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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:UVRAG-KCTD14

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: UVRAG-KCTD14
FusionPDB ID: 97794
FusionGDB2.0 ID: 97794
HgeneTgene
Gene symbol

UVRAG

KCTD14

Gene ID

7405

65987

Gene nameUV radiation resistance associatedpotassium channel tetramerization domain containing 14
SynonymsDHTX|VPS38|p63-
Cytomap

11q13.5

11q14.1

Type of geneprotein-codingprotein-coding
DescriptionUV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxyBTB/POZ domain-containing protein KCTD14potassium channel tetramerisation domain containing 14
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000356136, ENST00000528420, 
ENST00000531818, ENST00000532130, 
ENST00000533454, ENST00000539288, 
ENST00000525872, ENST00000538870, 
ENST00000533144, ENST00000353172, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score41 X 18 X 15=110704 X 2 X 2=16
# samples 495
** MAII scorelog2(49/11070*10)=-4.49772966266634
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/16*10)=1.64385618977472
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Fusion gene context

PubMed: UVRAG [Title/Abstract] AND KCTD14 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: UVRAG [Title/Abstract] AND KCTD14 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)UVRAG(75776832)-KCTD14(77728316), # samples:2
Anticipated loss of major functional domain due to fusion event.UVRAG-KCTD14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
UVRAG-KCTD14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
UVRAG-KCTD14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
UVRAG-KCTD14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
UVRAG-KCTD14 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
UVRAG-KCTD14 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
UVRAG-KCTD14 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUVRAG

GO:0071900

regulation of protein serine/threonine kinase activity

22542840

HgeneUVRAG

GO:0097352

autophagosome maturation

28306502

HgeneUVRAG

GO:0097680

double-strand break repair via classical nonhomologous end joining

22542840



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:75776832/chr11:77728316)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across UVRAG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KCTD14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000356136UVRAGchr1175776832+ENST00000353172KCTD14chr1177728316-310215461632223686
ENST00000528420UVRAGchr1175776832+ENST00000353172KCTD14chr1177728316-28431287961964622
ENST00000533454UVRAGchr1175776832+ENST00000353172KCTD14chr1177728316-24979416801618312
ENST00000531818UVRAGchr1175776832+ENST00000353172KCTD14chr1177728316-267511194471796449
ENST00000532130UVRAGchr1175776832+ENST00000353172KCTD14chr1177728316-2222666481343431
ENST00000539288UVRAGchr1175776832+ENST00000353172KCTD14chr1177728316-22897334721410312

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356136ENST00000353172UVRAGchr1175776832+KCTD14chr1177728316-0.0024449830.9975551
ENST00000528420ENST00000353172UVRAGchr1175776832+KCTD14chr1177728316-0.0020337210.9979663
ENST00000533454ENST00000353172UVRAGchr1175776832+KCTD14chr1177728316-0.0009051990.99909484
ENST00000531818ENST00000353172UVRAGchr1175776832+KCTD14chr1177728316-0.0017375710.99826247
ENST00000532130ENST00000353172UVRAGchr1175776832+KCTD14chr1177728316-0.0008545850.9991454
ENST00000539288ENST00000353172UVRAGchr1175776832+KCTD14chr1177728316-0.0007979320.9992021

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for UVRAG-KCTD14

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
UVRAGchr1175776832KCTD14chr11777283161119223FDYGVYLLNKNIAQMSTVVELNVGGE
UVRAGchr1175776832KCTD14chr11777283161287396FDYGVYLLNKNIAQMSTVVELNVGGE
UVRAGchr1175776832KCTD14chr11777283161546460FDYGVYLLNKNIAQMSTVVELNVGGE
UVRAGchr1175776832KCTD14chr1177728316666205FDYGVYLLNKNIAQMSTVVELNVGGE
UVRAGchr1175776832KCTD14chr117772831673386FDYGVYLLNKNIAQMSTVVELNVGGE
UVRAGchr1175776832KCTD14chr117772831694186FDYGVYLLNKNIAQMSTVVELNVGGE

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Potential FusionNeoAntigen Information of UVRAG-KCTD14 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
UVRAG-KCTD14_75776832_77728316.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:01AQMSTVVEL0.99840.87681221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B48:01AQMSTVVEL0.99820.76091221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B27:07AQMSTVVEL0.99710.51071221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B39:24AQMSTVVEL0.99530.52721221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B39:06AQMSTVVEL0.99390.76941221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:22AQMSTVVEL0.99090.5451221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:21AQMSTVVEL0.98760.66961221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:22LLNKNIAQM0.9870.6429615
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:67AQMSTVVEL0.98520.52091221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:24AQMSTVVEL0.98520.52091221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:30AQMSTVVEL0.98520.52091221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:11AQMSTVVEL0.98280.55951221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:04AQMSTVVEL0.97860.63271221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B40:01AQMSTVVEL0.97750.55791221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B39:01AQMSTVVEL0.97650.92071221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:11LLNKNIAQM0.97580.5602615
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:30LLNKNIAQM0.97510.5076615
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:67LLNKNIAQM0.97510.5076615
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:24LLNKNIAQM0.97510.5076615
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:17AQMSTVVEL0.97220.54391221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:38AQMSTVVEL0.96960.78481221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:04LLNKNIAQM0.9660.6746615
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:13LLNKNIAQM0.95960.5751615
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:27LLNKNIAQM0.95770.5805615
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:13AQMSTVVEL0.95690.75761221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:27AQMSTVVEL0.95640.63031221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:25AQMSTVVEL0.95250.95351221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:18AQMSTVVEL0.94720.84661221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B13:02AQMSTVVEL0.94430.76261221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B14:01AQMSTVVEL0.9440.84591221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B14:02AQMSTVVEL0.9440.84591221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:03AQMSTVVEL0.94080.87941221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B39:13AQMSTVVEL0.92360.92741221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B13:01AQMSTVVEL0.89680.97861221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:29AQMSTVVEL0.89010.52341221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:29LLNKNIAQM0.87950.5149615
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B38:02AQMSTVVEL0.87240.96711221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:10AQMSTVVEL0.86610.66611221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B50:01AQMSTVVEL0.8630.79571221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B38:01AQMSTVVEL0.8460.95821221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:20AQMSTVVEL0.84370.52861221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:35AQMSTVVEL0.82030.53441221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A32:13AQMSTVVEL0.70960.87121221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:37AQMSTVVEL0.66620.60991221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B52:01AQMSTVVEL0.1740.97351221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:04YLLNKNIAQM0.97890.5264515
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B48:01IAQMSTVVEL0.88150.56751121
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:21AQMSTVVELNV0.98970.6391223
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B13:02AQMSTVVELNV0.8660.81261223
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C12:12AQMSTVVEL0.99760.93711221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C12:04AQMSTVVEL0.99730.98081221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C06:03AQMSTVVEL0.99730.98511221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C04:14AQMSTVVEL0.99440.95851221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C04:06AQMSTVVEL0.99420.91721221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C15:06AQMSTVVEL0.99310.93811221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:04AQMSTVVEL0.99080.91591221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:07AQMSTVVEL0.99020.7721221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C03:07AQMSTVVEL0.98960.97471221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C08:04AQMSTVVEL0.98830.95221221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C08:13AQMSTVVEL0.98830.95221221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:07AQMSTVVEL0.98540.57891221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:01AQMSTVVEL0.98520.52091221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C03:19AQMSTVVEL0.98470.98781221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C08:03AQMSTVVEL0.98190.97981221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B48:03AQMSTVVEL0.98170.62081221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C07:13AQMSTVVEL0.98140.9431221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B39:12AQMSTVVEL0.97690.92471221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B39:09AQMSTVVEL0.97670.69351221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C07:29AQMSTVVEL0.97540.94371221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:01LLNKNIAQM0.97510.5076615
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C07:05AQMSTVVEL0.97380.97561221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C03:14AQMSTVVEL0.97090.97551221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:04LLNKNIAQM0.96960.8128615
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C07:46AQMSTVVEL0.96850.93931221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B39:08AQMSTVVEL0.96620.91841221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C07:19AQMSTVVEL0.96470.83071221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C07:10AQMSTVVEL0.96110.97251221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C07:27AQMSTVVEL0.96040.95971221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C07:80AQMSTVVEL0.95730.96081221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C07:67AQMSTVVEL0.95730.96081221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C02:06AQMSTVVEL0.95190.94461221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C12:16AQMSTVVEL0.9490.95771221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C07:95AQMSTVVEL0.93560.80621221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B39:05AQMSTVVEL0.87720.91461221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B44:10AQMSTVVEL0.80480.76161221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:05AQMSTVVEL0.72250.93141221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B14:03AQMSTVVEL0.62870.8561221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C15:02KNIAQMSTV0.99960.9357918
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:27AQMSTVVEL0.99860.87481221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:135AQMSTVVEL0.99860.87461221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:33AQMSTVVEL0.99840.87681221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:125AQMSTVVEL0.99840.87681221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:34AQMSTVVEL0.99840.87681221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:50AQMSTVVEL0.99770.88871221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:24AQMSTVVEL0.99770.88651221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B27:06AQMSTVVEL0.99720.70781221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B27:09AQMSTVVEL0.99530.64521221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C06:17AQMSTVVEL0.99410.98091221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C06:02AQMSTVVEL0.99410.98091221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C15:05AQMSTVVEL0.99270.90861221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:53AQMSTVVEL0.99250.84621221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C15:02AQMSTVVEL0.99240.91591221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:73AQMSTVVEL0.9920.90061221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C04:04AQMSTVVEL0.99080.92411221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C17:01AQMSTVVEL0.99060.93031221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C12:02AQMSTVVEL0.98820.96181221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:14AQMSTVVEL0.98770.56841221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:06AQMSTVVEL0.98760.66961221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C03:06AQMSTVVEL0.9870.98781221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B39:02AQMSTVVEL0.98620.92741221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:03AQMSTVVEL0.98420.67081221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C03:03AQMSTVVEL0.98390.98681221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C03:04AQMSTVVEL0.98390.98681221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:03LLNKNIAQM0.98360.6999615
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:35AQMSTVVEL0.98350.86421221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C08:01AQMSTVVEL0.98190.97981221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B40:12AQMSTVVEL0.98170.62081221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B39:31AQMSTVVEL0.97760.92051221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:54AQMSTVVEL0.97730.84251221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:68AQMSTVVEL0.97590.73741221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B40:36AQMSTVVEL0.97580.54251221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:12AQMSTVVEL0.97520.86061221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:30AQMSTVVEL0.9740.90011221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C07:04AQMSTVVEL0.97350.94991221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C03:05AQMSTVVEL0.97330.92321221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C06:08AQMSTVVEL0.97110.97111221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C03:67AQMSTVVEL0.97020.98121221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B40:49AQMSTVVEL0.96950.57911221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C02:10AQMSTVVEL0.96520.96011221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C02:02AQMSTVVEL0.96520.96011221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A32:01AQMSTVVEL0.96060.89641221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C06:06AQMSTVVEL0.96030.98551221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C18:01AQMSTVVEL0.95810.92311221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C07:02AQMSTVVEL0.95730.96081221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:39AQMSTVVEL0.9550.90321221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:39LLNKNIAQM0.95360.7076615
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C07:01AQMSTVVEL0.94860.78451221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C07:17AQMSTVVEL0.94010.96491221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-C07:22AQMSTVVEL0.93560.79041221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B40:21AQMSTVVEL0.93290.6931221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B39:11AQMSTVVEL0.92280.91281221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:73LLNKNIAQM0.91890.7025615
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B50:04AQMSTVVEL0.8630.79571221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B50:05AQMSTVVEL0.8630.79571221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B38:05AQMSTVVEL0.8460.95821221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B48:02AQMSTVVEL0.83980.96391221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B35:13AQMSTVVEL0.8150.93431221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:30LLNKNIAQM0.80630.7504615
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B35:20AQMSTVVEL0.72570.97431221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:09AQMSTVVEL0.72480.84551221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:20AQMSTVVEL0.71730.96141221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B35:28AQMSTVVEL0.71660.97061221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B07:13AQMSTVVEL0.49550.74451221
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:73IAQMSTVVEL0.98460.83811121
UVRAG-KCTD14chr1175776832chr11777283161546HLA-B15:30IAQMSTVVEL0.97890.76191121
UVRAG-KCTD14chr1175776832chr11777283161546HLA-A02:06AQMSTVVELNV0.98970.6391223

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Potential FusionNeoAntigen Information of UVRAG-KCTD14 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
UVRAG-KCTD14_75776832_77728316.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0403LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0403NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0405LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0405NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0411LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0411NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0411LLNKNIAQMSTVVEL621
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0424LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0424NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0427NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0427LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0429LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0429NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0430LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0430NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0434YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0434DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0439LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0439NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0440NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0440LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0441LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0441NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0442NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0442LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0445LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0445NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0446LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0446NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0448LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0448NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0449LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0449NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0450LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0450NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0451LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0451NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0452LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0452NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0453NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0453LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0456NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0456LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0457LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0457NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0459LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0459NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0460LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0460NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0465NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0465LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0466DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0466YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0467LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0467NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0468NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0468LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0471LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0471NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0472YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0474YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0474DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0477LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0477NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0479NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0479LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0480LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0480NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0483LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0483NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0484LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0484NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0485LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0485NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0487LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0487NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0488NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0488LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0489LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0489NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0491LNKNIAQMSTVVELN722
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0491NKNIAQMSTVVELNV823
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0491LLNKNIAQMSTVVEL621
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0804DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0804FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0815DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0820DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0820FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0824DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0828DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0828FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0830DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0831DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-0831FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1104DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1104FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1105DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1106DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1106FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1113DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1118DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1118FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1119DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1125DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1130YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1130DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1131DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1134DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1134FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1135DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1135FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1138DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1138FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1142DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1142FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1143DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1143FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1144DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1144FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1145DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1146DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1146FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1147DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1147FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1150DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1150FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1156DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1156FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1157DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1157FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1158DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1158FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1160DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1160FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1167DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1167FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1177DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1177FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1178DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1178FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1182DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1183DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1183FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1184DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1184FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1188DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1188FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1192DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1204DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1209DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1306DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1306FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1311DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1311FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1318DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1342DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1342FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1344DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1344FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1360DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1367YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1367DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1382DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1385DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1385YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1386DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1402DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1402YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1403DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1406DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1406FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1409DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1412DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1415DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1415FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1417DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1417FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1419DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1419YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1420DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1420FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1424DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1424YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1429DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1429FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1430DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1434DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1434FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1437DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1440DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1441DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1441YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1446YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1446DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1447YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1447DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1451DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1452DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1452FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1467DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1477DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1480DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1480FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1481DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1483DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1483FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1484DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1484FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1489DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1489YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1494DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1494YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1498DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB1-1498YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0202YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0202DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0202GVYLLNKNIAQMSTV318
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0202FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0205YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0205DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0205GVYLLNKNIAQMSTV318
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0205FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0210YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0210DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0210GVYLLNKNIAQMSTV318
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0210FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0211YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0211DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0211GVYLLNKNIAQMSTV318
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0211FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0212YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0212DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0212GVYLLNKNIAQMSTV318
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0212FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0213YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0213DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0213GVYLLNKNIAQMSTV318
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0213FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0214YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0215YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0215DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0215GVYLLNKNIAQMSTV318
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0215FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0217YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0217DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0217GVYLLNKNIAQMSTV318
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0217FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0218YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0218DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0218GVYLLNKNIAQMSTV318
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0218FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0219YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0219DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0219GVYLLNKNIAQMSTV318
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0220YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0220DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0220GVYLLNKNIAQMSTV318
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0220FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0222YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0222DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0222GVYLLNKNIAQMSTV318
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0223YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0223DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0223GVYLLNKNIAQMSTV318
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0223FDYGVYLLNKNIAQM015
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0225YGVYLLNKNIAQMST217
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0225DYGVYLLNKNIAQMS116
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0225GVYLLNKNIAQMSTV318
UVRAG-KCTD14chr1175776832chr11777283161546DRB3-0225FDYGVYLLNKNIAQM015

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Fusion breakpoint peptide structures of UVRAG-KCTD14

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
5248LLNKNIAQMSTVVEUVRAGKCTD14chr1175776832chr11777283161546

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of UVRAG-KCTD14

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN5248LLNKNIAQMSTVVE-7.9962-8.1096
HLA-B14:023BVN5248LLNKNIAQMSTVVE-5.70842-6.74372
HLA-B52:013W395248LLNKNIAQMSTVVE-6.83737-6.95077
HLA-B52:013W395248LLNKNIAQMSTVVE-4.4836-5.5189
HLA-A11:014UQ25248LLNKNIAQMSTVVE-10.0067-10.1201
HLA-A11:014UQ25248LLNKNIAQMSTVVE-9.03915-10.0745
HLA-A24:025HGA5248LLNKNIAQMSTVVE-6.56204-6.67544
HLA-A24:025HGA5248LLNKNIAQMSTVVE-5.42271-6.45801
HLA-B44:053DX85248LLNKNIAQMSTVVE-7.85648-8.89178
HLA-B44:053DX85248LLNKNIAQMSTVVE-5.3978-5.5112
HLA-A02:016TDR5248LLNKNIAQMSTVVE-3.37154-4.40684

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Vaccine Design for the FusionNeoAntigens of UVRAG-KCTD14

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
UVRAG-KCTD14chr1175776832chr11777283161121IAQMSTVVELGCACAGATGTCTACTGTTGTGGAGCTGAAC
UVRAG-KCTD14chr1175776832chr11777283161221AQMSTVVELCAGATGTCTACTGTTGTGGAGCTGAAC
UVRAG-KCTD14chr1175776832chr11777283161223AQMSTVVELNVCAGATGTCTACTGTTGTGGAGCTGAACGTCGGG
UVRAG-KCTD14chr1175776832chr1177728316515YLLNKNIAQMCTTCTGAACAAAAATATAGCACAGATGTCT
UVRAG-KCTD14chr1175776832chr1177728316615LLNKNIAQMCTGAACAAAAATATAGCACAGATGTCT
UVRAG-KCTD14chr1175776832chr1177728316918KNIAQMSTVAATATAGCACAGATGTCTACTGTTGTG

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
UVRAG-KCTD14chr1175776832chr1177728316015FDYGVYLLNKNIAQMGATTATGGTGTCTATCTTCTGAACAAAAATATAGCACAGATGTCT
UVRAG-KCTD14chr1175776832chr1177728316116DYGVYLLNKNIAQMSTATGGTGTCTATCTTCTGAACAAAAATATAGCACAGATGTCTACT
UVRAG-KCTD14chr1175776832chr1177728316217YGVYLLNKNIAQMSTGGTGTCTATCTTCTGAACAAAAATATAGCACAGATGTCTACTGTT
UVRAG-KCTD14chr1175776832chr1177728316318GVYLLNKNIAQMSTVGTCTATCTTCTGAACAAAAATATAGCACAGATGTCTACTGTTGTG
UVRAG-KCTD14chr1175776832chr1177728316621LLNKNIAQMSTVVELCTGAACAAAAATATAGCACAGATGTCTACTGTTGTGGAGCTGAAC
UVRAG-KCTD14chr1175776832chr1177728316722LNKNIAQMSTVVELNAACAAAAATATAGCACAGATGTCTACTGTTGTGGAGCTGAACGTC
UVRAG-KCTD14chr1175776832chr1177728316823NKNIAQMSTVVELNVAAAAATATAGCACAGATGTCTACTGTTGTGGAGCTGAACGTCGGG

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Information of the samples that have these potential fusion neoantigens of UVRAG-KCTD14

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
BRCAUVRAG-KCTD14chr1175776832ENST00000356136chr1177728316ENST00000353172TCGA-BH-A0BD-01A

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Potential target of CAR-T therapy development for UVRAG-KCTD14

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to UVRAG-KCTD14

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to UVRAG-KCTD14

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource