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Fusion Protein:BIRC6-LTBP1 |
Fusion Gene and Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: BIRC6-LTBP1 | FusionPDB ID: 9759 | FusionGDB2.0 ID: 9759 | Hgene | Tgene | Gene symbol | BIRC6 | LTBP1 | Gene ID | 57448 | 4052 |
Gene name | baculoviral IAP repeat containing 6 | latent transforming growth factor beta binding protein 1 | |
Synonyms | APOLLON|BRUCE | - | |
Cytomap | 2p22.3 | 2p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | baculoviral IAP repeat-containing protein 6BIR repeat-containing ubiquitin-conjugating enzymeRING-type E3 ubiquitin transferase BIRC6ubiquitin-conjugating BIR-domain enzyme apollon | latent-transforming growth factor beta-binding protein 1LTBP-1TGF-beta1-BP-1transforming growth factor beta-1-binding protein 1 | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | Q9NR09 Main function of 5'-partner protein: FUNCTION: Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369}. | Q14766 Main function of 5'-partner protein: FUNCTION: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000421745, | ENST00000272273, ENST00000498013, ENST00000354476, ENST00000390003, ENST00000402934, ENST00000404525, ENST00000404816, ENST00000407925, ENST00000418533, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 21 X 23 X 16=7728 | 13 X 14 X 6=1092 |
# samples | 33 | 14 | |
** MAII score | log2(33/7728*10)=-4.54955716458996 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/1092*10)=-2.96347412397489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Fusion gene context | PubMed: BIRC6 [Title/Abstract] AND LTBP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Fusion neoantigen context | PubMed: BIRC6 [Title/Abstract] AND LTBP1 [Title/Abstract] AND neoantigen [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | LTBP1(33246273)-BIRC6(32631567), # samples:8 BIRC6(32756618)-LTBP1(33442618), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | BIRC6-LTBP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BIRC6-LTBP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BIRC6-LTBP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BIRC6-LTBP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LTBP1-BIRC6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LTBP1-BIRC6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LTBP1-BIRC6 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. LTBP1-BIRC6 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. LTBP1-BIRC6 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | LTBP1 | GO:0035583 | sequestering of TGFbeta in extracellular matrix | 2022183|8617200 |
Tgene | LTBP1 | GO:1901388 | regulation of transforming growth factor beta activation | 2022183|8617200 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:33246273/chr2:32631567) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Amino Acid Sequences |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000421745 | BIRC6 | chr2 | 32756618 | + | ENST00000404816 | LTBP1 | chr2 | 33442618 | + | 16704 | 12425 | 134 | 15889 | 5251 |
ENST00000421745 | BIRC6 | chr2 | 32756618 | + | ENST00000354476 | LTBP1 | chr2 | 33442618 | + | 16854 | 12425 | 134 | 15892 | 5252 |
ENST00000421745 | BIRC6 | chr2 | 32756618 | + | ENST00000390003 | LTBP1 | chr2 | 33442618 | + | 16854 | 12425 | 134 | 15892 | 5252 |
ENST00000421745 | BIRC6 | chr2 | 32756618 | + | ENST00000418533 | LTBP1 | chr2 | 33442618 | + | 16725 | 12425 | 134 | 15763 | 5209 |
ENST00000421745 | BIRC6 | chr2 | 32756618 | + | ENST00000402934 | LTBP1 | chr2 | 33442618 | + | 16537 | 12425 | 134 | 15724 | 5196 |
ENST00000421745 | BIRC6 | chr2 | 32756618 | + | ENST00000404525 | LTBP1 | chr2 | 33442618 | + | 16695 | 12425 | 134 | 15730 | 5198 |
ENST00000421745 | BIRC6 | chr2 | 32756618 | + | ENST00000407925 | LTBP1 | chr2 | 33442618 | + | 16708 | 12425 | 134 | 15889 | 5251 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000421745 | ENST00000404816 | BIRC6 | chr2 | 32756618 | + | LTBP1 | chr2 | 33442618 | + | 0.00084513 | 0.9991549 |
ENST00000421745 | ENST00000354476 | BIRC6 | chr2 | 32756618 | + | LTBP1 | chr2 | 33442618 | + | 0.000887287 | 0.99911267 |
ENST00000421745 | ENST00000390003 | BIRC6 | chr2 | 32756618 | + | LTBP1 | chr2 | 33442618 | + | 0.000887287 | 0.99911267 |
ENST00000421745 | ENST00000418533 | BIRC6 | chr2 | 32756618 | + | LTBP1 | chr2 | 33442618 | + | 0.000524083 | 0.9994759 |
ENST00000421745 | ENST00000402934 | BIRC6 | chr2 | 32756618 | + | LTBP1 | chr2 | 33442618 | + | 0.000597064 | 0.9994029 |
ENST00000421745 | ENST00000404525 | BIRC6 | chr2 | 32756618 | + | LTBP1 | chr2 | 33442618 | + | 0.000715275 | 0.9992848 |
ENST00000421745 | ENST00000407925 | BIRC6 | chr2 | 32756618 | + | LTBP1 | chr2 | 33442618 | + | 0.000838952 | 0.999161 |
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Get the fusion protein sequences from here. |
Fusion protein sequence information is available in the fasta format. >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP |
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Fusion Protein Breakpoint Sequences for BIRC6-LTBP1 |
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Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Length(fusion protein) | BP in fusion protein | Peptide |
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Potential FusionNeoAntigen Information of BIRC6-LTBP1 in HLA I |
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![]() * We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5) |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA I | FusionNeoAntigen peptide | Binding score | Immunogenic score | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
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Potential FusionNeoAntigen Information of BIRC6-LTBP1 in HLA II |
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![]() * We used NetMHCIIpan v4.1 (%rank<0.5). |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA II | FusionNeoAntigen peptide | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
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Fusion breakpoint peptide structures of BIRC6-LTBP1 |
![]() * The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA. |
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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of BIRC6-LTBP1 |
![]() * We used Glide to predict the interaction between HLAs and neoantigens. |
HLA allele | PDB ID | File name | BPseq | Docking score | Glide score |
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Vaccine Design for the FusionNeoAntigens of BIRC6-LTBP1 |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide sequence | FusionNeoAntigen RNA sequence |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide | FusionNEoAntigen RNA sequence |
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Information of the samples that have these potential fusion neoantigens of BIRC6-LTBP1 |
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Cancer type | Fusion gene | Hchr | Hbp | Henst | Tchr | Tbp | Tenst | Sample |
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Potential target of CAR-T therapy development for BIRC6-LTBP1 |
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![]() * Minus value of BPloci means that the break point is located before the CDS. |
- In-frame and retained 'Transmembrane'. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
![]() * We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image. |
Hgene | Hchr | Hbp | Henst | Tgene | Tchr | Tbp | Tenst | DeepLoc result |
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Related Drugs to BIRC6-LTBP1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to BIRC6-LTBP1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |