFVSHSRKHAL	3	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1168	PVYDFVSHSRKHALN	4	19
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1169	PVYDFVSHSRKHALN	4	19
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1186	PVYDFVSHSRKHALN	4	19
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1186	IPVYDFVSHSRKHAL	3	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1302	PVYDFVSHSRKHALN	4	19
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1302	VYDFVSHSRKHALNC	5	20
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1302	IPVYDFVSHSRKHAL	3	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1316	PVYDFVSHSRKHALN	4	19
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1316	IPVYDFVSHSRKHAL	3	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1323	PVYDFVSHSRKHALN	4	19
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1323	VYDFVSHSRKHALNC	5	20
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1323	IPVYDFVSHSRKHAL	3	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1329	PVYDFVSHSRKHALN	4	19
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1334	PVYDFVSHSRKHALN	4	19
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1334	VYDFVSHSRKHALNC	5	20
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1334	IPVYDFVSHSRKHAL	3	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1336	PVYDFVSHSRKHALN	4	19
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1336	VYDFVSHSRKHALNC	5	20
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1336	IPVYDFVSHSRKHAL	3	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1339	PVYDFVSHSRKHALN	4	19
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1339	VYDFVSHSRKHALNC	5	20
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1339	IPVYDFVSHSRKHAL	3	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1341	PVYDFVSHSRKHALN	4	19
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1363	PVYDFVSHSRKHALN	4	19
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1363	VYDFVSHSRKHALNC	5	20
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1363	IPVYDFVSHSRKHAL	3	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1373	PVYDFVSHSRKHALN	4	19
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1373	VYDFVSHSRKHALNC	5	20
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1373	IPVYDFVSHSRKHAL	3	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1374	PVYDFVSHSRKHALN	4	19
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1374	VYDFVSHSRKHALNC	5	20
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1374	IPVYDFVSHSRKHAL	3	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1396	PVYDFVSHSRKHALN	4	19
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1397	PVYDFVSHSRKHALN	4	19
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1397	VYDFVSHSRKHALNC	5	20
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1397	IPVYDFVSHSRKHAL	3	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1399	PVYDFVSHSRKHALN	4	19
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1399	VYDFVSHSRKHALNC	5	20
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1399	IPVYDFVSHSRKHAL	3	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB1-1510	QIPVYDFVSHSRKHA	2	17
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0103	QIPVYDFVSHSRKHA	2	17
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0103	VQIPVYDFVSHSRKH	1	16
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0106	QIPVYDFVSHSRKHA	2	17
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0106	VQIPVYDFVSHSRKH	1	16
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0106	TVQIPVYDFVSHSRK	0	15
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0106	IPVYDFVSHSRKHAL	3	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0111	QIPVYDFVSHSRKHA	2	17
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0111	VQIPVYDFVSHSRKH	1	16
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0202	QIPVYDFVSHSRKHA	2	17
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0202	VQIPVYDFVSHSRKH	1	16
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0202	TVQIPVYDFVSHSRK	0	15
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0202	IPVYDFVSHSRKHAL	3	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0203	QIPVYDFVSHSRKHA	2	17
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0203	VQIPVYDFVSHSRKH	1	16
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0203	IPVYDFVSHSRKHAL	3	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0203	TVQIPVYDFVSHSRK	0	15
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0204	QIPVYDFVSHSRKHA	2	17
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0204	VQIPVYDFVSHSRKH	1	16
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0204	TVQIPVYDFVSHSRK	0	15
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0204	IPVYDFVSHSRKHAL	3	18
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0205	QIPVYDFVSHSRKHA	2	17
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0205	VQIPVYDFVSHSRKH	1	16
UCK2-PBX1	chr1	165860559	chr1	164532475	659	DRB5-0205	TVQIPVYDFVSHSRK	0	15
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-0804	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-0806	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-0820	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-0820	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-0828	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-0831	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1101	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1104	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1104	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1106	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1106	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1108	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1109	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1110	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1112	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1115	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1117	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1117	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1118	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1118	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1124	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1125	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1125	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1127	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1128	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1129	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1133	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1134	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1135	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1135	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1138	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1138	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1139	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1141	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1142	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1142	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1143	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1143	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1144	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1144	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1146	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1146	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1147	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1147	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1149	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1150	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1150	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1151	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1152	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1152	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1153	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1153	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1154	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1154	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1154	DNLVLSIRGAQEEEP	10	25
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1154	RGADNLVLSIRGAQE	7	22
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1156	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1156	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1157	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1157	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1158	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1158	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1160	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1160	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1161	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1162	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1166	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1167	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1173	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1174	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1175	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1177	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1177	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1178	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1178	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1180	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1181	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1183	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1183	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1184	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1184	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1187	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1188	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1188	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1189	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1189	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1189	DNLVLSIRGAQEEEP	10	25
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1190	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1191	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1192	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1193	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1194	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1195	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1196	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1305	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1306	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1306	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1311	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1311	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1314	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1318	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1318	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1337	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1342	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1342	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1344	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1347	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1350	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1356	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1358	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1362	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1375	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1376	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1381	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1389	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1405	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1405	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1408	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1408	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1411	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1412	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1415	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1417	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1418	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1418	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1421	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1423	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1423	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1433	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1433	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1442	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1443	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1443	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1445	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1445	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1456	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1456	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1459	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1459	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1464	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1464	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1472	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1472	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1473	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1478	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1484	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1484	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1491	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1491	GADNLVLSIRGAQEE	8	23
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1495	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1496	ADNLVLSIRGAQEEE	9	24
UCK2-PBX1	chr1	165875206	chr1	164761730	949	DRB1-1496	GADNLVLSIRGAQEE	8	23

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Fusion breakpoint peptide structures of UCK2-PBX1

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
6943	PRGADNLVLSIRGA	UCK2	PBX1	chr1	165875206	chr1	164761730	949

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
10600	YDFVSHSRKHALNC	UCK2	PBX1	chr1	165860559	chr1	164532475	659

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of UCK2-PBX1

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	6943	PRGADNLVLSIRGA	-6.73843	-6.85183
HLA-B14:02	3BVN	6943	PRGADNLVLSIRGA	-4.57748	-5.61278
HLA-B52:01	3W39	6943	PRGADNLVLSIRGA	-5.80453	-5.91793
HLA-B52:01	3W39	6943	PRGADNLVLSIRGA	-5.49348	-6.52878
HLA-A24:02	5HGA	6943	PRGADNLVLSIRGA	-7.27634	-7.38974
HLA-A24:02	5HGA	6943	PRGADNLVLSIRGA	-4.8067	-5.842
HLA-B27:05	6PYJ	6943	PRGADNLVLSIRGA	-6.57527	-6.68867
HLA-B44:05	3DX8	6943	PRGADNLVLSIRGA	-5.79513	-5.90853
HLA-B44:05	3DX8	6943	PRGADNLVLSIRGA	-3.57845	-4.61375
HLA-A02:01	6TDR	6943	PRGADNLVLSIRGA	-3.4602	-3.5736
HLA-B14:02	3BVN	10600	YDFVSHSRKHALNC	-7.15543	-7.26883
HLA-B14:02	3BVN	10600	YDFVSHSRKHALNC	-4.77435	-5.80965
HLA-B52:01	3W39	10600	YDFVSHSRKHALNC	-6.80875	-6.92215
HLA-B52:01	3W39	10600	YDFVSHSRKHALNC	-4.20386	-5.23916
HLA-A11:01	4UQ2	10600	YDFVSHSRKHALNC	-7.5194	-8.5547
HLA-A11:01	4UQ2	10600	YDFVSHSRKHALNC	-6.9601	-7.0735
HLA-A24:02	5HGA	10600	YDFVSHSRKHALNC	-7.52403	-7.63743
HLA-A24:02	5HGA	10600	YDFVSHSRKHALNC	-5.82433	-6.85963
HLA-B27:05	6PYJ	10600	YDFVSHSRKHALNC	-3.28285	-4.31815
HLA-B44:05	3DX8	10600	YDFVSHSRKHALNC	-5.91172	-6.94702
HLA-B44:05	3DX8	10600	YDFVSHSRKHALNC	-4.24346	-4.35686

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Vaccine Design for the FusionNeoAntigens of UCK2-PBX1

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
UCK2-PBX1	chr1	165860559	chr1	164532475	10	18	SHSRKHAL	CCATTCCCGAAAACATGCTTTAAA
UCK2-PBX1	chr1	165860559	chr1	164532475	11	20	HSRKHALNC	TTCCCGAAAACATGCTTTAAACTGCCA
UCK2-PBX1	chr1	165860559	chr1	164532475	5	14	VYDFVSHSR	GTATGACTTTGTCTCCCATTCCCGAAA
UCK2-PBX1	chr1	165860559	chr1	164532475	8	18	FVSHSRKHAL	TGTCTCCCATTCCCGAAAACATGCTTTAAA
UCK2-PBX1	chr1	165860559	chr1	164532475	9	18	VSHSRKHAL	CTCCCATTCCCGAAAACATGCTTTAAA
UCK2-PBX1	chr1	165875206	chr1	164761730	5	14	IPRGADNLV	TCCCTAGAGGTGCAGATAATCTGGTTT
UCK2-PBX1	chr1	165875206	chr1	164761730	5	15	IPRGADNLVL	TCCCTAGAGGTGCAGATAATCTGGTTTTGA
UCK2-PBX1	chr1	165875206	chr1	164761730	8	17	GADNLVLSI	GTGCAGATAATCTGGTTTTGAGTATCC

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
UCK2-PBX1	chr1	165860559	chr1	164532475	0	15	TVQIPVYDFVSHSRK	AGTCCAGATCCCCGTGTATGACTTTGTCTCCCATTCCCGAAAACA
UCK2-PBX1	chr1	165860559	chr1	164532475	1	16	VQIPVYDFVSHSRKH	CCAGATCCCCGTGTATGACTTTGTCTCCCATTCCCGAAAACATGC
UCK2-PBX1	chr1	165860559	chr1	164532475	2	17	QIPVYDFVSHSRKHA	GATCCCCGTGTATGACTTTGTCTCCCATTCCCGAAAACATGCTTT
UCK2-PBX1	chr1	165860559	chr1	164532475	3	18	IPVYDFVSHSRKHAL	CCCCGTGTATGACTTTGTCTCCCATTCCCGAAAACATGCTTTAAA
UCK2-PBX1	chr1	165860559	chr1	164532475	4	19	PVYDFVSHSRKHALN	CGTGTATGACTTTGTCTCCCATTCCCGAAAACATGCTTTAAACTG
UCK2-PBX1	chr1	165860559	chr1	164532475	5	20	VYDFVSHSRKHALNC	GTATGACTTTGTCTCCCATTCCCGAAAACATGCTTTAAACTGCCA
UCK2-PBX1	chr1	165875206	chr1	164761730	10	25	DNLVLSIRGAQEEEP	ATAATCTGGTTTTGAGTATCCGAGGAGCCCAGGAGGAGGAACCCA
UCK2-PBX1	chr1	165875206	chr1	164761730	7	22	RGADNLVLSIRGAQE	GAGGTGCAGATAATCTGGTTTTGAGTATCCGAGGAGCCCAGGAGG
UCK2-PBX1	chr1	165875206	chr1	164761730	8	23	GADNLVLSIRGAQEE	GTGCAGATAATCTGGTTTTGAGTATCCGAGGAGCCCAGGAGGAGG
UCK2-PBX1	chr1	165875206	chr1	164761730	9	24	ADNLVLSIRGAQEEE	CAGATAATCTGGTTTTGAGTATCCGAGGAGCCCAGGAGGAGGAAC

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Information of the samples that have these potential fusion neoantigens of UCK2-PBX1

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
SARC	UCK2-PBX1	chr1	165860559	ENST00000367879	chr1	164532475	ENST00000367897	TCGA-X6-A8C6-01A
STAD	UCK2-PBX1	chr1	165875206	ENST00000367879	chr1	164761730	ENST00000367897	TCGA-VQ-A92D

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Potential target of CAR-T therapy development for UCK2-PBX1

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to UCK2-PBX1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to UCK2-PBX1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	PBX1	C0006413	Burkitt Lymphoma	2	CTD_human;ORPHANET
Tgene	PBX1	C0343640	African Burkitt's lymphoma	2	CTD_human
Tgene	PBX1	C1968949	Cakut	2	GENOMICS_ENGLAND
Tgene	PBX1	C4721444	Burkitt Leukemia	2	CTD_human
Tgene	PBX1	C0013146	Drug abuse	1	CTD_human
Tgene	PBX1	C0013170	Drug habituation	1	CTD_human
Tgene	PBX1	C0013222	Drug Use Disorders	1	CTD_human
Tgene	PBX1	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
Tgene	PBX1	C0038580	Substance Dependence	1	CTD_human
Tgene	PBX1	C0038586	Substance Use Disorders	1	CTD_human
Tgene	PBX1	C0236969	Substance-Related Disorders	1	CTD_human
Tgene	PBX1	C0431692	Bilateral renal hypoplasia	1	ORPHANET
Tgene	PBX1	C0740858	Substance abuse problem	1	CTD_human
Tgene	PBX1	C1510472	Drug Dependence	1	CTD_human
Tgene	PBX1	C4316881	Prescription Drug Abuse	1	CTD_human
Tgene	PBX1	C4539968	CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT SYNDROME WITH OR WITHOUT HEARING LOSS, ABNORMAL EARS, OR DEVELOPMENTAL DELAY	1	GENOMICS_ENGLAND

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)